<SEC-DOCUMENT>0000886163-19-000041.txt : 20190228
<SEC-HEADER>0000886163-19-000041.hdr.sgml : 20190228
<ACCEPTANCE-DATETIME>20190228162401
ACCESSION NUMBER:		0000886163-19-000041
CONFORMED SUBMISSION TYPE:	10-K
PUBLIC DOCUMENT COUNT:		84
CONFORMED PERIOD OF REPORT:	20181231
FILED AS OF DATE:		20190228
DATE AS OF CHANGE:		20190228

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			LIGAND PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000886163
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				770160744
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		10-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33093
		FILM NUMBER:		19643635

	BUSINESS ADDRESS:	
		STREET 1:		3911 SORRENTO VALLEY BLVD
		STREET 2:		SUITE 110
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		858-550-7500

	MAIL ADDRESS:	
		STREET 1:		3911 SORRENTO VALLEY BLVD
		STREET 2:		SUITE 110
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
</SEC-HEADER>
<DOCUMENT>
<TYPE>10-K
<SEQUENCE>1
<FILENAME>lgnd-20181231.htm
<DESCRIPTION>10-K
<TEXT>
<XBRL>
<?xml version="1.0" ?><!--XBRL Document Created with Wdesk from Workiva--><!--Copyright 2017 Workiva--><!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913--><html xmlns="http://www.w3.org/1999/xhtml" xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31" xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns:srt="http://fasb.org/srt/2018-01-31" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:lgnd="http://www.ligand.com/20181231" xmlns:iso4217="http://www.xbrl.org/2003/iso4217" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2015-02-26" xmlns:us-gaap="http://fasb.org/us-gaap/2018-01-31" xmlns:xbrldi="http://xbrl.org/2006/xbrldi" xmlns:country="http://xbrl.sec.gov/country/2017-01-31" xmlns:dei="http://xbrl.sec.gov/dei/2018-01-31" xmlns:xlink="http://www.w3.org/1999/xlink"><head><meta http-equiv="Content-Type" content="text/html"></meta>


<title>Document</title></head><body><div style="display:none"><ix:header><ix:hidden><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityRegistrantName" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMS0xLTEtMS0w_664372ef-abc9-41e2-991e-306c3507328b">LIGAND PHARMACEUTICALS INC</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt:datemonthdayyear" name="dei:DocumentPeriodEndDate" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNC0xLTEtMS0w_51835910-f64d-42db-a45c-3525c786aabb">12/31/2018</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt:booleanfalse" name="dei:AmendmentFlag" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNS0xLTEtMS0w_daac6f94-5b9a-4997-8168-370f63f613d4">FALSE</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:DocumentFiscalYearFocus" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNi0xLTEtMS0w_a80f2307-60be-4ffd-b2e4-63c2a823b10a">2018</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:DocumentFiscalPeriodFocus" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNy0xLTEtMS0w_61e44828-3c70-4c41-922e-ceccdbf68858">FY</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityFilerCategory" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfOS0xLTEtMS0w_1e6642e5-0764-4b98-b2d4-1694ae72d00e" escape="true">Large Accelerated Filer</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt:booleanfalse" name="dei:EntityEmergingGrowthCompany" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTAtMS0xLTEtMA_5f64c1cb-760b-4ced-9508-eefea73811db">FALSE</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt:booleanfalse" name="dei:EntitySmallBusiness" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTEtMS0xLTEtMA_eab3232e-9ea5-4f3a-917d-1fdf74c983b3">FALSE</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt:booleanfalse" name="dei:EntityShellCompany" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTItMS0xLTEtNTkzMQ_eac89285-89f5-46d1-94d8-0255b82d2567">FALSE</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityVoluntaryFilers" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTQtMS0xLTEtMA_f722c10e-b5cc-45db-b27e-eba9ffcb3e58">No</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityWellKnownSeasonedIssuer" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTUtMS0xLTEtMA_c260cb14-f0ce-4c6e-ae00-cfe039442931">Yes</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityCurrentReportingStatus" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTYtMS0xLTEtMA_76d1e59d-e071-426f-8220-26e2be511690">Yes</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:EntityCentralIndexKey" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RleHRyZWdpb246OGEwM2QzNjAxOTczNGFhYmIzNWQwYmRhYzk5NzNhOTlfMTMxOTQxMzk1MzM0MDI_f6e2abca-af7d-4d80-bc26-b8695f60c6ce">0000886163</ix:nonNumeric><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:CurrentFiscalYearEndDate" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RleHRyZWdpb246OGEwM2QzNjAxOTczNGFhYmIzNWQwYmRhYzk5NzNhOTlfMTMxOTQxMzk1MzM0MDM_cdf962e9-90c8-42ae-921f-b5b9ca8b9251">--12-31</ix:nonNumeric><ix:nonFraction unitRef="usdPerShare" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" name="us-gaap:CommonStockParOrStatedValuePerShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzItMS0xLTEtMA_7ecb702b-833a-4bc7-9532-2f4b344e3156">0.001</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="INF" name="us-gaap:CommonStockParOrStatedValuePerShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzItMy0xLTEtMA_cae165b3-d3f9-4335-9bed-7484d05caf24">0.001</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesAuthorized" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzMtMS0xLTEtMA_bd9bedfa-bcbe-493e-a07b-ed679a5aee4b">60,000,000</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesAuthorized" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzMtMy0xLTEtMA_13042ee9-ff33-4470-b54e-084866506589">33,333,333</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesIssued" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzQtMS0xLTEtMA_7f02baec-28b7-4927-a6d6-abcac52c706e">20,765,533</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesIssued" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzQtMy0xLTEtMA_2673b5df-ce33-45c6-88da-3d5b5258750c">21,148,665</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzUtMS0xLTEtMA_1a885dff-7d6a-40f8-9e68-34a52d3414c0">20,765,533</ix:nonFraction><ix:nonFraction unitRef="shares" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:CommonStockSharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzUtMy0xLTEtMA_7d3173a5-cbb3-454e-8131-f94f57caf302">21,148,665</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" format="ixt:zerodash" name="us-gaap:InventoryWriteDown" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTo1NDQwMWExOWJiNTE0MjUzOGYzNTY0NzM1OTFlNWQ4Yi90YWJsZXJhbmdlOjU0NDAxYTE5YmI1MTQyNTM4ZjM1NjQ3MzU5MWU1ZDhiXzEtMy0xLTEtMA_c4025e9d-b14e-42c6-b228-0bc2425d6627">&#8212;</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231" decimals="4" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpmOTI1ZTQ3NWQyODc0YTgzOTdjMzZlZDI0YmNlMmEzMy90YWJsZXJhbmdlOmY5MjVlNDc1ZDI4NzRhODM5N2MzNmVkMjRiY2UyYTMzXzEtMS0xLTEtMA_85aefc79-c26a-4e68-8286-9816c3eb4260">12.50</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231" decimals="4" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpmOTI1ZTQ3NWQyODc0YTgzOTdjMzZlZDI0YmNlMmEzMy90YWJsZXJhbmdlOmY5MjVlNDc1ZDI4NzRhODM5N2MzNmVkMjRiY2UyYTMzXzItMS0xLTEtMA_b07a7536-f8cd-4c6f-8126-57b140ba95e9">2.08</ix:nonFraction><ix:nonNumeric contextRef="i2ba96270f73845a489eec892606f151e_D20180101-20181231" format="ixt-sec:durwordsen" name="lgnd:ThresholdBusinessDaysforRepaymentofPrincipal" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5NA_96a7094d-2abf-46bb-8478-1d9d9dc4f0f5">three days</ix:nonNumeric><ix:nonFraction unitRef="trading_day" contextRef="i2ba96270f73845a489eec892606f151e_D20180101-20181231" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5NQ_8697301c-ec04-48fc-b7e3-21d65ad9278a">50</ix:nonFraction><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt-sec:durwordsen" name="lgnd:MaturityPeriodOfHighlyLiquidSecuritiesMaximum" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5Ng_29ab42d8-1579-4e92-a54e-4606d62246ea">three months</ix:nonNumeric><ix:nonNumeric contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:PropertyPlantAndEquipmentUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5Nw_617acb72-a5b3-420b-a338-e89ea52c5adf">three years</ix:nonNumeric><ix:nonNumeric contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:PropertyPlantAndEquipmentUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5OA_5c37b17a-8f28-4afb-8fe2-a519e0efdd0b">ten years</ix:nonNumeric><ix:nonNumeric contextRef="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5OQ_ba2308d5-a410-47a8-8243-66ff1e3dddf5">six months</ix:nonNumeric><ix:nonNumeric contextRef="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzcwMA_fed73d4b-9cb6-418d-a1f0-f37e607d4d27">forty-two months</ix:nonNumeric><ix:nonFraction unitRef="number" contextRef="i0aadecee51e54de98ac550079bea27c4_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMS0xLTEtNzkwMA_324e00e1-3ace-43b7-a0c4-01f16d0b05b2">0.3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i064e8a313dcd4597a31a3e322d0fb198_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMi0xLTEtNzkwMg_e9e84686-113d-47dd-a455-c67005ae89c6">0.35</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ia1016c7a3fb3456dadccac23f7e35a59_I20180619" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMy0xLTEtNzkwNA_03605559-c4d1-4028-b078-37a9f108e38e">0.3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i5be21f383f784dc5bdb8f26fd11bd5f8_I20180619" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtNC0xLTEtNzkwNg_48784cf2-0547-46aa-bddf-8dacb2ab478e">0.35</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="id3f44e4150824aac8cb8233b4f6c5332_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMS0xLTEtNzkxMw_5cb6e46b-da75-4e05-85ac-f6177929b87d">0.3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i4a4309c3a4644756b0b0e2a41966e07d_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMi0xLTEtNzkxMQ_b7ed2a1c-f724-4e35-8b42-9a4a08838b13">0.35</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i019545928c8d42fa914265e7cce06db4_I20181231" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMy0xLTEtNzkxMA_fe6ce941-f8ca-47a2-9ec6-ac0b828b676f">0.3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i421c6d753d8042d6ba4f5dea715b2015_I20181231" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctNC0xLTEtNzkwOA_3dcca4cb-bba4-4b79-ba7d-3ce2efb5e0f9">0.35</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i3574527256f745d8bcdc0cb4541c738e_I20180101" decimals="-5" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzE2NDkyNjc0NDI2NTU_59a57916-c03e-4868-b531-a2b54eba9479">2700000</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231" decimals="-5" name="us-gaap:NetCashProvidedByUsedInOperatingActivities" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzE2NDkyNjc0NDI4NTg_992cabfc-4a13-4a7c-8abb-2eb6fbd0d96a">5000000</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleConversionRatio1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NDQvZnJhZzowYzE0NDJmZWNkZmU0MWM5OWZkNjUxYjA4M2RjZGE2Zi90YWJsZTpiZmJmMDIwZDFjNTE0YmVjYmFjOWExYzQ5ODdhZTkyMy90YWJsZXJhbmdlOmJmYmYwMjBkMWM1MTRiZWNiYWM5YTFjNDk4N2FlOTIzXzItMS0xLTEtMA_5aaea6fc-5d62-4657-b242-643cbcfe79f7">0.0133251</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i2fb1a05c9a404a7a9804793a41837e00_D20180501-20180531" decimals="INF" name="us-gaap:DebtInstrumentConvertibleConversionRatio1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NDQvZnJhZzowYzE0NDJmZWNkZmU0MWM5OWZkNjUxYjA4M2RjZGE2Zi90YWJsZTpiZmJmMDIwZDFjNTE0YmVjYmFjOWExYzQ5ODdhZTkyMy90YWJsZXJhbmdlOmJmYmYwMjBkMWM1MTRiZWNiYWM5YTFjNDk4N2FlOTIzXzItMi0xLTEtOTA3MA_083b8786-38a3-416d-8c3e-14d2dc6a559a">0.0040244</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" name="us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzItMS0xLTEtMA_ccc465b3-fe26-48ba-8742-5936629c6f83">12.8</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" name="us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzMtMS0xLTEtMA_89127199-1222-4456-9ee3-abb88d3ec68c">12.8</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" name="us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzQtMS0xLTEtMA_6a6750cd-49dd-47e5-accf-66d4bc325b00">12.8</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzUtMS0xLTEtOTAxNw_d8a39809-3da4-4ff8-83b4-cd81537f0aab">12.8</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" format="ixt:zerodash" name="us-gaap:ImpairmentOfIntangibleAssetsFinitelived" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzgtMS0xLTEtMA_62e0d75b-c661-4caf-b6c5-cf32a6e82d06">&#8212;</ix:nonFraction><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="INF" format="ixt:zerodash" name="us-gaap:ImpairmentOfIntangibleAssetsFinitelived" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzgtMi0xLTEtMA_1df3d65b-ba4c-473a-9538-7b2f8df72cdf">&#8212;</ix:nonFraction><ix:nonNumeric contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:PropertyPlantAndEquipmentUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90ZXh0cmVnaW9uOjMwZGE0MmZmNmQ0NTQ5MmNhNDk4OWVjMTQzZDAxNmZkXzE2Ng_85c08209-0071-4b50-bfac-6e8bb1f6f9ab">three years</ix:nonNumeric><ix:nonNumeric contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:PropertyPlantAndEquipmentUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90ZXh0cmVnaW9uOjMwZGE0MmZmNmQ0NTQ5MmNhNDk4OWVjMTQzZDAxNmZkXzE2Nw_764dca8e-a408-4556-80a9-18fa16b12ce0">ten years</ix:nonNumeric><ix:nonFraction unitRef="number" contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMS0xLTEtMA_52090cec-3cd7-4ab0-a036-66bb95f80a09">2.7</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMi0xLTEtMA_54253374-6ab6-4ab9-946e-c4d830f075ef">2</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMy0xLTEtMA_4a774be2-0796-4315-8660-345c675050f3">1.3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMS0xLTEtMA_b3f7c563-9920-49ae-8fab-2dc384204213">3</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMi0xLTEtMA_c245a9a2-5fe6-4142-8f1e-c6b3b58684b3">2.2</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231" decimals="3" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMy0xLTEtMA_871a4a92-f131-4eac-b559-2a3768db9eaa">1.9</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMS0xLTEtMA_41b7a74c-fc92-4ffe-8a76-7b7da05fd0b6">33</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMi0xLTEtMA_d7b54d11-f42a-4868-bc92-b5c84c594612">43</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMy0xLTEtMA_41329bfa-d72f-41e5-8271-c7673520bc18">48</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMS0xLTEtMA_f5362512-9dc3-4936-aeeb-c06f322150a8">36</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMi0xLTEtMA_0b2eee2e-23e1-4c79-9b35-5690abc9027e">47</ix:nonFraction><ix:nonFraction unitRef="number" contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMy0xLTEtMA_1eeaf3eb-d012-4ab5-aec4-d3a9173ca48c">50</ix:nonFraction><ix:nonNumeric contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMS0xLTEtMA_2d4d82ad-e822-40ef-bd58-fdb05d4f5ce0">5.1</ix:nonNumeric><ix:nonNumeric contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMi0xLTEtMA_1e86d94f-ab3f-4f1f-8921-8bc0469e5850">6.5</ix:nonNumeric><ix:nonNumeric contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMy0xLTEtODk2NQ_64a8f7ae-9a52-40ca-a4ce-542f531f2087">6.6</ix:nonNumeric><ix:nonNumeric contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMS0xLTEtMA_9c4b0b1b-c687-4947-8e6c-2ace46b198c4">5.8</ix:nonNumeric><ix:nonNumeric contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMi0xLTEtMA_39a7e4df-e240-4045-a00d-bb925f913494">6.8</ix:nonNumeric><ix:nonNumeric contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMy0xLTEtODk2Nw_530e085b-b3d6-4136-bae4-906e8475d861">6.7</ix:nonNumeric><ix:nonFraction unitRef="usdPerShare" contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEtMi0xLTEtMA_0842c184-af4c-4ca0-8e46-16bc4652cced">8.58</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEtNC0xLTEtMA_ab41b3fe-997e-48ea-8928-491ac26b448e">10.05</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzItMi0xLTEtMA_f4c60c03-1629-4be2-bd37-f1b45a043d02">10.12</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzItNC0xLTEtMA_a3f13b85-a825-43b8-a674-055105878342">12.81</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzMtMi0xLTEtMA_cfb5092a-5bae-4fc1-9af7-0428ce891c85">14.47</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzMtNC0xLTEtMA_25eae8fd-a365-4978-9bea-b794040271af">14.47</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzQtMi0xLTEtMA_0ccda0f1-aea1-406b-9070-4c9dbc8c82ff">16.14</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzQtNC0xLTEtMA_98549fa1-7523-4bbc-a661-05d76d8c63ef">17.88</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzUtMi0xLTEtMA_8c2f0671-4151-4281-b001-ee434f102c7b">21.92</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzUtNC0xLTEtMA_24a5af42-52ef-42a0-abfa-d5428854bfd4">21.92</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzYtMi0xLTEtMA_63b8a1dc-7c40-4954-85ca-46b57069d72e">32.00</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzYtNC0xLTEtMA_9d9aa1d7-eb5f-448f-8887-0efb520d3fd4">56.26</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzctMi0xLTEtMA_3a8eade5-8ae5-4949-a252-d7f95a581686">63.58</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzctNC0xLTEtMA_5abc0b6a-ec2a-47f5-8825-6e7275932fea">67.53</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzgtMi0xLTEtMA_d6a4c37d-6e86-4fbb-92a8-38bdf6bcea88">74.42</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzgtNC0xLTEtMA_84f4f14c-2243-45ee-93cf-617172f4164d">74.42</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzktMi0xLTEtMA_779dee8b-437c-448c-af34-428865da0ddc">85.79</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzktNC0xLTEtMA_68fcc4ff-2b17-44bc-97ac-06521f18d7e7">100.38</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEwLTItMS0xLTA_cc761a62-43fa-4761-80bd-9b47f692aa51">101.15</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEwLTQtMS0xLTA_e9861da8-43ab-4d3f-a0dc-dbe9c65005d3">195.91</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzExLTItMS0xLTA_5cab3298-642b-45db-a1e7-d31f9b70ddd4">8.58</ix:nonFraction><ix:nonFraction unitRef="usdPerShare" contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231" decimals="INF" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzExLTQtMS0xLTA_e043ff86-d033-4158-b166-1ea8582ab7b6">195.91</ix:nonFraction><ix:nonNumeric contextRef="i8f913262edf243adae4d2f256243ef16_D20150901-20150930" format="ixt-sec:durwordsen" name="us-gaap:StockRepurchaseProgramPeriodInForce1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90ZXh0cmVnaW9uOmJkZjFkZjcwOWVkMjQ4YjBhNzIxOTZlMDVmZGUxODE5XzI4Ng_e219895e-5989-436f-8943-e2a9d49e7c09">three years</ix:nonNumeric></ix:hidden><ix:references><link:schemaRef xlink:type="simple" xlink:href="lgnd-20181231.xsd"></link:schemaRef></ix:references><ix:resources><xbrli:context id="id13a97144b904710b9835494780d5820_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="usd"><xbrli:measure>iso4217:USD</xbrli:measure></xbrli:unit><xbrli:context id="i57786fa40fdb47bdb16a704aefea1269_I20180630"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2018-06-30</xbrli:instant></xbrli:period></xbrli:context><xbrli:unit id="shares"><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unit><xbrli:context id="i7732d073cf4e48638e3a966a3396d67c_I20190225"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2019-02-25</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i87420e1b166545afb11eefa8eb1ab74c_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:unit id="usdPerShare"><xbrli:divide><xbrli:unitNumerator><xbrli:measure>iso4217:USD</xbrli:measure></xbrli:unitNumerator><xbrli:unitDenominator><xbrli:measure>xbrli:shares</xbrli:measure></xbrli:unitDenominator></xbrli:divide></xbrli:unit><xbrli:context id="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="id52ed0969c704d12ac017e1b160c1fed_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i47f87ffe68104f86a60d18b2b37e6cf3_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i827aa32e6966431f90040e4f23139fce_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if12b4d59cd2641ccb993432a96845435_I20151231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2015-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia9cbdd5a3f014dbfba8949b4362c8099_I20151231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2015-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ied16ee55eeae4367832c19a676fd4c62_I20151231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2015-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4649e39780384e179cb5b74b4192a407_I20151231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2015-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib4c3c6fac973483badc44a66252c9222_I20151231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2015-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1a2836d1fbd04b178ed87e38468a92c5_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i83e610145e1441a4a48edbf5a5efb62b_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i7da8d16c399b44818efd38241c41af9b_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1119817d95d04c2b84b6f21adc149bc8_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if8adb73be9d64177a10495f9d227b467_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i619dc5c14c054866a55684440355f164_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i188efce7ecde4338afd75e87443c6147_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i56fd83bc6dc042639ae1df971a9f4d20_I20170101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib96266c9cd9e42b68a5de54609fb51bd_I20170101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i33d2f89847cf48949592096f2d579f2b_I20170101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1f9437583206454497ad1119bfadd777_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ic608cbca1fef42b885a41d66ca7b19bd_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8b39fe8e03bc43f49fbf934d621cb24c_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i2513fadb593f42d3b8500a28dadd898f_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i16eca74f8d9c46a28663ad714fd5a4b5_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8d92baeda9ac47a986e2a5bd6eacdbf2_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i3574527256f745d8bcdc0cb4541c738e_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i86047298eb4f4ea5ba70e04cad22157a_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic7fb939626f5447db0b459d9b7bc82d1_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i933a7ea4fa9f4cc7bf26d93ee66f026b_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ie022521383864c29a350e9f710b3a989_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia9f65f9bd2374512bb8783927196d39a_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibcb5b487ee794160bf522b883cfa27c7_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id4a587395c674ab4bf495afb6bd1140b_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibf1a2a4d3d614da2a9e3262a761010bc_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i346f6d3d9c4c4913bcb746295c506010_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i4604c286cb3b4c23b3e7c54016351f4f_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i38e7892ad1fc44c687187391e73e15ad_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i401746069dc0428bae920f833bd24769_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i152983bb0da8462dbdf2be5c4ba3bc18_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="number"><xbrli:measure>xbrli:pure</xbrli:measure></xbrli:unit><xbrli:context id="ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i3029e46160e643808e723653c88b6bac_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i223dab5f73e347b9b79caa31f48b5d33_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iad54ce0fea834c76ad026f321579313c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i43cdf2b8a77549fda2334e555da01d30_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i966b40b605c54c23a7a845e4be0cfade_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1c82d6eeab5342c98f34c3b8321892fc_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2153cdb62e2e4f53a2c6274726b9b87a_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i151ec7ab8a8b4a41b242da4ab90bcbae_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if9a0fc3b1b494d80a80b515f64915b07_I20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-10-06</xbrli:instant></xbrli:period></xbrli:context><xbrli:unit id="right"><xbrli:measure>lgnd:right</xbrli:measure></xbrli:unit><xbrli:context id="i269cf529b8f542d6b6e89cfb73d21395_I20100131"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2010-01-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i06d7e832be914ea4927e544711c5f918_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoandCorMatrixMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1714ac5410ad49d586a22807a601a7c8_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoandCorMatrixMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1b15f9f5711d44a591a3a36a58b9681a_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if37a84377d584e49a64fd37c3dc17dfb_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i6a92d032fd254b68a22e68edb0bb484e_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:SelexisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iea65327226544655a478dc62c46f5a1e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:SelexisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id9810b34412c4c1692e219b8fa0e1127_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib3eda2c10c4048a7aa0bacbfdfdfbc14_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8d095d9391b44d2a86b19f26283e7dc2_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9de660fb7aac4b88a7f3df2f717fed6d_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i41125f6764344dc486a91d878d152ad5_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:TitleOfIndividualAxis">us-gaap:DirectorMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="dei:LegalEntityAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i4399b7aa92d94af1af9043d8910747e6_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i7fc73450defc41569175c47bffd04a31_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i35202cb30da54ce3b43396a39f8f50fd_I20160503"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-05-03</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9ba7c91a27af4a8b9cc9746e85a2d4d0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:CorMatrixMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i7549ea636c7549ba8a48714cecadea82_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:CorMatrixMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib11ae4f07611449daceda5854c74bb9c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if72b93facdb542d6b9aa3d2def1abd30_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic47989b86a534d43a5bfc32cf62712d3_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i60f3b04793a34fca8e8b2fc0fd8651db_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1c77c0695f9f4bc39202a1ee3b68fe5b_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i15a3fcbde8c3460cb635412e65ed0c9c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i9ae47d774632454eacbfe62e6c31f927_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8689e4eec8504099bab348e57f6a9828_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8a17769dfb7942a285a0d743e736cb10_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib8aea3ed0ca949ac8970d2f8fe87f5bf_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i57170c9749ff46cb9f3837ec92589b71_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia775da1fbd8a416c8effcacdb92628e3_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i18a21a167bc74581b1487f6c8625553e_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i719ef5c241d44dbd96e30c1fa3f49f12_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1d061d85ca7a40dba5a324fbc7d0020f_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i815a29c81959435e8d5fef20b9d28e7a_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i26c94f297be24d6a90b411c3a92ab896_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i07237780f1df476eab12d1e41646c600_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia7034272bd6c43f6b5e9790c96dd349d_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ifeacc0dfa0ef409c9bf44db88ebbe700_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i305991a6fef5462c822324d86c4372dd_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i1d2a7464c56c40d39f92de328c3dd17e_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2534882e69ce43a6b613a1d083bfb3bd_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i4f60f855c1a14d8ab2bd47c786fc554e_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ie60c64b8008d42408987815303a30765_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia6e4af4ff3e0471097da34093a9ca62b_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="icd3fbafcbe94483b8d0196d9163c3fdb_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i0313533c50f047899180474a41ba7930_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i39dc95b331cd4a8faf8361f5540b8486_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ic8aa5f1c584f420aa7237defcce7252f_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6a68a109b1a44264b74ff24de2d81961_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4a0ce876e13c454b96f993d4d4ad5af9_D20070101-20071231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2007-01-01</xbrli:startDate><xbrli:endDate>2007-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6b500c2fbd5346e2a6d6116c3b290d3c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8e9409e1ae334493b8b799a5136ed402_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:SeniorNotesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i970ccee7a80949d687b85a9d2bf7e349_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id59bcc52dcb84716a983b5657976b3d8_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-22</xbrli:startDate><xbrli:endDate>2018-05-22</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i07c0e2d53ab44177baafdb7c634d98df_D20180619-20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-06-19</xbrli:startDate><xbrli:endDate>2018-06-19</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ie0bd90f3b36c43ff967e6b073bb482f5_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie646486a057a4a24abd210fcf89ec5ac_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5528cc9246cd4cbf9e55a7081d960d09_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i36c8e54238ca4f048bcdea0102a51a07_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie6b95d8edafe43388cdc0a5d870ca950_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="icf8c60c7fdb64e0ba05e9b87d3d24fd7_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i68d6900fd0a8486397608f93ae2f2950_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1ab3629dd4a84f25af6a6ed28fff01a6_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibd4aa0b2117641deace84f081e7d99ce_I20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2014-08-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i788db1d002a24118902ba114a1c848a8_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i94bfc7a6eb3c4e7f8de61d82318efc87_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4f4b2d2a5e634e08a972694ba181cfbf_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if82e065acc144b048906db168419d424_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibf06eb88f9114519b8566ae3991390c1_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i05c9c59e0a404b2384aa8481bfe4e0f8_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="idc51ddeb3e934105a34f1deb7f263b29_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iab43107ea2de411d8ec195b05082d875_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i7f9f95d1537a49879879507d3c5b2ba7_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if6d885e1e1c9488c9c8b980b72ab5539_I20180101"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AociIncludingPortionAttributableToNoncontrollingInterestMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-01-01</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201615Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201615Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:VestingAxis">lgnd:VestingPeriodOneMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:VestingAxis">lgnd:VestingPeriodTwoMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2ba96270f73845a489eec892606f151e_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:SeniorNotesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="trading_day"><xbrli:measure>lgnd:trading_day</xbrli:measure></xbrli:unit><xbrli:context id="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i0aadecee51e54de98ac550079bea27c4_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i064e8a313dcd4597a31a3e322d0fb198_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia1016c7a3fb3456dadccac23f7e35a59_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5be21f383f784dc5bdb8f26fd11bd5f8_I20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-06-19</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id3f44e4150824aac8cb8233b4f6c5332_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4a4309c3a4644756b0b0e2a41966e07d_I20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-05-22</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i019545928c8d42fa914265e7cce06db4_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i421c6d753d8042d6ba4f5dea715b2015_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4f2d6682161c4d8580620d72aac72bec_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:OwnershipAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia92a709872af454ba4a10e9e097a3942_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1495b46d310b40f39b5ba48f1a435973_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia6fd586e979f42b98e809e8789d74966_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i752433d6202a4b8d86205c212edea90e_D20180101-20180331"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-03-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iaffe39f2d0954dbd80e0485f4618b93a_D20140501-20140531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:VariableInterestEntitiesByClassificationOfEntityAxis">us-gaap:VariableInterestEntityPrimaryBeneficiaryMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DerivativeInstrumentRiskAxis">us-gaap:DebtMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2014-05-01</xbrli:startDate><xbrli:endDate>2014-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i383f1359ee76425995b33bc12c23ab90_I20160131"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-01-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-04-13</xbrli:startDate><xbrli:endDate>2016-04-13</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8c3752abd1af4925883b62910e38900f_I20170715"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-07-15</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i77dbc1a726434cedaf60137ef4ee8652_D20180523-20180523"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-23</xbrli:startDate><xbrli:endDate>2018-05-23</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if138f3f9b2b74770a5cce6db84ab24b9_I20160430"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-04-30</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia743eb727a504f64a2e98f6fafd87f67_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i487a7d2c1cd749679482b85797456924_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i07d723f5c7634c8f84df7f866754f3e9_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i38901eeb0e374312bb0a645919532284_D20181001-20181031"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-10-01</xbrli:startDate><xbrli:endDate>2018-10-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-10-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iaa145923f25048de937e04721b4c84da_D20181001-20181031"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-10-01</xbrli:startDate><xbrli:endDate>2018-10-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-10-06</xbrli:startDate><xbrli:endDate>2017-10-06</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-10-06</xbrli:startDate><xbrli:endDate>2017-10-06</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-10-06</xbrli:startDate><xbrli:endDate>2017-10-06</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="numberofcollaborationagreements"><xbrli:measure>lgnd:numberOfCollaborationAgreements</xbrli:measure></xbrli:unit><xbrli:context id="i57c56b2221e94885a3513e61361de5d2_I20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-10-06</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0a8ca3d45f2d43049621874687484bb9_I20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-10-06</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ida162efcc0e64c3698e0382c9a821d87_D20171006-20171006"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-10-06</xbrli:startDate><xbrli:endDate>2017-10-06</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-08</xbrli:startDate><xbrli:endDate>2016-01-08</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-01-08</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1523a02160ea4340b895af4cbcc28c78_I20160108"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-01-08</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i17a78122d7374267a4ec43cb6b8f9235_D20160108-20160108"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-08</xbrli:startDate><xbrli:endDate>2016-01-08</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2233588cfcdd4d1d8216daf3329f3545_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i22719832b06742dcae5a658d47223931_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i754ca8ba8ad24cac9f16597b92a3ea5f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib03a2af9f5d54545a7ec5a4137113457_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1908cb4c829d42b2844e3bb3f6368f63_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i64f8a58aefc1411cafeabef5c6a7b1fd_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie8c9c9e6cb294fdbb37cef5bce12b5c7_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i36f2d5d73c464b0db83cc19d3975cda9_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie7d6396714744e2880bfbeacc09c78a1_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib357eeae00de4b2f9b1a22317457315f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8dcdef9f22634f7090bf5d69fcdb1a55_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i337533b66aed409fbb551874229f75dc_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibd9630ec50374d25a30576be33a7d809_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iac4562685c694e1aa2783376bb16c397_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id099ffb3f70c4870880029056f3695be_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8eaac6d98c2544b09548e8e62b89c4c3_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic130ac71bf1e42c7b737b642085cce55_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia4692046f93b4663b7e83e2a8a873af5_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibcf1b8f7afc644a7b9ad7768719336a8_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i57f18aa010824bad8480819ba46172f0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if47ef23bd3e44c4993c4afa7d1be94c7_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ifcedb617c87e4dcb92d2c7b639fcd223_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0b5020617b024955ba56ec0766513aad_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8c35be238f5f4799bbc1031e24efec68_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i132a6a890ed4471ba8dcfb3ace9549a0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i3069e6dc112c4ef2a9cf5ab7ee50048d_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib61cc1114176418598c990b41c9592be_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i2fe58c083e874cab83a78bcd827e2e5f_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1b4d2c43bec54742920bd9ad32b07e48_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i30473976e3b8481aa885bb1335a889ba_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i6012dd95b4ab4dde814d5a046166d09c_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1baadb28e8b3408fa30ff77e00eec512_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1941637101594a8cabf4ba0b5e120f5e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iee4b70d2241e4511bad0987b2b407f03_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie61370b969e74487b411b5a782a4d5a1_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8bfcb6d6abee4192bca4732758d746b7_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ife3a9602a0cc4ec79c3b2bda40aa033e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i62bcebfbe2964b9da317b06464c29f89_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iee6fe34449294b25881d8dbef0b24b9a_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1c52c13365f3461ab55087c232b51f23_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0061c212e5ce4c66940a7702790b784e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i570e675c9bf14c37b7f85f189f5c58ec_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i2ae9df4c8cc94d689af9eb73b9a9fceb_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i221c7262300e453ebd7dc80f8dc71c46_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i63575e7ad8594216a6892afca9a80932_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5c6283c43ebd4c50aa4fe656936d6b4b_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia7a3efe3d1124d26b92d141e512095a0_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9bb6c8e4586348ad8838a58f65c26246_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i6a51c585db8547f0acb66bf4eb5290b7_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i929b0893ee4f41fba2a2db7c8914d4f5_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0ad5f3f765e1490fa0521acd9849999d_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i73c27a6035d749d5b1f296f7edb8ca72_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic453e34dcee74d5d9343bfeb6edf1581_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9a3fec8ff6854321a38379f92429618c_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i00244b874b5f4b12a47e76b73be3fabf_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i928d1de786ce437ebcfc3e3082b3f1b9_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i107301a7878e4cf4938d9121959d04a0_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0d5efee5821c41c0a5ea3977d0964f60_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ifa4d91631dbf46cc83d6a025d8915d6e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib09e4721ddef410299f0bd0c417261ed_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="icd248d584f1346b5b66dd780d1e9928a_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:Phase3ClinicalTrialMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ice0efd7fd9d64d719b062c5b9df1406e_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestonePaymentsAndRoyaltiesMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i921201b66b074388aa32f960d2db10cc_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ice45c867198c4943b2d8c9ed9f84c1df_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexandCrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i90f8a9db2c664665a84b2f5fadf055a6_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:CorporateHeadquartersSanDiegoCAMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeandResearchFacilityLaJollaCAMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i883212435cba47509b8b8d099bf0e1ca_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:BioscienceandTechnologyBusinessCenterLawrenceKSMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:KS</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ifa49963bd5424932b50d46aad0ed712f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeEmeryvilleCAMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i6e55f210c9ac49b5987a4861064c949d_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:ResearchFacilityEmeryvilleCAMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i354c535302b44bb19e10fe3b5a010cc8_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">country:GB</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeWinnershUnitedKingdomMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic340228d81314653a2c316604b50c401_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">country:GB</xbrldi:explicitMember><xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:ResearchFacilityCambridgeUnitedKingdomMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2014-08-01</xbrli:startDate><xbrli:endDate>2014-08-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodOneMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2014-08-01</xbrli:startDate><xbrli:endDate>2014-08-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:unit id="day"><xbrli:measure>lgnd:day</xbrli:measure></xbrli:unit><xbrli:context id="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodTwoMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2014-08-01</xbrli:startDate><xbrli:endDate>2014-08-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ic6a1014c54c4494f865d0272345aab6a_D20180522-20180522"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-22</xbrli:startDate><xbrli:endDate>2018-05-22</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i69c23a1e2fbe4523a3ca4deec08a3872_D20181231-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-12-31</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-03-01</xbrli:startDate><xbrli:endDate>2018-04-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-07-01</xbrli:startDate><xbrli:endDate>2018-08-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i75f0350fef6541038e98f82afd43a2f1_D20181001-20181130"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-10-01</xbrli:startDate><xbrli:endDate>2018-11-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i37074bf992d247a491292198d0359ff0_I20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2014-08-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i98d8d53ba8784c41bea403e9d3429ff2_D20140801-20140831"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2014-08-01</xbrli:startDate><xbrli:endDate>2014-08-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="icf42ad343571467faece802b998bf88c_D20181101-20181130"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-11-01</xbrli:startDate><xbrli:endDate>2018-11-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodOneMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-01</xbrli:startDate><xbrli:endDate>2018-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodTwoMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-01</xbrli:startDate><xbrli:endDate>2018-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i978ee51a08364e3eb7649d6141d3c780_D20180522-20180619"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-22</xbrli:startDate><xbrli:endDate>2018-06-19</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8517c8b0243e45e096978d0ca26893b0_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia32e2ae420b54b08bc61c77e24a0b664_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i60cd2ff27aee458a876ce61408c2748a_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie527761fa7b14d4e8c10a419b7c96050_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iff1b40e31eb94dd28c98c1b69495379f_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i2fb1a05c9a404a7a9804793a41837e00_D20180501-20180531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-01</xbrli:startDate><xbrli:endDate>2018-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if09401cad196425ab690698455cc8c3d_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:DemandDepositsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i68ecb47464af47feb893f53340e5806b_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CorporateDebtSecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i873cc4ad2c4a424094af1f53ee86bf32_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:EquitySecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ide49d3899c314c7a83ca6827111b97cd_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CommercialPaperMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i40f8bac802b34bae87d73215caf27338_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USTreasurySecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="icbfd2d77cfdb42909cec6fea6491ed92_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:MunicipalBondsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ibe5aa361660c49aa9ade65790e60db3b_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i843b12a2426b42a0a044c4840af01886_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:DemandDepositsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CorporateDebtSecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9251dd4d31b7498093e1f44f4c5947dc_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:EquitySecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i314bde6d607f4e658a119ca41affb344_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CommercialPaperMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i08498294a183499a9bf71fb60b17b954_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USGovernmentAgenciesDebtSecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9c4120046acd4fc69f355bb557d7c4d1_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USTreasurySecuritiesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if120a59cc3604cb3ad3491acaa5c4d79_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:MunicipalBondsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iac339cad857c45998c60f10b6d6bf7da_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i16fdeb617d3e4ad69654c02d20dca967_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:OfficeEquipmentMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iac24af30dd5947d69f092c0143c72cd5_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:OfficeEquipmentMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i4e5237e21cd94cbe8fb403d08bacef1f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:LeaseholdImprovementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5d2d421f80254076b1c05f7d56f73e55_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:LeaseholdImprovementsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic146a47155124f8587de68b7f7bf2916_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">lgnd:ComputerEquipmentAndSoftwareMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i2f59fb3a08394604ad40621952d209ac_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">lgnd:ComputerEquipmentAndSoftwareMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if00b0dbd22ec4957944d58677bc41590_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IndefiniteLivedIntangibleAssetsByMajorClassAxis">lgnd:AcquiredInProcessResearchAndDevelopmentMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:PatentedTechnologyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i17da7efba5044964a299fa1b88c45d89_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:PatentedTechnologyMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i25a1b9803d204d8399b4072bc7f1feba_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:TradeNamesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i098eec66c5b3403da1e52d65ba40fb09_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:TradeNamesMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:CustomerRelationshipsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ida0878f2976a419ab990ac37bb697cf4_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:CustomerRelationshipsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ic732878aa6064bd6999a01fcb26ffafb_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i7a2d42893cd644a68777988972f1db82_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="idfb5b3bf1daa4956a0677ba6e2b17a09_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6555f01d1e2a414bb4602de9db064582_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i04a307d0dd25404c9e1b6973b4fcfcfc_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib90242a1f1084a72890da4139394161b_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i962f4a871df84f71a3762aabb69d87d4_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i5a6f5527bcd749ebb994ee78a83dec16_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i3ddcb2326de24ff388c9dabc96f2f7ab_I20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2016-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia96387c68e204b4388e9977b060ff288_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i3dc153fa027840bfaf8d39d7777fca8a_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="idaab1982bed149178b9a7a902d4ec9b1_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i5525fb7204b24ebb9a94c522e3490ed3_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i660b0db80fb243a9aa215587f3e20997_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6387378ce4f1495fbf9934bbc7f8004b_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i008883d729b243ce80c4af9827bf6117_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i9e6c1c39ab414f958545d7f4f2e968ea_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8122f73ad096454d8683e1fb385d450f_D20120530-20120531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2012-05-30</xbrli:startDate><xbrli:endDate>2012-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i10821c8abf4c413496e40313cc3d82c6_D20160501-20160531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-05-01</xbrli:startDate><xbrli:endDate>2016-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iefc813acbb6448ec99d57a49fe36770e_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i02a0eae6ee8f45419024489126f96d62_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeOneMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeOneMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTwoMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ie821bbf2318f4f019ee636621375f551_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTwoMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="iaaac9c476ecc4afaa2ed93f40a060882_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeThreeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeThreeMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFourMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFourMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if74d2c0621f34efba8080e1e9711fb35_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFiveMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFiveMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia88d9bb235ee4445acd17f3571976ef0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSixMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i92faeba614e34b3493a599209d077a07_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSixMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i161b18328a8442d6997ff80696b788bd_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSevenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSevenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i4246c537469d483abd783cecc40379d0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeNineMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeNineMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i5974c3104a5d4b21bf3baa514858efa2_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="icd529d0655ba4752b67e7314f7cc06f6_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeEightMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeEightMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="icf71bbc4ad954da9bce0e233b086c8bb_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeElevenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeElevenMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia0d63b23666041d7a8b08537e54a6d2c_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="id920233585164484842655792fe0311e_I20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2017-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i5049cfdd90d748e48259538705c3a2a0_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ic36cfb515c93422e90d0bdcd8bd0ebee_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i6ec79fc5ae034975bdc7a82825400a68_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-05-01</xbrli:startDate><xbrli:endDate>2018-05-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ibb568ab64b614ed6a1e37b60e92b6fef_I20150930"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:instant>2015-09-30</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if2c884f969ea4a8c957cc0b0ecc3ad55_I20190123"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2019-01-23</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i0f29d3370c15467eae1d22610a661a7f_D20190101-20190228"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2019-01-01</xbrli:startDate><xbrli:endDate>2019-02-28</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ia523a50a3e1f4636a3f2c5181779d8ee_I20190228"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2019-02-28</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ia5b28253139449d098c85223a0ec523b_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="icf48f425fe72411f84259887a606949c_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:startDate>2016-01-01</xbrli:startDate><xbrli:endDate>2016-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i8f913262edf243adae4d2f256243ef16_D20150901-20150930"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2015-09-01</xbrli:startDate><xbrli:endDate>2015-09-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ie84f0fb144ed4ec5926cfdf7ba32b2bb_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeTaxAuthorityAxis">us-gaap:InternalRevenueServiceIRSMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="if81fb0e1a8ac48909d921d4552f44684_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:IncomeTaxAuthorityAxis">us-gaap:StateAndLocalJurisdictionMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="ib8f1f80b43fe48948dc666b8a2639468_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:TaxCreditCarryforwardAxis">us-gaap:ResearchMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i1426778bb59d4208adce54ccb7e0983f_I20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier><xbrli:segment><xbrldi:explicitMember dimension="us-gaap:TaxCreditCarryforwardAxis">lgnd:CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember</xbrldi:explicitMember></xbrli:segment></xbrli:entity><xbrli:period><xbrli:instant>2018-12-31</xbrli:instant></xbrli:period></xbrli:context><xbrli:context id="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2017-01-01</xbrli:startDate><xbrli:endDate>2017-03-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i629fd315f0344d618e896741a9894704_D20170401-20170630"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2017-04-01</xbrli:startDate><xbrli:endDate>2017-06-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2017-07-01</xbrli:startDate><xbrli:endDate>2017-09-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2017-10-01</xbrli:startDate><xbrli:endDate>2017-12-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-01-01</xbrli:startDate><xbrli:endDate>2018-03-31</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-04-01</xbrli:startDate><xbrli:endDate>2018-06-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-07-01</xbrli:startDate><xbrli:endDate>2018-09-30</xbrli:endDate></xbrli:period></xbrli:context><xbrli:context id="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0000886163</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2018-10-01</xbrli:startDate><xbrli:endDate>2018-12-31</xbrli:endDate></xbrli:period></xbrli:context><ix:relationship arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote" fromRefs="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7 id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8" linkRole="http://www.xbrl.org/2003/role/link" toRefs="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62" order="1"></ix:relationship></ix:resources></ix:header></div><div id="i_0_1"></div><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-top:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">UNITED STATES</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;font-weight:700;line-height:120%;">SECURITIES AND EXCHANGE COMMISSION</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">Washington, D.C. 20549</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6pt;font-weight:700;line-height:120%;">_____________________________________________________________________________________________</span></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">FORM <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="dei:DocumentType" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y18xMzE5NDEzOTUzNzgxOQ_2f9ba401-e386-407e-a595-4ff50d630194" escape="true">10-K</ix:nonNumeric></span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6pt;font-weight:700;line-height:120%;">_____________________________________________________________________________________________</span></div><div style="margin-top:2pt;"><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:0.1%;"></td><td style="width:1.672316%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:99.271186%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:11pt;font-weight:400;font-family:Wingdings;color:#000000;background-color:rgb(255,255,255, 0.0);">x</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:11pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934</span></td></tr></table></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">For the Fiscal Year Ended December&#160;31, 2018</span></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">OR</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:0.1%;"></td><td style="width:1.672316%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:99.271186%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:11pt;font-weight:400;font-family:Wingdings;color:#000000;background-color:rgb(255,255,255, 0.0);">o</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:11pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934</span></td></tr></table></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">For the transition period from &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; to &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;.</span></div><div style="text-align:center;margin-top:2pt;"><span><br/></span></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Commission File No.&#160;001-33093</span></div><div style="text-align:center;margin-top:2pt;"><span><br/></span></div><div style="text-align:center;margin-top:2pt;"><img src="lgnd-20181231_g1.gif" alt="lgnd-20181231_g1.gif" style="height:70;width:194;"></img></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:120%;">(Exact name of registrant as specified in its charter)</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:50.118644%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.506215%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:50.118644%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">77-0160744</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">(State or other jurisdiction of</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">incorporation or organization)</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">(IRS Employer</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Identification No.)</span></div></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">3911 Sorrento Valley Boulevard, Suite 110</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">San Diego, CA</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">92121&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Address of Principal Executive Offices)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Zip Code)</span></td></tr></table></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">Registrant&#8217;s telephone number, including area code: (858)&#160;550-7500</span></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">Securities registered pursuant to Section&#160;12(b) of the Act:</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:55.344633%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:45.598870%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);text-decoration: underline;">Title of Each Class</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);text-decoration: underline;">Name of Each Exchange on Which Registered</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common Stock, par value $.001 per share</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">The&#160;Nasdaq&#160;Global&#160;Market&#160;of&#160;The&#160;Nasdaq&#160;Stock&#160;Market&#160;LLC</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr></table></div><div style="text-align:center;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">Securities registered pursuant to Section&#160;12(g) of the Act:</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">None</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.&#160;&#160;&#160;&#160;Yes&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;line-height:120%;">x</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;&#160;&#160;&#160;No&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;line-height:120%;">o</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Indicate by check mark if the registrant is not required to file reports pursuant to Section&#160;13 or Section&#160;15(d) of the Securities Exchange Act of 1934.&#160;&#160;&#160;&#160;Yes&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;line-height:120%;">o</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;&#160;&#160;&#160;No&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;line-height:120%;">x</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">I</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">ndicate by check mark whether the registrant: (1)&#160;has filed all reports required to be filed by Section&#160;13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2)&#160;has been subject to such filing requirements for the past 90 days.&#160;&#160;&#160;&#160;Yes&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">x</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;&#160;&#160;&#160;No&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">o</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Indicate by check mark whether the registrant has submitted electronically&#160;every Interactive Data File required to be submitted pursuant to Rule 405 of Regulation S-T (&#167; 232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit such files).&#160;&#160;&#160;&#160;Yes&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">x</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;&#160;&#160;&#160;No&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">o</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Indicate by check mark if disclosure of delinquent filers pursuant to Item&#160;405 of Regulation S-K is not contained herein, and will not be contained, to the best of registrant&#8217;s knowledge, in definitive proxy or information statements incorporated by reference in Part III of this Form 10-K or any amendment to this Form 10-K.&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">o</span></div><div style="margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See definition of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221;  &#8220;smaller reporting company&#8221; and "emerging growth company" in Rule 12b-2 of the Exchange Act. </span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.011299%;"><tr><td style="width:1.0%;"></td><td style="width:16.972896%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.513267%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:15.118402%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:16.972896%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:19.968616%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:20.253923%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Large&#160;Accelerated&#160;Filer&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;font-weight:400;line-height:100%;">x</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Accelerated&#160;Filer &#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;font-weight:400;line-height:100%;">o</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Non-accelerated&#160;Filer&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;font-weight:400;line-height:100%;">o</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Smaller&#160;reporting&#160;company&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;font-weight:400;line-height:100%;">o</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Emerging growth&#160;company&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:8pt;font-weight:400;line-height:100%;">o</span></div></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="9" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-indent:18pt;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">o</span></div><div style="text-indent:18pt;margin-top:2pt;"><span><br/></span></div><div style="text-indent:18pt;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Indicate by check mark whether the registrant is a shell company (as defined in Exchange Act Rule 12b-2 of the Exchange Act).&#160;&#160;&#160;&#160;Yes&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">o</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;&#160;&#160;&#160;No&#160;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:9pt;line-height:120%;">x</span></div><div style="text-indent:18pt;margin-top:2pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:18pt;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">The aggregate market value of the Registrant&#8217;s voting and non-voting stock held by non-affiliates was approximately&#160;$<ix:nonFraction unitRef="usd" contextRef="i57786fa40fdb47bdb16a704aefea1269_I20180630" decimals="-8" format="ixt:numdotdecimal" name="dei:EntityPublicFloat" scale="9" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y181NDk3NTU4MTgzNDY_77fa71da-cd78-436d-9549-96c81c6550e0">3.6</ix:nonFraction> billion&#160;based on the last sales price of the Registrant&#8217;s Common Stock on the Nasdaq Global Market of the Nasdaq Stock Market LLC on June&#160;29, 2018. For purposes of this calculation, shares of Common Stock held by directors, officers and 10% stockholders known to the Registrant have been deemed to be owned by affiliates which should not be construed to indicate that any such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant or that such person is controlled by or under common control with the Registrant.</span></div><div style="text-indent:18pt;margin-top:2pt;"><span><br/></span></div><div style="text-indent:18pt;margin-top:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">As of February&#160;25, 2019, the Registrant had&#160;<ix:nonFraction unitRef="shares" contextRef="i7732d073cf4e48638e3a966a3396d67c_I20190225" decimals="INF" format="ixt:numdotdecimal" name="dei:EntityCommonStockSharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y181NDk3NTU4MTgyMzA_4507b81a-665b-4980-b218-1c07d8243df3">20,445,407</ix:nonFraction>&#160;shares of Common Stock outstanding.</span></div><div style="text-indent:18pt;margin-top:2pt;"><span><br/></span></div><div style="text-align:center;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">DOCUMENTS INCORPORATED BY REFERENCE</span></div><div style="text-align:center;margin-top:5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">Portions of the Proxy Statement for the Registrant&#8217;s 2019 Annual Meeting of Stockholders to be filed with the Commission within 120 days of December&#160;31, 2018 are incorporated by reference in Part&#160;III of this Annual Report on Form&#160;10-K.&#160;With the exception of those portions that are specifically incorporated by reference in this Annual Report on Form&#160;10-K, such Proxy Statement shall not be deemed filed as part of this Report or incorporated by reference herein.</span></div><div style="margin-top:2pt;"><span><br/></span></div><div style="text-indent:18pt;margin-top:2pt;"><span><br/></span></div><div id="i_0_27"></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Table of Contents</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:6.211144%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:83.923754%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:3.865103%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Part I</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;1.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_53">Business</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_53">5</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;1A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_65">Risk Factors</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_65">23</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;1B.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_77">Unresolved Staff Comments</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_77">32</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;2.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_89">Properties</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_89">32</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;3.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_101">Legal Proceedings</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_101">33</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;4.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_113">Mine Safety Disclosures</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_113">33</a></span></div></td></tr><tr><td colspan="6" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Part II</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;5.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_137">Market for Registrant&#8217;s Common Equity, Related Stockholder Matters, and Issuer Purchases of Equity Securities</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_137">33</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;6.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_149">Selected Consolidated Financial Data</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_149">34</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;7.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_161">Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_161">36</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;7A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_209">Quantitative and Qualitative Disclosures About Market Risk</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_209">44</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;8.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_221">Consolidated Financial Statements and Supplementary Data</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_221">45</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;9.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_543">Changes in and Disagreements with Accountants on Accounting and Financial Disclosure</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_543">82</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;9A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_555">Controls and Procedures</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_555">82</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item 9B.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_756">Other Information</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_555">82</a></span></div></td></tr><tr><td colspan="6" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Part III</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;10.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_580">Directors, Executive Officers and Corporate Governance</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_580">85</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;11.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_592">Executive Compensation</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_592">85</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;12.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_604">Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_604">85</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;13.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_616">Certain Relationships and Related Transactions, and Director Independence</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_616">85</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;14.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_628">Principal Accountant Fees and Services</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_628">85</a></span></div></td></tr><tr><td colspan="6" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Part IV</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;15.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_653">Exhibits, Financial Statement Schedules</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_653">86</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item 16.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_702">Form 10K - Summary</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_653">86</a></span></div></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_666">Signatures</a></span></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_666">91</a></span></div></td></tr></table></div><div style="text-indent:24pt;margin-top:9pt;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.543860%;"><tr><td style="width:1.0%;"></td><td style="width:25.804107%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:70.195893%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:25pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GLOSSARY OF TERMS AND ABBREVIATIONS&#160;</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Abbreviation&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Definition&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2019 Notes&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$245.0 million aggregate principal amount of convertible senior unsecured notes due 2019&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2023 Notes&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$750.0 million aggregate principal amount of convertible senior unsecured notes due 2023&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AACR&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">American Association for Cancer Research&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ADHF&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Acute decompensated heart failure&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Amended Interest Purchase Agreement</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Amended and Restated Interest Purchase Agreement, dated May 31, 2017, between the Company and CorMatrix Cardiovascular, Inc.</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aldeyra</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aldeyra Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AMD</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Age-related macular degeneration&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amgen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amgen, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ANDA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Abbreviated New Drug Application&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">API&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Active pharmaceutical ingredient</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Apricus </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Apricus Biosciences, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aptevo</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aptevo Therapeutics&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Arcus </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Arcus Biosciences, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASC</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounting Standards Codification&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASCO</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">American Society of Clinical Oncology&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASCT</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Autologous Stem Cell Transplantation</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASH&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">American Society of Hematology&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounting Standards Update &#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo Med, LLC&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Azure&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Azure Biotech, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Baxter&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Baxter International, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">BiTE</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Bispecific T cell engager</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BMS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Bristol Myers Squibb&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">C-Stone</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">CStone Pharmaceuticals Co., Ltd. </span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CASI&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CASI  Pharmaceuticals, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cardioxyl&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cardioxyl Pharmaceuticals, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Code of Conduct</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Code of Conduct and Ethics Policy</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Coherus</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Coherus Biosciences, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Composition of Matter</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Company&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Pharmaceuticals Incorporated, including subsidiaries&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Convertible Note</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Senior Convertible Promissory Note</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">COPD&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Chronic obstructive pulmonary disease &#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cormatrix&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Cormatrix Cardiovascular Inc. </span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Cormatrix Asset Sale</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Asset sale from CorMatrix to Aziyo</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corvus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corvus Pharmaceuticals, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">COSO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Committee of Sponsoring Organizations of the Treadway Commission&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CRO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contract Research Organization&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal Bioscience, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CStone</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CStone Pharmaceuticals</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CURx</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CURx Pharmaceuticals, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CVR&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contingent value right&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CyDex</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CyDex Pharmaceuticals, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Daiichi Sankyo</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Daiichi Sankyo Company, LTD</span></div></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.543860%;"><tr><td style="width:1.0%;"></td><td style="width:25.804107%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:70.195893%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dianomi&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dianomi Therapeutics&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">DMF&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Drug Master File&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Eisai</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Eisai Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Eli Lilly</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Eli Lilly and Company</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EMC</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Extracellular matrix</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EPOR</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Erythropoietin receptor</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ESPP</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Employee Stock Purchase Plan, as amended and restated&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">European Union&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Exelixis </span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Exelixis, Inc.</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FASB&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Financial Accounting Standards Board&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FDA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Food and Drug Administration&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fred Hutch&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">The Fred Hutchinson Cancer Research Center&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FSGS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Focal segmental glomerulosclerosis&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GAAP</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Generally accepted accounting principles in the United States</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GCSF</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granulocyte-colony stimulating factor</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GRA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Glucagon receptor antagonist </span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">HanAll</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HanAll Biopharma Co., Ltd.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Harbour&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Harbour BioMed</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HCO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Heavy-chain-only</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HNO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Nitroxyl</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Hovione&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Hovione FarmCiencia</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IPR&amp;D&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">In-Process Research and Development&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IRAK4</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interleukin-1 Receptor Associated Kinase-4</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IRS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Internal Revenue Service&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ITP&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Chronic immune (idiopathic) thrombocytopenic purpura&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IV&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Intravenous&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">iMBP&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">iMetabolic Biopharma Corporation &#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Immunovant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Immunovant Sciences GmbH</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IND&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investigational New Drug&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Original Interest Purchase Agreement</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Interest Purchase Agreement, dated May 3, 2016, between the Company and CorMatrix Cardiovascular, Inc.</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">KSQ Therapeutics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">KSQ Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Pharmaceuticals Incorporated, including subsidiaries&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Loan and Security Agreement </span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Loan and Security Agreement, dated May 21, 2014, between the Company and Viking, as amended by the First Amendment to Loan and Security Agreement, dated April 8, 2015, and the Second Amendment to Loan and Security Agreement, dated January 22, 2016</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LTP&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liver-targeted prodrug&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lundbeck&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lundbeck A/S&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Marinus </span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Marinus Pharmaceuticals, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MCM&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Mineral Coated Microparticle&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MDS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Myelodysplastic syndromes&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Melinta&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Melinta Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merck&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merck &amp; Co., Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merrimack</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merrimack Pharmaceuticals, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Metavant</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metavant Sciences&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MLA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Master License Agreement&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MRSA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Methicillin-resistant Staphylococcus aureu&#160;</span></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.543860%;"><tr><td style="width:1.0%;"></td><td style="width:25.804107%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:70.195893%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NASH&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Non-alcoholic steatohepatitis</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NDA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">New Drug Application&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NOLs&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net Operating Losses&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novartis AG</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OMT&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Open Monoclonal Technology, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Omthera&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Omthera Pharmaceuticals, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ono&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ono Pharmaceutical Co., Ltd.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Orange Book&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Publication identifying drug products approved by the FDA based on safety and effectiveness</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Par&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Par Pharmaceutical, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PDUFA</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Prescription Drug User Fee Act</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pharmacopeia</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pharmacopeia, Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phoenix Tissue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phoenix Tissue Repair</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PPD</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Post-Partum Depression</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PSU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Performance stock unit</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Roivant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Roivant Sciences GMBH&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RSU &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted stock unit&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SAA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Severe Aplastic Anemia&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SAGE&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sage Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SARM&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selective Androgen Receptor Modulator&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SEC&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Securities and Exchange Commission&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor Pharmaceuticals, Inc., or RODES, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis, SA&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sermonix</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sermonix Pharmaceuticals, LLC</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Spectrum&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Spectrum Pharmaceuticals, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sunshine Lake Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sunshine Lake Pharma Co., Ltd.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Syros &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Syros Pharmaceuticals, Inc. &#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Takeda</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Takeda Pharmaceuticals Company Limited</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax Act</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">The Tax Cuts and Jobs Act</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teva</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teva Pharmaceuticals USA, Inc., Teva Pharmaceutical Industries Ltd. and Actavis, LLC </span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TG Therapeutics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TG Therapeutics, Inc.&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TPE&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Third-party evidence&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TR-Beta</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Thyroid hormone receptor beta</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VDP</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">Vernalis Design Platform</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VentiRx</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VentiRx Pharmaceuticals Inc.</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis plc&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Verona&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Verona Pharma plc&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking Therapeutics</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vireo</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vireo Health</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">WuXi&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">WuXi Biologics Ireland Limited&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">WuXi Agreement</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">The Platform License Agreement, dated March 23, 2015, by and between Ligand and WuXi, as amended</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X-ALD&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X-linked adrenoleukodystrophy&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Zydus Cadila</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Zydus Cadila Healthcare Ltd</span></td></tr></table></div><div style="margin-top:9pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div id="i_0_39"></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">PART I</span></div><div style="text-indent:27pt;"><span><br/></span></div><div id="i_0_53"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;text-decoration: underline;">Cautionary Note Regarding Forward-Looking Statements</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">: </span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">You should read the following report together with the more detailed information regarding our company, our common stock and our financial statements and notes to those statements appearing elsewhere in this document. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">This report contains forward-looking statements that involve a number of risks and uncertainties. Although our forward-looking statements reflect the good faith judgment of our management, these statements can only be based on facts and factors currently known by us. Consequently, these forward-looking statements are inherently subject to risks and uncertainties, and actual results and outcomes may differ materially from results and outcomes discussed in the forward-looking statements.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Forward-looking statements can be identified by the use of forward-looking words such as &#8220;believes,&#8221; &#8220;expects,&#8221; &#8220;may,&#8221; &#8220;will,&#8221; &#8220;plan,&#8221; &#8220;intends,&#8221; &#8220;estimates,&#8221; &#8220;would,&#8221; &#8220;continue,&#8221; &#8220;seeks,&#8221; &#8220;pro forma,&#8221; or &#8220;anticipates,&#8221; or other similar words (including their use in the negative), or by discussions of future matters such as those related to our future results of operations and financial position, royalties and milestones under license agreements, Capitsol material sales, product development,  and product regulatory filings and approvals, and the timing thereof, as well as other statements that are not historical. You should be aware that the occurrence of any of the events discussed under the caption &#8220;Risk Factors&#8221; could negatively affect our results of operations and financial condition and the trading price of our stock.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">The cautionary statements made in this report are intended to be applicable to all related forward-looking statements wherever they may appear in this report. We urge you not to place undue reliance on these forward-looking statements, which speak only as of the date of this report. Except as required by law, we assume no obligation to update our forward-looking statements, even if new information becomes available in the future. This caution is made under the safe harbor provisions of Section&#160;21E of the Securities Exchange Act of 1934, as amended.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">References to &#8220;Ligand Pharmaceuticals Incorporated,&#8221; &#8220;Ligand,&#8221; the &#8220;Company,&#8221; &#8220;we,&#8221; &#8220;our&#8221; and &#8220;us&#8221; include Ligand Pharmaceuticals Incorporated and our wholly-owned subsidiaries.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:115%;">Partner Information</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Information regarding partnered products and programs comes from information publicly released by our partners and licensees.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Trademarks</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our trademarks, trade names and service marks referenced herein include Ligand&#174;, Captisol&#174;, Captisol-enabled&#8482;, LTP technology&#8482;, OmniAb&#174;, OmniMouse&#174;, OmniRat&#174;, OmniFlic&#174; and OmniChickenTM&#160;which are protected under applicable intellectual property laws and are our property. All other trademarks, trade names and service marks including BaxdelaTM, CarnexivTM, Conbriza&#174;, Duavee&#174;, Evomela&#174;,Kyprolis&#174;, Promacta&#174;, Revolade&#174;, SUREtechnology Platform&#8482;, Viviant&#174;, Vivitra&#174;, Bryxta&#174;, and Exemptia&#174; are the property of their respective owners. Solely for convenience, trademarks, trade names and service marks referred to in this report may appear without the &#174;, &#8482; or SM symbols, but such references are not intended to indicate, in any way, that we will not assert, to the fullest extent under applicable law, our rights or the right of the applicable licensor to such trademarks, trade names and service marks. Use or display by us of other parties&#8217; trademarks, trade dress or products is not intended to and does not imply a relationship with, or endorsement or sponsorship of, us by the trademark or trade dress owners.</span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span><br/></span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-top:14pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;1.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Business</span></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Overview</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We are a biopharmaceutical company focused on developing and acquiring technologies that help pharmaceutical companies discover and develop medicines. Over our more than 30 year history, we have employed research technologies such as nuclear receptor assays, high throughput computer screening, formulation science, liver targeted pro-drug technologies and antibody discovery technologies to assist companies in their work toward securing prescription drug approvals. We currently have partnerships and license agreements with over 110 pharmaceutical and biotechnology companies. Over&#160;200 different programs under license with us are currently in various stages of commercialization and development. We have contributed novel research and technologies for approved medicines that treat cancer, osteoporosis, fungal infections and low blood platelets, among others.  Our partners have programs currently in clinical development targeting seizure, coma, cancer, diabetes, cardiovascular disease, muscle wasting, liver disease, and kidney disease, among others.  We have over 1,200 issued patents worldwide.</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">We&#160;have assembled our large portfolio of fully-funded programs either by licensing our own proprietary drug development programs, licensing our platform technologies such as Captisol or OmniAb to partners for use with their proprietary programs, or acquiring existing partnered programs from other companies. Fully-funded programs, which we refer to as "shots on goal," are those for which our partners pay all of the development and commercialization costs. For our internal programs, we generally plan to advance drug candidates through early-stage drug development or clinical proof-of-concept&#160;and then seek partners to continue development and potential commercialization.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our business model creates value for stockholders by providing a diversified portfolio of biotech and pharmaceutical product revenue streams that are supported by an efficient and low corporate cost structure. Our goal is to offer investors an opportunity to participate in the promise of the biotech industry in a profitable, diversified and lower-risk business than a typical biotech company. Our business model is based on doing what we do best: drug discovery, early-stage drug development, product reformulation and partnering. We partner with other pharmaceutical companies to leverage what they do best (late-stage development, regulatory management and commercialization) to ultimately generate our revenue. We believe that focusing on discovery and early-stage drug development while benefiting from our partners&#8217; development and commercialization expertise will reduce our internal expenses and allow us to have a larger number of drug candidates progress to later stages of drug development.</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our revenue consists of three primary elements: royalties from commercialized products, license and milestone payments and sale of Captisol material. In addition to discovering and developing our own proprietary drugs, we selectively pursue acquisitions to bring in new assets, pipelines, and technologies to aid in generating additional potential new revenue streams.</span></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:174%;">2018 and Recent Major Business Highlights</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:174%;">Acquisitions and Other Business Development</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">In October 2018, we acquired Vernalis, a structure-based drug discovery biotechnology company with a broad pipeline of partnered programs and ongoing collaborations for $43 million in cash. The acquisition of Vernalis provided us with </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">more than eight fully-funded shots on goal, a 70-person research and development team based in Cambridge, England working on a portfolio of collaborations that have the potential to create additional shots on goal, a compound library of unpartnered programs for potential development and out-licensing, and England-based operations that provide a platform to help efficiently pursue investment and acquisition activities in Europe and the United Kingdom.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">I</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">n December 2018, we announced the acquisition of economic rights to PTX-022 from Palvella for $10 million in cash. We will receive a tiered net sales royalty in the mid-to-upper single digits on any net sales of PTX-022, as well as regulatory and financing milestones. PTX-022 is a novel, orphan-indicated, topical formulation of rapamycin in Phase 2/3 development for the treatment of pachyonychia congenita, a rare skin disorder with no FDA-approved treatment.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">In January 2019, we announced an investment in Dianomi, paying a total of $3 million in exchange for a tiered royalty of 2%-3% based on net sales for the first five products to be approved using Dianomi&#8217;s patented MCM technology and a loan convertible into $1 million of equity at Dianomi&#8217;s next qualified financing.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">In March 2018, w</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">e announced the signing of a license agreement granting Roivant exclusive global rights to develop and commercialize LGD-6972 (now named RVT-1502), the&#160;GRA which we developed through a successful Phase 2 clinical trial. Under the terms of the agreement, we received a $20 million upfront license fee, and are eligible to receive up to an additional $528.8 million of milestone payments and tiered royalties ranging from low double digits to the mid-teens, with the top tier applying to annual net sales above $3 billion. Roivant is responsible for all costs related to the program.</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">1</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">We expanded the distribution </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">capacity on Captisol. In addition to shipping commercial and clinical material out of our contract manufacturing sites in both Portugal and Ireland last year, we also established a new distribution capability in Ireland in 2018. </span></div><div style="text-align:justify;"><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Selected Late-Stage Clinical Developments</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Retrophin announced that the first patient was dosed in a global, pivotal Phase 3 clinical trial evaluating the long-term nephroprotective potential of sparsentan for the treatment of IgA nephropathy.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Retrophin presented new data examining the long-term effects of sparsentan in FSGS at the American Society of Nephrology Kidney Week 2018, and announced that the </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Journal of the American Society of Nephrology published online the positive results from Retrophin&#8217;s Phase 2 DUET study of sparsentan for the treatment of FSGS. </span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">R</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">etrophin announced that the United States Patent and Trademark Office issued a new patent providing coverage for the use of sparsentan in the treatment of IgAN and broadening the existing coverage to include all doses of sparsentan between 200 and 800 mg/day. The patent has a stated expiration date of March 30, 2030.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Melinta Therapeutics announced positive topline results from its Phase 3 trial of Baxdela&#8482; for the treatment of adult patients with community-acquired bacterial pneumonia.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Viking</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> presented positive results from a 12-week Phase 2 study of VK2809 in patients with non-alcoholic fatty liver disease in an oral late-breaker presentation at the AASLD&#8217;s annual meeting in San Francisco, CA.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Viking </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">presented positive results from its Phase 2 study of VK5211 in patients recovering from hip fracture at the American Society for Bone and Mineral Research 2018 annual meeting.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Aldeyra announced enrollment of the first patient in a Phase 3 clinical trial of topical ocular reproxalap for the treatment of allergic conjunctivitis.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Aldeyra also announced that the last patient has been dosed in a Phase 2b clinical trial of topical ocular reproxalap in dry eye disease.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Sermonix announced FDA acceptance of its IND application and the initiation of a 100-patient Phase 2 trial of oral lasofoxifene for the treatment of metastatic breast cancer. Sermonix also announced the presentation of three posters for oral lasofoxifene in metastatic breast cancer at the 2018 San Antonio Breast Cancer Symposium.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Verona</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;announced enrollment of the last patient in its Phase 2 clinical trial evaluating the effect of nebulized ensifentrine (RPL554) as an add-on to dual therapy using long-acting anti-muscarinic / long-acting beta2-agonists and triple therapy in the maintenance treatment of patients with moderate to severe COPD.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Verona </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">announced initiation of a Phase 2 clinical trial to evaluate the pharmacokinetic profile, efficacy and safety of a dry powder inhaler formulation of ensifentrine in patients with moderate-to-severe COPD.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Merrimack announced</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> a poster presentation related to seribantumab at the 2018 ASCO Annual Meeting. </span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Marinus</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;announced&#160;positive results from its Phase 2 clinical trial evaluating ganaxolone IV in women with postpartum depression.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Opthea</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;reported that the last patient was enrolled in its ongoing Phase 2b trial of OPT-302 for wet age-related macular degeneration.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Selected Regulatory Developments</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Novartis announced that the FDA expanded the label for Promacta (eltrombopag) to include first-line treatment for adults and pediatric patients two years and older with SAA in combination with standard immunosuppressive therapy.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Novartis announced results of a retrospective, real-world evidence study in patients with ITP treated with Promacta/Revolade (eltrombopag), compared with other second-line therapies, demonstrating that patients experienced better clinical outcomes with Promacta in terms of fewer bleeding episodes.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">On October 1, 2018, Amgen announced that the FDA approved the supplemental NDA to expand the prescribing information for Kyprolis to include a once-weekly dosing option in combination with dexamethasone for patients with relapsed or refractory multiple myeloma. </span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">CASI Pharmaceuticals announced that it received National Medical Products Administration (formerly, the China FDA) approval of EVOMELA for use as a high-dose conditioning treatment prior to hematopoietic progenitor (stem) cell transplantation in patients with multiple myeloma, and the palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Daiichi Sankyo announced receipt of marketing approval in Japan for MINNEBRO (esaxerenone) for the treatment of hypertension.</span></div><div style="text-indent:-18pt;padding-left:27pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">S</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">AGE&#160;announced that the FDA Psychopharmacologic Drugs Advisory Committee and Drug Safety and Risk Management Advisory Committee jointly voted that data support the favorable benefit-risk profile of Zulresso injection for the treatment of postpartum depression. SAGE also announced on November 20, 2018 that the PDUFA action date for the NDA for ZULRESSO is March 19, 2019.</span></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">2</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Disclosed Licensing Deals Entered into or Expanded</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">OmniAb Technology</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">We announced receipt of a $47 million payment as a result of signing an amendment related to our OmniAb platform license agreement with WuXi. Under the amended agreement, we will continue to be eligible to earn royalties at the same rate and terms as the previous agreement and the predefined contract payments have been eliminated. With this new business relationship, WuXi believes it will be able to increase the number of OmniAb antibodies it discovers for its clients in China and around the world.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Worldwide license agreements with venBio Partners, Ferring Pharmaceuticals and Glenmark Pharmaceuticals to use the OmniAb platform technologies to discover fully human antibodies. The agreement with venBio permits the venture capital firm&#8217;s portfolio companies to enter into worldwide OmniAb platform agreements under previously agreed-upon terms. We are eligible to receive annual access payments, milestone payments and royalties on future net sales of any antibodies discovered under these licenses.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">We entered into OmniChicken license expansions with FivePrime and Amgen, allowing the companies to use the OmniChicken technology.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Worldwide</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> license agreement with iMBP to use the OmniAb platform technologies to discover fully&#160;human antibodies. iMBP is an early-stage company with experienced leadership and proprietary research based on&#160;functional preservation of key natural enzymes responsible for lipid metabolism.&#160;Their discovery-stage programs target&#160;obesity and related diseases, with a primary focus on hyperlipidemia. We are eligible to receive a tiered royalty on&#160;future sales of up to 6%. As part of the agreement, we will fund and facilitate select early antibody discovery activities,&#160;and in return will receive an equity ownership position in iMBP.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">OmniAb platform license agreement with </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Fred Hutch to use the OmniAb rodent platform technologies to discover fully human antibodies. We are eligible to receive a defined share of revenue received by Fred Hutch from companies that commercialize products incorporating any such OmniAb-derived antibody.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">R</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">esearch and development agreement with Janssen Pharmaceuticals for the development by Ligand of a HCO version of OmniChicken, for which we are eligible to earn defined milestone payments. Upon completion of the project, we will be able to make the HCO OmniChicken available to other commercial partners.</span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Captisol Technology</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">Captisol</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;clinical use license agreements with Sunshine Lake Pharmaceuticals, Merck KGaA and&#160;reVision&#160;Therapeutics.</span></div><div><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Additional Pipeline and Partner Developments</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">CStone announced two pivotal Phase 2 studies exploring the efficacy and safety of OmniAb-derived CS1001 in patients with natural killer cell/T-cell lymphoma and classical Hodgkin's lymphoma have been initiated and have each enrolled and dosed the first patient.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">CStone announced a collaboration agreement with Blueprint Medicines to initiate a proof-of-concept clinical trial in China evaluating BLU-554 in combination with OmniAb-derived CS1001.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">CStone also announced the completion of a $260 million series B financing that will primarily fund clinical development of OmniAb-derived CS1001.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">Aptevo announced that the first patient was dosed in a Phase 1/1b clinical trial of APVO436, a novel anti-CD123 by anti-CD3 bispecific antibody, which is being developed for the treatment of patients with acute myeloid leukemia and high-grade myelodysplastic syndrome.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">Aptevo presented new data for APVO436 at the AACR 2018 Annual Meeting.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">Corvus announced updated clinical and biomarker data from its ongoing Phase 1/1b study of CPI-444 in patients with treatment-refractory renal cell carcinoma, which demonstrated an overall survival of 88% at more than 20 months follow-up with CPI-444 administered in combination with atezolizumab.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;padding-left:14.5pt;">Corvus announced the publication of results of preclinical studies of CPI-444 demonstrating that it induces dose-dependent antitumor responses as a monotherapy and in combination with anti-PD-1, anti-PD-L1 and anti-CTLA-4 therapies.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;padding-left:14.5pt;">On December 3, 2018, Amgen announced the first clinical results from a study evaluating investigational novel </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">BiTE immunotherapy AMG 330. In a Phase 1 dose-escalation study, AMG 330, which targets CD33, provided early evidence of tolerability and anti-tumor activity in patients with relapsed and/or refractory multiple myeloma and relapsed or refractory acute myeloid leukemia. </span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Seelos closed a reverse merger with Apricus Biosciences and is now publicly traded on the Nasdaq Capital Market under the trading symbol &#8220;SEEL&#8221;. In conjunction with the reverse merger transaction, Seelos raised gross proceeds of $18 m</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">illion in a private financing.</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">3</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">OmniAb-derived RVT-1401 (previously HL 161) have formed the foundation of a new company called Immunovant during 2018.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;padding-left:14.5pt;">Nucorion Pharmaceuticals presented preclinical data for its novel liver-targeting prodrug technology program, CO1010, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">for the treatment of hepatitis B at the European Association for the Study of the Liver&#8217;s International Liver Congress.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;padding-left:14.5pt;">Syros Pharmaceuticals announced new preclinical data on SY-1365, its first-in-class selective CDK7 inhibitor, showing that it inhibits tumor cell growth in HR-positive breast cancer cell lines that are resistant to treatment with CDK4/6 inhibitors and that it has synergistic activity in combination with fulvestrant in these treatment-resistant cells.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;padding-left:14.5pt;">OmniAb partner Arcus </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">announced that abstracts relating to its portfolio were presented at the Society for Immunotherapy of Cancer Annual Meeting.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Arcus </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">announced that the FDA cleared the IND application for OmniAb-derived AB122 and the company&#160;presented a poster on AB122 at the AACR 2018 Annual Meeting.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">Arcus </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">also announced a collaboration agreement with Infinity Pharmaceuticals to evaluate AB122 with IPI549, an immuno-oncology candidate that selectively inhibits PI3K-gamma.</span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">MEI Pharma announced a poster presentation related to ME-344 at the 2018 ASCO Annual</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"> Meeting.</span></div><div><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Internal Pipeline Highlights</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">We have continued to make progress on our Captisol-enabled (CE) iohexol program, including </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">deepening the preclinical dataset significantly, which is designed to further illustrate the differentiating features of our product. We are in final preparations for making our Clinical Trial Application submission to the health authorities in Canada where our first in-human trial will be run this year. We've manufactured our clinical batches of CE-iohexol and are expecting to initiate the clinical trial this quarter and we plan to have Phase 1 bioavailability data on CE-iohexol in the third quarter of 2019. </span></div><div style="text-indent:-18pt;padding-left:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">We now have five internal antibody-related programs that we initiated in 2018. The programs are focused on targets for which biology is known, centered in the oncology and inflammation therapy areas.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Technologies</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A variety of technology platforms that enable elements of drug discovery or development form the basis of our portfolio of fully-funded shots on goal. Platform technologies or individual drugs discovered by Ligand are related to a broad estate of intellectual property that includes over 1,200&#160;patents issued worldwide.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">OmniAb Technologies</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;line-height:120%;">O</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">ur OmniAb technology includes our OmniRat, OmniMouse, OmniFlic and OmniChicken technology platforms for use in discovering fully human antibodies. The OmniRat, OmniMouse, and OmniFlic platforms consist of genetically-engineered transgenic animals that produce a broadly diversified repertoire of antibodies and enable novel fully-human antibody drug discovery and development by our OmniAb partners. Fully-human OmniAb antibodies provide advantages to our partners in that fully-human antibodies have reduced immunogenicity, streamlined development timelines and costs, and accelerated novel antibody discovery. The OmniChicken platform consists of genetically-engineered transgenic chickens which enable the generation of novel antibodies against targets that are not immunogenic in mammals like mice and rats. Currently, more than 40 partners are utilizing OmniAb animals in their drug discovery and development efforts. We acquired these technologies through the acquisition of OMT in January 2016 and Crystal in October 2017.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Vernalis Design Platform (VDP)</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">The VDP technology leverages our leadership in structure-guided drug discovery in which protein structure, drug fragment screening and modeling are integrated&#160;with medicinal chemistry to enable the rapid discovery of novel drugs. The VDP approach establishes structural information via x-ray crystallography and NMR&#160;methods and develops reliable assay systems to test biophysical, functional and cellular properties. The VDP has proven success with highly-challenging pharmaceutical&#160;targets and has generated a broad portfolio, with over 5,000 novel drug/target complexes determined and over 400 granted and pending patents. We acquired the VDP&#160;technology through our acquisition of Vernalis in October of 2018, and maintain state-of-the-art laboratories in Cambridge, UK.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Captisol Technology</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Captisol is our patented, uniquely-modified cyclodextrin that is specifically designed to maximize safety, while improving the solubility, stability and bioavailability of APIs. Captisol can enable faster and more efficient development paths for our partners, given its known regulatory acceptance. We maintain both Type IV and Type V DMFs with the FDA.  These DMFs contain manufacturing and safety information relating to Captisol that our licensees can reference when developing</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">4</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Captisol-enabled drugs. We also filed a DMF in Japan in 2015. Captisol-enabled drugs are marketed in more than 60 countries, and over 40 partners have Captisol-enabled drugs in development.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">LTP Technology Platform</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The LTP Technology platform is a novel prodrug technology designed to selectively deliver a broad range of pharmaceutical agents to the liver. A prodrug is a biologically inactive compound that can be metabolized in the body to produce an active drug. The LTP Technology works by chemically modifying biologically active molecules into an inactive prodrug, which will be administered to a patient and later activated by specific enzymes in the liver. The technology can be used to improve the safety and/or activity of existing drugs, develop new agents to treat certain liver-related diseases, and treat diseases caused by imbalances of circulating molecules that are controlled by the liver. The technology is especially applicable to metabolic and cardiovascular indications, among others. Currently 3&#160;programs are utilizing the LTP Technology or related platform(s).</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">SUREtechnology Platform (owned by Selexis)</span></div><div><span><br/></span></div><div style="text-indent:26.64pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We acquired economic rights to over 30 SURE</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">technology</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Platform programs from Selexis in two separate transactions in 2013 and 2015, granting us rights to downstream economics on novel biologics and biosimilars programs. The SURE</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">technology</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Platform, developed and owned by Selexis, is a novel technology that improves the way that cells are utilized in the development and manufacturing of recombinant proteins and drugs. The technology is based on novel DNA-based elements that control the dynamic organization of chromatin within mammalian cells and allow for higher and more stable expression of recombinant proteins. The technology creates advantages over traditional approaches including accelerated development and manufacturing times, high yields and increased compound stability.</span></div><div><span><br/></span></div><div><span><br/></span></div><div style="margin-bottom:10pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">5</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Partners and Licensees</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We currently have partnerships and license agreements with over 110 pharmaceutical and biotechnology companies. In addition to the table below, we also have more than 10 undisclosed partners and licensees.</span></div><div style="margin-bottom:10pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:89.619883%;"><tr><td style="width:1.0%;"></td><td style="width:18.554649%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.419250%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.757586%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:18.554649%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.419250%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.920718%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:18.554649%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.419250%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Big Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ticker</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Generics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ticker&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Biotech, continued&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ticker&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AbbVie&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ABBV&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Alvogen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Immunovant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AstraZeneca&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AZN&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Avion&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">J-Pharma&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Baxter&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BAX&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BioCad&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Marinus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MRNS&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Boehringer Ingelheim&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Coherus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CHRS&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MEI&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MEIP&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BMS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BMY&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gedeon Richter&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GEDSF&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Melinta&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MLNT&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Daiichi Sankyo&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">DSKY&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Zydus Cadila&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CADILAHC&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Menarini&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Eli Lilly&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LLY&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Meridian Labs&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Eisai&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4523&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metavant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GSK&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GSK&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Biotech</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ticker</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merrimack&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MACK&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Janssen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">JNJ&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ABBA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novogen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NVGN&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merck&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MRK&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AiCuris&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Nucorion&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merck KGaA&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MRK&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aldeyra&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ALDX&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Opthea&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OPT&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novartis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NVS&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amgen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AMGN&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outlook&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OTLK&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ono&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4528&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Arcus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RCUS&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Otsuka&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4768&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ARMO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phoenix Tissue&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PFE&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Asahi Kasei&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3407&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Precision Biologics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sanofi&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SNY&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Azure&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RTRX&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Takeda&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4502&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">bluebird bio&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BLUE&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Revision Therapeutics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cantex&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SAGE&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SAGE&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Celgene&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CELG&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seattle Genetics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SGEN&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Specialty Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ticker</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corvus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CRVS&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SEEL&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Achaogen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AKAO&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">C-Stone&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2616.HK&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Servier&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aytu Bioscience&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AYTU&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CURx&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sunshine Lake&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aptevo&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">APVO&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Symphogen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Beloteca&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exelixis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EXEL&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teneobio&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CorMatrix&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Five Prime&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FRPX&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TG Therapeutics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TGTX&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CTI Biopharma&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CTIC&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">F-Star&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tizona&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cuda&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genmab&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GEN&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vaxxas&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ferring&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genagon&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vega&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gloria&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2437&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genekey Biotech&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VentiRx&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lundbeck&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LUN&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Glenmark&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GLENMARK&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Verona&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VRNA&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gilead Sciences&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GILD&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vertex&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VRTX&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sermonix&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HanAll&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9420&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VKTX&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shire&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SHPG&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Harbour&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Spectrum&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SPPI&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">iMetabolic&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XTL Bio&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XTLB&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teijin&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TINLF&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">WuXi&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vireo Health&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Upsher-Smith&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Private&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">6</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Portfolio</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have a large portfolio of current and future potential revenue-generating programs, including over 200&#160;fully-funded by our partners.  In addition to the table below, we also have more than 60 undisclosed programs.</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.152047%;"><tr><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:12pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Approved</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#345133;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Blood Disorders</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#99ccff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cardiovascular</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#008080;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CNS</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Promacta</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#99ccff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Baxter</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#99ccff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Nexterone </span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Lundbeck</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Carnexiv</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#99ccff;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exelixis/Daiichi-Sankyo</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#99ccff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Minnebro</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Menarini</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Frovatriptan</span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cancer</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#969696;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Medical Device/Cardiology</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Amgen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Kyprolis</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Zydus Cadila</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Vivitra</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#969696;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo Base Business</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#969696;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Spectrum</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Evomela</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Zydus Cadila</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Bryxta</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:4pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#993300;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Infectious Disease</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#ff6600;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inflammatory/Metabolic</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Alvogen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Voriconazole</span></td><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Aytu</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Tuzistra</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Biocad</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interferon beta-1a</span></td></tr><tr><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Melinta</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Baxdela</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viviant/Conbriza</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Hikma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Voriconazole</span></td><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Par Pharmaceuticals</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Posaconazole</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Duavee</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Merck</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Noxafil-IV</span></td><td colspan="3" style="background-color:#993300;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Pfizer</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Vfend-IV</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Zydus Cadila</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exemptia</span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:12pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 3 or Regulatory Submission Stage</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#345133;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Blood Disorders</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#bde782;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Severe and Rare</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#ff6600;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inflammatory/Metabolic</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Biocad</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">BCD-066</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sparsentan</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Coherus</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ff6600;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CHS-0214</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Bioverativ</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Sutimlimab</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cancer</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#008080;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CNS</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Oncobiologics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">ONS-3010</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Takeda</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Pevonedistat</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SAGE</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Brexanolone</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Oncobiologics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">ONS-1045</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Sedor</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CE-Fosphenytoin</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Sunshine Lake</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Vilazodone</span></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:8pt;background-color:#ffcc99;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other / Undisclosed</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#facb9d;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aldeyra Therapeutics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#facb9d;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Reproxalap</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:12pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 2</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#345133;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Blood Disorders</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#993300;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Infectious Disease</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#008080;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CNS</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">KLM465</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Gilead</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">GS-5734</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CurX</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">IV Topiramate</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Pradefovir</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Marinus Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Ganaxalone IV</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Seelos</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Aplindore</span></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:#008080;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:3pt;background-color:#008080;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cancer</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">C-Stone</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CS1001</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Eli Lilly</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Merestinib</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">J-Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">JPH-203</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cantex</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CX-01</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Eli Lilly</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Prexasertib</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Precision Biologics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">NPC-1C</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CTI Biopharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Tosedostat</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Gloria</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">GLS010</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">VentiRx Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">VTX-2337</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Sermonix</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Lasofoxifene</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#99ccff;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cardiovascular</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#ffcc99;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other / Undisclosed</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#bde782;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Severe and Rare</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#a0cefc;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cardioxyl / BMS</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#a0cefc;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">BMS986231</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Opthea Ltd</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OPT-302</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PTX-022</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" rowspan="2" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XTL Bio</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">hCDR1</span></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:9pt;background-color:#ff6600;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inflammatory and Metabolic</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:9pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Azure</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lasofoxifene</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Verona</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ensifentrine</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metavant</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RT-1502</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VK5211</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ECF843</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VK2809/VK0214</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Budesonide</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VK0612</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">7</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.152047%;"><tr><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:12pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 1</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cancer</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Amgen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">AMG-330</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">IBC Generium</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Deplera</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Servier</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">S55746/S64315</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Aptevo</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">APVO436</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Janssen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">JNJ64007957</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Symphogen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SYM022</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Arcus</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">AB122</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">MEI Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">ME-344</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Symphogen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SYM023</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Corvus</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CPI-444</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Meridian</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">ML-061</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Upsher-Smith</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CXCR4</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">F-Star</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">FS-102</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">MIK-665</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">VentiRx Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">VTX-1463</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Gedeon Richter</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Bevacizumab</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">BCL-201</span></td><td colspan="3" style="background-color:#003366;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">MB07133</span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#993300;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Infectious Disease</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#bde782;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Severe and Rare</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#ffcc99;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other / Undisclosed</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Vaxxas</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#913310;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Nanopatch</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IBC Generium</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GNR-008</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#facb9d;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phoenix Tissue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#facb9d;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PTR-01</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Takeda</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bde782;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TAK-925</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#f36624;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inflammatory and Metabolic</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gedeon Richter</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RGB-03</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HanAll/Harbour</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HL161</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" rowspan="2" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genekey Biotech</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PCSK-9</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Immunovant</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RVT-1401</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Takeda</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TAK-020</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.152047%;"><tr><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.731677%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.304348%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.459627%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:12pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pre-Clinical</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#ffcc99;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other / Undisclosed</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ABBA</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb </span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Electra</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb </span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ono Pharmaceuticals</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AbbVie</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb </span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">F-Star</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb </span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Achaogen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ferring</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Revision Therapeutics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CvZ001</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amgen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fred Hutchinson</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seattle Genetics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ARMO Biosciences</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genmab</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Symphogen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Avion</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE programs</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gilead</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-program</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teneobio</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Beloteca</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Ziprasidone</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Glenmark</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Teva</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Boehringer Ingelheim</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">HanAll</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tizona</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Celgene</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">iMetabolic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vega</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Celgene</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vipadenant</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Janssen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">VenBio</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Covagen</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">KSQ Therapeutics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Wuxi</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Five Prime</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merck KGaA</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb</span></td><td colspan="3" style="background-color:#ffcc99;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:#ffcc99;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="24" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#f36624;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inflammatory and Metabolic</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Meloxicam</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SLS-010</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vireo Health</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Cannabinoids</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SLS-008</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">DGAT-1 Inhibitor</span></td><td colspan="3" style="background-color:#f36624;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:#f36624;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#993300;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Infectious Disease</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#008080;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CNS</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Nucorion</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">NUC-101</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cuda</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cudafol</span></td><td colspan="3" style="background-color:#2c807f;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SAGE</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SAGE-689</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Nucorion</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#993300;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">NUC-202</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">CURx Pharma</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">IV Lamotrigine</span></td><td colspan="3" style="background-color:#2c807f;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Seelos</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#2c807f;text-align:center;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">SLS-012</span></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid ;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid ;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#003366;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Cancer</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#345133;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Blood Disorders</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:#969696;text-align:center;vertical-align:middle;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Medical Device/Cardiology</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Nucorion</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">NUC-404</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#345133;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">EPOR  Agonist</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#969696;text-align:center;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#2a2a2a;background-color:rgb(255,255,255, 0.0);">CorMatrix</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#969696;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#2a2a2a;background-color:rgb(255,255,255, 0.0);">CorMatrix Pipeline</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Oncobiologics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Rituximab</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">Oncobiologics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">ONS-1050</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">TG Therapeutics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#003366;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#ffffff;background-color:rgb(255,255,255, 0.0);">IRAK4</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">8</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Selected Commercial Programs</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have multiple programs under license with other companies that have products that are already being commercialized. The following programs represent components of our current portfolio of revenue-generating assets and potential for near-term growth in royalty and other revenue. For information about the royalties owed to us for these programs, see &#8220;Royalties&#8221; later in this business section.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Promacta (Novartis)</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">We are party to a license agreement with Novartis related to Promacta, which is an oral medicine that increases the number of platelets in the blood. Platelets are one of the three components of blood and facilitate clotting in the blood.  Individuals with low platelets can be at significant risk of bleeding or death. Because of the importance of having a sufficient number of platelets, Promacta has broad potential applicability to a number of medical situations where low platelets exist.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Promacta is currently approved for four indications: (1) the treatment of thrombocytopenia in adult and pediatric patients 1 year and older with ITP who have had an insufficient response to corticosteroids, immunoglobulins or splenectomy; (2) thrombocytopenia in patients with chronic hepatitis C to allow the initiation and maintenance of interferon-based therapy; (3) in combination with standard immunosuppressive therapy for the first-line treatment of adult and pediatric patients 2 years and older with SAA; and (4) patients with SAA who have had an insufficient response to immunosuppressive therapy. Promacta was initially approved in 2008, and the product has been generating royalty revenue for Ligand since 2009. Promacta is known as Revolade in the EU and other non-US markets.</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:12.619883%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:41.274854%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:2.824561%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:20.660819%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:12.619883%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:60pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">Novartis has been and continues to pursue globalization of the brand and currently markets Promacta in multiple countries for the approved indications. Specifically, Promacta is currently approved for ITP in more than 100 countries, for the Hepatitis C-related indication in more than 50 countries, and for post-immunosuppressive therapy SAA indication in more than 45 counties. Approval of Promacta in the U.S. for the first-line treatment of SAA was obtained in November of 2018.  </span></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" rowspan="6" style="padding-top:2px;padding-bottom:2px;height:27pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:125%;">Beyond the currently-approved indications, Novartis has also disclosed that is performing or supporting development activities to expand the brand into new indications, including as a counter measure for the hematopoietic effects of acute radiation syndrome (H-ARS), and has been granted FDA Breakthrough Therapy designation.  As of January 2019, there are 46 open clinical trials related to Promacta (listed as recruiting or open, and not yet recruiting) on the clinicaltrials.gov website.</span></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:27pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:2pt solid #000000;border-left:2pt solid #000000;padding-left:1pt;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Promacta (Novartis)</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:2pt solid #000000;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; $100 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:2pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.7%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:2pt solid #000000;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$100 to $200 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.6%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$200 to $400 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$400 million to $1.5 billion</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9.4%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt;$1.5 billion</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9.3%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:66pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:130%;">We are entitled to receive royalties related to Promacta during the life of the relevant patents or following patent expiry, at a reduced rate for ten years from the first commercial sale, whichever is longer, on a country-by-country basis. Novartis has listed a patent in the FDA&#8217;s Orange Book for Promacta with an expiration date in 2028, and absent early termination for bankruptcy or material breach, the term of the agreement expires upon expiration of the obligation to pay royalties. There are no remaining milestones to be paid under the agreement.</span></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr></table></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">9</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">Kyprolis (Amgen)</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Ligand supplies Captisol to Amgen for use with Kyprolis, and granted Amgen an exclusive product-specific license under our patent rights with respect to Captisol. Kyprolis is formulated with Ligand&#8217;s Captisol technology and is approved in the United States for the following:</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">In combination with dexamethasone or combination with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy.</span></div><div style="text-indent:-18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;padding-left:14.5pt;">As a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy.</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.245614%;"><tr><td style="width:1.0%;"></td><td style="width:23.744048%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:23.744048%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.833333%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.494048%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:6.184524%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="9" rowspan="5" style="padding-top:2px;padding-bottom:2px;height:14pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">Kyprolis is also approved in multiple countries outside the U.S. and Amgen continues to invest significantly in Kyprolis to further expand its label and geography. Amgen&#8217;s obligation to pay royalties does not expire until four years after the expiration of the last-to-expire patent covering Captisol. Our patents and applications relating to the Captisol component of Kyprolis are not expected to expire until 2033. </span></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:14pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:2pt solid #000000;border-left:2pt solid #000000;padding-left:1pt;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Kyprolis (Amgen)</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:2pt solid #000000;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; $250 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:2pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-top:2pt solid #000000;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$250 to $500 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:middle;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$500 to $750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;border-bottom:2pt solid #000;border-left:2pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt;$750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-bottom:2pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.0%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:middle;border-bottom:2pt solid #000;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr></table></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our agreement with Amgen may be terminated by either party in the event of material breach or bankruptcy, or unilaterally by Amgen with prior written notice, subject to certain surviving obligations. Absent early termination, the agreement will terminate upon expiration of the obligation to pay royalties. Under this agreement, we are entitled to receive remaining milestones of up to $1 million, revenue from clinical and commercial Captisol material sales and royalties on annual net sales of Kyprolis.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Evomela (Spectrum and CASI)</span></div><div><span><br/></span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ligand supplies Captisol to Spectrum for use with Evomela, which is a Captisol-enabled melphalan IV formulation.  The FDA approved Evomela for use in two indications:</span></div><div style="text-indent:-18pt;padding-left:45pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">A high-dose conditioning treatment prior to ASCT in patients with multiple myeloma</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#160;</span></div><div style="text-indent:-18pt;padding-left:45pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">For the palliative treatment of patients with multiple myeloma for whom oral therapy is not appropriate</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.</span></div><div style="padding-left:45pt;"><span><br/></span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Evomela has been granted Orphan Designation by the FDA for use as a high-dose conditioning regimen for patients with multiple myeloma undergoing ASCT. The Evomela formulation avoids the use of propylene glycol, which has been reported to cause renal and cardiac side-effects that limit the ability to deliver higher quantities of therapeutic compounds. The use of the Captisol technology to reformulate melphalan is anticipated to allow for longer administration durations and slower infusion rates, potentially enabling clinicians to safely achieve a higher dose intensity of pre-transplant chemotherapy.</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the terms of the license agreement, we granted an exclusive license to Spectrum under our patent rights to Captisol relating to the product. We are eligible to receive over $50 million in potential milestone payments under this agreement and royalties on global net sales of the Captisol-enabled melphalan product. Spectrum&#8217;s obligation to pay royalties will expire at the end of the life of the relevant patents or when a competing product is launched, whichever is earlier, but in no event within ten years of the commercial launch. Our patents and applications relating to the Captisol component of melphalan are not expected to expire until 2033. Absent early termination, the agreement will terminate upon expiration of the obligation to pay royalties. The agreement may be terminated by either party for an uncured material breach or unilaterally by Spectrum by prior written notice.</span></div><div style="text-indent:27pt;margin-top:10pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Spectrum sub-licensed Evomela rights for Greater China to CASI in 2014.  In December 2018, CASI announced China marketing approval of Evomela and a plan to launch the drug in China in 2019.</span></div><div style="text-indent:27pt;margin-top:10pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 17, 2019, Spectrum announced that they entered into a definitive agreement to sell its portfolio of seven FDA-approved hematology/oncology products&#160;including Evomela to Arotech Biopharma L.L.C..</span></div><div><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Baxdela IV (Melinta)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Melinta&#8217;s Baxdela IV is a Captisol-enabled delafloxacin-IV that was approved by the FDA in June 2017 for the treatment of acute bacterial skin and skin structure infections. Delafloxacin is a novel hospital-focused fluoroquinolone antibiotic with activity against a variety of disease-causing bacteria-gram-positives, gram-negatives, atypicals and anaerobes, including quinolone-resistant MRSA. Under the terms of the agreement, we may be entitled to regulatory milestones, as well as a royalty on potential future sales by Melinta, and revenue from Captisol material sales. </span></div><div style="margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">10</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Nexterone (Baxter)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have a license agreement with Baxter, related to Baxter's Nexterone, a Captisol-enabled formulation of amiodarone, which is marketed in the United States and Canada. We supply Captisol to Baxter for use in accordance with the terms of the license agreement under a separate supply agreement. Under the terms of the license agreement we will continue to earn milestone payments, royalties, and revenue from Captisol material sales.  We are entitled to earn royalties on sales of Nexterone through early 2033.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Noxafil-IV (Merck)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have a supply agreement with Merck related to Merck&#8217;s NOXAFIL-IV, a Captisol-enabled formulation of posaconazole for IV use. NOXAFIL-IV is marketed in the United States, EU and Canada. We receive our commercial compensation for this program through the sale of Captisol, and we do not receive a royalty on this program.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Duavee or Duavive (bazedoxifene/conjugated estrogens) and Viviant/Conbriza (Pfizer)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Pfizer is marketing bazedoxifene under the brand names Viviant</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;line-height:120%;vertical-align:top;">&#160;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">and Conbriza in various territories for the treatment of postmenopausal osteoporosis. Pfizer is responsible for the marketing of bazedoxifene, a synthetic drug specifically designed to reduce the risk of osteoporotic fractures while also protecting uterine tissue. Pfizer has combined bazedoxifene with the active ingredient in Premarin to create a combination therapy for the treatment of post-menopausal symptoms in women. Pfizer is marketing the combination treatment under the brand names Duavee and Duavive in various territories. Net royalties on annual net sales of Viviant/Conbriza and Duavee/Duavive are each payable to us through the life of the relevant patents or ten years from the first commercial sale, whichever is longer, on a country by country basis.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Aziyo Portfolio (Aziyo)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We receive a share of revenue from the currently marketed Aziyo portfolio of commercial pericardial repair and CanGaroo&#174;&#160;Envelope ECM products. In addition, Ligand has the potential to receive a share of revenue and potential milestones from the currently marketed CanGaroo&#174;&#160;ECM Envelope for cardiac implantable electronic devices.&#160;Aziyo&#8217;s products are medical devices that are designed to permit the development and regrowth of human tissue.</span></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">Exemptia, Vivitra and Bryxta (Zydus Cadila)</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Zydus Cadila&#8217;s Exemptia (adalimumab biosimilar) is marketed in India for autoimmune diseases. Zydus Cadila uses the Selexis technology platform for Exemptia. We are entitled to earn royalties on sales by Zydus Cadila for ten years following the first commercial sale.</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Zydus Cadila&#8217;s Vivitra (trastuzumab biosimilar) is marketed in India for breast cancer. Zydus Cadila uses the Selexis technology platform for Vivitra. We are entitled to earn royalties on sales by Zydus Cadila for ten years following the first commercial sale.</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Zydus Cadila&#8217;s Bryxta (bevacizumab biosimilar) is marketed in India for non-small cell lung cancer. Zydus Cadila uses the Selexis technology platform for Bryxta. We are entitled to earn royalties on sales by Zydus Cadila for ten years following the first commercial sale.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">Minnebro&#160;(Exelixis)</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Daiichi Sankyo announced on January 8, 2019 the receipt of marketing approval in Japan for MINNEBRO</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;line-height:115%;vertical-align:top;">&#160;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Tablets (esaxerenone) for the treatment of hypertension. Our partner, Exelixis, entered into a collaboration agreement with Daiichi Sankyo for the development of esaxerenone, a mineralocorticoid receptor antagonist. Under the terms of the agreement with Exelixis, we are entitled to receive a royalty on future sales.</span></div><div style="text-indent:36pt;margin-bottom:10pt;"><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Summary of Selected Development Stage Programs</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have multiple fully-funded partnered programs that are either in or nearing the regulatory approval process, or given the area of research or value of the license terms we consider particularly noteworthy. We are eligible to receive milestone payments and royalties on these programs. This list does not include all of our partnered programs. For information about the royalties owed to Ligand for these programs, see &#8220;Royalties&#8221; later in this business section. In the case of Captisol-related programs, we are also eligible to receive revenue for the sale of Captisol material supply.</span></div><div style="margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">11</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Zulresso-SAGE-547 (SAGE)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, SAGE, is developing novel medicines to treat life altering central nervous system disorders. SAGE filed an NDA with the FDA in 2018, seeking approval to market and sell Zulresso for the treatment of postpartum depression, or PPD. The NDA is currently under FDA review with a PDUFA date of March 19, 2019. We have the potential to receive milestone payments, royalties and revenue from Captisol material sales for Captisol-enabled programs. SAGE is responsible for all development costs related to the program.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">Sparsentan (Retrophin) </span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Retrophin, is developing sparsentan for orphan indications of severe kidney diseases, and has initiated a global pivotal Phase 3 clinical trial to enable an NDA filing for sparsentan for the treatment of FSGS. Additionally, Retrophin initiated a global pivotal Phase 3 clinical trial evaluating the long-term nephroprotective potential of sparsentan for the treatment of IgA nephropathy, a rare, immune complex mediated chronic glomerular disease.&#160;Certain patient groups with severely compromised renal function, including those with FSGS and IgA nephropathy, exhibit extreme proteinuria resulting in progression to dialysis and a high mortality rate. Sparsentan, with its unique dual blockade of angiotensin and endothelin receptors, is expected to provide meaningful clinical benefits in mitigating proteinuria in indications where there are no approved therapies.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under our license agreement with Retrophin, we are entitled to receive potential net milestones of over $70 million and net royalties on future worldwide sales by Retrophin. The royalty term is expected to be 10 years following the first commercial sale. Retrophin is responsible for all development costs related to the program.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Prexasertib- LY2606368 (Eli Lilly) </span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Eli Lilly is conducting Phase 2 clinical trials for prexasertib (Captisol-enabled LY2606368), a checkpoint kinase 1/2, or Chk 1/2, inhibitor for the treatment of solid tumors. Under the terms of the agreement, we may be entitled to regulatory milestones, royalties on potential future sales by Eli Lilly and revenue from Captisol material sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:113%;">BMS-986231 (formerly CXL-1427) (BMS)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, BMS, is conducting Phase 2 clinical trials for a Captisol-enabled second-generation prodrug that chemically breaks down to produce HNO and an inactive byproduct. HNO is thought to have a dual mode of action, by improving cardiac function and acting as a vasodilator for treating ADHF. Under the terms of the agreement, we may be entitled to development and regulatory milestones, and royalties on potential future sales by BMS and revenue from Captisol material sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:112%;">RVT-1502 (formerly LGD-6972) (Metavant)</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Metavant, an affiliate of Roivant, is developing RVT-1502, a GRA, which we licensed to Roivant in March 2018. In September 2017, we announced positive results from a Phase 2 clinical study evaluating the efficacy and safety of the compound (formerly known as LGD-6972), as an adjunct to diet and exercise, in subjects with type 2 diabetes mellitis inadequately controlled on metformin monotherapy. Roivant formed Metavant to pursue the development of RVT-1502 and other treatments for cardiometabolic diseases. We are entitled to potential development and regulatory milestones and royalties on potential future sales.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:112%;">RVT-1401/HL161 (Immunovant, HanAll and Harbour)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, HanAll has granted Immunovant an exclusive license for the development, manufacture and marketing of RVT-1401 (HL161, an anti-FcRn antibody) for the treatment of pathogenic IgG-mediated autoimmune diseases in the U.S., Canada, Mexico, the EU, the United Kingdom, Switzerland, Latin America, the Middle East and North Africa. Immunovant is currently conducting a Phase 1 clinical trial in healthy volunteers with plans to initiate Phase 2 studies in early 2019 in myasthenia gravis and other inflammatory diseases. Additionally, HanAll and Harbour BioMed, are collaborating to develop HL161 for similar treatment in China and Korea. HanAll retains the rights to HL161 in Korea and Harbour will control the marketing in China. As part of our agreement with HanAll, we are entitled to development and regulatory milestones and royalties on potential future sales from HanAll and sublicense revenues from Immunovant and Harbour based on amounts received by HanAll.</span></div><div style="margin-bottom:6pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">12</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">TR-Beta - VK2809 and VK0214 (Viking) </span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:61.888889%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.391813%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.719298%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;height:32pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">Viking is developing VK2809, a novel selective TR-Beta agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia and NASH. Viking announced positive results from its Phase 2 trial for VK2809 in hypercholesterolemia and fatty liver disease. Viking has also been granted orphan drug status by the FDA for the development of VK0214 for treatment of X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375 million of development, regulatory and commercial milestones and tiered royalties on potential future sales.&#160;Our TR Beta programs partnered with Viking are subject to CVR sharing and a portion of the cash received will be paid out to CVR holders.</span></div></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:32pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:2pt solid #000;border-left:2pt solid #000000;padding-left:1pt;border-right:2pt solid #000;padding-right:1pt;"><div style="text-align:center;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#ff6600;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">TR-Beta - VK2809 and VK0214</span><span style="background-color:rgb(255,255,255, 0.0);color:#ff6600;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;"> (Viking)</span></div></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:2pt solid #000;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; $500 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:2pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-top:2pt solid #000;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$500 to $750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:middle;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-bottom:2pt solid #000;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt;$750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-bottom:2pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-bottom:2pt solid #000;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr></table></div><div style="text-indent:22.5pt;margin-bottom:6pt;"><span><br/></span></div><div style="margin-bottom:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">SARM - VK5211 (Viking) </span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:64.666667%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.444444%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:11.888889%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;height:32pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:115%;">Our partner, Viking, is developing VK5211, a novel, potentially best-in-class SARM for patients recovering from hip-fracture. SARMs retain the beneficial properties of androgens without undesired side-effects of steroids or other less selective androgens. Viking announced positive results from its Phase 2 trial in patients who suffered hip fracture in the fourth quarter of 2017. Under the terms of the agreement with Viking, we may be entitled to up to $270 million of development, regulatory and commercial milestones as well as tiered royalties on potential future sales.</span></div></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:32pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:2pt solid #000000;border-left:2pt solid #000000;padding-left:1pt;border-right:2pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">SARM - VK5211 (Viking)</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:2pt solid #000;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; $500 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-top:2pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.25%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-top:2pt solid #000;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$500 to $750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.25%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:middle;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-bottom:2pt solid #000;border-left:2pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt;$750 million</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:middle;border-bottom:2pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9.25%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:middle;border-bottom:2pt solid #000;border-right:2pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr></table></div><div style="text-indent:22.5pt;"><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Lasofoxifene (Sermonix and Azure) </span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Lasofoxifene is a selective estrogen receptor modulator for osteoporosis treatment and other diseases, discovered through the research collaboration between us and Pfizer. Under the terms of the license agreement with Azure, we retained the rights to the oral formulation of lasofoxifene originally developed by Pfizer.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our partner, Sermonix has a license for the development of oral lasofoxifene for the United States and additional territories. Under the terms of the agreement, we are entitled to receive over $45 million in potential regulatory and commercial milestone payments as well as royalties on future net sales.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our partner Azure is developing a novel formulation of lasofoxifene targeting an underserved market in women&#8217;s health. Under the terms of our agreement with Azure, we are entitled to receive up to $2.6 million in potential development and regulatory milestones as well as royalties on future net sales through the later of the life of the relevant patents (currently expected to be at least until 2027) or 10 years after regulatory approval. Azure may terminate the license agreement at any time upon six months&#8217; prior notice.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Merestinib- LY2801653 (Eli Lilly) </span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Eli Lilly is conducting Phase 2 clinical trials for Captisol-enabled merestinib (formerly known as&#160;LY2801653),&#160;a c-Met inhibitor for treatment of cancer. Under the terms of the agreement, we may be entitled to regulatory milestones, royalties on potential future sales by Eli Lilly and revenue from Captisol material sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Pevonedistat - TAK-924 (Millennium/Takeda) </span></div><div style="text-indent:22pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our partner, Millennium/Takeda is currently conducting Phase 3 trials for the development of pevonedistat for the treatment of hematological malignancies and solid tumors. Pevonedistat is a Captisol-enabled Nedd8-Activating Enzyme Inhibitor. Under the terms of the clinical-stage agreement, we may be entitled to development milestones from Millennium/Takeda and revenue from Captisol material sales.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">JNJ64007957 (Janssen</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-style:italic;font-weight:700;line-height:115%;">)</span></div><div><span><br/></span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Janssen, is developing JNJ64007957,&#160;a BCMAxCD3 bispecific antibody discovered in part with the OmniAb platform technology. Janssen is currently conducting a Phase I trial for cancer therapy. We are entitled to earn milestones based on the development of JNJ64007957.</span></div><div style="margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">13</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">AMG-330 (Amgen)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our&#160;licensee, Amgen, is developing AMG 330, a bispecific T-cell engager (BiTE) antibody targeting CD33 and CD3, for use in humans for a wide variety of therapeutic indications. Under the terms of the agreement, we are entitled to milestones and royalties on future sales of AMG 330 formulated with Captisol.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Ganaxalone IV (Marinus)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Marinus, is conducting Phase 2 clinical trials with Captisol-enabled ganaxolone IV in patients with PPD&#160;and refractory status epilepticus. Marinus has exclusive worldwide rights to Captisol-enabled ganaxolone, a GABAA receptor modulator, for use in humans. We are entitled to development and regulatory milestones, royalties on potential future sales and revenue from Captisol material sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">APVO436 (Aptevo)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Aptevo, is currently conducting a Phase 1 trial of APVO436 for the treatment of acute myeloid leukemia.  There is a high unmet medical need for targeted immunotherapies such as APVO436, that can potentially treat patients with relapsed or refractory disease, or patients who cannot tolerate traditional chemotherapy. Under the terms of the agreement with Aptevo, we are entitled to milestones and royalties on future sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">WuXi Partnership</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">Pursuant to the WuXi Agreement, we have granted WuXi a non-exclusive license to use our OmniRat, OmniMouse and OmniFlic platforms solely to research, develop and make antibodies, and we have agreed to use commercially reasonable efforts to deliver to WuXi animals from such platforms on a purchase order basis to support WuXi&#8217;s licensing rights under the WuXi Agreement. Further, WuXi has the right to out-license antibodies it discovers (whether for itself or at the direction of out-licensees) under the WuXi Agreement to out-licensees worldwide. We are entitled to royalties in the low single digits on net sales of products. Unless earlier terminated, the term of the WuXi Agreement shall continue indefinitely. Either party may terminate the WuXi Agreement upon specified notice of the other party's uncured material breach of the WuXi Agreement. In addition, we have the right to terminate the WuXi Agreement if WuXi or one of its out-licensees challenges the validity of one of our patents covering the platform and WuXi has the right to terminate the WuXi Agreement for convenience following a specified period after notice of termination.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">In addition to other earlier stage programs, the following programs have been licensed pursuant to the WuXi Agreement: </span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:114%;">AB122/GLS010 (Arcus and Gloria)</span></div><div style="text-indent:27pt;padding-left:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">Our partner, WuXi, has outlicensed the rights to certain programs using the OmniAb technology to Arcus and Gloria.  Arcus, is currently conducting a Phase 1 trial to evaluate the safety and tolerability of AB122 in subjects with advanced solid tumors. Additionally, Gloria, is conducting a Phase 2 trial in China to evaluate the efficacy and safety of GLS-010 injection in the treatment of recurrent or refractory classical Hodgkin&#8217;s lymphoma. Under the terms of our agreement with WuXi, we are entitled to royalties on potential future sales.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:114%;">CS1001 (C-Stone)</span></div><div style="text-indent:27pt;padding-left:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:114%;">Our partner, WuXi, has outlicensed the rights to certain programs using the OmniAb technology to C-Stone. C-Stone, is currently conducting a Phase 2 trial to evaluate the efficacy and safety of CS1001 to treat patients with natural killer cell/T-cell lymphoma and classical Hodgkin&#8217;s lymphoma. Under the terms of our agreement with WuXi, we are entitled to royalties on potential future sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:114%;">CPI-444 (Corvus)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Corvus, is currently conducting a Phase 1b/2 clinical trial in patients with renal cell carcinoma to evaluate CPI-444, an antagonist of adenosine A2A, in combination with the immunotherapy drug atezolizumab. CPI-444 is also being evaluated in a Phase 1b/2 trial in combination with atezolizumab in patients with non-small cell lung cancer who have failed no more than two prior regimens. Under the terms of our agreement with Corvus, we are entitled to development and regulatory milestones and tiered royalties on potential future sales. The aggregate potential milestone payments from Corvus are&#160;approximately $220 million for all indications.</span></div><div style="margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">14</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:112%;">Ensifentrine &#8211; RPL554 (Verona)</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our partner, Verona, is currently conducting a comprehensive Phase 2 clinical trial for the development of ensifentrine as a maintenance treatment of COPD with nebulized and inhaled formulations. Verona has also completed a positive Phase 2a study evaluating ensifentrine as a treatment for cystic fibrosis. Under the terms of our agreement with Verona, we are entitled to development and regulatory milestones, including a&#160;&#163;5.0 million&#160;payment upon the first approval of any regulatory authority, and royalties on potential future sales.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:112%;">ECF843 (Novartis)</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Novartis is developing ECF843 for the treatment of dry-eye and other ophthalmic indications. ECF843 has been tested in a Phase 2 trial demonstrating the primary endpoint was met. Novartis uses the Selexis technology platform for ECF843. Under the terms of our agreement with Novartis, we are entitled to development and regulatory milestones and royalties on potential future sales.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Royalties</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have multiple programs under license with other companies that have products that are already being commercialized. In addition to the table below, we have generally described a typical Captisol and OmniAb royalty arrangement as low- to mid-single digit royalties. The following table represents substantially all of the disclosed information about our royalty arrangements:</span></div><div style="text-align:center;margin-bottom:10pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Royalty Table</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.298246%;"><tr><td style="width:1.0%;"></td><td style="width:27.922481%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:28.077519%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:38.000000%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:22pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#333399;background-color:rgb(255,255,255, 0.0);">Ligand Licenses With Tiered Royalties*&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Program&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Licensee&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Royalty Rate&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Duavee&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.5% - 2.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viviant/Conbriza&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pfizer&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.5% - 2.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Lamotrigine&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CURx&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.0% - 7.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Topiramate&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CURx&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.0% - 7.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Budesonide&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.0% - 10.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Meloxicam&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.0% - 10.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">IRAK4&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TG Therapeutics&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.0% - 9.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lasofoxifene&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sermonix&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.0% - 10.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FBPase Inhibitor (VK0612)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.5% - 9.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SARM (VK5211)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.25% - 9.25%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TR Beta (VK2809 and VK0214)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.5% - 7.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oral EPO&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.5% - 8.5%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">DGAT-1&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.0% - 7.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Various&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Nucorion&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.0% - 9.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Various&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.0% - 10.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb-iMetabolic&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">iMetabolic&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt;6%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb-Genagon&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genagon&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.0% - 6.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Mineral Coated Microparticle technology&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dianomi&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0% - 3.0%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PTX-022&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.0% - 9.8%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RVT-1502&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metavant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low double digit to mid-teen royalty&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CPI-444&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corvus&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Mid single digit to low-teen royalty&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ensifentrine (RPL554)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Verona&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low to mid-single digit royalty&#160;</span></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">15</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.298246%;"><tr><td style="width:1.0%;"></td><td style="width:27.922481%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:28.077519%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:38.000000%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:22pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#333399;background-color:rgb(255,255,255, 0.0);">Ligand Licenses With Fixed Royalties*</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Program</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Licensee</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#ff6600;background-color:rgb(255,255,255, 0.0);">Royalty Rate</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Evomela</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Spectrum Pharma</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Baxdela</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Melinta</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Brexalalone (SAGE-547)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">SAGE</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sparsentan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Fosphenytoin</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sedor</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pradefovir</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MB07133</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">KLM465</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Novartis</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14.5% (6.5% in year one)&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Topical lasofoxifene</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Azure Biotech</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MM-121</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merrimack Pharma</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt;1.0%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MM-141</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Merrimack Pharma</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt;1.0%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ME-143</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MEI Pharma</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ME-344</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MEI Pharma</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Reproxalap</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aldeyra Therapeutics</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">PCSK-9</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Genekey</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CS1001</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">C-Stone</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Various</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gloria</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4-1BB</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Zhilkang Hongyi</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">AB122</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Arcus</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Low single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb-KSQ Therapeutics</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">KSQ Therapeutics</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Single digit royalty&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-bottom:1pt solid #000;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-style:italic;line-height:120%;">*Royalty rates are shown net of sublicense payments. Royalty tier references for specific rates notated in the table are for up to and including the dollar amount referenced. Higher tiers are only applicable for the dollar ranges specified in the table.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:174%;">Contract Payments&#160;(Milestones)</span></div><div style="text-indent:36pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Many of our programs under license with our partners&#160;will generate&#160;contract payments to us if our partners reach certain&#160;development, regulatory and commercial milestones. The following table represents the potential maximum value of our contract payment pipeline on milestones by development stage, technology and partner (in thousands):</span></div><div style="margin-bottom:12pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.152047%;"><tr><td style="width:1.0%;"></td><td style="width:13.527950%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.527950%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.576398%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:13.527950%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.527950%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.042236%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:13.527950%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.341615%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Technology*&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Stage*&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner*&#160;</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $825,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $40,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Viking&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$1,500,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Captisol&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $175,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Clinical&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $500,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metavant&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$528,750&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $250,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Regulatory&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $1,000,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Janssen&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$245,400&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LTP/Hep Direct&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $250,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Commercial&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $1,660,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seelos&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$141,800&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NCE/Other&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $2,000,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $300,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$100,750&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $3,500,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $3,500,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corvus (Oncology)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$91,500&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Xi'an Xintong&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$43,125&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $848,675&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&gt; $3,500,000&#160;</span></td></tr></table></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-style:italic;line-height:120%;">*All tables exclude our annual access fees and collaboration revenue for development work.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:174%;">Internal Development Programs&#160;</span></div><div style="text-indent:22pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have a number of internal development programs focused on a wide-range of indications. Our primary research and development efforts are led by our teams in Emeryville, California and Cambridge, England. The following table represents internal programs eligible for further development or partnership:</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">16</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:14pt;margin-bottom:17pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:89.619883%;"><tr><td style="width:1.0%;"></td><td style="width:43.187602%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.452529%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:19.044046%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.778793%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:30.137031%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Program&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Development Stage&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indication&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Luminespib/Hsp90 Inhibitor</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 2</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oncology</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FAAH Inhibitor</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 1</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pain</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Sertraline, Oral Concentrate</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 1</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Depression</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Iohexol</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Phase 1</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diagnostics</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CCR1 Antagonist</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oncology</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Busulfan</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oncology</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Cetirizine Injection</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Allergy</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CE-Silymarin for Topical formulation</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sun damage</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">FLT3 Kinase Inhibitors</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oncology</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">GCSF Receptor Agonist</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Blood disorders</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liver Specific Glucokinase Activator</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diabetes</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Omnichicken derived antibodies (5 programs)</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Discovery</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Multiple</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;border-left:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Chk1 Inhibitor</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Preclinical</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;border-right:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Oncology</span></td></tr></table></div><div style="margin-top:17pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Manufacturing</span></div><div style="text-indent:24pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We contract with a third party manufacturer, Hovione, for Captisol production.&#160;Hovione is a global supplier with over 50 years of experience in the development and manufacture of APIs and Drug Product Intermediates. Hovione operates FDA-inspected sites in the United States, Macau, Ireland and Portugal.&#160;Manufacturing operations for Captisol are currently performed at two sites, in both of Hovione's Portugal and Ireland facilities with distribution operations also performed from Hovione's Portugal and Ireland sites. Additionally, we also store and distribute Captisol from a subterranean warehouse controlled by us and located in Kansas.&#160;We believe we maintain adequate inventory of Captisol to meet our current and future partner needs.</span></div><div style="text-indent:27pt;margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In the event of a Captisol supply interruption, we are permitted to designate and, with Hovione&#8217;s assistance, qualify one or more alternate suppliers.&#160;If the supply interruption continues beyond a designated period, we may terminate the agreement.&#160;In addition, if Hovione cannot supply our requirements of Captisol due to an uncured force majeure event, we may also obtain Captisol from a third party and have previously identified such parties.</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The current term of the agreement with Hovione is through December 2024. The agreement will automatically renew for successive two year renewal terms unless either party gives written notice of its intention to terminate the agreement no less than two years prior to the expiration of the initial term or renewal term. In addition, either party may terminate the agreement for the uncured material breach or bankruptcy of the other party or an extended force majeure event. We may terminate the agreement for extended supply interruption, regulatory action related to Captisol or other specified events. We have ongoing minimum purchase commitments under the agreement.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">For further discussion of these items, see below under </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#8220;Item 7. Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations.&#8221;</span></div><div style="margin-top:14pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Competition</span></div><div style="text-indent:24pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Some of the drugs we and our licensees and partners are developing may compete with existing therapies or other drugs in development by other companies. Furthermore, academic institutions, government agencies and other public and private organizations conducting research may seek patent protection with respect to potentially competing products or technologies and may establish collaborative arrangements with our competitors.</span></div><div style="text-indent:24pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our Captisol business may face competition from other suppliers of similar cyclodextrin excipients or other technologies that are aimed to increase solubility or stability of APIs. Our OmniAb antibody technology faces competition from suppliers of other transgenic animal systems that are also available for antibody drug discovery.</span></div><div style="text-indent:24pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our competitive position also depends upon our ability to obtain patent protection or otherwise develop proprietary products or processes. For a discussion of the risks associated with competition, see below under </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#8220;Item 1A. Risk Factors.&#8221;</span></div><div style="margin-top:14pt;margin-bottom:10pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">17</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:14pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Government Regulation</span></div><div style="text-indent:24pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The research and development, manufacturing and marketing of pharmaceutical products are subject to regulation by numerous governmental authorities in the United States and other countries.&#160;We and our partners, depending on specific activities performed, are subject to these regulations. In the United States, pharmaceuticals are subject to regulation by both federal and various state authorities, including the FDA. The Federal Food, Drug and Cosmetic Act and the Public Health Service Act govern the testing, manufacture, safety, efficacy, labeling, storage, record keeping, approval, advertising and promotion of pharmaceutical&#160;products and there are often comparable regulations that apply at the state level.&#160;There are similar regulations in other countries as well. For both currently marketed and products in development, failure to comply with applicable regulatory requirements can, among other things, result in delays, the suspension of regulatory approvals, as well as possible civil and criminal sanctions. In addition, changes in existing regulations could have a material adverse effect on us or our partners. For a discussion of the risks associated with government regulations, see below under &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 1A. Risk Factors.&#8221;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Patents and Proprietary Rights</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We believe that patents and other proprietary rights are important to our business. Our policy is to file patent applications to protect technology, inventions and improvements to our inventions that are considered important to the development of our business. We also rely upon trade secrets, know-how, continuing technological innovations and licensing opportunities to develop and maintain our competitive position.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Patents are issued or pending for the following key products or product families. The scope and type of patent protection provided by each patent family is defined by the claims in the various patents. The nominal patent expiration dates have been provided. The actual patent term may vary by jurisdiction and depend on a number of factors including potential patent term adjustments, patent term extensions, and terminal disclaimers. For each product or product family, the patents and/or applications referred to are in force in at least the United States, and for most products and product families, the patents and/or applications are also in force in European jurisdictions, Japan and other jurisdictions.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Promacta</span></div><div><span><br/></span></div><div style="text-indent:27pt;margin-bottom:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Patents covering Promacta are owned by Novartis. The United States patent listed in the FDA&#8217;s Orange Book relating to Promacta with the latest expiration date is not expected to expire until 2027. Six months of additional exclusivity to each of the U.S. expiration dates listed in the table has been granted due to pediatric studies conducted by GlaxoSmithKline plc (NYSE:GSK), thereby taking the latest expiration date into 2028. The type of patent protection (</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">e.g</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">., composition of matter or use) and the expiration date for each unexpired patent listed in the Orange Book are provided in the following table. In addition, certain related patents in the commercially important jurisdictions of Europe and Japan are identified in the following table.</span></div><div style="text-indent:27pt;margin-bottom:6pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"><tr><td style="width:1.0%;"></td><td style="width:14.329705%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.485226%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="18" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Promacta&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United States&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corresponding Foreign&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Type of Protection&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Patent No.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Expiration Date&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Patent Number&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expiration Date&#8225;&#160;</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,160,870&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11/20/2022&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,864,981&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,889,838&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,294,378&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/14/2025*&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,813,875&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,546,919&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,332,481&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,294,378&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/14/2025*&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,864,981&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,889,838&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,813,875&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,546,919&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,452,874&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,864,981&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,889,838&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,813,875&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,546,919&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">18</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"><tr><td style="width:1.0%;"></td><td style="width:14.329705%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.485226%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.796267%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,473,686&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,864,981&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,294,378&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/14/2025*&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,889,838&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,813,875&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,546,919&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,547,719&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7/13/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,534,390&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/21/2023&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,612,414&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/21/2023&#160;</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,790,704&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,294,378&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/14/2025*&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,864,981&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,889,838&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,813,875&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,546,919&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/24/2021&#160;</span></td></tr><tr><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,795,293&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/21/2023&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,534,390&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/21/2023&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,612,414&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/21/2023&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,052,993&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,052,994&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,052,995&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,062,665&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,071,129&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,828,430&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,237&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:115%;">8/1/2027&#8273;</span></div></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,419,866&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,735,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,144,713&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/1/2027&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:5.2pt;font-weight:700;line-height:120%;vertical-align:top;">&#8225;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Expiration dates of European and Japanese patents are calculated as 20 years from the earliest nonprovisional filing date to which priority is claimed, and may not take into account extensions that are or may be available in these jurisdictions.</span></div><div style="margin-bottom:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8270;Includes extension of term through Supplementary Protection Certificate (SPC)</span></div><div style="margin-bottom:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8273;Revoked; on appeal</span></div><div><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Kyprolis</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Patents protecting Kyprolis include those owned by Amgen and those owned by us. The United States patent listed in the Orange Book relating to Kyprolis with the latest expiration date is not expected to expire until 2029. Patents and applications owned by Ligand relating to the Captisol component of Kyprolis are not expected to expire until 2033. Amgen has filed suit against several generic drug companies over their applications to make generic versions of Kyprolis, with a trial scheduled for May 2019. The type of patent protection (</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">e.g</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">., composition of matter or use) for each patent listed in the Orange Book and the expiration dates for each patent listed in the Orange Book are provided in the following table.  In addition, certain related patents in the commercially important jurisdictions of Europe and Japan are identified in the following table.</span></div><div style="text-indent:27pt;margin-bottom:6pt;"><span><br/></span></div><div style="text-indent:27pt;margin-bottom:6pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">19</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.883041%;"><tr><td style="width:1.0%;"></td><td style="width:14.332820%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.640986%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.795069%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.795069%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.640986%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.795069%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="18" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Kyprolis&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United States&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corresponding Foreign&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Type of Protection&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Patent No.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Expiration Date&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Patent Number&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expiration Date&#8225;&#160;</span></td></tr><tr><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,232,818&#160;</span></td><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,781,688&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,266,999&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,270,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,101,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,743,720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="6" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" rowspan="6" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,417,042&#160;</span></td><td colspan="3" rowspan="6" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7/20/2026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,781,688&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,266,999&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,270,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,101,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,743,720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,491,704&#160;</span></td><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,781,688&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,266,999&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,270,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,101,026&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,743,720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,737,112&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/7/2027&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,819,353&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/7/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,260,835&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/7/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,261,236&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/7/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,990,155&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/7/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,108,509&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/9/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,129,346&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,616,569&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,207,125&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,781,688&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,616,569&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,743,720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/8/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,207,126&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,616,569&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,207,127&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,616,569&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,207,297&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,745,064&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,394,423&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,616,569&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/14/2025&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,493,582&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2/27/2023</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A&#160;</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,511,109&#160;</span></td><td colspan="3" rowspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/21/2029&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,796,134&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/21/2029&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,675,629&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/21/2029&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,081,964&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/21/2029&#160;</span></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="margin-bottom:12pt;"><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:5.2pt;font-weight:700;line-height:120%;vertical-align:top;">&#8225;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Expiration dates of European and Japanese patents are calculated as 20 years from the earliest nonprovisional filing date to which priority is claimed, and do not take into account extensions that are or may be available in these jurisdictions.</span></div><div style="margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">20</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Captisol</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Patents and pending patent applications covering Captisol are owned by us. Other patents and pending patent applications covering methods of making Captisol are owned by us or by Pfizer. The patents covering the Captisol product, if issued, with the latest expiration date would not be set to expire until 2033 (</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">see, e.g.,</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"> U.S. Patent No. 9,493,582 (expires Feb. 27, 2033)).&#160;We have asserted U.S. Patents 8,410,077, 9,200,088, and 9,493,582 against Teva in connection with their attempt to obtain FDA approval to manufacture and sell a generic version of EVOMELA&#174;.&#160;We also own several patents and pending patent applications covering drug products containing Captisol as a component. The type of patent protection (</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">e.g</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">., composition of matter or use) and the expiration dates for several issued patents covering Captisol are provided in the following table. In addition, certain related patents and applications in the commercially important jurisdictions of Europe and Japan are listed in the following table.</span></div><div style="text-indent:27pt;margin-bottom:6pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"></td><td style="width:14.408669%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:12.241486%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.195046%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="18" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Captisol</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United States</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corresponding Foreign&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Type of Protection</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Patent No.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Expiration Date</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Patent Number</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expiration Date&#8225;</span></td></tr><tr><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,114,438&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/19/2028</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,708,225&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/22/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,141,906&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/22/2025</span></td></tr><tr><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,117,940&#160;</span></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/22/2025</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,708,225&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/22/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,141,906&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/22/2025</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,629,331&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,945,228&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,335,707&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,581,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,465,432&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2026</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,049,003&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/19/2026</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,583,668&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,846,901&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,945,228&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,335,707&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,581,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,465,432&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2026</span></td></tr><tr><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,829,182&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,945,228&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,335,707&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,581,078&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,952,197&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,465,432&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2026</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use/MoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,617,352&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,952,197&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/26/2025</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM / Use</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,635,773&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,923,144&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,039,721&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,276,828&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,444,548&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,410,077&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,923,144&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,039,721&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,276,828&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,444,548&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,200,088&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,923,144&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,039,721&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,276,828&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,444,548&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-bottom:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">21</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"></td><td style="width:14.408669%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:12.241486%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.195046%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.718266%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,750,822&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,923,144&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,039,721&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,276,828&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,444,548&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,117,951&#160;</span></td><td colspan="3" rowspan="4" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/13/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,923,144&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,039,721&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,276,828&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,444,548&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/28/2029</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,751,957&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2/14/2033</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,493,582&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2/27/2033</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/MoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,040,872&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2/27/2033</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr></table></div><div style="margin-top:3pt;margin-bottom:10pt;"><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:120%;vertical-align:top;">&#8225;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Expiration date of European and Japanese patents are calculated as 20 years from the earliest nonprovisional filing date to which priority is claimed, and do not take into account extensions that are or may be available in these jurisdictions.</span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Subject to compliance with the terms of the respective agreements, our rights to receive royalty payments under our licenses with our exclusive licensors typically extend for the life of the patents covering such developments. For a discussion of the risks associated with patent and proprietary rights, see below under &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 1A. Risk Factors.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div style="margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">OmniAb&#160;</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our OmniAb&#174; therapeutic antibody platforms, including OmniRat&#174;, OmniMouse&#174; and OmniChicken&#8482;, produce naturally optimized, fully human antibodies in animals. We have received patent protection&#160;on OmniAb antibodies and methods  in 30 countries, including the United States, multiple countries throughout Europe, Japan and China (see selected cases listed in the table below) and have&#160;56 patent applications pending in 24 countries worldwide. The patents and applications owned by us are expected to expire between 2028 and 2034 and partners are able to use the OMT patented technology to generate novel antibodies, which may be entitled to additional patent protection.</span></div><div style="text-indent:22pt;margin-bottom:6pt;"><span><br/></span></div><div style="text-indent:22pt;margin-bottom:6pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:90.350877%;"><tr><td style="width:1.0%;"></td><td style="width:15.637540%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.181230%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.064725%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:11.106796%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.181230%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.828479%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="18" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United States&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corresponding Foreign&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Type of Protection&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Patent No.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Expiration Date&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Patent Number&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expiration Date&#8225;&#160;</span></td></tr><tr><td colspan="3" rowspan="7" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,703,485&#160;</span></td><td colspan="3" rowspan="5" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/10/2031</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,152,880&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,336,329&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,603,323&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,823,690&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,220,827&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,388,233&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,072,069&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,907,157&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/30/2028&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,475,859&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4/15/2034</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A&#160;</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">22</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:12pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:93.421053%;"><tr><td style="width:1.0%;"></td><td style="width:15.057903%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.649452%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:20.691706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.676056%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.649452%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.275430%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="18" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OmniAb in OmniChicken</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United States</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-left:1pt solid #000000;padding-left:1pt;border-right:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corresponding Foreign</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Type of Protection</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Patent No.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">U.S. Expiration Date</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Patent Number</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expiration Date&#8225;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,030,095&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/23/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Europe</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,271,657&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/2/2029</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">MoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,415,173&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/2/2029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,737,707&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3/2/2029</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,592,644&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/30/2030</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Japan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,756,802&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/11/2030</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,404,125&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/29/2030</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,549,538&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/11/2030</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,010,058&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/11/2030</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,172,334&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8/11/2030</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/MoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,865,462&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/8/2032</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Com/MoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,644,178&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1/7/2031</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,380,769&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/23/2032</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">EU</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,713,712&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/23/2032</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,809,642&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5/23/2032</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM/Use</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,394,372&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/16/2032</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CoM</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,982,062&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10/16/2032</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">N/A</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="margin-top:3pt;margin-bottom:10pt;"><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:120%;vertical-align:top;">&#8225;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">Expiration date of European and Japanese patents are calculated as 20 years from the earliest nonprovisional filing date to which priority is claimed, and do not take into account extensions that are or may be available in these jurisdictions.</span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Vernalis</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our acquisition of Vernalis in October 2018 provides us with a portfolio of more than 8 fully-funded shots on goal, including RPL554, a Phase 2, novel treatment for COPD, which is partnered with Verona Pharma; and CPI-444, a Phase 1 adenosine A2A receptor antagonist for treatment of solid tumors, which is partnered with Corvus Pharmaceuticals. Vernalis has a worldwide patent portfolio of over 350 granted patents and over 35 pending applications, spanning over 60 countries.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;line-height:115%;">&#160;&#160;</span></div><div style="margin-top:14pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Employees</span></div><div style="text-indent:27pt;margin-top:5pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of February 12, 2019, including our newly acquired Vernalis&#160;subsidiary, we have&#160;116&#160;full-time employees, of whom 87 are involved directly in scientific research and development activities.</span></div><div style="margin-top:14pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Investor Information</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Financial and other information about us is available on our website at www.ligand.com. We make available on our website copies of our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, current reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section&#160;13(a) or 15(d) of the Exchange Act as soon as reasonably practicable after we electronically file such material with, or furnish it to, the U.S. Securities and Exchange Commission, or SEC. In addition, we have previously filed registration statements and other documents with the SEC. Any document we file may be inspected, at the SEC&#8217;s public reference room at 100 F Street NE, Washington, DC 20549, or at the SEC&#8217;s internet address at www.sec.gov. These website addresses are not intended to function as hyperlinks, and the information contained in our website and in the SEC&#8217;s website is not intended to be a part of this filing. Information related to the operation of the SEC&#8217;s public reference room may be obtained by calling the SEC at 800-SEC-0330.</span></div><div id="i_0_65"></div><div><span><br/></span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:9.876833%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.123167%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ITEM&#160;1A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">RISK FACTORS</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">The following is a summary description of some of the many risks we face in our business. You should carefully review these risks in evaluating our business, including the businesses of our subsidiaries. You should also consider the other information described in this report. Additional risks not presently known to us or that we currently deem immaterial also may impair our business.</span></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">23</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Future revenue based on Promacta, Kyprolis and Evomela, as well as sales of our other products, may be lower than expected.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Novartis is obligated to pay us royalties on its sales of Promacta, and we receive revenue from Amgen based on both sales of Kyprolis and purchases of Captisol material for clinical and commercial uses.  These payments are expected to be a substantial portion of our ongoing revenues for some time.  In addition, we receive revenues based on sales of Evomela and other products.  Any setback that may occur with respect to any of our partners' products, and in particular Promacta or Kyprolis, could significantly impair our operating results and/or reduce our revenue and the market price of our stock.  Setbacks for the products could include problems with shipping, distribution, manufacturing, product safety, marketing, government regulation or reimbursement, licenses and approvals, intellectual property rights, competition with existing or new products and physician or patient acceptance of the products, as well as higher than expected total rebates, returns, discounts, or unfavorable exchange rates.  These products also are or may become subject to generic competition.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Future revenue from sales of Captisol material to our license partners may be lower than expected.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Revenues from sales of Captisol material to our collaborative partners represent a significant portion of our current revenues.  Any setback that may occur with respect to Captisol could significantly impair our operating results and/or reduce the market price of our stock.  Setbacks for Captisol could include problems with shipping, distribution, manufacturing, product safety, marketing, government regulation or reimbursement, licenses and approvals, intellectual property rights, competition with existing or new products and physician or patient acceptance of the products using Captisol.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">If products or product candidates incorporating Captisol material were to cause any unexpected adverse events, the perception of Captisol safety could be seriously harmed. If this were to occur, we may not be able to sell Captisol unless and until we are able to demonstrate that the adverse event was unrelated to Captisol, which we may not be able to do. Further, the FDA could require us to submit additional information for regulatory review or approval, including data from extensive safety testing or clinical testing of products using Captisol. This would be expensive and it may delay the marketing of Captisol-enabled products and receipt of revenue related to those products, which could significantly impair our operating results and/or reduce the market price of our stock.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We obtain Captisol from a sole source supplier, and if this supplier were to cease to be able, for any reason, to supply Captisol to us in the amounts we require, or decline to supply Captisol to us, we would be required to seek an alternative source, which could potentially take a considerable length of time and impact our revenue and customer relationships.  We maintain inventory of Captisol, which has a five year shelf life, at three geographically dispersed storage locations in the United States and Europe.&#160; If we were to encounter problems maintaining our inventory, such as natural disasters, at one or more of these locations, it could lead to supply interruptions.  While we believe we maintain adequate inventory of Captisol to meet our current and expected future partner needs, our estimates and projections for Captisol demand may be wrong and any supply interruptions could materially adversely impact our operating results.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We currently depend on our arrangements with our partners and licensees to sell products using our Captisol technology. These agreements generally provide that our partners may terminate the agreements at will.  If our partners discontinue sales of products using Captisol, fail to obtain regulatory approval for products using Captisol, fail to satisfy their obligations under their agreements with us, or choose to utilize a generic form of Captisol should it become available, or if we are unable to establish new licensing and marketing relationships, our financial results and growth prospects would be materially affected. Furthermore, we maintain significant accounts receivable balances with certain customers purchasing Captisol materials, which may result in the concentration of credit risk. We generally do not require any collateral from our customers to secure payment of these accounts receivable.  If any of our major customers were to default in the payment of their obligations to us, our business, operating results and cash flows could be adversely affected.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Further, under most of our Captisol outlicenses, the amount of royalties we receive will be reduced or will cease when the relevant patent expires. Our low-chloride patents and foreign equivalents are not expected to expire until 2033, our high purity patents and foreign equivalents, are not expected to expire until 2029 and our morphology patents and foreign equivalents, are not expected to expire until 2025, but the initially filed patents relating to Captisol expired starting in 2010 in the United States and in 2016 in most countries outside the United States.  If our other intellectual property rights are not sufficient to prevent a generic form of Captisol from coming to market and if in such case our partners choose to terminate their agreements with us, our Captisol revenue may decrease significantly.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">24</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Third party intellectual property may prevent us or our partners from developing our potential products; our and our partners&#8217; intellectual property may not prevent competition; and any intellectual property issues may be expensive and time consuming to resolve.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The manufacture, use or sale of our potential products or our licensees' products or potential products may infringe the patent rights of others.  If others obtain patents with conflicting claims, we may be required to obtain licenses to those patents or to develop or obtain alternative technology.  We may not be able to obtain any such licenses on acceptable terms, or at all.  Any failure to obtain such licenses could delay or prevent us from pursuing the development or commercialization of our potential products.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Generally, our success will depend on our ability and the ability of our partners to obtain and maintain patents and other intellectual property rights for our and their potential products.&#160; Our patent position is uncertain and involves complex legal and technical questions for which legal principles are unresolved.&#160; Even if we or our partners do obtain patents, such patents may not adequately protect the technology we own or have licensed.&#160; </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We permit our partners to list our patents that cover their branded products in the Orange Book. If a third party files an NDA or ANDA for a generic drug product that relies in whole or in part on studies contained in our partner&#8217;s NDA for their branded product, the third party will have the option to certify to the FDA that, in the opinion of that third party, the patents listed in the Orange Book for our partner&#8217;s branded product are invalid, unenforceable, or will not be infringed by the manufacture, use or sale of the third party&#8217;s generic drug product. A third party certification that a new product will not infringe Orange Book-listed patents, or that such patents are invalid, is called a paragraph IV patent certification. If the third party submits a paragraph IV patent certification to the FDA, a notice of the paragraph IV patent certification must be sent to the NDA owner and the owner of the patents that are subject to the paragraph IV patent certification notice once the third-party&#8217;s NDA or ANDA is accepted for filing by the FDA. A lawsuit may then be initiated to defend the patents identified in the notice. The filing of a patent infringement lawsuit within 45 days of the receipt of notice of a paragraph IV patent certification automatically prevents the FDA from approving the generic NDA or ANDA until the earlier of the expiration of a 30-month period, the expiration of the patents, the entry of a settlement order stating that the patents are invalid or not infringed, a decision in the infringement case that is favorable to the NDA or ANDA applicant, or such shorter or longer period as the court may order. If a patent infringement lawsuit is not initiated within the required 45-day period, the third-party&#8217;s NDA or ANDA will not be subject to the 30-month stay.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Several third-parties have challenged, and additional third parties may challenge, the patents covering our partner&#8217;s branded products, including Promacta, Kyprolis and Evomela, which could result in the invalidation or unenforceability of some or all of the relevant patent claims. We may from time to time become party to litigation or other proceedings as a result of Paragraph IV certifications. For example, in November 2017, CyDex, our wholly owned subsidiary, received a paragraph IV certification from Teva alleging that certain of our patents related to Captisol were invalid, unenforceable and/or will not be infringed by Teva&#8217;s ANDA related to Spectrum Pharmaceuticals&#8217; NDA for Evomela. On December 20, 2017, CyDex filed a complaint against Teva in the U.S. District Court for the District of Delaware, asserting that Teva&#8217;s ANDA would infringe our patents.&#160;On March 22, 2018, Teva filed an answer and counterclaims seeking declarations of non-infringement and invalidity as to each of the asserted patents and on April 12, 2018, CyDex filed an answer to Teva&#8217;s counterclaims. On July 24, 2018, the U.S. District Court entered a Scheduling Order, setting a hearing on Claim Construction for April 1, 2019, and a five to six day bench trial to begin on January 27, 2020. Fact discovery is proceeding.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">In addition, we cannot assure you that all of the potentially relevant prior art-information that was or is deemed available to a person of skill in the relevant art prior to the priority date of the claimed invention-relating to our and our partners&#8217; patents and patent applications has been found. If such prior art exists, it can invalidate a patent or prevent a patent from issuing from a pending patent application, and we or our partners may be subject to a third party pre-issuance submission of prior art to the United States Patent and Trademark Office. Even if patents do successfully issue and even if such patents cover our or our partner&#8217;s products or potential products, third parties may an initiate litigation or opposition, interference, re-examination, post-grant review, inter partes review, nullification or derivation action in court or before patent offices, or similar proceedings challenging the validity, enforceability or scope of such patents, which may result in the patent claims being narrowed or invalidated, may allow third parties to commercialize our or our partners&#8217; products and compete directly with us and our partners, without payment to us or our partners, or limit the duration of the patent protection of our and our partners&#8217; technology and products. For example, we are aware that a third party has requested a reexamination of U.S. Patent No. 8,703,485 related to OmniAb on the basis of certain prior art documents. If the United States Patent and Trademark Office grants the request, we will have an opportunity to respond, but we cannot assure you that this patent will be held to be valid.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Litigation or other proceedings to enforce or defend intellectual property rights are often very complex in nature, may be very expensive and time-consuming, may divert our management&#8217;s attention from our core business, and may result in unfavorable results that could adversely impact our ability to prevent third parties from competing with our partner&#8217;s products.</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">25</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Any adverse outcome of such litigation or other proceedings could result in one or more or our patents being held invalid or unenforceable, which could adversely affect our ability to successfully execute our business strategy and negatively impact our financial condition and results of operations. However, given the unpredictability inherent in litigation, we cannot predict or guarantee the outcome of these matters or any other litigation. Regardless of how these matters are ultimately resolved, these matters may be costly, time-consuming and distracting to our management, which could have a material adverse effect on our business.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In addition, periodic maintenance fees, renewal fees, annuity fees and various other governmental fees on patents and or applications will be due to the U.S. and various foreign patent offices at various points over the lifetime of our and our licensees&#8217; patents and/or applications. We have systems in place to remind us to pay these fees, and we rely on our outside patent annuity service to pay these fees when due. Additionally, the U.S. and various foreign patent offices require compliance with a number of procedural, documentary, fee payment and other similar provisions during the patent application process. We employ reputable law firms and other professionals to help us comply, and in many cases, an inadvertent lapse can be cured by payment of a late fee or by other means in accordance with rules applicable to the particular jurisdiction. However, there are situations in which noncompliance can result in abandonment or lapse of the patent or patent application, resulting in partial or</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">complete loss of patent rights in the relevant jurisdiction. If such an event were to occur, it could have a material adverse effect on our business.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Any conflicts with the patent rights of others could significantly reduce the coverage of our patents or limit our ability to obtain meaningful patent protection.  For example, our European patent related to Agglomerated forms of Captisol was limited during an opposition proceeding, and the rejection of our European patent application related to High Purity Captisol was upheld on appealed.  In addition, any determination that our patent rights are invalid may result in early termination of our agreements with our license partners and could adversely affect our ability to enter into new license agreements.  We also rely on unpatented trade secrets and know-how to protect and maintain our competitive position.  We require our employees, consultants, licensees and others to sign confidentiality agreements when they begin their relationship with us.  These agreements may be breached, and we may not have adequate remedies for any breach.  In addition, our competitors may independently discover our trade secrets.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We may also need to initiate litigation, which could be time-consuming and expensive, to enforce our proprietary rights or to determine the scope and validity of others' rights.  If this occurs, a court may find our patents or those of our licensors invalid or may find that we have infringed on a competitor's rights.  In addition, if any of our competitors have filed patent applications in the United States which claim technology we also have invented, the United States Patent and Trademark Office may require us to participate in expensive interference proceedings to determine who has the right to a patent for the technology.  </span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The occurrence of any of the foregoing problems could be time-consuming and expensive and could adversely affect our financial position, liquidity and results of operations.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">We rely heavily on licensee relationships, and any disputes or litigation with our partners or termination or breach of any of the related agreements could reduce the financial resources available to us, including milestone payments and future royalty revenues.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our existing collaborations may not continue or be successful, and we may be unable to enter into future collaborative arrangements to develop and commercialize our unpartnered assets.  Generally, our current collaborative partners also have the right to terminate their collaborations at will or under specified circumstances.  If any of our collaborative partners breach or terminate their agreements with us or otherwise fail to conduct their collaborative activities successfully (for example, by not making required payments when due, or at all), our product development under these agreements will be delayed or terminated.  Disputes or litigation may also arise with our collaborators (with us and/or with one or more third parties), including those over ownership rights to intellectual property, know-how or technologies developed with our collaborators.  For example, we are asserting our rights to receive payment against one of our collaborative partners which could harm our relationship with such partner.  Such disputes or litigation could adversely affect our rights to one or more of our product candidates and could delay, interrupt or terminate the collaborative research, development and commercialization of certain potential products, create uncertainty as to ownership rights of intellectual property, or could result in litigation or arbitration.  In addition, a significant downturn or deterioration in the business or financial condition of our collaborators or partners could result in a loss of expected revenue and our expected returns on investment.  The occurrence of any of these problems could be time-consuming and expensive and could adversely affect our business.</span></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">26</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our product candidates, and the product candidates of our partners, face significant development and regulatory hurdles prior to partnering and/or marketing which could delay or prevent licensing, sales-based royalties and/or milestone revenue.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Before we or our partners obtain the approvals necessary to sell any of our unpartnered assets or partnered programs, we must show through preclinical studies and human testing that each potential product is safe and effective.  We and/or our partners have a number of partnered programs and unpartnered assets moving toward or currently awaiting regulatory action.  Failure to show any product's safety and effectiveness could delay or prevent regulatory approval of a product and could adversely affect our business.  The drug development and clinical trials process is complex and uncertain.  For example, the results of preclinical studies and initial clinical trials may not necessarily predict the results from later large-scale clinical trials.  In addition, clinical trials may not demonstrate a product's safety and effectiveness to the satisfaction of the regulatory authorities.  A number of companies have suffered significant setbacks in advanced clinical trials or in seeking regulatory approvals, despite promising results in earlier trials.  The FDA may also require additional clinical trials after regulatory approvals are received.  Such additional trials may be expensive and time-consuming, and failure to successfully conduct those trials could jeopardize continued commercialization of a product.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The speed at which we and our partners complete our scientific studies and clinical trials depends on many factors, including, but not limited to, the ability to obtain adequate supplies of the products to be tested and patient enrollment.  Patient enrollment is a function of many factors, including the size of the patient population, the proximity of patients to clinical sites, the eligibility criteria for the trial and other potential drug candidates being studied.  Delays in patient enrollment for our or our partners&#8217; trials may result in increased costs and longer development times.  In addition, our partners have rights to control product development and clinical programs for products developed under our collaborations.  As a result, these partners may conduct these programs more slowly or in a different manner than expected.  Moreover, even if clinical trials are completed, we or our partners still may not apply for FDA or foreign regulatory approval in a timely manner or the FDA or foreign regulatory authority still may not grant approval.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our drug discovery, early-stage drug development, and product reformulation programs may require substantial additional capital to complete successfully.  Our partner's drug development programs may require substantial additional capital to complete successfully, arising from costs to: conduct research, preclinical testing and human studies; establish pilot scale and commercial scale manufacturing processes and facilities; and establish and develop quality control, regulatory, marketing, sales and administrative capabilities to support these programs.  While we expect to fund our research and development activities from cash generated from operations to the extent possible, if we are unable to do so, we may need to complete additional equity or debt financings or seek other external means of financing.  These financings could depress our stock price.  If additional funds are required to support our operations and we are unable to obtain them on terms favorable to us, we may be required to cease or reduce further development or commercialization of our products, to sell some or all of our technology or assets or to merge with another entity.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our OmniAb antibody platform faces specific risks, including the fact that no drug using antibodies from the platform has yet advanced to late stage clinical trials.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None of our collaboration partners using our OmniAb antibody platform have tested drugs based on the platform in late stage clinical trials and, therefore, none of our OmniAb collaboration partners&#8217; drugs have received FDA approval.  If one of our OmniAb collaboration partners&#8217; drug candidates fails during preclinical studies or clinical trials, our other OmniAb collaboration partners may decide to abandon drugs using antibodies generated from the OmniAb platform, whether or not attributable to the platform.  All of our OmniAb collaboration partners may terminate their programs at any time without penalty.  In addition, our OmniRat and OmniFlic platforms, which we consider the most promising, are covered by two patents within the U.S. and two patents in the European Union and are subject to the same risks as our patent portfolio discussed above, including the risk that our patents may infringe on third party patent rights or that our patents may be invalidated.  Further, we face significant competition from other companies selling human antibody-generating rodents, especially mice which compete with our OmniMouse platform, including the VelocImmune mouse, the AlivaMab mouse, the Trianni mouse and the Kymouse.  Many of our competitors have greater financial, technical and human resources than we do and may be better equipped to develop, manufacture and market competing antibody platforms.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">If plaintiffs bring product liability lawsuits against us or our partners, we or our partners may incur substantial liabilities and may be required to limit commercialization of our approved products and product candidates.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As is common in our industry, our partners and we face an inherent risk of product liability as a result of the clinical testing of our product candidates in clinical trials and face an even greater risk for commercialized products. Although we are not currently a party to product liability litigation, if we are sued, we may be held liable if any product or product candidate we develop causes injury or is found otherwise unsuitable during product testing, manufacturing, marketing or sale. Regardless of</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">27</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> merit or eventual outcome, liability claims may result in decreased demand for any product candidates, partnered products or products that we may develop, injury to our reputation, discontinuation of clinical trials, costs to defend litigation, substantial monetary awards to clinical trial participants or patients, loss of revenue and product recall or withdrawal from the market and the inability to commercialize any products that we develop. We have product liability insurance that covers our clinical trials up to a $10.0&#160;million annual limit. Our insurance coverage may not be sufficient to cover all of our product liability related expenses or losses and may not cover us for any expenses or losses we may suffer.  If we are sued for any injury caused by our product candidates, partnered products or any future products, our liability could exceed our total assets.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Market acceptance and sales of any approved product will depend significantly on the availability and adequacy of coverage and reimbursement from third-party payors and may be affected by existing and future healthcare reform measures.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Sales of the products we license to our collaboration partners and the royalties we receive will depend in large part on the extent to which coverage and reimbursement is available from government and health administration authorities, private health maintenance organizations and health insurers, and other healthcare payors. Significant uncertainty exists as to the reimbursement status of healthcare products. Healthcare payors, including Medicare, are challenging the prices charged for medical products and services. Government and other healthcare payors are increasingly attempting to contain healthcare costs by limiting both coverage and the level of reimbursement for medical products. Even if a product is approved by the FDA, insurance coverage may not be available, and reimbursement levels may be inadequate, to cover the costs associated with the research, development, marketing and sale of the product. If government and other healthcare payors do not provide adequate coverage and reimbursement levels for any product, market acceptance and any sales could be reduced.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">From time to time, legislation is implemented to reign in rising healthcare expenditures. By way of example, in March 2010, the Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act, or collectively, the ACA, was enacted, which included a number of provisions affecting the pharmaceutical industry, including, among other things, annual, non-deductible fees on any entity that manufactures or imports some types of branded prescription drugs and increases in Medicaid rebates owed by manufacturers under the Medicaid Drug Rebate Program. Since its enactment, there have been judicial and Congressional challenges to certain aspects of the ACA, and we expect there will be additional challenges and amendments to the ACA in the future.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Other legislative changes have been proposed and adopted since the ACA was enacted, including aggregate reductions of Medicare payments to providers of 2% per fiscal year and reduced payments to several types of Medicare providers. Moreover, there has recently been heightened governmental scrutiny over the manner in which manufacturers set prices for their marketed products, which has resulted in several Congressional inquiries and proposed bills designed to, among other things, bring more transparency to product pricing, review the relationship between pricing and manufacturer patient programs, and reform government program reimbursement methodologies for drug products. Individual states in the United States have also become increasingly active in implementing regulations designed to control pharmaceutical product pricing, including price or patient reimbursement constraints, discounts, restrictions on certain product access and marketing cost disclosure and transparency measures, and, in some cases, designed to encourage importation from other countries and bulk purchasing. We cannot predict whether other legislative changes will be adopted, if any, or how such changes would affect our operations or financial condition.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We and our collaboration partners may be subject to federal and state healthcare laws, including fraud and abuse, false claims, physician payment transparency and health information privacy and security laws. Our operations and those of our collaboration partners are subject to various federal and state fraud and abuse laws, including, without limitation, anti-kickback, false claims and physician payment transparency statutes. These laws may impact, among other things, financial arrangements with physicians, sales, marketing and education programs and the manner in which any of those activities are implemented. In addition, we may be subject to federal and state patient privacy regulations. If our operations or those of our collaboration partners are found to be in violation of any of those laws or any other applicable governmental regulations, we or our collaboration partners may be subject to penalties, including civil and criminal penalties, damages, fines, imprisonment, exclusion from government healthcare programs or the curtailment or restructuring of operations, any of which could adversely affect our ability to operate our business and our financial condition.</span></div><div><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:115%;">Changes in funding for the FDA and other government agencies could hinder their ability to hire and retain key leadership and other personnel, or otherwise prevent new products and services from being developed or commercialized in a timely manner, which could negatively impact our business or the business of our partners.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">The ability of the FDA to review and approve new products can be affected by a variety of factors, including government budget and funding levels, ability to hire and retain key personnel and accept the payment of user fees, and statutory, regulatory,</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">28</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"> and policy changes. Average review times at the agency have fluctuated in recent years as a result. In addition, government funding of other government agencies that fund research and development activities is subject to the political process, which is inherently fluid and unpredictable.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Disruptions at the FDA and other agencies may also slow the time necessary for new drugs to be reviewed and/or approved by necessary government agencies, which would adversely affect our business or the business of our partners.  For example, over the last several years, including for 35 days beginning on December 22, 2018, the U.S. government has shut down several times and certain regulatory agencies, such as the FDA, have had to furlough critical FDA employees and stop critical activities. If a prolonged government shutdown occurs, it could significantly impact the ability of the FDA to timely review and process our regulatory submissions, which could have a material adverse effect on our business.  If the timing of FDA&#8217;s review and approval of new products is delayed, the timing of our or our partners&#8217; development process may be delayed which would result in delayed milestone revenues and materially harm our operations of business.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Any difficulties from strategic acquisitions could adversely affect our stock price, operating results and results of operations.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We may acquire companies, businesses and products that complement or augment our existing business. We may not be able to integrate any acquired business successfully or operate any acquired business profitably. Integrating any newly acquired business could be expensive and time-consuming. Integration efforts often take a significant amount of time, place a significant strain on managerial, operational and financial resources and could prove to be more difficult or expensive than we predict. The diversion of our management's attention and any delay or difficulties encountered in connection with any future acquisitions we may consummate could result in the disruption of our ongoing business or inconsistencies in standards and controls that could negatively affect our ability to maintain third-party relationships. Moreover, we may need to raise additional funds through public or private debt or equity financing, or issue additional shares, to acquire any businesses or products, which may result in dilution for stockholders or the incurrence of indebtedness.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As part of our efforts to acquire companies, business or product candidates or to enter into other significant transactions, we conduct business, legal and financial due diligence with the goal of identifying and evaluating material risks involved in the transaction. Despite our efforts, we ultimately may be unsuccessful in ascertaining or evaluating all such risks and, as a result, might not realize the intended advantages of the transaction. If we fail to realize the expected benefits from acquisitions we may consummate in the future or have consummated in the past, whether as a result of unidentified risks, integration difficulties, regulatory setbacks, litigation with current or former employees and other events, our business, results of operations and financial condition could be adversely affected. If we acquire product candidates, we will also need to make certain assumptions about, among other things, development costs, the likelihood of receiving regulatory approval and the market for such product candidates. Our assumptions may prove to be incorrect, which could cause us to fail to realize the anticipated benefits of these transactions.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In addition, we will likely experience significant charges to earnings in connection with our efforts, if any, to consummate acquisitions. For transactions that are ultimately not consummated, these charges may include fees and expenses for investment bankers, attorneys, accountants and other advisors in connection with our efforts. Even if our efforts are successful, we may incur, as part of a transaction, substantial charges for closure costs associated with elimination of duplicate operations and facilities and acquired IPR&amp;D charges. In either case, the incurrence of these charges could adversely affect our results of operations for particular quarterly or annual periods.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Changes or modifications in financial accounting standards, including those related to revenue recognition, may harm our results of operations.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">From time to time, the FASB either alone or jointly with other organizations, promulgates new accounting principles that could have an adverse impact on our results of operations. For example, in May 2014, FASB issued a new accounting standard for revenue recognition-Accounting Standards Codification Topic 606, Revenue from Contracts with Customers, or ASC 606-that supersedes most current revenue recognition guidance.  The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services.  The new guidance became effective in fiscal 2018. </span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">This standard has a material impact on our consolidated financial statements by accelerating the timing of revenue recognition for revenues related to royalties, and potentially certain contingent milestone based payments. Our practice has been to book royalties one quarter after our partners report sales of the underlying product. Now, under ASC 606, Ligand estimates and books royalties in the same quarter that our partners report the sale of the underlying product. As a result, we now book royalties one quarter earlier compared to our past practice.  We rely on our partners&#8217; earning releases and other information from our partners to determine the sales of our partners&#8217; products and to estimate the related royalty revenues.  If our partners report</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">29</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> incorrect sales, or if our partners delay reporting of their earnings release, our royalty estimates may need to be revised and/or our financial reporting may be delayed. </span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Any difficulties in implementing this guidance could cause us to fail to meet our financial reporting obligations, which could result in regulatory discipline and harm investors&#8217; confidence in us. Finally, if we were to change our critical accounting estimates, including those related to the recognition of license revenue and other revenue sources, our operating results could be significantly affected.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Uncertainties in the interpretation&#160;and&#160;application of the 2017&#160;Tax&#160;Cuts&#160;and&#160;Jobs&#160;Act&#160;could materially affect our&#160;tax&#160;obligations&#160;and&#160;effective&#160;tax&#160;rate.&#160;</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The 2017&#160;Tax&#160;Cuts&#160;and&#160;Jobs&#160;Act&#160;(the&#160;Tax&#160;Act) was enacted on December 22, 2017, and significantly affected U.S. tax law,&#160;including by changing how the U.S. imposes tax on certain types of income of corporations and by reducing the general U.S. corporate income tax rate. The U.S. Department of Treasury has broad authority to issue regulations and interpretative guidance that may significantly impact how we will apply the law and impact our results of operations in the period issued.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Tax Act requires certain complex computations not previously provided in U.S. tax law. As such, the application of accounting guidance for such items is currently uncertain. Further, compliance with the Tax Act and the accounting for such provisions require accumulation of certain information not previously required or regularly produced. As a result, we have provided a provisional estimate on the effect of the Tax Act in our financial statements. As additional and other regulatory guidance is issued by the applicable taxing authorities, as accounting treatment is clarified, as we perform additional analysis on the application of the law, and as we refine estimates in calculating the effect, our final analysis, which will be recorded in the period completed, may be different from our current provisional amounts, which could materially affect our tax obligations and effective tax rate.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our ability to use our net operating loss carryforwards and certain other tax attributes to offset future taxable income may be subject to certain limitations. </span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, we had U.S. federal and state net operating loss carryforwards (NOLs) of approximately $229.9 million and $125.3 million, respectively, which expire through 2037, if not utilized. Under the Tax Act, any federal NOLs arising in taxable years ending after December 31, 2017 will carry forward indefinitely. As of December&#160;31, 2018, we had federal and California research and development tax credit carryforwards of approximately $23.0 million and $22.7 million, respectively. The federal research and development tax credit carryforwards expire in various years through 2037, if not utilized. The California research and development credit will carry forward indefinitely. Under Sections 382 and 383 of Internal Revenue Code of 1986, as amended (Code) if a corporation undergoes an &#8220;ownership change,&#8221; the corporation&#8217;s ability to use its pre-change NOLs and other pre-change tax attributes, such as research tax credits, to offset its future post-change income and taxes may be limited. In general, an &#8220;ownership change&#8221; occurs if there is a cumulative change in our ownership by &#8220;5% shareholders&#8221; that exceeds 50 percentage points over a rolling three-year period. Similar rules may apply under state tax laws. We believe we have experienced certain ownership changes in the past and have reduced our deferred tax assets related to NOLs and research and development tax credit carryforwards accordingly. In the event that it is determined that we have in the past experienced additional ownership changes, or if we experience one or more ownership changes as a result future transactions in our stock, then we may be further limited in our ability to use our NOLs and other tax assets to reduce taxes owed on the net taxable income that we earn in the event that we attain profitability. Furthermore, under the Tax Act, although the treatment of tax losses generated in tax years beginning before December 31, 2017 has generally not changed, tax losses generated in tax years beginning after December 31, 2017 may only offset 80% of our taxable income. This change may require us to pay federal income taxes in future years despite having potentially&#160;generated a loss for federal income tax purposes in prior years. Any such limitations on the ability to use our NOLs and other tax assets could adversely impact our business, financial condition and operating results.  </span></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">30</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">We rely on information technology and any failure, inadequacy, interruption or security lapse of that technology, including any cyber security incidents, could harm our ability to operate our business effectively.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our business is increasingly dependent on critical, complex and interdependent information technology systems, including internet-based systems, to support business processes as well as internal and external communications.  Despite the implementation of security measures, our internal computer systems and those of our partners are vulnerable to damage from cyber-attacks, computer viruses, security breaches, unauthorized access, natural disasters, terrorism, war and telecommunication and electrical failures. System failures, accidents or security breaches could cause interruptions in our operations, could lead to the loss of trade secrets or other intellectual property, could lead to the public exposure of personal information of our employees and others, and could result in a material disruption of our clinical and commercialization activities and business operations, in addition to possibly requiring substantial expenditures to remedy. To the extent that any disruption or security breach were to result in a loss of, or damage to, our data or applications, or inappropriate disclosure of confidential or proprietary information, we could incur liability and our business and financial condition could be harmed.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">The occurrence of a catastrophic disaster could damage our facilities beyond insurance limits or we could lose key data which could cause us to curtail or cease operations.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We are vulnerable to damage and/or loss of vital data from natural disasters, such as earthquakes, tornadoes, power loss, fire, floods and similar events, as well as from accidental loss or destruction. If any disaster were to occur, our ability to operate our business could be seriously impaired. We have property, liability, and business interruption insurance which may not be adequate to cover our losses resulting from disasters or other similar significant business interruptions, and we do not plan to purchase additional insurance to cover such losses due to the cost of obtaining such coverage. Any significant losses that are not recoverable under our insurance policies could seriously impair our business, financial condition and prospects.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Conversion of our outstanding convertible notes may result in losses, result in the dilution of existing stockholders, create downward pressure on the price of our common stock, and restrict our ability to take advantage of future opportunities.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">In August 2014, we issued $245.0 million principal amount of the 2019 Notes and in May 2018, we issued $750.0 million principle amount of the 2023 Notes. The sale of the 2019 Notes and 2023 Notes may affect our earnings per share figures, as accounting procedures require that we include in our calculation of earnings per share the number of shares of our common stock into which the 2019 Notes and 2023 Notes are convertible. The convertible notes may be converted into cash and shares of our common stock, if any (subject to our right or obligation to pay cash in lieu of all or a portion of such shares).  If shares of our common stock are issued to the holders of the convertible notes upon conversion, there will be dilution to our shareholders equity and the market price of our shares may decrease due to the additional selling pressure in the market. Any downward pressure on the price of our common stock caused by the sale or potential sale of shares issuable upon conversion of the convertible notes could also encourage short sales by third parties, creating additional selling pressure on our stock.  Upon the occurrence of certain circumstances, holders of the convertible notes may require us to purchase all or a portion of their notes for cash, which may require the use of a substantial amount of cash. In addition, we must use cash to settle the principal and any premium due upon conversion of the 2019 Notes for any conversion notices received on or after May 22, 2018.   If such cash is not available, we may be required to sell other assets or enter into alternate financing arrangements at terms that may or may not be desirable. The existence of the convertible notes and the obligations that we incurred by issuing them may restrict our ability to take advantage of certain future opportunities, such as engaging in future debt or equity financing activities. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">As of December 31, 2018, we had $27.3 million&#160;aggregate principal amount of 2019 Notes, and $750.0 million aggregate principal amount of 2023 Notes. The notes are convertible into cash, and if applicable, shares of our common stock under certain circumstances, including trading price conditions related to our common stock. Upon conversion, we are required to record a gain or loss for the difference between the fair value of the notes to be extinguished and their corresponding net carrying value. The fair value of the notes to be extinguished depends on our current incremental borrowing rate. If our incremental borrowing rate at the time of conversion is lower than the implied interest rate of the notes, we will record a loss in our consolidated statement of income during the period in which the notes are converted. </span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:8pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Impairment charges pertaining to goodwill, identifiable intangible assets or other long-lived assets from our mergers and acquisitions could have an adverse impact on our results of operations and the market value of our common stock.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The total purchase price pertaining to our acquisitions in recent years of Vernalis, CyDex, Metabasis, Pharmacopeia, Neurogen, OMT and Crystal have been allocated to net tangible assets, identifiable intangible assets, in-process research and development and goodwill. To the extent the value of goodwill or identifiable intangible assets or other long-lived assets</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">31</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> become impaired, we will be required to incur material charges relating to the impairment. Any impairment charges could have a material adverse impact on our results of operations and the market value of our common stock.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our charter documents and concentration of ownership may hinder or prevent change of control transactions.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Provisions contained in our certificate of incorporation and bylaws may discourage transactions involving an actual or potential change in our ownership.  In addition, our Board of Directors may issue shares of common or preferred stock without any further action by the stockholders.  Our directors and certain of our institutional investors collectively beneficially own a significant portion of our outstanding common stock. Such provisions and issuances may have the effect of delaying or preventing a change in our ownership.  If changes in our ownership are discouraged, delayed or prevented, it would be more difficult for our current Board of Directors to be removed and replaced, even if you or our other stockholders believe that such actions are in the best interests of us and our stockholders.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our stock price has been volatile and could experience a sudden decline in value.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The market prices for securities of biotechnology and pharmaceutical companies have historically been highly volatile, and the market has recently experienced significant price and volume fluctuations that are unrelated to the operating performance of particular companies. Continued volatility in the overall capital markets could reduce the market price of our common stock in spite of our operating performance. Further, high stock price volatility could result in higher share-based compensation expense.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our common stock has experienced significant price and volume fluctuations and may continue to experience volatility in the future.  Many factors may have a significant impact on the market price of our common stock, including, but not limited to, the following factors: results of or delays in our preclinical studies and clinical trials; the success of our collaboration agreements; publicity regarding actual or potential medical results relating to products under development by us or others; announcements of technological innovations or new commercial products by us or others; developments in patent or other proprietary rights by us or others; comments or opinions by securities analysts or major stockholders or changed securities analysts' reports or recommendations; future sales or shorting of our common stock by existing stockholders; regulatory developments or changes in regulatory guidance; litigation or threats of litigation; economic and other external factors or other disaster or crises; the departure of any of our officers, directors or key employees; period-to-period fluctuations in financial results; and price and volume fluctuations in the overall stock market.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Our results of operations and liquidity needs could be materially negatively affected by market fluctuations and economic downturn.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our results of operations could be materially negatively affected by economic conditions generally, both in the United States and elsewhere around the world. Concerns over inflation, energy costs, geopolitical issues, the availability and cost of credit, and the U.S. financial markets have in the past contributed to, and may continue in the future to contribute to, increased volatility and diminished expectations for the economy and the markets.  Domestic and international equity markets periodically experience heightened volatility and turmoil. These events may have an adverse effect on us. In the event of a market downturn, our results of operations could be adversely affected by those factors in many ways, including making it more difficult for us to raise funds if necessary, and our stock price may further decline. We cannot provide assurance that our investments are not subject to adverse changes in market value. If our investments experience adverse changes in market value, we may have less capital to fund our operations.</span></div><div><span><br/></span></div><div id="i_0_77"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;1B.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unresolved Staff Comments</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None. </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_89"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;2.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Properties</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We currently lease premises consisting of approximately 5,000 square feet of office space in San Diego which serves as our corporate headquarters. The lease expires in April 2023.</span></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We lease approximately 1,500 square feet of laboratory space located at the Bioscience and Technology Business Center in Lawrence, Kansas. The lease expires in December&#160;2020.</span></div><div style="text-indent:24pt;margin-top:9pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">32</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We lease approximately 13,000 square feet of office and laboratory space located in Emeryville, California. The lease expires in August 2021. </span></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the Vernalis&#160;acquisition in October 2018, we lease approximately 28,000 square feet of office and laboratory space located in Cambridge, United Kingdom. The lease expires in September 2019, and we are currently working with the landlord on potential renewal options.</span></div><div><span><br/></span></div><div id="i_0_101"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;3.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Legal Proceedings</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">See &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (9), Commitments and Contingencies&#8212;Legal Proceedings.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div><span><br/></span></div><div id="i_0_113"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;4.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Mine Safety Disclosures</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Not applicable.</span></div><div id="i_0_125"></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">PART II</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div id="i_0_137"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;5.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Market for Registrant&#8217;s Common Equity, Related Stockholder Matters, and Issuer Purchases of Equity Securities</span></td></tr></table></div><div style="margin-top:5pt;"><span><br/></span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our common stock is traded on the Nasdaq Global&#160;Market under the symbol &#8220;LGND.&#8221;&#160;As of February&#160;15, 2019, there were approximately 523 holders of record of the common stock.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Except for 2007, during which we declared a cash dividend on our common stock of $2.50 per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future. We expect to retain our future earnings, if any, for use in the operation and expansion of our business, to pay down debt and potentially for share repurchases. Any future determination to pay dividends on common stock will be at the discretion of our board of directors and will depend upon our financial condition, results of operations, capital requirements and such other factors as the board deems relevant.&#160;</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table presents information regarding repurchases by us of our common stock during the three months ended December 31, 2018 under the stock repurchase program approved by our board of directors in September 2018, under which we may acquire up to $200 million of our common stock in open market and negotiated purchases for a period of up to three years.&#160;</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:120%;">ISSUER PURCHASES OF EQUITY SECURITIES</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:35.591777%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.524229%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.041116%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:2.149486%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.691630%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.121586%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.096916%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.562115%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:15.621145%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;&#160;&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Total&#160;Number&#160;of</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Shares&#160;Purchased</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Average&#160;Price&#160;Paid</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Per Share</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Total&#160;Number&#160;of</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Shares&#160;Purchased&#160;as</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Part of Publicly</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Announced Plans or</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Programs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Maximum&#160;Dollar&#160;Value&#160;of</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Shares that May Yet Be</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">Purchased Under the&#160;</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">&#160;Program                              </span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:100%;">(in thousands)</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">October 1 - October 31, 2018</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">200,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">November 1 - November 30, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">295,210&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">152.83&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">295,210&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">154,883&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 1 - December 31, 2018</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">208,038&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">142.46&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">208,038&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125,246&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;&#160;&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">503,248&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">148.54&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">503,248&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr></table></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:13pt;line-height:120%;">&#160;</span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 23, 2019, the board of directors elected to increase the existing $200 million share repurchase program, authorizing us to repurchase up to a maximum of $350 million of its outstanding common stock under the repurchase program. The repurchase program will expire, as originally scheduled, on September 20, 2021. Since December 31, 2018 and as of February 28, 2019, we acquired&#160;400,177&#160;additional shares during 2019, and the maximum dollar value of shares that may yet be purchased under the repurchase program was $225.9 million.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">33</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In addition, in May 2018, we issued the 2023 Notes with an aggregate principal amount of $750.0 million. A portion of the proceeds from such issuance totaling $49.7 million were used to repurchase 260,000 shares of our common stock. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The information required by Item 201(d) of Regulation S-K is incorporated by reference to the 2019 Annual Meeting Proxy Statement as defined in Item 10 below.</span></div><div style="text-indent:24pt;margin-top:5pt;"><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Performance Graph</span></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The graph below shows the five-year cumulative total stockholder return assuming the investment of $100 and is based on the returns of the component companies weighted monthly according to their market capitalizations. The graph compares total stockholder returns of our common stock, of all companies traded on the Nasdaq Stock market, as represented by the Nasdaq Composite</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;line-height:120%;vertical-align:top;">&#174;</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Index, and of the Nasdaq Biotechnology Stock Index, as prepared by The Nasdaq Stock Market Inc.</span></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The stockholder return shown on the graph below is not necessarily indicative of future performance and we will not make or endorse any predictions as to future stockholder returns.</span></div><div style="text-indent:24pt;margin-top:9pt;"><img src="lgnd-20181231_g2.jpg" alt="lgnd-20181231_g2.jpg" style="height:331;width:684;"></img></div><div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:90.497076%;"><tr><td style="width:1.0%;"></td><td style="width:36.933764%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.607754%;"></td><td style="width:0.1%;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td style="width:1.0%;"></td><td style="width:7.369952%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.446204%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.369952%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.607754%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.369952%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.607754%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.208401%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.607754%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.693053%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.607754%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.369952%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2013</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2014</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2015</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12/31/2018</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">100.00&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.16&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">206.12&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">193.17&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">260.32&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">257.98&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NASDAQ Composite-Total Return</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">100.00&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">114.75&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">122.74&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">133.62&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173.22&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">168.30&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">NASDAQ Biotechnology Index</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">100.00&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">134.40&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">150.22&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">118.15&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143.74&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">131.00&#160;</span></td></tr></table></div><div style="text-align:center;margin-top:9pt;"><span><br/></span></div><div style="margin-top:9pt;"><span><br/></span></div><div id="i_0_149"></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">34</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;6.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selected Consolidated Financial Data</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following selected historical consolidated financial and other data are qualified by reference to, and should be read in conjunction with, our consolidated financial statements and the related notes thereto appearing elsewhere herein and &#8220;Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations.&#8221; Our selected statement of operations data set forth below for each of the years ended December&#160;31, 2018, 2017, 2016, 2015&#160;and 2014 and the balance sheet data as of December&#160;31, 2018, 2017, 2016, 2015&#160;and 2014 are derived from our consolidated financial statements.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:40.836257%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.818713%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.384795%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.818713%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.672515%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.672515%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.672515%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December 31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2015</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2014</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Consolidated Statements of Operations Data:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="24" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands, except per share amounts)</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">128,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">88,685&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,423&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,194&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,994&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material sales</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,123&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,070&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,502&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,662&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">28,488&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones, and other revenues</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93,774&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,347&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,048&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,058&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,056&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total revenues</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">251,453&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">141,102&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">108,973&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">71,914&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">64,538&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cost of material sales</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,337&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,366&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,571&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,807&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,136&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amortization of intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">15,792&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,120&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,643&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,375&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,375&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,863&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,887&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,221&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,005&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,747&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">37,734&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">28,653&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,653&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">25,398&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,654&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">87,726&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">73,026&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">65,088&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,585&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,912&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income from operations </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">163,727&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">68,076&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43,885&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,329&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,626&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from continuing operations including noncontrolling interests</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,321&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,367)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">227,444&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,892&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Loss attributable to noncontrolling interests</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,380)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,132)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from continuing operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,321&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,367)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">229,824&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,024&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">731&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,321&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,636)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">229,824&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,024&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from continuing operations</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.77&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.60&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.11)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.61&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.59&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.04&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.77&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.60&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.08)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.61&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.59&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average number of common shares-basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,160&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,032&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,790&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,419&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from continuing operations</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.96&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.53&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.11)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.83&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.56&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.04&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.96&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.53&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.08)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.83&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.56&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average number of common shares-diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,067&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,481&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,228&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,433&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div><span><br/></span></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">35</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"></td><td style="width:43.722714%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.324484%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.176991%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.176991%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.324484%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.324484%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="27" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2015</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2014</span></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="27" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands)</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Consolidated Balance Sheet Data:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash, cash equivalents, short-term investments, restricted cash and investments</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">767,188&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">208,099&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">149,393&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">229,947&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">168,597&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Working capital (deficit)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">788,291&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,847)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(64,076)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(8,109)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">162,379&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,260,803&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">671,021&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">601,585&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">503,061&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">258,029&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other long-term obligations (excludes long-term portions of deferred revenue, net and deferred gain)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,776&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,981&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,603&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,330&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">208,757&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total notes payable, net (including current portion)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">636,297&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">224,529&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">212,910&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">201,985&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">195,908&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accumulated deficit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(229,197)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(400,924)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"> &#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(429,491)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(659,315)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total stockholders&#8217; equity</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">560,914&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">399,788&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">341,290&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">237,282&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,318&#160;</span></td></tr></table></div><div style="margin-bottom:6pt;"><span><br/></span></div><div><span><br/></span></div><div id="i_0_161"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;7.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations</span></td></tr></table></div><div><span><br/></span></div><div id="i_0_173"></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our Management's Discussion and Analysis of Financial Condition and Results of Operations (MD&amp;A) will help readers understand our results of operations, financial condition, and cash flow. It is provided in addition to the accompanying consolidated financial statements and notes. This MD&amp;A is organized as follows:</span></div><div style="text-indent:-18pt;padding-left:36pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Results of Operations.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Detailed discussion of our revenue and expenses.</span></div><div style="text-indent:-18pt;padding-left:36pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Liquidity</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"> and Capital Resources.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Discussion of key aspects of our consolidated statements of cash flows, changes in our financial position, and our financial&#160;commitments.</span></div><div style="text-indent:-18pt;padding-left:36pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Off-</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Balance Sheet Arrangements. </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have no off-balance sheet arrangements.</span></div><div style="text-indent:-18pt;padding-left:36pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Contractual Obligations.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> Tabular disclosure of known contractual obligations as of December 31, 2018.</span></div><div style="text-indent:-18pt;padding-left:36pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Critical Accounting Policies and Estimates. </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Discussion of significant changes we believe are important to understand the assumptions and judgments underlying our consolidated financial statements.</span></div><div style="text-indent:-18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;padding-left:14.5pt;">Recent Accounting </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Pronouncements.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;For summary of recent accounting pronouncements applicable to our consolidated financial statements, see &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (1), Basis of Presentation and Summary of Significant Accounting Policies</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#8221;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Results of Operations</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Revenue</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"></td><td style="width:30.595870%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.997050%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Dollars in thousands)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalty Revenue</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">128,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">88,685&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">39,871&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">45&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,423&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,262&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">49&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material Sales</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,123&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,070&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,053&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">32&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,502&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(432)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones and other revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93,774&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,347&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">63,427&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">209&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,048&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,299&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenue</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">251,453&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">141,102&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">110,351&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">78&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">108,973&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">32,129&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr></table></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We adopted ASC 606, the new revenue standard, in the first quarter of 2018 and now recognize royalties on sales of products&#160;commercialized by our partners in the quarter the product is sold as opposed to on a one-quarter lag as previously recognized under ASC&#160;605, the legacy revenue standard. The results for the reporting periods beginning after January 1, 2018 are presented in accordance with the&#160;new standard, although comparative information has not been restated and continues to be reported under the accounting standards and&#160;policies in effect for those periods.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">36</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Royalty revenue is a function of our partners' product sales and the applicable royalty rate. Promacta and Kyprolis royalty rates are&#160;under a tiered royalty rate structure with the highest tier being 9.4% and 3.0%, respectively. Evomela has a fixed royalty rate of 20%.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Total revenue for 2018 increased $110.4 million or 78% compared with 2017 and for 2017 it increased $32.1 million  or 29% compared with 2016.  </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Royalty revenue increased in each year presented primarily due to an increase in sales by our partners of Promacta and Kyprolis. Material sales increased year over year in 2018 due to timing of customer purchases of Captisol for use in clinical trials and in commercialized products. The increase in license fee, milestones and other revenues in 2018 compared to 2017 is primarily driven by a $47.0 million OmniAb platform license fee received from WuXi and $20.0 million received from Roivant upon entering into the GRA license agreement to develop and commercialize RVT-1502 (formerly named LGD-6972). The increase in license fees, milestones and other revenues in 2017 compared to 2016 was primarily due to OmniAb license fees and milestone payments.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table represents royalty revenue by program under the new (ASC 606) and prior (ASC 605) revenue standard:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:7.210526%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.210526%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.823392%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.210526%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.823392%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.210526%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.380117%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in millions)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018 Estimated Partner Product Sales&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Effective Royalty Rate&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018 Royalty Revenue under ASC 606&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018 Product Sales reported on quarter lag&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Effective Royalty Rate&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018 Royalty Revenue under ASC 605&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017 Product Sales reported on quarter lag&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Effective Royalty Rate&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017 Royalty Revenue under ASC 605&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Promacta&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,173.4&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.5&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">99.3&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,098.4&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.4&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">92.3&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">787.6&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.0&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">62.9&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Kyprolis&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">980.5&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.2&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21.7&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">947.5&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.2&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20.9&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">817.0&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16.4&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Evomela&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">28.1&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20.0&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.7&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">28.6&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20.0&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.7&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">35.8&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20.0&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.2&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">163.5&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.2&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.9&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">162.0&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.3&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">155.7&#160;</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.4&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.2&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,345.5&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">128.6&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,236.5&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">121.0&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,796.1&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">88.7&#160;</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Operating Costs and Expenses</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"></td><td style="width:30.544379%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.875740%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.023669%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Dollars in thousands)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cost of material sales</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,337&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,366&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">18&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,571&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(205)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amortization of intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">15,792&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,120&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,672&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,643&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,477&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,863&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,887&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">976&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,221&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,666&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">37,734&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">28,653&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,081&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">32&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,653&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">87,726&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">73,026&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,700&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">65,088&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,938&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Total operating costs and expenses for 2018 increased $14.7 million or 20% compared with 2017, while total operating costs and expenses as a percentage of revenue decreased in 2018 as compared to 2017. Cost of material sales increased year over year in 2018 primarily due to higher material sales as a result of timing of customer purchases. Amortization of intangibles increased year over year in 2018 due primarily due to the Crystal acquisition in the fourth quarter of 2017, the Vernalis acquisition in the fourth quarter of 2018 and amortization of previous indefinite&#160;lived IPR&amp;D assets that were out-licensed or impaired.&#160;General and administrative expenses increased year over year in 2018 primarily due to&#160;increased business development activities, an increase in share-based compensation&#160;and the Vernalis&#160;acquisition.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Total operating costs and expenses for 2017 increased $7.9 million or 12% compared with 2016, while the total operating costs and expenses as a percentage of revenue decreased in 2017 as compared to 2016. Cost of material sales decreased year over year in 2017 primarily due to lower material sales as a result of timing of customer purchases. Amortization of intangibles increased year over year in 2017 due primarily to the acquisition of Crystal in October 2017. Research and development expenses and general and administrative expenses increased year over year in 2017 due primarily to increased business development activities, timing of internal development costs and increased share-based compensation expense and headcount related expenses associated with Crystal.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">37</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We do not provide forward-looking estimates of costs and time to complete our ongoing research and development projects as such estimates would involve a high degree of uncertainty. Uncertainties include our inability to predict the outcome of research and clinical studies, regulatory requirements placed upon us by regulatory authorities such as the FDA and EMA, our inability to predict the decisions of our partners, our ability to fund research and development programs, competition from other entities of which we may become aware in future periods, predictions of market potential for products that may be derived from our work, and our ability to recruit and retain personnel or third-party contractors with the necessary knowledge and skills to perform certain research. Refer to &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 1A. Risk Factors</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional discussion of the uncertainties surrounding our research and development initiatives.</span></div><div style="text-align:center;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Other income (expense)</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.099415%;"><tr><td style="width:1.0%;"></td><td style="width:29.594635%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.538003%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.941878%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.090909%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.090909%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.090909%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.090909%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.545156%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.090909%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Dollars in thousands)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gain (loss) from Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50,187&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,048)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">52,235&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,551)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(23,132)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,084&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(91)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest income</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">13,999&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,060&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,939&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">580&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">664&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,396&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">210&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(48,276)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(13,460)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(34,816)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">259&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(12,842)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(618)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other (expense) income, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,307)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,603&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(8,910)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(342)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(615)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,218&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(523)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total other income (expense,) net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,603&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,845)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,448&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(189)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(35,925)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">25,080&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(70)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In the first quarter of 2018, we discontinued accounting for our ownership interest in Viking common stock under the equity method&#160;and now account for Viking as an equity security with changes in the fair value of Viking common stock recorded as "Gain (loss) from&#160;Viking." The increase in gain (loss) from Viking is a result of a $42.4&#160;million unrealized gain recorded in 2018. In addition, gain (loss) from Viking in 2018 includes a realized gain of $2.5 million resulting from the sale of Viking shares as well as an unrealized gain relating to an increase in the&#160;market value of Viking warrants held by us of $5.4 million.&#160;</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2017, we recorded a $4.7 million loss from Viking for our proportionate share of Viking&#8217;s losses based on our ownership of Viking common stock and a $2.9 million gain on dilution resulting from Viking's financings.&#160;In 2016, we recorded a $5.0 million loss from Viking for our proportionate share of Viking&#8217;s losses based on our ownership of Viking common stock and $10.7 million for loss on dilution resulting from Viking's financing. Additionally, we recorded an impairment charge in 2016 of $7.4 million relating to our investment in Viking.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Interest income consists primarily of short-term investment transactions and the change in fair market value of the investments. The increase over the&#160;prior periods presented is due to the increase in our short-term investment balances which, in the current year, is&#160;a result of the 2023 Notes financing on May 22, 2018.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Interest expense includes the 0.75% coupon cash interest expense in addition to the $44.0 million non-cash accretion&#160;of discount on our 2019 Notes and 2023 Notes for the year ended December 31, 2018. The increase from prior year is primarily due to the issuance of the 2023 Notes in May 2018 and a $3.2 million loss on debt extinguishment resulting from  the&#160;settlement of a portion of our 2019 Notes in 2018. See &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (6), Convertible Senior Notes.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The increase in Other income (expense), net, in 2018 as compared to the prior year&#160;is due&#160;primarily to the increase in the fair value of contingent liabilities associated with our Metabasis acquisition and a net increase in our&#160;derivative instrument expense associated with our convertible notes and hedge transactions. See &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (6), Convertible Senior Notes.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;&#160;The year over year variance in Other expense (income), net, in 2017 as compared to 2016 is due to an increase in the fair value of the Viking note&#160;receivable and gain on the sale of short-term investments. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income tax expense</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">38</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:27.662261%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:6.810573%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.691630%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.544787%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.957416%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.544787%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.397944%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.985316%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Dollars in thousands)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">% Change</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income before income tax expense</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173,330&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">57,231&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">116,099&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">203&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$7,960&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">49,271&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">619&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(30,009)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(44,675)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,666&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(33)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,327)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(34,348)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from operations</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,321&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,556&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">130,765&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,041&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$(2,367)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,923&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(630)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Effective Tax Rate</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">78&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">130&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our effective tax rate for 2018, 2017 and 2016 was&#160;17%, 78%, and 130%, respectively. Our tax rate is affected by recurring items, such as the U.S. federal and state statutory tax rates and the relative amounts of income we earn in those jurisdictions, which we expect to be fairly consistent in the near term. It is also affected by discrete items that may occur in any given year, but are not consistent from year to year. In addition to state income taxes, the items below had the most significant impact on the difference between our statutory U.S. income tax rate and our effective tax rate.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;&#160;</span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">2018</span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">8.1 million (5%) decrease due to excess tax benefits from share-based compensation which are recorded as a discrete item within the provision for income tax pursuant to ASU 2016-09</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">4.2 million (2%) decrease due to changes in valuation allowance primarily relating to capital loss carryovers and research and development tax credits. </span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$3.1 million (</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">2%) increase from expired NOLs and credits</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">2.8 million (2%) reduction from research and development tax credits </span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">0.9 million (1%) increase from non-cash contingent consideration charges that are nondeductible for tax purposes</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$0</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.9 million (1%) increase from Section 162(m) limitation </span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">2017</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$32.4 million (55%) increase due to the provisional estimated impact of the Tax Act and primarily due to the impact of revaluing our U.S. deferred tax assets and liabilities based on the statutory rates at which they are expected to be recognized in the future, which for federal purposes was reduced from 35% to 21%</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$4.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">0 million (7%) decrease due to excess tax benefits from share-based compensation which are recorded as a discrete item within the provision for income tax pursuant to ASU 2016-09</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$4.2 million (7%) reduction due to decrease in valuation allowance primarily relating to our Viking deferred tax asset and change in corporate tax rates under the Tax Act</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$2.8 million (5%) reduction from </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">research and development tax credits </span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$1.3 million (2%) increase in uncertain tax positions</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$0.9 million (2%) increase from non-cash contingent </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">consideration charges that are nondeductible for tax purposes </span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">2016</span></div><div><span><br/></span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$6.3 million (79%) increase in valuation allowance primarily relating to Viking deferred tax asset  </span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$1.4 million (18%) increase in uncertain tax positions </span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$1.2 million (15%) increase from non-cash contingent </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">consideration charges that are nondeductible for tax purposes</span></div><div style="text-indent:-18pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">$1.5 million (19%) reduction from</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> research and development credits</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Discontinued operations</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel. Certain liabilities were recorded associated with the disposal of the product line. During the year ended December 31, 2016, we recognized a $1.1 million gain due to subsequent changes in certain estimates and liabilities previously recorded.  We recorded a provision for income taxes related to the gain of $0.4 million.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div id="i_0_185"></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">39</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Liquidity and Capital Resource</span></div><div style="text-indent:27pt;margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At December 31, 2018, we had approximately $117.2 million in cash and cash equivalents, of which approximately $7.5 million was held by our foreign subsidiaries. Cash and cash equivalents increased by $96.5 million from last year, due to factors described in the "Cash Flow Summary" below.&#160;Our primary source of liquidity, other than our holdings of cash, cash equivalents, and investments, has been cash flows from operations. Our ability to generate cash from operations provides us with the financial flexibility we need to meet operating, investing, and financing needs. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Historically, we have liquidated our short-term investments and/or issued debt and equity securities to finance our business needs as a supplement to cash provided by operating activities. As of December&#160;31, 2018, we had&#160;$601.2 million in short-term investments. Our short-term investments include U.S. government debt securities, investment-grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities of our investments in order to provide both safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates. Additionally, we own certain securities which are classified as short-term investments that we received as a result of a milestone and an upfront license payment as well as 6.0 million shares in Viking.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014, we issued the 2019 Notes with aggregate principal amount of&#160;$245.0 million.&#160;During 2018, $217.7 million in principal of the 2019 Notes were converted and $27.3 million in principal remained outstanding as of December 31, 2018, which will be paid off in cash upon the due date. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2018, we issued the 2023&#160;Notes with an aggregate principal amount of $750.0 million.&#160;A portion of the proceeds from such issuance totaling $49.7 million were used to repurchase 260,000 shares of our common stock.&#160;The 2023 Notes were not convertible as of December 31, 2018.&#160;It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We anticipate that our current cash, cash equivalents, and short-term investments, together with cash provided by operating activities are sufficient to fund our near term capital and operating needs for at least the next 12 months. Operating needs include the planned costs to operate our business, including amounts required to fund working capital and capital expenditures. Our primary short-term needs for capital, which are subject to change, include:</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">potential early repayment of debt obligations as a result of conversions;</span></div><div style="text-indent:18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">repurchases of our outstanding common stock;</span></div><div style="text-indent:18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">the continued advancement of research and development efforts;</span></div><div style="text-indent:18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">potential strategic acquisitions and investments;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> and</span></div><div style="text-indent:18pt;padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8226;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;padding-left:14.5pt;">the expansion needs of our facilities, including costs of leasing additional facilities</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2018, we had $12.5 million in fair value of contingent consideration liabilities associated with prior acquisitions to be settled in future periods.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">During 2018, we used $77.8 million to repurchase 522,248 of our outstanding shares under the stock repurchase programs authorized by our Board of Directors. As of December 31, 2018, there remains $125.2 million under the authorized program.&#160;See </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#8220;Item 5. Market for Registrant's Common Equity, Related Stockholder Matters, and Issuer Purchase of Equity Securities</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#8221;</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Cash Flow Summary</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.391813%;"><tr><td style="width:1.0%;"></td><td style="width:57.435364%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.542942%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.778603%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.542942%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.778603%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.542942%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.778603%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net cash provided by (used in):</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Operating activities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">194,059&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">88,570&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">60,733&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Investing activities</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(423,269)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(79,179)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(134,415)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Financing activities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">328,585&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(7,523)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,994)</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2018, we generated cash from operations, from issuance of the 2023 Notes and associated warrants, and from issuance of common stock under employee stock plans. During the same period we used cash for investing activities, including the acquisition of commercial rights, net purchases of short-term investments, payments made to acquire Vernalis, payments to CVR holders and capital expenditures. We also used cash for financing activities, including principal payments related to</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">40</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> conversions of the 2019 Notes,&#160;payments to purchase the bond hedge associated with the 2023 Notes, payments for taxes related to net share settlement of equity awards and to repurchase shares of our common stock.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2017, we generated cash from operations and from issuance of common stock under employee stock plans. During the same period we used cash for investing activities, including net purchases of short-term investments, payments made to acquire Crystal, payments to CVR holders and capital expenditures. We also used cash to pay taxes related to net share settlement of equity awards and to repurchase shares of our common stock.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2016, we generated cash from operations and from issuance of common stock under employee stock plans.  During the same period we used cash for investing activities, including net purchases of short-term investments, payments made to acquire OMT, commercial license rights from Cormatrix, Viking common stock and shares of an equity method investee, payments to CVR holders and capital expenditures.  We also used cash to pay taxes related to net share settlement of equity awards and to repurchase shares of our common stock.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Off-Balance Sheet Arrangements</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We do not participate in any transactions that generate relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities, which would have been established for the purpose of facilitating off-balance sheet arrangements or other contractually narrow or limited purposes. During the fiscal year ended December 31, 2018, we were not involved in any &#8220;off-balance sheet arrangements&#8221; within the meaning of the rules of the Securities and Exchange Commission.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We lease our office facilities under operating lease arrangements with varying terms through April 2023.  The agreements provide for increases in annual rents based on changes in the Consumer Price Index or fixed percentage increases of 3.0%. We had no off-balance sheet arrangements at December 31, 2018, 2017 and 2016.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Contractual Obligations </span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, future minimum payments due under our contractual obligations are as follows (in thousands):</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"></td><td style="width:32.513274%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.799410%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="27" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments Due by Period</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less&#160;than&#160;1&#160;year</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1-2&#160;years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3-4&#160;years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Thereafter</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Purchase obligations </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,754&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,164&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,590&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Notes payable </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">2</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">803,211&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33,758&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,250&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">758,203&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Operating lease obligations </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">3</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,963&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,620&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,145&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:-27pt;padding-left:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;&#160;(1) &#160;Amounts represent our commitments under our supply agreement with Hovione for Captisol purchases.</span></div><div style="text-indent:-27pt;padding-left:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;(2) &#160;Amounts represent contractual amounts due under our convertible senior notes, including interest based on the fixed rate of 0.75% per year.</span></div><div style="text-indent:-27pt;padding-left:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#160;(3) &#160;We lease an office and research facility, which we have fully vacated under operating lease arrangements expiring on June 2019. We sublet these facilities through the end of our lease. As of December&#160;31, 2018, we expect to receive aggregate future minimum lease payments totaling $0.4 million (non-discounted) over the duration of the sublease agreement, which are not included in the table above.&#160;</span></div><div style="text-indent:36pt;"><span><br/></span></div><div id="i_0_197"></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Critical Accounting Policies and Estimates</span></div><div style="text-indent:24pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preparation of financial statements in conformity with&#160;GAAP requires estimates and assumptions that affect the reported amounts of assets and liabilities, revenues and expenses, and related disclosures of contingent liabilities in the consolidated financial statements and accompanying notes. The SEC has defined a company&#8217;s critical accounting policies as the ones that are most important to the portrayal of the company&#8217;s financial condition and results of operations, and which require the company to make its most difficult and subjective judgments, often as a result of the need to make estimates of matters that are inherently uncertain. Based on this definition, we have identified the critical accounting policies and judgments addressed below. We also have other key accounting policies, which involve the use of estimates, judgments, and assumptions that are significant to understanding our results. For additional information, see &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (1), Basis of Presentation and Summary of Significant Accounting Policies</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#8221; Although we believe that our estimates, assumptions, and judgments are reasonable, they are based upon information presently available. Actual results may differ significantly from these estimates under different assumptions, judgments, or conditions.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">41</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Revenue Recognition</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 1, 2018, we adopted ASC 606, which amends the guidance for recognition of revenue from contracts with customers using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. We apply the following five-stop model in order to determine the revenue: (i) identification of&#160;the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations, including whether</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of&#160;the transaction price to the performance obligations; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own under the contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment. These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Revenue from material sales is recognized when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">We occasionally have sub-license obligations related to arrangements for which we receive license fees, milestones and royalties. We evaluate the determination of gross as a principal versus net as an agent reporting based on each individual agreement.</span></div><div style="text-indent:27pt;margin-top:9pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Intangible Assets and Other Long-Lived Assets &#8212; Impairment Assessments</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We regularly perform reviews to determine if the carrying values of our long-lived assets are impaired. A review of identifiable intangible assets and other long-lived assets is performed when an event occurs indicating the potential for impairment. If indicators of impairment exist, we first assess the impairment evaluation and then assess the recoverability of the affected long-lived assets and compare their fair values to the respective carrying amounts if needed. An impairment evaluation</span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">42</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> is based on an undiscounted cash flow analysis at the lowest level at which cash flows of the long-lived assets are largely independent of other groups of assets and liabilities.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In order to estimate the fair value of identifiable intangible assets and other long-lived assets, we estimate the present value of future cash flows from those assets. The key assumptions that we use in our discounted cash flow model are the amount and timing of estimated future cash flows to be generated by the asset over an extended period of time and a rate of return that considers the relative risk of achieving the cash flows, the time value of money, and other factors that a willing market participant would consider. Significant judgment is required to estimate the amount and timing of future cash flows and the relative risk of achieving those cash flows. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Assumptions and estimates about future values and remaining useful lives are complex and often subjective. They can be affected by a variety of factors, including external factors such as industry and economic trends, and internal factors such as changes in our business strategy and our internal forecasts. For example, if our future operating results do not meet current forecasts or if we experience a sustained decline in our market capitalization that is determined to be indicative of a reduction in fair value of our reporting unit, we may be required to record future impairment charges for purchased intangible assets. Impairment charges could materially decrease our future net income and result in lower asset values on our balance sheet.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Contingent Liabilities</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In October 2017, we acquired Crystal for total cash consideration of&#160;$27.2 million, plus contingent consideration of up to an additional&#160;$10.5 million&#160;over a&#160;five year period following the acquisition date based on certain research milestones and a portion of the payments that we receive from a specified part of the historical Crystal business. The&#160;contingent consideration&#160;is measured at fair value using an income approach valuation technique, specifically with&#160;probability&#160;weighted&#160;and discounted cash flows. The fair value of the liability is assessed at each reporting date and the change in fair value is recorded in our consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. The fair value of the&#160;contingent&#160;consideration liability&#160;as of&#160;December&#160;31, 2018&#160;was $8.4 million.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with our acquisition of CyDex in January 2011, we recorded contingent liabilities for amounts potentially due to holders of the CyDex CVRs and certain other contingency payments. The fair value of the liability is assessed at each reporting date using the income approach incorporating the estimated future cash flows from potential milestones and revenue sharing. The change in fair value is recorded in our consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as proceeds are received by us from the sale or partnering of any of the Metabasis drug development programs. The fair values of the CVRs are remeasured at each reporting date through the term of the related agreement. Changes in the fair values are reported in the statement of operations as income (decreases) or expense (increases). The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;margin-bottom:10pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">See additional information in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (4), Fair Value Measurement.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income Taxes   </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#160;</span></div><div style="text-indent:27pt;margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our provision for income taxes, deferred tax assets and liabilities, and reserves for unrecognized tax benefits reflect our best assessment of estimated future taxes to be paid. Significant judgments and estimates based on interpretations of existing tax laws or regulations in the United States are required in determining our provision for income taxes. Changes in tax laws, statutory tax rates, and estimates of our future taxable income could impact the deferred tax assets and liabilities provided for in the consolidated financial statements and would require an adjustment to the provision for income taxes. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating our ability to recover deferred tax assets within the jurisdiction which they arise, we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, our history of earnings and reliability of our forecasts, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">43</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize the impact of a tax position in our financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Tax authorities regularly examine our returns in the jurisdictions in which we do business and we regularly assess the tax risk of our return filing positions. Due to the complexity of some of the uncertainties, the ultimate resolution may result in payments that are materially different from our current estimate of the tax liability. These differences, as well as any interest and penalties, will be reflected in the provision for income taxes in the period in which they are determined.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Recent Accounting Pronouncements</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">For the summary of recent accounting pronouncements applicable to our consolidated financial statements, see &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (1), Basis of Presentation and Summary of Significant Accounting Policies.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div id="i_0_209"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;7A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Quantitative and Qualitative Disclosures About Market Risk</span></td></tr></table></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We are exposed to market risk from interest rates and equity prices which could affect our results of operations, financial condition and cash flows. We manage our exposure to these market risks through our regular operating and financing activities.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Investment Portfolio Risk</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At December&#160;31, 2018, our investment portfolio included investments in available-for-sale equity securities of&#160;$601.2 million and investment in Viking common stock of&#160;$46.2 million&#160;. These securities are subject to market risk and may decline in value based on market conditions.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Equity Price Risk</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our 2019 Notes include conversion and settlement provisions that are based on the price of our common stock at conversion or maturity of the notes, as applicable. The minimum amount of cash we may be required to pay is $245.0 million, but will ultimately be determined by the price of our common stock. The fair values of our 2019 Notes are dependent on the price and volatility of our common stock and will generally increase or decrease as the market price of our common stock changes. In order to minimize the impact of potential dilution to our common stock upon the conversion of the 2019 Notes, we entered into convertible bond hedges covering&#160;3,264,643&#160;shares of our common stock. Concurrently with entering into the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants with an exercise price of approximately $125.08 per share, subject to adjustment. During 2018, we received notices for conversion of $217.7 million, which were all settled as of December 31, 2018. Throughout the term of the 2019 Notes, the notes may have a dilutive effect on our earnings per share to the extent the stock price exceeds the conversion price of the notes. Additionally, the warrants may have a dilutive effect on our earnings per share to the extent the stock price exceeds the strike price of the warrants.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our 2023&#160;Notes include conversion and settlement provisions that are based on the price of our common stock at conversion or maturity of the notes, as applicable.&#160;As of December 31, 2018, the &#8220;if-converted value&#8221; did not exceed the principal amount of the 2023 Notes. See detail in&#160;&#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (6), Convertible Senior Notes.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Foreign Currency Risk</span></div><div><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Through our licensing and business operations, together with our recent acquisition of Vernalis, we are exposed to foreign currency risk. Foreign currency exposures arise from transactions denominated in a currency other than the functional currency and from foreign denominated revenues and profit translated into U.S. dollars. Our license partners sell our products worldwide in currencies other than the U.S. dollar. Because of this, our revenues from royalty payments are subject to risk from changes in exchange rates. </span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We purchase Captisol from Hovione, located in Lisbon, Portugal. Payments to Hovione are denominated and paid in U.S. dollars; however, the unit price of Captisol contains an adjustment factor which is based on the sharing of foreign currency risk between the two parties. The effect of an immediate 10% change in foreign exchange rates would not have a material impact on our financial condition, results of operations or cash flows. We do not currently hedge our exposures to foreign currency fluctuations.</span></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">44</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Interest Rate Risk</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We are exposed to market risk involving rising interest rates. To the extent interest rates rise, our interest costs could increase. An increase in interest costs of 10% would not have a material impact on our financial condition, results of operations or cash flows.</span></div><div style="text-indent:24pt;margin-top:9pt;"><span><br/></span></div><div id="i_0_221"></div><div><span><br/></span></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">45</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;8.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Consolidated Financial Statements and Supplementary Data</span></td></tr></table></div><div><span><br/></span></div><div><span><br/></span></div><div id="i_0_233"></div><div style="text-align:center;margin-top:9pt;"><span><br/></span></div><div style="text-align:center;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">INDEX TO CONSOLIDATED FINANCIAL STATEMENTS</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:93.161290%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:2.838710%;"></td><td style="width:0.1%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Page</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_245">Report</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_245"> of Independent Registered Public Accounting Firm</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_245">47</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_271">Consolidated Balance Sheets</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_271">48</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_297">Consolidated Statements of Operations</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_297">49</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_309">Consolidated Statements of Comprehensive Income (Loss)</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_309">50</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_321">Consolidated Statements of Stockholders&#8217; Equity</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_321">52</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_334">Consolidated Statements of Cash Flows</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_334">52</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_346">Notes to Consolidated Financial Statements</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_346">54</a></span></div></td></tr></table></div><div><span><br/></span></div><div id="i_0_245"></div><div style="text-indent:36pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">46</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Report of Independent Registered Public Accounting Firm</span></div><div style="text-align:justify;margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Board of Directors and Stockholders of Ligand Pharmaceuticals Incorporated</span></div><div style="text-align:justify;margin-top:18pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Opinion on the Financial Statements</span></div><div style="text-indent:36pt;text-align:justify;margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have audited the accompanying consolidated balance sheets of Ligand Pharmaceuticals Incorporated  (the Company) as of December 31, 2018 and 2017, the related consolidated statements of operations, comprehensive income (loss), stockholders&#8216; equity and cash flows for each of the three years in the period ended December 31, 2018, and the related notes (collectively referred to as the &#8220;consolidated financial statements&#8221;). In our opinion, the consolidated financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2018 and 2017, and the results of its operations and its cash flows for each of the three years in the period ended December 31, 2018, in conformity with U.S. generally accepted accounting principles.</span></div><div style="text-indent:36pt;text-align:justify;"><span><br/></span></div><div style="text-indent:36pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the Company&#8217;s internal control over financial reporting as of December 31, 2018, based on criteria established in Internal Control-Integrated Framework&#160;issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 Framework), and our report dated February&#160;28, 2019 expressed an unqualified opinion thereon.</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:115%;">Adoption of ASU No. 2014-09</span></div><div><span><br/></span></div><div style="text-indent:36pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">As discussed in Note 1 to the consolidated financial statements, the Company changed its method of accounting for recognizing revenue due to the adoption of Accounting Standards Update (ASU) 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10, and 2016-12, effective January 1, 2018. </span></div><div><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:114%;">Adoption of ASU No. 2016-01</span></div><div><span><br/></span></div><div style="text-indent:36pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">As discussed in Note 1 to the consolidated financial statements, the Company changed its method of accounting for financial instruments due to the adoption of Accounting Standards Update (ASU) 2016-01, Financial Instruments- Recognition and Measurement of Financial Assets and Financial Liabilities, effective January 1, 2018. </span></div><div><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:113%;">Adoption of ASU No. 2016-09</span></div><div><span><br/></span></div><div style="text-indent:36pt;text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:113%;">As discussed in Note 1 to the consolidated financial statements, the Company changed its method of accounting for share-based payment transactions in 2017 due to the adoption of the amendments to the FASB Accounting Standards Codification resulting from Accounting Standards Update (ASU) No. 2016-09, Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting, effective January 1, 2017. </span></div><div style="text-indent:36pt;text-align:justify;"><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Basis for Opinion</span></div><div style="text-indent:36pt;text-align:justify;margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">These financial statements are the responsibility of the Company&#8217;s management. Our responsibility is to express an opinion on the Company&#8216;s financial statements based on our audits.&#160;We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB. </span></div><div style="text-indent:36pt;text-align:justify;margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We conducted our audits in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement, whether due to error or fraud. Our audits included performing procedures to assess the risks of material misstatement of the financial statements, whether due to error or fraud, and performing procedures that respond to those risks. Such procedures included examining, on a test basis, evidence regarding the amounts and disclosures in the financial statements. Our audits also included evaluating the accounting principles used and significant estimates made by management, as well as evaluating the overall presentation of the financial statements. We believe that our audits provide a reasonable basis for our opinion.</span></div><div style="text-indent:252pt;margin-top:6pt;"><span><br/></span></div><div style="text-indent:252pt;margin-top:6pt;"><span><br/></span></div><div style="text-indent:252pt;margin-top:6pt;"><span><br/></span></div><div style="text-indent:252pt;margin-top:6pt;"><span><br/></span></div><div style="margin-top:6pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">47</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">/s/ Ernst&#160;&amp; Young&#160;LLP</span></div><div style="text-align:justify;margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have served as the Company&#8216;s auditor since 2016.</span></div><div style="text-align:justify;"><span><br/></span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">San Diego, California</span></div><div style="text-align:justify;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</span></div><div><span><br/></span></div><div><span><br/></span></div><div id="i_0_271"></div><div style="text-indent:36pt;text-align:center;"><span><br/></span></div><div style="text-indent:36pt;text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">48</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:36pt;text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">CONSOLIDATED BALANCE SHEETS</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(in thousands, except share data)</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:72.008811%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">ASSETS</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current assets:</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Cash and cash equivalents </span></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashAndCashEquivalentsAtCarryingValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQtMS0xLTEtMA_adefee13-5bb6-4c01-a290-257d06784da9">117,164</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashAndCashEquivalentsAtCarryingValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQtMy0xLTEtMA_c7ee5f7c-67de-4af7-bc99-614adc15c5f2">20,620</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzUtMS0xLTEtMA_b623dad8-7d48-45ff-a40c-0386715f2715">601,217</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzUtMy0xLTEtMA_e1231891-e06f-45b6-abc1-90bf3337b36f">181,041</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:EquitySecuritiesFvNi" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMS0xLTEtMTUyNTg_6c406f9e-1221-430f-a569-76784fc52117">46,191</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:EquitySecuritiesFvNi" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMy0xLTEtMTUyNDg_46fd28ea-a9c1-4b8c-98af-6be52d9992cf">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts receivable, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ReceivablesNetCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMS0xLTEtMA_423f4201-a19d-458a-88a3-7be619a5f686">55,850</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ReceivablesNetCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMy0xLTEtMA_e3ffe6ae-8245-4594-97e6-d386bfc761c9">25,596</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Note receivable from Viking </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:NotesAndLoansReceivableGrossCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzctMS0xLTEtMA_6a3d2301-cbaf-4344-a10a-d7358932fb19">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NotesAndLoansReceivableGrossCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzctMy0xLTEtMA_f12346f1-042d-46ba-b165-101c44ef2eb7">3,877</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inventory</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InventoryNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzgtMS0xLTEtMA_84327058-f936-44e5-8300-dfc80a354bf3">7,124</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InventoryNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzgtMy0xLTEtMA_9dc62853-130f-4ba7-9a3c-15eba8b4a984">4,373</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Derivative asset</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DerivativeAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMS0xLTEtMTMyNg_12291bca-9d33-4663-b5a8-90816e3e1c88">22,576</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DerivativeAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMTMyOA_2cbc21fe-77a2-4abc-9aa2-be2851b40909"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DerivativeAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMTMyOA_7533d16c-789e-4f51-8df8-a821eddac2c5">&#8212;</ix:nonFraction></ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMS0xLTEtMA_c7da0178-7c95-4ba4-b023-cf643ee72e47">20,418</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMA_06ee93ec-b8a5-4868-b9d3-1f4653f68cbf">1,514</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEwLTEtMS0xLTA_999226cb-e229-4bb4-8576-b42bff6f071a">870,540</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEwLTMtMS0xLTA_58f0cb25-ed28-4c15-b0ae-5ffd2b6358ed">237,021</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred income taxes, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredIncomeTaxAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzExLTEtMS0xLTA_1fc0b6ad-1b07-4c0e-9d3f-26a6605d528c">46,521</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredIncomeTaxAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzExLTMtMS0xLTA_646302e6-3558-4b82-80a3-f389064cb133">84,422</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:EquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEyLTEtMS0xLTA_3a9b8022-bd57-4a7a-b956-a55a74f53c1e">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:EquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEyLTMtMS0xLTA_d0ae4409-3fe3-49c0-a137-17d43795131f">6,438</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Intangible assets, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IntangibleAssetsNetExcludingGoodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEzLTEtMS0xLTA_329972b9-349c-449c-b397-e305bb709174">219,793</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IntangibleAssetsNetExcludingGoodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEzLTMtMS0xLTA_fab1a804-64d8-4d9b-8ee8-5482c38f0ab9">228,584</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE0LTEtMS0xLTA_b9691fe3-11c3-4ce3-9ea7-ed45dc90a7ca">86,646</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE0LTMtMS0xLTA_167f4bb4-6490-4a32-a0ec-1cd08a7f9b2b">85,959</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Commercial license rights</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:CommercialLicenseRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE1LTEtMS0xLTA_1f836af7-0c9d-49b2-88cf-88153c652598">31,460</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:CommercialLicenseRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE1LTMtMS0xLTA_2fac83db-bf13-43c0-b40a-d85e61f44be0">19,526</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Property and equipment, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE2LTEtMS0xLTA_b030c8a8-3bd7-470c-a075-c60d9de283a8">5,372</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE2LTMtMS0xLTA_b029a0a0-dcbb-40f4-aabd-758dc1b4f003">4,212</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:OtherAssetsNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE3LTEtMS0xLTA_b4cd128c-f8d0-4109-975f-0d472b6dd033">471</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAssetsNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE3LTMtMS0xLTA_20f17531-4baf-469c-8753-b6aa5ea0b654">4,859</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Assets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE4LTEtMS0xLTA_eda5ad33-9f69-4ae1-bff0-0635044a21f6">1,260,803</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Assets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE4LTMtMS0xLTA_f04d3ccd-57cd-4604-b4bc-b8b0d984a5c7">671,021</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LIABILITIES AND STOCKHOLDERS&#8217; EQUITY </span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current liabilities:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccountsPayableCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIxLTEtMS0xLTA_1802ef8b-a847-48c8-915d-c8e1be34f0a0">4,183</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccountsPayableCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIxLTMtMS0xLTA_919cd12d-f47b-49fb-bcc5-40a0d14465eb">2,259</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accrued liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIyLTEtMS0xLTA_438f8fc7-81b3-4570-9435-da2d14b0a6e6">19,200</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIyLTMtMS0xLTA_677582e2-63fc-4155-959a-7851a89793e0">7,377</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:CurrentPortionOfLiabilityForContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIzLTEtMS0xLTA_0f0b5c88-1261-4107-b1f0-5ee4277fa575">5,717</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:CurrentPortionOfLiabilityForContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIzLTMtMS0xLTA_e44c62ca-0a61-4184-8c87-3e4aa402e1e5">4,703</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">      Deferred revenue   &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ContractWithCustomerLiabilityCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTEtMS0xLTEzMDc_17c46a1e-05a3-48b4-ac81-4803d5e65995">3,286</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:ContractWithCustomerLiabilityCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTMtMS0xLTc3MDY_58d8118f-02c5-4c71-b2dc-651d2d5ee275">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">      Derivative liability&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DerivativeLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTEtMS0xLTEzMTE_fbaa28dd-c2b3-4854-b949-eb59e4ab1077">23,430</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DerivativeLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTMtMS0xLTc3MDg_284033eb-665f-4d1b-b1fb-605fa2e698ee">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">2019 convertible senior notes, net</span></div><div style="text-indent:12pt;"><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ConvertibleDebtCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTEtMS0xLTA_9aab049b-f22f-4f8a-b2a1-3bcdf4b91dd8">26,433</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ConvertibleDebtCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTMtMS0xLTA_b1d8a999-a860-4773-8c67-f91ba5ca13e6">224,529</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total current liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTEtMS0xLTA_5df9c664-fbc7-48d6-9b82-948ee1032c9e">82,249</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTMtMS0xLTA_cfffe437-fd76-464b-9c1d-aff66e054ccc">238,868</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2023 convertible senior notes, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ConvertibleDebtNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTEtMS0xLTEyOTc_58b34d35-d3b0-4dce-949b-b14bd522f476">609,864</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:ConvertibleDebtNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTMtMS0xLTc3MTA_3279b4db-64b9-4864-8585-2ddf78c941cf">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Long-term contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:LiabilityForContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTEtMS0xLTA_6e817c8d-9500-42ae-9273-6fd025b6af59">6,825</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:LiabilityForContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTMtMS0xLTA_d7a642d4-827f-4a7f-af76-3c65309012ca">9,258</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other long-term liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:OtherLiabilitiesNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI4LTEtMS0xLTA_aa40bb3c-e399-44d6-95c6-a2694846c321">951</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherLiabilitiesNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI4LTMtMS0xLTA_5cb4dca2-e66a-4f56-ac7b-7accb62855cb">4,248</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Liabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTEtMS0xLTA_2ff869dc-061f-4b69-985f-8c7fa45a9b4c">699,889</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Liabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTMtMS0xLTA_20a718cf-c288-4aff-a61a-3a7f55fbc0b8">252,374</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Commitments and contingencies</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" xsi:nil="true" name="us-gaap:CommitmentsAndContingencies" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMwLTEtMS0xLTA_bd6a64a3-d61e-4d8e-90b8-8fa9095a811d"></ix:nonFraction></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" xsi:nil="true" name="us-gaap:CommitmentsAndContingencies" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMwLTMtMS0xLTA_a8a8d6f2-8535-4a42-b7db-ab70a161c2aa"></ix:nonFraction></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Equity component of currently redeemable convertible notes (Note 6)</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMxLTEtMS0xLTA_d7ea5d61-1a58-4ef3-9c74-5c1f6219e1d6">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMxLTMtMS0xLTA_407f035d-5f00-4d96-b30f-d28d1b6e872d">18,859</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Stockholders&#8217; equity:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Common stock, $0.001 par value; 60,000,000 and 33,333,333 shares authorized; 20,765,533 and 21,148,665 shares issued and outstanding at December&#160;31, 2018 and 2017, respectively</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:CommonStockValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMzLTEtMS0xLTA_e938d5a8-8216-459b-a9e9-562e5e3630d8">21</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:CommonStockValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMzLTMtMS0xLTA_27b61699-4718-48b7-aaae-b9a1ed252a89">21</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Additional paid-in capital</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdditionalPaidInCapital" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM0LTEtMS0xLTA_91b776b4-61a3-445d-a9cf-3ce5b8d068e9">791,114</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdditionalPaidInCapital" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM0LTMtMS0xLTA_f73c68d4-c7df-4497-a3d3-b3edaebe6f71">798,205</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accumulated other comprehensive income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM1LTEtMS0xLTA_b0080c34-8f4d-43d4-b203-3b14e466f5c6">1,024</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM1LTMtMS0xLTA_3c431476-5e19-4da6-aa8f-f165c97629f1">2,486</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accumulated deficit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:RetainedEarningsAccumulatedDeficit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM2LTEtMS0xLTA_66fae316-4228-4acd-bb1e-4fcb8fa34b44">229,197</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:RetainedEarningsAccumulatedDeficit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM2LTMtMS0xLTA_cc05fca6-20c7-4058-8ac9-e2f9299c5142">400,924</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total stockholders&#8217; equity</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM3LTEtMS0xLTA_9eb797ae-549d-4b1a-8775-c2c17049fbc9">560,914</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM3LTMtMS0xLTA_ba411127-335e-456e-bc06-3efbab460702">399,788</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total liabilities and stockholders&#8217; equity </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesAndStockholdersEquity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQwLTEtMS0xLTA_eef810f7-a17b-4cf6-8f95-6b69aaaec022">1,260,803</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesAndStockholdersEquity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQwLTMtMS0xLTA_ca8e8ae8-a542-4113-9e79-9c9496645b1c">671,021</ix:nonFraction>&#160;</span></td></tr></table></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">See accompanying notes to these consolidated financial statements.</span></div><div id="i_0_297"></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">49</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">CONSOLIDATED STATEMENTS OF OPERATIONS</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(in thousands, except per share amounts)</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:61.823529%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.764706%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.470588%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.470588%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Revenues:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtMS0xLTEtMA_60e8fd47-b9cb-4b97-a668-3bc1a1724708">128,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id52ed0969c704d12ac017e1b160c1fed_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtMy0xLTEtMA_3a0469f6-96bf-40f8-876e-ac71ded18c58">88,685</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i47f87ffe68104f86a60d18b2b37e6cf3_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtNS0xLTEtMA_5466c407-1ce9-4b7f-a6ab-086ef0401b08">59,423</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material sales</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtMS0xLTEtMA_ff639fdb-dea3-4038-91c9-1562e0bd3483">29,123</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtMy0xLTEtMA_229b5fb8-7eef-4caf-8412-617f341dad6c">22,070</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtNS0xLTEtMA_f431835d-1c44-4fea-97c9-f4d126afa0f7">22,502</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones and other revenues</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtMS0xLTEtMA_b8df8e9e-8d7c-464b-bb25-b4080bc2e391">93,774</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtMy0xLTEtMA_1b5aa757-0222-4b21-8b6c-8ca2af42dd99">30,347</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i827aa32e6966431f90040e4f23139fce_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtNS0xLTEtMA_6ac8c4d5-004b-4033-8681-fdb9e140260f">27,048</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtMS0xLTEtMA_7f9bc803-d267-4c26-a31e-96790fa8d6b6">251,453</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtMy0xLTEtMA_1841e03d-6e06-485a-9887-f7726e0ab7c2">141,102</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtNS0xLTEtMA_1e9d8c27-279a-4ef5-83a1-322b25cf96c4">108,973</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Operating costs and expenses:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Cost of material sales</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSold" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtMS0xLTEtMA_4f6d0eaa-7171-4b69-8762-83e7f515072c">6,337</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSold" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtMy0xLTEtMA_46a9e05f-3aa3-48d2-a2ca-e5c16743e8f1">5,366</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSold" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtNS0xLTEtMA_7b78f9a4-1ef7-44d4-a8f0-2fb49ae951ff">5,571</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amortization of intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSoldAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktMS0xLTEtMA_17f6b579-9f39-4cf9-a234-eb723d597b8c">15,792</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSoldAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktMy0xLTEtMA_c3cb1454-64f5-49aa-8f8a-9845bcff3c9d">12,120</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CostOfGoodsAndServicesSoldAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktNS0xLTEtMA_91ece387-2d1e-47f6-b8bd-b85020c93991">10,643</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ResearchAndDevelopmentExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTEtMS0xLTA_a38a3e7c-ed00-46e6-9d77-085e46359ee4">27,863</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ResearchAndDevelopmentExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTMtMS0xLTA_87b89b0b-2cc5-4b5f-9d25-58ae5484db2b">26,887</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ResearchAndDevelopmentExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTUtMS0xLTA_732efccf-8eb0-4d76-89ab-3e185011b6cf">21,221</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:GeneralAndAdministrativeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTEtMS0xLTA_89a561b0-7eda-4c5b-89ef-0583b77a5693">37,734</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:GeneralAndAdministrativeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTMtMS0xLTA_06ca60de-7fb6-4460-978d-2e3ee419b440">28,653</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:GeneralAndAdministrativeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTUtMS0xLTA_f6be5995-d2a2-4219-9c88-26ea853f163b">27,653</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTEtMS0xLTA_28f18039-d0b5-48ef-8df7-650a4611a5a9">87,726</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTMtMS0xLTA_61a82c9b-e443-409f-9005-162c34ea85c0">73,026</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTUtMS0xLTA_e410344d-20ad-46cc-a419-9c99ac254388">65,088</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income from operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTEtMS0xLTA_2243966d-1e79-42e8-abc0-de4fbb1e15e0">163,727</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTMtMS0xLTA_2330e48f-dc67-4696-b295-01874712defb">68,076</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTUtMS0xLTA_ecbf1fec-a036-4394-8b0a-24c82366efce">43,885</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other income (expense):</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gain (loss) from Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:EquitySecuritiesFvNiGainLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTEtMS0xLTA_aeac06b1-3631-42c2-9d1d-82f8dae66af1">50,187</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:EquitySecuritiesFvNiGainLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTMtMS0xLTA_172ad412-6354-426a-9448-3d9aa64176fd">2,048</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:EquitySecuritiesFvNiGainLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTUtMS0xLTA_c2e03bca-269d-414e-ac82-269cc436e269">23,132</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest income</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InvestmentIncomeNonoperating" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTEtMS0xLTA_3da565f5-5504-43b6-8eaf-e3c01a989ce8">13,999</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InvestmentIncomeNonoperating" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTMtMS0xLTA_be54a2c1-29b3-4e96-941c-01d8a022079b">2,060</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:InvestmentIncomeNonoperating" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTUtMS0xLTA_0d18a8f7-9bda-4ded-b133-abc2ee774f96">664</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTEtMS0xLTA_065dc91c-14f9-4558-a878-79d4537cde63">48,276</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTMtMS0xLTA_858f9ff4-87f2-4967-8381-92b990032077">13,460</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTUtMS0xLTA_8fd8b64b-f13d-41a1-a611-7df397eec250">12,842</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other income (expense), net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:OtherNonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTEtMS0xLTA_5cf7a19b-cbae-452f-971d-54a5f3e68803">6,307</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherNonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTMtMS0xLTA_3bacac38-5c48-437e-b37a-49e354ba805d">2,603</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:OtherNonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTUtMS0xLTA_6bba7ff0-573e-451f-bccb-e7c843895e9f">615</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total other income (expense), net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTEtMS0xLTc3MTY_0d27ca0a-7c06-4c31-b63d-5eec10e4a593">9,603</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTMtMS0xLTc3MTQ_8d902056-1b07-4d29-9653-a984803a6224">10,845</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NonoperatingIncomeExpense" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTUtMS0xLTc3MTI_cb91bdc5-0e51-4bc5-8c4c-6b2962097533">35,925</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income before income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTEtMS0xLTc3MTg_a7eb3f7c-d19b-4c7e-b37e-f425394a755d">173,330</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTMtMS0xLTc3MjA_9d264970-40c1-4f11-b2de-6a77d879c62e">57,231</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTUtMS0xLTc3MjI_724ac07d-052e-4bec-a00d-27c3805caafd">7,960</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTEtMS0xLTA_2013c6bb-2553-4f93-a07e-082e4d9839d8">30,009</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTMtMS0xLTA_51257573-1878-4b06-9f9e-4cfc524cf37f">44,675</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTUtMS0xLTA_84011968-3aa3-48bc-89dd-bd048b6fdeda">10,327</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTEtMS0xLTA_67f323ec-19f3-4ed3-863d-bf3a3f878dd7">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTMtMS0xLTA_ba7fa0a5-9ef1-499b-980e-4ace8cc54d06">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTUtMS0xLTA_a8eddc8a-d1ee-4bf4-a3d9-58ca8a483372">2,367</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Discontinued operations:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gain on sale of Oncology Product Line before income taxes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTEtMS0xLTA_9f671275-6612-418e-b0c8-a73376edf5f1">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTMtMS0xLTA_e0c7b96c-b471-4b91-9bb7-035fd968dbd6">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTUtMS0xLTA_28c6d95b-46bf-4752-8cbf-9654f58b5da0">1,139</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense on discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTEtMS0xLTA_3a002461-b4d0-4b9c-ab1b-7e8e0576c3ae">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTMtMS0xLTA_8f311c3a-5383-467b-8bd7-c18cc8e43138">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTUtMS0xLTA_5bdaad16-b485-4f1f-b6ba-1ca5629338ab">408</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">      Income from discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTEtMS0xLTA_a4e857b5-b109-481c-b04e-2929865180b7">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTMtMS0xLTA_ac2e91f2-9d98-4c1e-aa3a-beb0beb5ac2b">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTUtMS0xLTA_8650ac70-3d7a-4263-979c-4287ec7e2056">731</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss):</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTEtMS0xLTA_21314f3a-c7db-4a49-8711-015eae804810">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTMtMS0xLTA_40d8b174-343e-41f5-9073-42eed2cee6bf">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTUtMS0xLTA_d1aef6df-bc51-4cf7-b116-ff229dfaeb31">1,636</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:6pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">      Basic per share amounts</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:5.2pt;font-weight:400;line-height:100%;vertical-align:top;">(1)</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">:</span></div></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Income (loss) from continuing operations</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:IncomeLossFromContinuingOperationsPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424">6.77</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" name="us-gaap:IncomeLossFromContinuingOperationsPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0">0.60</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" sign="-" name="us-gaap:IncomeLossFromContinuingOperationsPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6">0.11</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Income from discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" format="ixt:zerodash" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" format="ixt:zerodash" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb">0.04</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988">6.77</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0">0.60</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" sign="-" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668">0.08</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">      Diluted per share amounts</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:5.2pt;font-weight:400;line-height:100%;vertical-align:top;">(1)</sup><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">:</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">    Income (loss) from continuing operations</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8">5.96</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" name="us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648">0.53</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" sign="-" name="us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658">0.11</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">    Income from discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" format="ixt:zerodash" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" format="ixt:zerodash" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" name="us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6">0.04</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1">5.96</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a">0.53</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="2" sign="-" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a">0.08</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average common shares outstanding: </span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTEtMS0xLTA_eacb2c3a-f19d-47f9-bbf1-14763368636a">21,160</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTMtMS0xLTA_66294cc1-4c08-4116-9987-df230a8839a8">21,032</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTUtMS0xLTA_853c5ca3-6830-4dc7-8a16-e6479a4abe44">20,831</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTEtMS0xLTA_da2c18b8-a406-4637-94cf-79e8eef5b081">24,067</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTMtMS0xLTA_97e9ab14-d25d-46cc-ab29-a65cc918cf45">23,481</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTUtMS0xLTA_ae8fdbfe-28ad-4e35-9be2-a5cefaa461bd">20,831</ix:nonFraction>&#160;</span></td></tr></table></div><div style="margin-top:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">(1) <ix:footnote id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62" xml:lang="en-US" footnoteRole="http://www.xbrl.org/2003/role/footnote">The sum of net income per share amounts may not equal the total due to rounding</ix:footnote></span></div><div style="margin-top:3pt;"><span><br/></span></div><div style="text-align:center;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">See accompanying notes to these consolidated financial statements.</span></div><div id="i_0_309"></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">50</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">&#160;CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(in thousands</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">)</span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:66.281938%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.719530%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.719530%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:6.810573%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December 31, </span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItMS0xLTEtMA_68457d23-7a74-4c49-aa9e-808c9df2a44d">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItMy0xLTEtMA_cfaa18d6-3799-4141-aa0d-9cf06de387de">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItNS0xLTEtMA_2b68343f-f555-4eb4-a204-bb18ebda6398">1,636</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unrealized net gain on available-for-sale securities, net of tax</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtMS0xLTEtMA_8720599b-b6a5-42f1-a90c-44d636945e8e">73</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtMy0xLTEtMA_d1cd2295-bfca-4295-bd7f-c41144209db6">143</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtNS0xLTEtMA_4b467b78-508b-4c28-8c1b-9bf5cd7d7273">93</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign currency translation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMS0xLTEtMTUxNDg_5f74390a-162b-4b7f-8f35-e6e633694f04">921</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMy0xLTEtMTUxMjY_f157f695-d877-402c-a314-f31a0e02473f">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtNS0xLTEtMTUxMjk_39bf010e-0a5a-43cc-9135-4c9f8753b3bd">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Less: Reclassification of net realized gains included in net income (loss), net of tax</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMS0xLTEtMA_566991df-e613-4d6f-8ced-a9dccb29b54a">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMy0xLTEtMA_f7039268-8ee4-4f37-88f8-45d340357738">400</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtNS0xLTEtMA_5be10962-2a29-49ae-8c6a-2a556ee313b5">2,253</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Comprehensive income (loss) </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ComprehensiveIncomeNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtMS0xLTEtMA_f2cbed16-6138-4570-a4c0-c63ce6bc2e2e">142,473</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ComprehensiveIncomeNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtMy0xLTEtMA_f7fde87c-eff4-47c5-b739-3f1ef6ad0246">12,299</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:ComprehensiveIncomeNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtNS0xLTEtMA_c7de54f7-aec2-4037-a017-4aaf7b320e9a">3,796</ix:nonFraction>)</span></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">See accompanying notes to these consolidated financial statements.</span></div><div><span><br/></span></div><div id="i_0_321"></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">51</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">CONSOLIDATED STATEMENT OF STOCKHOLDERS&#8217; EQUITY </span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(in thousands, except share data)</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:32.356725%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.087719%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:4.432749%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.403509%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.210526%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.087719%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:0.1%;"></td><td style="width:0.530994%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.035088%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:6.5pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common Stock</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">Additional</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">paid-in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">capital</span></div></td><td colspan="3" rowspan="2" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">Accumulated</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">comprehensive</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">income (loss)</span></div></td><td colspan="3" rowspan="2" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">Accumulated</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">deficit</span></div></td><td colspan="3" rowspan="2" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;height:21pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">Total</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">stockholders&#8217;</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:700;line-height:100%;">equity</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:6.5pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:6.5pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amount</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at January 1, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if12b4d59cd2641ccb993432a96845435_I20151231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:SharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEtMS0xLTA_f50b5068-09e2-48e2-9e53-c9f7e74bd65c">19,949,012</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if12b4d59cd2641ccb993432a96845435_I20151231" decimals="-3" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTMtMS0xLTA_3f7d7a88-2cb9-44a6-9085-04620e328175">20</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia9cbdd5a3f014dbfba8949b4362c8099_I20151231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTUtMS0xLTA_45077b4f-fa82-4507-b4e1-6cccae1697c5">661,850</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ied16ee55eeae4367832c19a676fd4c62_I20151231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTctMS0xLTA_1df8dd99-b2f0-4c26-aba5-dc0ed3bb69fc">4,903</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i4649e39780384e179cb5b74b4192a407_I20151231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTktMS0xLTA_2281cd71-c17a-4f12-98d3-c59e84c860d6">429,491</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEzLTEtMS0w_c4058d9a-248f-4adb-a9c9-0df3360c7063">237,282</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Issuance of common stock under employee stock compensation plans, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEtMS0xLTA_351591cd-5553-4040-abca-71389d2ff42b">210,626</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTUtMS0xLTA_271677c6-d2c2-43c4-8c95-798edb669c82">5,416</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEzLTEtMS0w_fdc5efc4-146d-404d-9c9c-21f3d4e2dba4">5,416</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares issued in OMT acquisition</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodSharesAcquisitions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEtMS0xLTA_7e80e84f-ca24-4b43-b034-c49e024c74f9">790,163</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231" decimals="-3" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTMtMS0xLTA_2612a3fc-4f05-4378-8c86-efdf6881e719">1</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTUtMS0xLTA_181cc742-4ac7-4fc1-b8a0-6b400a529953">77,330</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEzLTEtMS0w_babda09b-4a4b-4a1f-83af-d3098953e055">77,331</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Reclassification of equity component of currently redeemable convertible notes</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTUtMS0xLTA_af80daa4-c0c4-4e1f-ab0b-08c4612a7483">10,065</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTEzLTEtMS0w_1d28e6c7-12da-4cf0-8562-795de5149b92">10,065</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTUtMS0xLTA_04612b0b-ceb9-43c3-be74-c0bd8f3a5a56">18,893</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTEzLTEtMS0w_6f188f6e-39ca-43c5-a68d-9e42658e3d81">18,893</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Repurchase of common stock</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEtMS0xLTA_85c20899-2314-4bb4-aabf-7b1571ba0563">40,500</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTUtMS0xLTA_da776cf1-d968-4cd0-b239-931edd8a3135">3,901</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEzLTEtMS0w_17c5d5f8-825d-4014-b7ed-e863b8a5e19c">3,901</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other comprehensive loss</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i1a2836d1fbd04b178ed87e38468a92c5_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTctMS0xLTA_0410ebd1-fabc-4c5b-9a91-b270b67029b3">2,160</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEzLTEtMS0w_7f1d7a99-dbfe-44e0-80a9-b39bd62b0010">2,160</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net loss</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i83e610145e1441a4a48edbf5a5efb62b_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTA_66f3a775-f722-4516-8433-5ad4348933e5">1,636</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEzLTEtMS0w_3a426e17-a028-4a5a-94f5-cd59ca828d60">1,636</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December 31, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i7da8d16c399b44818efd38241c41af9b_I20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:SharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEtMS0xLTA_66af52b2-3c58-4f7d-963d-c601e40826f7">20,909,301</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7da8d16c399b44818efd38241c41af9b_I20161231" decimals="-3" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTMtMS0xLTA_ff91d6f2-151a-4723-8df6-cabf33e2b509">21</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1119817d95d04c2b84b6f21adc149bc8_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTUtMS0xLTA_136aa39a-8f50-4f32-9aca-89a93c272637">769,653</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if8adb73be9d64177a10495f9d227b467_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTctMS0xLTA_173e47cd-02e3-4fca-9db6-242d94b073c3">2,743</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i619dc5c14c054866a55684440355f164_I20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTktMS0xLTA_f6a31ea6-12ff-498f-aba7-b103ce075aff">431,127</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEzLTEtMS0w_06079120-d599-493a-bc04-1a5a6f1303e9">341,290</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Issuance of common stock under employee stock compensation plans, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEtMS0xLTA_c6371a1e-4ee7-457c-aaea-89b34df6dde7">253,364</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTA_f235056e-d3ae-488c-9b34-d3c8faf977c8">5,558</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEzLTEtMS0w_02131e48-dddc-4a46-b373-f540b40da889">5,558</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Reclassification of equity component of currently redeemable convertible notes</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTUtMS0xLTA_e1af285b-7d0c-469a-aa80-d7b1d13e9241">10,704</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTEzLTEtMS0w_3379b0d6-eb65-4edf-953e-804c3de7ec3f">10,704</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTUtMS0xLTA_6d52e68b-9e90-4ff0-866a-5be50abe1ce9">24,916</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTEzLTEtMS0w_d950774d-cc97-40ef-ba40-ddd6657f7e69">24,916</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Repurchase of common stock</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTEtMS0xLTA_a10a7381-8a05-421c-be75-ff4426f1f86c">14,000</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTUtMS0xLTA_4043a915-c3b2-4aad-9ffe-ac3f64471fba">1,966</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTEzLTEtMS0w_91d602af-527d-42a2-b327-e2d8c806dc2d">1,966</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other comprehensive loss</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i188efce7ecde4338afd75e87443c6147_D20170101-20171231" decimals="-3" sign="-" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM1LTctMS0xLTA_49723613-b138-4809-924c-04f66e93c9c1">257</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM1LTEzLTEtMS0w_ba56df4d-97de-407a-ac06-f56ba8d50802">257</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cumulative-effect adjustment from adoption of ASU 2016-09</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i56fd83bc6dc042639ae1df971a9f4d20_I20170101" decimals="-3" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTUtMS0xLTA_e9b2b395-58bf-4e4b-ac06-85f8a3ceec47">456</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib96266c9cd9e42b68a5de54609fb51bd_I20170101" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTktMS0xLTA_72754b6e-0789-4202-9b59-1055462bc5c1">17,647</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i33d2f89847cf48949592096f2d579f2b_I20170101" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTEzLTEtMS0w_2bd288b3-e783-46ea-8b2b-9545e06dffa6">18,103</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1f9437583206454497ad1119bfadd777_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM3LTktMS0xLTA_a2ba8638-5228-4f4b-a7dc-7234c60572c4">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM3LTEzLTEtMS0w_a94d3ce9-e2c4-4bc3-b800-967c016f5b3a">12,556</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December 31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ic608cbca1fef42b885a41d66ca7b19bd_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:SharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTEtMS0xLTA_b246b383-e9a4-401a-8304-6bdda8754eb5">21,148,665</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic608cbca1fef42b885a41d66ca7b19bd_I20171231" decimals="-3" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTMtMS0xLTA_888766a2-93ec-4160-9056-011bec163b31">21</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8b39fe8e03bc43f49fbf934d621cb24c_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTUtMS0xLTA_ebdbfefd-ddcf-4b4a-a989-7ccdbff881c5">798,205</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2513fadb593f42d3b8500a28dadd898f_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTctMS0xLTA_59c114ba-2856-41c5-b623-afef13755bc5">2,486</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i16eca74f8d9c46a28663ad714fd5a4b5_I20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTktMS0xLTA_099e8a5b-258a-4a2b-b679-5109e3177ff7">400,924</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTEzLTEtMS0w_2f9ff596-dfbf-4fca-b823-fad9137c3984">399,788</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Issuance of common stock under employee stock compensation plans, net</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTEtMS0xLTEzOTQx_193d4af6-b6b8-44c0-be78-19c66714f243">399,116</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTUtMS0xLTE0MDQ2_eb43a71b-b6de-4599-8e3d-e68f5e18df50">16,417</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTEyLTEtMS0xNTE1NA_df92d205-2c05-454f-98d8-ec7aa5def65f">16,417</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Reclassification of equity component of currently redeemable convertible notes</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIwLTUtMS0xLTE0MDU0_9f979f2b-a244-47f5-b9b7-8932cb4119fc">18,859</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIwLTEyLTEtMS0xNTE1Ng_b574f7a9-ac0f-4260-86b9-99c2281457de">18,859</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Share-based compensation</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIxLTUtMS0xLTE0MDU3_62e5d722-7d2a-4ee9-af00-f2fb924b6193">20,846</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIxLTEyLTEtMS0xNTE1OA_ce09c6dc-5889-4623-9d68-fe926e3732af">20,846</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Repurchase of common stock</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEtMS0xLTEzOTQ1_3d1e2fdf-4822-4114-9def-08d6d98d8326">782,248</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTUtMS0xLTE0MDYw_c1ebc9c3-b702-48f3-a089-476842ce746c">127,481</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEyLTEtMS0xNTE1OQ_6151ec63-c396-4b6a-b3e3-d13b588a87d8">127,481</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Other comprehensive income</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTctMS0xLTE0MDc4_16b0fba6-ab50-41a7-b8d8-6a54e7956c1f">73</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span><ix:nonFraction unitRef="usd" contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231" xsi:nil="true" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTktMS0xLTE0ODc1_df00ec6b-10dc-47c5-b784-e3506db5adcd"></ix:nonFraction></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:OtherComprehensiveIncomeLossNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEyLTEtMS0xNTE2Mg_008450e2-c9b6-48f1-959e-8238268629ce">73</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Cumulative-effect adjustment from adoption of ASU 2016-01</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i8d92baeda9ac47a986e2a5bd6eacdbf2_I20180101" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTctMS0xLTE0MDk4_da406fa7-e103-4fed-bcab-8751cd8bcdd4">2,662</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i3574527256f745d8bcdc0cb4541c738e_I20180101" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTktMS0xLTE0MTA2_4ec19e6c-0ae8-4968-a15b-9795c66482e5">2,662</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i86047298eb4f4ea5ba70e04cad22157a_I20180101" decimals="-3" format="ixt:zerodash" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEyLTEtMS0yMDUwNQ_722d11b3-09f1-4921-aee4-7fa61991bb31">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Cumulative-effect adjustment from adoption of ASU 2014-09, net of tax</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic7fb939626f5447db0b459d9b7bc82d1_I20180101" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTktMS0xLTE0MTE2_6f57a0cd-a3f9-44f5-8443-001af3f070ab">25,581</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i933a7ea4fa9f4cc7bf26d93ee66f026b_I20180101" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTEyLTEtMS0xNTE2NA_61d92f0d-5e72-440e-a9cb-4491e1ead0b1">25,581</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Derivative associated with 2019 Notes and Bond Hedge</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTUtMS0xLTIxMzQ3_66503caf-82c4-47be-a415-c04c36c1257f">1,559</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTEyLTEtMS0yMTQwOA_2199e0f0-db9a-4d0d-a162-f0d3815c9417">1,559</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Loss on settlement of 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTUtMS0xLTE4MDM3_8b06a617-7990-4ccb-8ac5-dab23f5b90d8">3,187</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEyLTEtMS0yMTQwOQ_f41c4be3-133a-45d5-ac3a-9929c14cfdda">3,187</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Warrant repurchase in connection with 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTUtMS0xLTIxMzcz_59150ca9-a679-4c43-b846-e474b833734d">30,472</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEyLTEtMS0yMTQxMg_4cf68707-0007-4701-8b02-f4c4cf866c23">30,472</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Loss on repurchase of warrants in connection with 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTUtMS0xLTIxMzc2_9601d5b1-46fc-469d-bbb9-71e49dbf1f4e">1,792</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEyLTEtMS0yMTQxNA_d61b4343-936a-4e73-986b-45ad5e1d7573">1,792</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax effect on 2019 Notes transactions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTUtMS0xLTIxMzc5_f900c096-6673-4378-8ce3-65852816f6e4">1,680</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEyLTEtMS0yMTQxNQ_39d553c1-8588-4e06-8943-3c53b8f41bbf">1,680</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Derivative associated with 2023 Notes and Bond Hedge</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTIxMzgy_abbfe3ec-0960-4573-be69-f3362a7b26cd">1,807</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEyLTEtMS0yMTQxOA_a1ffddf3-35f4-4ab1-9a74-dd416207558f">1,807</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Warrant derivative  in connection with 2023 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTUtMS0xLTIxMzg1_a100b244-e8a7-4857-9bd1-02594575736f">97,805</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTEyLTEtMS0yMTQyMA_fdd5041e-0160-465f-9f51-60d39ad52c6a">97,805</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax effect for 2023 Notes transactions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTUtMS0xLTIxMzg4_0da46896-6ce5-4c5a-a007-eefcc4d2abc6">3,181</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTEyLTEtMS0yMTQyMg_545146ae-b598-4bd3-ad1b-85a069473a2e">3,181</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Foreign currency translation adjustment</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231" decimals="-3" sign="-" name="lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTctMS0xLTE0MTc5_35199ab6-969a-4e77-897e-7866c411ff41">921</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEyLTEtMS0xNTE3MA_14dd086e-5949-4a67-ada1-442026ef859d">921</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other tax adjustments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231" decimals="-3" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTUtMS0xLTE0NjUz_867106fc-f6f4-45ef-909c-b5e6f421a97c">183</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231" decimals="-3" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTE0NjU1_7525e131-188f-46cc-9cfd-a6c55dde0fac">163</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEyLTEtMS0xNTE3Mg_a0f37a42-88a1-423d-a5c8-205055fcd1b1">346</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTE0MTIx_f0f4b2d2-5440-4d3b-be0d-7462963a792a">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEyLTEtMS0xNTE3NA_e91ab0ad-9ec6-49c9-9f1f-d94adf87c336">143,321</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.5pt;font-weight:400;line-height:100%;">Balance at December 31, 2018</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:SharesOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEtMS0xLTE1MTg2_103ccf4f-f7ec-475d-9475-ede8c2da62e2">20,765,533</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231" decimals="-3" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTMtMS0xLTE1MTg0_c7b7d59b-3a08-4c36-bb83-d61034ef96a1">21</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia9f65f9bd2374512bb8783927196d39a_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTE1MTgy_efc9b5be-2422-4bfc-8518-30e81875cd7a">791,114</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ibcb5b487ee794160bf522b883cfa27c7_I20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTctMS0xLTE1MTgw_55b6d962-8bb5-4851-828a-18015a1f4e37">1,024</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id4a587395c674ab4bf495afb6bd1140b_I20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTktMS0xLTE1MTc4_afc141e7-e2c3-449d-8cef-69d6b7774638">229,197</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:7.5pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEyLTEtMS0xNTE3Ng_36c7061a-5682-4f0c-be9e-2606d8d80740">560,914</ix:nonFraction>&#160;</span></td></tr></table></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-style:italic;line-height:120%;">See accompanying notes to these consolidated financial statements.</span></div><div id="i_0_334"></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">52</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</span></div><div style="text-align:center;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">CONSOLIDATED STATEMENTS OF CASH FLOWS</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(in thousands)</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:58.588235%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year&#160;Ended&#160;December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Revised)*</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Revised)*</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Operating activities</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)  </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProfitLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtMS0xLTEtMA_853d1cbb-19c2-46cd-87e5-b6d97105b037">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProfitLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtMy0xLTEtMA_a0f790ae-5ae1-49a5-9ee6-c858b16bffd1">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:ProfitLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtNS0xLTEtMA_be26da41-ba50-4304-bb3e-b3102aa21335">1,636</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less: income from discontinued operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtMS0xLTEtMA_423bc23c-8643-4940-bd18-76016af276c8">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtMy0xLTEtMA_03961f27-74b7-4bd5-91c5-1de26ab1782a">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtNS0xLTEtMA_ecbcba9a-0758-416f-b997-dc71e5523627">731</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income (loss) from continuing operations</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtMS0xLTEtMA_9d04916a-7c3a-4f5b-8ab4-468b6274c584">143,321</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtMy0xLTEtMA_c126b8ed-4283-4eff-8e59-dfa225c27a37">12,556</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtNS0xLTEtMA_e0a877be-2d7b-4566-b67b-474372e2991c">2,367</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Adjustments to reconcile net income to net cash provided by operating activities:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in estimated fair value of contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtMS0xLTEtMA_1a6370d9-0032-47e8-96ee-e6d9d98a1e93">3,448</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtMy0xLTEtMA_344a76ea-bcbd-4df2-8b75-b425cb05a741">2,580</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtNS0xLTEtMA_8e27f798-3f1c-4e0c-9a4d-a800a0b497a7">3,334</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Realized gain on sale of short-term investment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RealizedInvestmentGainsLosses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktMS0xLTEtMA_ee4f41f1-6e48-497a-a675-b63fff0f4e0f">2,611</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:RealizedInvestmentGainsLosses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktMy0xLTEtMA_7fc51e51-b827-4289-9979-dc207ae49205">831</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RealizedInvestmentGainsLosses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktNS0xLTEtMA_1dacd750-27e6-49ed-aa70-a5b7d8594e97">2,352</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Depreciation and amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DepreciationDepletionAndAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTEtMS0xLTA_14a14322-4e81-437a-bbc2-76fe6375a83e">14,718</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DepreciationDepletionAndAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTMtMS0xLTA_029e3a3f-bd75-40af-8840-f395438eac71">11,714</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DepreciationDepletionAndAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTUtMS0xLTA_f6ff2213-6749-448a-bd64-3a28831b7ec3">11,290</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Gain) loss on equity investment in Viking </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTEtMS0xLTA_145c7d91-dadd-4513-8df6-4ec320db6d50">42,346</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTMtMS0xLTA_4fc61c55-2dbb-40bd-bea4-73c8391a35a6">2,048</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeLossFromEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTUtMS0xLTA_6ddb0b0c-f2d1-414a-95fa-ad2904619be5">23,132</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in fair value of the convertible debt receivable from Viking and warrants</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTEtMS0xLTA_0e0b32a4-355c-498c-8333-5e6bef5564f2">5,411</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTMtMS0xLTA_a16c4554-b642-40a8-94a4-09e224ee27e2">4,032</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTUtMS0xLTA_73b8ea51-51fa-454c-b871-2b79ad0c6673">462</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Amortization of premium (discount) on investments, net</span></div><div style="text-indent:12pt;padding-left:12pt;"><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTEtMS0xLTA_96b47567-0776-4669-b22f-c2d6c96f22b4">5,452</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTMtMS0xLTA_7a181494-3b62-41a7-a708-7b0792e14986">81</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTUtMS0xLTA_dc1aee6c-1224-4827-81fc-8e64b5b65ecb">348</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amortization of debt discount and issuance fees</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfFinancingCostsAndDiscounts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTEtMS0xLTA_56cc12b6-984e-4a9a-b731-b5c2a6d2714e">43,954</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfFinancingCostsAndDiscounts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTMtMS0xLTA_6896947d-d432-4e18-933d-b96ba68c35e3">11,619</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfFinancingCostsAndDiscounts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTUtMS0xLTA_dd0bb8d7-1c80-40cc-8e95-7039708e9eac">10,925</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTEtMS0xLTA_5d8d2892-6dc1-41d6-ba4c-8c4c83091513">20,846</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTMtMS0xLTA_48b94be0-045f-4872-95ab-7cee48ee5fe6">24,915</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTUtMS0xLTA_71c0693b-649f-4565-ac24-651ca59fe756">18,893</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred income taxes, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDeferredIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTEtMS0xLTA_4aeaf9b8-5a84-47ac-b16e-e2eb23675191">29,739</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDeferredIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTMtMS0xLTA_828d9f3f-32a8-4ab2-a5a7-8204fee3f159">44,518</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDeferredIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTUtMS0xLTA_e535e878-a844-4335-afed-46e3cb408357">10,697</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties recorded in retained earnings upon adoption of ASC 606 </span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTEtMS0xLTk2Mjg_17331565-46b3-4fba-98f5-3e75b69cb4dd">32,707</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTMtMS0xLTk2MzE_68b40425-8f1e-48ed-a718-81502d71aeda">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTUtMS0xLTk2MzQ_e2caf34f-4118-4cc9-8b51-981f6698a66c">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in derivative asset and liability fair value</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:ChangeInDerivativeAssetAndLiabilityFairValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTEtMS0xLTE0OTg4_4e550a09-5998-406b-b8f7-3fc3bb2c403f">2,931</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:ChangeInDerivativeAssetAndLiabilityFairValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTMtMS0xLTE0OTkx_58a8e602-11a9-431f-8e32-43f289c7508a">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="lgnd:ChangeInDerivativeAssetAndLiabilityFairValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTUtMS0xLTE1MDE3_c71cfed1-f97d-4d44-9e91-48eea9bb897d">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Changes in operating assets and liabilities, net of acquisitions:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts receivable, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTEtMS0xLTA_3cd86452-10f5-44c6-8370-0d99a23fbc39">29,544</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTMtMS0xLTA_be0e8401-f3a8-4386-a1fc-f070c4b8891a">8,358</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTUtMS0xLTA_331f1226-f516-429b-afad-e6f998d24cb6">8,525</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Inventory</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInInventories" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTEtMS0xLTA_67ee2e0c-ec85-4b41-92b4-80e014ccee30">2,559</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:IncreaseDecreaseInInventories" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTMtMS0xLTA_5ed788ca-427e-4e98-958f-7411cf6d1d84">843</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:IncreaseDecreaseInInventories" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTUtMS0xLTA_7b7cc18f-0bee-4b2b-acce-ecab20836a49">244</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTEtMS0xLTA_2d530ae8-59d9-4d89-a97d-38097232d86d">868</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTMtMS0xLTA_7eac5f12-1909-40f0-bcdf-852f76a845d1">402</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTUtMS0xLTA_4e80cc5f-868b-43a7-8d4f-d63f7f28ca1e">526</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other long term assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInOtherNoncurrentAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTEtMS0xLTA_a7355ebc-98c9-4698-b9e4-e4d4f7a9ebfd">728</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncreaseDecreaseInOtherNoncurrentAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTMtMS0xLTA_e3eccfd6-2bdb-4e23-8bf0-fb532d562af8">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInOtherNoncurrentAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTUtMS0xLTA_c29d5f63-fb95-49cb-aec7-b64482959fc9">183</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts payable and accrued liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTEtMS0xLTA_2ac54c47-640a-4710-94f8-64434c6c5928">4,542</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTMtMS0xLTA_5aefccf6-71f0-461f-98de-480c756d04c0">1,713</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTUtMS0xLTA_c14e178f-75f0-4515-bfd1-c6726dc8ed24">2,369</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseInContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTEtMS0xLTk2MTk_d20cd68a-d3e1-494b-b178-a999473af305">3,842</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseInContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTMtMS0xLTk2MjI_38eb4298-df4e-4250-9a6f-f8118e4d3bc2">4,998</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseInContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTUtMS0xLTk2MjU_917a24f9-cc25-45f7-8a22-35784c8e07e6">2,268</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:24pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInContractWithCustomerLiability" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTEtMS0xLTA_2fb4b690-1fd2-4069-81b2-9dced0371e9e">1,158</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInContractWithCustomerLiability" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTMtMS0xLTA_0195a133-75b6-4043-b5aa-32027b096111">926</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:IncreaseDecreaseInContractWithCustomerLiability" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTUtMS0xLTA_191bc0e5-9303-46cb-b19e-b6717ddeea1c">8</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:36pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net cash provided by operating activities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInOperatingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTEtMS0xLTA_9643886d-575d-4fb9-8989-49a91ff09c95">194,059</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInOperatingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTMtMS0xLTA_823dfafe-3593-464f-8b4c-6edabd774193">88,570</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInOperatingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTUtMS0xLTA_9afd5d97-9177-4bd1-a336-9413f01d142d">60,733</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investing activities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Purchase of commercial license rights</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PurchaseforCommercialLicenseRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTEtMS0xLTA_358442aa-40ee-4cf7-af03-68978e82227e">10,000</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PurchaseforCommercialLicenseRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTMtMS0xLTA_4c5beb7c-891a-4943-be27-9f6ababa802e">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PurchaseforCommercialLicenseRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTUtMS0xLTA_8541604b-2780-46f5-bd62-bbad18974266">17,695</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Purchase of Viking common stock and warrant</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibf1a2a4d3d614da2a9e3262a761010bc_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTEtMS0xLTA_a510a545-bc12-4dd0-b62d-f800117e5a52">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i346f6d3d9c4c4913bcb746295c506010_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTMtMS0xLTA_07019c96-8dfb-443d-979d-cdcff9334e40">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i4604c286cb3b4c23b3e7c54016351f4f_D20160101-20161231" decimals="-3" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTUtMS0xLTA_1d28e836-b2ec-410f-b052-ce73c3f31aaa">700</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Purchase of common stock in equity method investment</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i38e7892ad1fc44c687187391e73e15ad_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTEtMS0xLTA_3c1bc5f9-97ba-417a-807e-d94b80144d80">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i401746069dc0428bae920f833bd24769_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTMtMS0xLTA_92a588e2-d2ad-403e-8d76-0947ca825241">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i152983bb0da8462dbdf2be5c4ba3bc18_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTUtMS0xLTA_e5c6611c-e211-4966-b1a1-2450010465ce">1,000</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Cash paid for acquisition, net of cash acquired</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTEtMS0xLTA_1ff13a51-2ebb-4381-a1b7-ac67d26a7e92">5,856</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTMtMS0xLTA_5aaae271-5394-4723-a9d1-b66b205165a5">26,653</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTUtMS0xLTA_6d5da46f-2a86-465c-abfa-59fa2affd5e9">92,502</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to CVR holders and other contingency payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTEtMS0xLTA_e2e2747e-3e8c-4e49-a184-d227f441103d">1,000</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTMtMS0xLTA_4024e2df-f891-485e-bc5e-86c547823bdc">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTUtMS0xLTA_5bc1b072-4855-4bf7-87d1-ee2aacd41784">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Purchases of property and equipment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:PaymentsToAcquirePropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTEtMS0xLTA_03670169-0dc7-4146-b92f-5b5a9acbb059">887</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquirePropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTMtMS0xLTA_dd016c35-ba0e-4c4c-97ee-6322590f5d39">2,156</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquirePropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTUtMS0xLTA_714728f6-9551-46e6-986f-7e5e830d7687">1,850</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Purchases of short-term investments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTEtMS0xLTA_5780df80-48be-4dbf-875f-f77ce764961b">1,434,255</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTMtMS0xLTA_7d7212ed-9b40-48e4-86ea-e37f73bf5613">254,258</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTUtMS0xLTA_52f5947c-9309-4083-8a67-b96f265f937a">164,438</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Proceeds from sale of short-term investments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromSaleOfShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTEtMS0xLTA_217f6d53-6af8-4d20-948d-56ed2afeabe0">131,942</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromSaleOfShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTMtMS0xLTA_697d2910-af28-4234-97c9-8668e9cb847a">86,985</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromSaleOfShortTermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTUtMS0xLTA_6dcd3e08-0f01-4e76-82c6-5994d548bf0c">24,596</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Proceeds from maturity of short-term investments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTEtMS0xLTA_6074d12d-1fce-41fe-8cb1-bd7d96b7efb7">892,873</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTMtMS0xLTA_792341eb-21e2-4587-9bfe-e5be8229899b">109,649</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTUtMS0xLTA_2297d17d-67ea-400c-b788-497e6b692403">118,874</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Proceeds from commercial license rights</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromLicenseFeesReceived" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTEtMS0xLTA_6d09081b-812d-4501-baec-3b73a06e8095">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromLicenseFeesReceived" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTMtMS0xLTA_7f8df465-bdbe-49ca-93ac-a432f80ef60c">7,054</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromLicenseFeesReceived" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTUtMS0xLTA_4ddb7ba1-e581-4879-9927-4ed1a91866b9">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Proceeds received from repayment of Viking note receivable</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromCollectionOfNotesReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTEtMS0xLTA_c34a59e2-0096-4886-a9c3-5843c3d38bbb">3,914</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:ProceedsFromCollectionOfNotesReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTMtMS0xLTA_66731934-53d6-4bc6-a91a-73ee94e668e4">200</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:ProceedsFromCollectionOfNotesReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTUtMS0xLTA_d8d28787-5e2b-431a-91b0-b1938f57e5ac">300</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:36pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net cash used in investing activities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInInvestingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTEtMS0xLTA_749c1d26-7f02-4679-a5a1-67b3baef44e7">423,269</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInInvestingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTMtMS0xLTA_12a937af-8d79-463d-a4cb-c55d87c204a6">79,179</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInInvestingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTUtMS0xLTA_d03b9555-e8a8-4fd8-836e-6b75bfed734f">134,415</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Financing activities</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Repayment of debt</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RepaymentsOfLongTermDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTEtMS0xLTE0ODg1_c3ad89b2-33fd-4f3f-9807-8a960cace329">217,674</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:RepaymentsOfLongTermDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTMtMS0xLTE0ODg3_8decc827-5d88-4aad-b8c7-2b8770b2c03f">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:RepaymentsOfLongTermDebt" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTUtMS0xLTE0ODg5_d03496e6-8e44-46d9-866e-d0d052f865c2">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Gross proceeds from issuance of 2023 Convertible Senior Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromNotesPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTEtMS0xLTE0OTA1_81f96b23-931f-4c00-aa3c-973ece0036f8">750,000</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromNotesPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTMtMS0xLTE0OTA3_254a019d-364f-4c6a-ad80-2f379ddd875d">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromNotesPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTUtMS0xLTE0OTA5_cf581d11-34ba-43d5-a4a8-e2eeafb47b85">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payment of debt issuance costs</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsOfDebtIssuanceCosts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTEtMS0xLTE0OTE1_f9254e84-61dd-4aff-9fff-afef3668f3a4">16,900</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsOfDebtIssuanceCosts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTMtMS0xLTE0OTE3_d9f028ad-1ea6-4800-a324-55edfcbd8cf3">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsOfDebtIssuanceCosts" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTUtMS0xLTE0OTE5_0b401994-8f31-45c6-ab3b-0b3282565beb">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Proceeds from issuance of warrants</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromIssuanceOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTEtMS0xLTE0OTI0_d5829141-f762-4206-80fb-da3bda91d16b">90,000</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromIssuanceOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTMtMS0xLTE0OTI2_ad90100b-b795-47a5-8d0d-b990f20a2109">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromIssuanceOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTUtMS0xLTE0OTI4_caadccc4-f493-4805-8c4f-b9c0fa19d837">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Purchase of convertible bond hedge</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PurchaseOfConvertibleBondHedge" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTEtMS0xLTE0OTMy_db7c6c18-6585-464a-8435-0c37bfcbf372">140,250</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PurchaseOfConvertibleBondHedge" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTMtMS0xLTE0OTM0_259e4f51-ad2b-4e49-914c-4fbd034bd810">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="lgnd:PurchaseOfConvertibleBondHedge" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTUtMS0xLTE0OTM2_e214a124-8e05-4b41-99c6-1cf26abd10ca">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Proceeds from bond hedge settlement</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTE0OTQ4_417feb08-a5d9-4f83-89d3-29ccd19e6ac4">439,559</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTE0OTUw_f9f0cebd-0d08-421b-9460-abd601047a7e">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:ProceedsFromHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTE0OTUy_b4291aac-020e-489e-8cde-9a309debc979">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to convert holders for bond conversion</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsForHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTEtMS0xLTE0OTU3_1c038e77-ade8-4a70-8e59-e0eb95c9944b">439,581</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsForHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTMtMS0xLTE0OTU5_396a28fc-8417-4537-bbf5-16bd981fe10d">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsForHedgeFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTUtMS0xLTE0OTYx_aed12e35-ed20-4c40-8e02-114be66cf647">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net proceeds from stock option exercises and ESPP</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromStockOptionsExercised" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTEtMS0xLTA_53749a6c-1bf5-48e7-b8dc-19cd87791269">20,183</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromStockOptionsExercised" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTMtMS0xLTA_81d04dbb-a960-45c3-bad6-494e5becd324">4,517</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromStockOptionsExercised" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTUtMS0xLTA_0c5f181f-fe72-48fc-8d1f-b3a95404bf6e">6,415</ix:nonFraction>&#160;</span></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">53</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:58.588235%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.647059%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Taxes paid related to net share settlement of equity awards</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTEtMS0xLTA_979227bb-d35c-4545-b820-26d8139f0e24">3,765</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTMtMS0xLTA_fc44ef7f-3218-4b00-9e5b-145b4baec66a">10,074</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTUtMS0xLTA_ed47af36-5805-448a-9d3f-1d2af6d6e4a0">999</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share repurchases</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsForRepurchaseOfCommonStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTEtMS0xLTA_740bb4c5-42d4-45a6-b6b5-41436eb837a2">122,868</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsForRepurchaseOfCommonStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTMtMS0xLTA_053a4bdd-7320-4ab9-a82c-6d6b1dc53307">1,966</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsForRepurchaseOfCommonStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTUtMS0xLTA_afcc24d1-be07-414a-8201-9b1009f4581d">3,901</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Repurchase of warrants</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsForRepurchaseOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTk2NjU_1dee43ed-1f2b-4fe0-b8cd-f083549f15d8">30,094</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsForRepurchaseOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTk2NzQ_b212f0df-9253-4c98-84e6-bf555edd3eb1">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:PaymentsForRepurchaseOfWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTk2Nzc_9ae0e5fc-e142-4281-96dd-c8d6f12cf9d4">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to CVR Holders</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="lgnd:PaymentsToContingentValueRightHoldersFinancingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTEtMS0xLTE3Mjc3_fb30abd5-841e-45ce-bae3-2d8840cba34c">25</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PaymentsToContingentValueRightHoldersFinancingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTMtMS0xLTE3Mjgw_5137e93c-bfd3-49ba-8ba1-f8e9e0eeb039">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#bfe4ff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#bfe4ff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHoldersFinancingActivity" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTUtMS0xLTE3Mjgz_74533b1a-5727-4f7e-9de9-417f7c9c0eb2">6,509</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:36pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net cash provided by (used in) financing activities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTEtMS0xLTA_6cd8a697-a176-4365-a68e-e042b482b12c">328,585</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTMtMS0xLTA_e0349bc7-d46f-4efc-91ab-4e902dc38124">7,523</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInFinancingActivities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTUtMS0xLTA_6c361a68-beaa-478d-b4cb-10934a29d397">4,994</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Effect of exchange rate changes on cash</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTEtMS0xLTk2ODQ_8a2d6479-e5f7-45dc-a00c-ea01fdcafb8d">215</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTMtMS0xLTk2ODc_9b7be5ab-7cd7-4147-8d0b-0ffe3aca0d81">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTUtMS0xLTk2OTY_9608a1dc-ae7c-4c11-aa1a-dd2cba48879c">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net increase (decrease) in cash and cash equivalents</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTEtMS0xLTA_4c58645e-134b-4036-93a2-4bd38c7324ed">99,375</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTMtMS0xLTA_b2249821-8691-4c55-a74a-1fd2fd9a18a1">1,868</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTUtMS0xLTA_14a95eae-3acd-4b4d-9a2d-fe4eb992649e">78,676</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash, cash equivalents and restricted cash at beginning of year</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTEtMS0xLTA_4ff23a1e-f8ce-4415-9d4e-fd69f72758d3">20,620</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTMtMS0xLTA_d3af713c-360a-485b-af0e-dbf2a8609e86">18,752</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTUtMS0xLTA_70840fa6-0e6d-4191-a15d-f4013ec78898">97,428</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash, cash equivalents and restricted cash at end of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTA_370b1ffb-a863-4982-86df-49e65a0fe258">119,780</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTA_762130f8-a0aa-4318-82a2-a00b3eff09eb">20,620</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTA_05871cb5-0443-4cab-b4c7-b6e39041c4cb">18,752</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supplemental disclosure of cash flow information</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash paid during the year:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest paid</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestPaidNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTEtMS0xLTA_8fd32409-eb35-41f5-b55c-6106900228ee">1,513</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestPaidNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTMtMS0xLTA_54ef32dc-f69b-425e-be54-805f4ffb6b29">1,838</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:InterestPaidNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTUtMS0xLTA_7475484e-4490-43a2-9f5a-5f29f1c05f8f">1,838</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Taxes paid</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:IncomeTaxesPaid" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTEtMS0xLTA_15e263c8-24cf-4f82-9d1c-a40366a74040">341</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:IncomeTaxesPaid" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTMtMS0xLTA_71315ea7-fcad-47e1-9cca-f2eb3d886c20">157</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:IncomeTaxesPaid" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTUtMS0xLTA_b8e77169-90d9-4fa7-b9f6-343aed77e62f">38</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supplemental schedule of non-cash investing and financing activities</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">Stock issued for acquisition, net of issuance cost</span></div><div><span><br/></span></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTEtMS0xLTA_2d03fe5e-4f0d-4883-a917-9228082ffcc2">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTMtMS0xLTA_cb80981b-61cc-4452-a8cc-a433b7038645">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodValueAcquisitions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTUtMS0xLTA_bff20ba1-e7cf-47c9-bca9-c351839ee3f9">77,331</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Stock and warrant received for repayment of Viking notes receivable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="lgnd:EquityReceivedinRepaymentofNoteReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTEtMS0xLTA_dcf78d33-a28a-4cc6-8711-011506a3e2b1">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:EquityReceivedinRepaymentofNoteReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTMtMS0xLTA_39725617-60ce-42c0-a4ed-6fa051f491b1">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:EquityReceivedinRepaymentofNoteReceivable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTUtMS0xLTA_62fdb617-a795-4457-8574-402fbbee63bb">1,200</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accrued inventory purchases</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AccruedInventoryPurchases" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTEtMS0xLTA_90592db0-eb72-480e-9244-3441367dc56f">2,059</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AccruedInventoryPurchases" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTMtMS0xLTA_c6187a3a-b577-4c64-937c-29bce27c15c8">1,007</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="lgnd:AccruedInventoryPurchases" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTUtMS0xLTA_7b11e7d8-4ddf-46f8-b507-2f81bc55650f">646</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unrealized gain on AFS investments</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:UnrealizedGainLossOnInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTEtMS0xLTA_17412192-1db5-4da1-8434-c646aee4beb0">48</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:UnrealizedGainLossOnInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTMtMS0xLTA_8acdedc9-37be-457b-b0e9-eb8c916bfe8a">144</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:UnrealizedGainLossOnInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTUtMS0xLTA_95a99187-bacc-45c6-afec-e6fa2d24090e">1,109</ix:nonFraction>)</span></td></tr></table></div><div style="margin-top:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">*See Note (1) for detail on the revision.</span></div><div style="text-align:center;margin-top:3pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">See accompanying notes to these consolidated financial statements.</span></div><div id="i_0_346"></div><div style="text-align:center;"><span><br/></span></div><div id="i_0_359"></div><div style="margin-top:14pt;"><span><br/></span></div><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">54</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Unless the context requires otherwise, references in this report to &#8220;Ligand,&#8221; &#8220;we,&#8221; &#8220;us,&#8221; the &#8220;Company,&#8221; and &#8220;our&#8221; refer to Ligand Pharmaceuticals Incorporated and its consolidated subsidiaries.</span></div><div><span><br/></span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">1. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU0_2ea7b012-b03d-4848-9c7d-d5e294a1e9ef" continuedAt="i0742c34a95ad441dacc692575bafc387" escape="true">Basis of Presentation and Summary of Significant Accounting Policies</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i0742c34a95ad441dacc692575bafc387" continuedAt="ia9a0d3655bf34c349230c9f16d84348a"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Business</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ligand is a biopharmaceutical company with a business model based on developing or acquiring assets which generate royalty, milestone or other passive revenue for the Company using a lean corporate cost structure. We operate in one business segment: development and licensing of biopharmaceutical assets.</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ConsolidationPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU1_0990d2a4-00a6-48cf-bc9b-7e05d29a49ef" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Principles of Consolidation</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The accompanying consolidated financial statements include Ligand and its wholly-owned subsidiaries.  All significant intercompany accounts and transactions have been eliminated in consolidation.</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:BasisOfAccountingPolicyPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ5NTA_b465c37e-8df5-41ac-a60c-4ef4918b5b57" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Basis of Presentation</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our consolidated financial statements have been prepared in accordance with U.S. GAAP and include the accounts of our parent company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation.</span></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:PriorPeriodReclassificationAdjustmentDescription" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU2_f9ae1702-2f51-4e85-b063-227b6457633c" continuedAt="i67b7c30d831b40dab8e2ce15424465ca" escape="true">Reclassifications</ix:nonNumeric></span></div><div><span><br/></span></div><div><ix:continuation id="i67b7c30d831b40dab8e2ce15424465ca" continuedAt="ib0c1e2d5b55f442099e2dd83808aff94"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Certain reclassifications have been made to the previously issued statement of operations to conform with the current period presentation. See detail in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Accounting Standards Recently Adopted</span></ix:continuation><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="ib0c1e2d5b55f442099e2dd83808aff94"> subsection below for further information.</ix:continuation> </span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:UseOfEstimates" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU3_d4867b29-20de-4c98-a15b-9180d9e6f99b" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Use of Estimates</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preparation of consolidated financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes.  Actual results may differ from those estimates.</span></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ConcentrationRiskCreditRisk" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU4_2812d37c-5645-45e6-9b35-af3109c8d3fc" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Concentrations of Business Risk</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Financial instruments that potentially subject to significant concentrations of credit risk consist primarily of cash equivalents and investments. We invest&#160;excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates.</span></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A relatively small number of partners account for a significant percentage of our revenue. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDY_0da18747-1e49-4c19-b89b-84393ac28091" continuedAt="if0fd74df05c646dca8d87fd7f19a5ab1" escape="true">Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:</ix:nonNumeric></span></div><div style="margin-bottom:6pt;"><ix:continuation id="if0fd74df05c646dca8d87fd7f19a5ab1"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"></td><td style="width:52.344624%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:12.727541%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.727541%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.727541%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner A</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItMS0xLTEtMA_be4f7d08-1296-4d36-a048-7ccaa736778f">40</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i3029e46160e643808e723653c88b6bac_D20170101-20171231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItMy0xLTEtMA_a01ebe98-1c86-4feb-a4dc-3fe964fdd82b">46</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i223dab5f73e347b9b79caa31f48b5d33_D20160101-20161231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItNS0xLTEtMA_a9e34c57-47c1-443d-a3ed-f182ebbfe39b">41</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner B</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="iad54ce0fea834c76ad026f321579313c_D20180101-20181231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtMS0xLTEtMA_7d504e23-1595-4be7-9a9f-d69f3b05ae76">13</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i43cdf2b8a77549fda2334e555da01d30_D20170101-20171231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtMy0xLTEtMA_c0b5d7cd-f4a3-45c4-b553-d5fad33d01ef">19</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i966b40b605c54c23a7a845e4be0cfade_D20160101-20161231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtNS0xLTEtMA_28ec09ec-06f0-4901-84b6-74468cfafdcf">14</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner C</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i1c82d6eeab5342c98f34c3b8321892fc_D20180101-20181231" decimals="2" name="us-gaap:ConcentrationRiskPercentage1" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtMS0xLTEtMA_2f37ec08-180e-43fd-bbb4-5a9299bb6f82">20</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; <ix:nonFraction unitRef="number" contextRef="i2153cdb62e2e4f53a2c6274726b9b87a_D20170101-20171231" decimals="2" format="ixt:numdotdecimal" name="us-gaap:ConcentrationRiskPercentage1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtMy0xLTEtMA_db740372-c375-4992-86e8-ba471cc0368e">10</ix:nonFraction>%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; <ix:nonFraction unitRef="number" contextRef="i151ec7ab8a8b4a41b242da4ab90bcbae_D20160101-20161231" decimals="2" format="ixt:numdotdecimal" name="us-gaap:ConcentrationRiskPercentage1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtNS0xLTEtMA_5edec102-ffd5-4b9e-9e99-b4e564d86760">10</ix:nonFraction>%&#160;</span></td></tr></table></ix:continuation></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We obtain Captisol from two sites at a single supplier, Hovione.&#160;If this supplier were not able to supply the requested amounts of Captisol from each site, and if our safety stocks of material were depleted, we would be unable to continue to derive revenues from the sale of Captisol until we obtained material from an alternative source, which could take a considerable length of time.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYw_23dfb433-205b-4aca-9589-8353614edfc3" continuedAt="i36e5ee42df5b44dfbc08121fe3c06465" escape="true">Cash Equivalents &amp; Short Term Investments</ix:nonNumeric></span></div></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">55</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ia9a0d3655bf34c349230c9f16d84348a" continuedAt="i7b11e336a0724f4887855ffd5559e52c"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i36e5ee42df5b44dfbc08121fe3c06465">Cash equivalents consist of all investments with maturities of&#160;three months or less from the date of acquisition. Short-term investments primarily consist of investments in debt securities that have effective maturities greater than&#160;three&#160;months and less than twelve months from the date of acquisition. We classify our short-term investments as "available-for-sale". Such investments are carried at fair value, with unrealized gains and losses included in the statement of comprehensive income (loss).&#160;We determine the cost of investments based on the specific identification method.</ix:continuation>&#160;</span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:AllowanceForDoubtfulAccountsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYx_316ac9ba-e544-444c-bec7-ed16095b2e57" escape="true"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounts Receivable</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Trade accounts receivable are recorded at the net invoice value and are not interest bearing. We consider receivables past due based on the contractual payment terms which range from 30 to 90 days. We&#160;reserve specific receivables if collectability is no longer reasonably assured. We re-evaluate such reserves on a regular basis and adjust the reserves as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.</span></div></ix:nonNumeric><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:InventoryPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYy_3aa019b6-6286-4921-b109-cb608f900292" continuedAt="ie40b8dfab8a14e77af398b1609efe4b6" escape="true">Inventory</ix:nonNumeric></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="ie40b8dfab8a14e77af398b1609efe4b6">Inventory, which consists of finished goods, is stated at the lower of cost or market value. We&#160;determine cost using the first-in, first-out method. We analyze our inventory levels periodically and write down inventory to net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.</ix:continuation> There were <ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt-sec:numwordsen" name="us-gaap:InventoryWriteDown" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQzMjM_12d3e41e-64dd-4dfd-8f18-88a104bbaafb">no</ix:nonFraction> write downs related to obsolete inventory recorded for the years ended December&#160;31, 2018,&#160;2017 and&#160;2016.  </span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:PropertyPlantAndEquipmentPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY0_2b82e4a3-5b97-4e49-84f3-f9c0cb526671" escape="true"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and Equipment</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, which generally range from three to ten years, using the straight-line method. Amortization of leasehold improvements is recorded over the shorter of the lease term or estimated useful life of the related asset. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:BusinessCombinationsPolicy" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY1_0431d546-913d-4ff9-9847-8ff5f48aa930" continuedAt="id4efbd121cd44f53ab0520aca0f03574" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Business Combinations</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition method of accounting for business combinations requires us to use significant estimates and assumptions, including fair value estimates, as of the business combination date and to refine those estimates as necessary during the measurement period (defined as the period, not to exceed one year, in which we may adjust the provisional amounts recognized for a business combination).</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting, we recognize separately from goodwill the identifiable assets acquired, the liabilities assumed, including contingent consideration and all contractual contingencies, generally at the acquisition date fair value. Contingent purchase consideration to be settled in cash are remeasured to estimated fair value at each reporting period with the change in fair value recorded in other income (expense), net. Costs that we incur to complete the business combination such as investment banking, legal and other professional fees are not considered part of consideration and we charge them to general and administrative expense as they are incurred. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We measure goodwill as of the acquisition date as the excess of consideration transferred, which we also measure at fair value, over the net of the acquisition date amounts of the identifiable assets acquired and liabilities assumed. In addition, IPR&amp;D is capitalized and assessed for impairment annually.  IPR&amp;D is amortized upon product commercialization or upon out-licensing the underlying intellectual property where we have no active involvement in the licensee's development activities. IPR&amp;D is amortized over the estimated life of the commercial product or licensing arrangement.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Should the initial accounting for a business combination be incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date and we record those adjustments to our financial statements in the period of change, if any.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting for business combinations, if we identify changes to acquired deferred tax asset valuation allowances or liabilities related to uncertain tax positions during the measurement period and they relate to new information obtained about facts and circumstances that existed as of the acquisition date, those changes are considered a</span></div></ix:nonNumeric></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">56</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i7b11e336a0724f4887855ffd5559e52c" continuedAt="i6f7edecce6e94e2b974d3d10fac5964a"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="id4efbd121cd44f53ab0520aca0f03574"> measurement period adjustment and we record the offset to goodwill. We record all other changes to deferred tax asset valuation allowances and liabilities related to uncertain tax positions in current period income tax expense.</ix:continuation> </span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Contingent Liabilities</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of Crystal in October 2017, we may be required to pay up to an additional $<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgwOTM_25b9e0ec-6908-4d19-9d60-062c09c03e42">10.5</ix:nonFraction> million in purchase consideration upon achievement of certain commercial and development milestones to the Crystal shareholders. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of CyDex in January 2011, we recorded a contingent liability for amounts potentially due to holders of the CyDex CVRs and former license holders. The liability is periodically assessed based on events and circumstances related to the underlying milestones, royalties and material sales.  In connection with the acquisition of Metabasis in January 2010, we issued Metabasis stockholders <ix:nonFraction unitRef="right" contextRef="i269cf529b8f542d6b6e89cfb73d21395_I20100131" decimals="INF" format="ixt-sec:numwordsen" name="lgnd:NumberOfContingentValueRightsIssued" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzg3NTY_290516fb-145f-4d62-bb99-e3b640512e52">four</ix:nonFraction> tradable CVRs for each Metabasis share. The fair values of the CVRs are remeasured at each reporting date through the term of the related agreement. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Any change in fair value is recorded in our consolidated statement of operations. For additional information, see &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (4), Fair Value Measurement and Note (7), Balance Sheet Account Details</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#8221; &#160;&#160;</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:GoodwillAndIntangibleAssetsGoodwillPolicy" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY2_ab83dbbf-4a4c-4a0f-a3e8-816608f85610" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill, Intangible Assets and Other Long-Lived Assets</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if an event occurs indicating the potential for impairment. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than the carrying amount, including goodwill. We operate in one reporting unit. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair value of our reporting unit is less than the carrying amount, then no additional assessment is deemed necessary. Otherwise, we proceed to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with the carrying value, including goodwill. If the carrying amount of the reporting unit exceeds the fair value, the second step of the goodwill impairment test is performed to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. We may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. We performed the annual assessment for goodwill impairment during the fourth quarter of 2018, noting no impairment. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our identifiable intangible assets are typically composed of&#160;acquired core technologies, licensed technologies, customer relationships and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets&#8217; respective estimated useful lives. We regularly perform reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows, and the pattern of utilization of a particular asset.</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:CommercialLicenseRightsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY3_eba0a98e-90dc-4bbc-8c9b-44f6d3b7a23f" continuedAt="i8db7a8878e5f4954a8ec7aa81891de65" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Commercial license rights</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:ScheduleofCommercialLicenseRightsTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDc_0a186723-8f3a-4557-828e-10a58286afc4" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights consist of the following (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"></td><td style="width:71.893805%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.537463%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.684366%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, </span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo &amp; CorMatrix</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i06d7e832be914ea4927e544711c5f918_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzItMS0xLTEtMA_142d3660-2428-4b48-ac2a-200afaf4b5ce">17,696</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1714ac5410ad49d586a22807a601a7c8_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzItMy0xLTEtMA_f2189241-5da3-4eba-9c11-a1afc374bff1">17,696</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b15f9f5711d44a591a3a36a58b9681a_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMS0xLTEtMjA4MA_cb310c8b-3d43-4f81-96d6-b5a8c4afe86b">10,000</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if37a84377d584e49a64fd37c3dc17dfb_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMy0xLTEtMjEwMA_c8b6fccc-46d7-4341-a1ce-d92fffae1cf8">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6a92d032fd254b68a22e68edb0bb484e_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMS0xLTEtMA_8b7a32d1-9d17-4ec2-8398-c4ddfc9cb9d4">8,602</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iea65327226544655a478dc62c46f5a1e_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMy0xLTEtMA_64d097ab-43ef-49d2-b74b-d3b8d605bcb2">8,602</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzQtMS0xLTEtMA_b05e053e-4874-4efa-a3da-2fc43368d0d8">36,298</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzQtMy0xLTEtMA_6300ad5a-dc9a-4683-917d-a41699e670b3">26,298</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less: accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzUtMS0xLTEtMA_2f6462f3-3af8-488a-ab91-3f836b05ed09">4,838</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzUtMy0xLTEtMA_bc57fe84-8d1a-4f06-8c12-b78f494b7ae7">6,772</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total commercial license rights, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzYtMS0xLTEtMA_fafa48e0-d741-401e-b115-f76d65019d76">31,460</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzYtMy0xLTEtMA_26204dc5-b09c-43d8-8f97-0556966615bb">19,526</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric></ix:nonNumeric></ix:continuation><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">57</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i6f7edecce6e94e2b974d3d10fac5964a" continuedAt="i791aecf109664ee0b22f5b78fa718981"><ix:continuation id="i8db7a8878e5f4954a8ec7aa81891de65"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights represent a portfolio of future milestone and royalty payment rights acquired from Selexis in April 2013 and April 2015, CorMatrix in May 2016, and Pavella in December 2018. Individual commercial license rights acquired are accounted for as financial assets further discussed below. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In December 2018, we entered into a development funding and royalties agreement with Palvella.&#160;Pursuant to the agreement, we will receive up to $<ix:nonFraction unitRef="usd" contextRef="ib3eda2c10c4048a7aa0bacbfdfdfbc14_I20181231" decimals="INF" format="ixt:numdotdecimal" name="lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE2OTg_279ef0b2-e722-41e8-9a18-032b406b931d">8.0</ix:nonFraction> million of milestone payments upon the achievement by&#160;Palvella of certain regulatory milestones for PTX-022, a&#160;product candidate being developed to treat pachyonychia congentia, and corporate and financing milestones. In addition to the milestone payments,&#160;Palvella will pay us&#160;tiered royalties from <ix:nonFraction unitRef="number" contextRef="i8d095d9391b44d2a86b19f26283e7dc2_I20181231" decimals="INF" name="lgnd:ProductRoyaltyPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzMg_641707bc-7661-4983-b19c-161135a5fb4d">5.0</ix:nonFraction>% to <ix:nonFraction unitRef="number" contextRef="i9de660fb7aac4b88a7f3df2f717fed6d_I20181231" decimals="INF" name="lgnd:ProductRoyaltyPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzNQ_d122ea2a-e408-4f19-836e-6e5a3bfd057b">9.8</ix:nonFraction>% based on aggregate annual worldwide net sales of any PTX-022 products, if&#160;approved, subject to Palvella&#8217;s right to reduce the royalty rates by making payments in certain circumstances. We paid Palvella an upfront payment of $<ix:nonFraction unitRef="usd" contextRef="i1b15f9f5711d44a591a3a36a58b9681a_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3MTY_cb310c8b-3d43-4f81-96d6-b5a8c4afe86b">10.0</ix:nonFraction> million, which Palvella is required to use to fund the development of PTX-022. We will not incur any expenses to develop or commercialize PTX-022. Our director,&#160;Todd Davis, is also a director of Palvella, who beneficially owns <ix:nonFraction unitRef="number" contextRef="i41125f6764344dc486a91d878d152ad5_D20180101-20181231" decimals="2" name="lgnd:OwnershipInEntityByDirectorPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3MzU_9681a58c-c1c1-4e62-9971-b7fc346b5eaf">2</ix:nonFraction>% of Palvella's outstanding equity. Mr. Davis recused himself from all of the board's consideration of the purchase agreement between us and Palvella, including any financial analysis, the terms of the purchase agreement and the vote to approve the purchase agreement and the related transactions.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2017, we entered into a royalty agreement with Aziyo pursuant to which we will receive royalties from certain marketed products that Aziyo acquired from CorMatrix. Pursuant to the agreement, we received $<ix:nonFraction unitRef="usd" contextRef="i4399b7aa92d94af1af9043d8910747e6_D20170101-20171231" decimals="-6" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromRoyaltiesReceived" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEyNjE5_5edf0775-d46d-4d18-b4db-5a0ff8712926">10.0</ix:nonFraction> million in 2017 from Aziyo to buydown the royalty rates on the products CorMatrix sold to Aziyo. The agreement closed on May 31, 2017, in connection with the closing of the asset sale from CorMatrix to Aziyo (the &#8220;CorMatrix Asset Sale&#8221;). Per the agreement, we will receive a <ix:nonFraction unitRef="number" contextRef="i7fc73450defc41569175c47bffd04a31_I20181231" decimals="INF" name="lgnd:ProductRoyaltyPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEyOTIy_25e08cd2-f64c-431f-b6ec-b29af8f370bf">5</ix:nonFraction>% royalty on the products Aziyo acquired in the CorMatrix Asset Sale, reduced from the original <ix:nonFraction unitRef="number" contextRef="i35202cb30da54ce3b43396a39f8f50fd_I20160503" decimals="INF" name="lgnd:ProductRoyaltyPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzMDE5_f9545a76-bffd-4f39-b1c9-3973a2936e07">20</ix:nonFraction>% royalty from CorMatrix pursuant to the previously disclosed interest purchase agreement, dated May 3, 2016 (the &#8220;Original Interest Purchase Agreement&#8221;) between CorMatrix and us. In addition, Aziyo has agreed to pay us up to $<ix:nonFraction unitRef="usd" contextRef="i7fc73450defc41569175c47bffd04a31_I20181231" decimals="INF" format="ixt:numdotdecimal" name="lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzMjY0_ec6e38c8-cba3-4b03-8a5e-a0c26685deb9">10.0</ix:nonFraction> million of additional milestones tied to cumulative net sales of the products Aziyo acquired in the CorMatrix Asset Sale and to extend the term on these royalties by one year. The royalty agreement will terminate on May 31, 2027. In addition, in May 2017, we entered into an amended and restated interest purchase agreement (the &#8220;Amended Interest Purchase Agreement&#8221;) with CorMatrix, which supersedes in its entirety the Original Interest Purchase Agreement. Other than removing the commercial products sold to Aziyo in the CorMatrix Sale, the terms of the Amended Interest Purchase Agreement remain unchanged with respect to the CorMatrix developmental pipeline products, including the royalty rate of <ix:nonFraction unitRef="number" contextRef="i9ba7c91a27af4a8b9cc9746e85a2d4d0_I20181231" decimals="INF" name="lgnd:ProductRoyaltyPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzOTcx_71d1ed9a-5345-4114-bc99-1d696a8c6554">5</ix:nonFraction>% on such pipeline products. The Amended Interest Purchase Agreement will terminate <ix:nonNumeric contextRef="i7549ea636c7549ba8a48714cecadea82_D20180101-20181231" format="ixt-sec:duryear" name="lgnd:RoyaltyAgreementExpirationPeriod" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE0MDU2_3e49a473-0b79-493f-ade1-f77377142d9e">10</ix:nonNumeric> years from the date of the first commercial sale of such products. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for the Aziyo commercial license right as a financial asset in accordance with ASC 310 and amortize the commercial license right using the&#160;effective interest method whereby we forecast expected cash flows over the term of the arrangement to arrive at an annualized effective interest. The annual effective interest associated with the forecasted cash flows from the royalty agreement with Aziyo as of December 31, 2018 is <ix:nonFraction unitRef="number" contextRef="ib11ae4f07611449daceda5854c74bb9c_D20180101-20181231" decimals="2" name="lgnd:ForecastedCashFlowsEffectiveInterestRatePercent" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE0NTgw_31fdd97a-9e0c-46ef-b8f8-790e7134bca0">26</ix:nonFraction>%. Revenue is calculated by multiplying the carrying value of the commercial license right by the effective interest. The payments received in 2018 were accordingly allocated between revenue and the amortization of the commercial license rights.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We elected a prospective approach to account for changes in estimated cash flows and selected a method for determining when an impairment would be recognized and how to measure that impairment. In circumstances where our new estimate of expected cash flows is greater than previously expected, we will update our yield prospectively. While it has not occurred to date, in circumstances where our new estimate of expected cash flows is less than previously expected and below our original estimated yield we will record an impairment. Impairment will be recognized by reducing the financial asset to an amount that represents the present value of our most recent estimate of expected cash flows discounted by the original effective interest rate.&#160; In circumstances where our new estimate of expected cash flows is less than previously expected, but not below our original estimated yield, we will update our yield prospectively.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for commercial license rights related to developmental pipeline products on a non-accrual basis. These developmental pipeline products are non-commercialized, non-approved products that require FDA or other regulatory approval, and thus have uncertain cash flows. The developmental pipeline products are on a non-accrual basis as we are not yet able to forecast future cash flows given their pre-commercial stages of development. We will prospectively update the yield model under the effective interest method once the underlying products are commercialized and we can reliably forecast expected cash flows. Income will be calculated by multiplying the carrying value of the commercial license right by the effective interest rate.</span></div></ix:continuation><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:RevenueFromContractWithCustomerPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDg_c356e7b8-8fb5-48cc-80c9-ad092924eaab" continuedAt="iadb2871880fd4c9b86b9b529a187b13b" escape="true"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Revenue Recognition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our revenue is generated primarily from royalties on sales of products commercialized by our partners, Captisol material sales, license fees and development, regulatory and sales based milestone payments.</span></div></ix:nonNumeric></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">58</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i791aecf109664ee0b22f5b78fa718981" continuedAt="iee2b3f1f9420445db9f23be4bd997092"><ix:continuation id="iadb2871880fd4c9b86b9b529a187b13b" continuedAt="iab1183ca801c4e7abae4d31986f91fe2"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 1, 2018, we adopted ASC 606 which amends the guidance for recognition of revenue from contracts with customers by using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. The results for reporting periods beginning January 1, 2018, are presented in accordance with the new standard, although comparative information has not been restated and continues to be reported under the accounting standards and policies in effect for those periods. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Upon adoption, we recorded a net decrease of&#160;$<ix:nonFraction unitRef="usd" contextRef="if72b93facdb542d6b9aa3d2def1abd30_I20180101" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:RetainedEarningsAccumulatedDeficit" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzMA_2473fd64-a1f1-42cc-b32a-a35a8cd66715">25.6</ix:nonFraction> million to accumulated deficit due to the cumulative impact of adopting the new standard, with the impact related primarily to the acceleration of royalty revenue, net of related deferred tax impact. See additional information in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> subsection below. Our accounting policies under the new standard were applied prospectively and are noted below.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Royalties, License Fees and Milestones</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own&#160;under the&#160;contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment.  These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Material Sales</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize revenue when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The timing of revenue recognition, billings and cash collections results in billed accounts receivable, unbilled receivables (contract assets), and customer advances and deposits (contract liabilities) on the Consolidated Balance Sheet.  Except for royalty revenue, we generally receive payment at the point we satisfy our obligation or soon after.  Therefore, we do not generally carry a contract asset or deferred revenue balance.   </span></div></ix:continuation></ix:continuation><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">59</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="iee2b3f1f9420445db9f23be4bd997092" continuedAt="i2e3674b91a0f4cee8dea14e2940c5d47"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="iab1183ca801c4e7abae4d31986f91fe2">We have revenue sharing arrangements whereby certain revenue proceeds are shared with a third party.  The revenue standard requires an entity to determine whether it is a principal or an agent in these transactions by evaluating the nature of its promise to the customer. We received a $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:RevenueRecognitionMilestoneMethodMilestonePaymentReceived" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NDE_8d9d0272-82c6-4b7c-9900-5416d0b251a6">4.6</ix:nonFraction> million milestone payment from a license partner during 2018 of which $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NjA_f072c440-ce51-4acf-a31c-6f8e77a21bbc">3.0</ix:nonFraction> million was paid to a third-party in-licensor. We recorded net revenue of $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ContractWithCustomerLiabilityRevenueRecognized" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NzE_a8302161-d691-41e3-8192-49debe3bf02b">1.6</ix:nonFraction> million as we believe we are an agent in the transaction. We record amounts due to third-party in-licensors as general and administrative expenses when we are the principal in the transaction.</ix:continuation> </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Disaggregation of Revenue </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under ASC 605, the legacy revenue standard, we would have reported total royalty revenue of $<ix:nonFraction unitRef="usd" contextRef="ic47989b86a534d43a5bfc32cf62712d3_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA3NDQ_abc4e551-cd83-4b8b-b85d-f38feae22c6b">121.0</ix:nonFraction>&#160;million&#160;during 2018, disaggregated as follows: Promacta $<ix:nonFraction unitRef="usd" contextRef="i60f3b04793a34fca8e8b2fc0fd8651db_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA3Nzk_3d396a58-58bd-4454-8c86-d6378ad05d4c">92.3</ix:nonFraction>&#160;million, Kyprolis&#160;$<ix:nonFraction unitRef="usd" contextRef="i1c77c0695f9f4bc39202a1ee3b68fe5b_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4MTA_4b3fddd2-956c-4499-8cdf-6893afb6e3ef">20.9</ix:nonFraction>&#160;million, Evomela $<ix:nonFraction unitRef="usd" contextRef="i15a3fcbde8c3460cb635412e65ed0c9c_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4NDM_f8698ad2-932e-4f22-8d13-46bacc59fb7b">5.7</ix:nonFraction>&#160;million, and Other $<ix:nonFraction unitRef="usd" contextRef="i9ae47d774632454eacbfe62e6c31f927_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4Njc_0b4cd19a-3398-44b9-8f63-5d771b972bf9">2.1</ix:nonFraction>&#160;million. During 2017, royalty revenue continued to be reported in accordance with ASC 605 and was $<ix:nonFraction unitRef="usd" contextRef="i8689e4eec8504099bab348e57f6a9828_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4OTE_d38686ae-2b18-420c-a7d0-a861e03b4e38">88.7</ix:nonFraction> million&#160;or disaggregated as follows: Promacta $<ix:nonFraction unitRef="usd" contextRef="i8a17769dfb7942a285a0d743e736cb10_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5MDg_947e2f93-2c02-459e-b989-cdfd863626af">62.9</ix:nonFraction> million, Kyprolis $<ix:nonFraction unitRef="usd" contextRef="ib8aea3ed0ca949ac8970d2f8fe87f5bf_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5MjU_6c737702-7cdc-411d-b3c8-0dc838c880c4">16.4</ix:nonFraction> million, Evomela $<ix:nonFraction unitRef="usd" contextRef="i57170c9749ff46cb9f3837ec92589b71_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NDI_639e57ae-7ba8-4dd1-9330-3a19e5355174">7.2</ix:nonFraction> million and Other&#160;$<ix:nonFraction unitRef="usd" contextRef="ia775da1fbd8a416c8effcacdb92628e3_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NTk_b9c66c14-08cc-48a8-ab06-fb75a505102f">2.2</ix:nonFraction> million. During 2016, royalty revenue continued to be reported in accordance with ASC 605 and was $<ix:nonFraction unitRef="usd" contextRef="i18a21a167bc74581b1487f6c8625553e_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5OTY_291c6807-faab-4806-8001-7eb25322b361">59.4</ix:nonFraction> million&#160;or disaggregated as follows: Promacta $<ix:nonFraction unitRef="usd" contextRef="i719ef5c241d44dbd96e30c1fa3f49f12_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NzA_f5031fe4-f16d-416d-b46f-ef92e15d74a7">43.0</ix:nonFraction> million, Kyprolis $<ix:nonFraction unitRef="usd" contextRef="i1d061d85ca7a40dba5a324fbc7d0020f_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwMTQ_6aa586e4-217a-4f08-85f8-7f6c7784dcd8">12.1</ix:nonFraction> million, Evomela $<ix:nonFraction unitRef="usd" contextRef="i815a29c81959435e8d5fef20b9d28e7a_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwMzI_c87b8e16-c7c6-408a-b0ef-cbc7b8387c13">1.4</ix:nonFraction>&#160;million and Other $<ix:nonFraction unitRef="usd" contextRef="i26c94f297be24d6a90b411c3a92ab896_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwNTk_82ae6ffd-3ec4-454d-a06d-bcff8e1d874c">2.9</ix:nonFraction>&#160;million.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under ASC 606, royalty revenue was $<ix:nonFraction unitRef="usd" contextRef="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExNzY_6e7c9a7a-2518-4c15-9bde-de44a9658b7b">128.6</ix:nonFraction>&#160;million&#160;during 2018 or disaggregated as follows: Promacta $<ix:nonFraction unitRef="usd" contextRef="i07237780f1df476eab12d1e41646c600_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwODg_119e0ad2-11d1-4800-ab78-cb634fded25b">99.3</ix:nonFraction>&#160;million, Kyprolis $<ix:nonFraction unitRef="usd" contextRef="ia7034272bd6c43f6b5e9790c96dd349d_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExMTI_59d6c466-290e-4d98-8b32-b1e5d76368c4">21.7</ix:nonFraction>&#160;million, Evomela $<ix:nonFraction unitRef="usd" contextRef="ifeacc0dfa0ef409c9bf44db88ebbe700_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExMzY_8c12b825-ac4f-45e3-bf31-cab2639521f2">5.7</ix:nonFraction>&#160;million and Other $<ix:nonFraction unitRef="usd" contextRef="i305991a6fef5462c822324d86c4372dd_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExNjA_73ceffa1-a665-4e75-abf1-2dcc9048d074">1.9</ix:nonFraction>&#160;million.</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:DisaggregationOfRevenueTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NTA_4125f2fa-be75-4cdf-ab12-a8181f26b1ae" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands), which are not affected by the adoption of ASC 606:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.982456%;"><tr><td style="width:1.0%;"></td><td style="width:31.490566%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.428931%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:19.383648%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.900629%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:19.383648%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.428931%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:19.383648%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year ended December 31,&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material Sales&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Captisol&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtMi0xLTEtMzkzNw_51866514-d048-42c7-bae9-6233192016f2">29,123</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtNC0xLTEtMzkyMw_3aabff12-babf-4e5b-8040-cf4fb940a735">22,070</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtNi0xLTEtMzkyOA_6d308fc8-b491-440b-ae2f-a38a6da28eed">22,502</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones and other&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     License fees&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1d2a7464c56c40d39f92de328c3dd17e_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtMi0xLTEtMzk0NA_639b1cbe-7ac0-41c3-ad8d-94fc2bd21b52">78,195</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2534882e69ce43a6b613a1d083bfb3bd_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtNC0xLTEtMzkzMQ_8c0de5ec-79a5-473e-9047-d8745a738bb4">13,665</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4f60f855c1a14d8ab2bd47c786fc554e_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtNi0xLTEtMzkzNA_d38c22fc-0788-42e4-bff7-3f1e26e793fe">10,570</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Milestones&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie60c64b8008d42408987815303a30765_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtMi0xLTEtMzk0NA_eb911a56-aa82-4dc3-b60b-a18327e5b5d5">6,577</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia6e4af4ff3e0471097da34093a9ca62b_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtNC0xLTEtMzkzMQ_85628ef0-9d0f-443a-bde9-c8a305da068b">11,093</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icd3fbafcbe94483b8d0196d9163c3fdb_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtNi0xLTEtMzk0OA_d7a09a98-b066-49b1-a911-9fe2e0453a6a">16,091</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Other&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0313533c50f047899180474a41ba7930_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctMi0xLTEtMzk0NA_0155c0d1-7a9b-4943-94c3-09bec9f8bcd0">9,002</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i39dc95b331cd4a8faf8361f5540b8486_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctNC0xLTEtMzkzMQ_f4df443c-de3f-4c49-99ae-49f47bdbc992">5,589</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic8aa5f1c584f420aa7237defcce7252f_D20160101-20161231" decimals="-3" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctNi0xLTEtMzk0OA_56cca852-da5c-4e84-9b40-eb631ad9cb73">387</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtMi0xLTEtMzk1Nw_f12344dc-acc7-47ad-8772-3275fb3b7195">93,774</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtNC0xLTEtNzc4OA_cea28d8a-9d9f-4025-9d91-d0fac8fab0a1">30,347</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i827aa32e6966431f90040e4f23139fce_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtNi0xLTEtMzk2MA_4987d579-bcd7-4beb-be63-2e190642db02">27,048</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcw_c3c6c825-821c-4cad-8f04-9fcea18ea6d4" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Preclinical Study and Clinical Trial Accruals</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Substantial portions of our preclinical studies and all of our clinical trials have been performed by third-party laboratories, CROs.&#160;We account for a significant portion of&#160;the clinical study costs according to the terms of our contracts with CROs. The terms of the CRO contracts may result in payment flows that do not match the periods over which services are provided to us under such contracts. Our objective is to reflect the appropriate preclinical and clinical trial expenses in our financial statements in the same period as the services occur. As part of the process of preparing our financial statements, we rely on cost information provided by our CROs. We are also required to estimate certain of our expenses resulting from the obligations under the CRO contracts. Accordingly, our preclinical study and clinical trial accrual is dependent upon the timely and accurate reporting of CROs and other third-party vendors. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate as more information becomes available concerning changing circumstances, and conditions or events that may affect such estimates.&#160;No material adjustments to preclinical study and clinical trial accrued expenses have been recognized to date.</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ResearchAndDevelopmentExpensePolicy" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcx_98cacc4d-f1fd-4161-9ac4-185d3052479b" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Research and Development Expenses</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Research and development expense consists of labor, material, equipment, and allocated facilities costs of our scientific staff who are working pursuant to our collaborative agreements and other research and development projects. Also included in research and development expenses are third-party costs incurred for our research programs including in-licensing costs, CRO costs and costs incurred by other research and development service vendors. We expense these costs as they are incurred. When we make payments for research and development services prior to the services being rendered, we record those amounts as prepaid assets on our consolidated balance sheet and we expense them as the services are provided.</span></div></ix:nonNumeric></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">60</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i2e3674b91a0f4cee8dea14e2940c5d47" continuedAt="i255cd095fd824b688ec5a635e82b47fe"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ShareBasedCompensationOptionAndIncentivePlansPolicy" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzY1OTcwNjk4NzI3ODA_a479ba2f-9a45-4ee3-a730-1b0d9977929b" continuedAt="i4454aef95db44d8999a1a86d823b0be4" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share-Based Compensation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We incur share-based compensation expense related to restricted stock, ESPP, and stock options.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Restricted stock unit (RSU) and performance stock unit (PSU) are all considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. We recognize share-based compensation expense based on the fair value on a straight-line basis over the requisite service periods of the awards, taking into consideration of forfeitures. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we&#160;reassess the probability of the achievement of such corporate performance goals and any expense change resulting from an adjustment in the estimated shares to be released are treated as a cumulative catch-up in the period of adjustment.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We use the Black-Scholes-Merton option-pricing model to estimate the fair value of stock purchases under ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. We&#160;look to historical and implied volatilities of our stock to determine the expected volatility. The expected term of an award is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be <ix:nonFraction unitRef="number" contextRef="i6a68a109b1a44264b74ff24de2d81961_I20181231" decimals="2" name="us-gaap:EquitySecuritiesFvNiMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI2MDkx_d49e89df-cb32-4a1a-9e87-17aef8c45b1b">0</ix:nonFraction>% given that&#160;except for 2007, during which we declared a cash dividend on our common stock of $<ix:nonFraction unitRef="usdPerShare" contextRef="i4a0ce876e13c454b96f993d4d4ad5af9_D20070101-20071231" decimals="2" name="us-gaap:CommonStockDividendsPerShareDeclared" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjcwNzE_e3a41123-4caf-4fea-92d4-be00ccf72561">2.50</ix:nonFraction>&#160;per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future.&#160;The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We grant options,&#160;RSUs and PSUs to employees and non-employee directors. Non-employee directors are accounted for as employees. Options and RSUs granted to certain non-employee directors vest one year from the date of grant. Options granted to employees vest 1/8 on the six month anniversary of the date of grant, and 1/48 each month thereafter for forty-two months. RSUs and PSUs granted to employees vest over three years. All option awards generally expire <ix:nonNumeric contextRef="i6b500c2fbd5346e2a6d6116c3b290d3c_D20180101-20181231" format="ixt-sec:durwordsen" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI2ODky_3d6bd067-acd9-4c90-9505-62161fdf8289">ten years</ix:nonNumeric> from the date of grant.</span></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i4454aef95db44d8999a1a86d823b0be4">Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests.</ix:continuation> </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Derivatives</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2018, we issued $<ix:nonFraction unitRef="usd" contextRef="i8e9409e1ae334493b8b799a5136ed402_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyMw_ed256b4e-0db6-40d5-937b-73f4ff57f9f4">750.0</ix:nonFraction> million aggregate principal amount of&#160;2023 Notes, bearing cash interest at a rate of <ix:nonFraction unitRef="number" contextRef="i8e9409e1ae334493b8b799a5136ed402_I20181231" decimals="INF" name="us-gaap:DebtInstrumentInterestRateStatedPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyNw_a85ec64c-aadb-4b68-a7b0-32073a55ad66">0.75</ix:nonFraction>%&#160;per year, payable semi-annually, as further described&#160;in &#8220;Footnote 6. Convertible Senior Notes.&#8221; Concurrently with the issuance of the notes, we entered into a series of convertible note hedge&#160;and warrant transactions which in combination are designed to reduce the potential dilution to our stockholders and/or offset the cash&#160;payments we are required to make in excess of the principal amount upon conversion of the notes. The conversion option associated with&#160;the 2023 Notes temporarily met the criteria for an embedded derivative liability which required bifurcation and separate accounting. In&#160;addition, the note hedge and warrants were also temporarily classified as a derivative asset and liability, respectively, on our consolidated balance sheet. As a result of shareholder approval to increase the number of authorized shares of our common stock on June&#160;19, 2018, as discussed in &#8220;Footnote&#160;6. Convertible Senior Notes,&#8221; the derivative asset and liabilities were reclassified to additional paid-in&#160;capital. Changes in the fair value of these derivatives prior to being classified in equity were reflected in other expense, net, in our consolidated statements of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfDerivativeInstrumentsTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NTE_2b103abc-727d-4ea1-a68f-efe19c1c0781" continuedAt="i4528a7e6b8f44f41b2a627c09f713dae" escape="true">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the assets and the&#160;inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liabilities associated with the 2023 Notes:</ix:nonNumeric></span></div></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">61</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i255cd095fd824b688ec5a635e82b47fe" continuedAt="ice9e2e929a5545b9a20bffbf2f513e9c"><ix:continuation id="i4528a7e6b8f44f41b2a627c09f713dae"><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"></td><td style="width:51.698225%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.575148%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:21.076923%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.131361%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:18.118343%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of June 19, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="us-gaap:SharePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzEtMi0xLTEtNzgwOQ_6787366e-c524-4a7d-a6b8-a49301a63eff">187.09</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="id59bcc52dcb84716a983b5657976b3d8_I20180619" decimals="2" name="us-gaap:SharePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzEtNC0xLTEtNzgzNQ_4aee4833-0dc8-425e-a370-82bb82565dc2">195.91</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="lgnd:ExercisePriceofConvertibleBondHedge" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzItMi0xLTEtNzgxMQ_11dfa716-4555-45fd-a343-4f13c88693c8">248.48</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="id59bcc52dcb84716a983b5657976b3d8_I20180619" decimals="2" name="lgnd:ExercisePriceofConvertibleBondHedge" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzItNC0xLTEtNzgzMw_32c69030-9cc3-424e-a3f0-8572c9aee39b">248.48</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, warrant&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522" decimals="2" name="invest:InvestmentWarrantsExercisePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzMtMi0xLTEtNzgxMw_847971d6-8bb0-45ef-85df-87a5a5951a6d">315.38</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i07c0e2d53ab44177baafdb7c634d98df_D20180619-20180619" decimals="2" name="invest:InvestmentWarrantsExercisePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzMtNC0xLTEtNzgzMQ_cd6e6a4a-7a20-41cb-8613-8df3f3c15dd7">315.38</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="ie0bd90f3b36c43ff967e6b073bb482f5_I20180522" decimals="3" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzQtMi0xLTEtNzgxNQ_311bd50f-c253-43de-a5da-05902c169ac5">2.9</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="ie646486a057a4a24abd210fcf89ec5ac_I20180619" decimals="3" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzQtNC0xLTEtNzgyOQ_786f82a9-5274-47e4-844d-e9ceabfb6ad0">2.8</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i5528cc9246cd4cbf9e55a7081d960d09_I20180522" decimals="INF" format="ixt:zerodash" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzYtMi0xLTEtNzgxNw_24c1c84c-df46-4f50-8e49-fc42682d4705">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i36c8e54238ca4f048bcdea0102a51a07_I20180619" decimals="INF" format="ixt:zerodash" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzYtNC0xLTEtNzgyMw_9d7fe06f-9175-4a20-ac2d-c5918b3c3d9d">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="ie6b95d8edafe43388cdc0a5d870ca950_I20180522" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzctMi0xLTEtNzgxOQ_b58a0d54-adcc-4ec7-b0b3-ce281907be4e">0.75</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="icf8c60c7fdb64e0ba05e9b87d3d24fd7_I20180619" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzctNC0xLTEtNzgyNQ_1588524e-2f06-42c7-ac2d-482407e96001">0.75</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i68d6900fd0a8486397608f93ae2f2950_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzgtMi0xLTEtNzgyMQ_9dce3d22-1051-447c-a16a-43d652e13503">5.05</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i1ab3629dd4a84f25af6a6ed28fff01a6_I20180619" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzgtNC0xLTEtNzgyNw_fbc526e2-c272-470a-bcb3-85a4ed8abe50">4.98</ix:nonFraction>&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with our 2019 Notes, which we issued in August 2014 for $<ix:nonFraction unitRef="usd" contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjczOTU_530ba52d-a39f-44f7-8e97-c611a0808ec0">245.0</ix:nonFraction> million aggregate principal amount, on May 22, 2018, we amended it making an irrevocable election to settle the entire note in cash. As a result, we&#160;reclassified from equity to derivative liability the fair value of the conversion premium as of May 22, 2018. Amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the corresponding convertible bond hedge. As a result, we reclassified&#160;from equity to derivative asset the fair value of the bond hedge as of May 22, 2018. Changes in the fair value of these derivatives are&#160;reflected in other expense, net, in our condensed consolidated statements of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the derivative&#160;assets and the inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liability associated with the&#160;2019 Notes:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:51.812317%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.973021%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:19.554252%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.973021%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:20.287390%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of December 31, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522" decimals="2" name="us-gaap:SharePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzEtMi0xLTEtNzg1MQ_240d3887-b637-4b5e-b855-3a83f0082ffc">187.09</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="i788db1d002a24118902ba114a1c848a8_I20181231" decimals="2" name="us-gaap:SharePrice" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzEtNC0xLTEtNzg1Mw_5d950e30-ec71-4ec5-850d-8c89fe3a2f84">135.70</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522" decimals="2" name="lgnd:ExercisePriceofConvertibleBondHedge" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzItMi0xLTEtNzg0OQ_da07c5e9-0ee4-4a53-9f83-4d219623d03f">75.05</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$<ix:nonFraction unitRef="usdPerShare" contextRef="i788db1d002a24118902ba114a1c848a8_I20181231" decimals="2" name="lgnd:ExercisePriceofConvertibleBondHedge" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzItNC0xLTEtNzg1MQ_f6402278-348e-4ca0-a7ca-740e722608a6">75.05</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i94bfc7a6eb3c4e7f8de61d82318efc87_I20180522" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzMtMi0xLTEtNzg0OQ_4e1e11a8-ae21-449a-8ad9-d82032fcbb19">2.47</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i4f4b2d2a5e634e08a972694ba181cfbf_I20181231" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzMtNC0xLTEtNzg0Nw_9cc9be84-79e4-4a94-9634-44ada0b39037">2.60</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="if82e065acc144b048906db168419d424_I20180522" decimals="INF" format="ixt:zerodash" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzUtMi0xLTEtNzg0NQ_2db71ad7-7c65-4448-a1d2-6c21fad30847">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="ibf06eb88f9114519b8566ae3991390c1_I20181231" decimals="INF" format="ixt:zerodash" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzUtNC0xLTEtNzg0NQ_2477e7d1-870f-482f-bad8-a2fe29683b7e">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i05c9c59e0a404b2384aa8481bfe4e0f8_I20180522" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzYtMi0xLTEtNzg0Mg_bdb5d606-76ac-4fc8-a55f-549a36ccc196">0.75</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="idc51ddeb3e934105a34f1deb7f263b29_I20181231" decimals="4" name="us-gaap:DerivativeLiabilityMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzYtNC0xLTEtNzgzOQ_01946e43-b5d5-440f-9010-1574d125ea3b">0.75</ix:nonFraction>%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="iab43107ea2de411d8ec195b05082d875_I20180522" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzctMi0xLTEtNzgzNw_e749ecee-3b34-4588-8c52-286dd8a2b9d6">1.25</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="number" contextRef="i7f9f95d1537a49879879507d3c5b2ba7_I20181231" decimals="2" name="us-gaap:DerivativeLiabilityMeasurementInput" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzctNC0xLTEtNzgzOQ_d3ff659e-00de-47b3-94a8-10d0a5ecb9df">0.63</ix:nonFraction>&#160;</span></td></tr></table></div></ix:continuation><div><span><br/></span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:IncomeTaxPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcz_064c9a7e-f1ba-4269-b288-3877602cdf52" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income Taxes</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize the impact of a tax position in the financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.</span></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:DiscontinuedOperationsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjc0_7e7a12b8-f9eb-40ae-a7b4-245df66d3862" continuedAt="i52ab3090757d416cb68c5d1bd47cd3fe" escape="true">Discontinued Operations</ix:nonNumeric></span></div></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">62</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ice9e2e929a5545b9a20bffbf2f513e9c" continuedAt="if37a3c7b20a44da3b5f6be7ca4306bc5"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i52ab3090757d416cb68c5d1bd47cd3fe">In 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel.</ix:continuation> During the year ended December 31, 2016 we recognized a $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:GainLossOnSaleOfBusiness" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI5MzQy_80892b82-d288-47b9-b35c-384538d7f9f7">1.1</ix:nonFraction> million gain due to subsequent changes in certain estimates and liabilities previously recorded.  We recorded a provision for income taxes related to the gain of $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI5NDk5_8766abff-fe5e-4b1c-aa7b-49a5602a5edc">0.4</ix:nonFraction> million.</span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:EarningsPerSharePolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDU_e71a4a2d-3ffb-479f-80f1-5a2405392162" escape="true"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income (loss) Per Share</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Basic income (loss) per share is calculated by dividing net income by the weighted-average number of common shares outstanding during the period. Diluted income per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares outstanding during the period.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Potentially dilutive common shares consist of shares issuable under 2019 and 2023 convertible senior notes, stock options and restricted stock. 2019 and 2023 convertible senior notes have a dilutive impact when the average market price of the Company&#8217;s common stock exceeds the applicable conversion price of the respective notes. It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion. In addition, post May 22, 2018, the 2019 Notes can only be settled in cash and therefore there will be no further impact on income (loss) per share of these notes. Potentially dilutive common shares from stock options and restricted stock are determined using the average share price for each period under the treasury stock method. In addition, the following amounts are assumed to be used to repurchase shares: proceeds from exercise of stock options and the average amount of unrecognized compensation expense for restricted stock.  In loss periods, basic net loss per share and diluted net loss per share are identical since the effect of otherwise dilutive potential common shares is anti-dilutive and therefore excluded</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDk_dfdfd003-3af6-4288-b34d-0f0eafdf53a1" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:61.343109%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.730205%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.533138%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.730205%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.533138%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.730205%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares outstanding:</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItMS0xLTEtMA_eacb2c3a-f19d-47f9-bbf1-14763368636a">21,160</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItMy0xLTEtMA_66294cc1-4c08-4116-9987-df230a8839a8">21,032</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItNS0xLTEtMA_8e861108-7ca1-4c2c-9ad7-89c5d918e684">20,831</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dilutive potential common shares:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Restricted stock</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:WeightedAverageNumberOfSharesRestrictedStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtMS0xLTEtMA_308529ed-1f3e-4c8e-97f9-add32f57d819">72</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:WeightedAverageNumberOfSharesRestrictedStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtMy0xLTEtMA_790be9f7-ebae-47ce-bf2f-c24a024230dc">141</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:WeightedAverageNumberOfSharesRestrictedStock" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtNS0xLTEtMA_95cdefb4-bd42-4ec4-ab52-d9d1ed5d290c">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Stock options</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtMS0xLTEtMA_e5d980f0-230f-4491-af14-da5cb33958de">1,125</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtMy0xLTEtMA_231b912f-1f70-49e2-8520-ca23adac30bf">1,000</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtNS0xLTEtMA_026ff0a9-f5a1-4c3e-8ab4-112020981ea6">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Warrants associated with 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtMS0xLTEtMA_50148f78-9862-4d26-a16c-029a354af27c">1,017</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtMy0xLTEtMA_d58b1145-f299-4590-96a3-e1c318db8140">94</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtNS0xLTEtMA_0270d480-2337-44f7-a96b-046835431238">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   2019 Convertible Senior Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctMS0xLTEtMA_baefd9c3-0cba-4667-8658-ff66b23ac3e8">693</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctMy0xLTEtMA_f104d0e9-ff43-4fe3-a445-37da4c85a827">1,214</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctNS0xLTEtMA_066bb727-d9cf-40d7-a971-832c595ada5e">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares used to compute diluted income per share</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtMS0xLTEtMA_3388c69a-7883-4661-9fd2-c822abb13f3e">24,067</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtMy0xLTEtMA_44c35448-d081-4482-b60f-5f172e7964a7">23,481</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtNS0xLTEtMA_096af056-ee91-4e0d-bec8-a3048e99a897">20,831</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Potentially dilutive shares excluded from calculation due to anti-dilutive effect</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktMS0xLTEtMA_45d7ccf6-330d-441a-b96e-4294d065f6e2">2,845</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktMy0xLTEtMA_3ada5c2c-c1fa-4d34-b978-2c2ba9eb9419">335</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktNS0xLTEtMA_63b1440b-e1ae-4a21-a28b-962beba56930">3,544</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ComprehensiveIncomePolicyPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE2NDkyNjc1NTc2OTc_b52a8307-3eb0-4718-9eb9-c09f041a2237" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Comprehensive Income (Loss)</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Comprehensive income (loss) represents net income (loss) adjusted for the change during the periods presented in unrealized gains and losses on available-for-sale securities, foreign currency translation adjustments, and reclassification adjustments for realized gains or losses included in net income (loss). The unrealized gains or losses are reported on the Consolidated Statements of Comprehensive Income (Loss).</span></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE2NDkyNjc1NTc2OTg_18e39cba-eae0-42af-b710-a96af7a3283b" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Foreign Currency Translation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">The British Pound Sterling is the functional currency of Vernalis and the corresponding financial statements have been translated into U.S. Dollars in accordance with ASC 830-30, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">Translation of Financial Statements</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">. Assets and liabilities are translated at end-of-period rates while revenues and expenses are translated at average rates in effect during the period in which the activity took place. Equity is translated at historical rates and the resulting cumulative translation adjustments are included as a component of accumulated other comprehensive income (loss).</span></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjc5_8693c5be-c79a-43e6-bccd-636cbaa37bec" continuedAt="iba07d998f4e044a982352ace0b9743f5" escape="true">Accounting Standards Recently Adopted</ix:nonNumeric></span></div></ix:continuation><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">63</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="if37a3c7b20a44da3b5f6be7ca4306bc5" continuedAt="i49018b2c61cd48e79abeebfa0717be18"><ix:continuation id="iba07d998f4e044a982352ace0b9743f5" continuedAt="i4abb41b932564bcebd1b70bf072acdf3"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue Recognition </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In May 2014, the FASB issued new guidance related to revenue recognition, ASU 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10 and 2016-12, which outlines a comprehensive revenue recognition model and supersedes most current revenue recognition guidance. The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services. ASC 606 defines a five-step approach for recognizing revenue, which may require a company to use more judgment and make more estimates than under the current guidance. We adopted this new standard as of January 1, 2018, by using the modified-retrospective method. See </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Royalties</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Licenses Fees and Milestones</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Material Sales</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, and </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> subsections mentioned above for further information. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10), which requires equity investments (other than those accounted for under the equity method or those that result in consolidation) to be measured at fair value, with changes in fair value recognized in net income. We have strategic investments, including Viking, that fall under this guidance update. We have adopted ASU 2016-01 effective January 1, 2018 as a cumulative-effect adjustment and reclassified $<ix:nonFraction unitRef="usd" contextRef="if6d885e1e1c9488c9c8b980b72ab5539_I20180101" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyMA_432ec312-fd45-4888-b0ea-c8b9939ef441">2.7</ix:nonFraction> million unrealized gains on equity investments, net of tax, from accumulated other comprehensive income to accumulated deficit on our consolidated balance sheet. Effective January 1, 2018, our results of operations include the changes in fair value of these financial instruments. S</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">ee &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (2), Investment in Viking</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional information.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Stock Compensation</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;font-style:italic;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718), which aims to simplify the accounting for share-based payment transactions, including accounting for income taxes, classification on the statement of cash flows, accounting for forfeitures, and classification of awards as either liabilities or equity. We have adopted this standard effective January 1, 2017. This standard increases the volatility of net income by requiring excess tax benefits from share-based payment arrangements to be classified as discrete items within the provision for income taxes, rather than recognizing excess tax benefits in additional paid-in capital. Upon adoption in the first quarter of 2017, we recorded $<ix:nonFraction unitRef="usd" contextRef="ib96266c9cd9e42b68a5de54609fb51bd_I20170101" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI3NDg3NzkxOTUwNzY_d31eef75-2a01-4cac-a3a0-457b775d6b10">17.6</ix:nonFraction> million to accumulated deficit on our consolidated balance sheet, primarily related to unrealized tax benefits associated with share-based compensation. Also, as a result of the adoption of this new standard, we made an accounting policy election to recognize forfeitures as they occur and will no longer estimate expected forfeitures.&#160;In addition, excess income tax benefits from share-based compensation arrangements are classified as cash flows from operations, rather than cash flows from financing activities. We elected to apply the cash flows classification guidance prospectively and have not adjusted prior periods.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Statement of Cash Flows</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In August 2016 the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments. The new standard clarifies certain aspects of the statement of cash flows, and aims to reduce diversity in practice regarding how certain transactions are classified in the statement of cash flows. This standard was effective January 1, 2018. We adopted ASU 2016-15 effective January 1, 2018. For the year ended December 31, 2017, we have reclassed&#160;$<ix:nonFraction unitRef="usd" contextRef="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInInvestingActivities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0MTQ_4b7e9e0e-9aeb-4df8-9c8c-1200e3c68d5b">5.0</ix:nonFraction> million&#160;payments to CVR holders and other contingency payments from investing activities to operating activities. For the year ended December 31, 2016, we have reclassed $<ix:nonFraction unitRef="usd" contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInInvestingActivities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0MzI_ebb0981d-294b-41fc-b1f8-fb098ccded77">8.8</ix:nonFraction> million&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">payments to CVR holders and other contingency payments from investing activities to operating activities and financing activities in amount of $<ix:nonFraction unitRef="usd" contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInOperatingActivities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0NDk_6b83fc88-9f45-460d-8e36-e121d681fac7">2.3</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:NetCashProvidedByUsedInFinancingActivities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0NTY_ad90d5f2-d65d-42d6-a6ac-30564fcc06f4">6.5</ix:nonFraction> million, respectively.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#160;In addition, in November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230), Restricted Cash. The standard requires that a statement of cash flows explains the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, restricted cash should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The new guidance is effective for interim and annual periods beginning after December 15, 2017. We adopted this standard retrospectively, effective January 1, 2018 and included restricted cash amount of&#160;$<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:RestrictedCashCurrent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyNDU0Nw_ac056d5c-15b8-4f3f-b039-cc5522111700">2.6</ix:nonFraction> million, which was included in other current assets in our consolidated balance sheet as of December&#160;31, 2018, in the consolidated statement of cash flows. </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">See additional information in &#8220;Footnote 7. Balance Sheet Account Details.&#8221;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">We did not have any restricted cash as of December&#160;31, 2017 and&#160;2016&#160;.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounting Standards Not Yet Adopted</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Leases</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This standard requires organizations that lease assets to recognize the assets and liabilities created by those leases. The standard also will require disclosures to help investors and other financial statement users better understand the amount, timing, and uncertainty of cash flows arising from leases. The ASU becomes effective for public companies for fiscal years and interim periods within those fiscal years, beginning after December 15, 2018. In 2018, the FASB issued guidance that provides an optional transition method for adoption of this standard, which allows organizations to initially apply the new requirements at the effective date, recognize a cumulative effect adjustment to the opening balance of retained earnings, and continue to apply the legacy guidance in ASC 840, Leases,</span></div></ix:continuation></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">64</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i49018b2c61cd48e79abeebfa0717be18"><ix:continuation id="i4abb41b932564bcebd1b70bf072acdf3"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> including its disclosure requirements, in the comparative periods presented. We adopted this standard on January 1, 2019 by applying&#160;this optional transition method. For leases with a term of 12 months or less, we elected to not recognize lease assets and lease liabilities and expense the leases over a straight-line basis for the term of those leases. The adoption of this standards update resulted in no material impact to our balance sheet, statement of operations, equity&#160;or cash flows.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. ASU 2016-13 is effective for us beginning in the first quarter of 2020, with early adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Fair Value Measurement</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement: Disclosure Framework&#8212; Changes to the Disclosure Requirements for Fair Value Measurement (Topic 820), which modifies the disclosure requirements on fair value measurements. ASU 2018-13 is effective for us beginning in the first quarter of 2020, with earlier adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We do not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on our consolidated financial statements or disclosures.</span></div></ix:continuation></ix:continuation><div style="text-indent:24pt;"><span><br/></span></div><div id="i_0_384"></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">2.  <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:VariableInterestEntityDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU4OTI_c2a80f7f-bf07-40c5-adde-7a20a668c3ff" continuedAt="i4db1429a178741d6a8547f34c8cb052a" escape="true">Investment in Viking</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i4db1429a178741d6a8547f34c8cb052a" continuedAt="i994ef9986fad4619be73d2b8fda1d16d"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our current ownership in Viking is approximately&#160;<ix:nonFraction unitRef="number" contextRef="i4f2d6682161c4d8580620d72aac72bec_D20180101-20181231" decimals="3" name="us-gaap:LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU0OTc1NTgzNTIyNg_2ac81b30-630c-4168-8490-c53a30ce2b53">8.8</ix:nonFraction>%&#160;and&#160;we account it as investment in an available-for-sale security&#160;due to the fact that 1) we do not have the ability to exercise significant&#160;influence over Viking,&#160;2) we are not involved in Viking's&#160;ongoing operations, and 3) Viking does not rely on us to provide technology products, expertise, support or services.&#160;Our investment in Viking is measured at fair value, with changes in fair value recognized in net income.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our ownership in Viking was <ix:nonFraction unitRef="number" contextRef="ia92a709872af454ba4a10e9e097a3942_I20171231" decimals="3" name="us-gaap:EquityMethodInvestmentOwnershipPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ1MjA_e28f113c-228e-4e4f-ae23-bc35b8d6ec23">17.6</ix:nonFraction>%&#160;and <ix:nonFraction unitRef="number" contextRef="i1495b46d310b40f39b5ba48f1a435973_I20161231" decimals="3" name="us-gaap:EquityMethodInvestmentOwnershipPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjE3Mjc_69d739de-bf50-46c7-b44d-473c6b163cba">30.3</ix:nonFraction>%&#160;as of December 31, 2017 and 2016, respectively. As a result of Viking's public stock offerings, we recorded a dilution gain of $<ix:nonFraction unitRef="usd" contextRef="ia6fd586e979f42b98e809e8789d74966_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseinEquityMethodInvestment" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ2NTc_136a9eb1-9df1-496d-815c-8760fae15414">2.7</ix:nonFraction> million and a dilution loss of $<ix:nonFraction unitRef="usd" contextRef="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="lgnd:IncreaseDecreaseinEquityMethodInvestment" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ2ODM_a9a56075-aacd-4e17-b9a4-225b2b9e16a1">10.7</ix:nonFraction> million for the years ended December 31, 2017 and 2016, respectively. These amounts were recognized in Loss from Viking in our consolidated statement of operations. Our equity ownership interest in Viking decreased during the first quarter of 2018 to approximately <ix:nonFraction unitRef="number" contextRef="i752433d6202a4b8d86205c212edea90e_D20180101-20180331" decimals="3" name="lgnd:VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxMTQ_becd3d32-6bc1-4dd5-9e84-2e2e798ef2a0">12.4</ix:nonFraction>% due to Viking's financing events in February 2018. As a result, in February 2018, we concluded that we did not exert significant influence over Viking and discontinued accounting for our investment in Viking under the equity method. Viking is considered a related party as we maintain a seat on Viking's board of directors.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ligand and&#160;Viking were previously parties to a Loan and Security Agreement, dated May 21, 2014 (as amended by the First&#160;Amendment to Loan and Security Agreement, dated April 8, 2015, and the Second Amendment to Loan and Security Agreement, dated&#160;January 22, 2016, the &#8220;Loan and Security Agreement&#8221;), pursuant to which we loaned $<ix:nonFraction unitRef="usd" contextRef="iaffe39f2d0954dbd80e0485f4618b93a_D20140501-20140531" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:VariableInterestEntityFinancialOrOtherSupportAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODc2Nzk_03577d64-5922-4552-bf90-cecf72daf1e4">2.5</ix:nonFraction> million to Viking. Such debt was&#160;evidenced by a Senior Convertible Promissory Note (the &#8220;Convertible Note&#8221;).&#160;Pursuant to the terms of the Loan and Security Agreement, upon the consummation of the Follow-On Public Offering on April 13,&#160;2016, Viking repaid us&#160;$<ix:nonFraction unitRef="usd" contextRef="i383f1359ee76425995b33bc12c23ab90_I20160131" decimals="-5" format="ixt:numdotdecimal" name="lgnd:NoteReceivableAmountDueUponTriggeringEvent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg4ODY_e6ee3c73-b92f-4c04-919f-ba88030f1495">1.5</ix:nonFraction> million, which payment was composed of&#160;$<ix:nonFraction unitRef="usd" contextRef="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromCollectionOfNotesReceivable" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg5MDM_b017d7ca-dfeb-42c0-a452-71ec5ef4866f">0.3</ix:nonFraction> million in cash, with the remaining balance paid&#160;in Viking&#8217;s equity securities, resulting in the issuance of <ix:nonFraction unitRef="shares" contextRef="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413" decimals="INF" format="ixt:numdotdecimal" name="lgnd:EquityMethodInvestmentSharesReceivedLicensingAgreement" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg5OTg_0f834d5e-2b64-4bed-afa1-c63214a0e565">960,000</ix:nonFraction> shares of common stock to us in the Follow-On Public&#160;Offering. Such payment was applied, first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal&#160;amount of the Convertible Note. On July 15, 2017, Viking repaid an additional $<ix:nonFraction unitRef="usd" contextRef="i8c3752abd1af4925883b62910e38900f_I20170715" decimals="-5" format="ixt:numdotdecimal" name="lgnd:NoteReceivableCashDueUponTriggeringEvent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODkwNjU_130c10f9-9c4c-4f3b-b42e-af8695636437">0.2</ix:nonFraction> million in cash. Such payment was applied,&#160;first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal amount of the Convertible Note. On&#160;May 23, 2018, the Convertible Note was repurchased in full by Viking for $<ix:nonFraction unitRef="usd" contextRef="i77dbc1a726434cedaf60137ef4ee8652_D20180523-20180523" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:OtherSignificantNoncashTransactionValueOfConsiderationReceived1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODkxMTU_9221b6aa-ac96-4776-a571-32f448c9d272">3.9</ix:nonFraction> million in cash. As of December 31, 2018, the Convertible Note and Loan and&#160;Security Agreement are no longer outstanding.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We also have outstanding warrants to purchase 1.5 million shares of Viking's common stock at an exercise price of $<ix:nonFraction unitRef="usdPerShare" contextRef="if138f3f9b2b74770a5cce6db84ab24b9_I20160430" decimals="2" name="us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjg5MDM_6b25efae-53a5-451a-a30e-3d6ec8124080">1.50</ix:nonFraction> per share. We recorded the warrants in other current assets in our consolidated balance sheets at fair value of $<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:WarrantsAndRightsOutstanding" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjI2NDc_ae68ed30-8413-45ce-9cef-a6f73f27bcfb">9.3</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:WarrantsAndRightsOutstanding" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjI2NjU_2185858f-3f85-46d3-9bff-37abb6d2a2c7">3.9</ix:nonFraction> million at December&#160;31, 2018 and 2017, respectively.&#160;For the years ended December&#160;31, 2018, 2017 and 2016, a gain of $<ix:nonFraction unitRef="usd" contextRef="ia743eb727a504f64a2e98f6fafd87f67_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:FairValueOptionChangesInFairValueGainLoss1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxNjk_f3491f93-8f62-4f2b-849c-90aba0693fbf">5.4</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i487a7d2c1cd749679482b85797456924_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:FairValueOptionChangesInFairValueGainLoss1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxNzM_858d640f-299b-4035-809b-60efc4e0b592">3.2</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="i07d723f5c7634c8f84df7f866754f3e9_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:FairValueOptionChangesInFairValueGainLoss1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxODA_17d475e9-4d3b-453c-a0d0-70d67e9a747b">0.3</ix:nonFraction> million on the fair market value of the warrants, respectively, was included within other income. See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (4), Fair Value Measurement.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Prior to the adoption of ASU 2016-01, we reviewed our investment in Viking on a regular basis and assess whether events, changes in circumstances or the passage of time, in management's judgment, indicate that a loss in the market value of the investment may be other than temporary. This might include, but would not necessarily be limited to, the period of time during which the carrying value of our investment is significantly above the observed market value, a deterioration in Viking's financial condition, or an adverse event relating to its lead clinical programs. </span></div></ix:continuation><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">65</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i994ef9986fad4619be73d2b8fda1d16d" continuedAt="i61b117cef727477095c8aa9094780bcc">Based on a sustained low Viking common stock unit price during the year ended December 31, 2016, we determined that an other than temporary decrease in the value of our investment in Viking had occurred. We wrote down the value of our&#160;investment in Viking to its estimated fair value which resulted in impairment charges of&#160;$<ix:nonFraction unitRef="usd" contextRef="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ImpairmentOfInvestments" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU3NTA_5f908c8f-3995-443d-a22d-fbb697d91c93">7.4</ix:nonFraction> million&#160;for the year ended December 31, 2016. </ix:continuation></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i61b117cef727477095c8aa9094780bcc">Subsequent to the adoption of ASU 2016-01, we no longer account for our investment in Viking under the equity method; instead, it&#160;is measured at fair value, with changes in fair value recognized in net income.</ix:continuation>&#160;</span></div><div><span><br/></span></div><div id="i_0_396"></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">3.  <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:BusinessCombinationDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE2NDkyNjc0NTc0MjY_cb8e19d0-eee7-4318-b72f-940e36ab2f33" continuedAt="i8cd9af615c384e2c9be075159b204dad" escape="true">Business Combinations</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i8cd9af615c384e2c9be075159b204dad" continuedAt="i4f97ca2c45f84e378ca8e70942a000f2"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">As set forth below, we completed three acquisitions from January 1, 2016 through December 31, 2018, and all were</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> accounted for as business combinations.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> We applied&#160;the acquisition method of accounting. Accordingly, we recorded the tangible and intangible assets acquired and liabilities assumed at their estimated fair values as of the applicable date of acquisition. For each acquisition, we did not incur any material&#160;acquisition&#160;related costs.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Vernalis Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In October 2018, we acquired Vernalis, a structure-based drug discovery biotechnology company for $<ix:nonFraction unitRef="usd" contextRef="i38901eeb0e374312bb0a645919532284_D20181001-20181031" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTgxNQ_cc9d5df8-49e8-44c5-b63e-682f84be2b84">43.0</ix:nonFraction> million, funded through cash on hand. The acquisition of Vernalis increases our overall portfolio of fully-funded programs. As&#160;Vernalis' operations are not considered material, pro forma information is not provided.</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231" name="us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE2NDkyNjc0NTc0Mjc_01f1362d-a164-4ad0-8852-b77d49867f5a" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preliminary allocation of the consideration&#160;was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:97.076023%;"><tr><td style="width:1.0%;"></td><td style="width:77.518072%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.481928%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash and cash equivalents&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzAtMS0xLTEtNDM1OQ_f13feb31-1333-4299-b142-33a7107cfd34">34,286</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzEtMS0xLTEtNDM1OQ_89991e6f-3c7d-4425-935b-ece6e67d7be5">2,836</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other assets&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzItMS0xLTEtNDM1OQ_8d01cd5d-1f64-436f-bd65-d77e258adcd9">6,383</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts payable and accrued liabilities&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzMtMS0xLTEtNDM1OQ_82e471a6-c882-4403-8bfe-e1f8b062452c">3,403</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring and product reserves&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RestructuringReserve" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzQtMS0xLTEtMTU1NDY_d6f65ef5-c90d-4126-afce-efdbae1b47d5">7,118</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzQtMS0xLTEtNDM1OQ_37e737c4-4942-4e0f-94d7-f9590917503c">746</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Intangibles assets with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzctMS0xLTEtNDM1OQ_ecc1ca84-a201-48b9-a896-aa8f131f59df">7,000</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzgtMS0xLTEtNDM1OQ_6ed9a10c-77d5-4292-968e-b9f8d4fd9e39">3,740</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzctMS0xLTEtODI1MQ_bbc0bf11-8e41-47da-be64-49335bcb5f6b">42,978</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None of the goodwill is deductible for tax purposes. The fair value of the core technologies were based on the discounted cash flow method that estimated the present value of the hypothetical royalty/milestone streams derived from the licensing of the related technologies.  These projected cash flows were discounted to present value using a discount rate of&#160;<ix:nonFraction unitRef="number" contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031" decimals="3" name="lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTY3Mw_2e93c5ff-70ea-45db-af1e-db8fbf232ce9">34.0</ix:nonFraction>%. The fair value of the core technology is being amortized on a straight-line basis over the weighted average estimated useful life of approximately <ix:nonNumeric contextRef="iaa145923f25048de937e04721b4c84da_D20181001-20181031" format="ixt-sec:durwordsen" name="us-gaap:FiniteLivedIntangibleAssetUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTgxMg_87e0d45f-8d7d-4c18-9750-921146b88f7d">nine years</ix:nonNumeric>.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The estimated fair values of assets acquired and liabilities assumed, including deferred tax assets and liabilities, purchased intangibles and deferred revenue are provisional. The accounting for these amounts falls within the measurement period and therefore we may adjust these provisional amounts to reflect new information obtained about facts and circumstances that existed as of the acquisition date.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Crystal Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On October 6, 2017, we acquired all of the assets and liabilities of Crystal. Crystal is a biotechnology company focused in avian genetics and the generation of fully-human therapeutic engineering of animals for the generation of fully-human therapeutic antibodies through its OmniChicken&#174; technology. Under the terms of the agreement, we were to pay Crystal selling shareholders $<ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ0Mw_c3433627-76e9-4e3b-b49e-ee530811abf3">27.2</ix:nonFraction> million in cash including a $<ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="INF" format="ixt:numdotdecimal" name="lgnd:WorkingCapitalAdjustment" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ2NA_e37820d8-ba95-48ab-a0ce-3404e22f610d">2.2</ix:nonFraction> million&#160;working capital adjustment, and up to an additional $<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzUzMg_80a05c2d-9d0e-4919-9a7e-80ee1b1ffc59">10.5</ix:nonFraction> million&#160;of cash consideration based on Crystal&#8217;s achievement of certain research and business milestones prior to December&#160;31, 2019. In addition, Crystal&#8217;s selling shareholders will receive <ix:nonFraction unitRef="number" contextRef="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006" decimals="INF" name="lgnd:RevenueRoyaltytoAcquireeShareholdersPercent" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzcwOQ_aa9d3a11-6082-4402-927d-ab87681afd3b">10</ix:nonFraction>% of revenues realized by Ligand above&#160;$<ix:nonFraction unitRef="usd" contextRef="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006" decimals="INF" format="ixt:numdotdecimal" name="lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzc0OQ_42bb4e42-aa73-46eb-bd66-c852546fee0d">15</ix:nonFraction> million between the closing date and December&#160;31, 2022 from&#160;existing collaboration agreements between Crystal and&#160;three&#160;of its collaborators, and Crystal&#8217;s selling shareholders will receive <ix:nonFraction unitRef="number" contextRef="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006" decimals="INF" name="lgnd:RevenueRoyaltytoAcquireeShareholdersPercent" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzkyNg_9a8b2733-cf61-46dc-8ad4-099cc9450e83">20</ix:nonFraction>% of revenues above&#160;$<ix:nonFraction unitRef="usd" contextRef="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006" decimals="INF" format="ixt:numdotdecimal" name="lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzk0Nw_65776488-cb30-4675-899d-29aaa6dd83dc">1.5</ix:nonFraction> million&#160;generated between the closing date and </span></div></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">66</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i4f97ca2c45f84e378ca8e70942a000f2" continuedAt="ia9c3f3cc2a184891aaa71bdc39cdf6a8"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> December&#160;31, 2022 pursuant to a <ix:nonFraction unitRef="numberofcollaborationagreements" contextRef="i57c56b2221e94885a3513e61361de5d2_I20171006" decimals="INF" format="ixt-sec:numwordsen" name="lgnd:NumberofCollaborationAgreements" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzEwMjE_ee2af603-79cb-4ea5-b362-3439aec45be0">four</ix:nonFraction>th existing collaboration agreement with a large pharmaceutical company. As of December&#160;31, 2018, $<ix:nonFraction unitRef="usd" contextRef="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:CashPayable" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzIxOTkwMjMyNzE4OTU_452f3c9a-4d33-430d-9907-b2a84115eb15">0.2</ix:nonFraction> million of the initial $<ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzExMjI_b081decf-35d2-45c7-a35e-a8995e258ffe">27.2</ix:nonFraction> million of cash consideration remained outstanding.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At the closing of the acquisition, we recorded an&#160;$<ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="-5" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzEyOTE_dc9f15b6-9897-480b-b4b4-edbdb8188e8c">8.4</ix:nonFraction> million contingent liability for amounts potentially due to Crystal shareholders. The initial fair value of the liability was determined using a probability weighted income approach incorporating the estimated future cash flows from potential milestones and revenue sharing. These cash flows were then discounted to present value using discount rates based on&#160;our estimated corporate credit rating, and averaged to approximately <ix:nonFraction unitRef="number" contextRef="i0a8ca3d45f2d43049621874687484bb9_I20171006" decimals="3" name="lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE3MjU_73132d54-b794-4fbb-b6e4-c00acf0ed01e">4.6</ix:nonFraction>%. Refer to </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note 4 Fair Value Measurement </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">for further discussion. The liability has been periodically assessed based on events and circumstances related to the underlying milestones, and any changes in fair value are recorded in our consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. There was no change in the fair value of the contingent liabilities from the initial valuation date to December&#160;31, 2018.</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231" name="lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjE_7b0e6001-5227-4c67-9fb2-bed8fe93363f" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The aggregate acquisition consideration was determined to be $<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzIzNDE_1a183270-8171-4028-a55a-fd078fb3b38f">35.7</ix:nonFraction> million, consisting of (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"></td><td style="width:77.411765%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.588235%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash paid to Crystal shareholders</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="-3" format="ixt:numdotdecimal" name="lgnd:CashPaidtoAcquireBusiness" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzAtMS0xLTEtMA_f72ea379-61f2-4a0e-b6c5-202da80f7200">26,877</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash payable to Crystal Shareholders</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="lgnd:CashPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzEtMS0xLTEtMA_fe57fda0-20ff-4e22-839e-209512abf3a3">336</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assumed liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzItMS0xLTEtMA_b034bfab-45a8-4a35-b0be-19d5cf0f1320">129</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of contingent consideration</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006" decimals="-3" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzMtMS0xLTEtMA_f64af588-a993-425f-a59c-edf0bbf8e520">8,401</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzQtMS0xLTEtMA_aeea9461-5b17-46fc-a821-a2c14089e20f">35,743</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:36pt;"><span><br/></span></div><ix:nonNumeric contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231" name="us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjI_a44e1845-7653-4460-ab33-dbbae67ab0bb" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:78.498534%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.501466%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzAtMS0xLTEtMA_e93302c3-70d1-4ee9-89ae-453c3b6c639f">224</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzEtMS0xLTEtMA_7fc170e9-ae10-4209-ad9d-6d5e17890df5">2,513</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzItMS0xLTEtMA_0f208af7-cb61-44d2-acc5-7063230a8e1f">201</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Property and equipment, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzMtMS0xLTEtMA_50995193-783f-4be3-a2d5-a62f45603843">589</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Current liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzQtMS0xLTEtMA_b0cc431f-3f1c-4f02-99e8-d89f3bab9c8e">354</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzUtMS0xLTEtMA_2e508c45-5d53-4d3a-b161-6380eb9754f6">4,624</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Deferred tax liabilities, net</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzYtMS0xLTEtMA_e50a67d5-ba28-4d28-848a-1ce2a0e2c057">9,503</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Intangible asset with finite life - core technology</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzctMS0xLTEtMA_a45e3b47-51b7-4731-8208-933b49767989">36,000</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzgtMS0xLTEtMA_0c318c04-8f1b-4cb3-811f-104703c0dc8a">10,697</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzktMS0xLTEtMA_0f92e8d9-6c05-41e6-a7f3-0d60d0070fe4">35,743</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The fair value of the core technology, or OmniChicken technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniChicken technology. These projected cash flows were discounted to present value using a discount rate of&#160;<ix:nonFraction unitRef="number" contextRef="i0a8ca3d45f2d43049621874687484bb9_I20171006" decimals="INF" name="lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzMzNTI_a3aedb6a-a977-4a99-a7e9-5c427abdbf4c">10.8</ix:nonFraction>%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of&#160;<ix:nonNumeric contextRef="ida162efcc0e64c3698e0382c9a821d87_D20171006-20171006" format="ixt-sec:duryear" name="us-gaap:FiniteLivedIntangibleAssetUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTY3MQ_bcb10ca9-d48a-4b87-9421-51556485ac29">20</ix:nonNumeric> years.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $<ix:nonFraction unitRef="usd" contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzM2MjI_2d43cf87-c012-47a9-985e-d566f1bff4ef">10.7</ix:nonFraction> million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to Crystal&#8217;s potential revenue growth from combining the Crystal and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">OMT Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 8, 2016, we acquired substantially all of the assets and liabilities of OMT. OMT is a biotechnology company engaged in the genetic engineering of animals for the generation of human therapeutic antibodies through its OmniAb&#174; technology. <ix:nonNumeric contextRef="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231" name="lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjM_bf51c8f4-a0d8-4c4a-99e0-7b8c7eaaf6a4" continuedAt="i8c63a066437547a9a96577187d0fd4f6" escape="true">The aggregate acquisition consideration was $<ix:nonFraction unitRef="usd" contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationConsiderationTransferred1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQyODg_5fee00d6-d35b-47ca-9b69-d794d1a80dc5">173.4</ix:nonFraction> million, consisting of (in thousands, except per share amounts):</ix:nonNumeric></span></div></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">67</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ia9c3f3cc2a184891aaa71bdc39cdf6a8"><div style="text-align:center;margin-bottom:6pt;"><ix:continuation id="i8c63a066437547a9a96577187d0fd4f6"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"></td><td style="width:77.411765%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:18.588235%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PaymentsToAcquireBusinessesGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzAtMS0xLTEtMA_961d6535-eedc-4d98-84e6-3ccead4c42e8">96,006</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Actual number of shares issued</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108" decimals="-3" name="us-gaap:BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzItMS0xLTEtMA_9c4bcdc1-f3ec-42f6-8163-5543f25e4923">790</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Multiplied by: Ligand closing share price on January 8, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="INF" name="us-gaap:SharePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzMtMS0xLTEtMA_3e3286c3-5ed4-403d-8be3-c91c8537f507">98</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzQtMS0xLTEtMA_0c1206b0-d480-4d8d-8f68-f3d7dcf20ccd">77,373</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzUtMS0xLTEtMA_771cd6a7-b9a4-4c40-81a1-aed5a14fbd6f">173,379</ix:nonFraction>&#160;</span></td></tr></table></ix:continuation></div><div style="text-indent:36pt;"><span><br/></span></div><ix:nonNumeric contextRef="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231" name="us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjQ_02715181-96e8-4b6d-a8bc-ee8699afe4d6" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:78.498534%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:17.501466%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzAtMS0xLTEtMA_ad9410aa-58a0-459c-9f22-9ce0f6ff7aa7">3,504</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzEtMS0xLTEtMA_f9f51db2-6ff8-4f2d-8215-7d10a4c78f91">5</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Income tax receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" name="lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzItMS0xLTEtMA_aedbfd69-8f20-4d73-8ecf-80b7864126ce">136</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzMtMS0xLTEtMA_532103cc-3976-4730-8065-97f02825e77c">1</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred tax liabilities, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzQtMS0xLTEtMA_f671af89-9cfd-4a7f-ade5-7e41337457fb">55,708</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Intangible asset with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzUtMS0xLTEtMA_ca3a2b69-3ec8-47da-ae7c-bf26c00c0ac9">167,000</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzYtMS0xLTEtMA_58c6d985-c311-4b1c-9907-fa82369a234d">1,528</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzctMS0xLTEtMA_834e55ea-da74-45bd-a2cb-0c7254566217">59,969</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzgtMS0xLTEtMA_ccd755ae-76bc-46b7-bbff-1971e585175a">173,379</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The fair value of the core technology, or OMT's OmniAb technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniAb technology. These projected cash flows were discounted to present value using a discount rate of <ix:nonFraction unitRef="number" contextRef="i1523a02160ea4340b895af4cbcc28c78_I20160108" decimals="INF" name="lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ4Mjk_d0f173ad-017b-42df-a8d7-9b375cf50978">15.5</ix:nonFraction>%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of <ix:nonNumeric contextRef="i17a78122d7374267a4ec43cb6b8f9235_D20160108-20160108" format="ixt-sec:duryear" name="us-gaap:FiniteLivedIntangibleAssetUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ5NTA_0fbe8918-7093-43cd-8847-1c33a71d06ff">20</ix:nonNumeric> years.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $<ix:nonFraction unitRef="usd" contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzUwOTk_20fe3bd7-de90-4e3a-a52f-848729221bac">60.0</ix:nonFraction> million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to OMT&#8217;s potential revenue growth from combining the OMT and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.</span></div></ix:continuation><div><span><br/></span></div><div id="i_0_408"></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">4. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:FinancialInstrumentsDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzUzNjg_b33d32e8-b6a8-461e-b554-125c330b352c" continuedAt="if6a83d2655744edb8abf2e5b9be4961b" escape="true">Fair Value Measurement</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="if6a83d2655744edb8abf2e5b9be4961b" continuedAt="i529fa60de14146a79fb1e5d5e7c9fcbc"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We measure certain financial assets and liabilities at fair value on a recurring basis.  Fair value is a market-based measurement that should be determined using assumptions that market participants would use in pricing an asset or liability. We establish a three-level hierarchy to prioritize the inputs used in measuring fair value. The levels are described in the below with level 1 having the highest priority and level 3 having the lowest:</span></div><div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 1 - Observable inputs such as quoted prices in active markets </span></div><div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 2 - Inputs other than the quoted prices in active markets that are observable either directly or indirectly </span></div><div style="padding-left:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 3 - Unobservable inputs in which there is little or no market data, which require the Company to develop its own assumptions</span></div></ix:continuation><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">68</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i529fa60de14146a79fb1e5d5e7c9fcbc" continuedAt="iba7d916af20f4eb9a601eefa2fd911ce"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzY1OTcwNjk3ODIyMDI_f0ec3c08-eac9-4976-b1e5-49ed1fb35a81" continuedAt="i77a203c06b4b44ddbffce526d4f9b973" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"></td><td style="width:45.128130%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2233588cfcdd4d1d8216daf3329f3545_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtMS0xLTEtMA_086595ac-7e11-4b38-8834-e529df3ab30e">647,408</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i22719832b06742dcae5a658d47223931_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtMy0xLTEtMA_232b379f-b13e-4191-89d7-c08169cb38db">47,517</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i754ca8ba8ad24cac9f16597b92a3ea5f_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtNS0xLTEtMA_e266eb17-2350-42a9-9f46-4062b4d50929">599,891</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib03a2af9f5d54545a7ec5a4137113457_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtNy0xLTEtMA_69ae73e3-5ebf-45eb-b120-ca0a763de070">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1908cb4c829d42b2844e3bb3f6368f63_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzUtMS0xLTEtODQ4NA_da9ef031-f1ac-4cb4-9b2a-3225e6e9a941">9,257</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i64f8a58aefc1411cafeabef5c6a7b1fd_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtMy0xLTEtMA_48618745-5789-49f4-ac67-25eec8167823">9,257</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie8c9c9e6cb294fdbb37cef5bce12b5c7_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtNS0xLTEtMA_95053b35-90b4-42e0-a0cf-596ab539bca6">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i36f2d5d73c464b0db83cc19d3975cda9_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtNy0xLTEtMA_77d81210-79ad-40f3-a393-2d7d1ede942d">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie7d6396714744e2880bfbeacc09c78a1_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctMS0xLTEtMA_c674f6ed-0312-4776-a121-591d8b7add03">656,665</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib357eeae00de4b2f9b1a22317457315f_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctMy0xLTEtMA_4089d048-367c-4744-9ef5-7828681565a1">56,774</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctNS0xLTEtMA_ff7734dc-4cc0-4ca8-b631-4e3ca845c97a">599,891</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctNy0xLTEtMA_04561385-2a2c-48fd-a2f1-aa56c0471e4a">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8dcdef9f22634f7090bf5d69fcdb1a55_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktMS0xLTEtMA_f024d6a7-96f8-4ac3-a83b-2f20ed26e0d9">6,477</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i337533b66aed409fbb551874229f75dc_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktMy0xLTEtMA_466e284c-ff90-4e3f-a6ed-b7bb15961960">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibd9630ec50374d25a30576be33a7d809_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktNS0xLTEtMA_1c2a52a1-71b6-4b3e-b549-109e9b1bc466">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac4562685c694e1aa2783376bb16c397_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktNy0xLTEtMA_f8e33190-f27e-48b0-bad6-8d54659f5002">6,477</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id099ffb3f70c4870880029056f3695be_I20181231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTEtMS0xLTA_9a4bf3df-3cd8-42e3-8372-f018a23dc1fb">514</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8eaac6d98c2544b09548e8e62b89c4c3_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTMtMS0xLTA_baa24add-dad9-4df1-9a69-16ac47431800">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic130ac71bf1e42c7b737b642085cce55_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTUtMS0xLTA_10ea0623-c177-4c51-8964-471d10a43fe8">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia4692046f93b4663b7e83e2a8a873af5_I20181231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTctMS0xLTA_68961c02-6fbd-4e54-859e-160e6cb57f3b">514</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibcf1b8f7afc644a7b9ad7768719336a8_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTEtMS0xLTA_3d44b052-5998-4c66-bc3b-94d57db0182c">5,551</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i57f18aa010824bad8480819ba46172f0_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTMtMS0xLTA_e0fe6bef-df5a-4b39-94fc-6cc403d7aba7">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if47ef23bd3e44c4993c4afa7d1be94c7_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTUtMS0xLTA_719a7850-fd67-466b-86db-2b2fd001637d">5,551</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ifcedb617c87e4dcb92d2c7b639fcd223_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTctMS0xLTA_a07b59ee-3317-4bdd-8899-a11515bb56f7">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0b5020617b024955ba56ec0766513aad_I20181231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTEtMS0xLTg0ODg_83a8029c-14f9-4cf9-8750-d12aabe30faf">199</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8c35be238f5f4799bbc1031e24efec68_I20181231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTMtMS0xLTA_2ca15e07-fbf9-4b27-9322-1785e6e15775">199</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i132a6a890ed4471ba8dcfb3ace9549a0_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTUtMS0xLTA_e5be5822-c5b6-4f95-aede-a2fc5000a76f">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i3069e6dc112c4ef2a9cf5ab7ee50048d_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTctMS0xLTA_84a1c286-4a45-4e13-af96-d838026b3321">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie7d6396714744e2880bfbeacc09c78a1_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTEtMS0xLTA_8da5aefe-05c2-4094-a667-c915208c45c3">12,741</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib357eeae00de4b2f9b1a22317457315f_I20181231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTMtMS0xLTA_91c532cb-08c7-4000-b8f1-9c35b8f0b142">199</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTUtMS0xLTA_18718adf-22b6-48af-9583-c09633a17c51">5,551</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTctMS0xLTA_6bc08190-e817-444f-983d-cc0f2b06ad67">6,991</ix:nonFraction>&#160;</span></td></tr></table></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"></td><td style="width:45.128130%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib61cc1114176418598c990b41c9592be_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtMS0xLTEtMA_ee87bffb-b725-459f-9e82-0a7ac4029d48">181,041</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2fe58c083e874cab83a78bcd827e2e5f_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtMy0xLTEtMA_2c6456f4-1b13-43a3-8287-813cbb9068b7">1,896</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1b4d2c43bec54742920bd9ad32b07e48_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtNS0xLTEtMA_ad8300c0-d67e-4f28-8ee7-2ee198e13f51">179,145</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i30473976e3b8481aa885bb1335a889ba_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtNy0xLTEtMA_08a9c200-534f-4364-ace9-6e090ea393de">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Note receivable Viking </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(2)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6012dd95b4ab4dde814d5a046166d09c_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtMS0xLTEtMA_d519d816-c6de-4f9a-bb63-0072047c312d">3,877</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1baadb28e8b3408fa30ff77e00eec512_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtMy0xLTEtMA_cd4108e8-5a17-4bcf-990b-c18ecac80e27">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1941637101594a8cabf4ba0b5e120f5e_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtNS0xLTEtMA_639cdbae-0e7f-4d40-9516-79ef1a023d96">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iee4b70d2241e4511bad0987b2b407f03_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtNy0xLTEtMA_bf8ef6d4-87b2-46c0-a273-14f288eacd8b">3,877</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie61370b969e74487b411b5a782a4d5a1_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtMS0xLTEtMA_2fca75a3-bdcf-4f13-9733-2b1c69761200">3,846</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8bfcb6d6abee4192bca4732758d746b7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtMy0xLTEtMA_c2a90a3b-17a8-4836-9564-cedba9138bb6">3,846</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ife3a9602a0cc4ec79c3b2bda40aa033e_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtNS0xLTEtMA_7934eed9-93df-43ea-a012-e05b9415fb91">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i62bcebfbe2964b9da317b06464c29f89_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtNy0xLTEtMA_4dadf3c8-1e17-41b9-b1f3-767751fd2471">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iee6fe34449294b25881d8dbef0b24b9a_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctMS0xLTEtMA_29cd49c8-12c2-4480-a425-f5d39040ccc5">188,764</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1c52c13365f3461ab55087c232b51f23_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctMy0xLTEtMA_21f15c36-4074-4930-84e7-66f318cd9e0a">5,742</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0061c212e5ce4c66940a7702790b784e_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctNS0xLTEtMA_e3b8882e-03bb-49f6-a163-787c74510d1f">179,145</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i570e675c9bf14c37b7f85f189f5c58ec_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AssetsFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctNy0xLTEtMA_35295f68-2b60-4f4e-a57a-b4be11ee55ae">3,877</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ae9df4c8cc94d689af9eb73b9a9fceb_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktMS0xLTEtMA_8f17d4dc-ac09-47ff-8264-798c6e20e7a7">8,401</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i221c7262300e453ebd7dc80f8dc71c46_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktMy0xLTEtMA_b5d9e3dd-2e4c-45d6-a4b9-6d0e1063965e">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i63575e7ad8594216a6892afca9a80932_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktNS0xLTEtMA_ebd355e4-b516-4c89-ad34-12e042656460">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i5c6283c43ebd4c50aa4fe656936d6b4b_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktNy0xLTEtMA_6c613d73-3c2e-4124-8307-d7b5ba48d85c">8,401</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia7a3efe3d1124d26b92d141e512095a0_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTEtMS0xLTA_f6ffba00-5edd-4e32-91fa-847556b0277d">1,589</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9bb6c8e4586348ad8838a58f65c26246_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTMtMS0xLTA_f522032f-3d2f-425a-a732-96fba30a3a6b">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6a51c585db8547f0acb66bf4eb5290b7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTUtMS0xLTA_b0143b91-4a78-4084-a6b5-66ed689adad2">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i929b0893ee4f41fba2a2db7c8914d4f5_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTctMS0xLTA_ffe5c25d-14f7-4368-8d8d-68faaf79852d">1,589</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0ad5f3f765e1490fa0521acd9849999d_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTEtMS0xLTg1MTA_fbe01524-9860-4368-924d-b3a93ffd1ae7">3,971</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i73c27a6035d749d5b1f296f7edb8ca72_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTMtMS0xLTg1MTI_98a7385b-98fe-4394-99b0-27cb8c2ce432">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic453e34dcee74d5d9343bfeb6edf1581_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTUtMS0xLTY0ODI_7f323acf-0a70-4bb9-a5e8-0d3411c4de29">3,971</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9a3fec8ff6854321a38379f92429618c_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTctMS0xLTg1MTY_fbb26a7d-0d70-408a-8311-d884521f3701">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i00244b874b5f4b12a47e76b73be3fabf_I20171231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTEtMS0xLTg1MTg_ac8c3b25-7257-46f9-a077-ed1db6460b3a">284</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i928d1de786ce437ebcfc3e3082b3f1b9_I20171231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTMtMS0xLTA_2e019586-be59-4d31-83a8-314c5faab896">284</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i107301a7878e4cf4938d9121959d04a0_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTUtMS0xLTA_0259c0cf-2c24-4a3b-bcd8-71f8b0f5987a">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0d5efee5821c41c0a5ea3977d0964f60_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTctMS0xLTA_468869c0-fdbd-433a-8606-1266defb4bc9">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iee6fe34449294b25881d8dbef0b24b9a_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTEtMS0xLTg1MjA_d3db051a-507c-4436-9e1c-41890a61bbab">14,245</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i1c52c13365f3461ab55087c232b51f23_I20171231" decimals="-3" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTMtMS0xLTg1MjI_1d755b44-0bf6-4d53-be3b-5c2420b221d8">284</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i0061c212e5ce4c66940a7702790b784e_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTUtMS0xLTg1MjQ_528fc59d-ad1d-42a1-8a32-c806a8214f49">3,971</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i570e675c9bf14c37b7f85f189f5c58ec_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LiabilitiesFairValueDisclosure" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTctMS0xLTg1MjY_920d5737-78a0-48cd-b948-936e7324618e">9,990</ix:nonFraction>&#160;</span></td></tr></table></div><div style="text-indent:36pt;"><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(1) Amounts Investments in equity securities (including investments in Viking), are classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities. Short-term investments in marketable securities with maturities greater than 90 days are classified as level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(2) The fair value of the Convertible Note receivable from Viking at&#160;December&#160;31, 2017&#160;approximated the book value since the contractual maturity date was within five months from the end of 2017, and there was no plan to extend the maturity date. The fair value at</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017 was determined using a probability weighted option pricing model. The fair value is subjective and is affected by certain significant input to the valuation model such as the estimated volatility of the common stock, which was estimated to be <ix:nonFraction unitRef="number" contextRef="ifa4d91631dbf46cc83d6a025d8915d6e_I20171231" decimals="2" name="us-gaap:AlternativeInvestmentMeasurementInput" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIwMjk_4b1d8937-1f6a-498c-b2dc-68d59a863f5f">75</ix:nonFraction>% at December&#160;31, 2017. Changes in these assumptions may materially affect the fair value estimate. For the years ended December&#160;31, 2018</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017, and December&#160;31, 2016, we reported an increase in the fair value of <ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyMDU_e8deb371-3063-4a35-bf3e-c165443b08b3">0.0</ix:nonFraction> million, an increase in the fair value of&#160;$<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyMzg_88461889-021a-40cc-9592-588186673faa">0.9</ix:nonFraction> million, and a decrease in the fair value of $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyNDY_c669aede-b005-4d5f-a8f5-34ec0303839e">0.2</ix:nonFraction> million, respectively in "Other, net" of the consolidated statement of operations.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;&#160;&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(3) Investment in warrants, which we received as a result of Viking&#8217;s partial repayment of the Viking note receivable and our purchase of Viking common stock and warrants in April 2016, is classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(4) The fair value of Crystal contingent liabilities was determined using a probability weighted income approach. Most of the contingent payments are based on development or regulatory milestones as defined in the merger agreement with Crystal. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates regarding the timing and probability of achievement of certain developmental and regulatory milestones. At </span></div></ix:nonNumeric></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">69</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="iba7d916af20f4eb9a601eefa2fd911ce"><ix:continuation id="i77a203c06b4b44ddbffce526d4f9b973"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"> December&#160;31, 2018, most of the development and regulatory milestones were estimated to be highly probable of being achieved in 2019. Changes in these estimates may materially affect the fair value. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(5) The fair value of CyDex contingent liabilities was determined based on the income approach. To the extent the estimated future income may vary significantly given the long-term nature of the estimate, we utilize a Monte Carlo model. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates of timing and probability of achievement of certain revenue thresholds and developmental and regulatory milestones&#160;which may be achieved and affect amounts owed to former license holders.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(6) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-&#946; agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $<ix:nonFraction unitRef="usd" contextRef="ib09e4721ddef410299f0bd0c417261ed_I20181231" decimals="-6" format="ixt:numdotdecimal" name="us-gaap:ContractWithCustomerAssetGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ0Nw_e7684d1b-17ef-4707-b37a-2a79341a148e">375.0</ix:nonFraction> million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a&#160;$<ix:nonFraction unitRef="usd" contextRef="icd248d584f1346b5b66dd780d1e9928a_I20181231" decimals="-6" format="ixt:numdotdecimal" name="us-gaap:ContractWithCustomerAssetGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ1MQ_7321d6c5-b145-4c2d-b57f-fcdc4dc6848f">10.0</ix:nonFraction> million payment upon initiation of a Phase 3 clinical trial. Another Metabasis drug development program, RVT-1502, has been outlicensed to Metavant. RVT-1502 is a novel, orally-bioavailable, small molecule, glucagon receptor antagonist or &#8220;GRA.&#8221; We may be entitled to up to $<ix:nonFraction unitRef="usd" contextRef="ice0efd7fd9d64d719b062c5b9df1406e_I20181231" decimals="-6" format="ixt:numdotdecimal" name="us-gaap:ContractWithCustomerAssetGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ1Mw_c1bcf13b-c5b8-4b51-a210-a8951262dced">529.0</ix:nonFraction> million in milestone payments and royalties.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(7) The liability for amounts owed to a former licensor is determined using quoted market prices in active markets for the underlying investment received from a partner, a portion of which is owed to a former licensor.</span></div></ix:continuation><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzY1OTcwNjk3ODIyMDY_59aa989a-670a-4f1e-be88-831519f5a326" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the level 3 financial instruments as of December&#160;31, 2018 is as follows (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:81.284457%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:14.715543%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzEtMS0xLTEtMA_068ed564-f195-45c8-9d4c-472fe5e3d8e4">3,877</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Cash payment received as repayment of note receivable</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzMtMS0xLTEtMA_64833e0c-1153-4e52-b808-9de725112759">3,877</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instrument assets as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzQtMS0xLTEtMA_ab877ed2-1f26-4a3d-94f2-e7181e00a806">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzctMS0xLTEtMA_53429ffe-61a3-41f2-98d6-353123fb2f2e">9,990</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to CVR holders and other contingency payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i921201b66b074388aa32f960d2db10cc_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzktMS0xLTEtMA_408bb3f8-3cfb-4b72-b162-bd18308028b3">1,025</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value adjustments to contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ice45c867198c4943b2d8c9ed9f84c1df_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzEwLTEtMS0xLTA_92a59a91-f2a2-4517-9d27-6b7d0ed698d9">1,974</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzExLTEtMS0xLTA_a79fd5c3-55fa-4b5f-8c99-899359881d5e">6,991</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-align:center;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Assets Measured on a Non-Recurring Basis</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We apply fair value techniques on a non-recurring basis associated with valuing potential impairment losses related to our&#160;goodwill,&#160;indefinite-lived intangible assets, long-lived assets, and equity investments.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We evaluate goodwill and indefinite-lived intangible assets annually for impairment and whenever circumstances occur indicating that&#160;goodwill might be impaired. We determine the fair value of our reporting unit based on a combination of inputs, including the market&#160;capitalization of Ligand, as well as Level 3 inputs such as discounted cash flows, which are not observable from the market, directly or indirectly. We determine the fair value of our indefinite-lived intangible assets using the income approach based on Level 3 inputs.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Other than certain indefinite-lived intangible asset, there were no impairment of our goodwill, indefinite-lived assets, or long-lived assets recorded during the three years ended December&#160;31, 2018,&#160;2017 and 2016.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Fair Value of Financial Instruments</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014 and May 2018, we issued the 2019 Notes and 2023 Notes, respectively. We use&#160;quoted market rates in an inactive market, which are classified as a Level 2 input, to estimate the current fair value of our 2019 and 2023 Notes. The carrying value of the notes does not reflect the market rate. See &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (6), Convertible Senior Notes</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional information related to the fair value.</span></div></ix:continuation><div id="i_0_420"></div><div style="margin-top:9pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">70</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">5.  <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:LeasesOfLesseeDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzk4OTU2MDQ2NTA2NDU_24173a19-1202-4ff0-8df7-b5392e64f34f" continuedAt="i315bb16e39e54f7a98392b1c862292e9" escape="true">Lease Obligations</ix:nonNumeric></span></div><ix:continuation id="i315bb16e39e54f7a98392b1c862292e9"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We lease office facilities&#160;under various operating leases. These leases expire between 2019 and 2023. Total rent expense, net under all office leases for 2018, 2017 and 2016 was $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:LeaseAndRentalExpense" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIwMg_7e6775ef-8ea0-44f7-8909-cea63d218403">1.0</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:LeaseAndRentalExpense" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIwNg_15f9936c-2d96-484e-9649-0785155fa4d8">0.3</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:LeaseAndRentalExpense" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIxMw_ff456935-0846-4ce2-86b6-79b42e149d44">0.3</ix:nonFraction> million, respectively.  <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzk4OTU2MDQ2NTA2NDY_d524c674-c821-4cd5-8dac-b63363f8acc3" continuedAt="i132f539424d14710b9513e53f1952b59" escape="true">The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of December&#160;31, 2018 (in thousands):</ix:nonNumeric></span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><ix:continuation id="i132f539424d14710b9513e53f1952b59"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"><tr><td style="width:1.0%;"></td><td style="width:39.679627%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.577605%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.975117%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.577605%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.975117%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.044168%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.797823%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:1.044168%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.108865%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.733126%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:7.486781%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Operating lease obligations:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Lease</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Termination</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Date</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Less than 1</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">year</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1-2 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3-4 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corporate headquarters - San Diego, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2023</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtNC0xLTEtMA_a50cf5be-db9f-47da-a4fa-d4e815c8c880">135</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtNi0xLTEtMA_4b57dcd5-9b30-48c5-bed4-01ffb02326f8">283</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtOC0xLTEtMA_1f5a031a-11ba-418f-9e85-490fde759093">198</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtMTItMS0xLTA_f6c4ee54-d14c-4cf2-912d-10b3e2d745ca">616</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItNC0xLTEtMA_0fc2be39-55bf-4bdb-808b-2273ae6e12d5">373</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" format="ixt:zerodash" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItOC0xLTEtMA_0bc70ceb-d0a5-4a56-ad56-540e8f8673bd">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItMTItMS0xLTA_882fef1b-7735-4e70-b393-d48a62119913">373</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Bioscience and Technology Business Center - Lawrence, KS</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 2020</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtNC0xLTEtMA_1021fc1c-6ddb-4957-afb2-8c3de16fd408">57</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtNi0xLTEtMA_3a5d2e8b-403e-42a8-8303-f5864ba9d859">56</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtMTItMS0xLTA_ad30661f-e0d0-4739-a216-3c64e9d4b52e">113</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Emeryville, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtNC0xLTEtMA_4f0c12cf-f192-4b13-921f-21cb6ae7d1de">260</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtNi0xLTEtMA_748b9109-7adc-4366-bf60-5eb07c20f72e">455</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtMTItMS0xLTA_747bb786-22e2-428b-9a5e-5c64caef7fbb">715</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Emeryville, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtNC0xLTEtMA_beba5cd2-d814-4a68-83f7-5c08df078576">203</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtNi0xLTEtMA_e6e1645c-5c4c-4309-87ac-4d2d9fee0f4a">351</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtMTItMS0xLTA_79d67a69-6109-4677-8c3e-6515a462d335">554</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Winnersh, United Kingdom</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i354c535302b44bb19e10fe3b5a010cc8_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNC0xLTEtODczMA_7ace3a5d-4d51-4d81-a802-ceb6f60d8c92">43</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i354c535302b44bb19e10fe3b5a010cc8_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtMTItMS0xLTg3Nzc_d677dc24-9417-4f06-b2f9-0b957cc14f70">43</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Cambridge, United Kingdom</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">September 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic340228d81314653a2c316604b50c401_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzctNC0xLTEtODc2MQ_ec4d2e0e-f970-434c-b869-f6b15c2ab3fa">549</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic340228d81314653a2c316604b50c401_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzctMTItMS0xLTg3Nzc_dbfb3fc6-7f6b-4d4a-9d7a-1f8eed770a4e">549</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNC0xLTEtMA_a686b334-33c4-4f9a-b58b-36c930e1c8f3">1,620</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNi0xLTEtMA_d78abf02-a0a1-4830-a020-6bcf00afaf2e">1,145</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtOC0xLTEtMA_5facbbbf-497f-4b45-9195-3c3ec0135d9f">198</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtMTItMS0xLTA_8fdc930c-7493-4271-af87-65b180a02586">2,963</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sublease payments expected to be received:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktNC0xLTEtMA_46070a89-a2d8-4dc5-a8c0-92e8cba6b7d6">360</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" format="ixt:zerodash" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktNi0xLTEtMA_d5aa0f0b-368c-4dd1-aac7-fb988ecfafe9">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" format="ixt:zerodash" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktOC0xLTEtMA_3c95a04d-bc0a-4db2-bdef-63510aea3269">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231" decimals="-3" name="us-gaap:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktMTItMS0xLTA_ba8cda3a-4cac-40fd-99bb-560ad1bf7055">360</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTQtMS0xLTA_1aace4de-47ed-4fae-b42d-1c54662cd2ba">1,260</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTYtMS0xLTA_9dd62981-cdb9-4829-b0de-adf884e4b39c">1,145</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTgtMS0xLTA_d5ad5192-a861-408e-8dba-a776f61d9799">198</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OperatingLeasesFutureMinimumPaymentsDueNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTEyLTEtMS0w_5cb166be-eec4-4dac-9781-d5c0814d3a76">2,603</ix:nonFraction>&#160;</span></td></tr></table></ix:continuation></div></ix:continuation><div><span><br/></span></div><div id="i_0_432"></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">6. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:DebtDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzkzNDU4NDg4NzAyMDE_c1594a84-1ec2-4363-becb-b91941ddb6d7" continuedAt="i2aaf5face3ad4aa3bf40bee625d826ae" escape="true">Convertible Senior Notes</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i2aaf5face3ad4aa3bf40bee625d826ae" continuedAt="ibe1fb0cd9eb4437cb6a088a7824cca04"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">0.75% Convertible Senior Notes&#160;due 2019</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014, we issued $<ix:nonFraction unitRef="usd" contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEwMQ_530ba52d-a39f-44f7-8e97-c611a0808ec0">245.0</ix:nonFraction> million aggregate principal amount of 2019&#160;Notes, resulting in net proceeds of $<ix:nonFraction unitRef="usd" contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromDebtNetOfIssuanceCosts" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzE5OA_47a03c04-0bc2-4097-af95-30e3486e67b1">239.3</ix:nonFraction> million. The implied estimated effective rate of the liability component of the 2019 Notes was <ix:nonFraction unitRef="number" contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831" decimals="4" name="us-gaap:DebtInstrumentInterestRateEffectivePercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ3Mg_3eaada82-03e8-488b-96b4-b24848a6850d">5.83</ix:nonFraction>%.&#160;The 2019 Notes are convertible into common stock at an initial conversion rate of 13.3251 shares per $1,000 principal amount of convertible notes, subject to adjustment upon certain events, which is equivalent to an initial conversion price of approximately $<ix:nonFraction unitRef="usdPerShare" contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831" decimals="2" name="us-gaap:DebtInstrumentConvertibleConversionPrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzQ3NQ_3aa6ca5a-7a4e-4bd7-96f2-814d76472a96">75.05</ix:nonFraction> per share of common stock. The notes bear cash interest at a rate of <ix:nonFraction unitRef="number" contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831" decimals="INF" name="us-gaap:DebtInstrumentInterestRateStatedPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OA_eb037d8f-121c-491e-a306-b742c2373986">0.75</ix:nonFraction>% per year, payable semi-annually. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Holders of the 2019 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding May 15, 2019, under any of the following circumstances: </span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) during any fiscal quarter (and only during such fiscal quarter) commencing after December&#160;31, 2014, if,</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">for at least <ix:nonFraction unitRef="trading_day" contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdTradingDays" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzkyMg_6485fcb7-bbcd-4a27-af04-217533f475ad">20</ix:nonFraction> trading days (whether or not consecutive) during the&#160;<ix:nonFraction unitRef="trading_day" contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzk4MA_78a0e30e-59c5-4882-a5a5-b8eb74491894">30</ix:nonFraction> consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than <ix:nonFraction unitRef="number" contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzExODU_d9da2c52-977c-482f-917d-1220c7b7b192">130</ix:nonFraction>% of the conversion price on such trading day; </span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(2) during the <ix:nonFraction unitRef="day" contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831" decimals="INF" format="ixt-sec:numwordsen" name="us-gaap:DebtInstrumentConvertibleThresholdTradingDays" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEyNTI_f1cba4ce-b10a-4edb-b773-22ead3ad5a6f">five</ix:nonFraction> business day period immediately following any&#160;<ix:nonFraction unitRef="trading_day" contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEzMDM_ca7e96f2-441f-48b2-a17a-d111e8424380">10</ix:nonFraction> consecutive trading day period, in which the trading price per $1,000 principal amount of notes was less than <ix:nonFraction unitRef="number" contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831" decimals="2" name="lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzE0MTY_1f1dcf3c-38da-444a-93db-874f48d46d8d">98</ix:nonFraction>% of the product of the last reported sale price of our common stock on such trading day and the conversion rate on each such trading day; or </span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes. </span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2017, our last reported sale price of our common stock exceeded the <ix:nonFraction unitRef="number" contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzYwNDczMTM5OTQwMTU_156b74eb-460a-4655-a664-486c186dac4b">130</ix:nonFraction>% threshold described above and accordingly&#160;the 2019&#160;Notes were classified as a current liability. As a result, the related unamortized&#160;discount of $<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzYwNDczMTM5OTQwMzU_d6d512a4-e688-494d-9a84-2da60f071861">18.9</ix:nonFraction> million&#160;at December 31, 2017, was classified as temporary equity component&#160;of currently redeemable convertible notes on our consolidated balance sheet.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2018, our 2019 Notes are due in less than one year, and accordingly have been&#160;classified as a current liability. Under the original indenture conversion, we were obligated to deliver cash to settle the principal and may&#160;deliver cash or shares of common stock, at our option, to settle any premium due upon conversion for any conversion notices received prior&#160;</span></div></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">71</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ibe1fb0cd9eb4437cb6a088a7824cca04" continuedAt="i2b2f655f71fc4bb288beac13f0f5ac00"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> to May 22, 2018. We made an irrevocable election to settle the entire&#160;note in cash&#160;per&#160;a supplemental indenture entered into on May 22, 2018. As such, we must deliver cash to settle the principal and any premium due upon conversion for any conversion notices&#160;received on or after May 22, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As a result of the requirement to deliver cash to settle any premium due upon conversion, on May 22, 2018, we reclassified from equity to liability the conversion option (a derivative) fair value of $<ix:nonFraction unitRef="usd" contextRef="ic6a1014c54c4494f865d0272345aab6a_D20180522-20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTM5Njk_cefd2382-9fbb-4cd3-be66-07908d5f7e22">341.6</ix:nonFraction> million. In accordance with ASC 815, Derivatives and Hedging, the derivative was adjusted to its fair value as of December 31, 2018 to $<ix:nonFraction unitRef="usd" contextRef="i69c23a1e2fbe4523a3ca4deec08a3872_D20181231-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTQwOTk_b1cfd10d-d00e-4ca4-9166-603bcebfa801">23.4</ix:nonFraction> million with the resulting $<ix:nonFraction unitRef="usd" contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTQxMjE_b1dad315-4370-4abc-9734-9981db2aaf0d">118.7</ix:nonFraction> million increase, net of payments made, reflected in other expense, net, in our consolidated statements of operations for the year ended December 31, 2018.  </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:10pt;line-height:115%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In March and April 2018, we received notices for conversion of $<ix:nonFraction unitRef="usd" contextRef="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtConversionConvertedInstrumentAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ0NQ_6c5c3d53-fa5f-4ba9-b85e-e6e892a1ee35">21.8</ix:nonFraction> million of principal amount of the 2019 Notes which were settled in&#160;May and June 2018. We paid the noteholders the conversion value of the notes in cash, up to the principal amount of the 2019 Notes. The&#160;excess of the conversion value over the principal amount, totaling&#160;$<ix:nonFraction unitRef="usd" contextRef="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ0OQ_c31eb8df-3908-483f-a026-83394652444a">31.6</ix:nonFraction> million, was paid in shares of common stock.&#160;In July and&#160;August 2018, we received notices for conversion of&#160;$<ix:nonFraction unitRef="usd" contextRef="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtConversionConvertedInstrumentAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1Mg_8a277d54-0e61-448c-bc78-8f17964face6">195.9</ix:nonFraction> million&#160;of principal amount of the 2019 Notes which were settled in October and November 2018. We paid the noteholders the&#160;$<ix:nonFraction unitRef="usd" contextRef="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtConversionConvertedInstrumentAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1NA_fec3ea8c-12a9-4f07-9a09-8cb75ecded73">195.9</ix:nonFraction> million&#160;principal amount and the excess of&#160;conversion value over the principal amount, totaling&#160;$<ix:nonFraction unitRef="usd" contextRef="i75f0350fef6541038e98f82afd43a2f1_D20181001-20181130" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1Nw_e919eb6c-8aa5-486e-9933-f19b5c3033c7">439.6</ix:nonFraction> million, in cash. The equity dilution and&#160;cash conversion premium payment&#160;upon conversion of the 2019 Notes was offset by the reacquisition of the shares and cash under the convertible bond hedge transactions entered into in connection with the offering of the 2019 Notes.&#160;As a result of the conversions, we recorded a&#160;$<ix:nonFraction unitRef="usd" contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:GainsLossesOnExtinguishmentOfDebt" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ2MQ_38fe1290-4cd2-4243-ba68-de45c334d4ab">3.2</ix:nonFraction> million loss on extinguishment of debt calculated as the difference between the estimated fair value of the debt and the carrying value of the 2019 Notes as of the settlement dates. To measure the fair value of the converted 2019 Notes as of the settlement dates, the applicable interest rates were estimated using Level 2 observable inputs and applied to the converted notes using the same methodology as in the issuance date valuation.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;&#160;</span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Convertible Bond Hedge and Warrant Transactions</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014, to minimize the impact of potential dilution to our common stock upon conversion of the 2019 Notes, we entered into convertible bond hedges and sold warrants covering <ix:nonFraction unitRef="shares" contextRef="i37074bf992d247a491292198d0359ff0_I20140831" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzY1MTk_04bf2962-2853-4d5b-8c91-4100db496405">3,264,643</ix:nonFraction> shares of our common stock. The convertible bond hedges have an exercise price of $<ix:nonFraction unitRef="usdPerShare" contextRef="i37074bf992d247a491292198d0359ff0_I20140831" decimals="INF" name="lgnd:ExercisePriceofConvertibleBondHedge" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzY2MDU_a680d519-d8cf-408d-a8f0-f6eafc957d83">75.05</ix:nonFraction> per share and are exercisable when and if the 2019 Notes are converted. If upon conversion of the 2019 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into by us and are not part of the terms of the 2019 Notes. Holders of the 2019 Notes and warrants will not have any rights with respect to the convertible bond hedges. We paid $<ix:nonFraction unitRef="usd" contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831" decimals="-5" format="ixt:numdotdecimal" name="lgnd:PaymentsforConvertibleBondHedges" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc1MTI_3f15e41b-fe6d-41e7-9070-b4eb6f6ac2ba">48.1</ix:nonFraction> million for these convertible bond hedges and recorded the amount as a reduction to additional paid-in capital.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Conversion notices received after May 22, 2018 relating to the 2019 Notes must be fully settled in cash and amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the convertible bond hedge. As a result of the irrevocable cash election, on&#160;May 22, 2018, we reclassified from equity to derivative asset the remaining bond hedge fair value of&#160;$<ix:nonFraction unitRef="usd" contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DerivativeAssetsCurrent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzNA_98dfdbd2-b476-473f-bfad-4f4f05c5e6f0">340.0</ix:nonFraction> million and marked it to&#160;market as of December 31, 2018 to&#160;$<ix:nonFraction unitRef="usd" contextRef="i788db1d002a24118902ba114a1c848a8_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DerivativeAssetsCurrent" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzNw_df39abc4-6cfe-479e-ad24-9067925f22f9">22.6</ix:nonFraction> million with the resulting $<ix:nonFraction unitRef="usd" contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DerivativeGainLossOnDerivativeNet" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzOQ_4229494a-9b09-47de-b9be-4fa43a26f7f5">119.4</ix:nonFraction> million&#160;increase, net of $<ix:nonFraction unitRef="usd" contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromDerivativeInstrumentInvestingActivities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzcxNDY4MjU2MTk3NjQ_45454035-e1a4-4b92-b65f-f01eb88f0653">471.2</ix:nonFraction> million in payments received, reflected in other expense,&#160;net, in our consolidated statements of operations for the year ended December 31, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants to acquire&#160;<ix:nonFraction unitRef="shares" contextRef="i37074bf992d247a491292198d0359ff0_I20140831" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc3Nzc_2455029d-8ff1-4b46-a039-79b3a25218d8">3,264,643</ix:nonFraction> shares of common stock with an exercise price of&#160;$<ix:nonFraction unitRef="usdPerShare" contextRef="i37074bf992d247a491292198d0359ff0_I20140831" decimals="2" name="us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc4NDM_5101d0d3-b051-4fe4-880d-1817bc2bfee1">125.08</ix:nonFraction> per share, subject to certain adjustments.&#160;The warrants have various expiration dates ranging from November 13, 2019 to April 22, 2020. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise price of the warrants, as measured under the terms of the warrant transactions. We received $<ix:nonFraction unitRef="usd" contextRef="i98d8d53ba8784c41bea403e9d3429ff2_D20140801-20140831" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzgyODM_b5a0d2bc-0aee-4b0f-ab91-14681891f42c">11.6</ix:nonFraction> million for these warrants and recorded this amount to additional paid-in capital. The common stock issuable upon exercise of the warrants will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC registering the issuance of the shares under the warrants.&#160;We continue to have the ability to avoid&#160;settling the warrants associated with the 2019 Notes in cash after May 22, 2018.&#160;Accordingly, the warrants continue to be classified in&#160;additional paid in capital.</span></div></ix:continuation><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">72</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i2b2f655f71fc4bb288beac13f0f5ac00" continuedAt="i6304d2c554bc400fb262a1db6b83b105"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In November 2018, we modified agreements with one of the bond hedge counterparties to cash settle a total of <ix:nonFraction unitRef="shares" contextRef="icf42ad343571467faece802b998bf88c_D20181101-20181130" decimals="INF" format="ixt:numdotdecimal" name="lgnd:WarrantsSettled" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3Mw_d26f496e-73b2-4d0f-a28b-627959b37d6e">525,000</ix:nonFraction>&#160;warrants. As the modifications required the warrants to be cash settled, the fair value of the warrants was reclassified from stockholders&#8217; equity to a derivative liability on the modification dates, resulting in a $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3Ng_27f1dd40-bfda-42e4-9c8c-7a9fc4b3bfb7">28.3</ix:nonFraction> million deduction to additional paid-in-capital during 2018. We settled these repurchases for total consideration of $<ix:nonFraction unitRef="usd" contextRef="icf42ad343571467faece802b998bf88c_D20181101-20181130" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:PaymentsForRepurchaseOfWarrants" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3OQ_826b3b70-b5a5-457b-9e39-140091090e3a">30.1</ix:nonFraction> million and recorded a&#160;$<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:DerivativeGainLossOnDerivativeNet" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4Mw_bd55f176-2d14-4c59-ab89-665d00f0cfa6">1.8</ix:nonFraction> million loss during 2018 on the change in the fair value of the derivative liabilities between their modification and settlement dates, which is included in other&#160;expense, net in the accompanying consolidated statement of operations. As a result, as of December 31, 2018,&#160;<ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ClassOfWarrantOrRightOutstanding" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4NQ_fb55d21a-218f-4b28-aa48-ae7bd14d888f">2,739,643</ix:nonFraction> warrants remain outstanding.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">0.75% Convertible Senior Notes due 2023</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2018, we issued $<ix:nonFraction unitRef="usd" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4OA_08c9e49e-626c-47e0-97fa-e0f98f984148">750</ix:nonFraction> million aggregate principal amount of 2023 Notes, bearing cash interest at a rate of&#160;<ix:nonFraction unitRef="number" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="INF" name="us-gaap:DebtInstrumentInterestRateStatedPercentage" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5MQ_3268bd4c-0666-447e-8a03-71c25cf60728">0.75</ix:nonFraction>%&#160;per year, payable semi-annually. The net proceeds from the offering,&#160;after deducting the initial purchasers' discount and offering expenses, were approximately $<ix:nonFraction unitRef="usd" contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromDebtNetOfIssuanceCosts" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5NA_4741c875-75d2-4978-8064-72ccc2dccd44">733.1</ix:nonFraction> million. The 2023 Notes will be&#160;convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on an initial&#160;conversion rate, subject to adjustment, of 4.0244 shares per $1,000 principal amount of the 2023 Notes which represents an initial&#160;conversion price of approximately $<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="us-gaap:DebtInstrumentConvertibleConversionPrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5Nw_5b860348-60e9-4990-89ef-a634bb6cc6e1">248.48</ix:nonFraction> per share.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Holders of the 2023 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding&#160;November 15, 2022, under any of the following circumstances:</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) during any fiscal quarter (and only during such fiscal quarter) commencing after September 30, 2018, if, for at least&#160;<ix:nonFraction unitRef="trading_day" contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdTradingDays" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg1MzQ4MA_24cf6a91-03d7-4949-a54f-169434b0049c">20</ix:nonFraction>&#160;trading&#160;days (whether or not consecutive) during the <ix:nonFraction unitRef="trading_day" contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwMA_4e09cacc-83ad-4334-b0dc-be5bf1065ae8">30</ix:nonFraction> consecutive trading day period ending on the last trading day of the immediately&#160;preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than&#160;<ix:nonFraction unitRef="number" contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwNA_cc9b9699-5e5d-4fde-9eff-c6c11540c35b">130</ix:nonFraction>% of the&#160;conversion price on such trading day;</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(2) during the&#160;<ix:nonFraction unitRef="trading_day" contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531" decimals="INF" format="ixt-sec:numwordsen" name="us-gaap:DebtInstrumentConvertibleThresholdTradingDays" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwNw_57970241-4480-4d9b-a1a0-a53e9aa0bc01">five</ix:nonFraction> business day period immediately following any&#160;<ix:nonFraction unitRef="trading_day" contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531" decimals="INF" name="us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxMA_6ed96257-12a8-430d-b267-987fc35d9633">10</ix:nonFraction> consecutive trading day period, in which the trading price per&#160;$1,000 principal amount of notes was less than&#160;<ix:nonFraction unitRef="number" contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531" decimals="INF" name="lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxMw_019df2e9-bdb5-4dff-9e10-96cbc8dc6bbc">98</ix:nonFraction>% of the product of the last reported sale price of our common stock on such&#160;trading day and the conversion rate on each such trading day; or</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At the May 22, 2018 issuance date of the 2023 Notes, we did not have the necessary number of authorized but unissued shares of&#160;our common stock available to settle the conversion option of the 2023 Notes in shares. Therefore, in accordance with guidance found in ASC&#160;815-15 &#8211; Embedded Derivatives, the conversion option of the Notes was deemed an embedded derivative requiring bifurcation from the&#160;2023 Notes (host contract) and separate accounting as a derivative liability. The fair value of the conversion option derivative liability at&#160;May 22, 2018 was $<ix:nonFraction unitRef="usd" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxNQ_f929c79b-9738-4ecc-9424-ae24cd2b3e78">144.0</ix:nonFraction> million, which was recorded as a reduction to the carrying value of the debt. This debt discount is amortized to&#160;interest expense over the term of the debt using the effective interest method. Up to the date in which we received shareholder approval on&#160;June 19, 2018 to increase the authorized number of shares of our common stock, the conversion option was accounted for as a liability with&#160;the resulting change in fair value of $<ix:nonFraction unitRef="usd" contextRef="i978ee51a08364e3eb7649d6141d3c780_D20180522-20180619" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDerivativeLiabilities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxOA_e1a609e3-7395-4a65-86d8-f976cf9fda13">13.5</ix:nonFraction> million during that period reflected in other expense, net, in our consolidated&#160;statements of operations for the year ended December 31, 2018. As of December 31, 2018, the debt discount remains and&#160;continues to be amortized to interest expense.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The notes will have a dilutive effect to the extent the average market price per share of common stock for a given reporting period exceeds&#160;the conversion price of $<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="us-gaap:DebtInstrumentConvertibleConversionPrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyMQ_08e718c9-df60-4d9d-b180-efe636de2a74">248.48</ix:nonFraction>. As of December 31, 2018, the &#8220;if-converted value&#8221; did not exceed the principal amount of the 2023&#160;Notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the issuance of the 2023 Notes, we incurred $<ix:nonFraction unitRef="usd" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DeferredFinanceCostsGross" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyNA_407683db-0487-4d9d-b3ea-bb3a3472f94e">16.9</ix:nonFraction> million of issuance costs, which primarily consisted of underwriting,&#160;legal and other professional fees. The portion of these costs allocated to the conversion option totaling&#160;$<ix:nonFraction unitRef="usd" contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyOA_a1e23b2f-09de-4066-9d98-164b1a63efc7">3.2</ix:nonFraction> million was recorded as interest&#160;expense for the twelve months ended&#160;December&#160;31, 2018. The portion of these costs allocated to the liability component totaling&#160;$<ix:nonFraction unitRef="usd" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentUnamortizedPremium" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzMQ_893384ba-b788-4922-b7b6-50ebd3ff7825">13.7</ix:nonFraction> million is amortized to interest expense using the effective interest method over the five year expected life of the 2023 Notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the&#160;principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Convertible Bond Hedge and Warrant Transactions</span></div></ix:continuation><div><span><br/></span></div><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">73</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i6304d2c554bc400fb262a1db6b83b105"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In conjunction with the 2023 Notes, in May 2018, we entered into convertible bond hedges and sold warrants covering <ix:nonFraction unitRef="shares" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1Mg_0edb4f45-03db-4f86-8d4b-064051dc0ead">3,018,327</ix:nonFraction> shares of&#160;our common stock to minimize the impact of potential dilution to our common stock and/or offset the cash payments we are required to&#160;make in excess of the principal amount upon conversion of the 2023 Notes. The convertible bond hedges have an exercise price of $<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="us-gaap:DebtInstrumentConvertibleConversionPrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1NQ_db0fb9a1-f6a2-4320-b25f-16a03b271ff9">248.48</ix:nonFraction>&#160;per share and are exercisable when and if the 2023 Notes are converted. We paid&#160;$<ix:nonFraction unitRef="usd" contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522" decimals="-5" format="ixt:numdotdecimal" name="lgnd:PaymentsforConvertibleBondHedges" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1OQ_88d8bab4-98fb-416d-b154-9196471e5b9d">140.3</ix:nonFraction> million for these convertible bond hedges. If upon&#160;conversion of the 2023 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties&#160;will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of&#160;common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible&#160;bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into&#160;by us and are not part of the terms of the 2023 Notes. Holders of the 2023 Notes and warrants will not have any rights with respect to the&#160;convertible bond hedges.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants covering&#160;<ix:nonFraction unitRef="shares" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2MQ_e53d95ba-329b-4592-8166-3dfcd78b67e3">3,018,327</ix:nonFraction> shares of common stock with an exercise price of $<ix:nonFraction unitRef="usdPerShare" contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522" decimals="2" name="us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2NQ_c6e76e46-2a66-45fc-96de-1dc55a41439c">315.38</ix:nonFraction> per share, subject to certain adjustments.&#160;We received $<ix:nonFraction unitRef="usd" contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2Nw_c671cf98-3ba7-44a1-a314-804c9a86e794">90.0</ix:nonFraction> million for these warrants. The warrants have various expiration dates ranging from August 15, 2023 to February 6,&#160;2024. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise&#160;price of the warrants, as measured under the terms of the warrant transactions. The common stock issuable upon exercise of the warrants&#160;will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC&#160;registering the issuance of the shares under the warrants.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">For the period from May 22, 2018, the issuance date of the bond hedge and warrant transactions, to June 19, 2018, the date shareholders&#160;approved an increase in our authorized shares of common stock, the bond hedges and warrants required cash settlement and were accounted&#160;for as a derivative asset and liability, respectively, with the resulting increase in fair value of $<ix:nonFraction unitRef="usd" contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDerivativeAssets" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTY5ODY_a8a06594-efce-43ac-98b0-02352169397f">19.2</ix:nonFraction> million&#160;and $<ix:nonFraction unitRef="usd" contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncreaseDecreaseInDerivativeLiabilities" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3MA_3e2e7552-6d26-42ee-9c36-5516e976a4f0">7.5</ix:nonFraction> million&#160;reflected in other expense, net, in our consolidated statements of operations for twelve months ended&#160;December&#160;31, 2018.</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfDebtTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzk4OTU2MDQ2ODM0Mzc_300dcb45-02f8-4093-a18c-8aac9dfcf0cc" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes information about the equity and liability components of the 2019 Notes and 2023 Notes (in thousands).</span></div><div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:57.970674%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:16.768328%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:2.292669%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:16.768328%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2019 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i788db1d002a24118902ba114a1c848a8_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzEtMS0xLTEtMjQyNA_38fc57ea-22f5-4ea5-8bcb-1c2eb3abad2b">27,326</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i8517c8b0243e45e096978d0ca26893b0_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzEtMy0xLTEtMjM5OA_b6a02e1f-820e-48d9-9911-2c497bd47d15">245,000</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i788db1d002a24118902ba114a1c848a8_I20181231" decimals="-3" name="us-gaap:DebtInstrumentUnamortizedDiscount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzItMS0xLTEtMA_a43fff74-1a8d-4742-b35c-dfd509e4c80e">893</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i8517c8b0243e45e096978d0ca26893b0_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentUnamortizedDiscount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzItMy0xLTEtMA_5b637ee6-6e9c-4df3-b39e-7512d8a60269">20,471</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total current portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NotesPayableCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzQtMS0xLTEtMA_4dfba632-8a00-4700-97b6-0fafee2958a6">26,433</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NotesPayableCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzQtMy0xLTEtMA_d11d6c53-6512-4f8c-a41b-213b68dd32b0">224,529</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2023 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentFaceAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzUtMS0xLTEtMjQ2Mw_dd2c5a84-2c66-4dc5-8e8c-b4b3baafc34d">750,000</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DebtInstrumentFaceAmount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzUtMy0xLTEtODcwMA_14294591-f40d-4d1f-bb15-b27327b438ee">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentUnamortizedDiscount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzYtMS0xLTEtMjQ2Ng_999d1bb7-c616-48b3-a1ae-fdcb56c07104">140,136</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DebtInstrumentUnamortizedDiscount" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzYtMy0xLTEtODY5OA_4ba8e8de-abd1-49cc-b299-4256bca4902a">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total long-term portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:LongTermNotesPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzctMS0xLTEtODY5Mg_0af6a41e-7b7a-463c-9c95-8619f68881c8">609,864</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:LongTermNotesPayable" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzctMy0xLTEtODY5Ng_6197a1ef-28cd-4fb2-bb7d-ba76ac96cc8e">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Carrying value of equity component of 2023 Notes</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzgtMS0xLTEtMjUxMA_69dcb941-5466-4972-b88b-c00cb7a900e0">127,997</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzgtMy0xLTEtODY5NA_d1a3ca2a-18af-4be6-a7cc-5c515825801c">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of convertible senior notes outstanding (Level 2)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ConvertibleDebtFairValueDisclosures" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzktMS0xLTEtMjUxOA_f3caa687-4217-4a3a-95f6-0d320ef8a900">713,533</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ConvertibleDebtFairValueDisclosures" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzktMy0xLTEtMjQ4OQ_4f796d07-9939-47ae-8a7f-6bfdd6018ed6">446,360</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div></ix:nonNumeric><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, there were no events of default or violation of any covenants under our financing obligations.</span></div></ix:continuation><div id="i_0_457"></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">7. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:SupplementalBalanceSheetDisclosuresTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzI1Njg_e7debccb-0132-4f62-beb5-38437ed591eb" continuedAt="iae3a4a66377f483fa07c4effc7d1f925" escape="true">Balance Sheet Account Details</ix:nonNumeric></span></div><div style="text-indent:24pt;margin-top:5pt;"><span><br/></span></div><div style="margin-bottom:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"><ix:continuation id="iae3a4a66377f483fa07c4effc7d1f925" continuedAt="i20fa1e0e56484a78900445684979ded0">Short-term Investments</ix:continuation></span></div><div style="margin-top:5pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">74</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i20fa1e0e56484a78900445684979ded0" continuedAt="i59556924052148759445f11d61fd6cec"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM1OTk_8509e45b-2a32-4f85-829b-46451978221e" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the various investment categories at December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:41.088235%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:11.676471%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.676471%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.676471%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.676471%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cost</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">gains</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">losses</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Estimated</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">fair value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if09401cad196425ab690698455cc8c3d_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtMS0xLTEtMA_d4e75c83-3ccc-4132-a731-2df242daccf6">311,066</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if09401cad196425ab690698455cc8c3d_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtMy0xLTEtMA_a82e30d2-57bd-497b-bd01-faa25d86c80c">26</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if09401cad196425ab690698455cc8c3d_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtNS0xLTEtMA_9cded3f8-6e97-45a0-8222-f88ea62e1e99">29</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if09401cad196425ab690698455cc8c3d_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtNy0xLTEtMA_b87c2269-43a7-47d5-811a-9ce0e0d773c6">311,063</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i68ecb47464af47feb893f53340e5806b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtMS0xLTEtMA_91f4f763-185d-4162-9327-c3473eb3d60e">53,223</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i68ecb47464af47feb893f53340e5806b_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtMy0xLTEtMA_3b182588-5829-4899-93f9-5b0ae734e1c4">1</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i68ecb47464af47feb893f53340e5806b_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtNS0xLTEtMA_06557a01-139a-4441-93ea-efb0e69f3a32">45</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i68ecb47464af47feb893f53340e5806b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtNy0xLTEtMA_4495ea00-34c5-46f4-b08f-fd8be77c8291">53,179</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtMS0xLTEtMA_e8b0b18f-8763-452d-aa0d-b751f5b33c3c">135</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtMy0xLTEtMA_454df91b-08f0-47fb-92c9-feee5ab5beb1">1,191</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtNS0xLTEtMA_5699e679-ba9a-4d6e-b473-f35b57752807">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtNy0xLTEtMA_0a22953d-e907-4f51-a009-2a869daccb6a">1,326</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtMS0xLTEtMA_35cfc6d7-7852-488c-966d-f180eb920fd5">225,731</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtMy0xLTEtMA_078987a9-10ac-4481-854a-cfbea720abbc">8</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtNS0xLTEtMA_c0cca924-e593-4dbe-904c-7bcff9f94372">76</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtNy0xLTEtMA_0548dc95-b494-4656-8c3f-222eda65ac3f">225,663</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i40f8bac802b34bae87d73215caf27338_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtMS0xLTEtMA_6963df10-8104-4ec4-99f6-96429a46fbb7">7,982</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i40f8bac802b34bae87d73215caf27338_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtMy0xLTEtMA_c3f3acf3-4149-42d9-abc5-e5c688c52373">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i40f8bac802b34bae87d73215caf27338_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtNS0xLTEtMA_8148f34a-ec32-4431-8902-4fc4d20fd202">9</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i40f8bac802b34bae87d73215caf27338_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtNy0xLTEtMA_d555c135-d316-4fb4-95bd-a53c883a1537">7,973</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktMS0xLTEtMA_b1a64035-faa5-4e86-8aa6-248957ca6dec">2,017</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktMy0xLTEtMA_08c24427-4060-46fd-87b4-4a849509a3c1">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktNS0xLTEtMA_e6c701be-4590-4c2f-8f8c-7c17eaa9641b">4</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktNy0xLTEtMA_be1d7e08-610b-4a4d-8f6b-e21d8e17717f">2,013</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTEtMS0xLTA_2bda60f8-400c-4350-863d-ca11229b0451">600,154</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTMtMS0xLTA_de2e03dc-cfff-48c9-adbc-8dcee3d26f2a">1,226</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTUtMS0xLTA_5345930a-b411-4887-a0a6-fa34f0631fba">163</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTctMS0xLTA_43a1b85b-ca5b-4900-9de3-cd79fff42555">601,217</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i843b12a2426b42a0a044c4840af01886_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTEtMS0xLTA_aec024db-fea7-4307-bee2-7411c4515179">80,095</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i843b12a2426b42a0a044c4840af01886_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTMtMS0xLTA_63f30123-6553-44bf-a412-18b58fdbfe52">6</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i843b12a2426b42a0a044c4840af01886_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTUtMS0xLTA_58495694-f71d-4742-90ea-7ad965a62d8a">42</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i843b12a2426b42a0a044c4840af01886_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTctMS0xLTA_c8398a88-e9f3-47ed-a0a4-e06a1c714a45">80,059</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTEtMS0xLTA_dbf63082-86f9-42ed-acd9-807bf1b682dc">55,335</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTMtMS0xLTA_b89c82a5-6ccb-48ca-8f3c-fb1e1400183b">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTUtMS0xLTA_6252e79b-9377-47ba-9ef8-b342ae16dc5b">96</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTctMS0xLTA_ee17429f-8a16-48fc-ac19-a1eb596b2ea1">55,239</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTEtMS0xLTA_9e2b8470-6945-4db8-a18a-fbad43cd151f">207</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTMtMS0xLTA_379bfc2c-9734-490b-baf8-756d37734ef7">1689</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTUtMS0xLTA_2a3d0ba4-02b6-4633-abf9-c552a11b8a2c">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTctMS0xLTA_972ceda9-2e9e-4baf-92d0-a7f64710da44">1,896</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i314bde6d607f4e658a119ca41affb344_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTEtMS0xLTA_ead9502e-7f21-46c6-9846-1dc0e6e790ff">27,933</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i314bde6d607f4e658a119ca41affb344_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTMtMS0xLTA_9a849405-0b39-4cbc-bef8-8a899badda55">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i314bde6d607f4e658a119ca41affb344_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTUtMS0xLTA_48da69ce-44f2-451c-815e-521a15986459">20</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i314bde6d607f4e658a119ca41affb344_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTctMS0xLTA_12c23c10-9d54-47cf-95ec-081984ab4ddf">27,913</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Agency bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i08498294a183499a9bf71fb60b17b954_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTEtMS0xLTA_6b4f48fd-6caf-4931-82ea-cc4c4c1c305f">4,991</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i08498294a183499a9bf71fb60b17b954_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTMtMS0xLTA_bdc44bf2-a958-4558-855c-7ec132e0a956">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i08498294a183499a9bf71fb60b17b954_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTUtMS0xLTA_e0297a65-e3c5-4988-afe0-8c6f1f576f5e">1</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i08498294a183499a9bf71fb60b17b954_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTctMS0xLTA_9324c03d-a6e7-477c-a3ae-ec794c499c30">4,990</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTEtMS0xLTA_0e7e0f4d-024a-43d8-b2cc-d88113eadf72">8,939</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTMtMS0xLTA_a27722ef-1d05-484d-9604-9f34b4ce7193">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTUtMS0xLTA_73bd347d-54b5-40c2-a3e3-3a062317b757">10</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTctMS0xLTA_70eae45a-11ea-49bb-a712-2eca5ceb3d76">8,929</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTEtMS0xLTA_b3e8ea7c-5250-4b1a-bec9-a62aa34209b0">2,028</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTMtMS0xLTA_7f94710c-86ab-44ae-9d07-c43b51066981">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTUtMS0xLTA_d21eea63-dc89-42fc-b532-00b55391c333">13</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTctMS0xLTA_b14cffa1-22f8-4844-af29-4d11e4f4434e">2,015</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTEtMS0xLTA_e90b725d-893a-46cf-af5f-1af2b5483777">179,528</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTMtMS0xLTA_38380b06-df7e-4d81-ad29-4f272e04a038">1,695</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231" decimals="-3" name="us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTUtMS0xLTA_8f77e9e3-50c5-4e0d-b4dd-eb2ff5dc41a6">182</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AvailableForSaleSecuritiesDebtSecurities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTctMS0xLTA_b752c528-8386-4ddb-a77e-6830e710fe11">181,041</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;margin-top:5pt;"><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfOtherCurrentAssetsTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDA_df2297b3-d2ef-4de4-8d34-bb95053fc5ed" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Other current assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:72.008811%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RestrictedCashCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzMtMS0xLTEtMA_0967caec-0b68-4739-b90d-ff1c5888cc81">2,616</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:RestrictedCashCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzMtMy0xLTEtMA_d1ec1b49-847e-43ac-bb4d-1c6ffd649038">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking warrants</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:WarrantsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMS0xLTEtODMyNQ_1df87807-7032-4bb3-82e5-2032aa3d2997">9,257</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="lgnd:WarrantsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMy0xLTEtODMyMQ_7833371e-b0ca-4b12-9bab-099b1acb1ceb">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OtherAssetsCurrentOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMS0xLTEtMA_0f622cc3-6937-42cb-ab06-949226a99131">8,545</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:OtherAssetsCurrentOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMy0xLTEtMA_73e31a3d-6a61-49f3-a149-3c173c797e0c">1,514</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzUtMS0xLTEtMA_b171ca13-55bb-4f17-b081-0fda91d40748">20,418</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAssetsCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzUtMy0xLTEtMA_f8c75495-222f-474f-8ca4-32889eae2787">1,514</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:PropertyPlantAndEquipmentTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDE_bb7af50b-c6d2-4bdf-b782-2c323fe12c5d" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and equipment is stated at cost and consists of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:72.008811%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lab and office equipment</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i16fdeb617d3e4ad69654c02d20dca967_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzItMS0xLTEtMA_b1e942f7-5d0b-452c-89c8-7ef78d1c5b9e">4,183</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iac24af30dd5947d69f092c0143c72cd5_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzItMy0xLTEtMA_3b0a044d-2912-4c02-9c3b-6afe2613de02">3,460</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Leasehold improvements</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4e5237e21cd94cbe8fb403d08bacef1f_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzMtMS0xLTEtMA_3b52bd83-89f1-45dd-bbdb-95f06cbf319d">2,418</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i5d2d421f80254076b1c05f7d56f73e55_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzMtMy0xLTEtMA_70227321-3d56-441d-9216-77b7efabb190">1,917</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Computer equipment and software</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic146a47155124f8587de68b7f7bf2916_I20181231" decimals="-3" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzQtMS0xLTEtMA_62d9f88d-903b-4c85-a53c-98947c6efad3">936</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2f59fb3a08394604ad40621952d209ac_I20171231" decimals="-3" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzQtMy0xLTEtMA_8aaa2ec4-6f9d-4519-b299-c45c8587f325">697</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzUtMS0xLTEtMA_8949223b-acbf-487d-b109-33049e5abdfa">7,537</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzUtMy0xLTEtMA_205f67cb-1a07-48c8-9eac-32ae1630018c">6,074</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less accumulated depreciation and amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzYtMS0xLTEtMA_85df652c-ddb0-402e-8bb9-0192a5c1511b">2,165</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzYtMy0xLTEtMA_9290a1ff-2fe2-4985-8492-cf06a2baa2c8">1,862</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzctMS0xLTEtMA_e29c6eef-fc19-48ea-ac33-6245515452c9">5,372</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:PropertyPlantAndEquipmentNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzctMy0xLTEtMA_d8c43a48-c36c-45f3-a670-7d4393927db3">4,212</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter. Depreciation expense of $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:Depreciation" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY1MA_a1081043-7c8f-4d53-b198-09c6daf8b492">0.9</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:Depreciation" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY1NA_c0980122-ee6f-441f-bb6d-15a69e9ef586">0.4</ix:nonFraction> million, and $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:Depreciation" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY2Mg_9fd82494-a3bd-481b-87fe-9b274e174f11">0.2</ix:nonFraction> million was recognized for the years ended December&#160;31, 2018, 2017, and 2016, respectively, and is included in operating expenses.</span></div></ix:continuation><div style="text-indent:24pt;margin-top:5pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">75</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i59556924052148759445f11d61fd6cec" continuedAt="i8a0eff76d51b45c1ad9c6751a3eccca1"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDI_6dde6194-39ec-4ba8-952e-d7c997fc38d4" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill and identifiable intangible assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:72.008811%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indefinite lived intangible assets</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     IPR&amp;D</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if00b0dbd22ec4957944d58677bc41590_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IndefiniteLivedIntangibleAssetsExcludingGoodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzMtMy0xLTEtMA_134e3a11-bce4-4296-bdf8-d9be18fae38e">7,923</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzQtMS0xLTEtMA_918c94de-9039-43f9-a2dd-4753eea5a886">86,646</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:Goodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzQtMy0xLTEtMA_fbfa2c74-dfad-4389-a9b8-a1da564ea6fa">85,959</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Definite lived intangible assets</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Complete technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzYtMS0xLTEtMA_64177eae-d980-4649-8580-a3aa4914ec5b">235,413</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i17da7efba5044964a299fa1b88c45d89_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzYtMy0xLTEtMA_ce97c0d7-bf24-44f4-9dea-0a48609c3f99">222,900</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzctMS0xLTEtMA_bcaaf519-4809-4ea9-a0ad-21bc3bb742d2">35,070</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i17da7efba5044964a299fa1b88c45d89_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzctMy0xLTEtMA_2ddee11f-336a-4469-85dc-6514ef3a2717">23,301</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Trade name</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i25a1b9803d204d8399b4072bc7f1feba_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzgtMS0xLTEtMA_2d0d495c-0bf8-4a09-bca5-7d93a49f97bd">2,642</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i098eec66c5b3403da1e52d65ba40fb09_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzgtMy0xLTEtMA_bd3f4df9-e855-4cad-8773-c08c5f539812">2,642</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i25a1b9803d204d8399b4072bc7f1feba_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzktMS0xLTEtMA_31dc1cba-78a4-4b02-b4c8-1ad94f0c4711">1,048</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i098eec66c5b3403da1e52d65ba40fb09_I20171231" decimals="-3" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzktMy0xLTEtMA_3f1e6545-9cb8-42e7-8f1f-a73e5c9ce333">916</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Customer relationships</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEwLTEtMS0xLTA_b940a4db-816f-4e47-92ba-de610285cce1">29,600</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ida0878f2976a419ab990ac37bb697cf4_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEwLTMtMS0xLTA_4213e99c-bbbe-46ad-b765-24b7f8619d85">29,600</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzExLTEtMS0xLTA_68e7973e-8d02-48e3-b89c-9ec6117d896e">11,744</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ida0878f2976a419ab990ac37bb697cf4_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzExLTMtMS0xLTA_ef6b95da-6bcf-40bb-bea9-c30dee61aa15">10,264</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total goodwill and other identifiable intangible assets, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IntangibleAssetsNetIncludingGoodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEyLTEtMS0xLTA_220bc792-b815-43b9-a20c-0e0c803ffe21">306,439</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IntangibleAssetsNetIncludingGoodwill" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEyLTMtMS0xLTA_f53d13fe-c29c-45c9-99b3-c68b4f5a5d2d">314,543</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Amortization of finite lived intangible assets is computed using the straight-line method over the estimated useful life of the asset&#160;of <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:FiniteLivedIntangibleAssetUsefulLife" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzU0OTc1NTgxNzc0NA_92d88571-6fb1-40a3-8993-a97348071153">20</ix:nonNumeric> years. Amortization expense of $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfIntangibleAssets" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwMzI_681dfa64-f652-49a3-ae2d-08ad13b3d19f">15.8</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfIntangibleAssets" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwMzY_a51a4417-11db-4cfc-bf50-b59a47cd9d42">11.3</ix:nonFraction> million, and $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:AmortizationOfIntangibleAssets" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwNDQ_ab306f40-1311-4164-88e8-1e44366b3d09">10.6</ix:nonFraction> million was recognized for the years ended December&#160;31, 2018 and&#160;2017, and 2016, respectively. Estimated amortization expense for the years ending December&#160;31, 2018 through 2023 is $<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzExODk_64cc8508-fd98-44cb-93e1-4015ebf6b9dd">13.6</ix:nonFraction> million per year. For each of the years ended December&#160;31, 2018, 2017, and 2016, there was&#160;<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt-sec:numwordsen" name="us-gaap:ImpairmentOfIntangibleAssetsFinitelived" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzU0OTc1NTgxNzY2Mw_286b381d-656a-4834-8340-624fc7312873">no</ix:nonFraction>&#160;impairment of intangible assets with finite lives.</span></div><div style="text-indent:24pt;"><span><br/></span></div><div style="text-indent:36pt;"><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDM_c448bdcc-2d27-4001-8412-b9921a56450f" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accrued liabilities consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:72.008811%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Compensation</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:EmployeeRelatedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzItMS0xLTEtMA_00dba084-97fa-4983-9826-4b18bbe29fc9">4,045</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:EmployeeRelatedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzItMy0xLTEtMA_7365ecdf-237f-4438-8d55-fbe232488ea2">4,085</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Legal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:AccruedProfessionalFeesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzMtMS0xLTEtMA_20297378-11aa-4e2a-93b1-db299158e919">942</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:AccruedProfessionalFeesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzMtMy0xLTEtMA_5c27cc13-1be5-4fb0-b3a8-c332c374c0e4">430</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amounts owed to former licensees</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:AccruedSalesCommissionCurrentAndNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzQtMS0xLTEtMA_199e3b76-f0fd-489c-8c38-79d45e317e07">428</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:AccruedSalesCommissionCurrentAndNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzQtMy0xLTEtMA_ac4a4732-e2fd-4be4-bba4-11d3fb8ea84d">396</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties owed to third parties</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccruedRoyaltiesCurrentAndNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzUtMS0xLTEtMA_84c009eb-bb02-4243-b4a7-b9b05ec31073">1,025</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:AccruedRoyaltiesCurrentAndNoncurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzUtMy0xLTEtMA_e3116f74-8cbd-46d7-9af6-b510290e43e2">954</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments due to broker for share repurchases</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AccruedStockRepurchases" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMS0xLTEtMTIzOTU_b9d32676-bbc8-4eeb-bb64-b97d1c37d101">4,613</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="lgnd:AccruedStockRepurchases" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMy0xLTEtMTI0MDQ_01840227-367d-40bd-b710-202f77e5e76b">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Return reserve</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:AccruedSalesReturns" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMS0xLTEtMTIzOTg_521dfc95-21f0-44db-9caf-44ffb2bc743a">3,590</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="lgnd:AccruedSalesReturns" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMy0xLTEtMTI0MDc_3cb4a28d-aa71-4586-b895-20f470c00804">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RestructuringReserveCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzktMS0xLTEtMTI0MDE_0ab61afa-e8f4-424a-a35b-9810b4b47c8c">1,093</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:RestructuringReserveCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzktMy0xLTEtMTI0MTA_e35cd5c2-aa9e-4962-adab-702d1a3b13fb">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMS0xLTEtMA_bb45ba31-c24c-4ef4-9910-217ca9f80a60">3,464</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OtherAccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMy0xLTEtMA_0f21cd11-a3a2-43c8-947f-d7b0fe657d2e">1,512</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMS0xLTEtMA_5bb7ff54-1aa1-496d-964d-fed783e96b28">19,200</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AccruedLiabilitiesCurrent" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMy0xLTEtMA_87899b09-bfed-46ac-9f45-3d2fda5a485b">7,377</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Contingent liabilities:</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of CyDex in January 2011, we issued a series of CVRs and also assumed certain contingent liabilities. We may be required to make additional payments upon achievement of certain clinical and regulatory milestones to the CyDex shareholders and former license holders. We paid CyDex&#160;shareholders, through 2016, <ix:nonFraction unitRef="number" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" name="lgnd:RevenueRoyaltytoAcquireeShareholdersPercent" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE3Mjk_6758946c-1302-469a-b701-23987b5f07f9">20</ix:nonFraction>% of all&#160;CyDex-related revenue, but only to the extent that, and beginning only when,&#160;CyDex-related revenue for the year exceeds $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE4NTk_a13d6ffc-562c-4b3a-ad57-6ad7f48fe136">15.0</ix:nonFraction> million; plus an additional <ix:nonFraction unitRef="number" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" name="lgnd:AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" scale="-2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE4ODI_9559f44b-909a-4d8a-a63b-47553ab8dba6">10</ix:nonFraction>% of all CyDex-related revenue recognized during such year, but only to the extent, and beginning only when aggregate CyDex-related revenue for such year exceeds $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="lgnd:ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzIwNDU_0f66db7a-540e-4064-b035-fbd9f4323df1">35.0</ix:nonFraction> million.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of Metabasis in January 2010, we entered into four CVR agreements with Metabasis shareholders. The CVRs entitle the holders to cash payments as frequently as every six months as proceeds are received by us upon the sale or licensing of any of the Metabasis drug development programs and upon the achievement of specified milestones.</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div></ix:continuation><div style="margin-top:5pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">76</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i8a0eff76d51b45c1ad9c6751a3eccca1"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:ScheduleofContingentLiabilitiesTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzgyNDYzMzcyMTQxMDA_47feb5ee-ac7f-471b-b2d5-22af4629fdd8" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes contingent liabilities&#160;as of December 2018 and 2017 (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.736842%;"><tr><td style="width:1.0%;"></td><td style="width:9.728395%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.265432%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.876543%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.728395%;"></td><td style="width:1.0%;"></td><td colspan="3" style="display:none;"></td><td style="width:1.0%;"></td><td style="width:9.419753%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.419753%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.413580%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.419753%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.728395%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Additions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cydex</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ic732878aa6064bd6999a01fcb26ffafb_I20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMS0xLTEtMA_39da92aa-6ce8-4c51-a7b6-ba657fa79fad">6,600</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMi0xLTEtMA_fb9f0be1-b89d-4846-8637-177b8e49255a">5,000</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMy0xLTEtMA_93a2711f-b11c-4cef-ad99-2db86b9d6387">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNS0xLTEtOTAwMg_49cfc8ff-d24c-4014-8f5f-ae250603592b">&#8212;</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="idfb5b3bf1daa4956a0677ba6e2b17a09_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNS0xLTEtMA_a961ee97-6463-4498-8c52-e7555469c710">1,600</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231" decimals="-3" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNi0xLTEtMA_8a6fc826-4eef-460b-8b6f-9c6d31b81ac5">25</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNy0xLTEtMA_5c3a8ed8-35a2-4e02-b4c9-236b7630fa74">1,050</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6555f01d1e2a414bb4602de9db064582_I20181231" decimals="-3" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtOS0xLTEtMA_8200f913-fd99-4e25-bab9-837b41ae952d">525</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i04a307d0dd25404c9e1b6973b4fcfcfc_I20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMS0xLTEtMA_7901e98d-8438-4e48-81fb-4d31494e5717">1,500</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMi0xLTEtMA_c20eec57-7f21-4629-aaf2-c7b92ab24c9f">&#8212;</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMy0xLTEtMA_7e14a5e6-d758-491a-927f-d5a974549c7b">2,500</ix:nonFraction>&#160;</span></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNS0xLTEtOTAwNA_83ef62e0-2646-466a-b7d7-63d7270661f5">&#8212;</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i962f4a871df84f71a3762aabb69d87d4_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNS0xLTEtMA_1d76ebee-e553-4a0e-9e4b-e4575964d323">4,000</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNi0xLTEtMA_08cdfddd-3274-4bbf-9bc8-6f2c960b208c">3,900</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNy0xLTEtMA_976fcf78-e6fa-4adb-a49a-9b61cf62cb52">5,400</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i5a6f5527bcd749ebb994ee78a83dec16_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItOS0xLTEtMA_8e664e50-e8dc-4987-9eae-4e75fb995a31">5,500</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i3ddcb2326de24ff388c9dabc96f2f7ab_I20161231" decimals="-3" format="ixt:zerodash" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMS0xLTEtMA_1c916c1b-d296-423f-8587-c5dde4240c10">&#8212;</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMi0xLTEtMA_b11b7218-f364-4878-9e4d-73fd47679a66">&#8212;</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMy0xLTEtMA_3c2e5243-b693-4a57-817d-441578736cf6">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNS0xLTEtOTAwNg_a5f07c89-82f3-44b5-b871-3ad3e1b6480f">8,400</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i3dc153fa027840bfaf8d39d7777fca8a_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNS0xLTEtMA_f1c707aa-bd5a-46d8-8c15-94beb67b22c6">8,400</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNi0xLTEtMA_04f14177-7a40-4f8d-8672-ab78ebe342f7">1,000</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231" decimals="-3" sign="-" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNy0xLTEtMA_de671289-3618-47f8-aeff-465cbc6b5555">924</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtOS0xLTEtMA_6b0f7944-d348-478e-839e-bd14bf5f5871">6,476</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMS0xLTEtMA_5b87a64e-a9a4-49f6-8384-bdada3ff00fe">8,100</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMi0xLTEtMA_14fdec41-bf43-4116-b164-edcce2cddbc6">5,000</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMy0xLTEtMA_5c573fae-eb0e-4287-a56b-9ed12a7df405">2,500</ix:nonFraction>&#160;</span></td><td colspan="3" style="display:none;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNS0xLTEtOTAwOA_0099295f-7dd4-40d6-8de8-999ca68215cd">8,400</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNS0xLTEtMA_aa2dc567-297c-4685-841b-94b051b92907">14,000</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:PaymentsToContingentValueRightHolders" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNi0xLTEtMA_4ecbc9a1-d929-42ae-b9a5-44c2732f7d8c">4,925</ix:nonFraction>)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNy0xLTEtMA_63bc3b80-f2a5-47d9-9e9c-a942fef0993e">3,426</ix:nonFraction>&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtOS0xLTEtMA_9b255e66-b0f3-4e9c-a645-48c353123f46">12,501</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric></ix:continuation><div style="text-align:center;"><span><br/></span></div><div id="i_0_482"></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;"> 8. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:StockholdersEquityNoteDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI4Njg_d62cb370-baae-46f1-9f71-82235d2d666f" continuedAt="i0180f5eb6792445c93a1081453ead4b0" escape="true">Stockholders&#8217; Equity</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i0180f5eb6792445c93a1081453ead4b0" continuedAt="ib965b149918642cba40a74aa813f98f2"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share-based Compensation Expense</span></div><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDQ_3a9e00bd-146e-416a-beb7-9e7b52c12ab4" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes share-based compensation expense (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:63.102639%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.143695%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.533138%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.143695%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.533138%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.143695%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation expense as a component of:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development expenses</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="idaab1982bed149178b9a7a902d4ec9b1_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtMS0xLTEtMA_93e1dbe6-9717-46d5-9aba-205600419885">8,352</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i5525fb7204b24ebb9a94c522e3490ed3_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtMy0xLTEtMA_f1d93bc7-046e-4d52-8a1c-5eee8b8770fd">14,235</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i660b0db80fb243a9aa215587f3e20997_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtNS0xLTEtMA_77e8b3d5-97cd-44fa-a60b-6bc79ac1ff7a">8,836</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i6387378ce4f1495fbf9934bbc7f8004b_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtMS0xLTEtMA_5f71c08f-b3de-4cce-8569-8e02f9d48c0e">12,494</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i008883d729b243ce80c4af9827bf6117_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtMy0xLTEtMA_6fbb4243-7912-404e-a086-b7bf83e3c8f0">10,680</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9e6c1c39ab414f958545d7f4f2e968ea_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtNS0xLTEtMA_4a2eccbc-238a-4cbe-ba0c-c45503e8bb2c">10,057</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtMS0xLTEtMA_38eef9b0-fa1b-4d7b-bde7-8f59d3b89200">20,846</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtMy0xLTEtMA_51fba997-2ddc-45d2-bf3d-b88891b2a1bf">24,915</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtNS0xLTEtMA_179dc4e3-2d79-4f51-890b-9eb3f56dcd1c">18,893</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Stock Plans</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2012 and May 2016, our 2002 Stock Incentive Plan was amended to increase the number of shares available for issuance by <ix:nonFraction unitRef="shares" contextRef="i8122f73ad096454d8683e1fb385d450f_D20120530-20120531" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM2Mw_bef35512-3c6f-486c-8570-534edd7a558f">1.8</ix:nonFraction> million&#160;&#160;and <ix:nonFraction unitRef="shares" contextRef="i10821c8abf4c413496e40313cc3d82c6_D20160501-20160531" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM3MQ_6dc4866c-d74c-4b07-bdee-6b0275a15586">0.9</ix:nonFraction> million shares, respectively.  As of December&#160;31, 2018, there were <ix:nonFraction unitRef="shares" contextRef="iefc813acbb6448ec99d57a49fe36770e_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzQxOA_c2dfe8b4-e03d-499e-9de7-954507a48953">0.6</ix:nonFraction> million shares available for future option grants or direct issuance under the Amended 2002 Plan.</span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDM_904f58e9-0e78-4ba5-935a-f2898483f70a" escape="true"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a summary of our stock option plan activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"></td><td style="width:48.220913%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.076583%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.076583%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.076583%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.340206%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Exercise</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Remaining</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Contractual</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Term in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Aggregate</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Intrinsic</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">(In&#160; thousands)</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtMS0xLTEtMA_a9aa0dec-641b-4d12-893e-a8bc698a3f19">1,876,332</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtMy0xLTEtMA_7517e4bd-6bbb-452f-8a77-fc454fde1203">53.17</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtNS0xLTEtMA_dcb4e79b-85c5-4578-9d18-99dcfeb3ba41">5.77</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtNy0xLTEtMA_59072fac-a6fe-495a-83fc-341724d7272e">157,340</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzItMS0xLTEtMA_27c17eb1-73ee-4c1c-94a9-695d56634a02">228,362</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzItMy0xLTEtMA_b1f26c2d-2ce2-45d8-b491-35602a9c3eab">162.00</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercised</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzMtMS0xLTEtMA_4644c3b8-cb07-47e9-8eef-53c5effbef75">358,162</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzMtMy0xLTEtMA_ed9cccf7-c1fd-457b-a1ff-f7c58ba22cae">55.24</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzQtMS0xLTEtMA_98efe3f7-086c-4fa5-9fca-13bef89c686a">10,228</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzQtMy0xLTEtMA_c66ed5c1-c583-4bb2-abc5-70f24d1dc4e8">114.53</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December 31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtMS0xLTEtMA_6da5f6cf-4051-4ec5-a2fd-51949391477f">1,736,304</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtMy0xLTEtMA_369489dc-e4ef-4569-8386-a93d97eaace1">66.71</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtNS0xLTEtMA_856b6217-f2d6-4f20-820e-f50ec721bcfe">5.47</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtNy0xLTEtMA_85a3dcd3-f9d9-4ac9-a1fc-ae1b2ff552c4">125,858</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercisable at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtMS0xLTEtMA_8da2e11d-9e3d-41fc-ace9-ac43c85fe2fb">1,313,374</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtMy0xLTEtMA_2cc0476f-8a57-43a1-aecf-a971679b8059">47.03</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtNS0xLTEtMA_ed959b33-8175-4731-af61-6e649701e8d2">4.56</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtNy0xLTEtMA_1660af8b-b475-4278-bb8e-dadd6d6166fd">117,314</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Options vested and expected to vest as of December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctMS0xLTEtMA_add330cd-e1af-44cf-ba6b-8b9d2d8a6d2f">1,734,304</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctMy0xLTEtMA_45fb88e3-dc67-4a7b-ab91-f3537c7e0758">66.71</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctNS0xLTEtMA_6cfb83b9-bbab-437b-b449-651bbfb3f036">5.47</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctNy0xLTEtMA_ab22621b-c956-4c55-8e01-10e94e4744f8">125,858</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The weighted-average grant-date fair value of all stock options granted during 2018, 2017 and 2016 was $<ix:nonFraction unitRef="usdPerShare" contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcwOQ_69a92ff4-534a-4327-94a1-64edad59de0d">66.71</ix:nonFraction>, $<ix:nonFraction unitRef="usdPerShare" contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcxMw_825775ce-f4cd-4a9f-8793-0209caa02bf4">53.17</ix:nonFraction> and $<ix:nonFraction unitRef="usdPerShare" contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcyMA_3e2a1b70-c54d-4471-a098-1f5615663c08">46.53</ix:nonFraction> per share, respectively. The total intrinsic value of all options exercised during 2018, 2017 and 2016 was approximately $<ix:nonFraction unitRef="usd" contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzgzOA_07d56cfd-21ca-4024-b41b-86c2879e9ec4">51.9</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzg0Mg_1bf97062-6222-4f43-a65e-9ee1927b14d8">13.3</ix:nonFraction> million and&#160;$<ix:nonFraction unitRef="usd" contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAwOTI_1f23faff-97aa-41cc-a424-116a60b302e4">12.0</ix:nonFraction> million, respectively. </span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Cash received from options exercised, net of fees paid, in 2018, 2017 and 2016 was $<ix:nonFraction unitRef="usd" contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk0Ng_9c85b438-0785-4f9e-8718-bb2ca66e481e">19.8</ix:nonFraction> million, $<ix:nonFraction unitRef="usd" contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk1MA_1321585e-2d0c-409f-9caf-1d7bd798329c">4.7</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk1Nw_81ea2cbc-6a9b-4d08-bc02-7fe2d69ac8e8">6.2</ix:nonFraction> million, respectively. </span></div></ix:continuation><div style="margin-top:9pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">77</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ib965b149918642cba40a74aa813f98f2" continuedAt="i6e14265a03d54656aee4afac076a61fa"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDI_ae220f3a-bd1e-4f83-accf-2483a0317472" escape="true"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a further breakdown of the options outstanding as of December&#160;31, 2018:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"></td><td style="width:25.366864%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:11.313609%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.391716%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.313609%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.313609%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.313609%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.539645%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:14.568047%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Range of exercise prices</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">outstanding</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">remaining&#160; life</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">in&#160;years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercisable</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise&#160;price</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$8.58 - $10.05</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtMS0xLTEtMA_09763811-6b9b-479f-8f20-fad0a0c37bba">184,702</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtMy0xLTEtMA_155013f7-a6aa-4c9e-a473-4f7f45e217aa">1.87</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtNS0xLTEtMA_6214f3bb-ee0e-472e-a8c6-b861d20e0678">10.00</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtNy0xLTEtMA_ae20dc5c-41cc-4372-9406-82e9c57e49a4">184,702</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtOS0xLTEtMA_64178e28-b898-47de-a211-aac59c442f81">10.00</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$10.12 - $12.81</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItMS0xLTEtMA_1ee29ff0-d792-4dea-bad0-9e4d5755cb50">46,510</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItMy0xLTEtMA_b538c56c-4ee2-4f72-923f-10f6ef996dd3">2.92</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItNS0xLTEtMA_adc44775-87d1-4bee-84aa-a9420b0d3c24">11.40</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItNy0xLTEtMA_0f9c2a78-5700-4ccc-b2f9-c2043163e6d3">46,510</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItOS0xLTEtMA_66d4ecf7-a0e4-48e1-82c5-84854d018f81">11.40</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$14.47 - $14.47</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtMS0xLTEtMA_2da2da54-db26-493e-a981-5e0af13d9c41">217,616</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtMy0xLTEtMA_f7802f34-a0f5-4d0a-87a1-8efd76db8ef0">3.11</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtNS0xLTEtMA_25ae2a25-05fa-47aa-a2ed-b0ebfa6a94dd">14.47</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtNy0xLTEtMA_7b3ef50a-ab15-4d0b-8cf4-439370af783d">203,616</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtOS0xLTEtMA_c50a0448-3245-4ec3-8d5b-e140b994777d">14.47</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$16.14 - $17.88</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtMS0xLTEtMA_943fd8b7-fbc1-4c1f-b01d-fe2a5bd1c155">38,790</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtMy0xLTEtMA_1983ed97-2ebf-4184-b01a-1df559d78ad0">0.17</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtNS0xLTEtMA_25c945fe-d0a2-49f3-a1e0-f7ad96059a35">16.36</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtNy0xLTEtMA_43348d23-9043-4d65-a2dd-a13818cd9686">38,790</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtOS0xLTEtMA_320fdcd1-118f-478b-af71-0b0bf6ce8bd8">16.36</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$21.92 - $21.92</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtMS0xLTEtMA_b96a8eb2-c648-4d74-937d-ec00c24f2e70">200,372</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtMy0xLTEtMA_cd26258b-aa6e-4bd1-afeb-3980f7f7e52d">4.13</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtNS0xLTEtMA_6d1f6473-9747-4708-be45-0bf19d648867">21.92</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtNy0xLTEtMA_d080bb6a-11ed-474c-8ee8-5ef180be1f30">200,372</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtOS0xLTEtMA_33dbec29-d80b-4a2a-8c22-d5caa5905d61">21.92</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$32.00 - $56.26</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtMS0xLTEtMA_be2f1118-3f29-427e-a081-77dd1d690ed1">182,767</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtMy0xLTEtMA_cd83eadd-8504-4408-b583-ad4e268a5c94">5.70</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtNS0xLTEtMA_b18d7649-d5cd-4c3d-81d3-fcd0901dced8">50.38</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtNy0xLTEtMA_24f7073e-0391-4e05-8cb9-b6a82bab6da0">174,470</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtOS0xLTEtMA_829899a8-6f09-4e9b-8e62-0709d53074ce">50.10</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$63.58 - $67.53</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i161b18328a8442d6997ff80696b788bd_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctMS0xLTEtMA_984b7d66-38a8-43f0-a3f2-d1973eb48e81">20,434</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctMy0xLTEtMA_dc3953c1-e558-4dbe-a9f2-b3dd23a508b8">5.44</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i161b18328a8442d6997ff80696b788bd_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctNS0xLTEtMA_ad252db9-0a96-4bce-b712-6c249858c0d8">67.42</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i161b18328a8442d6997ff80696b788bd_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctNy0xLTEtMA_c88c0657-806f-4d46-ba64-0c109f301593">20,153</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i161b18328a8442d6997ff80696b788bd_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctOS0xLTEtMA_0f03298a-d655-4d21-bd72-2229c4143afa">67.47</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$74.42 - $74.42</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i4246c537469d483abd783cecc40379d0_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtMS0xLTEtMA_50dd8ba1-50ca-419b-8b81-26bea2647016">190,825</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtMy0xLTEtMA_e4b74d26-4df4-41ee-be37-79988ed530ad">5.12</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i4246c537469d483abd783cecc40379d0_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtNS0xLTEtMA_253c1a56-65ec-4120-8287-d8c6d7cca605">74.42</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i4246c537469d483abd783cecc40379d0_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtNy0xLTEtMA_0bb4eb5c-fa58-400a-82f1-1219de7da05d">190,825</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i4246c537469d483abd783cecc40379d0_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtOS0xLTEtMA_5c7c0f5f-4ca6-4f63-8211-55f1642afeba">74.42</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$85.79 - $100.38</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktMS0xLTEtMA_4ca3032d-4f81-4e2b-9d6f-e26cb2c25ea5">299,282</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktMy0xLTEtMA_b12501e3-6ea5-4508-93b6-ae0507c00048">7.57</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktNS0xLTEtMA_b2297c5e-525a-445a-8541-70ae1b29543d">93.32</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktNy0xLTEtMA_d8a2c2ad-194c-4d3a-aec4-7e326a579d46">157,872</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktOS0xLTEtMA_32db895c-9109-41f3-80bf-12d39468bdb3">91.62</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$101.15 - $195.91</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTEtMS0xLTA_062387dc-9e55-4db1-b1e7-9c7323dcd5c5">353,006</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTMtMS0xLTA_1cdf7b00-eb75-486f-8daf-7a0279c57161">8.79</ix:nonNumeric></span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTUtMS0xLTA_d56874df-7f7e-4fcf-854e-c51243b20550">148.50</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTctMS0xLTA_7a05ca30-d117-40b0-b85e-0a1dcd9adf51">96,064</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTktMS0xLTA_0858d52a-482e-4a8f-a9cc-21d34a3b5158">131.77</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTEtMS0xLTA_08b7b253-aa18-4419-8e54-b33ef7e31730">1,734,304</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonNumeric contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTMtMS0xLTA_cf192bca-5013-4d43-9b91-0dd1c3dcc9d0">5.47</ix:nonNumeric></span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTUtMS0xLTA_ac46b05c-75da-4a35-a746-244d93506033">66.71</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTctMS0xLTA_a01dcb72-d5bd-4161-a72f-33beb8cbbbab">1,313,374</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231" decimals="2" name="us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTktMS0xLTA_25d96541-6064-435d-9926-1528b5b5ffff">47.03</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDE_001bdf31-90bb-4754-bc87-9d2944eea56e" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.538012%;"><tr><td style="width:1.0%;"></td><td style="width:51.709199%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:12.540059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.986944%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.540059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.541840%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:12.540059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.541840%;"></td><td style="width:0.1%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="18" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.7%-3.0%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0%-2.2%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.3%-1.9%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected volatility</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33%-36%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43%-47%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">48%-50%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected term</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.1 to 5.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.5 to 6.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.6 to 6.7 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr></table></div></ix:nonNumeric><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, there was $<ix:nonFraction unitRef="usd" contextRef="ia0d63b23666041d7a8b08537e54a6d2c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzEyMzk_4f8b1f26-770c-4be0-bed1-20cb4617045a">20.4</ix:nonFraction> million of total unrecognized compensation cost related to non-vested stock options.  That cost is expected to be recognized over a weighted average period of <ix:nonNumeric contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzEzOTM_f6e6adfc-562b-424a-b501-a6ae3445a132">2.39</ix:nonNumeric> years.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Restricted Stock Activity</span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDA_c46a9ec7-1c86-4a23-8f5f-e0d300f330a7" escape="true"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following is a summary of our restricted stock activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:71.127753%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.628488%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:11.509545%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted-Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Grant&#160;Date Fair</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="id920233585164484842655792fe0311e_I20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzEtMS0xLTEtMA_47dd5363-45d0-4712-be56-0775fc0c6395">133,294</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="id920233585164484842655792fe0311e_I20171231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzEtMy0xLTEtMA_a382e64b-e0ab-44c4-adc5-6dec35a2f8e9">91.60</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzItMS0xLTEtMA_a3cc9c52-63b7-4d6e-83ba-67011823915d">62,133</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzItMy0xLTEtMA_4ab1e231-3f38-4b88-935d-7b588237d824">169.92</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vested</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzMtMS0xLTEtMA_7864abb5-107e-4c9b-b353-fb0c731cd4e4">61,989</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzMtMy0xLTEtMA_21ab5464-5cd7-451f-b7f7-a4400999ff7a">86.19</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="shares" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzQtMS0xLTEtMA_0ee22e4e-93e3-4eb2-8f5d-efed0eab10f6">1,165</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzQtMy0xLTEtMA_8557694a-c68e-4562-b596-db014df3499d">125.16</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzUtMS0xLTEtMA_8f214703-7178-45d1-a57f-db5d9a984238">132,273</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231" decimals="2" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzUtMy0xLTEtMA_e4278283-b006-4b4b-8194-9f6cb73b2f49">130.63</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, unrecognized compensation cost related to non-vested stock awards amounted to $<ix:nonFraction unitRef="usd" contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE2MTQ_9b3a348b-92b9-4d5a-bf20-238a32b35017">9.2</ix:nonFraction>&#160;million. That cost is expected to be recognized over a weighted average period of&#160;<ix:nonNumeric contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231" format="ixt-sec:duryear" name="us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE2OTE_6b4ce40b-1b17-4218-b721-38126b61d3f2">1.38</ix:nonNumeric> years.</span></div><div style="text-indent:24pt;"><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Employee Stock Purchase Plan</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2018, <ix:nonFraction unitRef="shares" contextRef="i5049cfdd90d748e48259538705c3a2a0_I20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE3NjE_ff878e6f-1057-4e80-ad76-67bed1182219">64,008</ix:nonFraction> shares of our common stock are available for future issuance under the Amended Employee Stock Purchase Plan, or ESPP.  The ESPP permits eligible employees to purchase up to <ix:nonFraction unitRef="shares" contextRef="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE5NDg_da5a36ec-18d3-42d5-9802-45d42a3d5631">1,250</ix:nonFraction> shares of Ligand common stock per calendar year at a discount through payroll deductions. The price at which stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first of a six month offering period or purchase date, whichever is lower. There were <ix:nonFraction unitRef="shares" contextRef="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNDg_91efb899-a98e-44be-b387-30ec4b1bd65e">3,386</ix:nonFraction>, <ix:nonFraction unitRef="shares" contextRef="ic36cfb515c93422e90d0bdcd8bd0ebee_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNTI_25ee3fa1-e855-4c9f-9cd9-ba98b52afb6b">3,061</ix:nonFraction> and <ix:nonFraction unitRef="shares" contextRef="i6ec79fc5ae034975bdc7a82825400a68_D20160101-20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNTk_28abb155-6fff-4967-90fa-a37c047bbdd4">1,961</ix:nonFraction> shares issued under the ESPP in 2018, 2017 and 2016, respectively. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share Repurchases </span></div></ix:continuation><div style="text-indent:36pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">78</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i6e14265a03d54656aee4afac076a61fa" continuedAt="ia92f2e73f39846fc9cb28c7e225f199d">In May 2018, in conjunction with our&#160;2023 Notes debt offering,&#160;we repurchased <ix:nonFraction unitRef="shares" contextRef="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyMjE_69309b25-4255-4eaf-bb62-3a6a4359ff3d">260,000</ix:nonFraction> shares of our&#160;common stock at&#160;a cost of $<ix:nonFraction unitRef="usdPerShare" contextRef="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531" decimals="2" name="us-gaap:AcceleratedShareRepurchasesFinalPricePaidPerShare" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNDY_ebedcc6d-b652-453e-95a5-129195256f7d">191.14</ix:nonFraction> per share. In September 2018, the&#160;board of directors authorized us to repurchase up to $<ix:nonFraction unitRef="usd" contextRef="ibb568ab64b614ed6a1e37b60e92b6fef_I20150930" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchaseProgramAuthorizedAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyMzA_a893af4e-f1f1-41ae-8090-87b9b41b3865">200.0</ix:nonFraction> million of our common stock&#160;from time to time over a period of up to three years&#160;(the &#8220;Repurchase Program&#8221;). As of December 31, 2018, $<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNTU_3f553585-5a4c-49e6-924a-2701c042490a">125.2</ix:nonFraction> million remains available for repurchase under the&#160;authorized program.&#160;On January 23, 2019, the board of directors elected to increase the Repurchase Program, authorizing us to repurchase up to a maximum of $<ix:nonFraction unitRef="usd" contextRef="if2c884f969ea4a8c957cc0b0ecc3ad55_I20190123" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchaseProgramAuthorizedAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNzI_ae4f0c45-6b87-490b-a39c-d65fadb1a528">350.0</ix:nonFraction> million of our outstanding common stock under the Repurchase Program. The Repurchase Program will expire, as originally scheduled, on September 20, 2021.&#160;Since December 31, 2018 and as of February 28, 2019, we acquired <ix:nonFraction unitRef="shares" contextRef="i0f29d3370c15467eae1d22610a661a7f_D20190101-20190228" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjIzMTE_c07c86d8-f2a1-45b3-8291-77c60b9fd34f">400,177</ix:nonFraction> additional shares during 2019, and the maximum dollar value of shares that may yet be purchased under the Repurchase Program was $<ix:nonFraction unitRef="usd" contextRef="ia523a50a3e1f4636a3f2c5181779d8ee_I20190228" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:StockRepurchaseProgramAuthorizedAmount1" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjIzMjU_9c66a7ae-64fb-44ce-84d8-09b8bdbfd9ff">225.9</ix:nonFraction> million.</ix:continuation></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="ia92f2e73f39846fc9cb28c7e225f199d">During the years ended December&#160;31, 2018, 2017 and 2016, we repurchased <ix:nonFraction unitRef="shares" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI0MjA_24e158fd-0b94-4163-888b-e169146fd8f0">782,248</ix:nonFraction> shares for $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI0MzQ_c9f487b4-7fb0-4314-ba4e-c66302a8a215">127.5</ix:nonFraction> million, <ix:nonFraction unitRef="shares" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxODM_09a043b8-fe78-4797-9774-c9b13c438199">14,000</ix:nonFraction>&#160;shares for $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxOTU_ce062c3a-1f51-460f-806d-5b6f9da844ad">2.0</ix:nonFraction> million, and&#160;<ix:nonFraction unitRef="shares" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="INF" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodShares" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxODc_4193c9c7-21a0-42f4-bd0e-f979371c0f34">40,500</ix:nonFraction>&#160;shares for&#160;$<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:StockRepurchasedDuringPeriodValue" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxOTI_2ab3cd16-e24a-4723-93a8-503e9b1719db">3.9</ix:nonFraction> million, respectively.</ix:continuation> &#160;</span></div><div id="i_0_507"></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">9. &#160;<ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:LegalMattersAndContingenciesTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MDcvZnJhZzo0OTczMWY0YmY4ZWU0ZWQ2YmI4Mjk2ZmJhYjdjOTRjZC90ZXh0cmVnaW9uOjQ5NzMxZjRiZjhlZTRlZDZiYjgyOTZmYmFiN2M5NGNkXzk4OTU2MDQ2NTgyMTU_34d09888-f9c3-4719-8b15-85da84e64e7e" continuedAt="i41004ecea714477791cbd91c8e673810" escape="true">Commitment and Contingencies: Legal Proceedings</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i41004ecea714477791cbd91c8e673810" continuedAt="i8f725b10faf64ab1a9f22eba40c8a3e5"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We record an estimate of a loss when the loss is considered probable and estimable. Where a liability is probable and there is a range of estimated loss and no amount in the range is more likely than any other number in the range, we record the minimum estimated liability related to the claim in accordance with </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">ASC 450, Contingencies</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">. As additional information becomes available, we assess the potential liability related to our pending litigation and revises our estimates. Revisions in the our estimates of potential liability could materially impact our results of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On July 27, 2018, AG Oncon, LLC, AG Ofcon, Ltd., Calamos Market Neutral Income Fund, Capital Ventures International, Citadel Equity Fund Ltd., Opti Opportunity Master Fund, Polygon Convertible Opportunity Master Fund, Wolverine Flagship Fund Trading Limited, as plaintiffs, filed a complaint in the Court of Chancery of the State of Delaware (AG Oncon, LLC v. Ligand Pharmaceuticals Inc.) alleging claims for violation of the Trust Indenture Act, breach of contract, damages and a declaratory judgment that the Supplemental Indenture, dated as of February 20, 2018, entered into by us and Wilmington Trust, National Association, as trustee, is invalid. On October 1, 2018, we filed a motion to dismiss the plaintiffs&#8217; complaint. The hearing on our motion is currently scheduled for April 3, 2019. We believe the allegations are completely without merit, reject all claims raised by the plaintiffs and intend to vigorously defend this matter.</span></div></ix:continuation><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"><ix:continuation id="i8f725b10faf64ab1a9f22eba40c8a3e5">In November 2017, CyDex, our wholly owned subsidiary, received a paragraph IV certification from Teva alleging that certain of our patents related to Captisol were invalid, unenforceable and/or will not be infringed by Teva&#8217;s ANDA related to Spectrum Pharmaceuticals&#8217; NDA for Evomela. On December 20, 2017, CyDex filed a complaint against Teva in the U.S. District Court for the District of Delaware, asserting that Teva&#8217;s ANDA would infringe our patents. On March 22, 2018, Teva filed an answer and counterclaims seeking declarations of non-infringement and invalidity as to each of the asserted patents and on April 12, 2018, CyDex filed an answer to Teva&#8217;s counterclaims. On July 24, 2018, the U.S. District Court entered a Scheduling Order, setting a hearing for April 1, 2019, and a trial may begin in January 2020.</ix:continuation> </span></div><div id="i_0_519"></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">10. <ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:IncomeTaxDisclosureTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0ODU_547c9311-1dda-4913-ba0e-5ce6d7105f04" continuedAt="i2f01c4be387444a1870190baf3284b44" escape="true">Income Taxes</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i2f01c4be387444a1870190baf3284b44" continuedAt="i3a8b14209e0c4adea401998321d908d3"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Tax Act was enacted on December 22, 2017 and includes a number of changes to existing tax laws that impact us, most notably it reduces the US federal corporate tax rate from 35% to 21%, for tax years beginning after December 31, 2017.&#160;The Tax Act made modifications to allowable tax depreciation, the deductability of compensation for officers, the deductibility of meals and entertainment expenses, and the deductibility of interest expense. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We remeasured our deferred tax assets and liabilities based on the impact of the federal tax rate change, recording a decrease to our net deferred tax asset balance and a corresponding increase to our income tax provision of approximately&#160;$<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0OTc1NTgyNjE2Mg_07522b1e-4b46-429a-8f63-ddfa06107f63">0.6</ix:nonFraction> million&#160;and $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" format="ixt:numdotdecimal" name="lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0OTc1NTgxNTEyMDY_1815bf73-9203-4d56-af3d-d4080325a387">32.4</ix:nonFraction> million&#160;for the year ended December 31, 2018&#160;and 2017, respectively.  We completed our accounting for the Tax Act during the fourth quarter of 2018. </span></div></ix:continuation><div></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">79</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i3a8b14209e0c4adea401998321d908d3" continuedAt="ic7df5df081c4417198415797f82ececa"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMjM_65c854ce-fd69-474f-b1b5-dfd9aca58cd9" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The components of the income tax expense (benefit) for continuing operations are as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.976608%;"><tr><td style="width:1.0%;"></td><td style="width:65.503693%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.192024%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.833973%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.192024%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.686263%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.192024%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current expense (benefit):</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:CurrentFederalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMS0xLTEtODcwNQ_85b1dd12-ad44-474a-9aa8-cc086e76a791">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:CurrentFederalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMS0xLTEtMA_4060c872-aeb6-4555-94e9-f0eea1b4e9b0">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:CurrentFederalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMy0xLTEtMA_97065934-ec69-47d3-a675-0d1eadfdd4d7">21</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:CurrentStateAndLocalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMS0xLTEtODcwNw_836c1484-e82e-4a84-b3f7-00bc4c71e834">424</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:CurrentStateAndLocalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMS0xLTEtMA_2d3b9a15-a734-4fa1-87d3-eccb7642beb8">111</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:CurrentStateAndLocalTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMy0xLTEtMA_d5bc6587-8685-4e09-a461-3396d2f710a6">12</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="us-gaap:CurrentForeignTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtMS0xLTEtODcwOQ_e9425a15-ad1d-4b3b-a60d-9aefc04bf77d">158</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:CurrentForeignTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtMS0xLTEtMA_c23f609f-b5ec-4589-b273-e404855a3100">261</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:CurrentForeignTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtNS0xLTEtODcwMg_5cb222af-e8f6-45e1-a101-94a1f6e88d75">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:CurrentIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMS0xLTEtODcxMQ_25c3fb38-15f9-4af4-9907-91b77fb5ed29">266</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:CurrentIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMS0xLTEtMA_c0104f56-05e9-4bf8-84be-d9c03340f785">372</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:CurrentIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMy0xLTEtMA_2d067fef-1e7d-492d-9bdf-d883257dd30c">33</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred expense (benefit):</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredFederalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMS0xLTEtODcxMw_96346def-63cf-46ae-880a-e686abd33c98">29,928</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredFederalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMS0xLTEtMA_3234f63c-e334-41ce-8dc1-d10c765372ad">44,075</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredFederalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMy0xLTEtMA_535af49e-9bca-4cb6-ad22-d661476f1cb7">10,534</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMS0xLTEtODcxNQ_c631dff5-f906-48bb-8a41-61ab13606ebc">185</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMS0xLTEtMA_a7adb7b4-4beb-485a-842f-f1a03f7bbbbd">228</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMy0xLTEtMA_04c95f38-0479-459f-ba52-76a140c364e7">240</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredForeignIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTEtMS0xLTg3MTc_12664b97-c7ff-4066-964a-e6ba21d87259">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredForeignIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTEtMS0xLTA_9afa459b-23b8-41bc-84bd-2443c4902c96">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredForeignIncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTMtMS0xLTA_f1cd708e-641f-441a-8324-b530963094ab">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTEtMS0xLTg3MTk_c158d929-342b-4bda-bbc6-12fab366a0f0">30,009</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTEtMS0xLTA_f2e24dad-619b-4cbc-99c8-f9b9a18b9df7">44,675</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTMtMS0xLTA_2bf04b08-b8b2-4ace-a2fe-a85c8180a742">10,327</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMjk_930ce2ee-e607-47fa-84dd-ff04323b9351" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of income tax expense (benefit) from continuing operations to the amount computed by applying the statutory federal income tax rate to the net income (loss) from continuing operations is summarized as follows (in thousands):</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:65.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.147059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.535294%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.147059%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.682353%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.147059%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax at federal statutory rate</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMS0xLTEtNjI3Mg_2adf5668-95c9-414c-804a-8e55b3b17fe1">36,400</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMS0xLTEtMA_107fbcb4-1b30-4247-a52d-bf62115580d6">20,031</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMy0xLTEtMA_6828216a-3049-4c3b-9df3-54eae13dedd9">2,786</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State, net of federal benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMS0xLTEtNjI4Mg_954d5533-540e-473d-82e7-6165880e9bf4">1,635</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMS0xLTEtMA_508acc0b-9fbd-44c5-8a14-f61ba1dfeb53">622</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMy0xLTEtMA_8f62bc00-f286-465c-838a-3bc5e1a1538c">175</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="lgnd:IncomeTaxReconciliationContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMS0xLTEtNjI4Ng_4cbd1100-3ffa-4e57-a6e6-2e1d5f2a7e0d">948</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="lgnd:IncomeTaxReconciliationContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMS0xLTEtMA_1ad5324a-309b-4fb5-bb1b-e719139dca1f">903</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationContingentValueRights" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMy0xLTEtMA_a40d38de-6559-40f6-a372-136107ef8a22">1,225</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMS0xLTEtNjI5MQ_0f768d80-384e-4e72-ab91-81a4b52539df">8,131</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMS0xLTEtMA_6eaef243-b3a1-4d65-9b74-53b1d5ceef88">4,019</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMy0xLTEtMA_e037b3c0-5585-4633-9e14-93ea4b79c772">263</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMS0xLTEtNjI5NA_c9fb1f28-adf0-4999-8c14-4040598a27f1">2,758</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMS0xLTEtMA_d2bc4a66-a8c6-4ed2-ad59-13cb2d746557">2,821</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMy0xLTEtMA_464bb01b-b53f-44ae-985b-2ecbc569123d">1,525</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in uncertain tax positions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" name="lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMS0xLTEtNjI5OA_17d0039a-145e-4b25-8ab7-1f0d9face552">858</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMS0xLTEtMA_0fe105ae-3cc9-4e26-a1f7-987209353af7">1,308</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMy0xLTEtMA_fe0c251c-137c-4d7d-b335-6b75e7f6ae22">1,423</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Rate change for changes in federal or state law</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMS0xLTEtNjMwMQ_b66b2623-dae8-48ca-83e8-a938d8ae3e23">178</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMS0xLTEtMA_24764b6d-3a9c-4dd3-86a5-d87b1d656c8f">32,429</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMy0xLTEtMA_a5e85590-9898-4358-8034-75b25d7876aa">25</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in valuation allowance</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMS0xLTEtNjMwNQ_defe7c90-68d2-4910-926e-5a0bba01788b">4,225</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMS0xLTEtMA_38a0c0c1-4e34-4a50-900d-4f7091afd90d">4,169</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMy0xLTEtMA_1d1a430d-d891-4139-9502-d8df8e15fd5f">6,283</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expired NOLs and credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationTaxCreditsOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTIxMjgy_7925ac21-60c6-4086-a12f-2416266b376c">3,054</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncomeTaxReconciliationTaxCreditsOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTMtMS0xLTIxNDM1_f252d33e-744d-4e90-bf16-ebeb0263d088">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="us-gaap:IncomeTaxReconciliationTaxCreditsOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTUtMS0xLTIxNDM3_5a5fad73-7661-4154-870f-1924f65264cf">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in derivatives</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTIxMjg2_1a6b71bd-19a2-4e39-83f2-2de2ec41f852">615</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:zerodash" name="lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTMtMS0xLTIxNDMz_1c779846-1007-44ea-995f-64880f3b6933">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:zerodash" name="lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTUtMS0xLTIxNDM5_9177867a-fd0e-4f1c-a12f-3698594f39bf">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxReconciliationOtherAdjustments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTYzMDg_17f19c78-ee84-4f30-886e-04c0a2078d15">1,435</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:IncomeTaxReconciliationOtherAdjustments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTA_094966f3-9c68-4a64-a299-3d8e60c54b20">391</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" sign="-" name="us-gaap:IncomeTaxReconciliationOtherAdjustments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTMtMS0xLTA_b85d761c-d42b-48f3-a7e6-fa2749803c43">328</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTg3MzI_f36530d1-1e41-4ee4-954f-2a2219ff1b67">30,009</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTA_ab513020-90ad-45c5-bb63-6dbcbc9269e4">44,675</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTMtMS0xLTA_a9cd072e-435c-4d67-af1d-68f9219a395d">10,327</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We remeasured certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which is generally 21%. &#160;<ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMzg_3fbbc41b-b794-43a0-888d-ac9f59410038" continuedAt="i7da0a5f3ffdd4ff98c84ef0f8111ddca" escape="true">Significant components of our deferred tax assets and liabilities as of December&#160;31, 2018 and 2017 are shown below. We assess the positive and negative evidence to determine if sufficient future taxable income will be generated to use the existing deferred tax assets. Our evaluation of evidence resulted in management concluding that the majority of our&#160;deferred tax assets will be realized.  However, we maintain a valuation allowance to offset certain net deferred tax assets as management believes realization of such assets are uncertain as of December&#160;31, 2018, 2017 and 2016. The valuation allowance decreased $<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzM4NDgyOTA3MDQzNDI_f2562391-264a-4d18-9e60-bbec61bf27ea">2.5</ix:nonFraction> million in 2018, decreased $<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-5" sign="-" format="ixt:numdotdecimal" name="us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzI5NjE_f77d9ea4-75e9-4b3c-ae68-1835db882e12">8.4</ix:nonFraction> million in 2017 and increased $<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzI5ODM_07a54193-4fb2-47df-8dbc-925646473cee">6.3</ix:nonFraction> million in 2016.</ix:nonNumeric></span></div></ix:continuation><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">80</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="ic7df5df081c4417198415797f82ececa" continuedAt="i0007e0d29acc4f8883d911a760e091fc"><div style="margin-bottom:6pt;"><ix:continuation id="i7da0a5f3ffdd4ff98c84ef0f8111ddca"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.175439%;"><tr><td style="width:1.0%;"></td><td style="width:74.958525%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:9.059908%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.568049%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:9.213518%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands)</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating loss carryforwards</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsOperatingLossCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzQtMS0xLTEtMA_c46b0aff-3c84-4728-a06b-11c42dd4fe3b">57,181</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsOperatingLossCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzQtMy0xLTEtMA_462b7f5c-fd6d-48c0-9c27-1d7829b2e700">90,272</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research credit carryforwards</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsTaxCreditCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzUtMS0xLTEtMA_a0ac560c-2f37-413d-bbfc-19468c3583d9">31,101</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsTaxCreditCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzUtMy0xLTEtMA_c7208675-c6c5-494a-942b-389cb4904583">30,677</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fixed assets and intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzYtMS0xLTEtMA_1abb9486-971e-47f5-a730-70549e27032b">1,637</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzYtMy0xLTEtMA_70af7cbb-bd48-45c9-9840-de038d07367f">1,984</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accrued expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzctMS0xLTEtMA_d5bdcfe9-940a-4a5f-9014-8649f7357bc5">657</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzctMy0xLTEtMA_b100b896-3be8-4175-b6bc-3e69ed3ed14d">845</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="us-gaap:DeferredTaxAssetsDeferredIncome" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzktMS0xLTEtMA_8bef427b-e8ac-4606-b4bd-03d6e25fdda6">957</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:DeferredTaxAssetsDeferredIncome" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzktMy0xLTEtMA_6e8e3ddf-c5d0-41c0-adaf-ef672931fcec">17</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Capital Loss Carryforward</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredTaxAssetsCapitalLossCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEyLTEtMS0xLTA_6dfc3c6a-83d6-4e49-a8cb-193d71903e64">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsCapitalLossCarryforwards" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEyLTMtMS0xLTA_33cd9d18-ad80-457d-acca-0bb17732a734">1,609</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredTaxAssetsEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEzLTEtMS0xLTA_5f8ffa84-db31-41ab-942e-9a4f74723ed4">&#8212;</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsEquityMethodInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEzLTMtMS0xLTA_af80a011-de31-4c59-81af-a3f58248176e">5,137</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE0LTEtMS0xLTA_638e78d1-7d00-421c-b836-b61a2bf124db">11,430</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsOther" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE0LTMtMS0xLTA_60f3a345-00ad-4f8b-8a28-2c245c9d5224">12,499</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE1LTEtMS0xLTA_df8179ba-923f-41e4-9570-cc5af1ee0576">102,963</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsGross" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE1LTMtMS0xLTA_591e865d-3b78-458b-9660-62c5d3e02530">143,040</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Valuation allowance for deferred tax assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsValuationAllowance" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE2LTEtMS0xLTA_e4e3c6cb-eeca-4f75-b5b9-e8801389cc63">4,476</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsValuationAllowance" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE2LTMtMS0xLTA_d411ddde-c2fc-418b-bbb6-6df88b804bce">6,987</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE3LTEtMS0xLTA_4d3e6634-bf99-4a02-b9b4-377a373dd079">98,487</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE3LTMtMS0xLTA_d1bdf4e6-ade2-4658-ab68-c54be22ae18f">136,053</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin fair value adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" name="lgnd:DeferredTaxLiabilitiesFairValueAdjustment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE5LTEtMS0xLTA_8711950e-4c75-404b-9d0b-f719f950017e">179</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="lgnd:DeferredTaxLiabilitiesFairValueAdjustment" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE5LTMtMS0xLTA_f0116818-ff5c-4f01-acf2-e9af6b70545c">243</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Convertible debt</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxLiabilitiesFinancingArrangements" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTEtMS0xLTA_113f2423-d95a-4729-bfab-a4e4b01864c2">2,905</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" name="us-gaap:DeferredTaxLiabilitiesFinancingArrangements" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTMtMS0xLTA_e3eee678-9727-4f42-afaf-fb560b3b63e4">737</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIxLTEtMS0xLTA_13a23a05-ddb4-4250-9547-53c063331f12">44,643</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIxLTMtMS0xLTA_dc0bcac0-43c8-4172-b935-c6a7481bac04">48,237</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified indefinite lived intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTEtMS0xLTA_77e81461-8547-44f7-ac42-887c9879f14f">1,759</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTMtMS0xLTA_fcd31bfd-689e-4c18-98b6-b12f01a52fa6">2,414</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxLiabilitiesInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTEtMS0xLTYzNzU_d8f79ed2-c402-4697-96b8-8e6bff14161d">2,480</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:zerodash" name="us-gaap:DeferredTaxLiabilitiesInvestments" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTMtMS0xLTg4MDQ_bbcd312c-13fb-4bcf-9d09-a0af10b22c9b">&#8212;</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredIncomeTaxLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTEtMS0xLTIxNDQx_609e440b-9e3e-43bc-8962-e67e28af3503">51,966</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredIncomeTaxLiabilities" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTMtMS0xLTIxNDQz_3df98f80-7be5-4207-bbf4-2aced7a314ae">51,631</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred income taxes, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsLiabilitiesNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTEtMS0xLTA_14cd34b6-4627-4b8f-aa07-187260f0c159">46,521</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:DeferredTaxAssetsLiabilitiesNet" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTMtMS0xLTA_e09268fa-a45b-417d-8f5e-488aa81534c9">84,422</ix:nonFraction>&#160;</span></td></tr></table></ix:continuation></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, we had federal net operating loss carryforwards set to expire through 2037 of $<ix:nonFraction unitRef="usd" contextRef="ie84f0fb144ed4ec5926cfdf7ba32b2bb_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:OperatingLossCarryforwards" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMxMzA_c23502d7-b28e-47fd-9baf-4b7b78e2e491">229.9</ix:nonFraction> million and $<ix:nonFraction unitRef="usd" contextRef="if81fb0e1a8ac48909d921d4552f44684_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:OperatingLossCarryforwards" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMxMzc_f63cc76b-98d9-4946-a4eb-201be174c651">125.3</ix:nonFraction> million of state net operating loss carryforwards. We also have&#160;$<ix:nonFraction unitRef="usd" contextRef="ib8f1f80b43fe48948dc666b8a2639468_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:TaxCreditCarryforwardAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMyMDQ_efb32d81-d905-48dd-a019-ec86c123bc67">23.0</ix:nonFraction> million of federal research and development credit carryforwards, which expire through 2037. We have&#160;$<ix:nonFraction unitRef="usd" contextRef="i1426778bb59d4208adce54ccb7e0983f_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:TaxCreditCarryforwardAmount" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMzMDY_7fe64bdb-db7b-442c-a1d6-eedee3c86463">22.7</ix:nonFraction> million of California research and development credit carryforwards that have no expiration date.&#160;&#160; </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Pursuant to Section 382 and 383 of the Internal Revenue Code of 1986, as amended, utilization of our net operating losses and credits may be subject to annual limitations in the event of any significant future changes in its ownership structure. These annual limitations may result in the expiration of net operating losses and credits prior to utilization. The deferred tax assets as of December 31, 2018 are net of any previous limitations due to Section 382 and 383.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for income taxes by evaluating a probability threshold that a tax position must meet before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position. Our remaining liabilities for uncertain tax positions are presented net of the deferred tax asset balances on the accompanying consolidated balance sheet.</span></div><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMzk_de097127-ba6b-42d5-8087-100e2375d732" escape="true"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the amount of unrecognized tax benefits at December&#160;31, 2018, 2017 and 2016 is as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.029240%;"><tr><td style="width:1.0%;"></td><td style="width:64.769231%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.461538%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.569231%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.461538%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.569231%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:8.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at beginning of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItMS0xLTEtMA_7c56449a-4a90-493a-960b-ac4c660fb38a">29,363</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItMy0xLTEtMA_8d1e6d6e-0a4c-4be3-878d-8505a7ad19e6">38,770</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItNS0xLTEtMA_1dc0bab5-ca6d-4161-8b9b-c741e9261006">36,452</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions based on tax positions related to the current year</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtMS0xLTEtMA_9363564d-869d-41ed-b293-0c5ad70e9e71">1,247</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtMy0xLTEtMA_1da0ec23-b976-4cc3-aa80-c86596abc51f">1,067</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtNS0xLTEtMA_5b330613-a6ad-44bc-af13-bd6e36b66a8a">70</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtMS0xLTEtMA_27280b3d-dd79-4cbf-ba96-22eac10ced0b">336</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtMy0xLTEtMA_44a7cc12-627c-44d0-8665-463afa2d1890">109</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtNS0xLTEtMA_f2cfaa84-1fdd-49c2-bb53-e4cec65beaef">2,408</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Reductions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" decimals="-3" name="us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtMS0xLTEtMA_30fd288d-d818-44b1-843d-0f566840d032">657</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtMy0xLTEtMA_87586920-5c2c-4336-a969-1bc9fbfd438b">10,583</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231" decimals="-3" name="us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtNS0xLTEtMA_00d262a5-9c43-43d4-93c9-053988858d9a">160</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at end of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtMS0xLTEtMA_70d1d768-14fd-4b8e-8d8f-cd9f3c42940d">30,289</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtMy0xLTEtMA_6aec27f1-24e9-4b6f-a47b-d1376aa4301d">29,363</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefits" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtNS0xLTEtMA_c2237c0a-69fc-4ca0-90ed-d351f59bf287">38,770</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Included in the balance of unrecognized tax benefits at December&#160;31, 2018 is $<ix:nonFraction unitRef="usd" contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231" decimals="-5" format="ixt:numdotdecimal" name="us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" scale="6" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzQ2MjE_e616864e-3f7b-4125-bdc1-4e6b09bef96a">28.2</ix:nonFraction> million of tax benefits that, if recognized would impact the effective rate. There are no positions for which it is reasonably possible that the uncertain tax benefit will significantly increase or decrease within twelve months.</span></div></ix:continuation><div style="margin-top:9pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">81</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><ix:continuation id="i0007e0d29acc4f8883d911a760e091fc"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize interest and penalties related to uncertain tax positions in income tax expense.  As of December&#160;31, 2018 and December&#160;31, 2017, we recognized an immaterial amount of interest and penalties. We file income tax returns in the United States, various state jurisdictions, United Kingdom, and Canada with varying statutes of limitations. The federal statute of limitation remains open for the 2014 tax year to the present.&#160;The state income tax returns generally remain open for the 2013 tax year through the present.&#160; Net operating loss and research credit carryforwards arising prior to these years are also open to examination if and when utilized.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The IRS began an audit of our 2016 tax year during the quarter ended June 30, 2018. We believe our reserve for unrecognized tax benefits and contingent tax issues is adequate with respect to all open years. Notwithstanding the foregoing, we could adjust our provision for income taxes and contingent tax liability based on future developments.</span></div></ix:continuation><div id="i_0_531"></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">11.&#160;<ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:QuarterlyFinancialInformationTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90ZXh0cmVnaW9uOjFiZjRmNmZkYWFlNTQ0ZmQ4MDVkNmMxZDg4MmUyYTQyXzk4OTU2MDQ2NTAzNTg_cbb50369-86f7-4ca9-9e02-b31f95efc74a" continuedAt="i02b6091a1d7048388a9f96d906771f49" escape="true">Summary of Unaudited Quarterly Financial Information</ix:nonNumeric></span></div><div><span><br/></span></div><ix:continuation id="i02b6091a1d7048388a9f96d906771f49"><ix:nonNumeric contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231" name="us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90ZXh0cmVnaW9uOjFiZjRmNmZkYWFlNTQ0ZmQ4MDVkNmMxZDg4MmUyYTQyXzk4OTU2MDQ2NTAzNTk_e8290a35-237c-4628-9ae5-e2c79ca01829" escape="true"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results and cash flows of interim periods. Summarized quarterly data for 2018 and 2017 are as follows (in thousands, except per share amounts):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"></td><td style="width:45.128130%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.536377%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:10.665685%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">First Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"> Third Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fourth Quarter</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItMS0xLTEtMA_c5b6487c-0cc0-4863-a7db-e48bbf892d66">56,157</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItMy0xLTEtMA_e0f52162-ddd4-4bb8-b615-b3a9504e5366">90,043</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItNS0xLTEtMA_77eabb24-e830-4273-a9de-3a2323a65d47">45,663</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItNy0xLTEtMA_4e4767df-48fc-4040-8f29-8910fa0247b8">59,590</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtMS0xLTEtMA_34f24aa2-b6b0-4927-ac84-72bb30421397">19,116</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtMy0xLTEtMA_38ee773e-293d-4aff-a305-2e4144ea3fc4">19,868</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtNS0xLTEtMA_7941a475-cef8-4cbd-9d2f-9129c4e4f9cc">22,301</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtNy0xLTEtMA_43ac6efc-3665-4791-a6f2-76dd9484969d">26,441</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax (expense) benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtMS0xLTEtMA_2de3c1f9-cd13-4527-bd97-751e1a550135">10,033</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtMy0xLTEtMA_99585706-4c32-4769-b74e-d828e49f7ccb">22,419</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtNS0xLTEtMA_7177d5d7-a18d-4ff2-8656-d00a3701b733">11,864</ix:nonFraction>)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtNy0xLTEtMA_c20dec29-a0c9-45b2-88c0-f9efe7a6719d">14,307</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtMS0xLTEtMA_5a8e812e-bbe2-4f7b-b577-30794b6f19dd">45,279</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtMy0xLTEtMA_75eeb1c2-3941-4601-a314-e6061273e128">73,160</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtNS0xLTEtMA_00806710-1a99-4122-b4de-9ba3c1bb1075">67,362</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtNy0xLTEtMA_d58ee9ea-5654-4198-92ea-f263a5ba039e">42,482</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTEtMS0xLTA_32d95318-6d47-42cd-ada4-aba756f83ab5">2.13</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTMtMS0xLTA_af4e93e6-1653-4fb5-a47e-23e0326d6326">3.45</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTUtMS0xLTA_103ba0cd-10ac-4dc0-8795-9ac14cdc3077">3.19</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="2" sign="-" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTctMS0xLTA_e76fb894-0662-4843-974b-64e198d39249">2.02</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTEtMS0xLTA_6e8d1f71-2c8b-4f30-bad8-dbfa9dbe1d3a">1.83</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTMtMS0xLTA_0987015d-1112-4ca0-b4c1-6bb009750cce">2.99</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTUtMS0xLTA_c5fd65a1-b4f2-4014-8854-ea02cfbe64d6">2.80</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="2" sign="-" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTctMS0xLTA_392964ba-3d23-404b-bbfc-39283cba17ae">2.02</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTEtMS0xLTA_f73691a6-18b3-475f-ae07-80fb23116bc0">21,209</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTMtMS0xLTA_1f45013b-823e-4b17-9fe2-499048ec1714">21,212</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTUtMS0xLTA_1196ca94-e539-478b-9b7d-c95068e1214e">21,148</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTctMS0xLTA_4dab20a6-4e35-4aef-bb72-00af91c10dd0">21,071</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTEtMS0xLTA_00188fdf-2c5e-40d6-a853-cc9fe6fbc8d6">24,800</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTMtMS0xLTA_8c5b3c21-cbdf-491d-b886-a4760e25c8e6">24,438</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTUtMS0xLTA_16cb1d58-225b-43ac-9ac5-c1a620b5c45f">24,052</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTctMS0xLTA_a2c4c7a0-ca50-4bdc-b023-1697df08464d">21,071</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTEtMS0xLTA_a5a2c105-faf0-41b7-aa2f-9edaa393bb4c">29,267</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTMtMS0xLTA_6f01f666-3ede-435e-8995-2a4a872288d0">27,995</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTUtMS0xLTA_72df081c-8b41-46a8-87f3-c2e8c1aef250">33,375</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTctMS0xLTA_a5082f5b-0c73-4c10-af03-b3629ebb8b86">50,465</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTEtMS0xLTA_623910c3-141d-4195-9147-3911c9565bab">19,051</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTMtMS0xLTA_fa09226c-3eb3-46b8-ab23-08421f404a1f">14,980</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTUtMS0xLTA_66682c0c-b384-4d13-b500-3cde94ea28a0">16,882</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:OperatingCostsAndExpenses" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTctMS0xLTA_6851dbe1-a9fc-46b3-a9c2-53834b0ed60c">22,113</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTEtMS0xLTA_3d516052-2ef7-463a-ac1d-4c1e81dc5455">1,114</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTMtMS0xLTA_143bea88-4fbc-4b6f-a09c-3a1a8cd1dd1f">2,242</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTUtMS0xLTA_811227e3-e354-4bc5-af77-edf69a3b84e2">3,645</ix:nonFraction>)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:IncomeTaxExpenseBenefit" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTctMS0xLTA_65845698-41c9-4aed-913e-fca62bb2ceb6">37,674</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTEtMS0xLTA_aac47116-e8bd-4709-b3e0-c4552eed885b">5,079</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTMtMS0xLTA_35e4e348-d47b-4a71-85bf-7dcd4df0f86e">6,058</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usd" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTUtMS0xLTA_6f0ae70d-d19a-4db2-b26c-c01c1fd73a2f">8,426</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usd" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" sign="-" format="ixt:numdotdecimal" name="us-gaap:NetIncomeLoss" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTctMS0xLTA_d62c7598-004d-4740-83a9-422cc89d8545">7,007</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTEtMS0xLTA_09306152-7ea0-402d-9299-852f2961f32f">0.24</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTMtMS0xLTA_6a80e477-3b7c-4b2a-8360-524bc7cf2845">0.29</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="2" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTUtMS0xLTA_aadaa2c1-9860-4bf9-9382-a0564d416bdf">0.40</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="2" sign="-" name="us-gaap:EarningsPerShareBasic" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTctMS0xLTA_fd388af8-bf01-4a76-a39c-f800f6ab0a53">0.33</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTEtMS0xLTA_fbc768b9-0406-4f5d-9032-89a0068a4b13">0.22</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTMtMS0xLTA_05f065fe-1f71-496b-a858-d5b3fff70385">0.26</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="usdPerShare" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="2" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTUtMS0xLTA_061eba63-96f2-4d71-a2ed-bb3b0a2827df">0.36</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(<ix:nonFraction unitRef="usdPerShare" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="2" sign="-" name="us-gaap:EarningsPerShareDiluted" scale="0" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTctMS0xLTA_90f55a03-5cdb-4f76-932e-9dc999a95d5f">0.33</ix:nonFraction>)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTEtMS0xLTA_26221837-da1c-4518-910d-06bc72805e9a">20,938</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTMtMS0xLTA_0f09267f-9430-4da7-938b-eff8cab64b1d">21,013</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTUtMS0xLTA_73571307-bd4b-4794-bf01-8fedc094cd1a">21,071</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfSharesOutstandingBasic" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTctMS0xLTA_227a6ce0-7253-46f1-8911-c9e77d6331f8">21,109</ix:nonFraction>&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTEtMS0xLTA_08dcb08a-8068-4c1f-a689-2f13053ca22d">23,019</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTMtMS0xLTA_2bfa1ec5-50e0-42c8-814c-a4425da9ac86">23,216</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTUtMS0xLTA_4507715e-27c6-43d8-a64f-70636aca738f">23,551</ix:nonFraction>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"><ix:nonFraction unitRef="shares" contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231" decimals="-3" format="ixt:numdotdecimal" name="us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding" scale="3" id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTctMS0xLTA_3fd5ae73-a884-47f4-9e8b-37a4541153a9">21,109</ix:nonFraction>&#160;</span></td></tr></table></div></ix:nonNumeric></ix:continuation><div><span><br/></span></div><div><span><br/></span></div><div id="i_0_543"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;9.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Changes in and Disagreements with Accountants on Accounting and Financial Disclosure</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_555"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;9A.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Controls and Procedures</span></td></tr></table></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(a) Evaluation of Disclosure Controls and Procedures</span></div><div><span><br/></span></div><div style="text-indent:27pt;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">82</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We are responsible for maintaining disclosure controls and procedures designed to provide reasonable assurance that information required to be disclosed in reports we file under the Exchange Act is recorded, processed, summarized and reported within the specified time periods and accumulated and communicated to management, including our Chief Executive Officer and Chief Financial Officer, as appropriate, to allow timely decisions regarding required disclosure. The design of any system of controls is based in part upon certain assumptions about the likelihood of future events, and there can be no assurance that any design will succeed in achieving its stated goals under all potential future conditions; over time, controls may become inadequate because of changes in conditions, or the degree of compliance with policies or procedures may deteriorate. Because of the inherent limitations in a cost-effective control system, misstatements due to error or fraud may occur and not be detected. As of the end of the period covered by this Annual Report on Form 10-K, we have carried out an evaluation, under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, of the effectiveness of our disclosure controls and procedures, as defined in Rules 13a-15(e) and 15d-15(e) under the Exchange Act, and have concluded our disclosure controls and procedures were effective at a reasonable assurance level as of December&#160;31, 2018.</span></div><div style="text-indent:27pt;"><span><br/></span></div><div style="text-indent:27pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">There have been no changes in our internal control over financial reporting that occurred during the quarter ended&#160;December&#160;31, 2018&#160;that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(b) Management&#8217;s Report on Internal Control Over Financial Reporting</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Management is responsible for establishing and maintaining adequate internal control over financial reporting for the Company. Internal control over financial reporting is a process to provide reasonable assurance regarding the reliability of our financial reporting for external purposes in accordance with accounting principles generally accepted in the United States of America. Internal control over financial reporting includes maintaining records that in reasonable detail accurately and fairly reflect our transactions; providing reasonable assurance that transactions are recorded as necessary for preparation of our financial statements in accordance with generally accepted accounting principles; providing reasonable assurance that receipts and expenditures are made in accordance with our management and directors; and providing reasonable assurance that</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">unauthorized acquisition, use or disposition of company assets that could have a material effect on our financial statements would be prevented or detected on a timely basis. Because of its inherent limitations, internal control over financial reporting is not intended to provide absolute assurance that a misstatement of our financial statements would be prevented or detected.</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the supervision and with the participation of our management, including our Chief Executive Officer and Chief Financial Officer, we conducted an evaluation of the effectiveness of our internal control over financial reporting based on the framework established by the COSO as set forth in the 2013 Internal Control-Integrated Framework. Based on our evaluation under the 2013 framework in Internal Control - Integrated Framework, management concluded that our internal controls over financial reporting were effective as of December&#160;31, 2018.</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ernst&#160;&amp; Young LLP, an independent registered public accounting firm, has audited the Company&#8217;s consolidated financial statements included in this Annual Report on Form 10-K and has issued an attestation report, included herein, on the effectiveness of our internal control over financial reporting as of December&#160;31, 2018.</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Report of Independent Registered Public Accounting Firm</span></div><div style="margin-top:6pt;"><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">83</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Board of Directors and Stockholders of Ligand Pharmaceuticals Incorporated</span></div><div style="margin-top:18pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Opinion on Internal Control Over Financial Reporting</span></div><div style="margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have audited Ligand Pharmaceuticals Incorporated&#8217;s internal control over financial reporting as of December 31, 2018, based on criteria established in Internal Control-Integrated Framework&#160;issued by the Committee of Sponsoring Organizations of the Treadway Commission (2013 framework) (the COSO criteria). In our opinion, Ligand Pharmaceuticals Incorporated (the Company) maintained, in all material respects, effective internal control over financial reporting as of December 31, 2018, based on the COSO criteria.</span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We also have audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States) (PCAOB), the consolidated balance sheets of the Company as of December 31, 2018 and 2017, the related consolidated statements of operations, comprehensive income (loss), stockholders&#8217; equity and cash flows for each of the three years&#160;in the period ended December 31, 2018, and the related notes and our report dated&#160;February&#160;28, 2019 expressed an unqualified opinion thereon.</span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Basis for Opinion </span></div><div style="margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Company&#8217;s management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting included in the accompanying Management&#8217;s Report on Internal Control Over Financial Reporting. Our responsibility is to express an opinion on the Company&#8217;s internal control over financial reporting based on our audit. We are a public accounting firm registered with the PCAOB and are required to be independent with respect to the Company in accordance with the U.S. federal securities laws and the applicable rules and regulations of the Securities and Exchange Commission and the PCAOB. </span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We conducted our audit in accordance with the standards of the PCAOB. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects.  </span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audit provides a reasonable basis for our opinion. </span></div><div style="margin-top:18pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Definition and Limitations of Internal Control Over Financial Reporting </span></div><div style="margin-top:6pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A company&#8217;s internal control over financial reporting is a process designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company&#8217;s internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles, and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company&#8217;s assets that could have a material effect on the financial statements. </span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Also, projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.</span></div><div style="margin-top:12pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">/s/ Ernst &amp; Young LLP</span></div><div style="margin-top:12pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">San Diego, California</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</span></div><div style="text-align:center;"><span><br/></span></div><div id="i_0_756"></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">84</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:46.198830%;"><tr><td style="width:1.0%;"></td><td style="width:27.430380%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:68.569620%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item 9B.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other Information</span></td></tr></table></div><div><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None.</span></div><div id="i_0_567"></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Part III</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div id="i_0_580"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;10.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Directors, Executive Officers and Corporate Governance</span></td></tr></table></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Code of Conduct</span></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Board of Directors has adopted a Code of Conduct and Ethics Policy (&#8220;Code of Conduct&#8221;) that applies to all officers, directors and employees. The Company will promptly disclose (1) the nature of any amendment to the Code of Conduct that applies to our principal executive officer, principal financial officer, principal accounting officer or controller or persons performing similar functions and (2) the nature of any waiver, including an implicit waiver, from a provision of our Code of Conduct that is granted to one of these specified officers, the name of such person who is granted the waiver and the date of the waiver on our website in the future. The Code of Conduct can be accessed via our website (http://www.ligand.com), Corporate Overview page. You may also request a free copy by writing to: Investor Relations, Ligand Pharmaceuticals Incorporated, 3911 Sorrento Valley Blvd, Suite 110, San Diego, CA 92121.</span></div><div style="text-indent:27pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The other information under Item&#160;10 is hereby incorporated by reference to Ligand&#8217;s Definitive Proxy Statement to be filed with the SEC within 120 days of December&#160;31, 2018.&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_592"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;11.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Executive Compensation</span></td></tr></table></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Item&#160;11 is hereby incorporated by reference to Ligand&#8217;s Definitive Proxy Statement to be filed with the SEC within 120 days of December&#160;31, 2018.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_604"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;12.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters</span></td></tr></table></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Item&#160;12 is hereby incorporated by reference to Ligand&#8217;s Definitive Proxy Statement to be filed with the SEC within 120 days of December&#160;31, 2018.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_616"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;13.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certain Relationships and Related Transactions, and Director Independence</span></td></tr></table></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Item&#160;13 is hereby incorporated by reference to Ligand&#8217;s Definitive Proxy Statement to be filed with the SEC within 120 days of December&#160;31, 2018.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:14pt;line-height:120%;">&#160;</span></div><div id="i_0_628"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;14.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principal Accountant Fees and Services</span></td></tr></table></div><div style="text-indent:27pt;margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Item&#160;14 is hereby incorporated by reference to Ligand&#8217;s Definitive Proxy Statement to be filed with the SEC within 120 days of December&#160;31, 2018.</span></div><div id="i_0_640"></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">85</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">PART IV</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div id="i_0_653"></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:8.850440%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:87.149560%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item&#160;15.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exhibits and Financial Statement Schedule</span></td></tr></table></div><div style="margin-top:5pt;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">(a) The following documents are included as part of this Annual Report on Form 10-K.</span></div><div style="text-indent:-13.5pt;padding-left:58.5pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) Financial statements</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"></td><td style="width:90.228739%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.771261%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_233">Index to Consolidated Financial Statements</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_233">46</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_245">Report of Independent Registered Public Accounting Firm</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_245">47</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_271">Consolidated Balance Sheets</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_271">48</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_297">Consolidated Statements of Operations</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_297">49</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_309">Consolidated Statements of Comprehensive Income (Loss)</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_309">50</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_321">Consolidated Statements of Stockholders&#8217; Equity (Deficit)</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_321">52</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_334">Consolidated Statements of Cash Flows</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_334">52</a></span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_346">Notes to Consolidated Financial Statements</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:right;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;text-decoration: underline;" href="#i_0_346">54</a></span></div></td></tr></table></div><div style="text-indent:-13.5pt;padding-left:58.5pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(2) Schedules not included herein have been omitted because they are not applicable or the required information is in the consolidated financial statements or notes thereto.</span></div><div style="text-indent:-13.5pt;padding-left:58.5pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(3) The following exhibits are filed as part of this Form 10-K and this list includes the Exhibit Index.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="12" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Incorporated by Reference&#160;</span></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Exhibit</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Number</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Description of Exhibit&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">File Number&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Date of Filing&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Exhibit </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Number</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Filed </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:700;line-height:100%;">Herewith</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000122/omttransaction-mergeragree.htm">2.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Agreement and Plan of Merger, dated as of December 17, 2015, by and among Ligand Pharmaceuticals Incorporated, Open Monoclonal Technology, Inc., OMT, LLC, Schrader 1 Acquisition, Inc., Schrader 2 Acquisition, Inc. and Fortis Advisors LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 18, 2015&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000115/exhibit21-rule27announcment.htm">2.2</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Rule 2.7 Announcement issued by Ligand Holdings UK Ltd., dated August 9, 2018 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 9, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/0000936392-98-001000.txt">3.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amended and Restated Certificate of Incorporation of the Company. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">S-4&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333-58823&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">July 9, 1998&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616301000008/0000886163-01-000008-0002.txt">3.2</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company, dated June 14, 2000 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0-20720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 29, 2001&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.5&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616304000015/ex3-6.txt">3.3</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company, dated June 30, 2004 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0-20720&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 5, 2004&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312510264942/dex31.htm">3.4</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certificate of Amendment of the Amended and Restated Certificate of Incorporation of the Company, dated November 17, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">November&#160;19, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000097/thirdamendedandrestatedbyl.htm">3.5</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Third Amended and Restated Bylaws of the Company&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">September 10, 2015&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/lgndexhibi41.htm">4.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Specimen stock certificate for shares of the common stock of the Company&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 1, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex41.htm">4.2</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indenture dated August 18, 2014 between the Company and Wilmington Trust, National Association &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000106/exhibit.htm">4.3</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supplemental Indenture, dated as of February 20, 2018, between the Company and Wilmington Trust, National Association, as trustee&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">July 30, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/exhibit42.htm">4.4</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Supplemental Indenture, dated as of May 22, 2018, between the Company and Wilmington Trust, National Association, as trustee&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/exhibit41.htm">4.5</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indenture, dated as of May 22, 2018, between the Company and Wilmington Trust, National Association, as trustee, including the form of 0.75% Convertible Senior Notes due 2023&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">86</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516664653/d164308dex101.htm">10.1#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2002 Stock Incentive Plan (as amended and restated through May 23, 2016)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">S-8&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333-212775&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">July 29, 2016 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312509134320/dex102.htm">10.2#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2002 Employee Stock Purchase Plan (as amended effective July 1, 2009)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">S-8&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333-160132&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 22, 2009&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000031/lgnd-ex105_optionagreement.htm">10.3#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Stock Option Grant Notice and Stock Option Agreement under the Company&#8217;s 2002 Stock Incentive Plan&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 24, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.5&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w289.txt">10.4#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Stock Issuance Agreement for non-employee directors under the Company&#8217;s 2002 Stock Incentive Plan</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">S-1</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333-131029</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;13, 2006</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.289&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000093639207000206/a28325exv10w309.htm">10.5#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Letter Agreement regarding Change of Control Severance Benefits between the Company and its officers</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 16, 2007</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.309&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/formofrsugrantnoticeexhibi.htm">10.6#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement under the Company&#8217;s 2002 Stock Incentive Plan &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 1, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/lgnd-rsugrantnoticeperform.htm">10.7#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Restricted Stock Unit Grant Notice and Restricted Stock Unit Agreement under the Company&#8217;s 2002 Stock Incentive Plan - Performance-Based RSU Form</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 1, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.7&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616307000132/ex10-1.txt">10.8#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Executive Officer Change in Control Severance Agreement &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August&#160;22, 2007&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312508260208/dex102.htm">10.9#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amended and Restated Severance Plan, dated December 20, 2008&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;24, 2008</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">10.1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">0</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research, Development and License Agreement, dated December 29, 1994, between SmithKline Beecham Corporation and the Company .&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;">S-1</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;">S-3</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;">33-87598</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;">33-87600</span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;20, 1994&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">10.1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;" href="http://www.sec.gov/Archives/edgar/data/886163/000095013706000420/a16037orexv10w287.txt">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amended and Restated Research, Development and License Agreement, dated December 1, 2005, between the Company and Wyeth (formerly American Home Products Corporation)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">S-1&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">333-131029&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;13, 2006 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.287&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312509107397/dex10318.htm">10.12</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Settlement Agreement and Mutual Release, by and between the Company and The Rockefeller University, dated February 11, 2009 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 11, 2009&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.318&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312510015242/dex102.htm">10.13</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">TR Beta Contingent Value Rights Agreement, dated January 27, 2010, among the Company, Metabasis Therapeutics, Inc., David F. Hale and Mellon Investor Services LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;28, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312510015242/dex103.htm">10.14</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Glucagon Contingent Value Rights Agreement, dated January 27, 2010, among the Company, Metabasis Therapeutics, Inc., David F. Hale and Mellon Investor Services LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;28, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.3&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312510015242/dex104.htm">10.15</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General Contingent Value Rights Agreement, dated January 27, 2010, among the Company, Metabasis Therapeutics, Inc., David F. Hale and Mellon Investor Services LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;28, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.4&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511018895/dex101.htm">10.16</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment of General Contingent Value Rights Agreement, dated January 26, 2011, among the Company, Metabasis Therapeutics, Inc., David F. Hale and Mellon Investor Services LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">January&#160;31, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10100.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10100.htm">1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10100.htm">7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10100.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Captisol&#174; Supply Agreement, dated December&#160;20, 2002, among CyDex, Inc., Hovione&#160;LLC, Hovione FarmaCiencia&#160;S.A., Hovione Pharmascience Limited and Hovione International Limited &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10101.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10101.htm">1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10101.htm">8</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1st Amendment to Captisol&#174; Supply Agreement, dated July&#160;29, 2005, among CyDex, Inc., Hovione&#160;LLC, Hovione FarmaCiencia&#160;S.A., Hovione Pharmascience Limited and Hovione International Limited &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.101&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10102.htm">10.19</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2nd&#160;Amendment to Captisol&#174; Supply Agreement, dated March&#160;1, 2007, among CyDex, Inc., Hovione&#160;LLC, Hovione FarmaCiencia&#160;S.A., Hovione Pharmascience Limited, and Hovione International Limited &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.102&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10103.htm">10.2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10103.htm">0</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10103.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3rd&#160;Amendment to Captisol&#174; Supply Agreement, dated January&#160;25, 2008, among CyDex, Inc., Hovione&#160;LLC, Hovione FarmaCiencia&#160;S.A., Hovione Pharmascience Limited, and Hovione International Limited &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.103&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">87</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10104.htm">10.21&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4th&#160;Amendment to Captisol&#174; Supply Agreement, dated September 28, 2009, among CyDex Pharmaceuticals, Inc., Hovione&#160;LLC, Hovione FarmaCiencia&#160;S.A., Hovione Pharmascience Limited and Hovione International Limited &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.104&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10105.htm">10.2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10105.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10105.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License Agreement, dated September&#160;3, 1993, between CyDex L.C. and The University of Kansas &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.105&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10107.htm">10.2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10107.htm">3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10107.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Amendment to License Agreement, dated August&#160;4, 2004, between CyDex, Inc. and The University of Kansas &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.107&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10111.htm">10.2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10111.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10111.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Acknowledgement Agreement, dated February 22, 2008, between CyDex, Inc. and The University of Kansas &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.111&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10108.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10108.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10108.htm">5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10108.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exclusive License Agreement, dated June&#160;4, 1996, between Pfizer,&#160;Inc. and The University of Kansas &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.108&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10110.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10110.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10110.htm">6</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10110.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Addendum to Nonexclusive License Agreement, dated December&#160;11, 2001, between CyDex, Inc. and Pfizer,&#160;Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.11&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10112.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10112.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10112.htm">7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10112.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License Agreement, dated January 4, 2006, between CyDex, Inc. and Prism Pharmaceuticals, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.112&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10113.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10113.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10113.htm">8</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10113.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment to License Agreement, dated May 12, 2006, between CyDex, Inc. and Prism Pharmaceuticals, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.113&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10114.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10114.htm">29</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511055119/dex10114.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supply Agreement, dated March 5, 2007, between CyDex, Inc. and Prism Pharmaceuticals, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 3, 2011&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.114&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/1012140/000095012310015780/f55044exv10w22.htm">10.3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/1012140/000095012310015780/f55044exv10w22.htm">0</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/1012140/000095012310015780/f55044exv10w22.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License and Supply Agreement, dated October 12, 2005, between CyDex Pharmaceuticals, Inc. and Proteolix, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">000-28298&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 23, 2010&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.22&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511214243/dex1027.htm">10.3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511214243/dex1027.htm">1</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312511214243/dex1027.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supply Agreement, dated June 13, 2011 by and between CyDex Pharmaceuticals, Inc. and Merck Sharp &amp; Dohme Corporation &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q/A</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">November 2, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.26&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumlicenseagreement-e.htm">10.3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumlicenseagreement-e.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumlicenseagreement-e.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License Agreement, by and between CyDex Pharmaceuticals, Inc. and Spectrum Pharmaceuticals, Inc., dated as of March 8, 2013 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 8, 2013&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumsupplyagreement-ex.htm">10.3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumsupplyagreement-ex.htm">3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000040/spectrumsupplyagreement-ex.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Supply Agreement, by and between CyDex Pharmaceuticals, Inc. and Spectrum Pharmaceuticals, Inc., dated as of March 8, 2013 &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 8, 2013&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.3&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000078/ligand-selexisroyaltystrea.htm">10.3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000078/ligand-selexisroyaltystrea.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616313000078/ligand-selexisroyaltystrea.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalty Stream and Milestone Payments Purchase Agreement, dated April 29, 2013, between the Company and Selexis S.A. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 1, 2013&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000057/amendment_ofxgeneralxcvrxa.htm">10.35</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment of &#8220;General&#8221; Contingent Value Rights Agreement dated May 20, 2014 among the Company, Metabasis Therapeutics, Inc., David F. Hale and Computershare Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000057/amendment_ofxtrxbetaxcvrxa.htm">10.36</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment of &#8220;TR Beta&#8221; Contingent Value Rights Agreement dated May 20, 2014 among the Company, Metabasis Therapeutics, Inc., David F. Hale and Computershare, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000090/ligand-vikingxmasterlicens.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000090/ligand-vikingxmasterlicens.htm">3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000090/ligand-vikingxmasterlicens.htm">7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000090/ligand-vikingxmasterlicens.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Master License Agreement dated May 21, 2014 among the Company, Metabasis Therapeutics, Inc. and Viking Therapeutics, Inc.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 5, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex101.htm">10.38</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 12, 2014, between Bank of America, N.A. and the Company regarding the Base Convertible Note Hedge Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex102.htm">10.39</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 12, 2014, between Bank of America, N.A. and the Company regarding the Base Issuer Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex103.htm">10.40</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 12, 2014, between Deutsche Bank AG, London Branch and the Company regarding the Base Convertible Bond Hedge Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.3&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex104.htm">10.41</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 12, 2014, between Deutsche Bank AG, London Branch and the Company regarding the Base Issuer Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.4&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">88</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex105.htm">10.42</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 14, 2014, between Bank of America, N.A. and the Company regarding the Additional Convertible Bond Hedge Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.5&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex106.htm">10.43</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 14, 2014, between Bank of America, N.A. and the Company regarding the Additional Issuer Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex107.htm">10.44</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 14, 2014, between Deutsche Bank AG, London Branch and the Company regarding the Additional Convertible Bond Hedge Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.7&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312514313479/d775802dex108.htm">10.45</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of August 14, 2014, between Deutsche Bank AG, London Branch and the Company regarding the Additional Issuer Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 18, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.8&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000110/lgnd-vikingxamendmentno1to.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000110/lgnd-vikingxamendmentno1to.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000110/lgnd-vikingxamendmentno1to.htm">6</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000110/lgnd-vikingxamendmentno1to.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">First Amendment to Master License Agreement dated September 6, 2014 among the Company, Metabasis Therapeutics, Inc. and Viking Therapeutics, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">October 31, 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.9&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000085/lgndvikingmasterlicenseagr.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000085/lgndvikingmasterlicenseagr.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000085/lgndvikingmasterlicenseagr.htm">7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616315000085/lgndvikingmasterlicenseagr.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Amendment to Master License Agreement, dated April 8, 2015, among the Company, Metabasis Therapeutics, Inc. and Viking Therapeutics, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 5, 2015&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit1048-.htm">10.48</a></span><span style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616314000090/ligand-vikingxloanandsecur.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Development Funding and Royalties Agreement, dated December 13, 2018, by and between Ligand Pharmaceuticals Incorporated and Palvella Therapeutics, Inc.<br/>&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312512209934/d335104dex101.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312512209934/d335104dex101.htm">49</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312512209934/d335104dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sublicense Agreement between the Company, Pharmacopeia, Inc. and Retrophin LLC dated as of February 16, 2012.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 4. 2012&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515412803/d104147dex101.htm">10.5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515412803/d104147dex101.htm">0</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515412803/d104147dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment No. 4 to Sublicense Agreement, dated September 17, 2015, among the Company, Pharmacopeia, LLC and Retrophin, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q/A&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 23, 2015&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000063/lgnd-ctrxretrophinredacted.htm">10.51</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment No. 5 to Sublicense Agreement, dated March 20, 2018, among the Company, Pharmacopeia, LLC and Retrophin, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 9. 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515372802/d30180dex101.htm">10.5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515372802/d30180dex101.htm">2</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312515372802/d30180dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lease, dated November 3, 2015, between the Company and 3911/3931 SVB, LLC &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">November 10, 2015&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616316000245/dircompex101.htm">10.5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616316000245/dircompex101.htm">3</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616316000245/dircompex101.htm">#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amended and Restated Director Compensation and Stock Ownership Policy, effective as of March 2014&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">November 14, 2016&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="margin-top:2pt;margin-bottom:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">10.5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Interest Purchase Agreement, dated May 3, 2016, between the Company and CorMatrix Cardiovascular, Inc.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K/A&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 9, 2016&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616317000091/ex102lgndcormatrixarinte.htm">10.55</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amended and Restated Interest Purchase Agreement, dated May 31, 2017, between the Company and CorMatrix Cardiovascular, Inc. &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-033093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 9, 2017&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000063/finalligand-roivantgralice.htm">10.56</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License Agreement, dated March 5, 2018, between the Company and Roivant Sciences GmbH&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 9, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex101-basebondhedgebc.htm">10.57</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Barclays Capital Inc. and the Company regarding the Base Convertible Note Hedge Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex102-basewarrantbc.htm">10.58</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Barclays Capital Inc. and the Company regarding the Base Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.2&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex103-basebondhedgedb.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex103-basebondhedgedb.htm">59</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Deutsche Bank AG and the Company regarding the Base Convertible Note Hedge Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.3&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex104-basewarrantdb.htm">10.60</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Deutsche Bank AG and the Company regarding the Base Warrant Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.4&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">89</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex105-basebondhedgegs.htm">10.61</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Goldman Sachs &amp; Co. LLC and the Company regarding the Base Convertible Note Hedge Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.5&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex106-basewarrantgs.htm">10.62</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 17, 2018, between Goldman Sachs &amp; Co. LLC and the Company regarding the Base Warrant Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex107-bondhedgebc.htm">10.63</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Barclays Capital Inc. and the Company regarding the Additional Convertible Note Hedge Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.7&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex108-additionalwarrantbc.htm">10.64</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Barclays Capital Inc. and the Company regarding the Additional Warrant Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.8&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex109-bondhedgedb.htm">10.65</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Deutsche Bank AG and the Company regarding the Additional Convertible Note Hedge Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.9&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex1010-additionalwarrantdb.htm">10.66</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Deutsche Bank AG and the Company regarding the Additional Warrant Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex1011-bondhedgegs.htm">10.67</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Goldman Sachs &amp; Co. LLC and the Company regarding the Additional Convertible Note Hedge Transaction&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.11&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000076/ex1012-additionalwarrantgs.htm">10.68</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Letter Agreement, dated as of May 18, 2018, between Goldman Sachs &amp; Co. LLC and the Company regarding the Additional Warrant Transaction &#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-00393&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">May 22, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.12&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="margin-top:2pt;margin-bottom:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000113/a101redlineplatformlicen.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000113/a101redlineplatformlicen.htm">69</a></span><span style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Platform License Agreement, dated March 23, 2015, by and between Open Monoclonal Technology, Inc. and WuXi AppTec Biopharmaceuticals Co., Ltd.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 8, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.13&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="margin-top:2pt;margin-bottom:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000113/a1014redlineamendmentnum.htm">10.70</a></span><span style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment Number 1 to Platform License Agreement, dated June 11, 2017, by and between Open Monoclonal Technology, Inc. and WuXi Biologics (Hong Kong) Limited (as successor-in-interest to WuXi AppTec Biopharmaceuticals Co., Ltd.)&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 8, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.14&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="margin-top:2pt;margin-bottom:2pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000113/a1015redlineamendmentnum.htm">10.71</a></span><span style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000ff;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000119312516582835/d178557dex101.htm">&#8224;</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amendment Number 2 to Platform License Agreement, dated June 25, 2018, by and between Open Monoclonal Technology, Inc. and WuXi Biologics Ireland Limited (as successor-in-interest to WuXi Biologics (Hong Kong) Limited).&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-Q&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 8, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.15&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000115/exhibit101co-operationagre.htm">10.72</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cooperation Agreement, dated August 9, 2018, by and between Vernalis plc and Ligand Holdings UK Ltd.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 8, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000115/exhibit101co-operationagre.htm">10.73</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Break Fee Agreement, dated August 9, 2018, by and between Vernalis plc and Ligand Holdings UK Ltd.&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 8, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">10.7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">4</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Indemnification Agreement between the Company and each of its directors</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 1, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.60&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">10.</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">7</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">5</a><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="http://www.sec.gov/Archives/edgar/data/886163/000088616318000030/indemnificationagreement-d.htm">#</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form of Indemnification Agreement between the Company and each of its officers</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10-K&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">001-33093&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">March 1, 2018&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.60&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"></span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit211-n.htm">21.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Subsidiaries of the Company &#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit231-n.htm">23.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Consent of independent registered public accounting firm-Ernst &amp; Young LLP&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit311-n.htm">31.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certification by Principal Executive Officer, Pursuant to Rules 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit312-n.htm">31.2</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certification by Principal Financial Officer, Pursuant to Rules 13a-14(a) and 15d-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X&#160;</span></td></tr></table></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;-sec-extract:summary;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">90</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"></td><td style="width:8.000000%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:34.764706%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:5.941176%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:8.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:13.882353%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.117647%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.411765%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;"><a style="background-color:rgb(255,255,255, 0.0);color:#0000FF;font-family:Times New Roman;font-size:9pt;font-weight:400;line-height:100%;text-decoration: underline;-sec-extract:exhibit;" href="lgnd123118exhibit321-n.htm">32.1</a></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Certifications by Principal Executive Officer and Principal Financial Officer, Pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">X&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.INS&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Instance Document.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.SCH&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Taxonomy Extension Schema Document.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.CAL&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Taxonomy Extension Calculation Linkbase Document.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.DEF&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Taxonomy Extension Definition Linkbase Document.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.LAB&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Taxonomy Extension Label Linkbase Document&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">101.PRE&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">XBRL Taxonomy Extension Presentation Linkbase Document.&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div><span><br/></span></div><div style="text-indent:-72pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8224;&#160;Confidential treatment has been requested for portions of this exhibit. These portions have been omitted and submitted separately to the Securities and Exchange Commission.</span></div><div style="text-indent:-72pt;padding-left:72pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">#&#160;Indicates management contract or compensatory plan.</span></div><div style="padding-left:72pt;"><span><br/></span></div><div style="padding-left:72pt;"><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div id="i_0_702"></div><div><span><br/></span></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:46.198830%;"><tr><td style="width:1.0%;"></td><td style="width:27.430380%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:68.569620%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Item 16.</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Form 10-K Summary</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None</span></div><div id="i_0_666"></div><div style="text-align:center;"><span><br/></span></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">91</span></div></div></div><hr style="page-break-after:always"></hr><div style="height:42.75pt;width:100%;"><div><span><br/></span></div></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">SIGNATURES</span></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Pursuant to the requirements of Section&#160;13 or 15(d) of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.</span></div><div><span><br/></span></div><div style="text-align:right;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:61.695906%;"><tr><td style="width:1.0%;"></td><td style="width:10.796209%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:85.203791%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="6" style="padding-top:2px;padding-bottom:2px;height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">LIGAND&#160;PHARMACEUTICALS&#160;INCORPORATED</span></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">By:</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">/</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">S</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">/&#160;&#160;&#160;&#160;J</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">OHN</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"> L. H</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">IGGINS&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">John L. Higgins,</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Chief Executive Officer</span></td></tr></table></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Date: February&#160;28, 2019&#160;</span></div><div style="text-indent:24pt;margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the registrant and in the capacities and on the dates indicated.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"></td><td style="width:37.353891%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:39.850220%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:0.534214%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:15.327460%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);text-decoration: underline;">Signature</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);text-decoration: underline;">Title</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);text-decoration: underline;">Date</span></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">/s/&#160;&#160;&#160;&#160;J</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">OHN</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"> L. H</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:400;line-height:100%;">IGGINS</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Chief Executive Officer and Director (Principal Executive Officer)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">John L. Higgins</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160; MATTHEW KORENBERG</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Executive Vice President, Finance and Chief Financial Officer (Principal Financial and Accounting Officer)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Matthew Korenberg</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:4pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;TODD C. DAVIS</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Todd C. Davis</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;SUNIL PATEL</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sunil Patel</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;STEPHEN L. SABBA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Stephen L. Sabba</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;JOHN W. KOZARICH</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">John W. Kozarich</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;JOHN L. LAMATTINA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">John L. Lamattina</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;JASON M. ARYEH</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jason M. Aryeh</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:3pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">/s/&#160;&#160;&#160;&#160;NANCY R. GRAY</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Director</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" rowspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Nancy R. Gray</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td></tr></table></div><div><span><br/></span></div><div style="position:relative;width:100%;height:42.75pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:9pt;line-height:120%;">92</span></div></div></div></body></html>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.48
<SEQUENCE>2
<FILENAME>lgnd123118exhibit1048-.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:72pt;width:100%;"><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:115%;">Exhibit 10.48</font></div><div><font><br></font></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:115%;">***Text Omitted and Filed Separately with</font></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:115%;">the Securities and Exchange Commission.</font></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:115%;">Confidential Treatment Requested Under</font></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7pt;font-weight:700;line-height:115%;">17 C.F.R. Sections 200.80(b)(4) and 240.24b</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:8pt;font-weight:700;line-height:115%;">-2.</font></div></div><div style="padding-right:9pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">DEVELOPMENT FUNDING AND ROYALTIES AGREEMENT</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">THIS DEVELOPMENT FUNDING AND ROYALTIES AGREEMENT </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">(this &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Agreement</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#8221;) is made and entered into effective as of December 13, 2018 (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Effective Date</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#8221;) by and between </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS, INC.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, a Delaware company having a place of business at 3911 Sorrento Valley Boulevard, Suite 110, San Diego, California 92121, U.S.A., (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Ligand</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#8221;), and</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;"> PALVELLA THERAPEUTICS, INC.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, a Delaware company having a place of business at 125 Strafford Avenue, Suite #360, Wayne, PA 19087, and its Affiliates (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Palvella</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#8221;).  Palvella and Ligand may be referred to herein individually as a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#8221; or collectively as the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Parties</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">.&#8221;</font></div><div><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">RECITALS</font></div><div><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">WHEREAS</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, Ligand is engaged in the development and commercialization of pharmaceutical products&#59;   </font></div><div style="text-align:justify;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">WHEREAS</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, Palvella owns or otherwise controls certain intellectual property rights and regulatory filings relating to the compound designated as PTX-022 (as defined below), which is the subject of clinical development&#59;</font></div><div style="text-align:justify;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">WHEREAS</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, Ligand desires to contribute to the funding of the development of PTX-022 in exchange for the right to receive future payments based on the development and commercialization of PTX-022&#59; and</font></div><div style="text-align:justify;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">WHEREAS</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, Palvella would like to obtain such funding from Ligand for such development activities, and make such future payments to Ligand, as set forth in this Agreement below. </font></div><div><font><br></font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">NOW, THEREFORE</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, in consideration of the foregoing and of the mutual covenants herein contained, the Parties hereby agree as follows.</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="text-indent:18pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:232%;">ARTICLE 1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:232%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:232%;">DEFINITIONS</font></div><div style="text-indent:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">The terms in this Agreement with initial letters capitalized, whether used in the singular or the plural, will have the meaning set forth below or, if not listed below, the meaning designated in places throughout this Agreement.</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Accredited Investor</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:130%;">&#8221; has the meaning ascribed to such term in Rule 501 of Regulation D promulgated under the Securities Act.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Affiliate</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:130%;">&#8221; of a Person means any other Person that (directly or indirectly) is controlled by, controls or is under common control with such initial Person.  </font></div><div id="i_0_123"></div><div style="text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">CON</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">FIDENTIAL</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">For the </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">purposes of this definition, the term &#8220;control&#8221; (and, with correlative meanings, the terms &#8220;controlled by&#8221; and &#8220;under common control with&#8221;) as used with respect to a Person means&#58;  (a) direct or indirect ownership of more than fifty percent (50%) of the voting interest in the Person in question, or more than fifty percent (50%) interest in the income of the Person in question&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however, </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">that, if local law requires a minimum percentage of local ownership, control will be established by direct or indirect beneficial ownership of one hundred percent (100%) of the maximum ownership percentage that may, under such local law, be owned by foreign interests&#59; or (b) possession, directly or indirectly, of the power to direct or cause the direction of management or policies of the Person in question (whether through ownership of securities or other ownership interests, by contract, or otherwise).</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Applicable Law</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means all laws, statutes, ordinances, codes, rules, and regulations that have been enacted by a Governmental Authority and are in force as of the Effective Date or come into force during the Term, in each case to the extent that the same are applicable to the performance by a Party of its obligations, and&#47;or exercise of its rights, under this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Bankruptcy Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">means the occurrence of any of the following in respect of a Person&#58; (a) an admission in writing by such Person of its inability to pay its debts generally or a general assignment by such Person for the benefit of creditors&#59; (b) the filing of any petition or answer by such Person seeking to adjudicate itself as bankrupt or insolvent, or seeking for itself any liquidation, winding-up, reorganization, arrangement, adjustment, protection, relief or composition of such Person or its debts under any Applicable Law relating to bankruptcy, insolvency, receivership, winding-up, liquidation, reorganization, examination, relief of debtors or other similar Applicable Law now or hereafter in effect, or seeking, consenting to or acquiescing in the entry of an order for relief in any case under any such Applicable Law, or the appointment of or taking possession by a receiver, trustee, custodian, liquidator, examiner, assignee, sequestrator or other similar official for such Person or for any substantial part of its property&#59; (c) corporate or other entity action taken by such Person to authorize any of the actions set forth in clause (a) or clause (b) above&#59; (d) without the consent or acquiescence of such Person, the entering of an order for relief or approving a petition for relief or reorganization or any other petition seeking any reorganization, arrangement, composition, readjustment, liquidation, dissolution or other similar relief under any present or future bankruptcy, insolvency or similar Applicable Law, or the filing of any such petition against such Person, or, without the consent or acquiescence of such Person, the entering of an order appointing a trustee, custodian, receiver or liquidator of such Person or of all or any substantial part of the property of such Person, in each case where such petition or order shall remain unstayed or shall not have been stayed or dismissed within ninety (90) days from entry thereof&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that in the case of an involuntary petition, such Person has not challenged such petition within ninety (90) days thereof&#59; (e)&#160;the appointment of a trustee, receiver, or custodian for all or substantially all of the property of such Person, or for any lesser portion </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">of such property, if the result materially and adversely affects the ability of such Person to fulfill its obligations hereunder, which appointment is not dismissed within sixty (60) days&#59; or (f)&#160;the dissolution or liquidation of Palvella.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Business Day</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any day that is not a Saturday, Sunday or other day on which commercial banks in New York City are authorized or required by Applicable Law to remain closed.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Calendar Quarter</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30 and December 31&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that (a) the</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">2</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> first Calendar Quarter of the Term will extend from the Effective Date to the end of the first complete Calendar Quarter thereafter, and (b) the last Calendar Quarter of the Term will end upon the expiration or termination of this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.7</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Calendar Year</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means (a) for the first Calendar Year of the Term, the period beginning on the Effective Date and ending on December 31, 2018, (b) for each Calendar Year of the Term thereafter, each successive period beginning on January 1 and ending twelve (12) consecutive calendar months later on December 31, and (c) for the last Calendar Year of the Term, the period beginning on January 1 of the Calendar Year in which this Agreement expires or terminates and ending on the effective date of expiration or termination of this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.8</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Change of Control</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means with respect to a Party&#58; (a) the sale or exclusive license of all or substantially all of such Party&#8217;s assets or business relating to this Agreement to a Third Party&#59; (b) a merger, reorganization or consolidation involving the Party and a Third Party in which the voting securities of the Party outstanding immediately prior thereto cease to represent at least fifty percent (50%) of the combined voting power of the surviving entity immediately after such merger, reorganization or consolidation&#59; or (c) a transaction (which may include a tender offer for such Party&#8217;s stock or the issuance, sale or exchange of stock of such Party) with a Third Party or Third Parties in which the stockholders of such Party immediately prior to the transaction do not, immediately after consummation of such transaction, (i) own, directly or indirectly through one or more intermediaries, stock or other securities of such Party that possess a majority of the voting power of all of such Party&#8217;s outstanding stock and other securities or (ii) possess the power to elect a majority of the members of such Party&#8217;s board of directors&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that, notwithstanding subsections (a), (b), and (c) above, a bona fide debt or equity financing of Palvella, including without limitation an IPO, Qualified Financing Event, Qualified Licensing Event or any equity financing involving a private placement of Palvella&#8217;s securities, will not constitute a Change of Control.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Claims</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 8.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.10</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Commercially Reasonable Efforts</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">means, as to Palvella and a Product, the level of effort, expertise, and resources required to Develop and Commercialize a Product consistent with the reasonable efforts that would be typically exerted by a biotechnology or pharmaceutical company of comparable size and capabilities as Palvella in pursuing the development and commercialization of a similar product with similar product characteristics at a similar stage in its development or product life, including without limitation with respect to commercial potential, the proprietary position of the Product, the regulatory status and approval process and other relevant technical, scientific, medical or legal factors. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.11</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Commercialize</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">,&#8221; &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Commercializing</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">,&#8221; and &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Commercialization</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means activities directed to manufacturing, obtaining pricing and reimbursement approvals for, marketing, promoting, distributing, importing, and&#47;or selling a Product.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Confidential Information</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any and all technical, business or other information or materials that are deemed confidential or proprietary to or by a Party and are disclosed or provided by such Party to the other Party under or in connection with this Agreement, whether disclosed or provided in oral, written, graphic, or electronic form, which may include without limitation trade secrets, processes, formulae, data, Know-How, improvements, inventions, chemical or biological materials, chemical</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">3</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> structures, techniques, clinical, sublicensing and marketing and other Development and&#47;or Commercialization plans, strategies, customer lists, financial data, intellectual property information, tangible or intangible proprietary information or materials or other information in whatever form.    </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">13</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Control</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; or &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Controlled</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means, with respect to an item, information, or an intellectual property right, that the applicable Party owns or has a license or other appropriate rights in, to, and under such item, information, or intellectual property right and has the ability to disclose and grant a license or sublicense to the other Party as provided for in this Agreement in, to, and under such item, information, or intellectual property right without violating the terms of any written agreement with any Third Party.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">14</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Cover</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">,&#8221; &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Covered</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">,&#8221; or &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Covering</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means, with respect to a Patent Right, that, in the absence of ownership of or a license under such Patent Right, the manufacture, use, offer for sale, sale or importation of such Product or components thereof would infringe a Valid Claim in such Patent Right.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">15</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means non-clinical, pre-clinical and clinical drug discovery, research, and&#47;or development activities, including without limitation quality assurance and quality control development, and any other activities reasonably related to or leading to the development and submission of information to a Regulatory Authority.  When used as a verb, &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Develop</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means to engage in Development.    </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">16</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development Budget</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 2.2.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">17</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development Plan</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 2.2.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">18</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Disclosing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 5.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Dollars</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; or &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">US$</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the lawful currency of the United States.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">20</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Enforcing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 6.2.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">21</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Export Control Laws</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means all applicable U.S., European Union or other applicable laws and regulations relating to (a) sanctions and embargoes imposed by the Office of Foreign Assets Control of the U.S. Department of the Treasury or the European Union or (b) the export or re-export of commodities, technologies or services or data, including without limitation the Export Administration Act of 1979, 24 U.S.C. &#167;&#167; 2401-2420&#59; the International Emergency Economic Powers Act, 50 U.S.C. &#167;&#167; 1701-1706&#59; the Trading with the Enemy Act, 50 U.S.C. App. &#167;&#167; 1 et. seq.&#59; the Arms Export Control Act, 22 U.S.C. &#167;&#167; 2778 and 2779&#59; and the International Boycott Provisions of Section 999 of the U.S. Internal Revenue Code of 1986, and European Union laws and regulations (including without limitation Regulation (EC) No 428&#47;2009, as amended), in each case as amended.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">21</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">FCPA</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the U.S. Foreign Corrupt Practices Act (15 U.S.C. &#167; 78dd-1 et. seq.), as amended. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">22</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">FDA</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the United States Food and Drug Administration, or any successor agency thereto.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">24</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Field</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the treatment of any and all indications, including without limitation pachyonychia congenita (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">PC</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;).</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">25</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">First Commercial Sale</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means, with respect to a particular Product, the first commercial sale for monetary value by Palvella, one or more of its Affiliates or one or more of its Licensees in an</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">4</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> arm&#8217;s length transaction to a Third Party that is not a Licensee, including without limitation any final sale to a distributor or wholesaler under any non-conditional sale arrangement, of such Product in the Field in the Territory after Regulatory Approval of such Product has been granted in the Field in the Territory. For the avoidance of doubt, sales or transfers of a Product for clinical and non-clinical research and trials (including studies reasonably necessary to comply with Applicable Law or requests by a Regulatory Authority), early access programs or for compassionate or similar use, shall not be considered a First Commercial Sale.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">26</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">GAAP</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means generally accepted accounting principles in the United States, consistently applied.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">27</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Governmental Authority</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">will mean any supranational, federal, national, multinational, regional, provincial, county, city, state, or local government, court, governmental agency, authority, board, bureau, instrumentality, regulatory body, or other political subdivision, domestic or foreign.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">28</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Indemnitee</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 8.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">29</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Initiate</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means, when used with respect to a Phase 2&#47;3 Clinical Study, the dosing of the first human patient with the first dose in such Phase 2&#47;3 Clinical Study. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">30</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">IPO</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means a transaction pursuant to which Palvella&#8217;s stock becomes publicly traded, including without limitation through a merger with a company whose stock is publicly traded or a firm commitment underwritten public offering of common stock of Palvella registered under the Securities Act.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">31</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Know-How</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means technical information and materials, including without limitation technology, software, instrumentation, devices, data, biological materials, assays, constructs, compounds, inventions (patentable or otherwise), practices, methods, algorithms, models, knowledge, know&#8209;how, trade secrets, skill and experience (including without limitation all biological, chemical, pharmacological, toxicological, clinical, assay and related know-how and trade secrets, and all manufacturing data, manufacturing processes, specifications, assays, quality control and testing procedures, regulatory submissions and related know</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">-</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">how</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">and</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">trade secrets). </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">32</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Knowledge</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the actual knowledge of &#91;***&#93;, after reasonable due inquiry, but is not meant to require or imply that any type of search (independent of that performed by the actual Governmental Authority during the normal course of patent prosecution, as applicable in a jurisdiction) has been conducted or opinion of counsel obtained.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">______</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">_________________________</font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">5</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">33</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">License</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">means any agreement pursuant to which Palvella grants to a Third Party (a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Licensee</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) a license, sublicense, or other right to any Palvella Patents or Regulatory Filings or Regulatory Approvals relating to the Products&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that a License shall not include (a) any agreement pursuant to which a Licensee obtains solely the right to distribute a Product after purchase from Palvella, or (b) any agreement pursuant to which Palvella or any of its Affiliates grants a license or sublicense of any of its intellectual property rights (i) solely to conduct research, (ii) solely to manufacture a Product, or (iii) otherwise to service providers solely on a non-exclusive basis in the ordinary course of Development or Commercialization of a Product (e.g., material transfer agreements, distribution agreements, and consulting agreements). </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">.34</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Licensee</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in the definition of License. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">35</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Losses</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 8.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Milestone Payment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 4.2.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">37</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">NDA</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means a New Drug Application filed with the FDA that is required for approval for the applicable Product in the United States, or its foreign equivalent in the Territory.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">38</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Net Sales</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means, with respect to any Product, the gross amounts received</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">by Palvella, its Affiliates and Licensees for arm&#8217;s length sales of such Product in the Field in the Territory to a Third Party (excluding any sales among Palvella, its Affiliates and any Licensee), commencing with the First Commercial Sale, less the following deductions solely to the extent incurred or allowed with respect to such sales, and solely to the extent such deductions are in accordance with GAAP, and which are not already reflected as a deduction from the invoiced price&#58;  (a) discounts (to the extent not previously applied to such amounts received), charge-back payments, and rebates&#59; (b) credits or allowances for damaged goods, rejections, recalls or returns of such Product&#59; (c) freight, insurance, postage, and shipping charges for delivery of such Product, to the extent separately billed on the invoice&#59; (d) taxes, customs, or duties levied on, absorbed, or otherwise imposed on the sale of such Product, as adjusted for rebates and refunds, to the extent not paid by the Third Party and only to the extent such taxes, customs, or duties are not reimbursed to the paying party, but excluding all income taxes&#59; and (e) that portion of the annual fees due under Section 9008 of the United States Patient Protection and Affordable Care Act of 2010 (Pub. L. No. 111-48) and any other fees imposed by any Applicable Law.  If a Product is sold by Palvella, its Affiliates or Licensees through intermediaries such as agents, consignees or co-promoters who do not purchase and take title to Product, Royalties will be due only on sales to those Third Parties who actually purchase and take title to Product through such intermediaries.  Net Sales will be determined in accordance with GAAP.</font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">With respect to sales of a Product invoiced in Dollars, Net Sales shall be determined in Dollars. With respect to sales of a Product invoiced in a currency other than Dollars, Net Sales shall be determined by converting the currencies at which the sales are made into Dollars, at rates of exchange determined in a manner consistent with Palvella&#8217;s or the applicable Licensee&#8217;s methods for calculating rates of exchange in the preparation of Palvella&#8217;s or such applicable Licensee&#8217;s annual financial statements in accordance with GAAP.</font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">A Product transferred to Third Parties in connection with clinical and non-clinical research and trials (including studies reasonably necessary to comply with Applicable Law), Product samples, charitable</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">6</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> purposes, promotional purposes, early access programs, compassionate sales or use, or an indigent program or similar </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">bona fide</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">arrangements for which Palvella or any of its Affiliates or Licensees for good faith business reasons receives consideration in respect thereof that is less than the average cost of goods for a Product shall not be included in Net Sales.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">39</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Non-Enforcing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 6.2.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">40</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Palvella Patents</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">means (a) any and all patents and patent applications that Cover a Product or its manufacture, use, sale, export or import, including without limitation the patents and patent applications set forth in Appendix B, and (b) any Patent Rights based on the patents and patent applications described in subsection (a).  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">41</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Patent Rights</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means (a) patents and patent applications, and any foreign counterparts thereof, (b) all divisionals, continuations, continuations-in-part of any of the foregoing, and any foreign counterparts thereof, and (c) all patents issuing on any of the foregoing, and any foreign counterparts thereof, together with all registrations, reissues, re&#8209;examinations, supplemental protection certificates, substitutions or extensions thereof, and any foreign counterparts thereof. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">42</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Person</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any natural person, firm, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, business trust, unincorporated organization, Governmental Authority or any other legal entity, including without limitation public bodies, whether acting in an individual, fiduciary or other capacity</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">43</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Phase 2&#47;3 Clinical Study</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means a human clinical study of a Product in any country on a sufficient number of subjects that is designed to establish that such Product is safe and efficacious for its intended use, and to determine warnings, precautions, and adverse reactions that are associated with such Product in the dosage range to be prescribed, which trial is intended to support Regulatory Approval of such Product, as described in 21 C.F.R. &#167; 312.21(c), or equivalent clinical study in a country other than the United States.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">44</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Prior CDA</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the Mutual Confidentiality Agreement between the Parties, effective as of September 25, 2018.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">45</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Product</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any product that contains PTX-022. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">46</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">PTO</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the United States Patent and Trademark Office.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">47</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">PTX-022</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the compound set forth on Appendix A.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">48</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Public Official or Entity</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means (a) any officer, employee (including without limitation physicians, hospital administrators or other healthcare professionals), agent, representative, department, agency, de facto official, representative, corporate entity, instrumentality or subdivision of any government, military or international organization, including without limitation any ministry or department of health or any state-owned or affiliated company or hospital, or (b) any candidate for political office, any political party or any official of a political party.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">7</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">49</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Qualified Financing Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means an IPO or one or more equity financings of Palvella pursuant to which the gross proceeds in the aggregate to Palvella are at least &#91;***&#93;.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">50</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Qualified Licensing Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the date on which Palvella receives an aggregate of &#91;***&#93; in license fees pursuant to one or more Licenses&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">that any amounts received by Palvella under such Licenses that are bona fide reimbursements for expenses incurred by Palvella in the Development of PTX-022 will not be included in such license fees for purposes of this definition.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">51</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Receiving Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 5.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">52</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Approval</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means approval of an NDA by the FDA for the applicable Product in the United States, or approval by the applicable Regulatory Authority of a regulatory approval application that is equivalent to an NDA in a country other than the United States, and any approvals, licenses, registrations, or authorizations necessary for the manufacture, marketing, and sale of Product in such country and, where relevant, including without limitation any reimbursement or pricing approvals. For the sake of clarity, except as otherwise expressly provided herein, &#8220;Regulatory Approval&#8221; will not be achieved for a Product in a country or, where applicable, a multinational jurisdiction until any applicable approvals relating to pricing and reimbursement from the relevant Regulatory Authorities have been obtained in such country or such jurisdiction.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">53</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Authority</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any national or supranational Governmental Authority, including without limitation FDA, that has responsibility for granting any licenses or approvals or granting pricing and&#47;or reimbursement approvals necessary for the development, marketing, and sale of a Product in any country.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">54</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Exclusivity</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any exclusive marketing rights or data exclusivity rights conferred by any Governmental Authority under Applicable Law with respect to a Product in a country or jurisdiction in the Territory to prevent Third Parties from Commercializing such Product in such country or jurisdiction, other than a Patent Right, including without limitation orphan drug exclusivity, pediatric exclusivity, rights conferred in the U.S. under the Hatch-Waxman Act or the FDA Modernization Act of 1997, in the EU under Directive 2001&#47;83&#47;EC, or rights similar thereto in other countries or regulatory jurisdictions in the Territory.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">55</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Filings</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any and all regulatory applications, filings, modifications, amendments, supplements, revisions, reports, submissions, authorizations, and Regulatory Approvals, and associated correspondence required to Develop and Commercialize Products in the Territory, including without limitation any reports or amendments necessary to maintain Regulatory Approvals.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">56</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalties</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 4.3.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">57</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Term</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 4.3.2.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">58</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Securities Act</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the Securities Act of 1933, as amended.</font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">___________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">8</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">59</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Term</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 7.1. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">60</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Territory</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means worldwide.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">61</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Third Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means any Person other than Palvella, Ligand, and their respective Affiliates.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">62</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">United States</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; or</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">U.S.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; means the United States of America and all of its territories and possessions.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">63</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Upfront Payment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221; has the meaning set forth in Section 4.1.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">1.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">64</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Valid Claim</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;  means either (a) a claim of an issued and unexpired patent or a supplementary protection certificate</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">within the Palvella Patents that has not been held permanently revoked, unenforceable, or invalid by a decision of a court or other Governmental Authority of competent jurisdiction, unappealable or unappealed within the time allowed for appeal and that is not admitted to be invalid or unenforceable through reissue, disclaimer, or otherwise (i.e., only to the extent the subject matter is disclaimed or is sought to be deleted or amended through reissue), or (b) a claim of a pending patent application within the Palvella Patents that has not been abandoned, finally rejected, or expired without the possibility of appeal or refilling.  </font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">PALVELLA RESPONSIBILITIES&#59; LICENSING&#59; REPORTING</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Responsibilities</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will have the sole right, as between the Parties, to Develop and Commercialize Products in the Field, including without limitation determining the marketing and regulatory strategies for seeking (if and when appropriate) Regulatory Approvals and Regulatory Exclusivity in the Territory for Products in the Field, filing for such Regulatory Approvals and Regulatory Exclusivity for Products in the Field in the Territory, preparing, submitting, and maintaining any and all Regulatory Filings and Regulatory Approvals for Products in the Field in the Territory, and seeking any necessary Regulatory Approvals of Regulatory Authorities for Product labeling and promotional materials to be used in the applicable jurisdiction(s) in connection with Commercializing Products in the Field in the Territory.  As between the Parties, Palvella will be responsible for all costs and expenses incurred by Palvella in connection with the foregoing activities, except for the payment set forth in Section 4.1.  If an Affiliate and&#47;or a Licensee meets or fulfills any or all of the obligations of Palvella under this Agreement, and&#47;or observes any of the terms or conditions hereof, then Palvella will be deemed to have met or fulfilled such obligations or observed such terms or conditions, as the case may be.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">9</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development Plan and Development Budget</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Palvella will conduct the activities set forth in the Development plan set forth on Appendix C (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development Plan</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) in accordance with the Development budget set forth on Appendix D (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Development Budget</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;).  Palvella may update or modify in good faith the Development Plan and the Development Budget from time to time in its sole discretion without Ligand&#8217;s consent, </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that such amendments or modifications relate to reasonable and customary Development activities and do not result, in the aggregate, in additional expenditures in excess of &#91;***&#93; of, or result in a reduction in expenditures by more than &#91;***&#93; of, the aggregate amount of expenditures set forth in the Development Budget set forth on Appendix D as of the Effective Date. Otherwise, Palvella must obtain Ligand&#8217;s consent before amending or modifying the Development Budget, with such consent not to be unreasonably withheld, delayed, or conditioned.  Palvella will use the Upfront Payment solely to fund activities in accordance with the Development Plan and the Development Budget, each of which may be amended from time to time in accordance with this Section 2.2.  Without limiting any other remedies available, if all Development of Product(s) in the Field in the Territory is ceased, Palvella will pay to Ligand an amount equal to &#91;***&#93;.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Diligence.  </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will use Commercially Reasonable Efforts to carry out its responsibilities under this Agreement.  During the Term, Palvella will use Commercially Reasonable Efforts to Develop and Commercialize at least one (1) Product in the Field in the Territory.  Without limiting the foregoing, Palvella will  Initiate a Phase 2&#47;3 Clinical Study by December 31, 2019.  Palvella will deliver to Ligand within thirty (30) days after the end of each Calendar Year a written report summarizing in reasonable detail the efforts of Palvella in the prior year to meet its obligations to Develop and Commercialize Products consistent with this Section 2.3 and the planned Development and Commercialization activities to be conducted by Palvella in the current Calendar Year.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Licensing</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.4.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Right to License.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">  Palvella will retain the right to perform its activities under this Agreement through Licensees, subject to this Section 2.4.  Palvella will remain responsible for the performance of Licensees under this Agreement, including without limitation for all payments due hereunder.  Palvella will provide Ligand with notice of the entering into of each License promptly after execution of such License.  In addition, Palvella will provide a redacted copy of any such License to Ligand after execution of such License.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.4.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Terms</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Each License granted by Palvella pursuant to Section 2.4.1 will be subject to the terms and conditions of this Agreement and will contain terms and conditions consistent in all material respects with those in this Agreement.  Agreements with any Licensee that include the right to Commercialize any Product(s) will contain provisions requiring such Licensee to calculate and report on net sales in sufficient detail to permit Palvella to meet its obligations set forth in Sections 4.4 and 4.5, and, to the extent that such Licensee will have access to Ligand&#8217;s Confidential Information, a requirement that such Licensee comply with confidentiality and non-use provisions consistent in all material respects with those contained in Article 5 with respect to Ligand&#8217;s Confidential Information.</font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">___________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">10</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2.4.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Subcontracting</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Palvella may utilize the services of Third Parties, including without limitation</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Third Party contract research organizations, contract manufacturing organizations, suppliers and service providers to perform its Development and Commercialization activities&#59; provided that Palvella will remain at all times fully liable for its respective responsibilities under this Agreement.  Any agreement with a Third Party to perform Palvella&#8217;s responsibilities under this Agreement will include confidentiality and non-use provisions which are no less stringent than those set forth in Article 5 and intellectual property provisions that will allow Palvella to comply with Article 6.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">REGULATORY </font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Filings.  </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will solely own and control any and all Regulatory Approvals and any and all other Regulatory Filings submitted in connection with seeking and maintaining Regulatory Approvals for Products in the Field in the Territory.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Regulatory Communications</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Palvella will be the sole contact, as between the Parties, with the applicable Regulatory Authorities and will be solely responsible, using Commercially Reasonable Efforts, for all communications with such Regulatory Authorities that relate to any Regulatory Approvals or other Regulatory Filings prior to and after any Regulatory Approval with respect to the Products in the Field in the Territory.  Except as may be required by Applicable Law, Ligand will not communicate regarding Products in the Field with any Governmental Authority having jurisdiction in the Territory unless explicitly requested or permitted in writing to do so by Palvella or unless so ordered by such Governmental Authority in the Territory, in which case Ligand will provide to Palvella notice of such order as soon as practicable, but in no event later than five (5) business days after receipt of such order.  If Ligand is required to respond to any requests from or by any and all Regulatory Authorities with respect to any Product, Palvella will have an opportunity to comment on the response to the extent such response may materially impact the Product before Ligand submits such response and Ligand will provide a copy of the final response to Palvella.   </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Reports.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.3.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Within thirty (30) days after the end of each Calendar Quarter during the Term, Palvella will deliver to Ligand a report containing information regarding its Development and Commercialization activities conducted by or on behalf of Palvella and its Affiliates and Licensees during such Calendar Quarter.  Without limiting the foregoing, such report shall include a description of all material activities in connection with any Regulatory Approvals and Regulatory Exclusivity for Products in the Field in the Territory, preparing, submitting, and maintaining any and all Regulatory Filings and Regulatory Approvals for Products in the Field in the Territory, and seeking any necessary Regulatory Approvals of Regulatory Authorities for Product labeling and promotional materials to be used in the applicable jurisdiction(s) in connection with Commercializing Products in the Field. In addition, such reports shall contain a description of Palvella&#8217;s performance against the activities and timelines set forth in the Development Plan and costs and expenses incurred against the Development Budget, each of which may be amended from time to time in accordance with Section 2.2. </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">11</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.3.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Prior to the consummation of an IPO, Palvella shall deliver to Ligand the following financial statements&#58;</font></div><div style="text-indent:108pt;text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(a)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">within thirty (30) days after the end of each of the first three (3) Calendar Quarters of a Calendar Year, copies of the unaudited financial statements of Palvella for such Calendar Quarter&#59; and </font></div><div style="text-indent:108pt;text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(b)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">within one hundred eighty (180) days after the end of each Calendar Year, copies of the audited financial statements of Palvella for such Calendar Year.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3.3.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Prior to the consummation of an IPO, Palvella will provide Ligand with written notice at such time as (a) Palvella becomes insolvent as defined in Applicable Law, including without limitation interpretations in applicable case law&#59; (b) Palvella is unable to pay its debts as they become due&#59; (c) Palvella suspends, closes, or otherwise ceases to operate a portion of its business having a material adverse effect on Palvella&#8217;s ability to comply with its material obligations under this Agreement&#59; and (d) Palvella fails to have enough cash on hand to fund at least two Calendar Quarters of its budgeted operating expenses, based on the Development Budget.  In addition, within fifteen (15) days of a written request of Ligand (such request not to be made more than one time during any Calendar Year), Palvella will provide Ligand with its most recent audited financial statements.  Ligand shall, and shall cause its representatives and Affiliates to, treat all notices and financial reports (and the information contained therein) as Confidential Information of Palvella, subject to the terms of Article 5.</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">PAYMENTS</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Upfront Payment.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">  In consideration for the rights granted under this Agreement to Ligand, including without limitation the right to receive the payments set forth in Sections 4.2 and 4.3, and to fund the Development activities described in this Agreement, Ligand shall pay Palvella a one-time payment of Ten Million Dollars ($10,000,000) (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Upfront Payment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) on the Effective Date to an account designated in writing by Palvella.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Milestone Payments</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  In consideration for the Upfront Payment paid to Palvella under Section 4.1, Palvella will pay Ligand each milestone payment set forth in the table below after the first achievement of the specified milestone event (each, a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Milestone Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) by Palvella, its Licensees or their Affiliates for a Product (each, a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Milestone Payment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;).  All such payments are non-refundable and non-creditable.  Palvella will notify Ligand of any such achievement within five (5) business days after such achievement.  Ligand may submit an invoice to Palvella for each Milestone Payment set forth in the table in this Section 4.2 below at any time after the corresponding Milestone Event is achieved.  Palvella will pay any amounts payable under this Section 4.2 within thirty (30) days after receipt of an invoice therefor&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that such invoice is submitted after the date on which such Milestone Payment becomes payable. If Ligand does not submit an invoice to Palvella with respect to the Milestone Payment, then such Milestone Payment will be payable within thirty (30) days after the date set forth in Palvella&#8217;s notice under this Section 4.2.  For the avoidance of doubt, each Milestone Payment is payable a maximum of one time only, regardless of the number of times a Milestone Event is achieved. </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">12</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="padding-left:32pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:76.169591%;"><tr><td style="width:1.0%;"></td><td style="width:74.967370%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.032630%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;text-decoration: underline;">Milestone Event</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:100%;text-decoration: underline;">Milestone Payment</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">&#91;***&#93;</font></div></td></tr></table></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Payments</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.3.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalties on Products</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font></div><div style="text-indent:108pt;text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(a)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">In partial consideration for the Upfront Payment paid to Palvella under Section 4.1, Palvella hereby sells to Ligand all of its right, title, and interest in and to royalties on aggregate annual Net Sales of all Products in the Territory, as calculated by multiplying the applicable royalty rate in the table below (as may be adjusted pursuant to Section 4.3.1(a)(ii)) by the corresponding amount of incremental Net Sales of all Products in the Territory in each Calendar Year (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalties</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;).  Palvella shall have no right, title, or interest in the Royalties and Palvella shall remit all Royalties to Ligand in accordance with Section 4.4. Commencing on the date that the Royalties paid to Ligand under this Section 4.3 and the payments paid to Ligand under Section 4.2 cumulatively equal at least &#91;***&#93; (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Buy-Down Date</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;), Palvella will have the right to reduce the royalty rates set forth in Section 4.3.1(a)(i) by making a payment or payments (each, a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Buy-Down Payment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) at any time during the Term after the Royalty Buy-Down Date, as set forth in Section 4.3.1(a)(ii).</font></div><div style="text-indent:144pt;text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(i)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If Palvella has not made a Royalty Buy-Down Payment within the time period set forth in Section 4.3.1(a), above, the royalty rates for the Term shall be as follows&#58; </font></div><div style="padding-left:36pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:82.456140%;"><tr><td style="width:1.0%;"></td><td style="width:74.595745%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.404255%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Net Sales Tier</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Royalty Rate</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are less than or equal to &#91;***&#93;</font></div><div style="padding-left:5pt;padding-right:5pt;"><font><br></font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;but less than or equal to &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr></table></div><div style="text-indent:36pt;margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">For example, and without limitation, if aggregate annual Net Sales of all Products in the Field in the Territory in a Calendar Year is </font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:130%;vertical-align:top;">&#91;***&#93;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, then Royalties due by Palvella would equal &#91;***&#93;.</font></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">___________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:144pt;text-align:justify;margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">13</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:144pt;text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(ii)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Buy-Down</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  At any time on or after the Royalty Buy-Down Date, Palvella shall have the right to reduce, in accordance with Section 4.3.1(a)(ii)(A), (B), (C), and&#47;or (D), the royalty rates set forth in Section 4.3.1(a)(i).  For clarity, Palvella will have the right to elect the options set forth in one or more of Section 4.3.1(a)(ii)(A), (B), (C), or (D).  For example, and without limitation, Palvella may elect the option set forth in Section 4.3.1(a)(ii)(A) by making the &#91;***&#93; payment set forth therein, and then at a later time elect the option set forth in Section 4.3.1(a)(ii)(C) by making a payment equal to (x) &#91;***&#93; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">less</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> (y) &#91;***&#93; previously paid pursuant to Section 4.3.1(a)(ii)(A).</font></div><div style="text-indent:184.5pt;padding-left:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(A)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If Palvella has made a Royalty Buy-Down Payment of &#91;***&#93; within the time period set forth in Section 4.3.1(a), above, the royalty rates applicable commencing in the first Calendar Quarter after receipt of such Royalty Buy-Down Payment shall be as follows&#58; </font></div><div style="padding-left:36pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:82.456140%;"><tr><td style="width:1.0%;"></td><td style="width:74.595745%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.404255%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Net Sales Tier</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Royalty Rate</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are less than or equal to &#91;***&#93;</font></div><div style="padding-left:5pt;padding-right:5pt;"><font><br></font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93; but less than or equal to &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr></table></div><div><font><br></font></div><div style="text-indent:180pt;padding-left:36pt;text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">(B)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">If Palvella has made Royalty Buy-Down Payment(s) totaling &#91;***&#93; within the time period set forth in Section 4.3.1(a), above, the royalty rates applicable commencing in the first Calendar Quarter after receipt of such Royalty Buy-Down Payment(s) totaling &#91;***&#93; shall be as follows&#58; </font></div><div style="padding-left:36pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:82.456140%;"><tr><td style="width:1.0%;"></td><td style="width:74.595745%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.404255%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Net Sales Tier</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Royalty Rate</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are less than or equal to &#91;***&#93;</font></div><div style="padding-left:5pt;padding-right:5pt;"><font><br></font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than </font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;font-weight:400;line-height:120%;vertical-align:top;">&#91;***&#93;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">but less than or equal to &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr></table></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">___________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:180pt;padding-left:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">14</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:180pt;padding-left:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(C)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If Palvella has made Royalty Buy-Down Payment(s) totaling &#91;***&#93; within the time period set forth in Section 4.3.1(a), above, the royalty rates applicable commencing in the first Calendar Quarter after receipt of such Royalty Buy-Down Payment(s) totaling &#91;***&#93; shall be as follows&#58; </font></div><div style="padding-left:36pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:82.456140%;"><tr><td style="width:1.0%;"></td><td style="width:74.595745%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.404255%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Net Sales Tier</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Royalty Rate</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are less than or equal to &#91;***&#93;</font></div><div style="padding-left:5pt;padding-right:5pt;"><font><br></font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="height:17pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td></tr></table></div><div style="text-indent:180pt;padding-left:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">(D)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If Palvella has made Royalty Buy-Down Payment(s) totaling &#91;***&#93; within the time period set forth in Section 4.3.1(a), above, the royalty rates applicable commencing in the first Calendar Quarter after receipt of such Royalty Buy-Down Payment(s) totaling &#91;***&#93; shall be as follows&#58; </font></div><div style="padding-left:36pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:82.456140%;"><tr><td style="width:1.0%;"></td><td style="width:74.595745%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.404255%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Net Sales Tier</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:700;line-height:120%;">Royalty Rate</font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;margin-top:3pt;"><font><br></font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are less than or equal to &#91;***&#93;</font></div><div style="padding-left:5pt;padding-right:5pt;"><font><br></font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:100%;">For that portion of annual aggregate Net Sales of Products in a Calendar Year that are greater than &#91;***&#93;</font></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font><br></font></div><div style="padding-left:5pt;padding-right:5pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:11pt;font-weight:400;line-height:120%;">&#91;***&#93;</font></div></td></tr></table></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.3.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Term.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">  Royalties will be remitted under this Section 4.3, on a country-by-country basis, commencing on First Commercial Sale of such Product in such country until the last to occur of&#58;  &#91;***&#93; (the </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#8220;Royalty Term&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">).  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Royalty Reports and Payments</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  During the Term following the First Commercial Sale of any Product, within forty-five (45) days after the end of each of the first three (3) Calendar Quarters of each Calendar Year and within sixty (60) days after the end of the last Calendar Quarter of each Calendar Year, Palvella will pay to Ligand Royalties due for such Calendar Quarter calculated in accordance with Section 4.3 and will deliver to Ligand a Royalties report showing, on a country-by-country basis, the information set forth in this Section 4.4 below&#58;</font></div><div style="text-indent:36pt;margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font><br></font></div><div style="margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">___________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">15</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.4.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">the gross amount invoiced for and the amounts received and the Net Sales resulting from sales of Products sold by Palvella, its Affiliates or Licensees during such Calendar Quarter, including without limitation the specific deductions applied in the calculation of such Net Sales amounts, and any amounts required to be included in Net Sales pursuant to Section 6.2.3&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.4.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">the Royalties (in Dollars) that have accrued in such Calendar Quarter with respect to such Net Sales&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.4.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">withholding taxes, if any, required by Applicable Law to be deducted with respect to such Royalties&#59; and</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.4.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">the rate of exchange used by Palvella in determining the amount of Dollars due hereunder.</font></div><div style="text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">If no Royalties are due for any Calendar Quarter hereunder, Palvella will so report.  Palvella will keep, and will require in its Licenses, and use good faith efforts to enforce such requirements, its Licensees and their respective Affiliates to keep (all in accordance with GAAP), complete and accurate records in sufficient detail to properly reflect the Net Sales to enable the Royalties due hereunder to be determined for a period of at least three (3) Calendar Years.</font></div><div style="text-align:justify;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">In addition, Palvella will deliver to Ligand no later than twenty-five (25) days following the end of each Calendar Quarter a preliminary statement setting forth the actual Net Sales for the first two (2) months of such Calendar Quarter and estimated Net Sales for the third (3rd) month of such Calendar Quarter, the calculation of Royalties or Net Sales due on a country-by-country basis (based on such actual and estimated Net Sales) and, if applicable, the exchange rate to be utilized by Palvella to convert a local currency payment to Dollars.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Audits of Royalty Reports</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Upon the written request of Ligand and not more than once in each Calendar Year, Palvella will permit an independent certified public accounting firm selected by Ligand and reasonably acceptable to Palvella, at Ligand&#8217;s expense, to have access during normal business hours to such records of Palvella as may be necessary or reasonably useful to verify the accuracy of the payment reports made and the amounts owed to Ligand under this Agreement for any Calendar Year period ending not more than thirty-six (36) months prior to the date of such request.  Such rights with respect to any Calendar Year will terminate upon the earlier to occur of (a) the completion of an audit pursuant to this Section 4.5 with respect to such Calendar Year and (b) three (3) years after the end of any such Calendar Year.  Ligand will provide Palvella with a copy of such accounting firm&#8217;s written report within thirty (30) days after completion of such report.  If such accounting firm concludes that an overpayment or underpayment was made, then the owing Party will pay the amount due within thirty (30) days after the date Ligand delivers to Palvella such accounting firm&#8217;s written report so concluding, and any accrued interest as determined in accordance with Section 4.9 from the date such overpayment was paid or such underpayment was originally due, as applicable, until payment thereof.  Ligand will bear the full cost of such audit unless such audit discloses that the additional payment payable by Palvella for the audited period is more than five percent (5%) of the amount of the payments due for that audited period, in which case Palvella will pay the reasonable documented fees and expenses charged by the accounting firm.  If the Parties dispute any such accounting firm&#8217;s conclusion, they will resolve such issue pursuant to Article 11.  Ligand will treat all information subject to review under Section 4.5 in accordance with the confidentiality provisions of this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">16</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Currency of Payments</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  All payments under this Agreement will be made in Dollars by wire transfer of immediately available funds into an account designated by Ligand.  Net Sales outside of the U.S. will be first determined in the currency in which they are earned and will then be converted into an amount in Dollars using Palvella&#8217;s or the Licensee&#8217;s, as applicable, customary and usual conversion procedures used in preparing its financial statements pursuant to GAAP for the applicable reporting period. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.7</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Blocked Currency</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  In each country in the Territory where the local currency is blocked and cannot be removed from the country, at the election of Ligand, Royalties accrued on Net Sales in such country will be paid to Ligand in local currency by deposit in a local bank in such country designated by Ligand. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.8</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Taxes</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Each Party will be solely responsible for the payment of all taxes imposed on its share of income arising directly or indirectly from the efforts of the Parties under this Agreement.  The Parties agree to cooperate with one another and use reasonable efforts to reduce or eliminate tax withholding or similar obligations in respect of Royalties, Milestone Payments, and other payments made by Palvella to Ligand under this Agreement.  To the extent Palvella is required under the Internal Revenue Code of 1986, as amended (the </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#8220;Code&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">), or any other tax laws to deduct and withhold taxes on any payment to Ligand, and Palvella will pay the amounts of such taxes to the proper Governmental Authority in a timely manner and promptly transmit to Ligand an official tax certificate or other evidence of such withholding sufficient to enable Ligand to claim such payment of taxes.  Upon Palvella&#8217;s reasonable request, Ligand will provide Palvella any tax forms that may be reasonably necessary in order for Palvella to determine whether to withhold tax on any such payments or to withhold tax on such payments at a reduced rate under the Code or any other tax laws, including without limitation any applicable bilateral income tax treaty.  Palvella will give reasonable support so that any withholding tax or value added tax may be minimized or avoided to the extent permitted under the Applicable Laws and treaties.  Each Party will provide the other with reasonable assistance to enable the recovery, as permitted by Applicable Laws, of withholding taxes, value added taxes, or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding tax or value added tax.  Palvella will use commercially reasonable efforts to require its Licensees to cooperate with Palvella and Ligand in a manner consistent with this Section 4.8.  If any payment required to be made by Palvella under this Agreement is subject to increased deduction or withholding of tax by Ligand, then the sum payable by Palvella (in respect of which such increased deduction or withholding is required to be made) will be increased to the extent necessary to ensure that Ligand receives a sum equal to the sum which it would have received if no such increased tax deduction or withholding had been required.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4.9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Interest Due</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will pay Ligand interest on any payments that are not paid on or before the date such payments are due under this Agreement at a monthly interest rate equal to the U.S. prime interest rate, as reported by </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">The Wall Street Journal</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> (New York edition) for the first Business Day of the month in which such payment was due plus five percentage points (5 ppts), or the maximum applicable legal rate, if less, calculated based on the total number of days payment is delinquent. </font></div><div style="text-align:center;margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">17</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">NONDISCLOSURE OF CONFIDENTIAL INFORMATION</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Nondisclosure</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Each Party agrees that, during the Term and for a period of ten (10) years thereafter (or, for any trade secret, for so long as the Disclosing Party maintains such trade secret as a trade secret), a Party (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Receiving Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) receiving Confidential Information of the other Party (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Disclosing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) will (a) maintain in confidence such Confidential Information, (b) not disclose such Confidential Information to any Third Party without the prior written consent of the Disclosing Party, except for disclosures expressly permitted in this Article 5, and (c) not use such Confidential Information for any purpose except those expressly permitted by this Agreement.  The Parties agree that any Confidential Information (within the meaning of the Prior CDA) disclosed by the Parties or their Affiliates pursuant to the Prior CDA will be Confidential Information within the meaning of, and will be subject to, this Article 5.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Exceptions.  </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">The obligations under Section 5.1 will not apply with respect to any portion of Confidential Information of a Disclosing Party that the Receiving Party can show by competent evidence&#58;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">at the time of disclosure to Receiving Party is in the public domain&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.2.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">after disclosure, becomes part of the public domain by publication or otherwise, except by breach of this Agreement by the Receiving Party or anyone to whom the Receiving Party disclosed Confidential Information&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.2.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">was (a) in the Receiving Party&#8217;s possession at the time of disclosure without any obligation to keep it confidential or any restriction on its use or (b) subsequently and independently developed by the Receiving Party&#8217;s employees who had no knowledge of and who did not use, rely on or refer to any of Disclosing Party&#8217;s Confidential Information, in each case as shown by Receiving Party&#8217;s records&#59; or</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.2.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">is received by the Receiving Party from a Third Party who has the lawful right to disclose such Confidential Information and who has not obtained such Confidential Information either directly or indirectly from the Disclosing Party.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Authorized Disclosure</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  To the extent (and only to the extent) that it is reasonably necessary or appropriate to fulfill its obligations or exercise its rights under this Agreement, the Receiving Party may disclose Confidential Information belonging to the Disclosing Party in the following instances&#58;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.3.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">prosecuting or defending litigation&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.3.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">subject to Sections 5.4 and 5.5, required by Applicable Laws (including without limitation the rules and regulations of the U.S. Securities and Exchange Commission or any national securities exchange) and with judicial process&#59; and</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.3.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">to Affiliates in connection with the performance of this Agreement and solely on a need-to-know basis&#59; to potential or actual collaborators (including without limitation actual and potential</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">18</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> Licensees), who prior to disclosure must be bound by written obligations of confidentiality and non-use no less restrictive than the obligations set forth in this Article 5&#59; to potential or actual investment bankers, investors, lenders, acquirers, merger partners or other potential financial partners, and their attorneys and agents), who prior to disclosure must be bound by written obligations of confidentiality and non-use no less restrictive than the obligations set forth in this Article 5&#59; or employees, independent contractors (including without limitation contract research organizations, contract manufacturing organizations, consultants and clinical investigators) or agents, each of whom prior to disclosure must be bound by written obligations of confidentiality and non-use no less restrictive than the obligations set forth in this Article 5&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that the Receiving Party will remain responsible for any failure by any Person who receives Confidential Information pursuant to this Section 5.3.3 to treat such Confidential Information as required under this Article 5. </font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If and whenever any Confidential Information is disclosed in accordance with this Section 5.3, such disclosure will not cause any such information to cease to be Confidential Information except to the extent that such disclosure results in a public disclosure of such information (other than in breach of this Agreement).  Where reasonably possible and subject to Sections 5.4 and 5.5, the Receiving Party will notify the Disclosing Party in writing of the Receiving Party&#8217;s intent to make such disclosure pursuant to Sections 5.3.1&#8211;5.3.3 sufficiently prior to making such disclosure so as to allow the Disclosing Party adequate time to take whatever action appropriate to protect the confidentiality of the information while still permitting such disclosure, and the Receiving Party will cooperate with the Disclosing Party in such efforts.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Required Disclosure</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  A Receiving Party may disclose Confidential Information of the Disclosing Party to the extent such disclosure is required pursuant to interrogatories, judicial requests for information or documents, subpoena, civil investigative demand issued by a court or Governmental Authority or as otherwise required by Applicable Law&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that the Receiving Party will notify the Disclosing Party promptly in writing upon receipt thereof, giving (where practicable) the Disclosing Party sufficient advance notice to permit it to oppose, limit or seek a protective order or confidential treatment for such disclosure&#59; and </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, further</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that the Receiving Party will furnish only that portion of the Confidential Information that it is advised by counsel is legally required whether or not a protective order or other similar order is obtained by the Disclosing Party.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Securities Filings</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  In the event a Party proposes to file with the U.S. Securities and Exchange Commission or the securities regulators of any state or other jurisdiction a registration statement or any other disclosure document which describes or refers to this Agreement under the Securities Act, the Securities Exchange Act, of 1934, as amended, or any other applicable securities laws, such Party will notify the other Party in writing of such intention and will provide such other Party with a copy of relevant portions of the proposed filing not less than five (5) days prior to such filing (and any revisions to such portions of the proposed filing a reasonable time prior to the filing thereof), including without limitation any appendices to this Agreement, will consider in good faith the other Party&#8217;s comments and will use reasonable efforts to obtain confidential treatment of any information concerning this Agreement that such other Party requests, no later than two (2) days prior to such filing, be kept confidential, and will only disclose Confidential Information that it is advised by counsel is legally required to be disclosed.  No such notice will be required under this Section 5.5 if the substance of the description of or reference to this</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">19</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> Agreement contained in the proposed filing has been included in any previous filing made by the either Party hereunder or otherwise approved by the other Party.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5.6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Disclosure of Agreement</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Except as otherwise permitted under Section 5.3.3, neither Party may issue any press release or make any other public statement or other disclosure disclosing to any Third Party any information relating to this Agreement or its terms or the transactions contemplated hereby without the prior written consent of the other Party, such consent not to be unreasonably withheld, delayed, or conditioned.</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">PATENT MATTERS</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">6.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Preparation, Filing, Prosecution, and Maintenance of Palvella Patents</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">.  Palvella will have the responsibility, at its expense, and considering in good faith any and all recommendations of Ligand, for the preparation, filing, prosecution, and maintenance of the Palvella Patents, including any patent term extensions. Palvella will deliver to Ligand within </font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#91;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">***</font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#93;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;"> after the end of each Calendar Quarter a written report summarizing in reasonable detail the efforts of Palvella in the prior Calendar Quarter with respect to the preparation, filing, prosecution and maintenance of the Palvella Patents. Palvella will provide Ligand with notice of its intention to (a) permit any of the Palvella Patents to be abandoned in any country in the Territory or (b) elect not to file a new patent application claiming priority to a patent application within the Palvella Patents, either before such patent application&#8217;s issuance or within the time period required for the filing of an international (i.e., Patent Cooperation Treaty), regional (including the European Patent Office) or national patent application, in each case, at least </font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#91;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">***</font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#93;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;"> prior to such lapse or abandonment. In the event of any such lapse or abandonment, Ligand may elect to assume full responsibility for the continued prosecution and maintenance of such Palvella Patents, or the filing of such new patent application, in each case, upon obtaining Palvella&#8217;s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. </font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">_______________________________</font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">20</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Intellectual Property Matters</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">. </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Procedures and Requirements</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">In the event that either Party has cause to believe that a Third Party may be infringing or misappropriating any of the Palvella Patents in the Field in the Territory, it will promptly notify the other Party in writing, identifying the alleged infringer and the alleged infringement or misappropriation complained of and furnishing the information upon which such determination is based.  Palvella will have the first right but not the obligation to stop such infringement or misappropriation of the Palvella Patents by such Third Party in the Field in the Territory or settle, pursuant to Section 6.2.2, with such Third Party.  If Palvella fails to take action within &#91;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">***</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#93; following its receipt of a notice of such infringement or misappropriation, then Ligand, upon Palvella&#8217;s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed will have the right to take action to stop such infringement or misappropriation.  Upon reasonable request by the Party enforcing Palvella Patents in the Field in the Territory (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Enforcing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;), the other Party (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Non-Enforcing Party</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) will give the Enforcing Party all reasonable information and assistance, including without limitation allowing the Enforcing Party access to the Non-Enforcing Party&#8217;s files and documents and to the Non-Enforcing Party&#8217;s personnel who may have possession of relevant information and, if necessary or desirable for the Enforcing Party to prosecute any legal action, joining in the legal action as a party using counsel of its own choosing.  Any such assistance provided by a Non-Enforcing Party will be rendered at the Enforcing Party&#8217;s cost and expense and the Enforcing Party will reimburse the Non-Enforcing Party for its reasonable and documented costs and expenses upon the Non-Enforcing Party&#8217;s request.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.2.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Settlement of an Enforcement Claim</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The Enforcing Party will have the right to control settlement of any claims that a Third Party may be infringing or misappropriating any Palvella Patent in the Field and in the Territory&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that if such settlement could reasonably be deemed to have a material adverse effect on the Non-Enforcing Party, the Enforcing Party will not enter into any such settlement with respect to any Palvella Patent in the Territory without the prior written consent of the Non-Enforcing Party such consent not to be unreasonably withheld, delayed, or conditioned.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">6.2.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Expenses and Recovery</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">.  As between the Parties, the Enforcing Party will bear all costs and expenses (including without limitation any costs or expenses incurred that exceed the amounts recovered by the Enforcing Party pursuing any action under this Section 6.2.3) and payments awarded against or agreed to be paid by the Enforcing Party.  Any amounts recovered by either Party pursuant to Section 6.2.1 or 6.2.2, whether by settlement or judgment, will be allocated in accordance with the following&#58; </font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#91;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">***</font><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:7.8pt;line-height:120%;vertical-align:top;">&#93;</sup><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">. </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">_______________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">21</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Infringement Claims by Third Parties</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Ligand and Palvella each will promptly inform the other Party in writing of any actual, threatened, or alleged infringement or misappropriation, based on the making, using, selling, or offering for sale of a Product in the Field in the Territory, of a Third Party&#8217;s intellectual property rights of which it becomes aware.  Neither Party will acknowledge to a Third Party the validity of any such allegation or admit liability with respect to any Product without the prior written consent of the other Party.  Ligand and Palvella will each keep the other advised of all material developments in the conduct of any proceedings in defending any claim of such alleged infringement or misappropriation and will cooperate with the other in the conduct of such defense.  In no event may either Party settle any such infringement or misappropriation claim in a manner that would materially adversely affect or impose any obligation on the other Party, without such other Party&#8217;s prior written consent, such consent not to be unreasonably withheld, delayed, or conditioned.  Each Party will have the sole responsibility, at its cost and in its sole discretion, for defending any such allegations or claims made against it.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Limitation on Reporting Obligations</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">. Ligand acknowledges and agrees that (a) Palvella shall not be in breach of any of its obligations under this Agreement for failing to disclose any information of a Third Party that is not expressly required to be disclosed under this Agreement, including notices, correspondence or reports, that Palvella is not permitted to disclose under its confidentiality obligations to such Third Party, and (b) Ligand may be excluded from access to any information or material if Palvella determines in good faith that such exclusion is reasonably necessary to preserve the attorney-client privilege or other similar privilege&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">that Palvella will notify Ligand of any such exclusion and, at Ligand&#8217;s request, will enter into a common interest agreement or similar agreement that will permit disclosure of such information or material while preserving the attorney-client privilege or other similar privilege. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Patent Marking</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Palvella will include in all package inserts for all Products in each country in the Territory in which Products are commercialized a patent notice that includes the patent numbers of all Palvella Patents that Cover such Product, its method of manufacture or use in such country. </font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 7</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">TERM AND TERMINATION</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Term and Expiration</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The term of this Agreement will commence on the Effective Date, and will continue for as long as payments are due or payable under this Agreement, or until such date as this Agreement is sooner terminated in accordance with Section 7.2 or 7.3 or by mutual written consent of the Parties (the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Term</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;).  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Termination by Ligand</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">. Ligand may terminate this Agreement for any or no reason upon ninety (90) days prior written notice to Palvella.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Termination for Material Breach</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.3.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If Ligand believes that Palvella is in material breach of this Agreement, then Ligand may deliver notice of such breach to Palvella.  In such notice Ligand will identify with specificity the alleged breach and the actions or conduct that it wishes Palvella to take for an acceptable and prompt cure of such breach&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that such identified actions will not be binding upon Palvella with respect to the</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">22</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> actions that it may need to take to cure such breach.  Palvella will have ninety (90) days to cure such breach.  If Palvella fails to cure such breach within such cure period, Ligand may, subject to Section 7.3.2, terminate this Agreement immediately by providing Palvella a written notice at the end of such cure period.  Notwithstanding the foregoing, if Palvella fails to cure such breach within such cure period, but within such cure period Palvella is using commercially reasonable efforts to cure such breach, then Ligand may not terminate this Agreement for so long as Palvella is using commercially reasonable efforts to cure such breach.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.3.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Notwithstanding the foregoing, if Palvella disputes in good faith the existence or materiality of such breach and provides notice to Ligand of such dispute within such cure period, Ligand will not have the right to terminate this Agreement in accordance with this Section 7.3 unless and until it has been determined in accordance with Article 11 that this Agreement was materially breached by Palvella and Palvella failed to cure such breach within the applicable cure period.  It is understood and acknowledged that during the pendency of such a dispute, all of the terms and conditions of this Agreement will remain in effect and the Parties will continue to perform all of their respective obligations hereunder.  The Parties further agree that any payments that are made by one Party to the other Party pursuant to this Agreement pending resolution of the dispute will be promptly refunded if a court or arbitrator determines pursuant to Article 11 that such payments are to be refunded by one Party to the other Party.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Continuing Obligations</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">. Upon expiration or termination of this Agreement&#58;  (a) neither Party will be relieved of any obligation that accrued prior to the effective date of such termination and (b) all amounts due or payable to Ligand that were accrued prior to the effective date of termination will remain due and payable&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that the foregoing will not be deemed to limit Palvella&#8217;s indemnification obligations under this Agreement for acts or omissions occurring prior to the effective date of such termination that are the subject of such indemnification even if the indemnification amount cannot be accrued or determined as of the effective date of such termination.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Retention of Payments</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">. Upon expiration or termination of this Agreement, Ligand will have the right to retain all amounts previously paid to Ligand by Palvella.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">7.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Survival</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Expiration or termination of this Agreement for any reason will not (a) release any Party from any obligation that has accrued prior to the effective date of such expiration or termination, (b) preclude any Party from claiming any other damages, compensation, or relief that it may be entitled to upon such expiration or termination, or (c) terminate any right to obtain performance of any obligation provided for in this Agreement that will survive expiration or termination.  Without limiting the foregoing, upon expiration or termination of this Agreement, the rights and obligations of the Parties under Sections 7.4, 7.5, and this Section 7.6 and Articles 1, 5 (for the term set forth in Section 5.1), 8, 10, 11, and 12 will survive such expiration or termination. </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:center;margin-bottom:12pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">23</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 8</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">INDEMNITY</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">8.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Palvella Indemnity Obligations</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will defend Ligand, its Affiliates, and their respective directors, officers, employees, contractors, and agents (collectively, the &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Indemnitees</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;), and will indemnify and hold harmless the Indemnitees, from and against any liabilities, losses, costs, damages, fees, or expenses incurred by such Indemnitees, and reasonable attorney&#8217;s fees and other legal expenses with respect thereto, (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Losses&#8221;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">)</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">arising out of any allegation, claim, action, lawsuit, or other proceeding (&#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Claims</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;) brought against any Indemnitee to the extent directly resulting from or relating to&#58; (a) any breach by Palvella of any of its representations, warranties, covenants, or obligations pursuant to this Agreement, (b) research, Development, manufacturing, Commercialization, transfer, importation or exportation, labeling, handling or storage, or use of or other exploitation of any Product by or on behalf of Palvella, its Affiliates, Licensees, distributors, or contractors, including without limitation Claims brought following the Effective Date based on product liability, bodily injury, risk of bodily injury, death, or property damage, (c) any allegations of infringement or misappropriation of the intellectual property of any Third Party, (d) the gross negligence or willful misconduct, or (e) any violation of Applicable Law by Palvella, its Affiliates, or Licensees&#59; except in any such case to the extent such Losses and Claims directly result from&#58; (i) the gross negligence or willful misconduct of Ligand, (ii) any breach by Ligand of any of its representations, warranties, covenants, or obligations pursuant to this Agreement, or (iii) any violation of Applicable Law by Ligand.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">8.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Procedure</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  If any Indemnitee intends to claim indemnification under this Article 8, the Indemnitee will promptly notify Palvella in writing of any Claim in respect of which the Indemnitee intends to claim such indemnification, and Palvella will assume the defense thereof with counsel selected by Palvella and reasonably acceptable to the Indemnitee&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that an Indemnitee will have the right to retain its own counsel, with the fees and expenses to be paid by the Indemnitee, if representation of such Indemnitee by the counsel retained by Palvella would be inappropriate due to actual or potential differing interests between such Indemnitee and any other Party represented by such counsel in such proceedings.  Palvella will have the right to control the defense of, and settle, dispose of or compromise any Claims for which it is providing indemnification under this Article 8&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that the prior written consent of the Indemnitee (which will not be unreasonably withheld, delayed, or conditioned) will be required in the event any such settlement, disposition or compromise would adversely affect the interests of the Indemnitee.  The failure to deliver notice to Palvella within a reasonable time after the commencement of any such action, to the extent prejudicial to Palvella&#8217;s ability to defend such action, will relieve Palvella of any liability to the Indemnitee under this Article 8, but the omission to so deliver notice to Palvella will not relieve it of any liability that it may have to any Indemnitee otherwise than under this Article 8.  The Indemnitee under this Article 8, its employees, and its agents, will cooperate with Palvella and its legal representatives in the investigation of any Claim covered by this indemnification.</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">REPRESENTATIONS, WARRANTIES, AND COVENANTS</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">24</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Mutual Representations and Warranties</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Each Party represents and warrants to the other Party that&#58;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.1.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it has the requisite corporate power and authority to enter into and perform its obligations under this Agreement&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.1.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it has full legal power to extend the rights granted to the other under this Agreement&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.1.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it is not aware of any impediment that would inhibit its ability to perform the terms and conditions imposed on it by this Agreement&#59; and </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.1.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it has taken all necessary action on its part required to authorize the execution and delivery of this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Further Representations and Warranties, and Covenants, of Palvella</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Palvella represents and warrants as of the Effective Date, and Palvella covenants, that&#58;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it has enforceable written agreements with all of its employees, consultants, or independent contractors who receive Confidential Information under this Agreement obligating them to keep such information confidential and to use such information only as permitted in this Agreement, and assigning to Palvella ownership of all intellectual property rights created in the course of their employment&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">as of the Effective Date, it has the full right to grant the rights to receive payments granted to Ligand under this Agreement, and is not currently bound by any agreement with any Third Party, or by any outstanding order, judgment, or decree of any court or administrative agency, that restricts it from granting to Ligand the rights as set forth in this Agreement&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">it has not granted as of the Effective Date any right, option, license or interest in or to any Palvella Patents or Regulatory Filings that is in conflict with the rights granted to Ligand under this Agreement&#59; and it has not granted, or permitted to be attached, any lien, security interest, or other encumbrance with respect to the Palvella Patents or Regulatory Filings&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">During the Term, Palvella will not create, incur, assume or suffer to exist any lien, security interest, or other encumbrance on the Palvella Patents or Regulatory Filings, except to the extent that such lien, security interest, or encumbrance does not have an adverse effect on the interest of Ligand in PTX-022, including the right to receive payments and related information under this Agreement&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella has no Knowledge of any infringement or misappropriation by any Third Party of any of the Palvella Patents or Regulatory Filings as of the Effective Date&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">to Palvella&#8217;s Knowledge, Palvella solely owns the</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella Patents existing as of the Effective Date, including without limitation all patents and patent applications set forth on Appendix B, and such ownership has been duly recorded with the PTO or corresponding Governmental Authorities&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.7</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Appendix B contains a true and complete list of all patents and patent applications of the Palvella Patents as of the Effective Date&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">25</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.8</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella has not utilized and will not utilize, in the Development or Commercialization of a Product, any Person that at such time, to Palvella&#8217;s Knowledge, is debarred by FDA or other Regulatory Authority&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">9.2.9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">To Palvella&#8217;s Knowledge, Palvella has obtained, and during the Term will maintain, all licenses, authorizations, and permissions necessary under Applicable Law for meeting and performing its obligations under this Agreement and all such licenses, authorizations, and permissions are in full force and effect&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.10</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">To Palvella&#8217;s Knowledge, all of Palvella&#8217;s activities related to its use of Palvella Patents, and the Development and Commercialization of the Products comply in all material respects with Applicable Laws, and Palvella will use good faith efforts in compliance in all material respects with Applicable Laws during the Term&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.11</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella has not incurred, and does not presently intend to incur, debts, liabilities, or other obligations beyond its ability to pay such debts, liabilities, or other obligations as they become absolute and matured.  Palvella is not subject to any Bankruptcy Event, and no action has been taken or is intended by Palvella or, to its Knowledge, any other Person, to make Palvella subject to a Bankruptcy Event&#59; </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">9.2.12</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Palvella shall provide Ligand with written notice as promptly as possible (but in no event more than </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">) after acquiring Knowledge of the occurrence of a Bankruptcy Event in respect of Palvella&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.13</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">the claims and rights of Ligand created by this Agreement to receive the payments set forth in Article 4 are not and shall not be subordinated to any creditor of Palvella or any other Person (other than as a result of Ligand&#8217;s own election)&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella and, to its Knowledge, its Affiliates and Licensees and their respective employees and contractors have not, and Palvella and its Affiliates will not, and will use good faith efforts to cause its Licensees and their respective employees and contractors to not, directly or indirectly through Third Parties, pay, promise, or offer to pay, or authorize the payment of, any money or give any promise or offer to give, or authorize the giving of anything of value to a Public Official or Entity or other Person for purpose of obtaining or retaining business for or with, or directing business to, any Person, including without limitation Ligand or Palvella.  Without any limitation to the foregoing, Palvella and its Affiliates and Licensees and their respective employees and contractors have not, and Palvella and its Affiliates will not, and will use good faith efforts to cause its Licensees and their respective employees and contractors to not, directly or indirectly promise, offer, or provide any corrupt payment, gratuity, emolument, bribe, kickback, illicit gift, or hospitality or other illegal or unethical benefit to a Public Official or Entity or any other Person&#59;</font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">_______________________________</font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">26</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">15</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella is aware of all applicable anti-corruption and anti-bribery laws, including without limitation the FCPA, and all applicable anti-corruption laws in effect in the countries in which Palvella conducts or will conduct business.  Palvella and its Affiliates will not, and Palvella will use good faith efforts to cause its Licensees and their respective employees and contractors to not, cause any Indemnitees to be in violation of the FCPA, Export Control Laws, or any other Applicable Laws&#59;</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">16</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella and its Affiliates will fully cooperate and will use good faith efforts to cause its Licensees and their respective employees, contractors, and subcontractors to cooperate fully with the Indemnitees in ensuring compliance with the FCPA, Export Control Laws, and all other Applicable Laws.  During the Term, Palvella will provide Ligand with such due diligence information relating to compliance with the FCPA, Export Control Laws, and other Applicable Laws by Palvella and its Affiliates, subcontractors, and Licensees and their respective principals, directors, officers, employees, representatives, and contractors, as Ligand may reasonably request&#59; and</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.2.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">17</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Palvella will promptly notify Ligand if Palvella has any information or reasonable belief that there may be a violation of the FCPA, Export Control Laws, or any other Applicable Law in connection with the performance of this Agreement or the sale of the Product in the Territory.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">9.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Further Representations and Warranties of Ligand</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Ligand represents and warrants that, as of the Effective Date, Ligand is an Accredited Investor.</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 10</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">DISCLAIMER&#59; LIMITATION OF LIABILITY</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">10.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">DISCLAIMER</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  EXCEPT AS PROVIDED UNDER ARTICLE 9, EACH PARTY EXPRESSLY DISCLAIMS ANY AND ALL WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION THE WARRANTIES OF DESIGN, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES, OR ARISING FROM A COURSE OF DEALING, USAGE OR TRADE PRACTICES, IN ALL CASES WITH RESPECT THERETO.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">10.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">LIMITATION OF LIABILITY</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  </font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">10.2.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">NEITHER PARTY WILL BE LIABLE FOR INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, EXEMPLARY, PUNITIVE, OR MULTIPLE DAMAGES ARISING IN CONNECTION WITH THIS AGREEMENT OR THE EXERCISE OF ITS RIGHTS OR PERFORMANCE OF ITS OBLIGATIONS HEREUNDER, OR FOR LOST PROFITS OR LOSS OF USE ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF SUCH DAMAGES.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">10.2.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">NOTWITHSTANDING ANYTHING IN THIS AGREEMENT TO THE CONTRARY, SECTION 10.2.1 WILL NOT LIMIT OR RESTRICT (A) DAMAGES AVAILABLE FOR BREACHES OF CONFIDENTIALITY OBLIGATIONS UNDER ARTICLE 5, (B) THE INDEMNIFICATION OBLIGATIONS UNDER ARTICLE 8, OR (C) THE OBLIGATIONS TO PAY MILESTONE PAYMENTS AND ROYALTIES UNDER SECTIONS 4.2 AND 4.3.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">27</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">10.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">No Assumed Obligations</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Notwithstanding any provision in this Agreement, Ligand is not assuming any liability or obligation of Palvella or any of Palvella&#8217;s Affiliates of whatever nature, whether presently in existence or arising or asserted hereafter. All such liabilities and obligations shall be retained by and remain liabilities and obligations of Palvella or its Affiliates, as the case may be.</font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 11</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">DISPUTE RESOLUTION</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">11.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Resolution by Senior Executives</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The Parties will seek to settle amicably any and all disputes or differences arising out of or in connection with this Agreement.  Any dispute between the Parties will be promptly presented to the Chief Executive Officer of Palvella and the Chief Executive Officer of Ligand, or their respective designees, for resolution.  Such officers, or their designees, will attempt in good faith to promptly resolve such dispute. Notwithstanding the foregoing, either Party may seek equitable or interim relief or provisional remedy in any court of competent jurisdiction to enforce its rights under this Agreement, including without limitation injunctive relief and specific performance, without having to prove actual damages or post a bond. If the Chief Executive Officers of the Parties, or their respective designees, are unable to resolve a given dispute within thirty (30) days of the matter being referred to them, either Party may have the dispute adjudicated in accordance with Section 11.2.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">11.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Applicable Law and Venue.</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">  This Agreement will be governed by, enforced, and will be construed in accordance with the laws of the State of New York, United States of America without regard to any Applicable Law, rule, or principle that would result in the application of the laws of any other jurisdiction.  All actions and proceedings arising out of or relating to this Agreement will be heard and determined exclusively in any New York State or federal court sitting in the Southern District of New York, and each Party hereby irrevocably consents to personal jurisdiction and venue in, and agrees to service of process issued or authorized by, such court in any such action or proceeding and irrevocably waive any defense of an inconvenient forum to the maintenance of any such action or proceeding.  Notwithstanding the foregoing, either Party may seek injunctive relief in any court in any jurisdiction where appropriate.  </font></div><div style="text-align:center;margin-bottom:12pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">ARTICLE 12</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">MISCELLANEOUS</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Assignment</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  This Agreement may not be assigned or otherwise transferred by either Party without the consent of the other Party, which consent will not be unreasonably withheld, delayed, or conditioned&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided, however</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">, that either Party may, without such consent, assign this Agreement together with all of its rights and obligations hereunder to its Affiliates, or to a successor in interest in connection with the transfer or sale of all or substantially all of its business to which this Agreement relates, or in the event of a Change of Control, subject to the assignee agreeing to be bound by the terms of this Agreement and, if Palvella is the assigning Party, guarantees or similar or better credit support being provided, as necessary, to ensure that Ligand has substantially identical credit recourse.  Any purported assignment in violation of the preceding sentences will be void.  Any permitted assignee or successor will assume and be bound by all obligations of its assignor or predecessor under this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">28</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Severability</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  If any provision of this Agreement is held to be invalid or unenforceable, all other provisions will continue in full force and effect, and the Parties will substitute for the invalid or unenforceable provision a valid and enforceable provision which conforms as nearly as possible with the original intent of the Parties.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Notices</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Any notice or other communication to a Party pursuant to this Agreement will be sufficiently made or given on the date it was sent&#59; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:130%;">provided</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;"> that such notice or other communication is sent by first class certified or registered mail, postage prepaid, or is sent by next day express delivery service, addressed to it at its address in this Section 12.3, below, or to such other address as the Party to whom notice is to be given may have furnished to the other Party in writing in accordance herewith.</font></div><div style="padding-left:36pt;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">If to Ligand&#58;</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Ligand Pharmaceuticals, Inc.</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">3911 Sorrento Valley Boulevard, Suite 110</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#160;</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">San Diego, California 92121, U.S.A.</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Attention&#58;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Chief Financial Officer</font></div><div style="padding-left:72pt;"><font><br></font></div><div style="text-indent:36pt;padding-right:9pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">With a copy to (which alone will not constitute notice)&#58;</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Ligand Pharmaceuticals, Inc.</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">3911 Sorrento Valley Boulevard, Suite 110</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#160;</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">San Diego, California 92121, U.S.A.</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Attention&#58;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">General Counsel</font></div><div style="padding-left:72pt;margin-bottom:8pt;"><font><br></font></div><div style="text-indent:36pt;padding-right:9pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">If to Palvella, to&#58;</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Palvella Therapeutics, Inc. </font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">125 Strafford Avenue, Suite #360</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#160;</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Wayne, PA 19087</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Attention&#58;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Wes Kaupinen, President and CEO</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="text-indent:36pt;padding-right:9pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">With a copy to (which alone will not constitute notice)&#58;</font></div><div style="padding-right:9pt;"><font><br></font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Hogan Lovells US LLP</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">100 International Drive, Suite 2000</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#160;</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Baltimore, MD 21202</font></div><div style="padding-left:72pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Attention&#58;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">Asher M. Rubin</font></div><div style="padding-left:72pt;"><font><br></font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Expenses</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Except as expressly set forth in this Agreement or as may be specifically agreed to in writing by Palvella and Ligand, each Party will be responsible for all costs and expenses it incurs in connection with this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Headings</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The headings of Articles and Sections of this Agreement are for ease of reference only and will not affect the meaning or interpretation of this Agreement in any way.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">29</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.6</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Waiver</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The failure of either Party in any instance to insist upon the strict performance of the terms of this Agreement will not be construed to be waiver or relinquishment of any of the terms of this Agreement, either at the time of the Party&#8217;s failure to insist upon strict performance or at any time in the future, and such terms will continue in full force and effect.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.7</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Counterparts&#59; Electronic Delivery</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  This Agreement and any amendment may be executed in one or more counterparts (including without limitation by way of PDF or electronic transmission), each of which will be deemed an original, but all of which together will constitute one and the same instrument.  When executed by the Parties, this Agreement will constitute an original instrument, notwithstanding any electronic transmission, storage and printing of copies of this Agreement from computers or printers.  For clarity, PDF signatures will be treated as original signatures.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.8</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Use of Names</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Neither Party will, without prior written consent of the other Party, use the name or any trademark or trade name owned by the other Party, or owned by an Affiliate of the other Party, in any publication, publicity, advertising, or otherwise, except as expressly permitted by Article 5.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.9</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Independent Contractors</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Nothing contained in this Agreement will be deemed to constitute a joint venture, partnership, or employer-employee relationship between Ligand and Palvella, or to constitute one as the agent of the other.  Neither Party will be entitled to any benefits applicable to employees of the other Party.  Both Parties will act solely as independent contractors, and nothing in this Agreement will be construed to make one Party an agent, employee, or legal representative of the other Party for any purpose or to give either Party the power or authority to act for, bind, or commit the other Party.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.10</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Entire Agreement</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  This Agreement, together with the Appendices attached hereto, constitutes the entire agreement and understanding between the Parties with respect to the subject matter hereof, and supersedes all prior or contemporaneous proposals, oral or written, confidentiality agreements, and all other communications between the Parties with respect to such subject matter, including without limitation the Prior CDA.  </font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.11</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Modifications</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The terms and conditions of this Agreement may not be amended or modified, except in writing signed by both Parties.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.12</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Exports</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  The Parties acknowledge that the export of technical data, materials, or products is subject to the exporting Party receiving any necessary export licenses and that the Parties cannot be responsible for any delays attributable to export controls which are beyond the reasonable control of either Party.  Palvella and Ligand agree not to export or re-export, directly or indirectly, any information, technical data, the direct product of such data, samples, or equipment received or generated under this Agreement in violation of any applicable export control laws.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.13</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Further Assurances</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Each Party agrees to do and perform all such further reasonable acts and things and will execute and deliver such other agreements, certificates, instruments, and documents necessary to carry out the intent and accomplish the purposes of this Agreement.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Interpretation</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14.1</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">This Agreement was prepared in the English language, which language will govern the interpretation of, and any dispute regarding, the terms of this Agreement.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">30</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14.2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Each of the Parties acknowledges and agrees that this Agreement has been diligently reviewed by and negotiated by and between them, that in such negotiations each of them has been represented by competent counsel and that the final agreement contained herein, including without limitation the language whereby it has been expressed, represents the joint efforts of the Parties and their counsel.  Accordingly, in the event an ambiguity or a question of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the Parties and no presumption or burden of proof will arise favoring or disfavoring any Party by virtue of the authorship of any provisions of this Agreement.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14.3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">The definitions of the terms herein will apply equally to the singular and plural forms of the terms defined.  Whenever the context may require, any pronoun will include the corresponding masculine, feminine, and neuter forms.  The word &#8220;any&#8221; will mean &#8220;any and all&#8221; unless otherwise clearly indicated by context.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14.4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">Unless the context requires otherwise, (a) any definition of or reference to any agreement, instrument, or other document herein will be construed as referring to such agreement, instrument, or other document as from time to time amended, supplemented, or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein), (b)&#160;any reference to any Applicable Laws herein will be construed as referring to such Applicable Laws as from time to time enacted, repealed, or amended, (c) any reference herein to any Person will be construed to mean the Person&#8217;s successors and assigns (after any such succession or assignment), (d)&#160;the words &#8220;herein&#8221;, &#8220;hereof&#8221; and &#8220;hereunder&#8221;, and words of similar import, will be construed to refer to this Agreement in its entirety and not to any particular provision hereof, and (e) all references herein to Articles, Sections, or Appendices, unless otherwise specifically provided, will be construed to refer to Articles, Sections, and Appendices of this Agreement.</font></div><div style="text-indent:72pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.14.5</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">References to sections of the Code of Federal Regulations and to the United States Code will mean the cited sections, as these may be amended from time to time.</font></div><div style="text-indent:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">12.15</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Force Majeure Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">.  Except for the payment of money, neither Party will be in breach or default, nor will either Party be liable or responsible to the other Party for losses or damages, nor will either Party have the right to terminate this Agreement, for any breach, default or delay by the other Party that is attributable to an event beyond their reasonable control, including without limitation acts of God, acts of government (including without limitation injunctions), fire, flood, earthquake, strike, lockout, labor dispute, breakdown of plant, shortage of equipment or supplies, loss or unavailability of manufacturing facilities or materials, casualty or accident, stoppage or interruption of transportation or utilities, civil commotion, acts of public enemies, acts of terrorism or threat of terrorist acts, blockage or embargo and the like (each, a &#8220;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:130%;">Force Majeure Event</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:130%;">&#8221;)&#59; provided, however, that such Party will use commercially reasonable efforts to avoid and&#47;or minimize the impact of such occurrence, and give prompt written notice of any Force Majeure Event to the other Party.  </font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:120%;">Signature Page Follows</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#93;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;line-height:120%;">&#160;</font></div><div id="i_0_4"></div><div style="text-align:justify;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">31</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:justify;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">IN WITNESS WHEREOF</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">, each of the Parties has caused its duly authorized officer to execute and deliver this Agreement as of the Effective Date.</font></div><div style="padding-right:9pt;"><font><br></font></div><div><font><br></font></div><div style="padding-left:144pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS, INC.</font></div><div style="padding-left:144pt;"><font><br></font></div><div style="padding-left:144pt;"><font><br></font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">By&#58; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#47;s&#47; Matthew Korenberg</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">Name&#58; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">Matthew Korenberg</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">Title&#58;  </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">Chief Financial Officer and EVP Finance</font></div><div><font><br></font></div><div><font><br></font></div><div style="padding-left:144pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">PALVELLA THERAPEUTICS, INC. </font></div><div style="padding-left:144pt;"><font><br></font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">By&#58; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#47;s&#47; Wesley H. Kaupinen</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">Name&#58; </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">Wesley H. Kaupinen</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font></div><div style="padding-left:153pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;">Title&#58;  </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">President &#38; CEO</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:240%;text-decoration: underline;">&#160;</font></div><div style="padding-left:144pt;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;Signature Page to Development Funding and Royalties Agreement&#93;</font></div><div id="i_0_7"></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">1</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;">Appendix A</font></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;text-decoration: underline;">PTX-022</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;">&#160;</font></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">PTX-022 is a novel, </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;"> high-strength rapamycin topical &#91;***&#93; formulation &#91;***&#93;, optimized for dermal targeting, which is the subject of clinical development pursuant to FDA IND No. 117347. </font></div><div style="text-indent:-108pt;padding-left:144pt;"><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;">&#160;</font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">_______________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div id="i_0_10"></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">2</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;">Appendix B</font></div><div style="text-indent:-108pt;padding-left:108pt;text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;text-decoration: underline;">Palvella Patents</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:180%;">&#160;</font></div><div style="text-indent:-108pt;padding-left:108pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93;</font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">_____________________________</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div id="i_0_13"></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">3</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Appendix C</font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;text-decoration: underline;">Development Plan</font></div><div style="text-align:center;"><font><br></font></div><div style="text-indent:-18pt;padding-left:36pt;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Wingdings;font-size:12pt;font-weight:700;line-height:120%;">&#8226;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;padding-left:6pt;">Secure FDA </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-style:italic;font-weight:700;line-height:120%;">Fast Track Designation</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;"> as basis for expedited development and review (Achieved on November 5, 2018)</font></div><div style="text-indent:-18pt;padding-left:72pt;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">o</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">Provides for rolling review of NDA submission</font></div><div style="text-indent:-18pt;padding-left:72pt;margin-top:3pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">o</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">Opportunity for Priority Review (Priority Review designation means FDA's goal is to take action on an NDA within 6 months, compared to 10 months under standard review)</font></div><div style="text-indent:-18pt;padding-left:36pt;text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">&#8226;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;padding-left:13.8pt;">&#91;***&#93;</font></div><div><font><br></font></div><div><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">______________________________</font></div><div style="margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div id="i_0_16"></div><div style="text-align:center;"></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">4</font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;">Appendix D</font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:700;line-height:120%;text-decoration: underline;">Development Budget</font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:justify;margin-bottom:8pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:120%;">&#91;***&#93;</font></div><div><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font><br></font></div><div style="margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;font-weight:400;line-height:120%;">_________________________</font></div><div style="margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:12pt;line-height:115%;">&#91;***&#93; Certain information on this page has been omitted and filed separately with the Commission.  Confidential treatment has been requested with respect to the omitted portions.</font></div><div style="position:relative;width:100%;height:42.03pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">5</font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-21.1
<SEQUENCE>3
<FILENAME>lgnd123118exhibit211-n.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Exhibit 21.1</font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIGAND PHARMACEUTICALS INCORPORATED</font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">LIST OF SUBSIDIARIES</font></div><div><font><br></font></div><div><font><br></font></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:81.250000%;"><tr><td style="width:1.0%;"></td><td style="width:49.084813%;"></td><td style="width:1.0%;"></td><td style="width:0.1%;"></td><td style="width:2.339250%;"></td><td style="width:0.1%;"></td><td style="width:1.0%;"></td><td style="width:42.575937%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Name</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Jurisdiction of Incorporation</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Glycomed Incorporated &#160;&#160;&#160;&#160;</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">California</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Allergan Ligand Retinoid Therapeutics, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Pharmaceuticals International, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Biopharmaceuticals Incorporated</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand JVR, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Pharmaceuticals UK Limited</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">United Kingdom</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Ligand Pharmaceuticals (Canada) Incorporated</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Canada</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seragen Incorporated</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Seragen Technology, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Pharmacopeia, LLC</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis Therapeutics, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Neurogen Corporation</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">CyDex Pharmaceuticals, Inc. &#160;&#160;</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Open Monoclonal Technology, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OMT I, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">OMT II, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal Bioscience, Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">California</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis plc</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">England and Wales</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis (R&#38;D) Limited</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">England and Wales</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis Group Limited</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">England and Wales</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis Therapeutics Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Delaware</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis (Canada) Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Canada</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis (Canada II) Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Canada</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis Development Limited</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">England and Wales</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vernalis Research Limited</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">England and Wales</font></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cita NeuroPharmaceuticals Inc.</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Canada</font></td></tr></table></div><div><font><br></font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>lgnd123118exhibit231-n.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:40.5pt;width:100%;"><div><font><br></font></div></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Exhibit 23.1</font></div><div style="text-align:right;"><font><br></font></div><div style="text-align:center;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Consent of Ernst &#38; Young LLP, Independent Registered Public Accounting Firm</font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We consent to the incorporation by reference in the following Registration Statements&#58;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Registration Statement (Form S-8 No. 333-212775) pertaining to the 2002 Stock Incentive Plan, as amended and restated of Ligand Pharmaceuticals Incorporated, </font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">2</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">) Registration Statement (Form S-8 No. 333-182547) pertaining to the 2002 Stock Incentive Plan, as amended and restated of Ligand Pharmaceuticals Incorporated, </font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">3</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">) Registration Statement (Form S-8 No. 333-160132) pertaining to the 2002 Stock Incentive Plan, as amended and restated, and Employee Stock Purchase Plan, as amended and restated of Ligand Pharmaceuticals Incorporated, and</font></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">4</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">) Registration Statement (Form S-8 No. 333-131029) pertaining to the 2002 Stock Incentive Plan and 2002 Employee Stock Purchase Plan of Ligand Pharmaceuticals Incorporated&#59; </font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">of our reports dated </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">, with respect to the consolidated financial statements of Ligand Pharmaceuticals Incorporated and the effectiveness of internal control over financial reporting of Ligand Pharmaceuticals Incorporated included in this Annual Report (Form 10-K) of Ligand Pharmaceuticals Incorporated for the year ended </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">December&#160;31, 2018</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div><font><br></font></div><div style="text-indent:252pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#47;s&#47; Ernst &#38; Young LLP</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">San Diego, California</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</font></div><div><font><br></font></div><div style="position:relative;width:100%;height:130.5pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-31.1
<SEQUENCE>5
<FILENAME>lgnd123118exhibit311-n.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Exhibit </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">31.1</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">I, John L. Higgins, certify that&#58;</font></div><div style="margin-bottom:7pt;"><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:90.064103%;"><tr><td style="width:1.0%;"></td><td style="width:10.811388%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:85.188612%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">1.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">I have reviewed this Annual Report on Form 10</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">-</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">K of Ligand Pharmaceuticals Incorporated&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">2.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">3.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">4.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The registrant&#8217;s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have&#58;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">a)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">b)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">c)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">d)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">disclosed in this report any change in the registrant&#8217;s internal control over financial reporting that occurred during the registrant&#8217;s most recent fiscal quarter (the registrant&#8217;s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant&#8217;s internal control over financial reporting&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">5.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions)&#58;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">a)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">b)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.</font></div></td></tr></table></div><div><font><br></font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Date&#58;&#160;&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:98.000000%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">&#47;s&#47; John L. Higgins</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">John L. Higgins</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Chief Executive Officer</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">(Principal Executive Officer)</font></div></td></tr></table></div><div><font><br></font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-31.2
<SEQUENCE>6
<FILENAME>lgnd123118exhibit312-n.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">Exhibit </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">31.2</font></div><div><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">I, Matthew Korenberg, certify that&#58;</font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">1.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">I have reviewed this Annual Report on Form 10-K of Ligand Pharmaceuticals Incorporated&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">2.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">3.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">4.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The registrant&#8217;s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have&#58;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">a)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">b)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles&#59;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">c)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">evaluated the effectiveness of the registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">d)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">disclosed in this report any change in the registrant&#8217;s internal control over financial reporting that occurred during the registrant&#8217;s most recent fiscal quarter (the registrant&#8217;s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant&#8217;s internal control over financial reporting&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:9.538462%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.461538%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:36pt;padding-right:2pt;text-align:right;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">5.</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The registrant's other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant's auditors and the audit committee of the registrant's board of directors (or persons performing the equivalent functions)&#58;</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">a)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant's ability to record, process, summarize and report financial information&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.990000%;"><tr><td style="width:1.0%;"></td><td style="width:17.230769%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:78.769231%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:72pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">b)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant's internal control over financial reporting.</font></div></td></tr></table></div><div style="margin-top:6pt;"><font><br></font></div><div style="margin-bottom:7pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Date&#58;&#160;&#160;&#160;&#160;</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">February&#160;28, 2019</font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:65.064103%;"><tr><td style="width:1.0%;"></td><td style="width:98.000000%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">&#47;s&#47; Matthew Korenberg</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Matthew Korenberg</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Executive Vice President, Finance and Chief Financial Officer</font></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">(Principal Financial Officer)</font></div></td></tr></table></div><div><font><br></font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-32.1
<SEQUENCE>7
<FILENAME>lgnd123118exhibit321-n.htm
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2019 Workiva -->
<title>Document</title></head><body><div id="i_0_1"></div><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div style="text-align:right;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:173%;">Exhibit 32.1</font></div><div style="text-align:right;"><font><br></font></div><div style="text-align:center;margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:173%;">CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER</font></div><div style="text-indent:36pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">In connection with the Annual Report of Ligand Pharmaceuticals Incorporated (the &#8220;Company&#8221;) on Form 10-K for the year ended </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">December&#160;31, 2018</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">, as filed with the Securities and Exchange Commission on the date hereof (the &#8220;Report&#8221;), I, John L. Higgins, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge&#58;</font></div><div style="text-indent:36pt;margin-bottom:7pt;"><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.358974%;"><tr><td style="width:1.0%;"></td><td style="width:7.677419%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:88.322581%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">(1)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The Report fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.839744%;"><tr><td style="width:1.0%;"></td><td style="width:9.556982%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:21.434992%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:24.966292%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:36.041734%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2)&#160;</font></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.</font></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Date&#58;</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:2pt;padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">&#47;s&#47; John L. Higgins</font></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">John L. Higgins</font></div><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:100%;">Chief Executive Officer</font></div><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:100%;">(Principal Executive Officer)</font></div></td></tr></table></div><div style="margin-top:6pt;"><font><br></font></div><div style="text-indent:36pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section&#160;18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.</font></div><div><font><br></font></div><div style="text-align:center;margin-bottom:6pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:173%;">CERTIFICATION OF PRINCIPAL FINANCIAL OFFICER</font></div><div style="text-indent:36pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">In connection with the Annual Report of Ligand Pharmaceuticals Incorporated (the &#8220;Company&#8221;) on Form 10-K for the year ended </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">December&#160;31, 2018</font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">, as filed with the Securities and Exchange Commission on the date hereof (the &#8220;Report&#8221;), I, Matthew Korenberg, </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">Executive </font><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">Vice President, Finance and Chief Financial Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge&#58;</font></div><div style="text-indent:36pt;margin-bottom:7pt;"><font><br></font></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.198718%;"><tr><td style="width:1.0%;"></td><td style="width:9.308562%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:86.691438%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">(1)</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The Report fully complies with the requirements of Section 13(a) or Section 15(d), as applicable, of the Securities Exchange Act of 1934, as amended&#59; and</font></div></td></tr></table></div><div><font><br></font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="height:72pt;width:100%;"><div><font><br></font></div></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.038462%;"><tr><td style="width:1.0%;"></td><td style="width:9.326861%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:20.168285%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:20.330097%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:7.870550%;"></td><td style="width:1.0%;"></td><td style="width:1.0%;"></td><td style="width:32.304207%;"></td><td style="width:1.0%;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2)&#160;</font></td><td colspan="12" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="padding-left:3pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.</font></div></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="15" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="display:none;"></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Date&#58;</font></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><font style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">February 28, 2019</font></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><div style="text-indent:2pt;padding-left:2pt;padding-right:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">&#47;s&#47; Matthew Korenberg</font></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="6" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="display:none;"></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:middle;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Matthew Korenberg</font></div><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:100%;">Executive Vice President, Finance and Chief Financial Officer</font></div><div style="padding-left:2pt;padding-right:2pt;text-align:center;margin-top:2pt;margin-bottom:2pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:100%;">(Principal Financial Officer)</font></div></td></tr></table></div><div style="margin-top:6pt;"><font><br></font></div><div style="text-indent:36pt;"><font style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:173%;">The foregoing certification is being furnished solely to accompany the Report pursuant to 18 U.S.C. Section 1350, and is not being filed for purposes of Section&#160;18 of the Securities Exchange Act of 1934, as amended, and is not to be incorporated by reference into any filing of the Company, whether made before or after the date hereof, regardless of any general incorporation language in such filing. A signed original of this written statement required by Section 906 has been provided to the Company and will be retained by the Company and furnished to the Securities and Exchange Commission or its staff upon request.</font></div><div><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="text-align:center;"><font><br></font></div><div style="position:relative;width:100%;height:72pt;width:100%;"><div style="position:absolute;bottom:0;width:100%;"><div><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>8
<FILENAME>lgnd-20181231.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2017 Workiva-->
<!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:lgnd="http://www.ligand.com/20181231" xmlns:xbrli="http://www.xbrl.org/2003/instance" xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric" xmlns:num="http://www.xbrl.org/dtr/type/numeric" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xmlns:link="http://www.xbrl.org/2003/linkbase" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.ligand.com/20181231">
  <xs:import namespace="http://fasb.org/srt/2018-01-31" schemaLocation="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd"/>
  <xs:import namespace="http://fasb.org/us-gaap/2018-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd"/>
  <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd"/>
  <xs:import namespace="http://www.xbrl.org/dtr/type/numeric" schemaLocation="http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd"/>
  <xs:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/country/2017-01-31" schemaLocation="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2018-01-31" schemaLocation="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/invest/2013-01-31" schemaLocation="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/stpr/2018-01-31" schemaLocation="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd"/>
  <xs:element id="lgnd_CashPaidtoAcquireBusiness" abstract="false" name="CashPaidtoAcquireBusiness" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AccruedStockRepurchases" abstract="false" name="AccruedStockRepurchases" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AcquiredInProcessResearchAndDevelopmentMember" abstract="true" name="AcquiredInProcessResearchAndDevelopmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceofConvertibleBondHedge" abstract="false" name="ExercisePriceofConvertibleBondHedge" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:perShareItemType"/>
  <xs:element id="lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" abstract="false" name="TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_RoyaltyPromactaMember" abstract="true" name="RoyaltyPromactaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" abstract="false" name="NonCashChangeInEstimatedFairValueOfContingentValueRights" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_MeasurementInputRemainingTermMember" abstract="true" name="MeasurementInputRemainingTermMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" abstract="true" name="LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" abstract="false" name="BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" abstract="false" name="AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_OfficeWinnershUnitedKingdomMember" abstract="true" name="OfficeWinnershUnitedKingdomMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeNineMember" abstract="true" name="ExercisePriceRangeNineMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" abstract="false" name="BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" abstract="false" name="AllowanceForDoubtfulAccountsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_TwoThousandTwoStockIncentivePlanMember" abstract="true" name="TwoThousandTwoStockIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PaymentsforConvertibleBondHedges" abstract="false" name="PaymentsforConvertibleBondHedges" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_MetabasisTherapeuticsMember" abstract="true" name="MetabasisTherapeuticsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" abstract="true" name="LicenseFeesMilestonesAndOtherProductOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ContingentLiabilityRollForward" abstract="true" name="ContingentLiabilityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_VariableRateComponentAxis" abstract="true" name="VariableRateComponentAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_AziyoandCorMatrixMember" abstract="true" name="AziyoandCorMatrixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CydexPharmaceuticalsIncMember" abstract="true" name="CydexPharmaceuticalsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeEightMember" abstract="true" name="ExercisePriceRangeEightMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_OMTInc.Member" abstract="true" name="OMTInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ResearchFacilityEmeryvilleCAMember" abstract="true" name="ResearchFacilityEmeryvilleCAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeFiveMember" abstract="true" name="ExercisePriceRangeFiveMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" abstract="false" name="CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_VestingPeriodTwoMember" abstract="true" name="VestingPeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_BasisOfPresentationTable" abstract="true" name="BasisOfPresentationTable" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:hypercubeItem" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" abstract="false" name="ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_IncreaseDecreaseinEquityMethodInvestment" abstract="false" name="IncreaseDecreaseinEquityMethodInvestment" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_RoyaltyEvomelaMember" abstract="true" name="RoyaltyEvomelaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CorporateHeadquartersSanDiegoCAMember" abstract="true" name="CorporateHeadquartersSanDiegoCAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" abstract="false" name="DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" abstract="false" name="ForecastedCashFlowsEffectiveInterestRatePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeTenMember" abstract="true" name="ExercisePriceRangeTenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DocumentAndEntityInformationAbstract" abstract="true" name="DocumentAndEntityInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" abstract="false" name="ThresholdBusinessDaysforRepaymentofPrincipal" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" abstract="false" name="BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_MeasurementInputCouponRateMember" abstract="true" name="MeasurementInputCouponRateMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" abstract="true" name="BioscienceandTechnologyBusinessCenterLawrenceKSMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeThreeMember" abstract="true" name="ExercisePriceRangeThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_SelexisMember" abstract="true" name="SelexisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_WarrantsSettled" abstract="false" name="WarrantsSettled" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="lgnd_PartnerAMember" abstract="true" name="PartnerAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" abstract="false" name="DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" abstract="false" name="IncomeTaxReconciliationExpiredTaxCreditsResearch" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" abstract="false" name="RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeElevenMember" abstract="true" name="ExercisePriceRangeElevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" abstract="false" name="PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" abstract="false" name="ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueNet" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AmendedESPPMember" abstract="true" name="AmendedESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OtherBalanceSheetDetailsAbstract" abstract="true" name="OtherBalanceSheetDetailsAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_EquityReceivedinRepaymentofNoteReceivable" abstract="false" name="EquityReceivedinRepaymentofNoteReceivable" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_IncomeTaxReconciliationContingentValueRights" abstract="false" name="IncomeTaxReconciliationContingentValueRights" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_NoteReceivableAmountDueUponTriggeringEvent" abstract="false" name="NoteReceivableAmountDueUponTriggeringEvent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" abstract="false" name="PaymentsToContingentValueRightHoldersFinancingActivity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_PartnerCMember" abstract="true" name="PartnerCMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" abstract="false" name="DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_PurchaseofCommonStockMember" abstract="true" name="PurchaseofCommonStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_LiabilityForContingentValueRightsCompanyCydexMember" abstract="true" name="LiabilityForContingentValueRightsCompanyCydexMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_RoyaltyOtherMember" abstract="true" name="RoyaltyOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" abstract="true" name="DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" abstract="false" name="DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_CrystalMember" abstract="true" name="CrystalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_RoyaltyKyprolisMember" abstract="true" name="RoyaltyKyprolisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_VestingPeriodOneMember" abstract="true" name="VestingPeriodOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" abstract="false" name="MaturityPeriodOfHighlyLiquidSecuritiesMaximum" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="lgnd_ResearchFacilityCambridgeUnitedKingdomMember" abstract="true" name="ResearchFacilityCambridgeUnitedKingdomMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" abstract="false" name="RevenueRoyaltytoAcquireeShareholdersPercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_CommercialLicenseRightsPolicyTextBlock" abstract="false" name="CommercialLicenseRightsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" abstract="false" name="PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_OtherAssetsCurrentOther" abstract="false" name="OtherAssetsCurrentOther" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeSevenMember" abstract="true" name="ExercisePriceRangeSevenMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_LicenseFeesMember" abstract="true" name="LicenseFeesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PaymentsToContingentValueRightHolders" abstract="false" name="PaymentsToContingentValueRightHolders" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" abstract="false" name="AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_WarrantsCurrent" abstract="false" name="WarrantsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" abstract="false" name="RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AziyoMember" abstract="true" name="AziyoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeTwoMember" abstract="true" name="ExercisePriceRangeTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_MaterialSalesCaptisolMember" abstract="true" name="MaterialSalesCaptisolMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_CashPayable" abstract="false" name="CashPayable" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_CommercialLicenseRights" abstract="false" name="CommercialLicenseRights" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeOneMember" abstract="true" name="ExercisePriceRangeOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CydexandCrystalMember" abstract="true" name="CydexandCrystalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" abstract="false" name="ThresholdRevenueAmounttoTriggerRoyaltyPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ProductRoyaltyPercentage" abstract="false" name="ProductRoyaltyPercentage" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" abstract="false" name="ChangeInDerivativeAssetAndLiabilityFairValue" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_Phase3ClinicalTrialMember" abstract="true" name="Phase3ClinicalTrialMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_MilestoneMember" abstract="true" name="MilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" abstract="false" name="VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" abstract="false" name="DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" abstract="true" name="LiabilityForContingentValueRightsCompanyCrystalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" abstract="false" name="ScheduleofCommercialLicenseRightsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_VernalisMember" abstract="true" name="VernalisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_RoyaltyAgreementExpirationPeriod" abstract="false" name="RoyaltyAgreementExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="lgnd_NoteReceivableCashDueUponTriggeringEvent" abstract="false" name="NoteReceivableCashDueUponTriggeringEvent" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AccruedInventoryPurchases" abstract="false" name="AccruedInventoryPurchases" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" abstract="false" name="IncomeTaxReconciliationChangeInUncertainTaxPositions" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" abstract="false" name="RevenueRecognitionMilestoneMethodMilestonePaymentReceived" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_CorMatrixMember" abstract="true" name="CorMatrixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ComputerEquipmentAndSoftwareMember" abstract="true" name="ComputerEquipmentAndSoftwareMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CorporateShareRepurchaseAbstract" abstract="true" name="CorporateShareRepurchaseAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_OwnershipInEntityByDirectorPercentage" abstract="false" name="OwnershipInEntityByDirectorPercentage" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_EmployeeStockPurchasePlanAbstract" abstract="true" name="EmployeeStockPurchasePlanAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" abstract="false" name="IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_PalvellaTherapeuticsIncMember" abstract="true" name="PalvellaTherapeuticsIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ScheduleofContingentLiabilitiesTableTextBlock" abstract="false" name="ScheduleofContingentLiabilitiesTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_NumberofCollaborationAgreements" abstract="false" name="NumberofCollaborationAgreements" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="lgnd_BasisOfPresentationLineItems" abstract="true" name="BasisOfPresentationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeFourMember" abstract="true" name="ExercisePriceRangeFourMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_NumberOfContingentValueRightsIssued" abstract="false" name="NumberOfContingentValueRightsIssued" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" abstract="true" name="CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_VikingTherapeuticsInc.Member" abstract="true" name="VikingTherapeuticsInc.Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OfficeandResearchFacilityLaJollaCAMember" abstract="true" name="OfficeandResearchFacilityLaJollaCAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" abstract="false" name="ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:element id="lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" abstract="false" name="FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" abstract="true" name="ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PurchaseOfConvertibleBondHedge" abstract="false" name="PurchaseOfConvertibleBondHedge" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AccruedSalesReturns" abstract="false" name="AccruedSalesReturns" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_DeferredTaxLiabilitiesFairValueAdjustment" abstract="false" name="DeferredTaxLiabilitiesFairValueAdjustment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" abstract="false" name="BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_LiabilityForContingentValueRights" abstract="false" name="LiabilityForContingentValueRights" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_IncreaseDecreaseInContingentLiabilities" abstract="false" name="IncreaseDecreaseInContingentLiabilities" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_WorkingCapitalAdjustment" abstract="false" name="WorkingCapitalAdjustment" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_MilestonePaymentsAndRoyaltiesMember" abstract="true" name="MilestonePaymentsAndRoyaltiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_CydexMember" abstract="true" name="CydexMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" abstract="true" name="ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PartnerBMember" abstract="true" name="PartnerBMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OfficeEmeryvilleCAMember" abstract="true" name="OfficeEmeryvilleCAMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" abstract="false" name="ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" abstract="true" name="LiabilityForContingentValueRightsCompanyMetabasisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_PurchaseforCommercialLicenseRights" abstract="false" name="PurchaseforCommercialLicenseRights" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_LicenseFeesMilestonesandProductOtherMember" abstract="true" name="LicenseFeesMilestonesandProductOtherMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" abstract="false" name="EquityMethodInvestmentSharesReceivedLicensingAgreement" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" abstract="false" name="EffectiveIncomeTaxRateReconciliationChangeInDerivatives" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ConvertibleSeniorNotes2023Member" abstract="true" name="ConvertibleSeniorNotes2023Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" abstract="false" name="OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ConvertibleSeniorNotes2019Member" abstract="true" name="ConvertibleSeniorNotes2019Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" abstract="false" name="BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="num:percentItemType"/>
  <xs:element id="lgnd_CurrentPortionOfLiabilityForContingentValueRights" abstract="false" name="CurrentPortionOfLiabilityForContingentValueRights" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="lgnd_ExercisePriceRangeSixMember" abstract="true" name="ExercisePriceRangeSixMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_VariableRateComponentDomain" abstract="true" name="VariableRateComponentDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:domainItemType"/>
  <xs:element id="lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" abstract="false" name="FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="nonnum:textBlockItemType"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="lgnd-20181231_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="lgnd-20181231_def.xml" xlink:role="http://www.xbrl.org/2003/role/definitionLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="lgnd-20181231_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="lgnd-20181231_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="DocumentandEntityInformation" roleURI="http://www.ligand.com/role/DocumentandEntityInformation">
        <link:definition>0001001 - Document - Document and Entity Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETS" roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS">
        <link:definition>1001002 - Statement - CONSOLIDATED BALANCE SHEETS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDBALANCESHEETSParenthetical" roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical">
        <link:definition>1002003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFOPERATIONS" roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS">
        <link:definition>1003004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS">
        <link:definition>1004005 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY">
        <link:definition>1005006 - Statement - CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CONSOLIDATEDSTATEMENTSOFCASHFLOWS" roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS">
        <link:definition>1006007 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPolicies" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies">
        <link:definition>2101101 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies">
        <link:definition>2202201 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables">
        <link:definition>2303301 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails">
        <link:definition>2404401 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails">
        <link:definition>2405402 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails">
        <link:definition>2406403 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails">
        <link:definition>2407404 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails">
        <link:definition>2408405 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails">
        <link:definition>2409406 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InvestmentinViking" roleURI="http://www.ligand.com/role/InvestmentinViking">
        <link:definition>2110102 - Disclosure - Investment in Viking</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="InvestmentinVikingNarrativeDetails" roleURI="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails">
        <link:definition>2411407 - Disclosure - Investment in Viking - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessCombinations" roleURI="http://www.ligand.com/role/BusinessCombinations">
        <link:definition>2112103 - Disclosure - Business Combinations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessCombinationsTables" roleURI="http://www.ligand.com/role/BusinessCombinationsTables">
        <link:definition>2313302 - Disclosure - Business Combinations (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessCombinationsNarrativeDetails" roleURI="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails">
        <link:definition>2414408 - Disclosure - Business Combinations - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" roleURI="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails">
        <link:definition>2415409 - Disclosure - Business Combinations - Assets Acquired and Liabilities Assumed (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BusinessCombinationsConsiderationTransferredDetails" roleURI="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails">
        <link:definition>2416410 - Disclosure - Business Combinations - Consideration Transferred (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurement" roleURI="http://www.ligand.com/role/FairValueMeasurement">
        <link:definition>2117104 - Disclosure - Fair Value Measurement</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementTables" roleURI="http://www.ligand.com/role/FairValueMeasurementTables">
        <link:definition>2318303 - Disclosure - Fair Value Measurement (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" roleURI="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails">
        <link:definition>2419411 - Disclosure - Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" roleURI="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails">
        <link:definition>2420412 - Disclosure - Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeaseObligations" roleURI="http://www.ligand.com/role/LeaseObligations">
        <link:definition>2121105 - Disclosure - Lease Obligations</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeaseObligationsTables" roleURI="http://www.ligand.com/role/LeaseObligationsTables">
        <link:definition>2322304 - Disclosure - Lease Obligations (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeaseObligationsNarrativeDetails" roleURI="http://www.ligand.com/role/LeaseObligationsNarrativeDetails">
        <link:definition>2423413 - Disclosure - Lease Obligations - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" roleURI="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails">
        <link:definition>2424414 - Disclosure - Lease Obligations - Operating Lease Obligations and Payments (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConvertibleSeniorNotes" roleURI="http://www.ligand.com/role/ConvertibleSeniorNotes">
        <link:definition>2125106 - Disclosure - Convertible Senior Notes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConvertibleSeniorNotesTables" roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesTables">
        <link:definition>2326305 - Disclosure - Convertible Senior Notes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConvertibleSeniorNotesNarrativeDetails" roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails">
        <link:definition>2427415 - Disclosure - Convertible Senior Notes - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails">
        <link:definition>2428416 - Disclosure - Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetails">
        <link:definition>2129107 - Disclosure - Balance Sheet Account Details</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsTables" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsTables">
        <link:definition>2330306 - Disclosure - Balance Sheet Account Details (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsInvestmentCategoriesDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails">
        <link:definition>2431417 - Disclosure - Balance Sheet Account Details - Investment Categories (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsOtherCurrentAssetsDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails">
        <link:definition>2432418 - Disclosure - Balance Sheet Account Details - Other Current Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsPropertyandEquipmentDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails">
        <link:definition>2433419 - Disclosure - Balance Sheet Account Details - Property and Equipment (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails">
        <link:definition>2434420 - Disclosure - Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsAccruedLiabilitiesDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails">
        <link:definition>2435421 - Disclosure - Balance Sheet Account Details - Accrued Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="BalanceSheetAccountDetailsContingentLiabilitiesDetails" roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails">
        <link:definition>2436422 - Disclosure - Balance Sheet Account Details - Contingent Liabilities (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquity" roleURI="http://www.ligand.com/role/StockholdersEquity">
        <link:definition>2137108 - Disclosure - Stockholders' Equity</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityTables" roleURI="http://www.ligand.com/role/StockholdersEquityTables">
        <link:definition>2338307 - Disclosure - Stockholders' Equity (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityNarrativeDetails" roleURI="http://www.ligand.com/role/StockholdersEquityNarrativeDetails">
        <link:definition>2439423 - Disclosure - Stockholders' Equity - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityShareBasedCompensationDetails" roleURI="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails">
        <link:definition>2440424 - Disclosure - Stockholders' Equity - Share-Based Compensation (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityStockOptionPlanActivityDetails" roleURI="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails">
        <link:definition>2441425 - Disclosure - Stockholders' Equity - Stock Option Plan Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityBreakdownofOptionsOutstandingDetails" roleURI="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails">
        <link:definition>2442426 - Disclosure - Stockholders' Equity - Breakdown of Options Outstanding (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityAssumptionsDetails" roleURI="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails">
        <link:definition>2443427 - Disclosure - Stockholders' Equity - Assumptions (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="StockholdersEquityRestrictedStockActivityDetails" roleURI="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails">
        <link:definition>2444428 - Disclosure - Stockholders' Equity - Restricted Stock Activity (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="CommitmentsandContingenciesLegalProceedings" roleURI="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings">
        <link:definition>2145109 - Disclosure - Commitments and Contingencies: Legal Proceedings</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxes" roleURI="http://www.ligand.com/role/IncomeTaxes">
        <link:definition>2146110 - Disclosure - Income Taxes</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesTables" roleURI="http://www.ligand.com/role/IncomeTaxesTables">
        <link:definition>2347308 - Disclosure - Income Taxes (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesNarrativeDetails" roleURI="http://www.ligand.com/role/IncomeTaxesNarrativeDetails">
        <link:definition>2448429 - Disclosure - Income Taxes - Narrative (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" roleURI="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails">
        <link:definition>2449430 - Disclosure - Income Taxes - Components of Income Tax Expense (Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails">
        <link:definition>2450431 - Disclosure - Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesDeferredTaxesDetails" roleURI="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails">
        <link:definition>2451432 - Disclosure - Income Taxes - Deferred Taxes (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails">
        <link:definition>2452433 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofUnauditedQuarterlyFinancialInformation" roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation">
        <link:definition>2153111 - Disclosure - Summary of Unaudited Quarterly Financial Information</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofUnauditedQuarterlyFinancialInformationTables" roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables">
        <link:definition>2354309 - Disclosure - Summary of Unaudited Quarterly Financial Information (Tables)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
      <link:roleType id="SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails">
        <link:definition>2455434 - Disclosure - Summary of Unaudited Quarterly Financial Information - Summary (Details)</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
</xs:schema>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.CAL
<SEQUENCE>9
<FILENAME>lgnd-20181231_cal.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION CALCULATION LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2017 Workiva-->
<!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#DocumentandEntityInformation"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_e9f56cc2-6d96-475f-b596-26716885c13e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_ec48f0a2-bdb6-45ff-ba09-f68d14e4b46f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e9f56cc2-6d96-475f-b596-26716885c13e" xlink:to="loc_us-gaap_Liabilities_ec48f0a2-bdb6-45ff-ba09-f68d14e4b46f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_c97c1f88-d385-4eab-8be9-444b39475361" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e9f56cc2-6d96-475f-b596-26716885c13e" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_c97c1f88-d385-4eab-8be9-444b39475361" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c24716bc-d02b-4fd4-83a1-a9ca46f42a3b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e9f56cc2-6d96-475f-b596-26716885c13e" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c24716bc-d02b-4fd4-83a1-a9ca46f42a3b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_7b783954-d280-47f6-98a0-47f1af78ddb0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_e9f56cc2-6d96-475f-b596-26716885c13e" xlink:to="loc_us-gaap_StockholdersEquity_7b783954-d280-47f6-98a0-47f1af78ddb0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_bca19964-fac7-4e26-939b-1f65cc993c0b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_AssetsCurrent_bca19964-fac7-4e26-939b-1f65cc993c0b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_fc79747b-9303-4661-a58b-96e2e764f7fc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_fc79747b-9303-4661-a58b-96e2e764f7fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_53a6df17-75b7-457a-99bb-bc3ee27f04eb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_53a6df17-75b7-457a-99bb-bc3ee27f04eb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4d55aa40-ff74-4ac4-97c0-5263a6affbcd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_4d55aa40-ff74-4ac4-97c0-5263a6affbcd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_2b93f629-41b9-435f-bd2b-83f868e6bc57" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_Goodwill_2b93f629-41b9-435f-bd2b-83f868e6bc57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CommercialLicenseRights_b6093874-12ae-4311-ab91-386f722cce47" xlink:href="lgnd-20181231.xsd#lgnd_CommercialLicenseRights"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_lgnd_CommercialLicenseRights_b6093874-12ae-4311-ab91-386f722cce47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_a10e2e28-99fa-4c5e-a132-5ea437ceef61" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_a10e2e28-99fa-4c5e-a132-5ea437ceef61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_e8ebf421-18f3-4c0d-aa40-ddad94f6c343" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_778b0844-39b3-4980-a189-83624c5ae8ea" xlink:to="loc_us-gaap_EquityMethodInvestments_e8ebf421-18f3-4c0d-aa40-ddad94f6c343" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_61e8314b-df50-422d-ab10-c8ed185de040" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_61e8314b-df50-422d-ab10-c8ed185de040" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_31738788-e6b4-4699-8c08-f257ea71c6f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_ShortTermInvestments_31738788-e6b4-4699-8c08-f257ea71c6f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_41db920f-b9bc-401c-9603-875e5657cbd8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_41db920f-b9bc-401c-9603-875e5657cbd8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_570728fe-d20e-4274-acee-cebf2e97979d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_ReceivablesNetCurrent_570728fe-d20e-4274-acee-cebf2e97979d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesAndLoansReceivableGrossCurrent_ab8d9b9f-f6b9-4309-8ea3-ed0a996ad834" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesAndLoansReceivableGrossCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_NotesAndLoansReceivableGrossCurrent_ab8d9b9f-f6b9-4309-8ea3-ed0a996ad834" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_12b59c14-fbad-4948-a24c-da8fe3accc75" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_InventoryNet_12b59c14-fbad-4948-a24c-da8fe3accc75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_7de671e9-3e44-453a-96c9-22623edf88f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_7de671e9-3e44-453a-96c9-22623edf88f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_8d15f3b6-1b6a-4b17-82b9-6cc18fe51a9a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_bc90e32f-6adc-4e3b-9c27-9d9ce678671c" xlink:to="loc_us-gaap_OtherAssetsCurrent_8d15f3b6-1b6a-4b17-82b9-6cc18fe51a9a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_4d652eac-f807-4987-b0ba-88f945743f61" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_8b3adc19-f987-490b-b850-35e677bf6a8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d652eac-f807-4987-b0ba-88f945743f61" xlink:to="loc_us-gaap_LiabilitiesCurrent_8b3adc19-f987-490b-b850-35e677bf6a8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRights_96b130c5-2740-4347-bbd9-ce0a3277ed0a" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRights"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d652eac-f807-4987-b0ba-88f945743f61" xlink:to="loc_lgnd_LiabilityForContingentValueRights_96b130c5-2740-4347-bbd9-ce0a3277ed0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_e1fbf0d1-2943-491e-ae06-eef41f1b440f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d652eac-f807-4987-b0ba-88f945743f61" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_e1fbf0d1-2943-491e-ae06-eef41f1b440f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_07804888-f0bb-4847-b71a-efd62e875d8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_4d652eac-f807-4987-b0ba-88f945743f61" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_07804888-f0bb-4847-b71a-efd62e875d8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_df458589-e8ff-445d-b327-a1db6bdf8e90" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_us-gaap_AccountsPayableCurrent_df458589-e8ff-445d-b327-a1db6bdf8e90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_ac55d329-b30f-4ef2-a312-b091cd4e1277" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_ac55d329-b30f-4ef2-a312-b091cd4e1277" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights_2054db12-979e-4523-92b9-147d8abefa27" xlink:href="lgnd-20181231.xsd#lgnd_CurrentPortionOfLiabilityForContingentValueRights"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights_2054db12-979e-4523-92b9-147d8abefa27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_41c3633a-01c0-48d1-acf2-625f45093511" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_41c3633a-01c0-48d1-acf2-625f45093511" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_0915da8c-f639-4ca9-86a0-b916795c6f4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_0915da8c-f639-4ca9-86a0-b916795c6f4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_62b253a5-3e29-408e-a5c6-bea853bc687a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_c62d1776-f345-40e1-bb72-f5aad9f6fde5" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_62b253a5-3e29-408e-a5c6-bea853bc687a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_4f0d8464-6127-4f7e-8509-3633e5349216" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_608ba3e0-6e32-400f-aa44-3c3b06b8c9b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4f0d8464-6127-4f7e-8509-3633e5349216" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_608ba3e0-6e32-400f-aa44-3c3b06b8c9b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_b0aad58a-6d82-43f2-b154-73c7a5b15a8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4f0d8464-6127-4f7e-8509-3633e5349216" xlink:to="loc_us-gaap_CommonStockValue_b0aad58a-6d82-43f2-b154-73c7a5b15a8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_3b86ef32-e02a-4c80-a190-11303e7c1da0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4f0d8464-6127-4f7e-8509-3633e5349216" xlink:to="loc_us-gaap_AdditionalPaidInCapital_3b86ef32-e02a-4c80-a190-11303e7c1da0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_479530a7-f0e7-4de3-a87e-bb21ef42b8ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_4f0d8464-6127-4f7e-8509-3633e5349216" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_479530a7-f0e7-4de3-a87e-bb21ef42b8ec" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_2c4915da-99b2-4efe-a84f-787d5f581ace" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_4d525fae-2cf4-4709-9006-7e62aa1abd97" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2c4915da-99b2-4efe-a84f-787d5f581ace" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_4d525fae-2cf4-4709-9006-7e62aa1abd97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_4b52b288-6d2f-4186-b887-4f9dfc5faf76" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2c4915da-99b2-4efe-a84f-787d5f581ace" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_4b52b288-6d2f-4186-b887-4f9dfc5faf76" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_7c53490f-64fe-4d69-b35b-9675412faa56" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeNonoperating"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2c4915da-99b2-4efe-a84f-787d5f581ace" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_7c53490f-64fe-4d69-b35b-9675412faa56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_4afaf8bd-cfee-4eef-8906-6575ccc255d8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_2c4915da-99b2-4efe-a84f-787d5f581ace" xlink:to="loc_us-gaap_InterestExpense_4afaf8bd-cfee-4eef-8906-6575ccc255d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_da950eb1-47b8-49a7-a69f-05e9bf66a2f9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_660acc12-8d5b-4d1f-a224-4f6ae8987e9d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_da950eb1-47b8-49a7-a69f-05e9bf66a2f9" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_660acc12-8d5b-4d1f-a224-4f6ae8987e9d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_203c69bd-9626-452a-bf61-7ce959ceb690" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_da950eb1-47b8-49a7-a69f-05e9bf66a2f9" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_203c69bd-9626-452a-bf61-7ce959ceb690" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_359e13f3-d2f7-46db-a673-328c13f2810a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_fba0cfba-c554-4e05-8aea-36bb55a9a21c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_359e13f3-d2f7-46db-a673-328c13f2810a" xlink:to="loc_us-gaap_OperatingIncomeLoss_fba0cfba-c554-4e05-8aea-36bb55a9a21c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_d70ac95b-f8f1-4ca3-a1b3-36544e2623a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_359e13f3-d2f7-46db-a673-328c13f2810a" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_d70ac95b-f8f1-4ca3-a1b3-36544e2623a3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_e0dde856-49a3-4408-a513-70ecba3069c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_e83f57c6-2c9c-4f4c-948f-ddbafdcfa47a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_e0dde856-49a3-4408-a513-70ecba3069c1" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_e83f57c6-2c9c-4f4c-948f-ddbafdcfa47a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_2af8d1ca-16a9-4874-9727-a9c7564712d8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_e0dde856-49a3-4408-a513-70ecba3069c1" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_2af8d1ca-16a9-4874-9727-a9c7564712d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_abbceeb3-6296-4745-9193-6e57003d3d4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_04101a29-3652-442d-836b-fa238fe93527" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_abbceeb3-6296-4745-9193-6e57003d3d4c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_04101a29-3652-442d-836b-fa238fe93527" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_26e1bd4a-0ca2-495b-b9f8-d340d26f34bd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_abbceeb3-6296-4745-9193-6e57003d3d4c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_26e1bd4a-0ca2-495b-b9f8-d340d26f34bd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_7fe68ac7-b6be-4d9c-8fb2-6920555027cf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_dc59e9c7-acd2-4008-958f-3110e5c1c203" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_7fe68ac7-b6be-4d9c-8fb2-6920555027cf" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_dc59e9c7-acd2-4008-958f-3110e5c1c203" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_f19930c4-28c8-4fd5-99c6-0a6b1dd4f63c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareDiluted_7fe68ac7-b6be-4d9c-8fb2-6920555027cf" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_f19930c4-28c8-4fd5-99c6-0a6b1dd4f63c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_60b04df4-66dc-4cfd-a4b4-6b7101c0979f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_3ec02426-1b3d-4b85-bc51-df3c984dd317" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_60b04df4-66dc-4cfd-a4b4-6b7101c0979f" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_3ec02426-1b3d-4b85-bc51-df3c984dd317" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_684c3ef1-6846-4b19-9b09-8f33c0ebc19c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_60b04df4-66dc-4cfd-a4b4-6b7101c0979f" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_684c3ef1-6846-4b19-9b09-8f33c0ebc19c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_ca3c7432-82f2-4425-8eef-a6094f659df9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_95ff0614-7f92-418e-a708-b4e4a5c2a1bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingCostsAndExpenses_ca3c7432-82f2-4425-8eef-a6094f659df9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_95ff0614-7f92-418e-a708-b4e4a5c2a1bb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_3764e228-db11-4bdd-8053-d3c3399809aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingCostsAndExpenses_ca3c7432-82f2-4425-8eef-a6094f659df9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_3764e228-db11-4bdd-8053-d3c3399809aa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_e36c15e0-0788-4f5a-9878-63cc011bf8c2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSoldAmortization"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingCostsAndExpenses_ca3c7432-82f2-4425-8eef-a6094f659df9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_e36c15e0-0788-4f5a-9878-63cc011bf8c2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_7db93e2b-188a-4382-b783-632ab66b7d59" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingCostsAndExpenses_ca3c7432-82f2-4425-8eef-a6094f659df9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_7db93e2b-188a-4382-b783-632ab66b7d59" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_69447770-31e1-4750-830b-c30e7ff41032" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_be3b3849-2ad1-4496-b793-e03848f8f7cb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_69447770-31e1-4750-830b-c30e7ff41032" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_be3b3849-2ad1-4496-b793-e03848f8f7cb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_b972aff0-1a96-4dc6-a357-5aa6b1da5009" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_EarningsPerShareBasic_69447770-31e1-4750-830b-c30e7ff41032" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_b972aff0-1a96-4dc6-a357-5aa6b1da5009" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_779dbcdf-8cb9-4a52-b182-2f17bafaea7d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_1bbdf850-dd63-4802-96b2-a19e0eb43dc7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_779dbcdf-8cb9-4a52-b182-2f17bafaea7d" xlink:to="loc_us-gaap_NetIncomeLoss_1bbdf850-dd63-4802-96b2-a19e0eb43dc7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_3c73f3b3-1373-4ff3-8c5d-f7329d88314c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_779dbcdf-8cb9-4a52-b182-2f17bafaea7d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_3c73f3b3-1373-4ff3-8c5d-f7329d88314c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_cd7b5ce1-9580-4fa6-b14b-2c47a6f933cc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_779dbcdf-8cb9-4a52-b182-2f17bafaea7d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_cd7b5ce1-9580-4fa6-b14b-2c47a6f933cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_fc67cc64-1be0-4b27-92d1-394ce87d8175" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_779dbcdf-8cb9-4a52-b182-2f17bafaea7d" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_fc67cc64-1be0-4b27-92d1-394ce87d8175" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_d13afaef-8bbf-4920-90e4-26270de31709" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_d13afaef-8bbf-4920-90e4-26270de31709" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_034be27f-47c6-45b4-9762-8fe45b30a471" xlink:href="lgnd-20181231.xsd#lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_034be27f-47c6-45b4-9762-8fe45b30a471" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealizedInvestmentGainsLosses_db028897-3a2a-45c7-8ab0-efbc0f387498" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RealizedInvestmentGainsLosses"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_RealizedInvestmentGainsLosses_db028897-3a2a-45c7-8ab0-efbc0f387498" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_d54b6ada-f65a-46f9-a8e8-333b6685f1b6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_d54b6ada-f65a-46f9-a8e8-333b6685f1b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_4bf77a73-ef87-4b76-bc19-9477d08bb017" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_4bf77a73-ef87-4b76-bc19-9477d08bb017" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_529a5d29-47f6-4baa-bda1-348ceb408177" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_529a5d29-47f6-4baa-bda1-348ceb408177" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_d506a963-87e8-40e6-8e28-9968c5871d71" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_d506a963-87e8-40e6-8e28-9968c5871d71" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_03042cd6-18fa-474e-ae06-36760d1148ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_03042cd6-18fa-474e-ae06-36760d1148ff" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_55307614-30d4-4f8b-ba2a-4d956dc35597" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_ShareBasedCompensation_55307614-30d4-4f8b-ba2a-4d956dc35597" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_d1d2e1ee-2896-4014-bb2e-2ccd14ab3fe8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_d1d2e1ee-2896-4014-bb2e-2ccd14ab3fe8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_81eb895d-c125-4de3-96f3-732d5890f523" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_81eb895d-c125-4de3-96f3-732d5890f523" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_7fdc7484-4769-47f6-93a4-47076d10282e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_7fdc7484-4769-47f6-93a4-47076d10282e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_56d47d8e-0824-4e0c-b9a3-25d127e248b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_56d47d8e-0824-4e0c-b9a3-25d127e248b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c93bd73a-e1af-4025-9185-2c0c2927868b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_c93bd73a-e1af-4025-9185-2c0c2927868b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_7dc6b12c-79e8-4f26-96a7-698df3d2f695" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_7dc6b12c-79e8-4f26-96a7-698df3d2f695" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_bde777ff-c7d2-4f42-bac6-779b8e75aa98" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement"/>
    <link:calculationArc order="16" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_bde777ff-c7d2-4f42-bac6-779b8e75aa98" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseInContingentLiabilities_e49a16a3-e629-4325-a7f1-4fc1f3fa7cc5" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseInContingentLiabilities"/>
    <link:calculationArc order="17" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_lgnd_IncreaseDecreaseInContingentLiabilities_e49a16a3-e629-4325-a7f1-4fc1f3fa7cc5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_0f8190d0-ec0f-46e3-8383-fde484403df2" xlink:href="lgnd-20181231.xsd#lgnd_ChangeInDerivativeAssetAndLiabilityFairValue"/>
    <link:calculationArc order="18" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_0f8190d0-ec0f-46e3-8383-fde484403df2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d6c186e7-d33f-4bf3-bb0e-cee2631a9d21" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="19" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_f93c7bd6-e63c-4a81-b937-bdf5895c01fe" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_d6c186e7-d33f-4bf3-bb0e-cee2631a9d21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_5c08aedf-409d-4088-b9c1-f4471003dd87" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_fc87485c-20c4-497d-ab19-df2cf4a0c4b6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_5c08aedf-409d-4088-b9c1-f4471003dd87" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_fc87485c-20c4-497d-ab19-df2cf4a0c4b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_11a3c9b1-7405-4faf-a145-904ad44ed719" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_5c08aedf-409d-4088-b9c1-f4471003dd87" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_11a3c9b1-7405-4faf-a145-904ad44ed719" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_cd8fa4ef-6402-47a0-848e-0ad25356c251" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_cd8fa4ef-6402-47a0-848e-0ad25356c251" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_75e4e83c-277a-411d-9e10-ff4cf2ecebba" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_75e4e83c-277a-411d-9e10-ff4cf2ecebba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_76494716-f49f-43ad-bd73-07f2b2d0681d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_76494716-f49f-43ad-bd73-07f2b2d0681d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_58bf19e6-5d3d-4cba-8cb3-95d1790e0d54" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_58bf19e6-5d3d-4cba-8cb3-95d1790e0d54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseOfConvertibleBondHedge_24d23834-ecee-48b9-8970-be7f08e858d3" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseOfConvertibleBondHedge"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_lgnd_PurchaseOfConvertibleBondHedge_24d23834-ecee-48b9-8970-be7f08e858d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromHedgeFinancingActivities_e8ce61d1-79ef-4127-8698-7157d8e5ff54" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromHedgeFinancingActivities"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_ProceedsFromHedgeFinancingActivities_e8ce61d1-79ef-4127-8698-7157d8e5ff54" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForHedgeFinancingActivities_a5ad981f-50a3-4c52-8cb3-c90355b24b48" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForHedgeFinancingActivities"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_PaymentsForHedgeFinancingActivities_a5ad981f-50a3-4c52-8cb3-c90355b24b48" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_b51fd6e4-5de9-4f11-9932-1537df954a3a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_b51fd6e4-5de9-4f11-9932-1537df954a3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_a462859d-27f1-493c-a795-7230ea8c5e17" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_a462859d-27f1-493c-a795-7230ea8c5e17" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_e03e22e1-f22c-4fea-81e5-5856d1931260" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_e03e22e1-f22c-4fea-81e5-5856d1931260" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_67762eca-5df9-46db-a9b5-cd2f12efd4b4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_67762eca-5df9-46db-a9b5-cd2f12efd4b4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_c5776dbe-5aaa-4b67-8b0c-5e4177a656f4" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersFinancingActivity"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_f3a7ced3-2456-433c-ad19-9e3bc82afb4b" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_c5776dbe-5aaa-4b67-8b0c-5e4177a656f4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseforCommercialLicenseRights_08bba02a-ef12-494f-9942-62a4303c9653" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseforCommercialLicenseRights"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_lgnd_PurchaseforCommercialLicenseRights_08bba02a-ef12-494f-9942-62a4303c9653" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4bcf2e56-6ef6-43f0-a425-e152bc13d7e7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_4bcf2e56-6ef6-43f0-a425-e152bc13d7e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fc61c8ab-38a2-4a5a-a768-a91f34edd24d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_fc61c8ab-38a2-4a5a-a768-a91f34edd24d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_5f2e3a78-5646-4052-b827-7950e0022b21" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_5f2e3a78-5646-4052-b827-7950e0022b21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_20aa8fc4-fb9b-469c-9ab1-e9ca364719c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_20aa8fc4-fb9b-469c-9ab1-e9ca364719c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_a4723303-431a-4eec-8c0a-88812d331204" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_a4723303-431a-4eec-8c0a-88812d331204" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_f3c068f7-8a20-4064-b3d7-d098834c3a78" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_f3c068f7-8a20-4064-b3d7-d098834c3a78" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_f54f5b90-6c98-4304-9b55-c3f8c4e97ac0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_f54f5b90-6c98-4304-9b55-c3f8c4e97ac0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_2c0fef49-ecb5-4408-a166-056a2dce71b9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_2c0fef49-ecb5-4408-a166-056a2dce71b9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_4885c2ab-9abb-4173-a19f-b9ff6c6f8cf9" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_7245e5dc-cd8c-4c6a-a595-0795ad5ac048" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_4885c2ab-9abb-4173-a19f-b9ff6c6f8cf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_62306d43-6405-4402-b8db-7a3a60d568ac" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2efc57f3-abb4-4806-8574-e0238f9ac413" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_62306d43-6405-4402-b8db-7a3a60d568ac" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_2efc57f3-abb4-4806-8574-e0238f9ac413" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a75a4d28-95aa-43fc-b5a3-f79070a9f875" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_62306d43-6405-4402-b8db-7a3a60d568ac" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a75a4d28-95aa-43fc-b5a3-f79070a9f875" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a242b503-c6cb-4f41-9f00-7e36e18c2332" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_62306d43-6405-4402-b8db-7a3a60d568ac" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_a242b503-c6cb-4f41-9f00-7e36e18c2332" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPolicies"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6b000585-0ac0-4867-88f6-37815de097fb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ed3b9bbd-cfe9-432f-b23c-ec33591d7f97" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6b000585-0ac0-4867-88f6-37815de097fb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_ed3b9bbd-cfe9-432f-b23c-ec33591d7f97" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_106016b4-7d75-495d-a8f7-1bec276e7ad3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet_6b000585-0ac0-4867-88f6-37815de097fb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_106016b4-7d75-495d-a8f7-1bec276e7ad3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_f0584f85-0165-4edf-9db3-16f9f6f128d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_f0584f85-0165-4edf-9db3-16f9f6f128d1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_b68e0343-3719-4db4-9294-7a0bebf913e1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesRestrictedStock"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_b68e0343-3719-4db4-9294-7a0bebf913e1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_8684e161-82fc-44ed-9d52-42791d040cf1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_8684e161-82fc-44ed-9d52-42791d040cf1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6a5fc017-f305-4713-be6a-fc5824d92786" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_6a5fc017-f305-4713-be6a-fc5824d92786" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_7e81d2e4-0e15-412e-84a1-264114700f8a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2beba515-3ce2-4711-b1ac-f42a6a847b07" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_7e81d2e4-0e15-412e-84a1-264114700f8a" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinViking" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinViking"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/InvestmentinViking" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinVikingNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinations"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BusinessCombinations" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_96e102bd-4077-48f1-bce8-3358d0e77c38" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_96e102bd-4077-48f1-bce8-3358d0e77c38" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_cf1e0763-62aa-4d84-b49e-1b80d28f3213" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_cf1e0763-62aa-4d84-b49e-1b80d28f3213" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_ffeb1c2e-3a92-4998-8c24-0e895b6a1486" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_ffeb1c2e-3a92-4998-8c24-0e895b6a1486" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_5130fcf7-0e8c-45ba-9a6e-c69cc9c1cb47" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_5130fcf7-0e8c-45ba-9a6e-c69cc9c1cb47" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_3bcee92a-97dc-4a72-a246-c624cb842e96" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_3bcee92a-97dc-4a72-a246-c624cb842e96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5423f29a-4722-4df6-8e71-7a783214af9e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_Goodwill_5423f29a-4722-4df6-8e71-7a783214af9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_3beea18b-4b6e-42ab-9481-689718593959" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_3beea18b-4b6e-42ab-9481-689718593959" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_ab4078c9-cd46-4d33-a6e6-c9aec35e7963" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_ab4078c9-cd46-4d33-a6e6-c9aec35e7963" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_4e331be7-e646-4aef-afa3-5b19c7a61d2e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_4e331be7-e646-4aef-afa3-5b19c7a61d2e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_d752dcd9-3fcb-4201-87ca-fdf623077657" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_d752dcd9-3fcb-4201-87ca-fdf623077657" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_4cf2da52-f37b-4390-9bde-bce632258b6d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_4cf2da52-f37b-4390-9bde-bce632258b6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_521c9ee5-6cb7-406b-97d9-11fe2c6f65ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_6880e43b-5f93-4482-a839-3642785fece7" xlink:to="loc_us-gaap_RestructuringReserve_521c9ee5-6cb7-406b-97d9-11fe2c6f65ce" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsConsiderationTransferredDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurement"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/FairValueMeasurement" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligations"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/LeaseObligations" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_d0c883f7-028b-4825-aaa6-a9c69fd41198" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_bc8d21d0-db17-4620-a09e-b7baa7216481" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_d0c883f7-028b-4825-aaa6-a9c69fd41198" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_bc8d21d0-db17-4620-a09e-b7baa7216481" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_2e759f61-777e-47fc-b96c-03ff13b86708" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_d0c883f7-028b-4825-aaa6-a9c69fd41198" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_2e759f61-777e-47fc-b96c-03ff13b86708" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_fa4bcb96-cf81-4d65-9ed8-7ed030fa3496" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_a5327dcf-cfbd-435f-ad67-ff9ce68ada96" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_fa4bcb96-cf81-4d65-9ed8-7ed030fa3496" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_a5327dcf-cfbd-435f-ad67-ff9ce68ada96" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_b5bc8fd1-392a-4e3c-9be1-8ff5b91af0fb" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_fa4bcb96-cf81-4d65-9ed8-7ed030fa3496" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_b5bc8fd1-392a-4e3c-9be1-8ff5b91af0fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_952d2556-d124-4ae5-9908-fdc6cf7a3a61" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_fa4bcb96-cf81-4d65-9ed8-7ed030fa3496" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_952d2556-d124-4ae5-9908-fdc6cf7a3a61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_3676e30d-14c1-48f4-81ed-12eed576fc41" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_b6ead69c-e500-4b4b-ab2d-4c5e55dfb552" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_3676e30d-14c1-48f4-81ed-12eed576fc41" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_b6ead69c-e500-4b4b-ab2d-4c5e55dfb552" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_892d09eb-538d-47d7-93e4-948862123134" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_3676e30d-14c1-48f4-81ed-12eed576fc41" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_892d09eb-538d-47d7-93e4-948862123134" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_58211166-1c0e-4427-9529-11189054ef88" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_3676e30d-14c1-48f4-81ed-12eed576fc41" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_58211166-1c0e-4427-9529-11189054ef88" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_977d07ae-3fbf-4876-a59a-0a03b425a982" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_47d522d6-b79c-40f3-97fc-db1993e3d383" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_977d07ae-3fbf-4876-a59a-0a03b425a982" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_47d522d6-b79c-40f3-97fc-db1993e3d383" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_751015d1-7f9a-49ab-86d2-cf299ec72dc2" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_977d07ae-3fbf-4876-a59a-0a03b425a982" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_751015d1-7f9a-49ab-86d2-cf299ec72dc2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_a7d6bee4-5aa3-4b9b-8bd4-d84af8229256" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_e61c84d0-718a-485a-ba06-190b13dd5821" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_a7d6bee4-5aa3-4b9b-8bd4-d84af8229256" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_e61c84d0-718a-485a-ba06-190b13dd5821" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_bbcccdc4-8a14-4152-8a3c-a616d3247e5a" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_a7d6bee4-5aa3-4b9b-8bd4-d84af8229256" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_bbcccdc4-8a14-4152-8a3c-a616d3247e5a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_d3208c63-6273-4e75-a319-38b999a3b539" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_4fe061c1-5fea-47cb-bb3d-254d2dedc551" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_d3208c63-6273-4e75-a319-38b999a3b539" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_4fe061c1-5fea-47cb-bb3d-254d2dedc551" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_e3f2786c-2cb8-43fe-aea9-e5a5c587e621" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_d3208c63-6273-4e75-a319-38b999a3b539" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_e3f2786c-2cb8-43fe-aea9-e5a5c587e621" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotes"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsInvestmentCategoriesDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_404967e2-a868-40d9-ae39-75a492eb8c8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1b6b1c97-bcfe-4eb1-9652-fedf6344c0c9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_404967e2-a868-40d9-ae39-75a492eb8c8d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_1b6b1c97-bcfe-4eb1-9652-fedf6344c0c9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_bc83b78e-6a40-460e-be1c-c0ebd73ea69a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_404967e2-a868-40d9-ae39-75a492eb8c8d" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_bc83b78e-6a40-460e-be1c-c0ebd73ea69a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5cca085e-4dae-489a-9f2c-c2de59ca53e3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_404967e2-a868-40d9-ae39-75a492eb8c8d" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_5cca085e-4dae-489a-9f2c-c2de59ca53e3" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsOtherCurrentAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_79720a54-2ce9-4ea8-af42-09f78d75ad74" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_8c5f2c13-cf2d-43b3-8d72-bd0155490c8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsCurrent_79720a54-2ce9-4ea8-af42-09f78d75ad74" xlink:to="loc_us-gaap_RestrictedCashCurrent_8c5f2c13-cf2d-43b3-8d72-bd0155490c8d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsCurrent_ea65a609-1008-4336-b8cd-eabca9027203" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsCurrent_79720a54-2ce9-4ea8-af42-09f78d75ad74" xlink:to="loc_lgnd_WarrantsCurrent_ea65a609-1008-4336-b8cd-eabca9027203" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherAssetsCurrentOther_445b7379-540c-410d-8c17-de26dd686efe" xlink:href="lgnd-20181231.xsd#lgnd_OtherAssetsCurrentOther"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherAssetsCurrent_79720a54-2ce9-4ea8-af42-09f78d75ad74" xlink:to="loc_lgnd_OtherAssetsCurrentOther_445b7379-540c-410d-8c17-de26dd686efe" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_0f9dbd3e-ca44-4ac4-b675-189850e638e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_4874b04c-55e7-4b94-bb42-3858e2109611" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_0f9dbd3e-ca44-4ac4-b675-189850e638e9" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_4874b04c-55e7-4b94-bb42-3858e2109611" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_5827e412-4dda-4f8a-9a11-7082010f428b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_0f9dbd3e-ca44-4ac4-b675-189850e638e9" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_5827e412-4dda-4f8a-9a11-7082010f428b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ae3843f5-64a1-40a0-89d6-af1c67f36b6d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_dffb0433-8130-4730-96b1-a4d4d4c2d407" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ae3843f5-64a1-40a0-89d6-af1c67f36b6d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_dffb0433-8130-4730-96b1-a4d4d4c2d407" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_fb7f19ef-0ae9-42be-aad1-cb4d7c068b1d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_ae3843f5-64a1-40a0-89d6-af1c67f36b6d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_fb7f19ef-0ae9-42be-aad1-cb4d7c068b1d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsAccruedLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e9dda9e2-da86-4562-9f89-15be77c47d1a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_e9dda9e2-da86-4562-9f89-15be77c47d1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_6ece9579-6803-4158-9431-d1c558883155" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_6ece9579-6803-4158-9431-d1c558883155" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_33eb5846-6f71-497e-8921-2332890b914a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedSalesCommissionCurrentAndNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_33eb5846-6f71-497e-8921-2332890b914a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_764dcde4-f19a-43c9-afae-0b2ccd8ef1da" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedRoyaltiesCurrentAndNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_764dcde4-f19a-43c9-afae-0b2ccd8ef1da" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedStockRepurchases_0cd0d060-e44d-4ec1-b1df-2bb5988ab43b" xlink:href="lgnd-20181231.xsd#lgnd_AccruedStockRepurchases"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_lgnd_AccruedStockRepurchases_0cd0d060-e44d-4ec1-b1df-2bb5988ab43b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedSalesReturns_1c77ae98-4902-4af0-8fc3-1644138ef934" xlink:href="lgnd-20181231.xsd#lgnd_AccruedSalesReturns"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_lgnd_AccruedSalesReturns_1c77ae98-4902-4af0-8fc3-1644138ef934" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_0d1b1e06-08c2-4fb2-bfc8-8ea17d93ebe7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_0d1b1e06-08c2-4fb2-bfc8-8ea17d93ebe7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_2b8bf61a-44dd-44b4-bbc4-17913d06eb93" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_0de81818-3e22-427c-bbaf-5c453a5bd9ca" xlink:to="loc_us-gaap_RestructuringReserveCurrent_2b8bf61a-44dd-44b4-bbc4-17913d06eb93" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsContingentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquity" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquity"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquity" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityShareBasedCompensationDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityStockOptionPlanActivityDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityBreakdownofOptionsOutstandingDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityAssumptionsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityRestrictedStockActivityDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CommitmentsandContingenciesLegalProceedings"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxes"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxes" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_c0e71f4e-15c5-4d70-a1b8-1b567674bc1b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_26938034-c280-44ca-b7bd-89347661fdd6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_c0e71f4e-15c5-4d70-a1b8-1b567674bc1b" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_26938034-c280-44ca-b7bd-89347661fdd6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_033e1e96-0972-4a1e-8974-032601d89aaa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_c0e71f4e-15c5-4d70-a1b8-1b567674bc1b" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_033e1e96-0972-4a1e-8974-032601d89aaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_49e2c533-ebcb-40cd-964e-4091cea48571" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_c0e71f4e-15c5-4d70-a1b8-1b567674bc1b" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_49e2c533-ebcb-40cd-964e-4091cea48571" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_dcd62dbf-d630-4bd5-83cd-1c191bc0f340" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_996575a7-59a3-4350-9540-3eaee235ef7a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_dcd62dbf-d630-4bd5-83cd-1c191bc0f340" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_996575a7-59a3-4350-9540-3eaee235ef7a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_20c3b256-f545-4a66-bb90-be93521f844b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_dcd62dbf-d630-4bd5-83cd-1c191bc0f340" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_20c3b256-f545-4a66-bb90-be93521f844b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_f0798370-6fc1-48ce-b998-f7a027b51236" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_dcd62dbf-d630-4bd5-83cd-1c191bc0f340" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_f0798370-6fc1-48ce-b998-f7a027b51236" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_06111abf-af35-4f08-a07d-765c4001f0b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_dcd62dbf-d630-4bd5-83cd-1c191bc0f340" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_06111abf-af35-4f08-a07d-765c4001f0b7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_de322fa0-e0fa-4db6-a780-b9a1c981a0b2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_de322fa0-e0fa-4db6-a780-b9a1c981a0b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_f7269c31-5760-4827-9b45-7b6497e960bf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_f7269c31-5760-4827-9b45-7b6497e960bf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationContingentValueRights_9f8c51b6-4823-4efe-b840-201c7fe3fa9b" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationContingentValueRights"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_lgnd_IncomeTaxReconciliationContingentValueRights_9f8c51b6-4823-4efe-b840-201c7fe3fa9b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_6c1112e4-37c9-4058-a8fa-24253a41942f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_6c1112e4-37c9-4058-a8fa-24253a41942f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_c42856b5-50e7-4644-bcb8-a66cd0ddb6d7" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_c42856b5-50e7-4644-bcb8-a66cd0ddb6d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_dc2314e4-0e53-4ecb-930d-0a217851fc82" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_dc2314e4-0e53-4ecb-930d-0a217851fc82" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_ba01e475-06b9-4e97-a320-86cbfb8f959b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_ba01e475-06b9-4e97-a320-86cbfb8f959b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_82a8f18e-ec00-406f-ab56-ea16c61f30c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_82a8f18e-ec00-406f-ab56-ea16c61f30c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_35847807-980b-403c-8a33-18a6156d25dd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_35847807-980b-403c-8a33-18a6156d25dd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_f8f00428-a6b5-4b62-9957-a2504617e6fd" xlink:href="lgnd-20181231.xsd#lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_f8f00428-a6b5-4b62-9957-a2504617e6fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther_4038f821-559e-4a70-878b-c4e2f9312d98" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsOther"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit_a94838f2-e462-424e-a425-d39d9b80ef6c" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther_4038f821-559e-4a70-878b-c4e2f9312d98" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesDeferredTaxesDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_d1121807-07d5-4f92-9a70-517db3b48f63" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_d1121807-07d5-4f92-9a70-517db3b48f63" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_c9b24831-bb15-4474-bae9-242e9a3a2577" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_c9b24831-bb15-4474-bae9-242e9a3a2577" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_4f06571c-d8e4-4fae-b9c8-c4b4a7e8c74a" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_4f06571c-d8e4-4fae-b9c8-c4b4a7e8c74a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_fc453fe1-bf6d-4821-88a4-c5a90b27d135" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_fc453fe1-bf6d-4821-88a4-c5a90b27d135" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_06e230cb-24f2-4dfd-8004-034d20418d1a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_06e230cb-24f2-4dfd-8004-034d20418d1a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_1bc7d944-dc9a-4d81-9f90-573cd12f7e95" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsCapitalLossCarryforwards"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_1bc7d944-dc9a-4d81-9f90-573cd12f7e95" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_bd1b5725-0c29-4d10-b46a-7600cc27ef57" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsEquityMethodInvestments"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_bd1b5725-0c29-4d10-b46a-7600cc27ef57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_84674ffa-7071-446c-8ccc-1f9ad3b18a75" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsGross_756aa62a-5df4-4a68-ae12-d64829b96909" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_84674ffa-7071-446c-8ccc-1f9ad3b18a75" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_6ed605d5-3fb1-4cee-8cd8-bace9b90e5be" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_425827f0-ba89-403e-91de-bc1df363ecce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_6ed605d5-3fb1-4cee-8cd8-bace9b90e5be" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_425827f0-ba89-403e-91de-bc1df363ecce" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_85420a66-3d41-4091-8682-70ef39a3e5f3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsNet_6ed605d5-3fb1-4cee-8cd8-bace9b90e5be" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_85420a66-3d41-4091-8682-70ef39a3e5f3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_6016de2a-3461-4a98-ae8a-cc1897a4611d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_e1c7066f-45fb-4e54-a9ac-5066f5981a93" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_6016de2a-3461-4a98-ae8a-cc1897a4611d" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_e1c7066f-45fb-4e54-a9ac-5066f5981a93" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_f5fcad9e-c7aa-40dd-a1da-740cb56e077d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_6016de2a-3461-4a98-ae8a-cc1897a4611d" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_f5fcad9e-c7aa-40dd-a1da-740cb56e077d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_9c763530-0fe5-4d2d-a902-3b2942ccc04d" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFairValueAdjustment"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:to="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_9c763530-0fe5-4d2d-a902-3b2942ccc04d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_741635d9-d3e0-466e-b71e-b6c3c8ea32a4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesFinancingArrangements"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_741635d9-d3e0-466e-b71e-b6c3c8ea32a4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_7898dbf2-440a-4c50-b7f4-7a4c3d05552c" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:to="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_7898dbf2-440a-4c50-b7f4-7a4c3d05552c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_2cc4f4e2-25da-4a9e-b9c9-faa2919478f1" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:to="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_2cc4f4e2-25da-4a9e-b9c9-faa2919478f1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesInvestments_1d346f06-ddfb-41ee-989e-45f632150c10" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesInvestments"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities_57c63d9a-a1a1-4932-b985-95c3ccbd166a" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesInvestments_1d346f06-ddfb-41ee-989e-45f632150c10" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformation"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationTables"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"/>
  <link:calculationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="extended"/>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.DEF
<SEQUENCE>10
<FILENAME>lgnd-20181231_def.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION DEFINITION LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2017 Workiva-->
<!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:xbrldt="http://xbrl.org/2005/xbrldt" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/all" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain"/>
  <link:arcroleRef arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member" xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member"/>
  <link:roleRef roleURI="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#DocumentandEntityInformation"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="extended" id="i83a1648c284346e6a0bc2fb2cda04bf5_08d6e956-5fc5-4800-a42f-cb8c1b00f45b"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended" id="i3ffccf7531524a3aaf2994e09ab359f4_81b793ec-c23a-4dcf-bbf9-764e9efb927d"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended" id="i70a95171fd324edfb48e6ee45927598e_13ae142e-ef1b-4598-a05f-ac8a82ae6fad"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended" id="ie970c6e23acb4fee83a67d546363d24f_a74e41c2-e15a-4e73-8121-2839ca5ce2f8">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:to="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:to="loc_srt_ProductsAndServicesDomain_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:to="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_97fd9271-521f-48ff-b8c2-4efd7717459d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_us-gaap_RoyaltyMember_97fd9271-521f-48ff-b8c2-4efd7717459d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaterialSalesCaptisolMember_1eeb8e3f-af69-4085-a90a-530b1378e090" xlink:href="lgnd-20181231.xsd#lgnd_MaterialSalesCaptisolMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_lgnd_MaterialSalesCaptisolMember_1eeb8e3f-af69-4085-a90a-530b1378e090" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_df0778ff-628b-4fbe-8eef-46d3b4a9915d" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesandProductOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_df0778ff-628b-4fbe-8eef-46d3b4a9915d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3065c35b-8bc6-4fd9-8e30-b457f02757ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3065c35b-8bc6-4fd9-8e30-b457f02757ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpensesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_0820c8cf-0ddc-4039-a7aa-2a8932f50dc5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_0820c8cf-0ddc-4039-a7aa-2a8932f50dc5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_1d161703-5c47-420a-b607-28f760bfd152" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSoldAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_1d161703-5c47-420a-b607-28f760bfd152" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_fefcdf23-e73c-4aca-b35d-4f849fdc6294" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_fefcdf23-e73c-4aca-b35d-4f849fdc6294" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_dd3bb6d0-6a62-4208-bd07-946fc0808f72" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_dd3bb6d0-6a62-4208-bd07-946fc0808f72" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_25ef6164-501f-4502-ac52-7585ac430269" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_25ef6164-501f-4502-ac52-7585ac430269" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_c16b6e44-489c-41c7-90fa-e5bc9f8dccb9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OperatingIncomeLoss_c16b6e44-489c-41c7-90fa-e5bc9f8dccb9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_fa6d7c3e-852a-430d-af6b-e91d3fa4b2bc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_fa6d7c3e-852a-430d-af6b-e91d3fa4b2bc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_c9e932f8-abdb-4612-8a00-98c67e7dae0a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeNonoperating"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_c9e932f8-abdb-4612-8a00-98c67e7dae0a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_9c249e49-1b52-4df7-a41b-77f2103942cf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_InterestExpense_9c249e49-1b52-4df7-a41b-77f2103942cf" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_c4cc1b15-20b0-42fb-8329-8165a641e662" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_c4cc1b15-20b0-42fb-8329-8165a641e662" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_ded709e0-d299-43a4-b3bb-5bce41d18ed2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_ded709e0-d299-43a4-b3bb-5bce41d18ed2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_aef0ba80-1cac-4a46-bb61-4d098b05d8a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_aef0ba80-1cac-4a46-bb61-4d098b05d8a3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_82e56b54-146b-4afb-8422-bf9de1f4246f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_82e56b54-146b-4afb-8422-bf9de1f4246f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_72758937-63d6-4128-b128-8326f2f7f4b2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_72758937-63d6-4128-b128-8326f2f7f4b2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_ba40df40-871f-4a34-a824-9ff287fc6fcc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_ba40df40-871f-4a34-a824-9ff287fc6fcc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_99800c27-8376-456b-82b1-b880923892ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_99800c27-8376-456b-82b1-b880923892ef" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_f40c13b2-8c5f-488c-b709-0849d1e20e69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_f40c13b2-8c5f-488c-b709-0849d1e20e69" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8c56e3ef-68d5-4052-8bb9-c65a02cbe1d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_NetIncomeLoss_8c56e3ef-68d5-4052-8bb9-c65a02cbe1d9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_99e494a2-ea26-4005-b3e8-6699bab614b1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_99e494a2-ea26-4005-b3e8-6699bab614b1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_0bf267f7-3c6d-4de9-9dfd-8c2f2390b174" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_0bf267f7-3c6d-4de9-9dfd-8c2f2390b174" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_2789148d-6a2a-4875-807e-f532069798f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_EarningsPerShareBasic_2789148d-6a2a-4875-807e-f532069798f4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_616f908b-dfc3-4f4c-90ce-4d43cfd3f0aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_616f908b-dfc3-4f4c-90ce-4d43cfd3f0aa" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_ae345b3e-d0de-44af-b579-ffa471a30a3f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_ae345b3e-d0de-44af-b579-ffa471a30a3f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_2cb2f160-876c-4445-a132-f8f78edd422e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_EarningsPerShareDiluted_2cb2f160-876c-4445-a132-f8f78edd422e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_75289b1d-9e73-41fc-9264-b5dc015c1450" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_75289b1d-9e73-41fc-9264-b5dc015c1450" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e7a55070-f6d8-45a2-98c8-466b97080492" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e7a55070-f6d8-45a2-98c8-466b97080492" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended" id="i1898fe41adea47ec86054eabb9dcfb71_c5e9de96-d3cb-446c-a9f7-a97b6bcba8b6"/>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="extended" id="ida56a3cb1a4e48c184ad9a1867903f8e_184da86f-009d-45c1-aba8-0feaf19e9531">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:to="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f75100fb-70c3-4d30-9b69-7a1727435806_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:to="loc_us-gaap_EquityComponentDomain_f75100fb-70c3-4d30-9b69-7a1727435806_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:to="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_3321fcb5-3753-448c-b544-2935e21caac9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_CommonStockMember_3321fcb5-3753-448c-b544-2935e21caac9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_e5c637b9-d5a7-49cc-bdba-17754794eafd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_e5c637b9-d5a7-49cc-bdba-17754794eafd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_14894e93-afc8-4b61-9d9b-f16c21498cfc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_14894e93-afc8-4b61-9d9b-f16c21498cfc" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_00f9714c-f20d-4f04-91ff-b443323e83ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_RetainedEarningsMember_00f9714c-f20d-4f04-91ff-b443323e83ed" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:to="loc_us-gaap_TypeOfAdoptionMember_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201609Member_6cca0897-4a5f-4a94-a75a-bc8f3c1c93a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201609Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201609Member_6cca0897-4a5f-4a94-a75a-bc8f3c1c93a0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_91241eea-4cad-47cf-86dd-119a4285a5ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_91241eea-4cad-47cf-86dd-119a4285a5ec" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_2d7fb536-9d4e-45be-b4c4-fe821d8a4403" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_2d7fb536-9d4e-45be-b4c4-fe821d8a4403" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_8db9ff5a-6a9f-49ee-bd71-b953aa800a61_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_8db9ff5a-6a9f-49ee-bd71-b953aa800a61_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_fe51a561-b9a1-4cd9-a802-3a1182ecd29d" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_fe51a561-b9a1-4cd9-a802-3a1182ecd29d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_50d5fc12-5354-45c0-8f45-86cb795e0c62" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_50d5fc12-5354-45c0-8f45-86cb795e0c62" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_28f79867-b9af-4f24-89ec-d74419b15f85" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_SharesOutstanding_28f79867-b9af-4f24-89ec-d74419b15f85" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d60db225-2983-4213-810b-2b41bc0bf583" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d60db225-2983-4213-810b-2b41bc0bf583" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_c40f11db-2d6a-419b-b044-693f9d7629ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_c40f11db-2d6a-419b-b044-693f9d7629ef" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_7119d87b-f931-42e1-9a06-6840b989be67" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_7119d87b-f931-42e1-9a06-6840b989be67" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_a9a9a7b6-c331-4972-a159-180b09b6cac0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_a9a9a7b6-c331-4972-a159-180b09b6cac0" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3036073c-e79b-4ee2-b8c4-c4d56279fabd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3036073c-e79b-4ee2-b8c4-c4d56279fabd" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_1ef9df53-8e5e-45f7-ad2a-aa733d14c0cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_1ef9df53-8e5e-45f7-ad2a-aa733d14c0cd" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_3d456c73-d5fa-4cf7-8839-7615e9923692" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_3d456c73-d5fa-4cf7-8839-7615e9923692" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_1b468c1b-b97f-4f01-a838-27c08e6d800a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_1b468c1b-b97f-4f01-a838-27c08e6d800a" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_a4f2fc0f-7a2f-412a-8a9d-02703cac4439" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_a4f2fc0f-7a2f-412a-8a9d-02703cac4439" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5006ae87-a56d-49b0-85c5-4ab0da01207a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5006ae87-a56d-49b0-85c5-4ab0da01207a" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_921f48af-ec11-4dc1-9880-8081eb5b2b98" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_921f48af-ec11-4dc1-9880-8081eb5b2b98" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_4ccf0c34-8538-4d83-8590-1a918f8991c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_4ccf0c34-8538-4d83-8590-1a918f8991c1" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_e7a58819-d9e5-4368-8aa2-09a64ceffd06" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_e7a58819-d9e5-4368-8aa2-09a64ceffd06" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_393a233f-9944-469d-ac0e-51a0a32f6837" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_393a233f-9944-469d-ac0e-51a0a32f6837" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_14df8df8-bfd7-4f18-af21-910a3f556a76" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_14df8df8-bfd7-4f18-af21-910a3f556a76" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_5f2c3109-0ee6-4335-87f8-60f32de24bd4" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_5f2c3109-0ee6-4335-87f8-60f32de24bd4" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_fd320de5-c8df-4058-bc0a-bf874c5a1e55" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_fd320de5-c8df-4058-bc0a-bf874c5a1e55" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_1709c44f-d4d0-4116-a5ca-f2664b89a67d" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_1709c44f-d4d0-4116-a5ca-f2664b89a67d" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_8cb67c19-b90b-43b4-b73b-1557bde4f772" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_8cb67c19-b90b-43b4-b73b-1557bde4f772" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2ba94884-aaff-4ca0-b7a7-cc46c95e40cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_NetIncomeLoss_2ba94884-aaff-4ca0-b7a7-cc46c95e40cd" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_deec1cba-a26a-477d-b3c6-76e319930590" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d80d5f88-93fb-4fb1-a675-c1eaee39db0e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended" id="i1f2e5e3de1714eb9ae974c8f6e6ab839_95cd7ce3-6fe3-4843-9242-27ef1b4518cd">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_25b0f748-e612-411e-a8b4-00b8bdea2959_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_25b0f748-e612-411e-a8b4-00b8bdea2959_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_c7715d0f-b785-40ef-9ee3-9c8b66566e47" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_c7715d0f-b785-40ef-9ee3-9c8b66566e47" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseofCommonStockMember_9e4c2956-c328-4ffb-8f59-c5f173b188c2" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseofCommonStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:to="loc_lgnd_PurchaseofCommonStockMember_9e4c2956-c328-4ffb-8f59-c5f173b188c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_d97ae0a4-9b8a-4125-9c16-bc271fe5d3a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_ProfitLoss_d97ae0a4-9b8a-4125-9c16-bc271fe5d3a3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_833fbb53-8dc0-41c3-876f-1e60206d1ff3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_833fbb53-8dc0-41c3-876f-1e60206d1ff3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_3854f92d-9ada-4085-8d1f-e9757ea55d9e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_3854f92d-9ada-4085-8d1f-e9757ea55d9e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_c335d135-af90-4c4e-a4f2-4676aca79612" xlink:href="lgnd-20181231.xsd#lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_c335d135-af90-4c4e-a4f2-4676aca79612" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealizedInvestmentGainsLosses_62f6a255-b7e3-45fd-96b5-ab79c5f04c35" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RealizedInvestmentGainsLosses"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_RealizedInvestmentGainsLosses_62f6a255-b7e3-45fd-96b5-ab79c5f04c35" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_e2b4f818-f3c0-4e55-a63b-ab535617b511" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_e2b4f818-f3c0-4e55-a63b-ab535617b511" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_bd7d22ee-16f4-4ee9-ba38-febd7acc598c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_bd7d22ee-16f4-4ee9-ba38-febd7acc598c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_8e28f8dd-fc5a-408d-8fc8-fd476396fa0b" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_8e28f8dd-fc5a-408d-8fc8-fd476396fa0b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f7a57af-d9ac-4921-a878-8db2f4292b32" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f7a57af-d9ac-4921-a878-8db2f4292b32" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_42b2f593-8c18-4a43-8dbf-e9c981967448" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_42b2f593-8c18-4a43-8dbf-e9c981967448" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_924fcd89-8835-49ca-a377-985ef78a54bf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_ShareBasedCompensation_924fcd89-8835-49ca-a377-985ef78a54bf" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_214e6219-67f6-4fbc-b8a2-d3d16d9e2b82" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_214e6219-67f6-4fbc-b8a2-d3d16d9e2b82" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_a11fe548-7b6f-4152-85c3-b8fd65de7547" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_a11fe548-7b6f-4152-85c3-b8fd65de7547" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_1ab29f5e-ff54-4827-bed2-de8e584540b6" xlink:href="lgnd-20181231.xsd#lgnd_ChangeInDerivativeAssetAndLiabilityFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_1ab29f5e-ff54-4827-bed2-de8e584540b6" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_07e40a48-bcab-448a-aad2-58a44730de27" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_07e40a48-bcab-448a-aad2-58a44730de27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_343ea534-f838-4c52-9f3a-7c667fdfbbe2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_343ea534-f838-4c52-9f3a-7c667fdfbbe2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_2bf64ae2-3b13-4432-8b02-7d859f812990" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_2bf64ae2-3b13-4432-8b02-7d859f812990" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_682065d8-f55b-4b94-8948-83ab4294776c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_682065d8-f55b-4b94-8948-83ab4294776c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_231bb1c5-7880-41c3-b905-17ed18450eea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_231bb1c5-7880-41c3-b905-17ed18450eea" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseInContingentLiabilities_19aa579d-b3c9-461a-aeff-d40ca9e466ab" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseInContingentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_lgnd_IncreaseDecreaseInContingentLiabilities_19aa579d-b3c9-461a-aeff-d40ca9e466ab" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4a5af3f7-2419-474c-baad-e3c36c67f485" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4a5af3f7-2419-474c-baad-e3c36c67f485" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_05578e82-f256-401b-9dfb-f3a351007f96" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_05578e82-f256-401b-9dfb-f3a351007f96" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseforCommercialLicenseRights_23fa1b8a-914d-47e8-aa08-00239783f836" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseforCommercialLicenseRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_lgnd_PurchaseforCommercialLicenseRights_23fa1b8a-914d-47e8-aa08-00239783f836" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a8c39e83-2b16-436b-8015-ab1ac585798a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a8c39e83-2b16-436b-8015-ab1ac585798a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_9c702e74-7bcc-43d2-8c8d-444876e6048d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_9c702e74-7bcc-43d2-8c8d-444876e6048d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_1c35a2ba-f2c1-454f-aaf8-1b9ded9f670e" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_1c35a2ba-f2c1-454f-aaf8-1b9ded9f670e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5c922e28-2068-44a6-9b43-26872051045c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5c922e28-2068-44a6-9b43-26872051045c" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_37f49a79-6276-478f-abe0-6faf0cc1ad3a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_37f49a79-6276-478f-abe0-6faf0cc1ad3a" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_ac020555-5f9e-4ad9-9d9c-ceab0b2fdf09" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_ac020555-5f9e-4ad9-9d9c-ceab0b2fdf09" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_1104af8a-2c3c-4530-b349-63cff5dcde00" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_1104af8a-2c3c-4530-b349-63cff5dcde00" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_e5c216db-0c12-4029-9d06-10fc9db76d05" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_e5c216db-0c12-4029-9d06-10fc9db76d05" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_73f1703c-e316-406f-b7ee-d0b2a2581fcc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_73f1703c-e316-406f-b7ee-d0b2a2581fcc" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8e59cc10-d6cc-415d-bbb9-62f6d3fa1d03" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8e59cc10-d6cc-415d-bbb9-62f6d3fa1d03" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_da66aa69-b81f-4d47-98f9-dc1655a0d2ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_da66aa69-b81f-4d47-98f9-dc1655a0d2ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_fdf3c997-d850-4e49-a168-53b673d56dde" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_fdf3c997-d850-4e49-a168-53b673d56dde" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_390dd1c1-0dff-486a-8489-c3f6130db812" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_390dd1c1-0dff-486a-8489-c3f6130db812" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_918b99f2-ac58-4e59-be2a-c30e4e0c5f8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_918b99f2-ac58-4e59-be2a-c30e4e0c5f8d" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseOfConvertibleBondHedge_f1e25b4b-7fe2-4d9d-98ff-5a592bee2e45" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseOfConvertibleBondHedge"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_lgnd_PurchaseOfConvertibleBondHedge_f1e25b4b-7fe2-4d9d-98ff-5a592bee2e45" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromHedgeFinancingActivities_66e77b5e-6b00-4236-98ad-080cff541722" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromHedgeFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromHedgeFinancingActivities_66e77b5e-6b00-4236-98ad-080cff541722" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForHedgeFinancingActivities_bc03113b-db3c-4c90-b924-b79147b82d8c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForHedgeFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForHedgeFinancingActivities_bc03113b-db3c-4c90-b924-b79147b82d8c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_05389ad4-e28c-4448-8343-4421afdc9ae0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_05389ad4-e28c-4448-8343-4421afdc9ae0" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_736c5daa-f23e-4cc9-a26f-28e111432f5e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_736c5daa-f23e-4cc9-a26f-28e111432f5e" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3128d0e2-a4f3-4702-98c2-392cbccd0b66" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3128d0e2-a4f3-4702-98c2-392cbccd0b66" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_da4c2a38-55ee-4a15-99cf-2593d73c8a1b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_da4c2a38-55ee-4a15-99cf-2593d73c8a1b" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_58979788-3edb-440d-8631-b892cf08c365" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersFinancingActivity"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_58979788-3edb-440d-8631-b892cf08c365" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fd39ef16-5921-4308-b48e-b099437cd8fe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fd39ef16-5921-4308-b48e-b099437cd8fe" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0f681fe4-940c-40a5-b0e3-05056f36ce4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0f681fe4-940c-40a5-b0e3-05056f36ce4c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_71ea98b9-ad23-423a-be0f-1dff0866a13a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_71ea98b9-ad23-423a-be0f-1dff0866a13a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6a6877e3-c4bd-403c-b821-d5c50942b135" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6a6877e3-c4bd-403c-b821-d5c50942b135" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ec3a1352-b48b-4ccb-8c8b-48bf5e30a881" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_fbe54367-72ff-4044-8125-61b910319fd9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:to="loc_us-gaap_InterestPaidNet_fbe54367-72ff-4044-8125-61b910319fd9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaid_1695c83b-b5ed-4d87-8ba7-ddaf46627dd0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaid"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:to="loc_us-gaap_IncomeTaxesPaid_1695c83b-b5ed-4d87-8ba7-ddaf46627dd0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3035566e-4b93-4161-81f6-90805ae7c153" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3035566e-4b93-4161-81f6-90805ae7c153" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable_9cd2a4b9-5592-46b4-b27e-a26699a59bed" xlink:href="lgnd-20181231.xsd#lgnd_EquityReceivedinRepaymentofNoteReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable_9cd2a4b9-5592-46b4-b27e-a26699a59bed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedInventoryPurchases_c9543b9d-8c2b-4869-99f3-6563b8db7f85" xlink:href="lgnd-20181231.xsd#lgnd_AccruedInventoryPurchases"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_lgnd_AccruedInventoryPurchases_c9543b9d-8c2b-4869-99f3-6563b8db7f85" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_f39825f8-4516-4d68-90fd-baa3aeb549d5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_f39825f8-4516-4d68-90fd-baa3aeb549d5" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPolicies"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="extended" id="i9cd9a3d42a4444d19e466a29ebd8b1d2_af165903-d5a8-44fd-a07a-a5a0c766fa7c"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended" id="ie28419d0bc4c42d9a58d1e940b6075c0_5bc62e67-5d99-4a19-8da8-14a5be9b8ab1"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended" id="i45c1776704ee4a84970d9f6a1f463253_4bda8dfa-7273-4dbf-8e5c-185dc5e280e7"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended" id="i162d3ba8448643a0b3a754060374236e_6bd2833c-eeb4-4528-9544-01699ffb40a5">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_a335052e-cedc-4d34-8949-1a142151b3e6_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:to="loc_srt_ProductsAndServicesDomain_a335052e-cedc-4d34-8949-1a142151b3e6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:to="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:to="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyPromactaMember_1345cbe1-f8fc-482d-bfbc-d6e030676ac5" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyPromactaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyPromactaMember_1345cbe1-f8fc-482d-bfbc-d6e030676ac5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyKyprolisMember_f91eabb1-2b9e-49dd-b8c5-d1f0e3fc04a9" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyKyprolisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyKyprolisMember_f91eabb1-2b9e-49dd-b8c5-d1f0e3fc04a9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyEvomelaMember_9674d3ae-3e07-4cd4-a642-a1e607c65830" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyEvomelaMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyEvomelaMember_9674d3ae-3e07-4cd4-a642-a1e607c65830" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyOtherMember_5400b880-7b44-4762-aa5b-4f2993439a0b" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyOtherMember_5400b880-7b44-4762-aa5b-4f2993439a0b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_0b964d13-4d40-4a35-a50b-599acdd93b57_default" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:to="loc_dei_EntityDomain_0b964d13-4d40-4a35-a50b-599acdd93b57_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:to="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_8c00f435-8afa-4895-a640-06b66228d77d" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_8c00f435-8afa-4895-a640-06b66228d77d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectorMember_2cadb826-93e5-4ce4-a07a-e2f876ef9907" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:to="loc_us-gaap_DirectorMember_2cadb826-93e5-4ce4-a07a-e2f876ef9907" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_6c47967b-c984-4a26-b1ad-7169f6d101dd_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_6c47967b-c984-4a26-b1ad-7169f6d101dd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_fd10eae2-508c-4502-852f-021124c3c344" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_fd10eae2-508c-4502-852f-021124c3c344" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_18eeb0fe-385d-4947-a6e0-02bcd1bc857a_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_18eeb0fe-385d-4947-a6e0-02bcd1bc857a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_29965567-c702-4c7e-8ade-b4ea54d8a865" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_29965567-c702-4c7e-8ade-b4ea54d8a865" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_57b87a1b-59ae-4f91-84bd-e0272698e2a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:to="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_57b87a1b-59ae-4f91-84bd-e0272698e2a3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:to="loc_us-gaap_EquityComponentDomain_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:to="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_f55dc4e3-6d17-483e-a884-25966ca78438" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_f55dc4e3-6d17-483e-a884-25966ca78438" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_131947d0-04e8-4881-9a5f-0f60358fe544" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:to="loc_us-gaap_RetainedEarningsMember_131947d0-04e8-4881-9a5f-0f60358fe544" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_401d13e1-d98a-4041-b0db-f410d880290b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:to="loc_us-gaap_TypeOfAdoptionMember_401d13e1-d98a-4041-b0db-f410d880290b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:to="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201609Member_64e77efa-098f-406f-8262-969d48a7ffc7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201609Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201609Member_64e77efa-098f-406f-8262-969d48a7ffc7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_7dfd35ae-3b81-4617-b3fb-0497b31ff8f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_7dfd35ae-3b81-4617-b3fb-0497b31ff8f4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_abaf188e-a238-4837-bc78-ed2d7999dada" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_abaf188e-a238-4837-bc78-ed2d7999dada" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201615Member_d55ff6e9-682a-41ad-826c-c05ba3de767c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201615Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201615Member_d55ff6e9-682a-41ad-826c-c05ba3de767c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_aed705e8-9366-47fc-82c4-0175d0290ce7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_aed705e8-9366-47fc-82c4-0175d0290ce7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_63a0c148-5558-4d0a-89a8-3b7ac017d3ac" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_63a0c148-5558-4d0a-89a8-3b7ac017d3ac" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_79ece950-870c-4737-a3cd-81903a15e3fb" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_79ece950-870c-4737-a3cd-81903a15e3fb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_b3281673-4f60-4335-b2b7-a546151627c0_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_b3281673-4f60-4335-b2b7-a546151627c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_6dc9b4c1-e138-4d56-82ce-f439da1daa30" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:to="loc_us-gaap_SeniorNotesMember_6dc9b4c1-e138-4d56-82ce-f439da1daa30" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bcc5ea99-f65c-4e71-9443-f716c76a27f5_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_bcc5ea99-f65c-4e71-9443-f716c76a27f5_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_6b66cfb8-6617-487b-82b8-08c2f03b3f2d" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_6b66cfb8-6617-487b-82b8-08c2f03b3f2d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoMember_29c5e06b-ce2f-4fe9-8b3a-6422851f7c57" xlink:href="lgnd-20181231.xsd#lgnd_AziyoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_AziyoMember_29c5e06b-ce2f-4fe9-8b3a-6422851f7c57" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorMatrixMember_fed23aa7-b02c-46f6-87fa-5e9ca17fb7f4" xlink:href="lgnd-20181231.xsd#lgnd_CorMatrixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_CorMatrixMember_fed23aa7-b02c-46f6-87fa-5e9ca17fb7f4" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2b2971a3-101e-4072-b236-19c6c89f8ee8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_2b2971a3-101e-4072-b236-19c6c89f8ee8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyAgreementsMember_0ea7d3b6-f01f-40ef-ac64-d0cba36e3d04" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:to="loc_us-gaap_RoyaltyAgreementsMember_0ea7d3b6-f01f-40ef-ac64-d0cba36e3d04" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_e12eced0-48ed-4e81-9b24-d8137960d242" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:to="loc_us-gaap_LicensingAgreementsMember_e12eced0-48ed-4e81-9b24-d8137960d242" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b19f29bc-0532-4ddf-9921-ce66688ada5b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_b19f29bc-0532-4ddf-9921-ce66688ada5b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_3bd38d7a-689a-47f3-8039-77f74fe76d5c" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:to="loc_lgnd_CrystalMember_3bd38d7a-689a-47f3-8039-77f74fe76d5c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MetabasisTherapeuticsMember_0025baea-d8c5-4c62-a53d-a810a969146a" xlink:href="lgnd-20181231.xsd#lgnd_MetabasisTherapeuticsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:to="loc_lgnd_MetabasisTherapeuticsMember_0025baea-d8c5-4c62-a53d-a810a969146a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:to="loc_srt_RangeMember_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:to="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_4cc14076-fe0a-4377-b21d-d524bdfe3ca2" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:to="loc_srt_MinimumMember_4cc14076-fe0a-4377-b21d-d524bdfe3ca2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_56e0e662-2130-46c8-9b94-aeff88a020b6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:to="loc_srt_MaximumMember_56e0e662-2130-46c8-9b94-aeff88a020b6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6fc9ad50-ab54-4713-a392-9fb9bf078641_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6fc9ad50-ab54-4713-a392-9fb9bf078641_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_84c5f208-fbfb-4a2a-95f8-8c2ccfefd73b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:to="loc_us-gaap_EmployeeStockOptionMember_84c5f208-fbfb-4a2a-95f8-8c2ccfefd73b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_34bd3196-babc-4ec7-8961-bccc662b1cee_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:to="loc_us-gaap_VestingDomain_34bd3196-babc-4ec7-8961-bccc662b1cee_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:to="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodOneMember_3386c510-1a13-4d83-85d9-90d9fb795efc" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:to="loc_lgnd_VestingPeriodOneMember_3386c510-1a13-4d83-85d9-90d9fb795efc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodTwoMember_2137976b-5fb6-401a-8323-ff7432a76a0f" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:to="loc_lgnd_VestingPeriodTwoMember_2137976b-5fb6-401a-8323-ff7432a76a0f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:to="loc_us-gaap_PlanNameDomain_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:to="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_ad474feb-9a83-4981-a8a8-56c0feead349" xlink:href="lgnd-20181231.xsd#lgnd_TwoThousandTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:to="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_ad474feb-9a83-4981-a8a8-56c0feead349" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_17e3ba77-f8bf-48dc-b42c-3fd75a5acd36" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_17e3ba77-f8bf-48dc-b42c-3fd75a5acd36" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_99849427-f664-42fb-ba20-c4386144b4cf" xlink:href="lgnd-20181231.xsd#lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_99849427-f664-42fb-ba20-c4386144b4cf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_1e047b12-b91e-4df0-bba1-f7a1e63a059c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWriteDown"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_InventoryWriteDown_1e047b12-b91e-4df0-bba1-f7a1e63a059c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3ed1d4d8-e94d-442a-be17-d851f933955b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3ed1d4d8-e94d-442a-be17-d851f933955b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_c3014c99-c2e5-491f-8134-f50b58c95032" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_c3014c99-c2e5-491f-8134-f50b58c95032" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberOfContingentValueRightsIssued_9016522d-6251-4c5e-8401-eb5fcf059116" xlink:href="lgnd-20181231.xsd#lgnd_NumberOfContingentValueRightsIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_NumberOfContingentValueRightsIssued_9016522d-6251-4c5e-8401-eb5fcf059116" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_43c882e9-f5ad-4704-8090-46ca567ed755" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_43c882e9-f5ad-4704-8090-46ca567ed755" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ProductRoyaltyPercentage_4fb9a216-ec6e-4fb2-a0cf-ad3b3cd307d5" xlink:href="lgnd-20181231.xsd#lgnd_ProductRoyaltyPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ProductRoyaltyPercentage_4fb9a216-ec6e-4fb2-a0cf-ad3b3cd307d5" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OwnershipInEntityByDirectorPercentage_6c1d9392-94f3-4a2f-98be-23af8b2b8508" xlink:href="lgnd-20181231.xsd#lgnd_OwnershipInEntityByDirectorPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_OwnershipInEntityByDirectorPercentage_6c1d9392-94f3-4a2f-98be-23af8b2b8508" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_8cb23e45-545a-425b-bef5-f4c18bc9f868" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_8cb23e45-545a-425b-bef5-f4c18bc9f868" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyAgreementExpirationPeriod_17490822-9a05-4333-85bf-c67ea8457594" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyAgreementExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RoyaltyAgreementExpirationPeriod_17490822-9a05-4333-85bf-c67ea8457594" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_1ab5cce9-91ec-42a9-b84f-baf0257bb65d" xlink:href="lgnd-20181231.xsd#lgnd_ForecastedCashFlowsEffectiveInterestRatePercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_1ab5cce9-91ec-42a9-b84f-baf0257bb65d" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2588247d-7f28-484a-b514-f0cff0b2b0d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2588247d-7f28-484a-b514-f0cff0b2b0d9" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_5fedad05-e946-4f13-8c4a-b2fa1ffd7a69" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_5fedad05-e946-4f13-8c4a-b2fa1ffd7a69" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_207ac468-40db-4a95-bdf0-6d39226555f5" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_207ac468-40db-4a95-bdf0-6d39226555f5" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_5d7f036e-40f3-4ab1-b25f-911ab54139e2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_5d7f036e-40f3-4ab1-b25f-911ab54139e2" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e83973b4-c6ee-4f33-87ef-c18a7a0c01dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e83973b4-c6ee-4f33-87ef-c18a7a0c01dc" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2c4af02b-8f7c-4f2a-852b-023ee64b2431" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetIncomeLoss_2c4af02b-8f7c-4f2a-852b-023ee64b2431" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_13c9d5d7-56da-4642-a359-d0788dbdb8d2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_EarningsPerShareDiluted_13c9d5d7-56da-4642-a359-d0788dbdb8d2" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput_0e1e2d57-2fe0-4d45-b60c-e646b967fb94" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput_0e1e2d57-2fe0-4d45-b60c-e646b967fb94" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_6bb2a7c6-bc46-494e-ba10-ae065fb5191e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_6bb2a7c6-bc46-494e-ba10-ae065fb5191e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_86bfb56e-d4e3-4278-ab87-30ff85821e3e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_86bfb56e-d4e3-4278-ab87-30ff85821e3e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_0015afb1-d2f3-4ffb-91cb-c4663c3d1f33" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_0015afb1-d2f3-4ffb-91cb-c4663c3d1f33" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_4756940c-8021-4016-85b2-bb885562a9c3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_4756940c-8021-4016-85b2-bb885562a9c3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_dfcdfa17-30ea-415f-a8ca-74d8f83be897" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_dfcdfa17-30ea-415f-a8ca-74d8f83be897" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_70b1aa65-c69b-4eb5-8f07-dddd4262b874" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_70b1aa65-c69b-4eb5-8f07-dddd4262b874" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_8651c0c3-4376-455d-b15c-facee87fb43d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_8651c0c3-4376-455d-b15c-facee87fb43d" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c2961147-03b6-46f1-8206-3fc6455fa8b3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c2961147-03b6-46f1-8206-3fc6455fa8b3" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_a74d8afb-6e5a-43ce-9cf0-543e599c97e2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_a74d8afb-6e5a-43ce-9cf0-543e599c97e2" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_eda4f340-1732-48a0-9f33-e319d7892aaf" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdBusinessDaysforRepaymentofPrincipal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_eda4f340-1732-48a0-9f33-e319d7892aaf" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_25012d8b-65cd-409e-90bb-6a1e7dfce14e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_25012d8b-65cd-409e-90bb-6a1e7dfce14e" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_4afe05db-a47a-4f92-99a4-397d18d11e99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_4afe05db-a47a-4f92-99a4-397d18d11e99" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_78de276e-96a3-429a-9db3-3837433d3b51" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_78de276e-96a3-429a-9db3-3837433d3b51" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8246f845-9782-4e75-ad46-1fd7ee1073e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8246f845-9782-4e75-ad46-1fd7ee1073e9" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe113c30-04e5-4277-8290-889402d9c7c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe113c30-04e5-4277-8290-889402d9c7c0" xlink:type="arc" order="31"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="extended" id="ic12c4fff22bd408886d494de545bea67_f3681ea5-4bec-4dff-89d9-b4d0202056a1">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:to="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_3a72fd73-1821-4caa-a38b-5bba94e42254_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_3a72fd73-1821-4caa-a38b-5bba94e42254_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_4745ad59-b978-4279-9d4e-e73696910fb8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_4745ad59-b978-4279-9d4e-e73696910fb8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a214cab9-703d-44c2-8fbb-826cc26f003d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_a214cab9-703d-44c2-8fbb-826cc26f003d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_4ae39076-b68a-4c5d-a880-037c4ec1ce18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:to="loc_us-gaap_SalesRevenueNetMember_4ae39076-b68a-4c5d-a880-037c4ec1ce18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_5a87b9d8-f7bf-4256-9fab-b09212f85835_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:to="loc_srt_NameOfMajorCustomerDomain_5a87b9d8-f7bf-4256-9fab-b09212f85835_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:to="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerAMember_67fc7f0f-1457-4da5-aaf6-36bac9e23ffe" xlink:href="lgnd-20181231.xsd#lgnd_PartnerAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerAMember_67fc7f0f-1457-4da5-aaf6-36bac9e23ffe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerBMember_334e1b5a-2dab-471f-a0ad-e6a0fab11c8b" xlink:href="lgnd-20181231.xsd#lgnd_PartnerBMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerBMember_334e1b5a-2dab-471f-a0ad-e6a0fab11c8b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerCMember_ff52b44b-a170-49a5-a783-8f79f74122f1" xlink:href="lgnd-20181231.xsd#lgnd_PartnerCMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerCMember_ff52b44b-a170-49a5-a783-8f79f74122f1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_fe6dac08-39f8-423f-9a53-3883b78ddef2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_fe6dac08-39f8-423f-9a53-3883b78ddef2" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="extended" id="icd22df1623eb4d3282639752a742742d_cad3fee0-d337-460d-8a11-bdbb5541befe">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:to="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7852063b-9377-4d40-8498-10bc01e1c827_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:to="loc_srt_ProductsAndServicesDomain_7852063b-9377-4d40-8498-10bc01e1c827_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:to="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaterialSalesCaptisolMember_8fe59f48-aa99-4387-a95f-28cf41fd7433" xlink:href="lgnd-20181231.xsd#lgnd_MaterialSalesCaptisolMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:to="loc_lgnd_MaterialSalesCaptisolMember_8fe59f48-aa99-4387-a95f-28cf41fd7433" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesandProductOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:to="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMember_4b710680-2c65-4cfc-949d-bacde2acbe60" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_LicenseFeesMember_4b710680-2c65-4cfc-949d-bacde2acbe60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestoneMember_4cd6320e-fac5-4ff1-9dfb-0b6df2a036c2" xlink:href="lgnd-20181231.xsd#lgnd_MilestoneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_MilestoneMember_4cd6320e-fac5-4ff1-9dfb-0b6df2a036c2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_abfa8191-cda0-4ee7-a3c0-b75128e2eea7" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesAndOtherProductOtherMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_abfa8191-cda0-4ee7-a3c0-b75128e2eea7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7dad168d-e29c-4388-947b-9247104558e8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7dad168d-e29c-4388-947b-9247104558e8" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="extended" id="if0f9efee8ce4423c9828ff7768dcad96_15f5c23b-cfa5-42fb-92ed-f7256f848fb1">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_5d8c9a81-9a85-42dc-98f6-c1771ab2b5d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:to="loc_us-gaap_LicensingAgreementsMember_5d8c9a81-9a85-42dc-98f6-c1771ab2b5d1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:to="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_12a941bf-0313-4bbc-b8ee-43b4e70f04bd_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_12a941bf-0313-4bbc-b8ee-43b4e70f04bd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoandCorMatrixMember_6b422018-31f1-46cc-a980-f809720f4d9c" xlink:href="lgnd-20181231.xsd#lgnd_AziyoandCorMatrixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_AziyoandCorMatrixMember_6b422018-31f1-46cc-a980-f809720f4d9c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_05683a62-506e-41f8-9eac-cfe8ca11e545" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_05683a62-506e-41f8-9eac-cfe8ca11e545" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_SelexisMember_8182dacd-65c4-4df3-92da-63faffdb2ea5" xlink:href="lgnd-20181231.xsd#lgnd_SelexisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_SelexisMember_8182dacd-65c4-4df3-92da-63faffdb2ea5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5cd1ae31-8c1b-4e6a-bd54-509b0a811b40" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5cd1ae31-8c1b-4e6a-bd54-509b0a811b40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eb13cdc9-662c-4ae4-8a9d-1b2c7a6cb0ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eb13cdc9-662c-4ae4-8a9d-1b2c7a6cb0ce" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0d5c3457-0218-4cd6-a9df-c660589a4752" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0d5c3457-0218-4cd6-a9df-c660589a4752" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="extended" id="i00dafcb44504492bab299b61f8ed26a6_9cd5f288-a40a-4519-a679-66519322166e">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_fb978042-0608-40a3-88ce-aa421e4d7226_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_fb978042-0608-40a3-88ce-aa421e4d7226_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_3144b40c-d8a9-43fc-8feb-8d8b44cc9c97" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_3144b40c-d8a9-43fc-8feb-8d8b44cc9c97" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_966268d2-f6f0-42af-a7cb-9a655a308fc0_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_966268d2-f6f0-42af-a7cb-9a655a308fc0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_c12e823d-affe-4d4f-b446-25be6cd3f84f" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_c12e823d-affe-4d4f-b446-25be6cd3f84f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_ee6001ed-fc8b-4e58-93cd-0e6b10cfb012" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_ee6001ed-fc8b-4e58-93cd-0e6b10cfb012" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_6b759b47-a372-4dcb-ab23-4f06d904c99c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_6b759b47-a372-4dcb-ab23-4f06d904c99c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e92b6f52-117a-402e-b711-53e0e4e8ab9f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e92b6f52-117a-402e-b711-53e0e4e8ab9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_b85e5dc7-f652-477b-89a1-da683cb8d0ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_b85e5dc7-f652-477b-89a1-da683cb8d0ee" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_aea87594-d054-43c5-8d56-7e9fe9d39009" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_aea87594-d054-43c5-8d56-7e9fe9d39009" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputCouponRateMember_cc814f61-6b47-4344-bcae-11f77117d171" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputCouponRateMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_lgnd_MeasurementInputCouponRateMember_cc814f61-6b47-4344-bcae-11f77117d171" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputRemainingTermMember_9a03c75a-0e23-496c-abbc-80e6de3f5e61" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputRemainingTermMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_lgnd_MeasurementInputRemainingTermMember_9a03c75a-0e23-496c-abbc-80e6de3f5e61" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_07d4d718-41ca-4f8d-8b8e-d590eb30ed37_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:to="loc_srt_RangeMember_07d4d718-41ca-4f8d-8b8e-d590eb30ed37_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:to="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_0beb4db4-d8da-4f0c-a200-2691e9ac282a" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:to="loc_srt_MinimumMember_0beb4db4-d8da-4f0c-a200-2691e9ac282a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_dcbbfc81-1e76-4ed7-bf70-c697ee0f13a6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:to="loc_srt_MaximumMember_dcbbfc81-1e76-4ed7-bf70-c697ee0f13a6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_f283d4e7-2849-49fc-820c-dcc816d403c9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_us-gaap_SharePrice_f283d4e7-2849-49fc-820c-dcc816d403c9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceofConvertibleBondHedge_0540646c-1957-46d3-ba18-389e2d4fcad5" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceofConvertibleBondHedge"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_lgnd_ExercisePriceofConvertibleBondHedge_0540646c-1957-46d3-ba18-389e2d4fcad5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_invest_InvestmentWarrantsExercisePrice_3f91abb1-ae99-4aca-934e-44fc98ebb7d2" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentWarrantsExercisePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_invest_InvestmentWarrantsExercisePrice_3f91abb1-ae99-4aca-934e-44fc98ebb7d2" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityMeasurementInput_bc7ce23f-1829-4f95-841b-98f5f41c60ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilityMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_us-gaap_DerivativeLiabilityMeasurementInput_bc7ce23f-1829-4f95-841b-98f5f41c60ec" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="extended" id="i5160a337113845c0805b31ff1f1b60ff_3215e734-fd9c-4c12-8552-9d3e70afc9c6"/>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinViking" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinViking"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/InvestmentinViking" xlink:type="extended" id="i62dec03d896e43c2ae4526eaac4654e7_3a78e07c-1962-4431-b3f1-9e450e6f6167"/>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinVikingNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="extended" id="idfe912cb81dc4a23845da6f491616e2f_9c901077-f03e-4024-8dd3-08fcdc9ef7b8">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_deb3a714-8ac2-4b2e-accf-ce9ff9b76825_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:to="loc_srt_OwnershipDomain_deb3a714-8ac2-4b2e-accf-ce9ff9b76825_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:to="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_73bee3ba-207e-482d-9b30-ca9cdf60c331" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_73bee3ba-207e-482d-9b30-ca9cdf60c331" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0f2c72f2-cf04-4079-b1ec-f91d2041630d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_0f2c72f2-cf04-4079-b1ec-f91d2041630d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_dc4c57cf-a19c-41c8-ada7-21c3bb46af6a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:to="loc_us-gaap_WarrantMember_dc4c57cf-a19c-41c8-ada7-21c3bb46af6a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_5318c741-75e6-409b-bad2-49030e70b509_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:to="loc_us-gaap_RelatedPartyDomain_5318c741-75e6-409b-bad2-49030e70b509_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:to="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvesteeMember_4f859713-9f53-4103-91f8-fc585bb38578" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvesteeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:to="loc_us-gaap_EquityMethodInvesteeMember_4f859713-9f53-4103-91f8-fc585bb38578" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_ff3d984f-bcac-423b-9b3e-fe51391e98b7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_ff3d984f-bcac-423b-9b3e-fe51391e98b7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember_a114e9a7-6a95-4187-aa8e-6e82e6bb3761" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:to="loc_us-gaap_DebtMember_a114e9a7-6a95-4187-aa8e-6e82e6bb3761" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_4e2f5ff2-0052-4487-8ddf-300837849571_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_4e2f5ff2-0052-4487-8ddf-300837849571_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_76ec4009-a0e9-4d67-ba5e-9947ff2cc3cb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_76ec4009-a0e9-4d67-ba5e-9947ff2cc3cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_ebff165a-cb65-486c-9eab-9b4b8325efc6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_ebff165a-cb65-486c-9eab-9b4b8325efc6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_0e079d7d-9719-4c16-9472-4b202b66f4d6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_0e079d7d-9719-4c16-9472-4b202b66f4d6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment_080b07ed-b3e6-4f17-9f74-3fac6c9f84b5" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinEquityMethodInvestment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment_080b07ed-b3e6-4f17-9f74-3fac6c9f84b5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_647f81a1-e67b-474f-bacd-23214bd36300" xlink:href="lgnd-20181231.xsd#lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_647f81a1-e67b-474f-bacd-23214bd36300" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_5e315a2b-7343-4b23-8a15-e3100f0426aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_5e315a2b-7343-4b23-8a15-e3100f0426aa" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent_fe6c9816-900d-47e4-a5c1-8a41a2ab11a2" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableAmountDueUponTriggeringEvent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent_fe6c9816-900d-47e4-a5c1-8a41a2ab11a2" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_4ebff050-c773-49a9-aa98-f3ed141e1978" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_4ebff050-c773-49a9-aa98-f3ed141e1978" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_292d838f-3768-4a57-9ca0-4e5396e71371" xlink:href="lgnd-20181231.xsd#lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_292d838f-3768-4a57-9ca0-4e5396e71371" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent_b623402b-6e85-4226-a350-74517b73c4d6" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableCashDueUponTriggeringEvent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent_b623402b-6e85-4226-a350-74517b73c4d6" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_72913aae-f0ba-4258-b047-a00963ff2b2e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_72913aae-f0ba-4258-b047-a00963ff2b2e" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_46c086c8-f7ff-44e1-88fc-9a22c6ffad79" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_46c086c8-f7ff-44e1-88fc-9a22c6ffad79" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_c95ac271-0d16-467d-b561-a2b1f40bd0eb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_c95ac271-0d16-467d-b561-a2b1f40bd0eb" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_7539766a-c3dd-4811-b617-51f4e64a802e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_7539766a-c3dd-4811-b617-51f4e64a802e" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfInvestments_daea6522-68ce-4250-87f4-b3bb3e6cc5d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfInvestments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ImpairmentOfInvestments_daea6522-68ce-4250-87f4-b3bb3e6cc5d1" xlink:type="arc" order="14"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinations"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BusinessCombinations" xlink:type="extended" id="i4db0edd065794c0cb8272ebf9ae567e5_26659c8b-9793-4b3e-9bf4-f89e35dfcb27"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="extended" id="i450e2d0d0689453a988d819380b4e3f1_b1ca6f69-a59b-460d-b117-5bb9a5c8af68">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_fb45b788-a2cb-46ec-b277-d171163a6123_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_fb45b788-a2cb-46ec-b277-d171163a6123_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_6b866e92-1169-4a5c-8ddc-56389d2446f3" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_VernalisMember_6b866e92-1169-4a5c-8ddc-56389d2446f3" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_9775e1c9-42f4-49d9-ac6d-7e1f6c05ebcf" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_CrystalMember_9775e1c9-42f4-49d9-ac6d-7e1f6c05ebcf" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_af7b5685-254f-4970-bf93-601fdf432dcd" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_OMTInc.Member_af7b5685-254f-4970-bf93-601fdf432dcd" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_9e42bdb2-2101-4dc3-ad7b-dfe4b9b8a7c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_9e42bdb2-2101-4dc3-ad7b-dfe4b9b8a7c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_d4d2c628-605f-4b01-933c-f3fc80c60259" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:to="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_d4d2c628-605f-4b01-933c-f3fc80c60259" xlink:type="arc" order="2"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="extended" id="i0d09bff69fc24561b6f13f657f42c002_84fcf5ea-c59b-4c0a-8407-1e54fcd2f491">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216_default" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:to="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:to="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_47584c46-3fb3-4253-bbcd-e08bd4849083" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:to="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_47584c46-3fb3-4253-bbcd-e08bd4849083" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_706a1dc5-19cf-4d76-ae2b-98bbb5ea1314" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:to="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_706a1dc5-19cf-4d76-ae2b-98bbb5ea1314" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_961f0264-51cd-44cb-b5a4-38df5ca0823a_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_961f0264-51cd-44cb-b5a4-38df5ca0823a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_e1421a56-3405-4640-a0b7-5a6dd74c4525" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_e1421a56-3405-4640-a0b7-5a6dd74c4525" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_9224a268-ac83-4ba7-8420-569790a6e553_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_9224a268-ac83-4ba7-8420-569790a6e553_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_5a7c5270-e85a-4c17-a448-32201e59964b" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_VernalisMember_5a7c5270-e85a-4c17-a448-32201e59964b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_7ba609f8-5d74-4b71-95fb-10f536a7cb24" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_CrystalMember_7ba609f8-5d74-4b71-95fb-10f536a7cb24" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_67b8240e-8de6-4bb8-95c0-876891810e7f" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_OMTInc.Member_67b8240e-8de6-4bb8-95c0-876891810e7f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_fec43594-c726-499f-af4f-2ebf09e6af16" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_fec43594-c726-499f-af4f-2ebf09e6af16" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_e5f67246-9959-4043-9105-58294ae97a47" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_e5f67246-9959-4043-9105-58294ae97a47" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WorkingCapitalAdjustment_61598e4f-41f5-4eaf-a64a-607b3964bfa3" xlink:href="lgnd-20181231.xsd#lgnd_WorkingCapitalAdjustment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_WorkingCapitalAdjustment_61598e4f-41f5-4eaf-a64a-607b3964bfa3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_d9940cba-85c6-4b81-8c56-d47adbdb3e70" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_d9940cba-85c6-4b81-8c56-d47adbdb3e70" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_7d94d4a5-6cf3-48a0-92c5-37c6c139679b" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_7d94d4a5-6cf3-48a0-92c5-37c6c139679b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_38760605-a23d-4747-b3a2-9e0a7e796f8f" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_38760605-a23d-4747-b3a2-9e0a7e796f8f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberofCollaborationAgreements_16083860-4891-45c3-9e3e-28bd355b96ab" xlink:href="lgnd-20181231.xsd#lgnd_NumberofCollaborationAgreements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_NumberofCollaborationAgreements_16083860-4891-45c3-9e3e-28bd355b96ab" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPayable_bbaf1926-3860-4a54-9d7d-62c79990f22f" xlink:href="lgnd-20181231.xsd#lgnd_CashPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_CashPayable_bbaf1926-3860-4a54-9d7d-62c79990f22f" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_0337453d-8a90-44a0-9acb-745213460c47" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_0337453d-8a90-44a0-9acb-745213460c47" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_4194abb1-d89e-4f43-9d7c-6e256920d490" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_4194abb1-d89e-4f43-9d7c-6e256920d490" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8bb88d5a-6c9b-4d50-b1fd-89d6005b9a81" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8bb88d5a-6c9b-4d50-b1fd-89d6005b9a81" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5288f2a0-bfb6-49d4-89d2-c6e599f90270" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_Goodwill_5288f2a0-bfb6-49d4-89d2-c6e599f90270" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_7eef172a-2d73-41b2-901f-d945cbb90c29" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_7eef172a-2d73-41b2-901f-d945cbb90c29" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended" id="i6fdcc26d1a1f42699c9422ed70d81cde_277bec4a-85e5-47b0-8c19-4fc9451ff806">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d12e7dfd-1611-464e-89dc-a678268c69ff_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d12e7dfd-1611-464e-89dc-a678268c69ff_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_5b8a6e45-42c2-4a06-8400-a5e9a1306142" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_VernalisMember_5b8a6e45-42c2-4a06-8400-a5e9a1306142" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_06e31e20-b721-4809-aa7e-1f4e7df7d31c" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_CrystalMember_06e31e20-b721-4809-aa7e-1f4e7df7d31c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_2e5f4302-5a49-4803-9a00-0ffb4ed13485" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_OMTInc.Member_2e5f4302-5a49-4803-9a00-0ffb4ed13485" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dd8938d4-b32b-4c79-8275-3ea47c9f774c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dd8938d4-b32b-4c79-8275-3ea47c9f774c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_3edc7602-1874-4dad-a4aa-1b6692dcc112" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_3edc7602-1874-4dad-a4aa-1b6692dcc112" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_b2169e84-0902-4b47-bc58-96165a7229d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_b2169e84-0902-4b47-bc58-96165a7229d9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_1afe9d91-bc6d-4001-b904-eed8aa4b72c1" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_1afe9d91-bc6d-4001-b904-eed8aa4b72c1" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_9eb252ba-7641-41bd-9d7b-0f3c4dc4f92b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_9eb252ba-7641-41bd-9d7b-0f3c4dc4f92b" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_1ad1991e-588d-47b9-86d8-b28b56f5df60" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_1ad1991e-588d-47b9-86d8-b28b56f5df60" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_18ce54bb-5764-4018-a817-7ec8bb91aeec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_18ce54bb-5764-4018-a817-7ec8bb91aeec" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_74acd982-93bc-48e0-a753-fb69b33ac735" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_74acd982-93bc-48e0-a753-fb69b33ac735" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_57a92f2b-7fdf-48c1-9851-cd36eec02ac3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_57a92f2b-7fdf-48c1-9851-cd36eec02ac3" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_c038ea62-1d4a-45df-8908-05b5914df295" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_RestructuringReserve_c038ea62-1d4a-45df-8908-05b5914df295" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_d0ca4aea-17db-485b-9514-a513bac0b33f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_d0ca4aea-17db-485b-9514-a513bac0b33f" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_6c070f3c-2f2c-4856-b9dd-edbd788e1984" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_6c070f3c-2f2c-4856-b9dd-edbd788e1984" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_c9e92b5d-36ba-4ad5-8717-d6d8bb252b90" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_c9e92b5d-36ba-4ad5-8717-d6d8bb252b90" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2ac370bb-dbc9-4731-b215-4549d1e2c206" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2ac370bb-dbc9-4731-b215-4549d1e2c206" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_efae33e3-4c4c-482c-b4c1-dc5ad8c5807b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_Goodwill_efae33e3-4c4c-482c-b4c1-dc5ad8c5807b" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a31ee220-acbc-408f-baeb-02125b7fc6d0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a31ee220-acbc-408f-baeb-02125b7fc6d0" xlink:type="arc" order="16"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsConsiderationTransferredDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="extended" id="i6574276b9f774ff083dddbe698887c04_ecfcf61a-f13a-49cb-bf49-57a1ca8aa057">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_e3993c33-a939-43bb-b9f2-e156c07d9a58" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:to="loc_lgnd_CrystalMember_e3993c33-a939-43bb-b9f2-e156c07d9a58" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_6d9feaad-1522-4a8f-92c8-4956b157a6c5" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:to="loc_lgnd_OMTInc.Member_6d9feaad-1522-4a8f-92c8-4956b157a6c5" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPaidtoAcquireBusiness_e8c75801-6a4d-4179-9bbe-9a85ba9186b7" xlink:href="lgnd-20181231.xsd#lgnd_CashPaidtoAcquireBusiness"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_CashPaidtoAcquireBusiness_e8c75801-6a4d-4179-9bbe-9a85ba9186b7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPayable_52d845f7-1f3a-41b5-ae59-37c2bf3f9d98" xlink:href="lgnd-20181231.xsd#lgnd_CashPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_CashPayable_52d845f7-1f3a-41b5-ae59-37c2bf3f9d98" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_9ef59607-5cac-43fe-b055-cbc0cfaca514" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_9ef59607-5cac-43fe-b055-cbc0cfaca514" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_2d689f2a-0312-40be-b0c8-8652b92154e0" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_2d689f2a-0312-40be-b0c8-8652b92154e0" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_2832eef4-25a3-464f-b462-feb4b01bd413" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_2832eef4-25a3-464f-b462-feb4b01bd413" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_973d96f9-1784-4ef3-ae9c-c3c84e1d0f4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_973d96f9-1784-4ef3-ae9c-c3c84e1d0f4e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_d163b413-37c6-4c90-a036-f487a80899f6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_SharePrice_d163b413-37c6-4c90-a036-f487a80899f6" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_9df999df-52cb-43ec-ab93-d947ffce0836" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_9df999df-52cb-43ec-ab93-d947ffce0836" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_071b0965-8de7-47ac-b086-0f9e5928364c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_071b0965-8de7-47ac-b086-0f9e5928364c" xlink:type="arc" order="9"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurement"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/FairValueMeasurement" xlink:type="extended" id="i4dc7872c95e74dd684773a1709fdcf35_dedb0dcb-2ef8-464a-9ffc-571cbb6d6b40"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="extended" id="ib03af3cf39cb4904a90cbe99fb09113a_6eb6487b-ee43-4d0d-8bba-3911c9f81445"/>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended" id="i05b3bb59e1224263a9e31ff485d97b5c_eb1d9416-447f-4ae0-a828-08fddb8e7758">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_1e714f73-7ab4-4c17-933f-32272c7aea0d_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:to="loc_srt_RangeMember_1e714f73-7ab4-4c17-933f-32272c7aea0d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:to="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_de3aeaa9-d9a0-4771-9046-74254863dd95" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:to="loc_srt_MaximumMember_de3aeaa9-d9a0-4771-9046-74254863dd95" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember_01613492-1b99-4098-830b-19623c03a4ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransferredOverTimeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:to="loc_us-gaap_TransferredOverTimeMember_01613492-1b99-4098-830b-19623c03a4ee" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_60d1509e-a636-466c-97d6-5ee210e8b8f0_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:to="loc_srt_ProductsAndServicesDomain_60d1509e-a636-466c-97d6-5ee210e8b8f0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:to="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_25f8b3d3-94f9-466f-a0f2-eea9ea3b09d7" xlink:href="lgnd-20181231.xsd#lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_25f8b3d3-94f9-466f-a0f2-eea9ea3b09d7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_Phase3ClinicalTrialMember_773b45df-9f5f-44ac-b4c4-840558db2b70" xlink:href="lgnd-20181231.xsd#lgnd_Phase3ClinicalTrialMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_Phase3ClinicalTrialMember_773b45df-9f5f-44ac-b4c4-840558db2b70" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestonePaymentsAndRoyaltiesMember_18c18f68-8c99-4bd0-88b0-2908a122531a" xlink:href="lgnd-20181231.xsd#lgnd_MilestonePaymentsAndRoyaltiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_MilestonePaymentsAndRoyaltiesMember_18c18f68-8c99-4bd0-88b0-2908a122531a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_610072a4-c13b-4321-9645-6437acebeb9c_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_610072a4-c13b-4321-9645-6437acebeb9c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_202024d5-9b88-485a-8584-774d8749b56b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_202024d5-9b88-485a-8584-774d8749b56b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_165437fb-ae92-4144-af2b-fc1ae9e64dec_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_165437fb-ae92-4144-af2b-fc1ae9e64dec_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_d3e9adf3-bf88-4114-9534-b01881fdad73" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_d3e9adf3-bf88-4114-9534-b01881fdad73" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_423dc49b-414a-4308-a224-19834943c92f_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_423dc49b-414a-4308-a224-19834943c92f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_a1d9f8ad-6ab2-46db-8126-82bea9a99804" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_a1d9f8ad-6ab2-46db-8126-82bea9a99804" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_ef40369a-9191-4bd1-837a-dfaf6876dcb4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_ef40369a-9191-4bd1-837a-dfaf6876dcb4" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_af4ef7f9-6331-4da3-95fc-8a2b27354922" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_af4ef7f9-6331-4da3-95fc-8a2b27354922" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_c6502433-34e7-4c7d-899b-e2dc6d9475d8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_c6502433-34e7-4c7d-899b-e2dc6d9475d8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_7cf256e0-4b59-483d-b97a-53f7abae2599" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_7cf256e0-4b59-483d-b97a-53f7abae2599" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableMember_abd834ad-0d7c-496d-a5e9-4c91e0b38d50" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_NotesReceivableMember_abd834ad-0d7c-496d-a5e9-4c91e0b38d50" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_c696a93b-b02c-4ada-b28a-8f0b56f4dc79" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_WarrantMember_c696a93b-b02c-4ada-b28a-8f0b56f4dc79" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_fbc4b964-2979-4011-974e-c937a9155098_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_fbc4b964-2979-4011-974e-c937a9155098_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_16be8efd-08ba-44be-858a-07e40e4b4aa5" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_16be8efd-08ba-44be-858a-07e40e4b4aa5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_5f5ac6b4-0b8c-4d3b-9ac6-dbd605296497" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCydexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_5f5ac6b4-0b8c-4d3b-9ac6-dbd605296497" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_f3ea3234-521e-4931-b3da-7616d25609ec" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_f3ea3234-521e-4931-b3da-7616d25609ec" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_31e10898-0c2e-4850-959a-fba876b2ca70" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_31e10898-0c2e-4850-959a-fba876b2ca70" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_f0bf92ab-071c-4145-9271-9d082c5ed5bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_f0bf92ab-071c-4145-9271-9d082c5ed5bb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_f6795747-23ce-45ab-b8d8-87ab4866c4ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_f6795747-23ce-45ab-b8d8-87ab4866c4ed" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AlternativeInvestmentMeasurementInput_d3e1942e-4166-465f-b4ec-ebe5070af3af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AlternativeInvestmentMeasurementInput"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_AlternativeInvestmentMeasurementInput_d3e1942e-4166-465f-b4ec-ebe5070af3af" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_60ec97b9-3806-4126-9d2e-6509ca0a058b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_60ec97b9-3806-4126-9d2e-6509ca0a058b" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_54e44dda-c192-426c-b4f1-959be386b0e3" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_54e44dda-c192-426c-b4f1-959be386b0e3" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetGross_4c4f8582-ee23-4949-8d1e-d82cfe5d8706" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_ContractWithCustomerAssetGross_4c4f8582-ee23-4949-8d1e-d82cfe5d8706" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="extended" id="icc103a792ef74fffb846afba59bdfa12_05c54468-373d-48c8-906d-3e83b012e0e4">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d1bf4f29-30e8-4196-9898-29e7964cd11d_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_d1bf4f29-30e8-4196-9898-29e7964cd11d_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_2867ca9d-f8b3-4ac3-9132-f01b153c0660" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CrystalMember_2867ca9d-f8b3-4ac3-9132-f01b153c0660" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexMember_a76bcc50-2cc0-4fdc-928f-d0dede81e90e" xlink:href="lgnd-20181231.xsd#lgnd_CydexMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CydexMember_a76bcc50-2cc0-4fdc-928f-d0dede81e90e" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexandCrystalMember_e18fbd73-765f-4fe4-9cca-8e6c109ed40f" xlink:href="lgnd-20181231.xsd#lgnd_CydexandCrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CydexandCrystalMember_e18fbd73-765f-4fe4-9cca-8e6c109ed40f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_ef64758e-72c1-442c-8605-183748734412_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_ef64758e-72c1-442c-8605-183748734412_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_6d5b0280-d22a-48f6-8da4-68a7f7980619" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_6d5b0280-d22a-48f6-8da4-68a7f7980619" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_590d0da0-5180-4803-97f2-28798cee277f_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_590d0da0-5180-4803-97f2-28798cee277f_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_0b1119f5-a404-4d21-841b-efba22c73aeb" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_0b1119f5-a404-4d21-841b-efba22c73aeb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_15f7c2ca-85da-43a6-8105-c78e4ce93959_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_15f7c2ca-85da-43a6-8105-c78e4ce93959_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_a4ebc76e-1557-424a-8a73-2ec5571077dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:to="loc_us-gaap_SeniorNotesMember_a4ebc76e-1557-424a-8a73-2ec5571077dc" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_2f187e1a-785d-48c3-81d0-9dadbd074ed7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_2f187e1a-785d-48c3-81d0-9dadbd074ed7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_c1140c2e-d3bb-4aea-a18b-6dfe7cfdc213" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_c1140c2e-d3bb-4aea-a18b-6dfe7cfdc213" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_07b1ea39-2069-4f03-bc4c-64d14a37fb19" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_07b1ea39-2069-4f03-bc4c-64d14a37fb19" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_13fde998-f8a8-4463-b3d9-39b57568f3cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_ec204e5a-9ce4-45f6-86c6-424a1f74a917" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_ec204e5a-9ce4-45f6-86c6-424a1f74a917" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHolders_d32a8f20-9ec8-4a08-8dc5-380df5bc75e0" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_lgnd_PaymentsToContingentValueRightHolders_d32a8f20-9ec8-4a08-8dc5-380df5bc75e0" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_da0690f0-fa85-4f8a-960d-bf6f957e89c3" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_da0690f0-fa85-4f8a-960d-bf6f957e89c3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_eff4d3fc-d79c-4ae6-9ec3-7cfa4800921f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligations"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/LeaseObligations" xlink:type="extended" id="id2795359de1d43d08f3fb7c324aefabd_3c325d70-f873-4ed9-a8cf-b31f6bd2bcd0"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="extended" id="i45ac58d5291a46279e3a62940a3002c9_954a138d-bc25-4ffe-afc0-f3ff02b99210"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="extended" id="i6efcd8009d54487cb0696a9d9c1a2ee7_5b5339f7-d4b2-471e-b768-c7f4946eef80"/>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="extended" id="i15ac12d368c942d2a7c75ecad5d17d33_9862db09-6de4-4a40-98f9-43c1a0b72b84">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_afda4c3d-1a2f-4998-b2a5-63baaa81568b_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_afda4c3d-1a2f-4998-b2a5-63baaa81568b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateHeadquartersSanDiegoCAMember_8b76647e-8c0f-4a65-999a-374150247a88" xlink:href="lgnd-20181231.xsd#lgnd_CorporateHeadquartersSanDiegoCAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_CorporateHeadquartersSanDiegoCAMember_8b76647e-8c0f-4a65-999a-374150247a88" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember_ff023567-9c4e-40fb-b531-af3a1692d562" xlink:href="lgnd-20181231.xsd#lgnd_OfficeandResearchFacilityLaJollaCAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember_ff023567-9c4e-40fb-b531-af3a1692d562" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_678e5555-ae23-4942-aef0-d2aba2384dda" xlink:href="lgnd-20181231.xsd#lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_678e5555-ae23-4942-aef0-d2aba2384dda" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeEmeryvilleCAMember_b3f70ece-2e29-4cf5-a6c5-3412a9c8e087" xlink:href="lgnd-20181231.xsd#lgnd_OfficeEmeryvilleCAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeEmeryvilleCAMember_b3f70ece-2e29-4cf5-a6c5-3412a9c8e087" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityEmeryvilleCAMember_13a7122b-8ae3-471e-8994-d2c21a80227a" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityEmeryvilleCAMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_ResearchFacilityEmeryvilleCAMember_13a7122b-8ae3-471e-8994-d2c21a80227a" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeWinnershUnitedKingdomMember_253b0168-c0a6-4e4b-ae00-cf66c074df8e" xlink:href="lgnd-20181231.xsd#lgnd_OfficeWinnershUnitedKingdomMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeWinnershUnitedKingdomMember_253b0168-c0a6-4e4b-ae00-cf66c074df8e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_1b583ac1-3db5-414c-a457-2b309aacc4f2" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityCambridgeUnitedKingdomMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_1b583ac1-3db5-414c-a457-2b309aacc4f2" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:to="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:to="loc_srt_SegmentGeographicalDomain_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:to="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_CA_92523ace-11e4-4c9b-95f5-7875c4770544" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_CA"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_stpr_CA_92523ace-11e4-4c9b-95f5-7875c4770544" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_KS_9e89f9cc-7231-4c85-b4ba-7f28bf6fa5c9" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_KS"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_stpr_KS_9e89f9cc-7231-4c85-b4ba-7f28bf6fa5c9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_26f4dbd4-7471-4389-bfee-9f167fdaa9e7" xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_GB"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_country_GB_26f4dbd4-7471-4389-bfee-9f167fdaa9e7" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOperatingAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:to="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_aa0ee12d-7d2e-4718-9006-7608d16a8006" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_aa0ee12d-7d2e-4718-9006-7608d16a8006" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_88402da9-47e3-4841-a143-c925a48ae054" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_88402da9-47e3-4841-a143-c925a48ae054" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_485df591-0144-4ee0-befa-fb6dc9c3ee4f" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_485df591-0144-4ee0-befa-fb6dc9c3ee4f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_7605a001-8c88-41eb-97fa-abef864dd78a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_7605a001-8c88-41eb-97fa-abef864dd78a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_e3e9d7f6-8cc8-4e28-853a-b0f299e481fd" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_e3e9d7f6-8cc8-4e28-853a-b0f299e481fd" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_fec03709-4f85-4bec-a2e5-11a43ad54c25" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_fec03709-4f85-4bec-a2e5-11a43ad54c25" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_fb167081-e82e-4d82-ab6d-f257258b679f" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_fb167081-e82e-4d82-ab6d-f257258b679f" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_ba883b28-d6dc-4361-9b29-b99fd3bd6a15" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_ba883b28-d6dc-4361-9b29-b99fd3bd6a15" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_784680da-7217-4a5d-a861-8ad14f1d76cd" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_784680da-7217-4a5d-a861-8ad14f1d76cd" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_4b02080b-825f-48b8-ba0e-95299c06d638" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_4b02080b-825f-48b8-ba0e-95299c06d638" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_e1d8c186-bed3-47f0-8de1-fc3e5ef0d6ad" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_e1d8c186-bed3-47f0-8de1-fc3e5ef0d6ad" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_cd81c1df-9fe5-4109-9d56-39fa538ef68a" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_cd81c1df-9fe5-4109-9d56-39fa538ef68a" xlink:type="arc" order="12"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotes"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="extended" id="ie300bc1be3c24188984e8f00f17abd2c_714bb593-6b05-45d3-99d0-849d5ac520a2"/>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="extended" id="i090332e076eb49e6b45e10a4400bd2c3_eb67eed7-34b7-4fd2-9716-c850b4a39d01"/>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="extended" id="i5659085028284e099898a82f3b16582f_2cf66295-0ebc-4544-905a-f513ca9861e0">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_08a6468c-23b3-4734-85a3-805a66c82e60_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_08a6468c-23b3-4734-85a3-805a66c82e60_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_914ae39c-48c2-4102-aa9d-12498f8e488a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_914ae39c-48c2-4102-aa9d-12498f8e488a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4774523c-79c8-443d-8ff4-65129ac11e67_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4774523c-79c8-443d-8ff4-65129ac11e67_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_09e3d820-b99c-434e-a723-85a862422047" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_09e3d820-b99c-434e-a723-85a862422047" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_a335e6fd-6145-4dd9-9935-6900f35c522f" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_a335e6fd-6145-4dd9-9935-6900f35c522f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_b2cfbada-ca06-47fd-9123-7b5a8b48d53e_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_b2cfbada-ca06-47fd-9123-7b5a8b48d53e_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_3366ca6a-8fe3-420a-9000-0c77160ae63e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_3366ca6a-8fe3-420a-9000-0c77160ae63e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_dbc1cd6b-3775-4ef9-8866-d8113591be0f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_dbc1cd6b-3775-4ef9-8866-d8113591be0f" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_e6589bdf-546b-4a3b-8e28-241cbad75aba" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_e6589bdf-546b-4a3b-8e28-241cbad75aba" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_89240001-84a6-48f0-ae8e-306427859e3d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_89240001-84a6-48f0-ae8e-306427859e3d" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_5d35072c-57ce-4a0d-b256-425eff734a26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_5d35072c-57ce-4a0d-b256-425eff734a26" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_7b624207-9e2a-405f-9cbd-626b21f18382" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_7b624207-9e2a-405f-9cbd-626b21f18382" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_8551cac7-ad33-4c39-a631-60e402661b4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_8551cac7-ad33-4c39-a631-60e402661b4e" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c77a45d0-8d7d-426c-bd5a-d03abddfa8d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c77a45d0-8d7d-426c-bd5a-d03abddfa8d1" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_4e334203-5919-4561-b15c-efc7329873ad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_4e334203-5919-4561-b15c-efc7329873ad" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_afbde1ab-e3fe-4ae0-a4db-2edacb56f47a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_afbde1ab-e3fe-4ae0-a4db-2edacb56f47a" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_26eafd80-a84e-497f-8962-3ca83b0861f9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_26eafd80-a84e-497f-8962-3ca83b0861f9" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_c1aeb084-a4a3-460f-a4be-68b38a9580f6" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_c1aeb084-a4a3-460f-a4be-68b38a9580f6" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_df1da3ce-b958-4269-aa15-af3ec32f81d6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_df1da3ce-b958-4269-aa15-af3ec32f81d6" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_4edda9eb-229e-416c-80a5-459efd113a0f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_4edda9eb-229e-416c-80a5-459efd113a0f" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_9aac0aae-f682-450c-9704-897207cc6071" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_9aac0aae-f682-450c-9704-897207cc6071" xlink:type="arc" order="13"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_51552ded-b922-4ebc-a8bc-1d5b75d0a77c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_51552ded-b922-4ebc-a8bc-1d5b75d0a77c" xlink:type="arc" order="14"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_dfee3921-3eea-4d9a-9c8c-a4b326e331b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_dfee3921-3eea-4d9a-9c8c-a4b326e331b8" xlink:type="arc" order="15"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a7254fe-dae1-4f90-b73d-6a7531acd6ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a7254fe-dae1-4f90-b73d-6a7531acd6ce" xlink:type="arc" order="16"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_15b3275a-97b2-4abc-a546-f7c3207f347a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_15b3275a-97b2-4abc-a546-f7c3207f347a" xlink:type="arc" order="17"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceofConvertibleBondHedge_2a1b7bc9-c0b4-4016-aff6-77de8c96b56f" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceofConvertibleBondHedge"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_ExercisePriceofConvertibleBondHedge_2a1b7bc9-c0b4-4016-aff6-77de8c96b56f" xlink:type="arc" order="18"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsforConvertibleBondHedges_127c3cbb-b8be-4c0e-890c-392523db8d8f" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsforConvertibleBondHedges"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_PaymentsforConvertibleBondHedges_127c3cbb-b8be-4c0e-890c-392523db8d8f" xlink:type="arc" order="19"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_27d4ae7b-9071-4d51-954e-4b9df4f50aee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_27d4ae7b-9071-4d51-954e-4b9df4f50aee" xlink:type="arc" order="20"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1d26d7ee-6d4d-4512-8c4e-a89552f91a4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1d26d7ee-6d4d-4512-8c4e-a89552f91a4c" xlink:type="arc" order="21"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_1e48be64-c1eb-4d9a-8341-43b82cb710a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_1e48be64-c1eb-4d9a-8341-43b82cb710a3" xlink:type="arc" order="22"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7254ee3d-eea2-4bdc-8cde-ddc551535d95" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7254ee3d-eea2-4bdc-8cde-ddc551535d95" xlink:type="arc" order="23"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_8214874f-b6d6-46e5-a18e-eb5d779a6123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_8214874f-b6d6-46e5-a18e-eb5d779a6123" xlink:type="arc" order="24"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_0497e767-7f59-43d7-a44c-647df3c5d3a8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_0497e767-7f59-43d7-a44c-647df3c5d3a8" xlink:type="arc" order="25"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_78e1d26e-40b8-42bb-b867-936bfb77a132" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_78e1d26e-40b8-42bb-b867-936bfb77a132" xlink:type="arc" order="26"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_751210e0-acaf-4f75-a73e-0df728e618fd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_751210e0-acaf-4f75-a73e-0df728e618fd" xlink:type="arc" order="27"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_97fd92f4-d30b-4531-a9cf-ae6b4cebe501" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_97fd92f4-d30b-4531-a9cf-ae6b4cebe501" xlink:type="arc" order="28"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_00ce2155-d17e-4dcd-a781-7c9dbd5b9e2f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_00ce2155-d17e-4dcd-a781-7c9dbd5b9e2f" xlink:type="arc" order="29"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsSettled_c780f3f8-ce34-4810-9ae2-e863844f168f" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsSettled"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_WarrantsSettled_c780f3f8-ce34-4810-9ae2-e863844f168f" xlink:type="arc" order="30"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_cce8499a-15e7-48a9-8224-f4b2c66f63a1" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_cce8499a-15e7-48a9-8224-f4b2c66f63a1" xlink:type="arc" order="31"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1e045ef0-315b-4de9-819b-4e64180072a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1e045ef0-315b-4de9-819b-4e64180072a0" xlink:type="arc" order="32"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_bdcf9fb3-7cc1-4ee5-87c2-2c1047278038" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_d447b22d-3768-40b4-af62-0ea0e49939ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_d447b22d-3768-40b4-af62-0ea0e49939ff" xlink:type="arc" order="34"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeAssets_e3002d1f-7b96-4aeb-a75f-742ea294ee64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_IncreaseDecreaseInDerivativeAssets_e3002d1f-7b96-4aeb-a75f-742ea294ee64" xlink:type="arc" order="35"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities_b6b84b0c-2e42-419a-b974-51658de6a281" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities_b6b84b0c-2e42-419a-b974-51658de6a281" xlink:type="arc" order="36"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="extended" id="i4ddf8995f353426ba7501d87dc4f3da1_fc58a049-28e4-4c5f-89fb-e596e38e74f4">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_c9569367-33e4-41ba-b730-e233f838e324_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_c9569367-33e4-41ba-b730-e233f838e324_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_ec177813-18b5-4bac-8fae-02483b36730d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_ec177813-18b5-4bac-8fae-02483b36730d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:to="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_290748d6-7852-4d2f-9d38-26429580db90" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_290748d6-7852-4d2f-9d38-26429580db90" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_a2eb02e7-1096-4838-bbb1-27c2c3e15d95" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_a2eb02e7-1096-4838-bbb1-27c2c3e15d95" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_7bdf130e-16e4-496a-bcd9-ab77e7bd65ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_7bdf130e-16e4-496a-bcd9-ab77e7bd65ca" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_4cfa4dfe-013e-4029-92f2-9b4f1dab7bd9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_4cfa4dfe-013e-4029-92f2-9b4f1dab7bd9" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_88f52c73-6a58-41f9-8855-b27c8ad1e1a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesPayableCurrent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_NotesPayableCurrent_88f52c73-6a58-41f9-8855-b27c8ad1e1a1" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermNotesPayable_e441357c-9cea-4a0a-94e5-20a0cac3192e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermNotesPayable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_LongTermNotesPayable_e441357c-9cea-4a0a-94e5-20a0cac3192e" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_9d4157ca-0b0d-4bea-b45e-9dbc59459801" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_9d4157ca-0b0d-4bea-b45e-9dbc59459801" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_26f10dd5-15de-4c0f-b2e6-a97b7c0c018f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_26f10dd5-15de-4c0f-b2e6-a97b7c0c018f" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="extended" id="iabaa3208c4ac4d4abc4e08016377af30_4d018432-d2fa-4ae4-bd06-c64859dd79d8"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="extended" id="if3788542500b482ba2186792995280ec_7e53ac63-5da1-4583-9d58-97897e65c5b6"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsInvestmentCategoriesDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="extended" id="i5642152e728246b4a47f808e5a084988_876ec5ab-9319-4d3c-8906-44bbd97e3e90">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:to="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_330e00f1-7e93-4eef-9f7b-917e416c4e6b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_330e00f1-7e93-4eef-9f7b-917e416c4e6b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DemandDepositsMember_9c28bc3b-27ac-4d66-9c25-662bb0bafe68" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DemandDepositsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_DemandDepositsMember_9c28bc3b-27ac-4d66-9c25-662bb0bafe68" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_c33bc703-14b4-4890-ac56-91f95dbc2283" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_c33bc703-14b4-4890-ac56-91f95dbc2283" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember_031abb46-a063-4ee8-bab1-40b403843c9d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_EquitySecuritiesMember_031abb46-a063-4ee8-bab1-40b403843c9d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_1198f7a1-2394-43f1-832a-d6bf849ce48a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_CommercialPaperMember_1198f7a1-2394-43f1-832a-d6bf849ce48a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b0ffa393-20a8-4d3c-bb40-e42c95efefcb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b0ffa393-20a8-4d3c-bb40-e42c95efefcb" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_a9fb6df8-7048-4525-b632-668e8b5d007e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_a9fb6df8-7048-4525-b632-668e8b5d007e" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalBondsMember_c3d1f820-1722-48a1-8861-2fb9855474db" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MunicipalBondsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_MunicipalBondsMember_c3d1f820-1722-48a1-8861-2fb9855474db" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d0094685-d442-465a-8997-5350c3fa7df2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d0094685-d442-465a-8997-5350c3fa7df2" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee3f2178-4be7-48d5-9b52-2c3939e5a7ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee3f2178-4be7-48d5-9b52-2c3939e5a7ff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_34e862a7-a941-4439-821d-ccdbf81c7191" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_34e862a7-a941-4439-821d-ccdbf81c7191" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9339e7df-4da4-4078-951e-3432f25fb5a2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9339e7df-4da4-4078-951e-3432f25fb5a2" xlink:type="arc" order="4"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsOtherCurrentAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="extended" id="i1cf6ac9ac3824952947fe3726dd4b0ad_2f75c723-e1b8-4968-8728-cc6fb9bfc2e7"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsPropertyandEquipmentDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="extended" id="i24d4543d118f4dd1a216124c2a4b6f59_ce57561a-b062-4ea5-888a-025de9ac3c3f">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:to="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_5e252fdd-895a-416f-915f-fe84c35ffccd_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:to="loc_srt_RangeMember_5e252fdd-895a-416f-915f-fe84c35ffccd_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:to="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_67419d5b-cee8-4899-be85-b74ceafe61a6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:to="loc_srt_MinimumMember_67419d5b-cee8-4899-be85-b74ceafe61a6" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6f40db86-ff53-4f6e-a63a-f59484093830" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:to="loc_srt_MaximumMember_6f40db86-ff53-4f6e-a63a-f59484093830" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_99660123-d176-4931-b07a-d9e17bb51de7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_99660123-d176-4931-b07a-d9e17bb51de7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_40ff1e44-4c0a-43a9-b7d1-48732831aaf9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_us-gaap_OfficeEquipmentMember_40ff1e44-4c0a-43a9-b7d1-48732831aaf9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_d50fe32a-1edf-426e-97bd-4467f293d6b1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_d50fe32a-1edf-426e-97bd-4467f293d6b1" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ComputerEquipmentAndSoftwareMember_6e7c310c-30cb-4348-9272-e8326c8cc0f9" xlink:href="lgnd-20181231.xsd#lgnd_ComputerEquipmentAndSoftwareMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_lgnd_ComputerEquipmentAndSoftwareMember_6e7c310c-30cb-4348-9272-e8326c8cc0f9" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_61a46231-b337-417f-b450-6ed96a67c7dd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_61a46231-b337-417f-b450-6ed96a67c7dd" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4e52f053-5b59-4625-9589-1968e6032538" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4e52f053-5b59-4625-9589-1968e6032538" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_a1ac148d-c179-458f-bc11-e04a0ed7ced3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_a1ac148d-c179-458f-bc11-e04a0ed7ced3" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_e4e1e0c9-1eef-4c75-93a4-d81dc0b2b62a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_e4e1e0c9-1eef-4c75-93a4-d81dc0b2b62a" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_996416df-38c1-44d2-b16e-7e918d2861f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Depreciation"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_Depreciation_996416df-38c1-44d2-b16e-7e918d2861f4" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="extended" id="ide2648a196984a8d8c4c152b5cbc741b_5ca23b49-02f1-4083-9f01-0751c25dc91c">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember_0cda7486-84c1-403e-b897-8f76c99fa49a" xlink:href="lgnd-20181231.xsd#lgnd_AcquiredInProcessResearchAndDevelopmentMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:to="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember_0cda7486-84c1-403e-b897-8f76c99fa49a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentedTechnologyMember_8923c2a0-654b-439a-82f6-84650cf5c128" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PatentedTechnologyMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_PatentedTechnologyMember_8923c2a0-654b-439a-82f6-84650cf5c128" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_44d58154-73d0-4e8d-88ac-a803075d8d13" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradeNamesMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_TradeNamesMember_44d58154-73d0-4e8d-88ac-a803075d8d13" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_4e0fcbcb-c09c-459f-a9c2-435386b8f878" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_CustomerRelationshipsMember_4e0fcbcb-c09c-459f-a9c2-435386b8f878" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_628f01a5-7eba-4c47-9c32-73577ecfdeb9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_628f01a5-7eba-4c47-9c32-73577ecfdeb9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5be6d4c6-5d95-4345-a167-c987b59ea181" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_Goodwill_5be6d4c6-5d95-4345-a167-c987b59ea181" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6b96d811-403d-4bbf-ba48-637882d01419" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6b96d811-403d-4bbf-ba48-637882d01419" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_acc2ea11-425e-40b1-8cbc-cf48aea50ada" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_acc2ea11-425e-40b1-8cbc-cf48aea50ada" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_f3547410-6bf8-4772-bcea-284ec236f8f2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_f3547410-6bf8-4772-bcea-284ec236f8f2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d9c1d1da-ede5-4e54-add5-ffee97c456af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d9c1d1da-ede5-4e54-add5-ffee97c456af" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_44a7eac8-7758-483a-9724-1493176368ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_44a7eac8-7758-483a-9724-1493176368ee" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a1af3442-3b99-4894-acc4-da7e85cfa29c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a1af3442-3b99-4894-acc4-da7e85cfa29c" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_ca159088-3f22-4eb8-8d61-ee51648e25a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_ca159088-3f22-4eb8-8d61-ee51648e25a1" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_2d977ba5-432c-4b2a-9592-18d37f516f69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_2d977ba5-432c-4b2a-9592-18d37f516f69" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3ce22fd-b5ca-444a-a1a9-b66c63247ebe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3ce22fd-b5ca-444a-a1a9-b66c63247ebe" xlink:type="arc" order="11"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_c64ca83e-abd6-44c4-8886-61f2a2cd8cb8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_c64ca83e-abd6-44c4-8886-61f2a2cd8cb8" xlink:type="arc" order="12"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c80ef063-c0fb-4c06-b988-077e36f19c86" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c80ef063-c0fb-4c06-b988-077e36f19c86" xlink:type="arc" order="13"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsAccruedLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="extended" id="ieead2d1b2a1046ce8f441d7dda3d99ba_3a6196d3-f849-47ba-9b8e-f04e2d07daf3"/>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsContingentLiabilitiesDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="extended" id="i58e80036104444058f53faabd67e809f_3e7e539d-9208-49c1-af58-1f6952162024">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexPharmaceuticalsIncMember_d8dd2160-2822-4778-bca4-05c30dea2cbe" xlink:href="lgnd-20181231.xsd#lgnd_CydexPharmaceuticalsIncMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_CydexPharmaceuticalsIncMember_d8dd2160-2822-4778-bca4-05c30dea2cbe" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MetabasisTherapeuticsMember_856eafe2-b40d-4738-b0c9-70dfd26ff292" xlink:href="lgnd-20181231.xsd#lgnd_MetabasisTherapeuticsMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_MetabasisTherapeuticsMember_856eafe2-b40d-4738-b0c9-70dfd26ff292" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_d49007f1-6047-40ac-8934-3e42a8a6fc9f" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_CrystalMember_d49007f1-6047-40ac-8934-3e42a8a6fc9f" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_87d197b5-a170-448a-9f0a-b7a672c5e36f" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_87d197b5-a170-448a-9f0a-b7a672c5e36f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_9606b558-3884-4502-818f-e87edfcf4490" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_9606b558-3884-4502-818f-e87edfcf4490" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_d045e97f-6ed2-43ad-ab84-65eab0e0b581" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_d045e97f-6ed2-43ad-ab84-65eab0e0b581" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_c30cf4c6-0258-4e69-b7cd-0612140705f4" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_c30cf4c6-0258-4e69-b7cd-0612140705f4" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:href="lgnd-20181231.xsd#lgnd_ContingentLiabilityRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_42071e80-e8fa-4fc7-ba07-5aa75d94d949" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_42071e80-e8fa-4fc7-ba07-5aa75d94d949" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHolders_e2ade7f6-cb40-4d30-9948-c725228f1a3a" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHolders"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_PaymentsToContingentValueRightHolders_e2ade7f6-cb40-4d30-9948-c725228f1a3a" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_ee48a2be-c887-48d3-a7b9-152a8451f5ce" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_ee48a2be-c887-48d3-a7b9-152a8451f5ce" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_efcddd01-70f6-470c-bfed-3319a8e1f7e8" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_efcddd01-70f6-470c-bfed-3319a8e1f7e8" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_16532a00-17be-4ffd-baf7-16fb3ad4eba8" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquity" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquity"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquity" xlink:type="extended" id="ia9a09f08c4b4414abfde6c9b3edb80c8_0aaeeb29-ff2c-49c8-a38b-495b58b038cf"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="extended" id="i486f1416e76b46c19e34edc3837a893c_c69fadac-61ba-4fec-8c4d-1cb24f7dd509"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended" id="i9ae66bda423246ab892d204866a03301_2f5a6b74-f8fb-442d-8803-d623ffabe425">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_5fba2b04-163e-42ff-8b14-60272feaa2c7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_5fba2b04-163e-42ff-8b14-60272feaa2c7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_cc049171-8809-4bc1-a148-4182cf23b650" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:to="loc_us-gaap_SubsequentEventMember_cc049171-8809-4bc1-a148-4182cf23b650" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_be60f7e0-8b8c-4eaa-b080-95345767b0af_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:to="loc_us-gaap_PlanNameDomain_be60f7e0-8b8c-4eaa-b080-95345767b0af_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:to="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_08c550c3-4357-4354-ac8e-cc05ab8d2240" xlink:href="lgnd-20181231.xsd#lgnd_TwoThousandTwoStockIncentivePlanMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:to="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_08c550c3-4357-4354-ac8e-cc05ab8d2240" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AmendedESPPMember_6cad393f-c687-4145-a878-3bca192e0831" xlink:href="lgnd-20181231.xsd#lgnd_AmendedESPPMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:to="loc_lgnd_AmendedESPPMember_6cad393f-c687-4145-a878-3bca192e0831" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_17c23e32-2817-48e8-b5ec-e23c0a865a4b_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_17c23e32-2817-48e8-b5ec-e23c0a865a4b_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_d2f12fcb-75b2-48a8-9281-cee08b1e6468" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:to="loc_us-gaap_EmployeeStockOptionMember_d2f12fcb-75b2-48a8-9281-cee08b1e6468" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_0084247f-e782-43f0-ae5f-44970efc80bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:to="loc_us-gaap_RestrictedStockMember_0084247f-e782-43f0-ae5f-44970efc80bb" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_c2069988-fe7e-46d6-ba3c-c0f8e09399ea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_c2069988-fe7e-46d6-ba3c-c0f8e09399ea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_67bc1e0f-f841-4e1d-ba2e-8221acdb883c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_67bc1e0f-f841-4e1d-ba2e-8221acdb883c" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_62f113ab-d491-435d-8749-4456a87cd606" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_62f113ab-d491-435d-8749-4456a87cd606" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_4ff11fe4-480a-4641-9736-633f81b90123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_4ff11fe4-480a-4641-9736-633f81b90123" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_839fa8cc-f4bc-4c1e-a988-2d235afd04ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_839fa8cc-f4bc-4c1e-a988-2d235afd04ee" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_f1cd06b7-a8f7-474a-b113-6306004bf0b4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_f1cd06b7-a8f7-474a-b113-6306004bf0b4" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bdadce86-ddca-4481-b5c0-0e37c9e8bb3c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bdadce86-ddca-4481-b5c0-0e37c9e8bb3c" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_eb96feed-33e7-4433-9f8d-1bfeef1bbe64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_eb96feed-33e7-4433-9f8d-1bfeef1bbe64" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:href="lgnd-20181231.xsd#lgnd_EmployeeStockPurchasePlanAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_7e4dafd7-c153-4a50-8cf6-830c15fc3096" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_7e4dafd7-c153-4a50-8cf6-830c15fc3096" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_747ae42a-4b1c-4acf-99dc-a81caae3a7c3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_747ae42a-4b1c-4acf-99dc-a81caae3a7c3" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:href="lgnd-20181231.xsd#lgnd_CorporateShareRepurchaseAbstract"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_0d13c2dc-f393-43f7-81df-7be74e02133f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_0d13c2dc-f393-43f7-81df-7be74e02133f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_3371547c-b880-4143-80b8-1647453a1272" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_3371547c-b880-4143-80b8-1647453a1272" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_2e6ee8fd-5ab2-4c10-a17c-26677ddd740d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_2e6ee8fd-5ab2-4c10-a17c-26677ddd740d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_95c91410-328a-47ca-a3f7-c68299cdd237" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_95c91410-328a-47ca-a3f7-c68299cdd237" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramPeriodInForce1_889d9d0c-1008-4661-9452-0a5e53a34ad2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramPeriodInForce1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramPeriodInForce1_889d9d0c-1008-4661-9452-0a5e53a34ad2" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_cd0a97d6-2316-47d2-aa55-19e45a8fe806" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_cd0a97d6-2316-47d2-aa55-19e45a8fe806" xlink:type="arc" order="6"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityShareBasedCompensationDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="extended" id="i4b43c8b7fc484c6f94b594b4fc409ce1_c912744d-b7a9-4fba-9e2d-40c2da13995a">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_7734950a-b819-4819-900c-2574fb57db7a_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_7734950a-b819-4819-900c-2574fb57db7a_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d22d8bd7-7e09-4b21-a21b-ea1f20db65b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d22d8bd7-7e09-4b21-a21b-ea1f20db65b8" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bc7a0aff-14de-4340-a35e-a306405c89ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bc7a0aff-14de-4340-a35e-a306405c89ff" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_9a2d80d8-feb9-4fd5-b860-493ff0437e99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_9a2d80d8-feb9-4fd5-b860-493ff0437e99" xlink:type="arc" order="1"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityStockOptionPlanActivityDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="extended" id="id140c033fb914569974971dbd889ebbc_e2f2188d-e466-4a00-8b50-341885664b80"/>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityBreakdownofOptionsOutstandingDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="extended" id="ib53bc88dbce44281aaf14314eabc96d6_4e60ae64-1a4c-4197-b2db-803a115a20d8">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeElevenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:to="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeOneMember_eb45da41-33f3-48a4-adee-e8b8bb812c9f" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeOneMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeOneMember_eb45da41-33f3-48a4-adee-e8b8bb812c9f" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTwoMember_2debba52-c33a-46c1-a497-478186ea25a2" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTwoMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeTwoMember_2debba52-c33a-46c1-a497-478186ea25a2" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeThreeMember_7ddf03ba-5e11-4212-86e9-c2a64766065d" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeThreeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeThreeMember_7ddf03ba-5e11-4212-86e9-c2a64766065d" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFourMember_4fb199f1-991f-40f4-9c72-513d6b1c6543" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFourMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeFourMember_4fb199f1-991f-40f4-9c72-513d6b1c6543" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFiveMember_0c0676b4-3597-4b8a-af58-46a09be16bd4" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFiveMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeFiveMember_0c0676b4-3597-4b8a-af58-46a09be16bd4" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSixMember_99bd035f-d493-4faf-9755-f2e2da7707d7" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSixMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeSixMember_99bd035f-d493-4faf-9755-f2e2da7707d7" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSevenMember_499c3f07-c174-4869-a36f-b71d753758b3" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSevenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeSevenMember_499c3f07-c174-4869-a36f-b71d753758b3" xlink:type="arc" order="7"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeNineMember_f7c1c8c8-6462-4e82-8e1a-5de21ae38834" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeNineMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeNineMember_f7c1c8c8-6462-4e82-8e1a-5de21ae38834" xlink:type="arc" order="8"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTenMember_61af9fab-7226-49e4-88d4-4b4fcb2b02f7" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTenMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeTenMember_61af9fab-7226-49e4-88d4-4b4fcb2b02f7" xlink:type="arc" order="9"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeEightMember_44f85ca7-81ef-4aa7-b1f3-6063ca488ad4" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeEightMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeEightMember_44f85ca7-81ef-4aa7-b1f3-6063ca488ad4" xlink:type="arc" order="10"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_58fb6c7f-f445-4403-9a8c-3a91902d5be7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_58fb6c7f-f445-4403-9a8c-3a91902d5be7" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_bb3a7594-a8bd-420e-82de-fdc81f457d42" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_bb3a7594-a8bd-420e-82de-fdc81f457d42" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_747c884f-2e25-42e4-8bab-901dd9827d59" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_747c884f-2e25-42e4-8bab-901dd9827d59" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_ec97dde9-0db0-4ee4-bb85-6c03168a4119" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_ec97dde9-0db0-4ee4-bb85-6c03168a4119" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_32cfa971-c05c-4948-8b74-9749e94d3c04" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_32cfa971-c05c-4948-8b74-9749e94d3c04" xlink:type="arc" order="5"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_5baeb87a-22f8-48f6-9063-8dede27f4cd5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_5baeb87a-22f8-48f6-9063-8dede27f4cd5" xlink:type="arc" order="6"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_339e76b0-5078-4080-b8c8-b5a579fd9de3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_339e76b0-5078-4080-b8c8-b5a579fd9de3" xlink:type="arc" order="7"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityAssumptionsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="extended" id="i6f18e0cd686f4b02aac978cc0d97b24e_7f12bb75-089c-4ed1-ba00-6aaf26f1d8b3">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:to="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c_default" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:to="loc_srt_RangeMember_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:to="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_247bb733-53fd-4101-b922-b9d9e44b15a9" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:to="loc_srt_MinimumMember_247bb733-53fd-4101-b922-b9d9e44b15a9" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_799c4478-7381-4f64-b606-9db77eecf010" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:to="loc_srt_MaximumMember_799c4478-7381-4f64-b606-9db77eecf010" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e3d9c2bd-060b-40de-8ab0-e123676b0927" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e3d9c2bd-060b-40de-8ab0-e123676b0927" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6dc8284b-b682-47af-9ffb-5c5fb2151929" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6dc8284b-b682-47af-9ffb-5c5fb2151929" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ba910226-25f2-4336-bf0c-7a7ef5a19b31" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ba910226-25f2-4336-bf0c-7a7ef5a19b31" xlink:type="arc" order="3"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityRestrictedStockActivityDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="extended" id="i21e75bbe0a4b45d18bdd2868cf8a0b69_fe5e417f-2644-4c27-a309-6d379fa0163a">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:to="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5070a118-0a5b-465e-87d9-a925ce827505_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_5070a118-0a5b-465e-87d9-a925ce827505_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_940fbb54-31a8-4354-9a6b-4d8228d5f380" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:to="loc_us-gaap_RestrictedStockMember_940fbb54-31a8-4354-9a6b-4d8228d5f380" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38d57b2d-1d71-4c33-b62c-e971157ee83e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38d57b2d-1d71-4c33-b62c-e971157ee83e" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_98b80bd0-b50c-4a58-a049-d493878b0ad8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_98b80bd0-b50c-4a58-a049-d493878b0ad8" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_7635d218-1f84-4602-a089-a7476122960a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_7635d218-1f84-4602-a089-a7476122960a" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_d53886f1-0548-4c49-b4a3-578528c15364" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_d53886f1-0548-4c49-b4a3-578528c15364" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d2c28728-6afb-4a48-a966-15dce369ea83" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e68f6c8a-1b89-4149-8996-a63f9b49cc18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e68f6c8a-1b89-4149-8996-a63f9b49cc18" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7b6e6be4-b6bb-441e-9a5f-0f164547be25" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7b6e6be4-b6bb-441e-9a5f-0f164547be25" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_b01c6716-d7d5-4d89-b740-f8f022a4d1ea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_b01c6716-d7d5-4d89-b740-f8f022a4d1ea" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_c06fe0d1-a17d-47fd-8851-e84cca3663c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_c06fe0d1-a17d-47fd-8851-e84cca3663c5" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_31bd0f0c-2ff5-4060-91bd-6d15ec43feca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CommitmentsandContingenciesLegalProceedings"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="extended" id="ic11efae4ea60454d8f2b1fd1616334d1_397d6fca-14ab-461c-af2d-c9a60f2381ae"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxes"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxes" xlink:type="extended" id="i50561d64178a4995b9e46e236cedc082_ef79b187-0c42-4b0c-9c80-fc48c4127285"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="extended" id="i343e2de5568e47c1ba99d10bfc110670_2b960d4a-7095-4be2-802a-4d6d9f71712d"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended" id="i3425328c4ad24cce8c5a44f0b3ea73a1_acc70aa2-6311-474e-9315-01ec1d20a133">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/all" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:type="arc" order="1" xbrldt:closed="true" xbrldt:contextElement="segment"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_5b3c0db2-e888-4d3a-89c2-c9678eab0a02_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_5b3c0db2-e888-4d3a-89c2-c9678eab0a02_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_7a72e856-d986-45a0-b1c9-b8385b215102" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_7a72e856-d986-45a0-b1c9-b8385b215102" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_c84cb97d-fe91-4adf-a35d-b4130a1b6295" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_c84cb97d-fe91-4adf-a35d-b4130a1b6295" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/hypercube-dimension" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_0fb5c98e-8efb-4aa7-9a31-726942c34bd7_default" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-default" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_0fb5c98e-8efb-4aa7-9a31-726942c34bd7_default" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/dimension-domain" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchMember_b12f76d6-b1a8-4654-a511-57bf2049cbec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:to="loc_us-gaap_ResearchMember_b12f76d6-b1a8-4654-a511-57bf2049cbec" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_d58de77d-723c-4ca3-9ff6-021463286742" xlink:href="lgnd-20181231.xsd#lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:to="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_d58de77d-723c-4ca3-9ff6-021463286742" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_683ee185-ce2f-4860-a914-2243851ccddb" xlink:href="lgnd-20181231.xsd#lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_683ee185-ce2f-4860-a914-2243851ccddb" xlink:type="arc" order="1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_6bad2dce-d194-42be-9aa0-66d90592701b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_6bad2dce-d194-42be-9aa0-66d90592701b" xlink:type="arc" order="2"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_be58294f-6aa1-4964-9ffb-d95cb8cc9ab8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_OperatingLossCarryforwards_be58294f-6aa1-4964-9ffb-d95cb8cc9ab8" xlink:type="arc" order="3"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_791838bd-2a5b-44c0-8306-9b43ba2fb852" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_791838bd-2a5b-44c0-8306-9b43ba2fb852" xlink:type="arc" order="4"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_a531ec9d-376d-47e6-90f2-1fe6d5301f20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate"/>
    <link:definitionArc xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_a531ec9d-376d-47e6-90f2-1fe6d5301f20" xlink:type="arc" order="5"/>
  </link:definitionLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="extended" id="i261e30a8a916486eb0eba72ea14bd0fd_705b043f-e381-474f-9ee1-a59983760e50"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="extended" id="i7f7d547db2df4c23ae12f3adf2368657_1d68715a-9f5c-4134-bb25-02b8d613573a"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesDeferredTaxesDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="extended" id="i2781842d11874acbbeeedcedb7ced0b4_ee3a206e-90e5-429e-9da5-5cb95efe4ab0"/>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="extended" id="i1fdd077c96e74778ac5bef80df096b20_b91d0ef4-4319-4fe6-855b-28ac75110643"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformation"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="extended" id="ifc864e063bad4746a9f6a6ea96b9bd5a_572d6dac-9414-4356-b19a-3f28d586240f"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationTables"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="extended" id="i9e72f1a7b5cf46bd9a68e982f690e2d6_8cf2d416-0593-4226-8673-adc7e225cdc1"/>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"/>
  <link:definitionLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="extended" id="ia2a8449be57b447fbdc326161258d13e_a5aeae73-cf5b-44ff-8dc5-f4ccb67b3f9b"/>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>11
<FILENAME>lgnd-20181231_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2017 Workiva-->
<!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel"/>
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_ae8ea659-2191-4841-9c2f-5f04be34f506_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, par value (USD per share)</link:label>
    <link:label id="lab_us-gaap_CommonStockParOrStatedValuePerShare_label_en-US" xlink:label="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Par or Stated Value Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockParOrStatedValuePerShare" xlink:to="lab_us-gaap_CommonStockParOrStatedValuePerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_b7ccf025-648d-444c-a367-a0959ff521ac_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred income taxes</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Deferred Income Taxes</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:to="lab_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_8e8ae5c0-8fd3-41d1-b605-32efd09bbd2c_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from commercial license rights</link:label>
    <link:label id="lab_us-gaap_ProceedsFromLicenseFeesReceived_label_en-US" xlink:label="lab_us-gaap_ProceedsFromLicenseFeesReceived" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from License Fees Received</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromLicenseFeesReceived" xlink:to="lab_us-gaap_ProceedsFromLicenseFeesReceived" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_7866906b-9f49-49f6-bd38-35441531de67_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Investment Categories</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:to="lab_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_6caf871a-b1e2-4d11-9f5a-da90b17c84f2_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition, Acquiree [Domain]</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionAcquireeDomain_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAcquireeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition, Acquiree [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain" xlink:to="lab_us-gaap_BusinessAcquisitionAcquireeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CydexandCrystalMember_815157cb-d19f-4918-bb61-401b5481485c_terseLabel_en-US" xlink:label="lab_lgnd_CydexandCrystalMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex and Crystal</link:label>
    <link:label id="lab_lgnd_CydexandCrystalMember_label_en-US" xlink:label="lab_lgnd_CydexandCrystalMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex and Crystal [Member]</link:label>
    <link:label id="lab_lgnd_CydexandCrystalMember_documentation_en-US" xlink:label="lab_lgnd_CydexandCrystalMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex and Crystal [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexandCrystalMember" xlink:href="lgnd-20181231.xsd#lgnd_CydexandCrystalMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CydexandCrystalMember" xlink:to="lab_lgnd_CydexandCrystalMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAbstract_58c720e8-26ba-49b1-87a2-86b81ff7ecf9_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basic per share amounts:</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAbstract_c20f4c17-4f3f-4bd4-9d94-a464efa15910_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basic per share amounts:</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAbstract_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Basic [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract" xlink:to="lab_us-gaap_EarningsPerShareBasicAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_LegalEntityAxis_7ded07eb-7add-4309-a2f3-e86102098f76_terseLabel_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:label id="lab_dei_LegalEntityAxis_label_en-US" xlink:label="lab_dei_LegalEntityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal Entity [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LegalEntityAxis" xlink:to="lab_dei_LegalEntityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_530ec99e-9d32-4015-b0a4-429aa0b3db35_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Type [Domain]</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskTypeDomain_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain" xlink:to="lab_us-gaap_ConcentrationRiskTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_a1829ce1-bea3-42d5-a480-b544ed2b3a65_terseLabel_en-US" xlink:label="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of consideration received for repayment of convertible notes</link:label>
    <link:label id="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_label_en-US" xlink:label="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Significant Noncash Transaction, Value of Consideration Received</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:to="lab_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VikingTherapeuticsInc.Member_5473a032-50f1-44bb-8bfe-72b3b56653f3_terseLabel_en-US" xlink:label="lab_lgnd_VikingTherapeuticsInc.Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Viking Therapeutics, Inc.</link:label>
    <link:label id="lab_lgnd_VikingTherapeuticsInc.Member_label_en-US" xlink:label="lab_lgnd_VikingTherapeuticsInc.Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Viking Therapeutics, Inc. [Member]</link:label>
    <link:label id="lab_lgnd_VikingTherapeuticsInc.Member_documentation_en-US" xlink:label="lab_lgnd_VikingTherapeuticsInc.Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Viking Therapeutics, Inc. [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VikingTherapeuticsInc.Member" xlink:to="lab_lgnd_VikingTherapeuticsInc.Member" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeFiveMember_26f20169-707e-4513-a47d-a52cf72dde11_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFiveMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$21.92 - $21.92</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeFiveMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFiveMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Five [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeFiveMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFiveMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Five [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFiveMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFiveMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeFiveMember" xlink:to="lab_lgnd_ExercisePriceRangeFiveMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_0f79f842-3fe5-40b1-9731-8339477e588f_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants issued in public offering (shares)</link:label>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Warrant or Right, Number of Securities Called by Warrants or Rights</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:to="lab_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PurchaseOfConvertibleBondHedge_03cb385f-018b-4773-9843-cd96a75fc8b5_negatedLabel_en-US" xlink:label="lab_lgnd_PurchaseOfConvertibleBondHedge" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of convertible bond hedge</link:label>
    <link:label id="lab_lgnd_PurchaseOfConvertibleBondHedge_label_en-US" xlink:label="lab_lgnd_PurchaseOfConvertibleBondHedge" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of Convertible Bond Hedge</link:label>
    <link:label id="lab_lgnd_PurchaseOfConvertibleBondHedge_documentation_en-US" xlink:label="lab_lgnd_PurchaseOfConvertibleBondHedge" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of Convertible Bond Hedge</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseOfConvertibleBondHedge" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseOfConvertibleBondHedge"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PurchaseOfConvertibleBondHedge" xlink:to="lab_lgnd_PurchaseOfConvertibleBondHedge" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Depreciation_bbfaf5d7-c6ed-4d89-9009-700c640a9172_verboseLabel_en-US" xlink:label="lab_us-gaap_Depreciation" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depreciation expense</link:label>
    <link:label id="lab_us-gaap_Depreciation_label_en-US" xlink:label="lab_us-gaap_Depreciation" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depreciation</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Depreciation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Depreciation" xlink:to="lab_us-gaap_Depreciation" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_3adcbd35-ad03-47c7-86c9-ab893482c430_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options outstanding (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_ff552917-9c52-4c40-afb8-4966277013cd_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Prepaid expenses and other current assets</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Prepaid Expense and Other Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_3e841c72-4aec-4e6d-bdfa-cd9f2580783d_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Exercise Price [Roll Forward]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_109f3089-81f0-41b7-9d0a-890b90771ecf_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Type [Axis]</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskByTypeAxis_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis" xlink:to="lab_us-gaap_ConcentrationRiskByTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock_e5eb409b-65a3-4a17-bd87-50431c698496_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Unrecognized Tax Benefits</link:label>
    <link:label id="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns Roll Forward [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MaterialSalesCaptisolMember_73b7e4fe-fc2d-41b7-9d14-df9d7feae308_terseLabel_en-US" xlink:label="lab_lgnd_MaterialSalesCaptisolMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Material sales</link:label>
    <link:label id="lab_lgnd_MaterialSalesCaptisolMember_label_en-US" xlink:label="lab_lgnd_MaterialSalesCaptisolMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Material Sales, Captisol [Member]</link:label>
    <link:label id="lab_lgnd_MaterialSalesCaptisolMember_documentation_en-US" xlink:label="lab_lgnd_MaterialSalesCaptisolMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Material Sales, Captisol [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaterialSalesCaptisolMember" xlink:href="lgnd-20181231.xsd#lgnd_MaterialSalesCaptisolMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MaterialSalesCaptisolMember" xlink:to="lab_lgnd_MaterialSalesCaptisolMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_6d48d7d3-0431-401a-9e88-f0502aff66e5_verboseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercisable, Aggregate Intrinsic Value</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_4b0c72b7-9a76-4bd9-8cbe-7483436edcf8_terseLabel_en-US" xlink:label="lab_us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue recognized</link:label>
    <link:label id="lab_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_label_en-US" xlink:label="lab_us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contract with Customer, Liability, Revenue Recognized</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:to="lab_us-gaap_ContractWithCustomerLiabilityRevenueRecognized" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_WarrantsCurrent_9efce631-55ce-4101-8baf-0ed58720fbc3_terseLabel_en-US" xlink:label="lab_lgnd_WarrantsCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking warrants</link:label>
    <link:label id="lab_lgnd_WarrantsCurrent_label_en-US" xlink:label="lab_lgnd_WarrantsCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants, Current</link:label>
    <link:label id="lab_lgnd_WarrantsCurrent_documentation_en-US" xlink:label="lab_lgnd_WarrantsCurrent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsCurrent" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_WarrantsCurrent" xlink:to="lab_lgnd_WarrantsCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LeaseAndRentalExpense_0022186b-b392-44a3-84ea-da629a7b8eb0_terseLabel_en-US" xlink:label="lab_us-gaap_LeaseAndRentalExpense" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Rent expense</link:label>
    <link:label id="lab_us-gaap_LeaseAndRentalExpense_label_en-US" xlink:label="lab_us-gaap_LeaseAndRentalExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Rent Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseAndRentalExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseAndRentalExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeaseAndRentalExpense" xlink:to="lab_us-gaap_LeaseAndRentalExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_6df8c938-4f8b-47fe-aac0-f6e0981cf747_verboseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and equipment, net</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_407aa8b7-2789-4e89-a364-caa318a384d7_totalLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and equipment, net</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentNet_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_957d4a47-9aca-41c6-b9d8-bf3ee631585f_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate Intrinsic Value</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_c62d57b7-7eee-439f-8079-813309e9fce0_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentAxis_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentAxis" xlink:to="lab_us-gaap_DebtInstrumentAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_93402ab3-a630-48e0-a84a-1ef2fc469502_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Significant Other Observable Inputs (Level 2)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel2Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel2Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Inputs, Level 2 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel2Member" xlink:to="lab_us-gaap_FairValueInputsLevel2Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_806aafdd-10a3-4021-89e5-8cc76c5e2f93_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vested (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_7ec9b358-1aee-411f-9b84-2d6b720f9b80_terseLabel_en-US" xlink:label="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">California and New Jersey Research Tax Credit Carryforward</link:label>
    <link:label id="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_label_en-US" xlink:label="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">California and New Jersey Research Tax Credit Carryforward [Member]</link:label>
    <link:label id="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_documentation_en-US" xlink:label="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">California and New Jersey Research Tax Credit Carryforward [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:href="lgnd-20181231.xsd#lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:to="lab_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeStockOptionMember_fb7d4247-8c10-4c6e-b672-d10949d5e066_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeStockOptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Options</link:label>
    <link:label id="lab_us-gaap_EmployeeStockOptionMember_label_en-US" xlink:label="lab_us-gaap_EmployeeStockOptionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock Option [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeStockOptionMember" xlink:to="lab_us-gaap_EmployeeStockOptionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_fb5cb73c-1627-4e28-9daa-e716fef35184_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options vested and expected to vest at end of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_stpr_CA_49a3d6bf-0797-4f09-b762-d9e17aae5983_terseLabel_en-US" xlink:label="lab_stpr_CA" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">California</link:label>
    <link:label id="lab_stpr_CA_label_en-US" xlink:label="lab_stpr_CA" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CALIFORNIA</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_CA" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_CA"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_stpr_CA" xlink:to="lab_stpr_CA" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_d9a28ff8-5a03-44db-be2f-fbede775d630_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares allowed to purchase in employee stock purchase plan per employee (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_35717812-9cee-4a9f-ae00-303bb32f594f_negatedLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forfeited (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AccruedSalesReturns_eb5ec555-da8a-4187-8008-16d7de56bbf9_terseLabel_en-US" xlink:label="lab_lgnd_AccruedSalesReturns" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Return reserve</link:label>
    <link:label id="lab_lgnd_AccruedSalesReturns_label_en-US" xlink:label="lab_lgnd_AccruedSalesReturns" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Sales Returns</link:label>
    <link:label id="lab_lgnd_AccruedSalesReturns_documentation_en-US" xlink:label="lab_lgnd_AccruedSalesReturns" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Sales Returns</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedSalesReturns" xlink:href="lgnd-20181231.xsd#lgnd_AccruedSalesReturns"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AccruedSalesReturns" xlink:to="lab_lgnd_AccruedSalesReturns" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementTable_210dbb0e-81ab-483c-97db-f8ccc1b37609_terseLabel_en-US" xlink:label="lab_us-gaap_StatementTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Table]</link:label>
    <link:label id="lab_us-gaap_StatementTable_label_en-US" xlink:label="lab_us-gaap_StatementTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementTable" xlink:to="lab_us-gaap_StatementTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_8d9004c7-444b-494e-86b3-f35e89b1efe8_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByMeasurementFrequencyAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Frequency [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:to="lab_us-gaap_FairValueByMeasurementFrequencyAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_c3b7963a-db2a-423f-84ac-708c4a182007_verboseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Changes in operating assets and liabilities, net of acquisition:</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Operating Capital [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:to="lab_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_4fba2f67-2312-4f7e-8572-f511c941c362_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurement</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instruments Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentsDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:to="lab_us-gaap_FinancialInstrumentsDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_b1971af3-2277-433c-8818-1bb942a57501_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares available for future option grants (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_NumberOfContingentValueRightsIssued_96b74738-68c2-4c0a-9938-62deb83ca2c1_terseLabel_en-US" xlink:label="lab_lgnd_NumberOfContingentValueRightsIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of contingent value rights</link:label>
    <link:label id="lab_lgnd_NumberOfContingentValueRightsIssued_label_en-US" xlink:label="lab_lgnd_NumberOfContingentValueRightsIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of Contingent Value Rights Issued</link:label>
    <link:label id="lab_lgnd_NumberOfContingentValueRightsIssued_documentation_en-US" xlink:label="lab_lgnd_NumberOfContingentValueRightsIssued" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of Contingent Value Rights Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberOfContingentValueRightsIssued" xlink:href="lgnd-20181231.xsd#lgnd_NumberOfContingentValueRightsIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_NumberOfContingentValueRightsIssued" xlink:to="lab_lgnd_NumberOfContingentValueRightsIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNiGainLoss_039ac1f8-6597-4926-ab06-da7261e030e0_terseLabel_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNiGainLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (loss) from Viking</link:label>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNiGainLoss_label_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNiGainLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Securities, FV-NI, Gain (Loss)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquitySecuritiesFvNiGainLoss" xlink:to="lab_us-gaap_EquitySecuritiesFvNiGainLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_ea1d4b07-4d1d-449f-9f02-0b2530bc7b67_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accrued Liabilities</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accrued Liabilities [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtDisclosureTextBlock_aa1841a7-7548-4ad4-9385-e8a0336bfe94_terseLabel_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Senior Notes</link:label>
    <link:label id="lab_us-gaap_DebtDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureTextBlock" xlink:to="lab_us-gaap_DebtDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_3f3ef07f-0f6a-4836-a61f-c4c8240566bd_negatedTerseLabel_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in uncertain tax positions</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_label_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Change in Uncertain Tax Positions</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_documentation_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Change in Uncertain Tax Positions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:to="lab_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_1776758a-0c08-4ddd-b1fa-2c6199feaef8_terseLabel_en-US" xlink:label="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Reconciliation of Level 3 Financial Instruments</link:label>
    <link:label id="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_label_en-US" xlink:label="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]</link:label>
    <link:label id="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_documentation_en-US" xlink:label="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:to="lab_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltyPromactaMember_5bffc66f-d041-4690-b43f-c37ec03c6780_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltyPromactaMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Promacta</link:label>
    <link:label id="lab_lgnd_RoyaltyPromactaMember_label_en-US" xlink:label="lab_lgnd_RoyaltyPromactaMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Promacta [Member]</link:label>
    <link:label id="lab_lgnd_RoyaltyPromactaMember_documentation_en-US" xlink:label="lab_lgnd_RoyaltyPromactaMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Promacta</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyPromactaMember" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyPromactaMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltyPromactaMember" xlink:to="lab_lgnd_RoyaltyPromactaMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeSevenMember_f3a3c1cd-6f81-4fe9-9d94-a16b37d428a2_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSevenMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$63.58 - $67.53</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeSevenMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSevenMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Seven [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeSevenMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSevenMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Seven [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSevenMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSevenMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeSevenMember" xlink:to="lab_lgnd_ExercisePriceRangeSevenMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_9c070024-ec2e-4872-9dd9-ad845c586ae5_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other income (expense), net</link:label>
    <link:label id="lab_us-gaap_OtherNonoperatingIncomeExpense_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Nonoperating Income (Expense)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpense" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_c83d5965-1c94-424c-b5b8-7b2460f5a8c7_terseLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sublease payments expected to be received, 3-4 years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in Three and Four Years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in Three and Four Years</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_d440004e-107b-4951-a55a-c6a4dca3b342_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants (shares)</link:label>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Incremental Common Shares Attributable to Dilutive Effect of Call Options and Warrants</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_373008a5-b976-4f9b-83f6-fca7377d1321_terseLabel_en-US" xlink:label="lab_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment, Name [Axis]</link:label>
    <link:label id="lab_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_label_en-US" xlink:label="lab_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment, Name [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:to="lab_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_8008bb74-93c8-4130-b071-8e63a759f7c4_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurements, Recurring and Nonrecurring [Table]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurements, Recurring and Nonrecurring [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TimingOfTransferOfGoodOrServiceDomain_7f08b924-7a20-4fed-8ab6-d1d39b1b1523_terseLabel_en-US" xlink:label="lab_us-gaap_TimingOfTransferOfGoodOrServiceDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Timing of Transfer of Good or Service [Domain]</link:label>
    <link:label id="lab_us-gaap_TimingOfTransferOfGoodOrServiceDomain_label_en-US" xlink:label="lab_us-gaap_TimingOfTransferOfGoodOrServiceDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Timing of Transfer of Good or Service [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain" xlink:to="lab_us-gaap_TimingOfTransferOfGoodOrServiceDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BasisOfPresentationLineItems_c0e3142e-0fc1-4b3c-8507-05510433439c_terseLabel_en-US" xlink:label="lab_lgnd_BasisOfPresentationLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation [Line Items]</link:label>
    <link:label id="lab_lgnd_BasisOfPresentationLineItems_label_en-US" xlink:label="lab_lgnd_BasisOfPresentationLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation [Line Items]</link:label>
    <link:label id="lab_lgnd_BasisOfPresentationLineItems_documentation_en-US" xlink:label="lab_lgnd_BasisOfPresentationLineItems" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of presentation.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationLineItems" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BasisOfPresentationLineItems" xlink:to="lab_lgnd_BasisOfPresentationLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_c7f59570-7ec8-4e94-88af-5eb713ed113e_netLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:role="http://www.xbrl.org/2009/role/netLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basic (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_8dec18ff-3121-4d76-9c82-3ba1e9df7e3a_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted-average common shares outstanding - basic (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_66d4fd36-869a-4df6-b20e-d4f2194fa19b_verboseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average shares&#8212;basic (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Basic</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_28b3a110-b242-4895-b01f-1cb42a8d49c2_totalLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total commercial license rights, net</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsNet_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VestingPeriodOneMember_3b1501e8-e2d8-4c30-bfa7-798f54f427d1_terseLabel_en-US" xlink:label="lab_lgnd_VestingPeriodOneMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vest 1/8 on the six month anniversary of the date of grant</link:label>
    <link:label id="lab_lgnd_VestingPeriodOneMember_label_en-US" xlink:label="lab_lgnd_VestingPeriodOneMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting Period One [Member]</link:label>
    <link:label id="lab_lgnd_VestingPeriodOneMember_documentation_en-US" xlink:label="lab_lgnd_VestingPeriodOneMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting Period One [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodOneMember" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodOneMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VestingPeriodOneMember" xlink:to="lab_lgnd_VestingPeriodOneMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_abb1ba39-71cf-4835-8114-8270b64da314_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk-free interest rate (as a percent)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_79cbfa92-1b41-4b0f-8ee0-3038baf65fd5_terseLabel_en-US" xlink:label="lab_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name of Property [Domain]</link:label>
    <link:label id="lab_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_label_en-US" xlink:label="lab_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name of Property [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:to="lab_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ContractWithCustomerAssetGross_9d293f0e-8386-4983-9961-537d45b1d5f7_terseLabel_en-US" xlink:label="lab_us-gaap_ContractWithCustomerAssetGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross contract asset</link:label>
    <link:label id="lab_us-gaap_ContractWithCustomerAssetGross_label_en-US" xlink:label="lab_us-gaap_ContractWithCustomerAssetGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contract with Customer, Asset, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ContractWithCustomerAssetGross" xlink:to="lab_us-gaap_ContractWithCustomerAssetGross" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLossCarryforwards_a16a1357-8ae5-49d6-b9de-0fdb8e7a1d6c_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating loss carryforward</link:label>
    <link:label id="lab_us-gaap_OperatingLossCarryforwards_label_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Loss Carryforwards</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLossCarryforwards" xlink:to="lab_us-gaap_OperatingLossCarryforwards" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_322f3a7a-cccb-4fa4-a9c0-84d212abd9c0_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense, 2020</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Year Two</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_5e6286c1-4910-484d-b3a2-4eecc53d88e8_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock and warrants in equity method investments</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Equity Method Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:to="lab_us-gaap_PaymentsToAcquireEquityMethodInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsAbstract_67caeb08-c9b4-4ed9-aa05-e1db4bc5e832_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">ASSETS</link:label>
    <link:label id="lab_us-gaap_AssetsAbstract_label_en-US" xlink:label="lab_us-gaap_AssetsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsAbstract" xlink:to="lab_us-gaap_AssetsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentTable_2e5b67bf-22b0-447a-8de4-5bc7312e3b9f_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Long-term Debt Instruments [Table]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentTable_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Long-term Debt Instruments [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentTable" xlink:to="lab_us-gaap_DebtInstrumentTable" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_a1dc8528-5e7a-47ba-8983-6e79a9db088f_terseLabel_en-US" xlink:label="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue royalty payable on all Cydex-related revenue (as a percent)</link:label>
    <link:label id="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_label_en-US" xlink:label="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Royalty to Acquiree Shareholders, Percent</link:label>
    <link:label id="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_documentation_en-US" xlink:label="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Royalty to Acquiree Shareholders, Percent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:to="lab_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_1919a544-6935-48f1-accb-57aab9f44599_verboseLabel_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue_label_en-US" xlink:label="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and Cash Equivalents, at Carrying Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:to="lab_us-gaap_CashAndCashEquivalentsAtCarryingValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsGross_3218b9df-4e27-44f8-b5fb-1328ba2eca3b_totalLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsGross" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred tax assets</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsGross_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsGross" xlink:to="lab_us-gaap_DeferredTaxAssetsGross" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_f196d163-fff9-4e42-9ef3-bad77682eb53_terseLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating leases obligation, 3-4 years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in Three and Four Years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in Three and Four Years</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_59225d6f-149a-4c63-a190-b4dc145f48a4_terseLabel_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (loss) on extinguishment of debt</link:label>
    <link:label id="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt_label_en-US" xlink:label="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (Loss) on Extinguishment of Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:to="lab_us-gaap_GainsLossesOnExtinguishmentOfDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentFiscalYearFocus_0c949589-0715-43a8-aba0-f64e2c123e44_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Fiscal Year Focus</link:label>
    <link:label id="lab_dei_DocumentFiscalYearFocus_label_en-US" xlink:label="lab_dei_DocumentFiscalYearFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Fiscal Year Focus</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalYearFocus"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalYearFocus" xlink:to="lab_dei_DocumentFiscalYearFocus" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeLiabilityMeasurementInput_64ad6471-c5aa-429f-8dcd-cc7abcc7f3c2_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative liability, measurement input</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilityMeasurementInput_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilityMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, Measurement Input</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityMeasurementInput" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilityMeasurementInput"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilityMeasurementInput" xlink:to="lab_us-gaap_DerivativeLiabilityMeasurementInput" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_e45e0570-7083-47e2-ad48-a3791c4f0ac1_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity Note Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:to="lab_us-gaap_StockholdersEquityNoteDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRepurchaseProgramPeriodInForce1_e37722a8-e5c7-4216-b0b5-9584bcfbbfd1_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramPeriodInForce1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock repurchase program, period in force</link:label>
    <link:label id="lab_us-gaap_StockRepurchaseProgramPeriodInForce1_label_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramPeriodInForce1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchase Program, Period in Force</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramPeriodInForce1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramPeriodInForce1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchaseProgramPeriodInForce1" xlink:to="lab_us-gaap_StockRepurchaseProgramPeriodInForce1" xlink:type="arc" order="1"/>
    <link:label id="lab_country_GB_8a30b1b6-cc16-473b-b8cb-298068056731_terseLabel_en-US" xlink:label="lab_country_GB" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">United Kingdom</link:label>
    <link:label id="lab_country_GB_label_en-US" xlink:label="lab_country_GB" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">UNITED KINGDOM</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB" xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_GB"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_country_GB" xlink:to="lab_country_GB" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TitleOfIndividualAxis_97d58cbc-0c01-4ee7-b418-65762f2b7c4c_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:label id="lab_us-gaap_TitleOfIndividualAxis_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of Individual [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualAxis" xlink:to="lab_us-gaap_TitleOfIndividualAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock_49a6f298-698f-465c-a70b-5839c7ff7b45_terseLabel_en-US" xlink:label="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Commercial License Rights</link:label>
    <link:label id="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock_label_en-US" xlink:label="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Commercial License Rights [Table Text Block]</link:label>
    <link:label id="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock_documentation_en-US" xlink:label="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Commercial License Rights [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofCommercialLicenseRightsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:to="lab_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InterestPaidNet_6a11abdd-5145-44df-8cd8-a7f6ba903d15_terseLabel_en-US" xlink:label="lab_us-gaap_InterestPaidNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest paid</link:label>
    <link:label id="lab_us-gaap_InterestPaidNet_label_en-US" xlink:label="lab_us-gaap_InterestPaidNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Paid, Excluding Capitalized Interest, Operating Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestPaidNet" xlink:to="lab_us-gaap_InterestPaidNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubsequentEventTypeDomain_f459ab06-6947-4241-a1d7-a1540bd66c4a_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventTypeDomain_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeDomain" xlink:to="lab_us-gaap_SubsequentEventTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_dcd37474-9899-407b-9a80-1426c1026161_negatedLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts payable and accrued liabilities</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_19a96fda-02fb-4420-adaa-5a479ce98526_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unamortized discount</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedDiscount_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedDiscount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Unamortized Discount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedDiscount" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedDiscount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_83ed8058-9861-4ba8-b1d1-75d4e9959aee_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consideration transferred</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationConsiderationTransferred1_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationConsiderationTransferred1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Consideration Transferred</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1" xlink:to="lab_us-gaap_BusinessCombinationConsiderationTransferred1" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityEmergingGrowthCompany_fe2b620e-de6e-436f-b6e3-2f704a7a8ce6_terseLabel_en-US" xlink:label="lab_dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Emerging Growth Company</link:label>
    <link:label id="lab_dei_EntityEmergingGrowthCompany_label_en-US" xlink:label="lab_dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Emerging Growth Company</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityEmergingGrowthCompany" xlink:to="lab_dei_EntityEmergingGrowthCompany" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RetainedEarningsMember_f08e8642-0b88-4949-95e1-daafc0a20589_terseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated deficit</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsMember_88487114-f3eb-4188-939a-db81c1013653_verboseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retained Earnings</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsMember_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retained Earnings [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsMember" xlink:to="lab_us-gaap_RetainedEarningsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_c931810a-8669-497c-bec0-216044d3b275_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain on sale of Oncology Product Line before income taxes</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operation, Gain (Loss) from Disposal of Discontinued Operation, before Income Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:to="lab_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_22705689-91e5-4bb7-a57d-f18aea6fa303_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash used in investing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_e83ba33e-0d21-4118-92a3-f93f0e1e49a2_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash used in investing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxAuthorityAxis_1bb08030-ec66-46b3-aafa-1436561ba6c9_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Authority [Axis]</link:label>
    <link:label id="lab_us-gaap_IncomeTaxAuthorityAxis_label_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Authority [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis" xlink:to="lab_us-gaap_IncomeTaxAuthorityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_8ae43dae-1070-4f22-89d1-36adb0f91c48_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax expense on discontinued operations</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_f33dd21c-0665-4a56-b320-370c0cec7c30_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Provision for taxes on gain from discontinued operations</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operation, Tax Effect of Gain (Loss) from Disposal of Discontinued Operation</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:to="lab_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CustomerRelationshipsMember_c18ad0f4-4a2d-45e4-84ca-4a4b64d2c487_verboseLabel_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer relationships</link:label>
    <link:label id="lab_us-gaap_CustomerRelationshipsMember_label_en-US" xlink:label="lab_us-gaap_CustomerRelationshipsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer Relationships [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerRelationshipsMember" xlink:to="lab_us-gaap_CustomerRelationshipsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessAcquisitionLineItems_cda243a3-66be-4251-ac95-72a54ffc758d_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition [Line Items]</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionLineItems_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems" xlink:to="lab_us-gaap_BusinessAcquisitionLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_33e7b0c6-cb76-4222-a3f4-4e0a0de21624_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in OMT acquisition (shares)</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Shares, Acquisitions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:to="lab_us-gaap_StockIssuedDuringPeriodSharesAcquisitions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_c4624618-2e29-4969-88d9-335bacde86a9_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalties owed to third parties</link:label>
    <link:label id="lab_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_label_en-US" xlink:label="lab_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Royalties</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedRoyaltiesCurrentAndNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent" xlink:to="lab_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_fea43a05-d467-433c-acf6-ee99832338ea_terseLabel_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Classification [Domain]</link:label>
    <link:label id="lab_us-gaap_ClassificationOfVariableInterestEntityDomain_label_en-US" xlink:label="lab_us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Classification [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:to="lab_us-gaap_ClassificationOfVariableInterestEntityDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_6172536d-3b75-4606-a7de-7aa816f31c6f_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Benchmark [Axis]</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskByBenchmarkAxis_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Benchmark [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:to="lab_us-gaap_ConcentrationRiskByBenchmarkAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_3e3f4e0b-d1c1-471c-ae16-51f337b50d81_terseLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign currency translation adjustment</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Foreign Currency Translation Adjustment</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Foreign Currency Translation Adjustment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VariableRateComponentAxis_ef6fe036-ce91-46a2-9121-a123d39e3431_terseLabel_en-US" xlink:label="lab_lgnd_VariableRateComponentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate Component [Axis]</link:label>
    <link:label id="lab_lgnd_VariableRateComponentAxis_label_en-US" xlink:label="lab_lgnd_VariableRateComponentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate Component [Axis]</link:label>
    <link:label id="lab_lgnd_VariableRateComponentAxis_documentation_en-US" xlink:label="lab_lgnd_VariableRateComponentAxis" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate Component [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentAxis" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VariableRateComponentAxis" xlink:to="lab_lgnd_VariableRateComponentAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_fa5dfa25-a5fe-4516-b5d8-7f4d9da0ade1_terseLabel_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Potentially dilutive shares excluded from calculation due to anti-dilutive effect (shares)</link:label>
    <link:label id="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_label_en-US" xlink:label="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:to="lab_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_e3f1d387-f0bd-4dad-bcbf-f1bfff1c038a_terseLabel_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Condensed Balance Sheet:</link:label>
    <link:label id="lab_us-gaap_StatementOfFinancialPositionAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Financial Position [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract" xlink:to="lab_us-gaap_StatementOfFinancialPositionAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationsAbstract_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combinations [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsAbstract" xlink:to="lab_us-gaap_BusinessCombinationsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PalvellaTherapeuticsIncMember_fcc102ea-0898-4e9f-a2a9-240fdf8c289a_terseLabel_en-US" xlink:label="lab_lgnd_PalvellaTherapeuticsIncMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Palvella</link:label>
    <link:label id="lab_lgnd_PalvellaTherapeuticsIncMember_label_en-US" xlink:label="lab_lgnd_PalvellaTherapeuticsIncMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Palvella Therapeutics, Inc. [Member]</link:label>
    <link:label id="lab_lgnd_PalvellaTherapeuticsIncMember_documentation_en-US" xlink:label="lab_lgnd_PalvellaTherapeuticsIncMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Palvella Therapeutics, Inc.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PalvellaTherapeuticsIncMember" xlink:to="lab_lgnd_PalvellaTherapeuticsIncMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_bfc86fca-72ef-484b-ad4a-7afd8aa98c9d_terseLabel_en-US" xlink:label="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Initial Application Period Cumulative Effect Transition [Axis]</link:label>
    <link:label id="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_label_en-US" xlink:label="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Initial Application Period Cumulative Effect Transition [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:to="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfDebtTableTextBlock_54f88391-0e6e-49b0-9c23-094c6e723adf_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Equity and Liability Components of the Convertible Senior Notes</link:label>
    <link:label id="lab_us-gaap_ScheduleOfDebtTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDebtTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Debt [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDebtTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDebtTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfDebtTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_5a1928ec-2ee9-4984-a1e4-a6f718a985be_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of share consideration</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_bc7cf932-156f-4640-a524-5c05f3c9177a_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total share consideration</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition, Equity Interest Issued or Issuable, Value Assigned</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_9ef46ace-8c56-4c32-9fce-45fb52a22b98_terseLabel_en-US" xlink:label="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Valuation allowance, change in amount</link:label>
    <link:label id="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_label_en-US" xlink:label="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:to="lab_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityDomain_572d2c72-2db2-40f5-a493-e30941e92347_terseLabel_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity [Domain]</link:label>
    <link:label id="lab_dei_EntityDomain_label_en-US" xlink:label="lab_dei_EntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityDomain" xlink:to="lab_dei_EntityDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_6833c748-76c7-42d2-8416-efb296847354_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Computation of Basic and Diluted Net Income (Loss) per Share</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_29d6c942-9d5f-40bb-b6f9-6c8434cc656b_terseLabel_en-US" xlink:label="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Business Acquisitions</link:label>
    <link:label id="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_label_en-US" xlink:label="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Business Acquisitions by Acquisition, Consideration Transferred [Table Text Block]</link:label>
    <link:label id="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_documentation_en-US" xlink:label="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Business Acquisitions by Acquisition, Consideration Transferred [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:to="lab_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_685689fb-4cc8-4720-84dd-d8c71eb7df06_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentByTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_4f0dab16-b07b-434c-83e3-c6fd687a13e8_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Stockholders' Equity [Roll Forward]</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Stockholders' Equity [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:to="lab_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_4b6431a5-159c-4063-80fa-0eda06a79a26_periodStartLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at beginning of period</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_58f47fa8-d185-40dd-9e9d-8c45faa8e369_periodEndLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at end of period</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:to="lab_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_d290d83c-f07e-43b0-bcd2-9bb0089a5262_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Stock Option Plan Activity</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Stock Options, Activity [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_b0ad98ac-4b3f-41d6-b709-c80dfc017658_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and Equipment</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubsequentEventTypeAxis_a326ea30-fc0e-406c-b230-237527674719_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
    <link:label id="lab_us-gaap_SubsequentEventTypeAxis_label_en-US" xlink:label="lab_us-gaap_SubsequentEventTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventTypeAxis" xlink:to="lab_us-gaap_SubsequentEventTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OfficeWinnershUnitedKingdomMember_afeed5e9-b075-4f45-b681-a171cc829eb7_terseLabel_en-US" xlink:label="lab_lgnd_OfficeWinnershUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Winnersh, United Kingdom</link:label>
    <link:label id="lab_lgnd_OfficeWinnershUnitedKingdomMember_label_en-US" xlink:label="lab_lgnd_OfficeWinnershUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Winnersh, United Kingdom [Member]</link:label>
    <link:label id="lab_lgnd_OfficeWinnershUnitedKingdomMember_documentation_en-US" xlink:label="lab_lgnd_OfficeWinnershUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Winnersh, United Kingdom</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeWinnershUnitedKingdomMember" xlink:href="lgnd-20181231.xsd#lgnd_OfficeWinnershUnitedKingdomMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OfficeWinnershUnitedKingdomMember" xlink:to="lab_lgnd_OfficeWinnershUnitedKingdomMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_a5500880-c573-41fb-9fcb-04e27bebdec2_terseLabel_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Recently Adopted and Accounting Standards Not Yet Adopted</link:label>
    <link:label id="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">New Accounting Pronouncements, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:to="lab_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_1080e387-a7d6-475e-a472-e80c0e25e9c1_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State</link:label>
    <link:label id="lab_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred State and Local Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:to="lab_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_8fa6ee6c-d24e-4f25-90a4-9374930b4053_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research credit carryforwards</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Tax Credit Carryforwards</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:to="lab_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SalesRevenueNetMember_e72de974-ad29-4188-8fa5-5a497661c0bf_terseLabel_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue</link:label>
    <link:label id="lab_us-gaap_SalesRevenueNetMember_label_en-US" xlink:label="lab_us-gaap_SalesRevenueNetMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sales Revenue, Net [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SalesRevenueNetMember" xlink:to="lab_us-gaap_SalesRevenueNetMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_0ac6618d-fa98-4712-9465-215b343d388e_terseLabel_en-US" xlink:label="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax expense (benefit) from the Tax Act</link:label>
    <link:label id="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Cuts and Jobs Act of 2017, Income Tax Expense (Benefit)</link:label>
    <link:label id="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_documentation_en-US" xlink:label="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Cuts and Jobs Act of 2017, Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:href="lgnd-20181231.xsd#lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:to="lab_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VestingDomain_fe3a1503-df0e-4670-bdfe-42d842150ee2_terseLabel_en-US" xlink:label="lab_us-gaap_VestingDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting [Domain]</link:label>
    <link:label id="lab_us-gaap_VestingDomain_label_en-US" xlink:label="lab_us-gaap_VestingDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VestingDomain" xlink:to="lab_us-gaap_VestingDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_505f1ed8-23fc-41ec-bb2e-2ca013fd369d_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Taxes paid related to net share settlement of equity awards</link:label>
    <link:label id="lab_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_label_en-US" xlink:label="lab_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments Related to Tax Withholding for Share-based Compensation</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:to="lab_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_b3b09476-e066-441c-a0ab-1ee91d3f5c2c_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State, net of federal benefit</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:to="lab_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortTermInvestmentsMember_cd682c39-71f5-4744-b5fd-5cd70fc18a8c_verboseLabel_en-US" xlink:label="lab_us-gaap_ShortTermInvestmentsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term investments</link:label>
    <link:label id="lab_us-gaap_ShortTermInvestmentsMember_4f79a94f-9680-42c6-ba01-95817fd74b5f_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermInvestmentsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term investments</link:label>
    <link:label id="lab_us-gaap_ShortTermInvestmentsMember_label_en-US" xlink:label="lab_us-gaap_ShortTermInvestmentsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Investments [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermInvestmentsMember" xlink:to="lab_us-gaap_ShortTermInvestmentsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_e18c1fff-900b-4bdc-a6da-a6e63c4e612a_terseLabel_en-US" xlink:label="lab_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership interest (as a percent)</link:label>
    <link:label id="lab_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_label_en-US" xlink:label="lab_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Limited Liability Company or Limited Partnership, Members or Limited Partners, Ownership Interest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" xlink:to="lab_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent_49cf78ac-21cd-4f5c-afc8-2177082630d6_terseLabel_en-US" xlink:label="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount of loan to be repaid in cash upon consummation of first capital financing transaction</link:label>
    <link:label id="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent_label_en-US" xlink:label="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Note Receivable, Cash Due Upon Triggering Event</link:label>
    <link:label id="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent_documentation_en-US" xlink:label="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Note Receivable, Cash Due Upon Triggering Event</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableCashDueUponTriggeringEvent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:to="lab_lgnd_NoteReceivableCashDueUponTriggeringEvent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_aa09b27a-e06c-466b-8b28-7189b779ba62_terseLabel_en-US" xlink:label="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">AOCI Including Portion Attributable to Noncontrolling Interest</link:label>
    <link:label id="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_label_en-US" xlink:label="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">AOCI Including Portion Attributable to Noncontrolling Interest [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:to="lab_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LongtermDebtTypeDomain_8cc6b497-20f6-4946-90d8-ca010b76a7a6_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_LongtermDebtTypeDomain_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeDomain" xlink:to="lab_us-gaap_LongtermDebtTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_ba767403-3200-4ef3-8541-feee32c400cd_terseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additions for tax positions of prior years</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:to="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentTextBlock_e43288a6-1ac3-4c8e-a839-affa2d45d9e4_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Property and Equipment</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentTextBlock_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_168a7d19-b9b5-4e78-986b-5e0ad494dd15_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net operating loss carryforwards</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Operating Loss Carryforwards</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:to="lab_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VariableRateComponentDomain_023a2d8b-7c21-46c2-9fea-cb1845a33c07_terseLabel_en-US" xlink:label="lab_lgnd_VariableRateComponentDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate Component [Domain]</link:label>
    <link:label id="lab_lgnd_VariableRateComponentDomain_label_en-US" xlink:label="lab_lgnd_VariableRateComponentDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Rate Component [Domain]</link:label>
    <link:label id="lab_lgnd_VariableRateComponentDomain_documentation_en-US" xlink:label="lab_lgnd_VariableRateComponentDomain" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">[Domain] for Variable Rate Component [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentDomain" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VariableRateComponentDomain" xlink:to="lab_lgnd_VariableRateComponentDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_1089b911-f175-447e-9b89-7641d8f83667_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]</link:label>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Amount [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:to="lab_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_5f56332f-56d3-47c5-87dd-94e2af14114d_terseLabel_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value adjustments to contingent liabilities</link:label>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_0a5e666b-fb2b-47a1-afab-bd9296d48d69_verboseLabel_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Adjustment</link:label>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_label_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities</link:label>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_documentation_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:to="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_38e41334-a4d8-4cab-acc2-c4488556305e_verboseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross payments to acquire business</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_5a773017-4e8b-4245-a6ac-30ecf9361f9d_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash consideration</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesGross_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Businesses, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesGross" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesGross" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_b9c7433c-d49d-4a32-a40f-33acc3d0c4db_terseLabel_en-US" xlink:label="lab_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Difference between Revenue Guidance in Effect before and after Topic 606</link:label>
    <link:label id="lab_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_label_en-US" xlink:label="lab_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Difference between Revenue Guidance in Effect before and after Topic 606 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:to="lab_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeNineMember_1fc9be27-420a-4715-a576-6c8361db248e_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeNineMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$74.42 - $74.42</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeNineMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeNineMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Nine [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeNineMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeNineMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Nine [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeNineMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeNineMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeNineMember" xlink:to="lab_lgnd_ExercisePriceRangeNineMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_287c336a-f7b2-4eb5-9205-953b6b7a0f19_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock issued under amended ESSP (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_c655a8be-0424-4917-a978-0b5773ce1ae1_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current liabilities assumed</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_fd3f9352-fc40-48d1-b3f6-b9ff3095ab80_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Viking</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Primary Beneficiary [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:to="lab_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember" xlink:type="arc" order="1"/>
    <link:label id="lab_stpr_KS_4cde1833-79b8-483a-94f4-845b31ce6631_verboseLabel_en-US" xlink:label="lab_stpr_KS" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Kansas</link:label>
    <link:label id="lab_stpr_KS_label_en-US" xlink:label="lab_stpr_KS" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">KANSAS</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_KS" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_KS"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_stpr_KS" xlink:to="lab_stpr_KS" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_d68d3071-fac3-4981-87b4-ef1362228db1_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of premium (discount) on investments, net</link:label>
    <link:label id="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_label_en-US" xlink:label="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accretion (Amortization) of Discounts and Premiums, Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:to="lab_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_7892616a-8205-46dd-ae38-16a135d8cfa0_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted-Average Grant Date Fair Value [Roll Forward]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_223cb89f-b0ea-45ad-a527-d69cbb75aa4c_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase the number of shares under the 2002 Stock Incentive Plan (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel3Member_8ff3e9ca-4aeb-44a6-b7e5-defcd6d51fcf_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Significant Unobservable Inputs (Level 3)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel3Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel3Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Inputs, Level 3 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel3Member" xlink:to="lab_us-gaap_FairValueInputsLevel3Member" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_501896ee-dcfd-460e-93a1-148bcb2afe08_terseLabel_en-US" xlink:label="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in notes receivable fair value</link:label>
    <link:label id="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_label_en-US" xlink:label="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Notes Receivable, Fair Value, Period Increase (Decrease)</link:label>
    <link:label id="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_documentation_en-US" xlink:label="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Notes Receivable, Fair Value, Period Increase (Decrease)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:to="lab_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_f8ea3fff-acf7-4178-a748-2022ac8ad63c_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized net gain on available-for-sale securities, net of tax</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, after Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_47652084-447d-48be-9451-8788548a2f85_terseLabel_en-US" xlink:label="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fixed assets and intangibles</link:label>
    <link:label id="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_label_en-US" xlink:label="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Property, Plant and Equipment and Intangible Assets</link:label>
    <link:label id="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_documentation_en-US" xlink:label="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Property, Plant and Equipment and Intangible Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:to="lab_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_dd03c978-a6c8-42a2-b465-b1a65cb1db46_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and equipment, useful life</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Useful Life</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentUsefulLife" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NotesReceivableMember_b5019c55-4218-4ca7-8b4f-a15d08288a80_terseLabel_en-US" xlink:label="lab_us-gaap_NotesReceivableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes receivable Viking</link:label>
    <link:label id="lab_us-gaap_NotesReceivableMember_label_en-US" xlink:label="lab_us-gaap_NotesReceivableMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes Receivable [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesReceivableMember" xlink:to="lab_us-gaap_NotesReceivableMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_aa06c76c-4a37-4e82-8039-068fb7664041_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, Total</link:label>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:to="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InventoryWriteDown_935fc79c-604a-4096-ae0d-199abbd65e21_terseLabel_en-US" xlink:label="lab_us-gaap_InventoryWriteDown" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Write-downs related to obsolete inventory</link:label>
    <link:label id="lab_us-gaap_InventoryWriteDown_label_en-US" xlink:label="lab_us-gaap_InventoryWriteDown" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory Write-down</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWriteDown"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryWriteDown" xlink:to="lab_us-gaap_InventoryWriteDown" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommercialPaperMember_33f22329-93fa-40ff-84f0-1dac15fbbeb1_terseLabel_en-US" xlink:label="lab_us-gaap_CommercialPaperMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial paper</link:label>
    <link:label id="lab_us-gaap_CommercialPaperMember_label_en-US" xlink:label="lab_us-gaap_CommercialPaperMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial Paper [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommercialPaperMember" xlink:to="lab_us-gaap_CommercialPaperMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_103c3e11-a1c6-4bbc-8b7d-73b10f366b2b_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Quarterly Financial Information</link:label>
    <link:label id="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Quarterly Financial Information [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_58f3c14f-92a2-484a-8d96-7870d71977e3_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible loan facility extended</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Financial or Other Support, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount" xlink:to="lab_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_0dde3631-c18b-4aef-a52c-c380e21298e9_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByLiabilityClassAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability Class [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis" xlink:to="lab_us-gaap_FairValueByLiabilityClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltyAgreementExpirationPeriod_7388fcb9-223a-42f0-9767-61792066f3f2_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltyAgreementExpirationPeriod" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expiration period of royalty agreement</link:label>
    <link:label id="lab_lgnd_RoyaltyAgreementExpirationPeriod_label_en-US" xlink:label="lab_lgnd_RoyaltyAgreementExpirationPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty Agreement, Expiration Period</link:label>
    <link:label id="lab_lgnd_RoyaltyAgreementExpirationPeriod_documentation_en-US" xlink:label="lab_lgnd_RoyaltyAgreementExpirationPeriod" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty Agreement, Expiration Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyAgreementExpirationPeriod" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyAgreementExpirationPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltyAgreementExpirationPeriod" xlink:to="lab_lgnd_RoyaltyAgreementExpirationPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureAbstract_label_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Disclosure [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract" xlink:to="lab_us-gaap_IncomeTaxDisclosureAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_WarrantsSettled_9f5d234d-784b-425f-8954-af4f576ddfed_terseLabel_en-US" xlink:label="lab_lgnd_WarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants settled (in shares)</link:label>
    <link:label id="lab_lgnd_WarrantsSettled_label_en-US" xlink:label="lab_lgnd_WarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants Settled</link:label>
    <link:label id="lab_lgnd_WarrantsSettled_documentation_en-US" xlink:label="lab_lgnd_WarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants Settled</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsSettled" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsSettled"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_WarrantsSettled" xlink:to="lab_lgnd_WarrantsSettled" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c280fa22-751e-4d30-b8f8-56dc2e4ba2f6_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Impairment of intangible assets with finite lives</link:label>
    <link:label id="lab_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_label_en-US" xlink:label="lab_us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Impairment of Intangible Assets, Finite-lived</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:to="lab_us-gaap_ImpairmentOfIntangibleAssetsFinitelived" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_6458b9b4-958e-46b9-993a-394a5ffc3d26_totalLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_ComprehensiveIncomeNetOfTax_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive Income (Loss), Net of Tax, Attributable to Parent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax" xlink:to="lab_us-gaap_ComprehensiveIncomeNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_02cc4b2d-31f9-457b-9a63-63c5a842b5f5_terseLabel_en-US" xlink:label="lab_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Calculated under Revenue Guidance in Effect before Topic 606</link:label>
    <link:label id="lab_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_label_en-US" xlink:label="lab_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Calculated under Revenue Guidance in Effect before Topic 606 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:to="lab_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_df8acff1-f931-49b3-a4b4-3621e44ac806_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Recognized Identified Assets Acquired and Liabilities Assumed</link:label>
    <link:label id="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityRegistrantName_ba175f13-919a-4e97-a1a3-a1f7e9a90c67_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:label id="lab_dei_EntityRegistrantName_label_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityRegistrantName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName" xlink:to="lab_dei_EntityRegistrantName" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_33e14820-21dc-42a3-ba57-7e94eaa2739c_terseLabel_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Supplemental schedule of non-cash investing and financing activities</link:label>
    <link:label id="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_label_en-US" xlink:label="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:to="lab_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_122646a6-4eec-45ac-839b-625fcd1bfb97_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock repurchase program, authorized amount</link:label>
    <link:label id="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1_label_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchase Program, Authorized Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:to="lab_us-gaap_StockRepurchaseProgramAuthorizedAmount1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_6a18febb-1eec-4db9-8f9f-e921e2673ed4_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Issuance of common stock under employee stock compensation plans, net (shares)</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Shares, Employee Stock Purchase Plans</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:to="lab_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_636970d6-8dff-4d99-8ff6-a2a2c7cae6c9_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated other comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated Other Comprehensive Income (Loss), Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_cf66a347-5d65-4602-9a12-73ebd96f11e2_terseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additions based on tax positions related to the current year</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:to="lab_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RoyaltyMember_d985713e-e511-4a27-af2e-28f9a050b0a2_terseLabel_en-US" xlink:label="lab_us-gaap_RoyaltyMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalties</link:label>
    <link:label id="lab_us-gaap_RoyaltyMember_label_en-US" xlink:label="lab_us-gaap_RoyaltyMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RoyaltyMember" xlink:to="lab_us-gaap_RoyaltyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_91cebfc7-08d7-43db-b9fc-a714684309ff_terseLabel_en-US" xlink:label="lab_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Major Customers</link:label>
    <link:label id="lab_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_label_en-US" xlink:label="lab_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedules of Concentration of Risk, by Risk Factor [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:to="lab_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_0990ab58-1f96-4000-9555-53b8d60199bb_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares [Rollforward]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_75169b85-04ea-4e4e-8e86-89dfd56533b2_terseLabel_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additions</link:label>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_label_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition Contingent Consideration Potential Cash Payment Additions</link:label>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_documentation_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition Contingent Consideration Potential Cash Payment Additions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:to="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201601Member_4ac7863d-c2b0-42ed-84f9-1c2175950c26_terseLabel_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201601Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-01</link:label>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201601Member_label_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201601Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-01 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingStandardsUpdate201601Member" xlink:to="lab_us-gaap_AccountingStandardsUpdate201601Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_8c6f072b-5541-4d7d-83bb-55715e1b5a34_terseLabel_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of the conversion option derivative liability</link:label>
    <link:label id="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_label_en-US" xlink:label="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Embedded Derivative, Fair Value of Embedded Derivative Liability</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:to="lab_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_65ebf59d-e17a-4e54-a8ad-9c9f582b01ed_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock repurchase program, remaining authorized repurchase amount</link:label>
    <link:label id="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_label_en-US" xlink:label="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchase Program, Remaining Authorized Repurchase Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:to="lab_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_55a6fabc-eede-4fa7-9fac-3c57f27b81f6_terseLabel_en-US" xlink:label="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Cambridge, United Kingdom</link:label>
    <link:label id="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_label_en-US" xlink:label="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Cambridge, United Kingdom [Member]</link:label>
    <link:label id="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_documentation_en-US" xlink:label="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Cambridge, United Kingdom</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityCambridgeUnitedKingdomMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:to="lab_lgnd_ResearchFacilityCambridgeUnitedKingdomMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncomeTaxReconciliationContingentValueRights_8b8df9a6-cdb7-4838-b71a-2ac13eb8d152_terseLabel_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent liabilities</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationContingentValueRights_label_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Contingent Value Rights</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationContingentValueRights_documentation_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Contingent Value Rights</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationContingentValueRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:to="lab_lgnd_IncomeTaxReconciliationContingentValueRights" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquitySecuritiesMember_19e7efa8-3372-476b-8406-b63c69014e80_terseLabel_en-US" xlink:label="lab_us-gaap_EquitySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate equity securities</link:label>
    <link:label id="lab_us-gaap_EquitySecuritiesMember_label_en-US" xlink:label="lab_us-gaap_EquitySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquitySecuritiesMember" xlink:to="lab_us-gaap_EquitySecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PurchaseofCommonStockMember_cd56f877-6954-4547-bc4b-5a50d925531b_terseLabel_en-US" xlink:label="lab_lgnd_PurchaseofCommonStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of Common Stock</link:label>
    <link:label id="lab_lgnd_PurchaseofCommonStockMember_label_en-US" xlink:label="lab_lgnd_PurchaseofCommonStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of Common Stock [Member]</link:label>
    <link:label id="lab_lgnd_PurchaseofCommonStockMember_documentation_en-US" xlink:label="lab_lgnd_PurchaseofCommonStockMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of Common Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseofCommonStockMember" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseofCommonStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PurchaseofCommonStockMember" xlink:to="lab_lgnd_PurchaseofCommonStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_6f06a12b-4810-47d6-b766-a1392451536f_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Definite lived intangible assets</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsGross_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsGross" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_deb43f24-781d-45f0-96f6-20d69d981600_terseLabel_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in if-converted value in excess of principal</link:label>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_label_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Increase (Decrease) If-Converted Value in Excess of Principal</link:label>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_documentation_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Increase (Decrease) If-Converted Value in Excess of Principal</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:to="lab_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_e1f11582-4d79-4268-90e1-97e7f0cd7f22_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (loss) from operations</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_6e82d52f-be6b-425d-96f9-48def0a81e7c_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (loss) from continuing operations</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_72d506e2-d9c9-4b13-bc74-e61f62caa896_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments [Domain]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeCategorizationMember_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investments [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember" xlink:to="lab_us-gaap_InvestmentTypeCategorizationMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StateAndLocalJurisdictionMember_537533ce-65c1-455c-b880-67f021ca4eca_terseLabel_en-US" xlink:label="lab_us-gaap_StateAndLocalJurisdictionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State and Local Jurisdiction</link:label>
    <link:label id="lab_us-gaap_StateAndLocalJurisdictionMember_label_en-US" xlink:label="lab_us-gaap_StateAndLocalJurisdictionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State and Local Jurisdiction [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StateAndLocalJurisdictionMember" xlink:to="lab_us-gaap_StateAndLocalJurisdictionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_9f20e308-3a9c-4c2a-9885-b6c4782c7653_negatedLabel_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to CVR holders and other contingency payments</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_label_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Contingent Value Right Holders and Other Contingency Payments, Investing Activity</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_documentation_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Contingent Value Right Holders and Other Contingency Payments, Investing Activity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:to="lab_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_e3c5b443-f698-453d-ba21-878046550c71_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercisable at end of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_d57db050-420e-415d-95c4-544622c90417_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurements, Fair Value Hierarchy [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hierarchy and NAV [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:to="lab_us-gaap_FairValueMeasurementsFairValueHierarchyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDerivativeLiabilities_708cd529-441a-414e-b904-56763a3dc43a_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDerivativeLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in derivative liabilities</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDerivativeLiabilities_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDerivativeLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Derivative Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities" xlink:to="lab_us-gaap_IncreaseDecreaseInDerivativeLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_1f016cca-a83f-48db-80d1-bffc52f83725_terseLabel_en-US" xlink:label="lab_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Price per share of shares repurchased (USD per share)</link:label>
    <link:label id="lab_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_label_en-US" xlink:label="lab_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accelerated Share Repurchases, Final Price Paid Per Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare" xlink:to="lab_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentGross_71b0d230-428a-4bf0-ba3b-3285e5624023_verboseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentGross" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and equipment , gross</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentGross_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentGross" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_7b1ddd20-6c23-4cea-af97-c1feef10d3c3_terseLabel_en-US" xlink:label="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties</link:label>
    <link:label id="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_label_en-US" xlink:label="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties [Member]</link:label>
    <link:label id="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_documentation_en-US" xlink:label="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:href="lgnd-20181231.xsd#lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:to="lab_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_32f99809-560b-4a4f-9e36-2ddcc514e39d_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property and equipment, net</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_81d40baa-2009-402f-bc23-21e8e8f8db10_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Recognition</link:label>
    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue from Contract with Customer [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:to="lab_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_SegmentGeographicalDomain_c10525d5-280e-4ea6-89ec-b7cf1013e9b5_terseLabel_en-US" xlink:label="lab_srt_SegmentGeographicalDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Segment, Geographical [Domain]</link:label>
    <link:label id="lab_srt_SegmentGeographicalDomain_label_en-US" xlink:label="lab_srt_SegmentGeographicalDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Geographical [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_SegmentGeographicalDomain" xlink:to="lab_srt_SegmentGeographicalDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RestructuringReserve_39c2c787-e5ff-4a14-8e0d-a7b4d3977c7a_negatedLabel_en-US" xlink:label="lab_us-gaap_RestructuringReserve" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restructuring and product reserves</link:label>
    <link:label id="lab_us-gaap_RestructuringReserve_label_en-US" xlink:label="lab_us-gaap_RestructuringReserve" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restructuring Reserve</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestructuringReserve" xlink:to="lab_us-gaap_RestructuringReserve" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_70e8bc9d-b696-4617-b5ff-32a086ae83fe_terseLabel_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Relationship to Entity [Domain]</link:label>
    <link:label id="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_label_en-US" xlink:label="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Relationship to Entity [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:to="lab_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment_4cad0ff8-c8d6-42af-9fd0-5a5b0dca00a9_terseLabel_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in equity method investment</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment_label_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Equity Method Investment</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment_documentation_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Equity Method Investment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinEquityMethodInvestment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:to="lab_lgnd_IncreaseDecreaseinEquityMethodInvestment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_78c8463c-5da1-4508-8ee2-955c3897a7f7_terseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of debt discount and issuance fees</link:label>
    <link:label id="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts_label_en-US" xlink:label="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of Debt Issuance Costs and Discounts</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:to="lab_us-gaap_AmortizationOfFinancingCostsAndDiscounts" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RepaymentsOfLongTermDebt_8a829b46-d6bd-4f72-846a-a50e7eb5b3b7_negatedLabel_en-US" xlink:label="lab_us-gaap_RepaymentsOfLongTermDebt" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repayments of debt</link:label>
    <link:label id="lab_us-gaap_RepaymentsOfLongTermDebt_label_en-US" xlink:label="lab_us-gaap_RepaymentsOfLongTermDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repayments of Long-term Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RepaymentsOfLongTermDebt" xlink:to="lab_us-gaap_RepaymentsOfLongTermDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_MajorCustomersAxis_9b299639-979f-4219-a6fa-9a95232ef5bd_terseLabel_en-US" xlink:label="lab_srt_MajorCustomersAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer [Axis]</link:label>
    <link:label id="lab_srt_MajorCustomersAxis_label_en-US" xlink:label="lab_srt_MajorCustomersAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MajorCustomersAxis" xlink:to="lab_srt_MajorCustomersAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ProductRoyaltyPercentage_5112842a-d073-47f9-a2b9-9dd6d3f43126_terseLabel_en-US" xlink:label="lab_lgnd_ProductRoyaltyPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product royalty (as a percent)</link:label>
    <link:label id="lab_lgnd_ProductRoyaltyPercentage_label_en-US" xlink:label="lab_lgnd_ProductRoyaltyPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product Royalty Percentage</link:label>
    <link:label id="lab_lgnd_ProductRoyaltyPercentage_documentation_en-US" xlink:label="lab_lgnd_ProductRoyaltyPercentage" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product Royalty Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ProductRoyaltyPercentage" xlink:href="lgnd-20181231.xsd#lgnd_ProductRoyaltyPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ProductRoyaltyPercentage" xlink:to="lab_lgnd_ProductRoyaltyPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_3e12ab3f-58b5-416d-98b8-c0cfc681331c_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible bond hedge and warrant transactions, net of tax</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RestrictedStockMember_a8d31650-52f9-4b7c-b6c7-887280f593e3_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Stock</link:label>
    <link:label id="lab_us-gaap_RestrictedStockMember_label_en-US" xlink:label="lab_us-gaap_RestrictedStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedStockMember" xlink:to="lab_us-gaap_RestrictedStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OtherBalanceSheetDetailsAbstract_label_en-US" xlink:label="lab_lgnd_OtherBalanceSheetDetailsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Balance Sheet Details [Abstract]</link:label>
    <link:label id="lab_lgnd_OtherBalanceSheetDetailsAbstract_documentation_en-US" xlink:label="lab_lgnd_OtherBalanceSheetDetailsAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Balance Sheet Details [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract" xlink:to="lab_lgnd_OtherBalanceSheetDetailsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_6e4f7118-efc7-4933-aa01-3323e1d03487_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Type [Domain]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Award [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_de4ca35b-3773-416c-ade4-4d81df845031_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosures [Line Items]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosures [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrealizedGainLossOnInvestments_380320c7-5f19-4427-9384-86ddaed2772e_terseLabel_en-US" xlink:label="lab_us-gaap_UnrealizedGainLossOnInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized gain on AFS investments</link:label>
    <link:label id="lab_us-gaap_UnrealizedGainLossOnInvestments_label_en-US" xlink:label="lab_us-gaap_UnrealizedGainLossOnInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrealized Gain (Loss) on Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrealizedGainLossOnInvestments" xlink:to="lab_us-gaap_UnrealizedGainLossOnInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_92521043-f529-4cd1-b1b4-243560f873b9_negatedLabel_en-US" xlink:label="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less accumulated depreciation and amortization</link:label>
    <link:label id="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_label_en-US" xlink:label="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:to="lab_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_e0b8c4d0-3346-4b1f-91a5-f76bcc18e3cb_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, by Nature [Axis]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentRiskAxis_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis" xlink:to="lab_us-gaap_DerivativeInstrumentRiskAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromNotesPayable_ef6e6a06-6b42-47fa-9f32-6150a9da07bb_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromNotesPayable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross proceeds from issuance of 2023 Convertible Senior Notes</link:label>
    <link:label id="lab_us-gaap_ProceedsFromNotesPayable_label_en-US" xlink:label="lab_us-gaap_ProceedsFromNotesPayable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Notes Payable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromNotesPayable" xlink:to="lab_us-gaap_ProceedsFromNotesPayable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_51f70ed4-84d6-4ba0-bb1c-38a4e2346b94_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Quoted Prices in Active Markets for Identical Assets (Level 1)</link:label>
    <link:label id="lab_us-gaap_FairValueInputsLevel1Member_label_en-US" xlink:label="lab_us-gaap_FairValueInputsLevel1Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Inputs, Level 1 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueInputsLevel1Member" xlink:to="lab_us-gaap_FairValueInputsLevel1Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_fd6fcac0-e878-409b-b814-847e1ccb0897_totalLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Amortized Cost</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:to="lab_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_5e5abff3-10f1-4a9b-a96d-a1d4fbd90678_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash received from options exercised</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpenseMember_93b9baac-8168-444a-a4f4-880d68e3d5d0_terseLabel_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpenseMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and administrative expenses</link:label>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpenseMember_label_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpenseMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and Administrative Expense [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GeneralAndAdministrativeExpenseMember" xlink:to="lab_us-gaap_GeneralAndAdministrativeExpenseMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PriorPeriodReclassificationAdjustmentDescription_e0939872-6534-4072-8319-ec5f703a9290_terseLabel_en-US" xlink:label="lab_us-gaap_PriorPeriodReclassificationAdjustmentDescription" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reclassifications</link:label>
    <link:label id="lab_us-gaap_PriorPeriodReclassificationAdjustmentDescription_label_en-US" xlink:label="lab_us-gaap_PriorPeriodReclassificationAdjustmentDescription" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reclassification, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PriorPeriodReclassificationAdjustmentDescription"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription" xlink:to="lab_us-gaap_PriorPeriodReclassificationAdjustmentDescription" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_2b3aa995-2894-4517-8d19-9a5ef005cc95_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Stock Option Plan Activity by Exercise Price Range</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" xlink:to="lab_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeStatementLocationAxis_a7b3a847-7ef1-4f91-8f1a-7cfb396c705d_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Axis]</link:label>
    <link:label id="lab_us-gaap_IncomeStatementLocationAxis_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationAxis" xlink:to="lab_us-gaap_IncomeStatementLocationAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LiabilityForContingentValueRights_3b2f6348-94fc-4311-97a9-3770ddb99273_verboseLabel_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term contingent liabilities</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRights_label_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability for Contingent Value Rights</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRights_documentation_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability for contingent value rights.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRights" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LiabilityForContingentValueRights" xlink:to="lab_lgnd_LiabilityForContingentValueRights" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CashPaidtoAcquireBusiness_02c4a9c8-00f7-4403-b116-7f7ba9f2e738_terseLabel_en-US" xlink:label="lab_lgnd_CashPaidtoAcquireBusiness" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash paid to Crystal shareholders</link:label>
    <link:label id="lab_lgnd_CashPaidtoAcquireBusiness_label_en-US" xlink:label="lab_lgnd_CashPaidtoAcquireBusiness" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Paid to Acquire Business</link:label>
    <link:label id="lab_lgnd_CashPaidtoAcquireBusiness_documentation_en-US" xlink:label="lab_lgnd_CashPaidtoAcquireBusiness" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Paid to Acquire Business</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPaidtoAcquireBusiness" xlink:href="lgnd-20181231.xsd#lgnd_CashPaidtoAcquireBusiness"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CashPaidtoAcquireBusiness" xlink:to="lab_lgnd_CashPaidtoAcquireBusiness" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesAbstract_e3b03536-e981-4e64-a778-2d8c1d46a0c8_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred tax liabilities:</link:label>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesAbstract_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Gross [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract" xlink:to="lab_us-gaap_DeferredTaxLiabilitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_5404ff95-4f0c-4f1c-8405-12743f790024_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period [Axis]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_b3717784-894a-47a2-ac83-f7bd6d767d7f_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash provided by operating activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_8ad4dcbc-70b2-42a7-b62d-12ddee3f1979_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash provided by operating activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_aabd3c3a-46be-45c4-9d31-b868a1770505_periodStartLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at beginning of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_93150d0b-61a1-4f69-8545-cd226fd57bea_periodEndLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at end of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_c28c9d46-17ef-4d01-b46a-7731aab7e733_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other current assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Prepaid Expense and Other Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:to="lab_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_11a71cea-c46f-4fa3-896e-bdc7c8bd462d_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss on equity investment in Viking</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromEquityMethodInvestments_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Equity Method Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromEquityMethodInvestments" xlink:to="lab_us-gaap_IncomeLossFromEquityMethodInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentTypeAxis_4d39459d-e1bb-442b-9774-0e6c68fbf782_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:label id="lab_us-gaap_InvestmentTypeAxis_label_en-US" xlink:label="lab_us-gaap_InvestmentTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentTypeAxis" xlink:to="lab_us-gaap_InvestmentTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2019Member_f7180287-802d-4dd2-bffb-80732c444355_terseLabel_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2019Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2019 Convertible Senior Notes</link:label>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2019Member_label_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2019Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Senior Notes, 2019 [Member]</link:label>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2019Member_documentation_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2019Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Senior Notes, 2019 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ConvertibleSeniorNotes2019Member" xlink:to="lab_lgnd_ConvertibleSeniorNotes2019Member" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_EquityMethodInvesteeNameDomain_968cc745-0c10-414c-a895-87b03b85a670_terseLabel_en-US" xlink:label="lab_srt_EquityMethodInvesteeNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment, Name [Domain]</link:label>
    <link:label id="lab_srt_EquityMethodInvesteeNameDomain_label_en-US" xlink:label="lab_srt_EquityMethodInvesteeNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment, Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_EquityMethodInvesteeNameDomain" xlink:to="lab_srt_EquityMethodInvesteeNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquityMethodInvesteeMember_5da5166d-6380-4955-a1d4-8d8452ee41a9_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investee</link:label>
    <link:label id="lab_us-gaap_EquityMethodInvesteeMember_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvesteeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investee [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvesteeMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvesteeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvesteeMember" xlink:to="lab_us-gaap_EquityMethodInvesteeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_28991fc1-d65c-4e0f-8b42-fa0ec3d7f3c3_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible debt conversion ratio</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Conversion Ratio</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionRatio1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_9577ffc4-4f04-46cb-99c5-ea3467eb0d95_terseLabel_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign Currency Translation</link:label>
    <link:label id="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign Currency Transactions and Translations Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:to="lab_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntityLineItems_1e47b94c-0a93-47c5-a9ea-b3a4edfc2001_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity [Line Items]</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityLineItems_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityLineItems" xlink:to="lab_us-gaap_VariableInterestEntityLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_204b5920-1fec-435f-ba9f-e5cc6d9192c3_terseLabel_en-US" xlink:label="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold business days for repayment of principal</link:label>
    <link:label id="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_label_en-US" xlink:label="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Business Days for Repayment of Principal</link:label>
    <link:label id="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_documentation_en-US" xlink:label="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Business Days for Repayment of Principal</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdBusinessDaysforRepaymentofPrincipal"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:to="lab_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingIncomeLoss_e4900335-c834-4693-b2c6-191f21489e0b_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income from operations</link:label>
    <link:label id="lab_us-gaap_OperatingIncomeLoss_label_en-US" xlink:label="lab_us-gaap_OperatingIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Income (Loss)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingIncomeLoss" xlink:to="lab_us-gaap_OperatingIncomeLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardAxis_186156a8-86d9-43f6-827e-373f89a90ed7_terseLabel_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credit Carryforward [Axis]</link:label>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardAxis_label_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credit Carryforward [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis" xlink:to="lab_us-gaap_TaxCreditCarryforwardAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_9b59847f-7972-4986-92e5-22f9dfe21bb3_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrant derivative</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_788d0917-698f-41e6-a4cb-8b7f7e06cdac_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Value of warrants issued</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrant Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock_2562b238-b44a-4e8d-8c01-962b2c917d0b_verboseLabel_en-US" xlink:label="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Equivalents &amp; Short Term Investments</link:label>
    <link:label id="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock_label_en-US" xlink:label="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, Cash Equivalents, and Short-term Investments [Policy Text Block]</link:label>
    <link:label id="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock_documentation_en-US" xlink:label="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, Cash Equivalents, and Short-term Investments [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:to="lab_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3a3926e7-403c-49eb-82cc-fb39344ae226_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities assumed</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_ff4748a9-cb41-48e7-846e-63cbd8f94bb0_verboseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assumed liabilities</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_764a0f0d-d392-45ed-bd93-023b1bc1aba7_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reclassification of equity component of currently redeemable convertible notes</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_8366358f-7e04-45d5-9276-00ac1dd4bf00_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt issuance costs related to the equity component of convertible debt</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CorporateShareRepurchaseAbstract_be2ad07d-9c60-4e52-a59e-781145b92271_terseLabel_en-US" xlink:label="lab_lgnd_CorporateShareRepurchaseAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Share Repurchase</link:label>
    <link:label id="lab_lgnd_CorporateShareRepurchaseAbstract_label_en-US" xlink:label="lab_lgnd_CorporateShareRepurchaseAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Share Repurchase [Abstract]</link:label>
    <link:label id="lab_lgnd_CorporateShareRepurchaseAbstract_documentation_en-US" xlink:label="lab_lgnd_CorporateShareRepurchaseAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Share Repurchase [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateShareRepurchaseAbstract" xlink:href="lgnd-20181231.xsd#lgnd_CorporateShareRepurchaseAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract" xlink:to="lab_lgnd_CorporateShareRepurchaseAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_48085d41-034c-407e-9a7a-2508d8b678f8_periodStartLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding at beginning of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_fcc22a40-ac85-4457-8f4b-b540f2235239_periodEndLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding at end of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeSixMember_857a86b6-b4b7-4553-868d-e61a6706d7cf_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSixMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$32.00 - $56.26</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeSixMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSixMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Six [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeSixMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeSixMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Six [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSixMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSixMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeSixMember" xlink:to="lab_lgnd_ExercisePriceRangeSixMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_7e7215c8-cd04-4544-a0bf-f17fd6079865_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expected volatility (as a percent)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_507131cc-d797-4a5d-a96f-8c41d15659ff_totalLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, 3-4 years, net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in Three and Four Years, Net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in Three and Four Years, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_bc9cf00b-0593-49f8-b4dc-c8934af9533c_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Finite-Lived Intangible Assets [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:to="lab_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationOtherAdjustments_2cb94711-0f36-49ef-8ee9-ec72988d4600_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationOtherAdjustments_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Other Adjustments, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:to="lab_us-gaap_IncomeTaxReconciliationOtherAdjustments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RoyaltyAgreementsMember_b957a35e-b069-4392-8ba1-94884a3b1b72_terseLabel_en-US" xlink:label="lab_us-gaap_RoyaltyAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty Agreements</link:label>
    <link:label id="lab_us-gaap_RoyaltyAgreementsMember_label_en-US" xlink:label="lab_us-gaap_RoyaltyAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyAgreementsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RoyaltyAgreementsMember" xlink:to="lab_us-gaap_RoyaltyAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_09de60c1-8966-4417-9b74-d95168d6146d_terseLabel_en-US" xlink:label="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional royalties receivable under sales-based milestones</link:label>
    <link:label id="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_label_en-US" xlink:label="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Royalties Receivable Under Sales-based Milestones</link:label>
    <link:label id="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_documentation_en-US" xlink:label="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Royalties Receivable Under Sales-based Milestones</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:to="lab_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_8e7426a1-d280-4810-9d8e-8197581c5b10_terseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indefinite-lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indefinite-lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Liabilities_d25baaf9-5b44-4753-8483-4b431c74eaa2_totalLabel_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total liabilities</link:label>
    <link:label id="lab_us-gaap_Liabilities_label_en-US" xlink:label="lab_us-gaap_Liabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Liabilities" xlink:to="lab_us-gaap_Liabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareBasic_ddc419ed-92ee-4616-96f0-b2d9688080e1_totalLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss) - Basic (USD per share)</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasic_b6875479-9e75-48d2-8ba4-7cee9514c04f_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss) - Basic (USD per share)</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasic_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasic" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Basic</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasic" xlink:to="lab_us-gaap_EarningsPerShareBasic" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLossCarryforwardsTable_f0f21e4f-7f98-4813-afd5-83967873de3a_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwardsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Loss Carryforwards [Table]</link:label>
    <link:label id="lab_us-gaap_OperatingLossCarryforwardsTable_label_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwardsTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Loss Carryforwards [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable" xlink:to="lab_us-gaap_OperatingLossCarryforwardsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_label_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Quarterly Financial Information Disclosure [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:to="lab_us-gaap_QuarterlyFinancialInformationDisclosureAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_4c34f3a4-eb9d-45f3-bd70-a6c8e888e37d_verboseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesRestrictedStock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted stock (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesRestrictedStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares, Restricted Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesRestrictedStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesRestrictedStock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_9ae9e773-f38f-40c3-8f35-9a14034a2e07_terseLabel_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance Sheet Account Details</link:label>
    <link:label id="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_label_en-US" xlink:label="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Supplemental Balance Sheet Disclosures [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:to="lab_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PartnerAMember_dc8ab28b-d44d-4746-b8bb-749981920347_terseLabel_en-US" xlink:label="lab_lgnd_PartnerAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner A</link:label>
    <link:label id="lab_lgnd_PartnerAMember_label_en-US" xlink:label="lab_lgnd_PartnerAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner A [Member]</link:label>
    <link:label id="lab_lgnd_PartnerAMember_documentation_en-US" xlink:label="lab_lgnd_PartnerAMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner A [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerAMember" xlink:href="lgnd-20181231.xsd#lgnd_PartnerAMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PartnerAMember" xlink:to="lab_lgnd_PartnerAMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OfficeEmeryvilleCAMember_130e79f0-aac8-4681-8ce4-600c5e7be281_terseLabel_en-US" xlink:label="lab_lgnd_OfficeEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Emeryville, CA</link:label>
    <link:label id="lab_lgnd_OfficeEmeryvilleCAMember_label_en-US" xlink:label="lab_lgnd_OfficeEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Emeryville, CA [Member]</link:label>
    <link:label id="lab_lgnd_OfficeEmeryvilleCAMember_documentation_en-US" xlink:label="lab_lgnd_OfficeEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office - Emeryville, CA [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeEmeryvilleCAMember" xlink:href="lgnd-20181231.xsd#lgnd_OfficeEmeryvilleCAMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OfficeEmeryvilleCAMember" xlink:to="lab_lgnd_OfficeEmeryvilleCAMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_cff0f6bd-babe-456a-a7cd-05e430029e81_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sublease payments expected to be received, Total</link:label>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" xlink:to="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201409Member_464cbeff-0165-47b5-aa55-42f4d7f4ad66_terseLabel_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201409Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2014-09</link:label>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201409Member_label_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201409Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2014-09 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingStandardsUpdate201409Member" xlink:to="lab_us-gaap_AccountingStandardsUpdate201409Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDerivativeAssets_d7b940d0-4e22-486c-9a29-e3a4c1a0d4d4_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDerivativeAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (decrease) in derivative assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInDerivativeAssets_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInDerivativeAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Derivative Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInDerivativeAssets" xlink:to="lab_us-gaap_IncreaseDecreaseInDerivativeAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsNet_844d5805-14ad-4680-9108-25373be75b5a_totalLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net deferred tax assets</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsNet_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Net of Valuation Allowance</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsNet" xlink:to="lab_us-gaap_DeferredTaxAssetsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpenseMember_b86e69ab-9322-4290-b6ee-d27c7d6d734d_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpenseMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and development expenses</link:label>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpenseMember_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpenseMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and Development Expense [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpenseMember" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpenseMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_bd46580b-84ca-4958-a904-e4768e25f6fa_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible asset with finite life - core technology</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_6f6f30ee-b39a-4847-ac33-a8aff81438fb_terseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">IPR&amp;D</link:label>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indefinite-lived Intangible Assets (Excluding Goodwill)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_ee07c95b-e3fc-402d-9681-2ccbec7c7c5b_terseLabel_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Average cash flow discount rate (as a percent)</link:label>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_label_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Assumptions Used Estimated Future Cash Flows, Average Discount Rate</link:label>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_documentation_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Assumptions Used Estimated Future Cash Flows, Average Discount Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:to="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltyEvomelaMember_d4a5194d-9ed9-48ea-b39b-90ddc54a82fa_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltyEvomelaMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Evomela</link:label>
    <link:label id="lab_lgnd_RoyaltyEvomelaMember_label_en-US" xlink:label="lab_lgnd_RoyaltyEvomelaMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Evomela [Member]</link:label>
    <link:label id="lab_lgnd_RoyaltyEvomelaMember_documentation_en-US" xlink:label="lab_lgnd_RoyaltyEvomelaMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Evomela</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyEvomelaMember" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyEvomelaMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltyEvomelaMember" xlink:to="lab_lgnd_RoyaltyEvomelaMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DirectorMember_e0dba325-accb-419e-8921-3515a86d2e26_terseLabel_en-US" xlink:label="lab_us-gaap_DirectorMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Director</link:label>
    <link:label id="lab_us-gaap_DirectorMember_label_en-US" xlink:label="lab_us-gaap_DirectorMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Director [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectorMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DirectorMember" xlink:to="lab_us-gaap_DirectorMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_a2e0d675-82e0-4926-9388-f4afb861316f_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividend declared (USD per share)</link:label>
    <link:label id="lab_us-gaap_CommonStockDividendsPerShareDeclared_label_en-US" xlink:label="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Dividends, Per Share, Declared</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockDividendsPerShareDeclared" xlink:to="lab_us-gaap_CommonStockDividendsPerShareDeclared" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_8ad27dd7-9e3f-4621-a342-32ad9a7a907c_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock-based compensation</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RevenuesAbstract_9c1f1d94-2313-4001-9a5a-1ef4deb31505_verboseLabel_en-US" xlink:label="lab_us-gaap_RevenuesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenues:</link:label>
    <link:label id="lab_us-gaap_RevenuesAbstract_label_en-US" xlink:label="lab_us-gaap_RevenuesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenues [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenuesAbstract" xlink:to="lab_us-gaap_RevenuesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Assets_e1886081-f36b-4701-8b35-ebe6a5e8e4ab_totalLabel_en-US" xlink:label="lab_us-gaap_Assets" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total assets</link:label>
    <link:label id="lab_us-gaap_Assets_label_en-US" xlink:label="lab_us-gaap_Assets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Assets" xlink:to="lab_us-gaap_Assets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_28d137bb-c4ad-4724-8d95-04d57b668ded_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Estimated fair value</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:to="lab_us-gaap_AvailableForSaleSecuritiesDebtSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_ad8339a2-56b9-4b20-9a76-45191e948de8_verboseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercisable, Weighted Average Remaining Contractual Term in Years</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PlanNameDomain_e4659fc2-190c-41ac-9e77-a81fc3cb8420_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Domain]</link:label>
    <link:label id="lab_us-gaap_PlanNameDomain_label_en-US" xlink:label="lab_us-gaap_PlanNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PlanNameDomain" xlink:to="lab_us-gaap_PlanNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ResearchMember_a6926b42-c98c-4182-8e62-37bd734e7cb0_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Tax Credit Carryforward</link:label>
    <link:label id="lab_us-gaap_ResearchMember_label_en-US" xlink:label="lab_us-gaap_ResearchMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Tax Credit Carryforward [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchMember" xlink:to="lab_us-gaap_ResearchMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_afec79c2-d320-4c5f-b91a-3cfc27833609_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_ed91a021-5c9e-41ff-92cc-1e961df8477b_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other assets</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Noncurrent Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentFiscalPeriodFocus_f29231a6-de7a-4e9a-b573-09e14ba331a8_terseLabel_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Fiscal Period Focus</link:label>
    <link:label id="lab_dei_DocumentFiscalPeriodFocus_label_en-US" xlink:label="lab_dei_DocumentFiscalPeriodFocus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Fiscal Period Focus</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentFiscalPeriodFocus" xlink:to="lab_dei_DocumentFiscalPeriodFocus" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentType_b09606c9-0cee-4553-99dd-313f24538f6b_terseLabel_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Type</link:label>
    <link:label id="lab_dei_DocumentType_label_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Type</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentType"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType" xlink:to="lab_dei_DocumentType" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_6139ccf1-69e9-4318-8743-0913c54bdbc9_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average remaining life in years</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Remaining Contractual Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:to="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeLiabilitiesCurrent_52fc6135-321f-4bab-b038-e90811a1be95_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative liability</link:label>
    <link:label id="lab_us-gaap_DerivativeLiabilitiesCurrent_label_en-US" xlink:label="lab_us-gaap_DerivativeLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Liability, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeLiabilitiesCurrent" xlink:to="lab_us-gaap_DerivativeLiabilitiesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_76f3e534-2b27-486e-886f-b2439a9eff50_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Variable Interest Entities [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Variable Interest Entities [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:to="lab_us-gaap_ScheduleOfVariableInterestEntitiesTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SeniorNotesMember_7e1fa54c-e6f1-41aa-987b-7b0656b728f9_terseLabel_en-US" xlink:label="lab_us-gaap_SeniorNotesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Senior Notes</link:label>
    <link:label id="lab_us-gaap_SeniorNotesMember_label_en-US" xlink:label="lab_us-gaap_SeniorNotesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Senior Notes [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SeniorNotesMember" xlink:to="lab_us-gaap_SeniorNotesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RestrictedCashCurrent_e59999cb-bdb3-4f27-8dcc-a875b81398da_terseLabel_en-US" xlink:label="lab_us-gaap_RestrictedCashCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted cash</link:label>
    <link:label id="lab_us-gaap_RestrictedCashCurrent_label_en-US" xlink:label="lab_us-gaap_RestrictedCashCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted Cash, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestrictedCashCurrent" xlink:to="lab_us-gaap_RestrictedCashCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_fdf6b39a-bf0c-4767-9332-71697fc05314_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax expense</link:label>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_dc29f55f-1be9-41d3-aad3-24c806bf48ee_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax expense from continuing operations</link:label>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_993b5e2b-f071-4a27-a114-b37baf5a7ee1_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax (expense) benefit</link:label>
    <link:label id="lab_us-gaap_IncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_IncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefit" xlink:to="lab_us-gaap_IncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_f35ebf54-af26-4e29-af2c-2202c3757492_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hierarchy and NAV [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Hierarchy and NAV [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:to="lab_us-gaap_FairValueByFairValueHierarchyLevelAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable_3537e33a-75d3-4d8c-8482-983c7abd1c55_terseLabel_en-US" xlink:label="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock and warrant received for repayment of Viking notes receivable</link:label>
    <link:label id="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable_label_en-US" xlink:label="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Received in Repayment of Note Receivable</link:label>
    <link:label id="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable_documentation_en-US" xlink:label="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Received in Repayment of Note Receivable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:href="lgnd-20181231.xsd#lgnd_EquityReceivedinRepaymentofNoteReceivable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:to="lab_lgnd_EquityReceivedinRepaymentofNoteReceivable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesCurrent_72ce9a40-bd3c-424c-9ece-ad9dc3f22572_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total current liabilities</link:label>
    <link:label id="lab_us-gaap_LiabilitiesCurrent_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrent" xlink:to="lab_us-gaap_LiabilitiesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AziyoMember_af916007-4e7c-49f5-b610-2783cc0878b7_terseLabel_en-US" xlink:label="lab_lgnd_AziyoMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo</link:label>
    <link:label id="lab_lgnd_AziyoMember_label_en-US" xlink:label="lab_lgnd_AziyoMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo [Member]</link:label>
    <link:label id="lab_lgnd_AziyoMember_documentation_en-US" xlink:label="lab_lgnd_AziyoMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoMember" xlink:href="lgnd-20181231.xsd#lgnd_AziyoMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AziyoMember" xlink:to="lab_lgnd_AziyoMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights_f122b9de-56c1-4789-bb2e-850fbaaecdbb_terseLabel_en-US" xlink:label="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current contingent liabilities</link:label>
    <link:label id="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights_label_en-US" xlink:label="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Portion of Liability for Contingent Value Rights</link:label>
    <link:label id="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights_documentation_en-US" xlink:label="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current portion of liability for contingent value rights.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:href="lgnd-20181231.xsd#lgnd_CurrentPortionOfLiabilityForContingentValueRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:to="lab_lgnd_CurrentPortionOfLiabilityForContingentValueRights" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ReceivablesNetCurrent_22034906-643e-4007-9dea-692b0bc6248d_verboseLabel_en-US" xlink:label="lab_us-gaap_ReceivablesNetCurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts receivable, net</link:label>
    <link:label id="lab_us-gaap_ReceivablesNetCurrent_label_en-US" xlink:label="lab_us-gaap_ReceivablesNetCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Receivables, Net, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ReceivablesNetCurrent" xlink:to="lab_us-gaap_ReceivablesNetCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201609Member_05cad6a4-a921-435f-8c5c-9adad2b212c8_terseLabel_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201609Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-09</link:label>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201609Member_label_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201609Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-09 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201609Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201609Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingStandardsUpdate201609Member" xlink:to="lab_us-gaap_AccountingStandardsUpdate201609Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_1a2a41ac-29d2-4ffd-b65a-e01700c7badd_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Type [Domain]</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment, Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_9064257e-e3b8-4e67-8210-b699116e9dae_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Principal amount outstanding</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentFaceAmount_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentFaceAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Face Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentFaceAmount" xlink:to="lab_us-gaap_DebtInstrumentFaceAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_8d9308ae-0270-4eb3-8e00-a5b5da32e74f_terseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized tax benefits that would impact effective tax rate</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized Tax Benefits that Would Impact Effective Tax Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:to="lab_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_7d07aca3-6951-41f3-bb5e-e9c53ea65dad_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:label id="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_label_en-US" xlink:label="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:to="lab_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_2a5eaba8-e51d-4230-994b-9b10a06aa5ac_terseLabel_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $15 million with Three Collaboration Agreements</link:label>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_label_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $15 million with Three Collaboration Agreements [Member]</link:label>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_documentation_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $15 million with Three Collaboration Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:to="lab_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LicensingAgreementsMember_26ba33d1-b0f8-4322-a33a-999c24762743_terseLabel_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Licensing Agreements</link:label>
    <link:label id="lab_us-gaap_LicensingAgreementsMember_label_en-US" xlink:label="lab_us-gaap_LicensingAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Licensing Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LicensingAgreementsMember" xlink:to="lab_us-gaap_LicensingAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_07363349-d431-49fa-ab9c-d3ebafebe77f_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from maturity of short-term investments</link:label>
    <link:label id="lab_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_label_en-US" xlink:label="lab_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Maturities, Prepayments and Calls of Short-term Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:to="lab_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_938814b7-9520-4c46-963e-b343f25fad7c_terseLabel_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:label id="lab_dei_EntityCommonStockSharesOutstanding_label_en-US" xlink:label="lab_dei_EntityCommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Common Stock, Shares Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCommonStockSharesOutstanding" xlink:to="lab_dei_EntityCommonStockSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_cf0e9041-5f1a-4411-ab7b-ff6624bbba8b_terseLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, 1-2 years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in One and Two Years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in One and Two Years</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ComputerEquipmentAndSoftwareMember_1f3c4a34-288c-4c00-8a26-5f2d0c21f4f4_verboseLabel_en-US" xlink:label="lab_lgnd_ComputerEquipmentAndSoftwareMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Computer equipment and software</link:label>
    <link:label id="lab_lgnd_ComputerEquipmentAndSoftwareMember_label_en-US" xlink:label="lab_lgnd_ComputerEquipmentAndSoftwareMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Computer Equipment And Software [Member]</link:label>
    <link:label id="lab_lgnd_ComputerEquipmentAndSoftwareMember_documentation_en-US" xlink:label="lab_lgnd_ComputerEquipmentAndSoftwareMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Computer equipment and software.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ComputerEquipmentAndSoftwareMember" xlink:href="lgnd-20181231.xsd#lgnd_ComputerEquipmentAndSoftwareMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ComputerEquipmentAndSoftwareMember" xlink:to="lab_lgnd_ComputerEquipmentAndSoftwareMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_97374e1e-8634-4ac6-bd0d-575f2a366e5f_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Granted (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_493deba6-f6da-4d00-813e-553769725562_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forfeited (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_d9207c9f-bb84-45e3-98f0-c1440d20af13_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Stock Option Weighted-Average Assumptions</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AwardTypeAxis_4fa2b02d-1f2c-4f72-92d1-9ea2e1868363_terseLabel_en-US" xlink:label="lab_us-gaap_AwardTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Type [Axis]</link:label>
    <link:label id="lab_us-gaap_AwardTypeAxis_label_en-US" xlink:label="lab_us-gaap_AwardTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AwardTypeAxis" xlink:to="lab_us-gaap_AwardTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RepurchaseAgreementCounterpartyNameDomain_244bea1a-18a5-4c88-b271-3394d4df65b0_terseLabel_en-US" xlink:label="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:label id="lab_srt_RepurchaseAgreementCounterpartyNameDomain_label_en-US" xlink:label="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:to="lab_srt_RepurchaseAgreementCounterpartyNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_90a95f02-7c44-4cf9-8d2e-ac4a52a01731_terseLabel_en-US" xlink:label="lab_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]</link:label>
    <link:label id="lab_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_label_en-US" xlink:label="lab_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:to="lab_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VernalisMember_310d294f-e0e1-4937-b377-bc6b219079db_terseLabel_en-US" xlink:label="lab_lgnd_VernalisMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vernalis</link:label>
    <link:label id="lab_lgnd_VernalisMember_label_en-US" xlink:label="lab_lgnd_VernalisMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vernalis [Member]</link:label>
    <link:label id="lab_lgnd_VernalisMember_documentation_en-US" xlink:label="lab_lgnd_VernalisMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vernalis</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VernalisMember" xlink:to="lab_lgnd_VernalisMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueOptionChangesInFairValueGainLoss1_a209349c-fb9e-47a6-8bfd-b66dd822d4f0_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain on changes in fair value</link:label>
    <link:label id="lab_us-gaap_FairValueOptionChangesInFairValueGainLoss1_label_en-US" xlink:label="lab_us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Option, Changes in Fair Value, Gain (Loss)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:to="lab_us-gaap_FairValueOptionChangesInFairValueGainLoss1" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_92e0455b-7764-40fe-b7f1-65b2251b1d5c_terseLabel_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Projected cash flow discount rate (as a percent)</link:label>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_label_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Assumptions Used Estimated Future Cash Flows, Discount Rate</link:label>
    <link:label id="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_documentation_en-US" xlink:label="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Assumptions Used Estimated Future Cash Flows, Discount Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:to="lab_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MunicipalBondsMember_0de9a576-75b8-44f9-924d-4d86ea51ef57_terseLabel_en-US" xlink:label="lab_us-gaap_MunicipalBondsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Municipal bonds</link:label>
    <link:label id="lab_us-gaap_MunicipalBondsMember_label_en-US" xlink:label="lab_us-gaap_MunicipalBondsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Municipal Bonds [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalBondsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MunicipalBondsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MunicipalBondsMember" xlink:to="lab_us-gaap_MunicipalBondsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationAbstract_c9b987fd-2e0c-4d06-8468-9154fafb718a_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationAbstract_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract" xlink:to="lab_us-gaap_ShareBasedCompensationAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RestructuringReserveCurrent_d23e749b-34b7-42e5-aa3e-68bf5e68ddc1_terseLabel_en-US" xlink:label="lab_us-gaap_RestructuringReserveCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restructuring</link:label>
    <link:label id="lab_us-gaap_RestructuringReserveCurrent_label_en-US" xlink:label="lab_us-gaap_RestructuringReserveCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restructuring Reserve, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RestructuringReserveCurrent" xlink:to="lab_us-gaap_RestructuringReserveCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredFinanceCostsGross_2ccf536a-1fbf-4736-9747-6ef351f079c0_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsGross" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt issuance costs</link:label>
    <link:label id="lab_us-gaap_DeferredFinanceCostsGross_label_en-US" xlink:label="lab_us-gaap_DeferredFinanceCostsGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Issuance Costs, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFinanceCostsGross" xlink:to="lab_us-gaap_DeferredFinanceCostsGross" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_0e8b19de-44c8-420f-9ea4-971e83d3e098_terseLabel_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent liabilities - Crystal</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_label_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Crystal [Member]</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_documentation_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Crystal [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCrystalMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:to="lab_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_ea6fb017-47d3-4dc8-a2cd-183e8e69b55f_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Upper range of exercise prices (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_329ef18c-79c3-4157-b44a-cbcbc67795bc_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred revenue</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Deferred Revenue</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_3acb1b42-3bd1-4ffa-a223-630e1e5999d7_negatedTerseLabel_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Identified indefinite lived intangibles</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_label_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Indefinite-Lived Intangible Assets</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_documentation_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Indefinite-Lived Intangible Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:to="lab_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OtherAssetsCurrentOther_93ebf00c-a288-41f8-aa07-a15bffb89102_terseLabel_en-US" xlink:label="lab_lgnd_OtherAssetsCurrentOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_lgnd_OtherAssetsCurrentOther_label_en-US" xlink:label="lab_lgnd_OtherAssetsCurrentOther" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets, Current, Other</link:label>
    <link:label id="lab_lgnd_OtherAssetsCurrentOther_documentation_en-US" xlink:label="lab_lgnd_OtherAssetsCurrentOther" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets, Current, Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherAssetsCurrentOther" xlink:href="lgnd-20181231.xsd#lgnd_OtherAssetsCurrentOther"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OtherAssetsCurrentOther" xlink:to="lab_lgnd_OtherAssetsCurrentOther" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_1acd33b4-04f1-4bf0-b9dd-d83c96800aa2_terseLabel_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone payment received</link:label>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_label_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Recognition, Milestone Method Milestone Payment Received</link:label>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_documentation_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Recognition, Milestone Method Milestone Payment Received</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:to="lab_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_ff5fe8f6-92d5-4cb1-a40f-2915b94f9c0f_periodStartLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at beginning of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_145cc009-76af-44f0-96c0-97ae49d9ef67_periodEndLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at end of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_5a78116f-e257-4e83-b86d-0ee5ea576d7e_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash payment received as partial repayment of note receivable</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxesPaid_a71abd8a-b915-4838-a056-00d3befd7ab4_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Taxes paid</link:label>
    <link:label id="lab_us-gaap_IncomeTaxesPaid_label_en-US" xlink:label="lab_us-gaap_IncomeTaxesPaid" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Taxes Paid</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaid" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaid"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxesPaid" xlink:to="lab_us-gaap_IncomeTaxesPaid" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_EmployeeStockPurchasePlanAbstract_8ef07720-d70b-4021-83d6-3366ff031841_terseLabel_en-US" xlink:label="lab_lgnd_EmployeeStockPurchasePlanAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock Purchase Plan</link:label>
    <link:label id="lab_lgnd_EmployeeStockPurchasePlanAbstract_label_en-US" xlink:label="lab_lgnd_EmployeeStockPurchasePlanAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock Purchase Plan [Abstract]</link:label>
    <link:label id="lab_lgnd_EmployeeStockPurchasePlanAbstract_documentation_en-US" xlink:label="lab_lgnd_EmployeeStockPurchasePlanAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Stock Purchase Plan [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EmployeeStockPurchasePlanAbstract" xlink:href="lgnd-20181231.xsd#lgnd_EmployeeStockPurchasePlanAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_EmployeeStockPurchasePlanAbstract" xlink:to="lab_lgnd_EmployeeStockPurchasePlanAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_4337c12b-5daf-4c24-b48c-35ce685353ba_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award vesting right (as a percent)</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncreaseDecreaseInContingentLiabilities_6cbc0212-4624-467b-833a-875d01b42241_terseLabel_en-US" xlink:label="lab_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent liabilities</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseInContingentLiabilities_label_en-US" xlink:label="lab_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Contingent Liabilities</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseInContingentLiabilities_documentation_en-US" xlink:label="lab_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Contingent Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseInContingentLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:to="lab_lgnd_IncreaseDecreaseInContingentLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CurrentIncomeTaxExpenseBenefit_c929153c-f837-4f3f-9371-a9afd11b1583_totalLabel_en-US" xlink:label="lab_us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total Current Income Tax Benefit</link:label>
    <link:label id="lab_us-gaap_CurrentIncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:to="lab_us-gaap_CurrentIncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetIncomeLoss_211a903c-2b48-4f7e-9e9b-1c7bbff3edc5_totalLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss)</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_e82a3a93-0fd4-4d43-9038-87a13efaea8a_verboseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss)</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_b5f0aebb-5697-4ec6-90e6-8c9e58343cbd_terseLabel_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Income (loss)</link:label>
    <link:label id="lab_us-gaap_NetIncomeLoss_label_en-US" xlink:label="lab_us-gaap_NetIncomeLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Income (Loss) Attributable to Parent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetIncomeLoss" xlink:to="lab_us-gaap_NetIncomeLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_d4117f36-ec99-4f1a-aae8-5ce673ca3ac5_totalLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income before income tax expense</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsOther_3c139ff2-26f6-410b-bb9f-90dead16793f_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsOther_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsOther" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsOther" xlink:to="lab_us-gaap_DeferredTaxAssetsOther" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardAmount_63c7ea2c-65de-4c3a-b6b6-cf8c88903946_terseLabel_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardAmount" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax credit carryforward</link:label>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardAmount_label_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardAmount" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credit Carryforward, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TaxCreditCarryforwardAmount" xlink:to="lab_us-gaap_TaxCreditCarryforwardAmount" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BasisOfPresentationTable_c31a5333-94c8-4a2c-b6cb-7b639193cb67_terseLabel_en-US" xlink:label="lab_lgnd_BasisOfPresentationTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation [Table]</link:label>
    <link:label id="lab_lgnd_BasisOfPresentationTable_label_en-US" xlink:label="lab_lgnd_BasisOfPresentationTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation [Table]</link:label>
    <link:label id="lab_lgnd_BasisOfPresentationTable_documentation_en-US" xlink:label="lab_lgnd_BasisOfPresentationTable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationTable" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BasisOfPresentationTable" xlink:to="lab_lgnd_BasisOfPresentationTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationTextBlock_2379c5a8-950e-431c-9403-dcd62b209df9_terseLabel_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Summary of Unaudited Quarterly Financial Information</link:label>
    <link:label id="lab_us-gaap_QuarterlyFinancialInformationTextBlock_label_en-US" xlink:label="lab_us-gaap_QuarterlyFinancialInformationTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Quarterly Financial Information [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_QuarterlyFinancialInformationTextBlock" xlink:to="lab_us-gaap_QuarterlyFinancialInformationTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_1e625d0b-e0a6-4253-8742-c1f2cc51a119_terseLabel_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Well-Known Seasoned Issuer</link:label>
    <link:label id="lab_dei_EntityWellKnownSeasonedIssuer_label_en-US" xlink:label="lab_dei_EntityWellKnownSeasonedIssuer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Well-known Seasoned Issuer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityWellKnownSeasonedIssuer" xlink:to="lab_dei_EntityWellKnownSeasonedIssuer" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CustomerConcentrationRiskMember_940305d5-7f3a-46b4-917f-2419ab6bb0b1_terseLabel_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer Concentration Risk</link:label>
    <link:label id="lab_us-gaap_CustomerConcentrationRiskMember_label_en-US" xlink:label="lab_us-gaap_CustomerConcentrationRiskMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer Concentration Risk [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CustomerConcentrationRiskMember" xlink:to="lab_us-gaap_CustomerConcentrationRiskMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_ee57d439-204d-485f-b58a-b01386bd0541_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Line Items]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_label_en-US" xlink:label="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:to="lab_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CorMatrixMember_64bdf3d9-a2c5-467b-b305-dab76a9ec16f_terseLabel_en-US" xlink:label="lab_lgnd_CorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CorMatrix</link:label>
    <link:label id="lab_lgnd_CorMatrixMember_label_en-US" xlink:label="lab_lgnd_CorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CorMatrix [Member]</link:label>
    <link:label id="lab_lgnd_CorMatrixMember_documentation_en-US" xlink:label="lab_lgnd_CorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">CorMatrix [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorMatrixMember" xlink:href="lgnd-20181231.xsd#lgnd_CorMatrixMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CorMatrixMember" xlink:to="lab_lgnd_CorMatrixMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_be41e467-e51d-40ed-8aac-dd79c7aa8ed1_terseLabel_en-US" xlink:label="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective interest rate of forecasted cash flows (as a percent)</link:label>
    <link:label id="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_label_en-US" xlink:label="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forecasted Cash Flows, Effective Interest Rate, Percent</link:label>
    <link:label id="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_documentation_en-US" xlink:label="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forecasted Cash Flows, Effective Interest Rate, Percent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:href="lgnd-20181231.xsd#lgnd_ForecastedCashFlowsEffectiveInterestRatePercent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:to="lab_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_cb6fd2ba-3a82-4f05-8d64-c797d760ab30_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense, 2021</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Year Three</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OMTInc.Member_c1411e62-39e5-4f4b-bce9-720f285932b6_terseLabel_en-US" xlink:label="lab_lgnd_OMTInc.Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OMT</link:label>
    <link:label id="lab_lgnd_OMTInc.Member_label_en-US" xlink:label="lab_lgnd_OMTInc.Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OMT, Inc. [Member]</link:label>
    <link:label id="lab_lgnd_OMTInc.Member_documentation_en-US" xlink:label="lab_lgnd_OMTInc.Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">OMT, Inc. [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OMTInc.Member" xlink:to="lab_lgnd_OMTInc.Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_d4d39493-ed2b-4dab-a234-be0c3cc676e2_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forfeited (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MeasurementInputPriceVolatilityMember_18ebdb19-9eaa-4c2d-8986-343b0d263fe5_terseLabel_en-US" xlink:label="lab_us-gaap_MeasurementInputPriceVolatilityMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Volatility</link:label>
    <link:label id="lab_us-gaap_MeasurementInputPriceVolatilityMember_label_en-US" xlink:label="lab_us-gaap_MeasurementInputPriceVolatilityMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Price Volatility [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MeasurementInputPriceVolatilityMember" xlink:to="lab_us-gaap_MeasurementInputPriceVolatilityMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_02e1058c-91a1-467c-85bb-e78fa4f8b0a9_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Redemption Period One</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period One [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodOneMember" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_CounterpartyNameAxis_49ddc2bb-4094-40c5-8394-3b2cbf49f199_terseLabel_en-US" xlink:label="lab_srt_CounterpartyNameAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:label id="lab_srt_CounterpartyNameAxis_label_en-US" xlink:label="lab_srt_CounterpartyNameAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Counterparty Name [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_CounterpartyNameAxis" xlink:to="lab_srt_CounterpartyNameAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ContingentLiabilityRollForward_7ff33f72-042d-4764-89a7-942c6ad4c3ea_terseLabel_en-US" xlink:label="lab_lgnd_ContingentLiabilityRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent Liability [Roll Forward]</link:label>
    <link:label id="lab_lgnd_ContingentLiabilityRollForward_label_en-US" xlink:label="lab_lgnd_ContingentLiabilityRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent Liability [Roll Forward]</link:label>
    <link:label id="lab_lgnd_ContingentLiabilityRollForward_documentation_en-US" xlink:label="lab_lgnd_ContingentLiabilityRollForward" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent Liability [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ContingentLiabilityRollForward" xlink:href="lgnd-20181231.xsd#lgnd_ContingentLiabilityRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ContingentLiabilityRollForward" xlink:to="lab_lgnd_ContingentLiabilityRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_1d1155b7-fef2-42ed-b5d8-91a9e3af986e_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award vesting period</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareDilutedAbstract_56de716e-fa29-4b4a-98dc-3fbc6d7d24f5_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Diluted per share amounts:</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDilutedAbstract_34da257c-e9b1-4461-a0e4-d1f9b4c54747_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Diluted per share amounts:</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDilutedAbstract_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract" xlink:to="lab_us-gaap_EarningsPerShareDilutedAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_577f16b7-a939-48b0-a681-0ac6f93a3d3e_terseLabel_en-US" xlink:label="lab_us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">State</link:label>
    <link:label id="lab_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current State and Local Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:to="lab_us-gaap_CurrentStateAndLocalTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_424d0729-0a75-46e0-af22-71a990bf579c_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred revenue</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Contract with Customer, Liability</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:to="lab_us-gaap_IncreaseDecreaseInContractWithCustomerLiability" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_671b684e-b38a-4793-ba21-0569a3747b6a_terseLabel_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Agency bonds</link:label>
    <link:label id="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Government Agencies Debt Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:to="lab_us-gaap_USGovernmentAgenciesDebtSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharePrice_b7ad59b7-1c9e-46d3-9db9-f76de0c113aa_verboseLabel_en-US" xlink:label="lab_us-gaap_SharePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock price (USD per share)</link:label>
    <link:label id="lab_us-gaap_SharePrice_a0dad2fe-c8c6-4d25-a5ce-3135896b4b50_terseLabel_en-US" xlink:label="lab_us-gaap_SharePrice" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock price (USD per share)</link:label>
    <link:label id="lab_us-gaap_SharePrice_label_en-US" xlink:label="lab_us-gaap_SharePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharePrice" xlink:to="lab_us-gaap_SharePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeTenMember_816e20db-2369-4db1-b02d-4e77f583e89a_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTenMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$85.79 - $100.38</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeTenMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTenMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Ten [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeTenMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTenMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Ten [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTenMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTenMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeTenMember" xlink:to="lab_lgnd_ExercisePriceRangeTenMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_a4574d31-c6e8-4417-a6f3-a0327b4e8af5_periodStartLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding at beginning of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_08d1ac73-774f-4619-8975-b5a3ff349c3d_periodEndLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Outstanding at end of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_510ccb8a-69a8-4112-a2e5-261b50c77cf4_terseLabel_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total revenues</link:label>
    <link:label id="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_label_en-US" xlink:label="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue from Contract with Customer, Excluding Assessed Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:to="lab_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LeasesOperatingAbstract_2289d4b6-719c-4ba9-9063-455a1eaffae6_terseLabel_en-US" xlink:label="lab_us-gaap_LeasesOperatingAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments expected to received from sublease agreements</link:label>
    <link:label id="lab_us-gaap_LeasesOperatingAbstract_label_en-US" xlink:label="lab_us-gaap_LeasesOperatingAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leases, Operating [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesOperatingAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOperatingAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeasesOperatingAbstract" xlink:to="lab_us-gaap_LeasesOperatingAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_OwnershipDomain_47ca8228-e03c-4b1d-b89f-d868715e7669_terseLabel_en-US" xlink:label="lab_srt_OwnershipDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership [Domain]</link:label>
    <link:label id="lab_srt_OwnershipDomain_label_en-US" xlink:label="lab_srt_OwnershipDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_OwnershipDomain" xlink:to="lab_srt_OwnershipDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesInvestments_727ea2ac-897f-4bdc-af5a-32d569a00deb_negatedLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking</link:label>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesInvestments_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesInvestments" xlink:to="lab_us-gaap_DeferredTaxLiabilitiesInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_e55cd388-98d6-4b4c-b564-f89b877870a5_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax at federal statutory rate</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:to="lab_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_8ad2477d-efd9-49b0-818f-ff2fbfa6706f_terseLabel_en-US" xlink:label="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional revenue royalty payable when higher threshold of Cydex-related revenue met (percent)</link:label>
    <link:label id="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_label_en-US" xlink:label="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Revenue Royalty to Acquiree Shareholders, Percent</link:label>
    <link:label id="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_documentation_en-US" xlink:label="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Revenue Royalty to Acquiree Shareholders, Percent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:to="lab_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_c802af8b-5afe-4c22-bf7e-1f13b85d5889_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal</link:label>
    <link:label id="lab_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Federal Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:to="lab_us-gaap_DeferredFederalIncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_5e602cf9-5235-4dd0-8b84-463347d22a4c_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) Per Share</link:label>
    <link:label id="lab_us-gaap_EarningsPerSharePolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_EarningsPerSharePolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerSharePolicyTextBlock" xlink:to="lab_us-gaap_EarningsPerSharePolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeContractTypeDomain_f97875c3-e9b8-4d94-b3ee-c8b2d678bf88_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:label id="lab_us-gaap_DerivativeContractTypeDomain_label_en-US" xlink:label="lab_us-gaap_DerivativeContractTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Contract [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeContractTypeDomain" xlink:to="lab_us-gaap_DerivativeContractTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RelatedPartyDomain_d3b3562a-4dfb-4aea-a370-292110aaff96_terseLabel_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party [Domain]</link:label>
    <link:label id="lab_us-gaap_RelatedPartyDomain_label_en-US" xlink:label="lab_us-gaap_RelatedPartyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Related Party [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RelatedPartyDomain" xlink:to="lab_us-gaap_RelatedPartyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_9e2d89f5-3267-4140-8485-a1557bbdf5a7_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income from discontinued operations (USD per share)</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:to="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_85e2023d-13d4-496a-83c1-cdd798ee2644_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercised (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleTable_cdca4d69-bb35-4219-b58d-3e18407edc9d_terseLabel_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Table]</link:label>
    <link:label id="lab_us-gaap_DebtSecuritiesAvailableForSaleTable_label_en-US" xlink:label="lab_us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:to="lab_us-gaap_DebtSecuritiesAvailableForSaleTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsCurrentAbstract_b13cd7cb-788a-4892-acce-fe0e2d01a5cb_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current assets:</link:label>
    <link:label id="lab_us-gaap_AssetsCurrentAbstract_label_en-US" xlink:label="lab_us-gaap_AssetsCurrentAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Current [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrentAbstract" xlink:to="lab_us-gaap_AssetsCurrentAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_d0fbee41-12a3-4223-bf8c-f58498345ef0_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosures [Table]</link:label>
    <link:label id="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_label_en-US" xlink:label="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Instruments and Hedging Activities Disclosures [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable" xlink:to="lab_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Comprehensive Income [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:to="lab_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromStockOptionsExercised_8e7a6954-602a-484f-8408-4bdf6a11fb7d_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromStockOptionsExercised" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net proceeds from stock option exercises and ESPP</link:label>
    <link:label id="lab_us-gaap_ProceedsFromStockOptionsExercised_label_en-US" xlink:label="lab_us-gaap_ProceedsFromStockOptionsExercised" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Stock Options Exercised</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromStockOptionsExercised" xlink:to="lab_us-gaap_ProceedsFromStockOptionsExercised" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent_9d162d74-96e2-4d8d-a521-1b6822ed703f_terseLabel_en-US" xlink:label="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amount of loan to be repaid upon consummation of first capital financing transaction</link:label>
    <link:label id="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent_label_en-US" xlink:label="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Note Receivable, Amount Due Upon Triggering Event</link:label>
    <link:label id="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent_documentation_en-US" xlink:label="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Note Receivable, Amount Due Upon Triggering Event</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableAmountDueUponTriggeringEvent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:to="lab_lgnd_NoteReceivableAmountDueUponTriggeringEvent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_80bdaf71-55be-4dd1-b4b0-36ce95212679_terseLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts payable and accrued liabilities</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Accounts Payable and Accrued Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TradeNamesMember_ec761489-6376-4474-a280-3cb51c1aaa0d_verboseLabel_en-US" xlink:label="lab_us-gaap_TradeNamesMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trade name</link:label>
    <link:label id="lab_us-gaap_TradeNamesMember_label_en-US" xlink:label="lab_us-gaap_TradeNamesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trade Names [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradeNamesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TradeNamesMember" xlink:to="lab_us-gaap_TradeNamesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MeasurementInputRiskFreeInterestRateMember_769e55af-a167-4386-8e2f-e31bf12cc0b8_terseLabel_en-US" xlink:label="lab_us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Risk-free interest rate</link:label>
    <link:label id="lab_us-gaap_MeasurementInputRiskFreeInterestRateMember_label_en-US" xlink:label="lab_us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Risk Free Interest Rate [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:to="lab_us-gaap_MeasurementInputRiskFreeInterestRateMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromCollectionOfNotesReceivable_56799ee6-5b67-432d-8664-f867a243c63e_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromCollectionOfNotesReceivable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds received from repayment of Viking note receivable</link:label>
    <link:label id="lab_us-gaap_ProceedsFromCollectionOfNotesReceivable_label_en-US" xlink:label="lab_us-gaap_ProceedsFromCollectionOfNotesReceivable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Collection of Notes Receivable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable" xlink:to="lab_us-gaap_ProceedsFromCollectionOfNotesReceivable" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CommercialLicenseRights_33e22ca5-1438-4173-b84f-3dd208618b3d_terseLabel_en-US" xlink:label="lab_lgnd_CommercialLicenseRights" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial license rights</link:label>
    <link:label id="lab_lgnd_CommercialLicenseRights_label_en-US" xlink:label="lab_lgnd_CommercialLicenseRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial License Rights</link:label>
    <link:label id="lab_lgnd_CommercialLicenseRights_documentation_en-US" xlink:label="lab_lgnd_CommercialLicenseRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial License Rights</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CommercialLicenseRights" xlink:href="lgnd-20181231.xsd#lgnd_CommercialLicenseRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CommercialLicenseRights" xlink:to="lab_lgnd_CommercialLicenseRights" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltyOtherMember_c6c70534-bdbb-4bdb-9632-15f9bb17045e_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltyOtherMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Other</link:label>
    <link:label id="lab_lgnd_RoyaltyOtherMember_label_en-US" xlink:label="lab_lgnd_RoyaltyOtherMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Other [Member]</link:label>
    <link:label id="lab_lgnd_RoyaltyOtherMember_documentation_en-US" xlink:label="lab_lgnd_RoyaltyOtherMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyOtherMember" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyOtherMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltyOtherMember" xlink:to="lab_lgnd_RoyaltyOtherMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationsPolicy_87534d05-ec22-4f7d-8d2f-2c22ed9b720c_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combinations</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationsPolicy_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationsPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combinations Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsPolicy" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationsPolicy" xlink:to="lab_us-gaap_BusinessCombinationsPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightOutstanding_3c61265a-23c4-416a-8312-7b71a471e430_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants outstanding (in shares)</link:label>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightOutstanding_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Warrant or Right, Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:to="lab_us-gaap_ClassOfWarrantOrRightOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_fb6c8f4d-c5de-4cb7-a9ce-52f8087ddd4e_terseLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sublease payments expected to be received, 1-2 years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in One and Two Years</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in One and Two Years</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DocumentAndEntityInformationAbstract_label_en-US" xlink:label="lab_lgnd_DocumentAndEntityInformationAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document and Entity Information [Abstract]</link:label>
    <link:label id="lab_lgnd_DocumentAndEntityInformationAbstract_documentation_en-US" xlink:label="lab_lgnd_DocumentAndEntityInformationAbstract" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document and entity information.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DocumentAndEntityInformationAbstract" xlink:href="lgnd-20181231.xsd#lgnd_DocumentAndEntityInformationAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract" xlink:to="lab_lgnd_DocumentAndEntityInformationAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_MaximumMember_fae580c3-6e69-440c-b00c-fe81b103eee9_terseLabel_en-US" xlink:label="lab_srt_MaximumMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum</link:label>
    <link:label id="lab_srt_MaximumMember_label_en-US" xlink:label="lab_srt_MaximumMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MaximumMember" xlink:to="lab_srt_MaximumMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeElevenMember_cf8d788e-a726-4fe7-955b-f4fb02e46de8_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeElevenMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$8.58 &#8211; $195.91</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeElevenMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeElevenMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Eleven [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeElevenMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeElevenMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Eleven [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeElevenMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeElevenMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember" xlink:to="lab_lgnd_ExercisePriceRangeElevenMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_6eaab9e6-e185-4b88-8245-78c90eaf8028_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Components of Income Tax Benefit</link:label>
    <link:label id="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_c09f6191-b758-442c-911f-2bfcd6bcd8bc_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Conversion value over the principal amount</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Beneficial Conversion Feature</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature" xlink:to="lab_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeMember_d50704d0-7422-43f1-b7da-5a4603d4aa21_terseLabel_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Range [Domain]</link:label>
    <link:label id="lab_srt_RangeMember_label_en-US" xlink:label="lab_srt_RangeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Range [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeMember" xlink:to="lab_srt_RangeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_133ff05d-e5a3-455c-9a4b-54feca4a632a_totalLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net increase (decrease) in cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_label_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:to="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeAssetsCurrent_9b5b9fa3-bd1e-479b-8b99-6f131a909621_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeAssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative asset</link:label>
    <link:label id="lab_us-gaap_DerivativeAssetsCurrent_label_en-US" xlink:label="lab_us-gaap_DerivativeAssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative Asset, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeAssetsCurrent" xlink:to="lab_us-gaap_DerivativeAssetsCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_3f926f18-7b78-4b71-87fb-8185bc64340d_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:label id="lab_us-gaap_IncomeStatementLocationDomain_label_en-US" xlink:label="lab_us-gaap_IncomeStatementLocationDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement Location [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementLocationDomain" xlink:to="lab_us-gaap_IncomeStatementLocationDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f08d2027-d36a-4a2b-a31e-f359b94e3c96_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Investing Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:to="lab_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_884bb8cb-4969-48f3-a025-5b4116627a1c_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt issuance costs related to the liability component of convertible debt</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentUnamortizedPremium_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Unamortized Premium</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentUnamortizedPremium" xlink:to="lab_us-gaap_DebtInstrumentUnamortizedPremium" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_7e6bb661-bdc9-477e-a165-cca0295e9d32_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (loss) from continuing operations (USD per share)</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Continuing Operations, Per Basic Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_f54e05cd-f0be-4bac-9683-6c6c8f832294_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases of property and equipment</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Property, Plant, and Equipment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:to="lab_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CostOfGoodsAndServicesSoldAmortization_ca23715d-e420-4a7f-8e10-d0c8f3f5a1fa_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsAndServicesSoldAmortization" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of intangibles</link:label>
    <link:label id="lab_us-gaap_CostOfGoodsAndServicesSoldAmortization_label_en-US" xlink:label="lab_us-gaap_CostOfGoodsAndServicesSoldAmortization" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost, Amortization</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSoldAmortization"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization" xlink:to="lab_us-gaap_CostOfGoodsAndServicesSoldAmortization" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_label_en-US" xlink:label="lab_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disclosure of Compensation Related Costs, Share-based Payments [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:to="lab_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsGrossAbstract_7007a86f-7dea-4cf7-a19d-4e46d34c12da_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsGrossAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred assets:</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsGrossAbstract_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsGrossAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Gross [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGrossAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGrossAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract" xlink:to="lab_us-gaap_DeferredTaxAssetsGrossAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskCreditRisk_1f22e043-808e-44b8-b4a2-913f21c5414f_verboseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskCreditRisk" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentrations of Business Risk</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskCreditRisk_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskCreditRisk" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk, Credit Risk, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskCreditRisk" xlink:to="lab_us-gaap_ConcentrationRiskCreditRisk" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_49518abc-c43a-4fd5-81e9-9e17b7e3bdbe_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options vested and expected to vest, Aggregate Intrinsic Value</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_b0aca3af-f10d-4422-8a9b-c5acfbde8100_terseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional paid-in capital</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapitalMember_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Paid-in Capital [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapitalMember" xlink:to="lab_us-gaap_AdditionalPaidInCapitalMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MeasurementInputCouponRateMember_7058e702-1f9d-4c2a-954f-5b31c1ab4a66_terseLabel_en-US" xlink:label="lab_lgnd_MeasurementInputCouponRateMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Annual coupon rate</link:label>
    <link:label id="lab_lgnd_MeasurementInputCouponRateMember_label_en-US" xlink:label="lab_lgnd_MeasurementInputCouponRateMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Coupon Rate [Member]</link:label>
    <link:label id="lab_lgnd_MeasurementInputCouponRateMember_documentation_en-US" xlink:label="lab_lgnd_MeasurementInputCouponRateMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Coupon Rate</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputCouponRateMember" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputCouponRateMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MeasurementInputCouponRateMember" xlink:to="lab_lgnd_MeasurementInputCouponRateMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RealizedInvestmentGainsLosses_b1fba51f-cbdd-42c7-8a0f-117f05c8d992_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_RealizedInvestmentGainsLosses" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Realized gain on sale of short-term investment</link:label>
    <link:label id="lab_us-gaap_RealizedInvestmentGainsLosses_label_en-US" xlink:label="lab_us-gaap_RealizedInvestmentGainsLosses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Realized Investment Gains (Losses)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealizedInvestmentGainsLosses" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RealizedInvestmentGainsLosses"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RealizedInvestmentGainsLosses" xlink:to="lab_us-gaap_RealizedInvestmentGainsLosses" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_3265d34c-2cdf-4fcf-9a53-ea1eaedc633f_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities, fair value</link:label>
    <link:label id="lab_us-gaap_LiabilitiesFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_LiabilitiesFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial and Nonfinancial Liabilities, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure" xlink:to="lab_us-gaap_LiabilitiesFairValueDisclosure" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_21e4bc5d-91dd-4cb0-8e38-c8a2c88d1b7b_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, shares outstanding (shares)</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesOutstanding_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares, Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesOutstanding" xlink:to="lab_us-gaap_CommonStockSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_5ee556b5-d9c3-44b4-900c-8aa9ad203804_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Taxes</link:label>
    <link:label id="lab_us-gaap_IncomeTaxPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_IncomeTaxPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxPolicyTextBlock" xlink:to="lab_us-gaap_IncomeTaxPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_c5bd8a0f-f3fb-4f28-9534-0af44a8a1953_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share repurchases</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfCommonStock_label_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Common Stock</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfCommonStock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHolders_9fe6f9fb-4675-47ba-9f9c-ed8bfba14761_negatedLabel_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHolders" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to CVR holders and other contingency payments</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHolders_7c2ab112-5c5b-4b9c-a399-9416c7a05b96_negatedTerseLabel_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHolders" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHolders_label_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHolders" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Contingent Value Right Holders</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHolders_documentation_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHolders" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to contingent value right holders</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHolders" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHolders"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PaymentsToContingentValueRightHolders" xlink:to="lab_lgnd_PaymentsToContingentValueRightHolders" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_Goodwill_d278a7ca-59b6-412e-8d37-f3912efb5811_verboseLabel_en-US" xlink:label="lab_us-gaap_Goodwill" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill</link:label>
    <link:label id="lab_us-gaap_Goodwill_20460767-8941-449e-8b9d-b169626ae7b9_terseLabel_en-US" xlink:label="lab_us-gaap_Goodwill" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill</link:label>
    <link:label id="lab_us-gaap_Goodwill_label_en-US" xlink:label="lab_us-gaap_Goodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_Goodwill" xlink:to="lab_us-gaap_Goodwill" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_7d695cf8-1c38-4878-980b-552ae0a4ab1d_terseLabel_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_label_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees, Milestones, and Other Product, Other [Member]</link:label>
    <link:label id="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_documentation_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees, Milestones, and Other Product, Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesAndOtherProductOtherMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:to="lab_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PurchaseforCommercialLicenseRights_eeff786e-1aa2-495a-a073-a6cdc952578b_negatedLabel_en-US" xlink:label="lab_lgnd_PurchaseforCommercialLicenseRights" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase of commercial license rights</link:label>
    <link:label id="lab_lgnd_PurchaseforCommercialLicenseRights_label_en-US" xlink:label="lab_lgnd_PurchaseforCommercialLicenseRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase for Commercial License Rights</link:label>
    <link:label id="lab_lgnd_PurchaseforCommercialLicenseRights_documentation_en-US" xlink:label="lab_lgnd_PurchaseforCommercialLicenseRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchase for Commercial License Rights</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseforCommercialLicenseRights" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseforCommercialLicenseRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PurchaseforCommercialLicenseRights" xlink:to="lab_lgnd_PurchaseforCommercialLicenseRights" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_05699324-47b8-405a-832c-9e071010a249_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign currency translation</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_a7b65148-8cfb-4de7-a7f5-951da7189bfb_negatedLabel_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net change in fair value of derivatives</link:label>
    <link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_389f28e4-310b-43d8-a52b-c6398bc99e01_terseLabel_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (loss) on derivative liabilities</link:label>
    <link:label id="lab_us-gaap_DerivativeGainLossOnDerivativeNet_label_en-US" xlink:label="lab_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Derivative, Gain (Loss) on Derivative, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:to="lab_us-gaap_DerivativeGainLossOnDerivativeNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_8a20ea19-4c63-4bb4-8b3a-9691798b6e71_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options vested and expected to vest at end of period (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_1b60970a-6eb2-485e-aec9-2de909c84e31_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense, 2019</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_febd079d-0dba-4de4-b5c3-2e16dd1d0b41_terseLabel_en-US" xlink:label="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability for restricted investments owed to former licensees</link:label>
    <link:label id="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_label_en-US" xlink:label="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability for Restricted Investments Owed to Former Licensees [Member]</link:label>
    <link:label id="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_documentation_en-US" xlink:label="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability for Restricted Investments Owed to Former Licensees [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:to="lab_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_1f4e0a86-778b-437e-9c50-635beb4ccead_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expected term</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_3793d334-b37b-49af-93b2-e63e639e2968_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalties recorded in retained earnings upon adoption of ASC 606</link:label>
    <link:label id="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_label_en-US" xlink:label="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalties Recorded upon Adoption of New Accounting Pronouncement</link:label>
    <link:label id="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_documentation_en-US" xlink:label="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalties Recorded upon Adoption of New Accounting Pronouncement</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:to="lab_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_d054784d-f187-44d1-a12b-144e68a1c3da_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes receivable fair market value adjustment</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Settlements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RoyaltyKyprolisMember_7948e57b-65ec-4363-bc5e-8eabeea29b24_terseLabel_en-US" xlink:label="lab_lgnd_RoyaltyKyprolisMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Kyprolis</link:label>
    <link:label id="lab_lgnd_RoyaltyKyprolisMember_label_en-US" xlink:label="lab_lgnd_RoyaltyKyprolisMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Kyprolis [Member]</link:label>
    <link:label id="lab_lgnd_RoyaltyKyprolisMember_documentation_en-US" xlink:label="lab_lgnd_RoyaltyKyprolisMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Royalty, Kyprolis</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyKyprolisMember" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyKyprolisMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RoyaltyKyprolisMember" xlink:to="lab_lgnd_RoyaltyKyprolisMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_b10542d7-38c4-44a8-8944-00d88d0e97fe_verboseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (loss) from continuing operations (USD per share)</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Continuing Operations, Per Diluted Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:to="lab_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_65a03d1d-ddcb-4cdb-8429-b9a9834d13c0_verboseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated deficit</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_dd03240e-ad5f-4845-bc0f-fe60cef9758c_terseLabel_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retained earnings (accumulated deficit)</link:label>
    <link:label id="lab_us-gaap_RetainedEarningsAccumulatedDeficit_label_en-US" xlink:label="lab_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retained Earnings (Accumulated Deficit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:to="lab_us-gaap_RetainedEarningsAccumulatedDeficit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MeasurementInputTypeDomain_29902d6b-4bb1-4ccb-9664-b7fa7533e542_terseLabel_en-US" xlink:label="lab_us-gaap_MeasurementInputTypeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input Type [Domain]</link:label>
    <link:label id="lab_us-gaap_MeasurementInputTypeDomain_label_en-US" xlink:label="lab_us-gaap_MeasurementInputTypeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input Type [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MeasurementInputTypeDomain" xlink:to="lab_us-gaap_MeasurementInputTypeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EntityWideRevenueMajorCustomerLineItems_7003260c-a107-4b49-9cac-51262285b996_terseLabel_en-US" xlink:label="lab_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue, Major Customer</link:label>
    <link:label id="lab_us-gaap_EntityWideRevenueMajorCustomerLineItems_label_en-US" xlink:label="lab_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue, Major Customer [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:to="lab_us-gaap_EntityWideRevenueMajorCustomerLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_133b4c68-ddc0-42c0-a3f6-a9d5b97937a7_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:to="lab_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MetabasisTherapeuticsMember_1d897ac3-fa7e-448f-83f1-749dfda053ad_terseLabel_en-US" xlink:label="lab_lgnd_MetabasisTherapeuticsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Metabasis Therapeutics</link:label>
    <link:label id="lab_lgnd_MetabasisTherapeuticsMember_d7103797-91c2-4b3d-9929-63dca755b0ea_verboseLabel_en-US" xlink:label="lab_lgnd_MetabasisTherapeuticsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Metabasis</link:label>
    <link:label id="lab_lgnd_MetabasisTherapeuticsMember_label_en-US" xlink:label="lab_lgnd_MetabasisTherapeuticsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Metabasis Therapeutics [Member]</link:label>
    <link:label id="lab_lgnd_MetabasisTherapeuticsMember_documentation_en-US" xlink:label="lab_lgnd_MetabasisTherapeuticsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Metabasis Therapeutics [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MetabasisTherapeuticsMember" xlink:href="lgnd-20181231.xsd#lgnd_MetabasisTherapeuticsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MetabasisTherapeuticsMember" xlink:to="lab_lgnd_MetabasisTherapeuticsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_017b6f31-fd92-451b-9d9d-569c15d3c287_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Operating Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsEquityMethodInvestments_7dda7e7e-5c70-48f0-ae75-195137b7d538_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsEquityMethodInvestments_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsEquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Equity Method Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsEquityMethodInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments" xlink:to="lab_us-gaap_DeferredTaxAssetsEquityMethodInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_896ff699-fe7c-427c-99d6-6fa4c55fb075_terseLabel_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indefinite-lived Intangible Assets [Axis]</link:label>
    <link:label id="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_label_en-US" xlink:label="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Indefinite-lived Intangible Assets [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="lab_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_4fa7f7ef-ef83-4abd-883c-09cccf5e158e_negatedLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax effect for Notes transactions</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Tax Effect of Convertible Senior Notes Transactions</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Tax Effect of Convertible Senior Notes Transactions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DevelopedTechnologyRightsMember_b9b8b15c-2e54-40e0-b6bf-0073d96d941c_terseLabel_en-US" xlink:label="lab_us-gaap_DevelopedTechnologyRightsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Core Technology</link:label>
    <link:label id="lab_us-gaap_DevelopedTechnologyRightsMember_label_en-US" xlink:label="lab_us-gaap_DevelopedTechnologyRightsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Developed Technology Rights [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DevelopedTechnologyRightsMember" xlink:to="lab_us-gaap_DevelopedTechnologyRightsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_c9b7d050-a3e7-4750-b4b1-c3a59f463538_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combinations</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationDisclosureTextBlock" xlink:to="lab_us-gaap_BusinessCombinationDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_bf766abb-f735-4d5a-852b-4605274aec70_verboseLabel_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Supplemental disclosure of cash flow information</link:label>
    <link:label id="lab_us-gaap_SupplementalCashFlowInformationAbstract_label_en-US" xlink:label="lab_us-gaap_SupplementalCashFlowInformationAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Supplemental Cash Flow Information [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract" xlink:to="lab_us-gaap_SupplementalCashFlowInformationAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_145ef5d3-57aa-4d98-8a40-acc91a96bf0d_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal</link:label>
    <link:label id="lab_us-gaap_AccruedProfessionalFeesCurrent_label_en-US" xlink:label="lab_us-gaap_AccruedProfessionalFeesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Professional Fees, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedProfessionalFeesCurrent" xlink:to="lab_us-gaap_AccruedProfessionalFeesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember_3cfb2180-c500-4eda-83a3-b055eb711b2b_verboseLabel_en-US" xlink:label="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">IPR&amp;D</link:label>
    <link:label id="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember_label_en-US" xlink:label="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Acquired In Process Research And Development [Member]</link:label>
    <link:label id="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember_documentation_en-US" xlink:label="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Acquired in process research and development.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:href="lgnd-20181231.xsd#lgnd_AcquiredInProcessResearchAndDevelopmentMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:to="lab_lgnd_AcquiredInProcessResearchAndDevelopmentMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_fcea258c-bb55-4811-a3e2-d2850509eeee_terseLabel_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notices for conversion</link:label>
    <link:label id="lab_us-gaap_DebtConversionConvertedInstrumentAmount1_label_en-US" xlink:label="lab_us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Conversion, Converted Instrument, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:to="lab_us-gaap_DebtConversionConvertedInstrumentAmount1" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_NameOfMajorCustomerDomain_3a6d7c45-51ed-44dc-b759-7a5fbd95bfe1_terseLabel_en-US" xlink:label="lab_srt_NameOfMajorCustomerDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer [Domain]</link:label>
    <link:label id="lab_srt_NameOfMajorCustomerDomain_label_en-US" xlink:label="lab_srt_NameOfMajorCustomerDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Customer [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_NameOfMajorCustomerDomain" xlink:to="lab_srt_NameOfMajorCustomerDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityPublicFloat_adc6cbcb-b853-4683-9334-10cbe11c0cf7_terseLabel_en-US" xlink:label="lab_dei_EntityPublicFloat" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Public Float</link:label>
    <link:label id="lab_dei_EntityPublicFloat_label_en-US" xlink:label="lab_dei_EntityPublicFloat" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Public Float</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityPublicFloat"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityPublicFloat" xlink:to="lab_dei_EntityPublicFloat" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_3c8c1a70-a695-4337-838e-7dc817a7531f_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Benchmark [Domain]</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskBenchmarkDomain_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskBenchmarkDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk Benchmark [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain" xlink:to="lab_us-gaap_ConcentrationRiskBenchmarkDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromRoyaltiesReceived_e095c4d9-5c41-4140-af22-0726b9421d7a_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromRoyaltiesReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from royalties received</link:label>
    <link:label id="lab_us-gaap_ProceedsFromRoyaltiesReceived_label_en-US" xlink:label="lab_us-gaap_ProceedsFromRoyaltiesReceived" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Royalties Received</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromRoyaltiesReceived" xlink:to="lab_us-gaap_ProceedsFromRoyaltiesReceived" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_11527489-679e-4a4d-aa83-08b7dfb5891b_terseLabel_en-US" xlink:label="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bioscience and Technology Business Center-Lawrence, KS</link:label>
    <link:label id="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_label_en-US" xlink:label="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bioscience and Technology Business Center - Lawrence, KS [Member]</link:label>
    <link:label id="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_documentation_en-US" xlink:label="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bioscience and Technology Business Center - Lawrence, KS [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:href="lgnd-20181231.xsd#lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:to="lab_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock_4d501eba-e55c-472c-8628-d0af7e3c7b87_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Operating Lease Obligations and Payments Expected to be Received from Sublease Agreements</link:label>
    <link:label id="lab_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Property Subject to or Available for Operating Lease [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" xlink:to="lab_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_2edbe2c9-104c-45c1-afec-aaf68f45fdcd_verboseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_840455fb-5cd3-4079-b43e-42499faecaf0_terseLabel_en-US" xlink:label="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instruments [Domain]</link:label>
    <link:label id="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_label_en-US" xlink:label="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instruments [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:to="lab_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_3c55d211-a8c4-4c70-93cc-fdacbbf1cc97_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Actual number of shares issued (shares)</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition, Equity Interest Issued or Issuable, Number of Shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:to="lab_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueTable_a56a5c82-8bb6-4c8f-a4dd-92197fd4db22_terseLabel_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disaggregation of Revenue [Table]</link:label>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueTable_label_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disaggregation of Revenue [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable" xlink:to="lab_us-gaap_DisaggregationOfRevenueTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_64683908-7f52-4dd0-a9fd-beab058d64ec_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other tax reclassifications</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Other</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:to="lab_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsLiabilitiesNet_7509f6a6-22b3-41d2-b717-e0d0a3e43ae2_totalLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsLiabilitiesNet_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:to="lab_us-gaap_DeferredTaxAssetsLiabilitiesNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_85a5dc5f-63f7-431e-8efc-5e1f4bb4aeba_terseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements [Abstract]</link:label>
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsDeferredIncome_33aa2655-93c0-4e3b-b21b-93e6e4c45791_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsDeferredIncome" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred revenue</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsDeferredIncome_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsDeferredIncome" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Deferred Income</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsDeferredIncome" xlink:to="lab_us-gaap_DeferredTaxAssetsDeferredIncome" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeOneMember_c5b6be2a-cc02-4bb9-b856-859368c2b074_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeOneMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$8.58 - $10.05</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeOneMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeOneMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range One [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeOneMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeOneMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range One [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeOneMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeOneMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeOneMember" xlink:to="lab_lgnd_ExercisePriceRangeOneMember" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RangeAxis_2c119937-c253-4d7f-a5ab-fd1b14b25a1b_terseLabel_en-US" xlink:label="lab_srt_RangeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Range [Axis]</link:label>
    <link:label id="lab_srt_RangeAxis_label_en-US" xlink:label="lab_srt_RangeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Range [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RangeAxis" xlink:to="lab_srt_RangeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredIncomeTaxAssetsNet_c926065c-6c47-4cfc-96ef-00b465589f85_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxAssetsNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred income taxes, net</link:label>
    <link:label id="lab_us-gaap_DeferredIncomeTaxAssetsNet_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxAssetsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Income Tax Assets, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxAssetsNet" xlink:to="lab_us-gaap_DeferredIncomeTaxAssetsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_333c4972-8db1-4805-b2df-263481a73232_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average exercise price (USD per share)</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" xlink:to="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessAcquisitionAxis_376a859c-1737-4894-8d43-460945e095ea_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition [Axis]</link:label>
    <link:label id="lab_us-gaap_BusinessAcquisitionAxis_label_en-US" xlink:label="lab_us-gaap_BusinessAcquisitionAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessAcquisitionAxis" xlink:to="lab_us-gaap_BusinessAcquisitionAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AccruedInventoryPurchases_526c2d64-ae78-46b6-a90c-8953bbf6115c_terseLabel_en-US" xlink:label="lab_lgnd_AccruedInventoryPurchases" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued inventory purchases</link:label>
    <link:label id="lab_lgnd_AccruedInventoryPurchases_label_en-US" xlink:label="lab_lgnd_AccruedInventoryPurchases" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Inventory Purchases</link:label>
    <link:label id="lab_lgnd_AccruedInventoryPurchases_documentation_en-US" xlink:label="lab_lgnd_AccruedInventoryPurchases" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Inventory Purchases</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedInventoryPurchases" xlink:href="lgnd-20181231.xsd#lgnd_AccruedInventoryPurchases"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AccruedInventoryPurchases" xlink:to="lab_lgnd_AccruedInventoryPurchases" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_4f1691ac-cf32-4691-8257-63db3f75485b_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes Payable, Current and Noncurrent</link:label>
    <link:label id="lab_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_label_en-US" xlink:label="lab_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes Payable, Current and Noncurrent [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract" xlink:to="lab_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConvertibleDebtNoncurrent_4dca0976-08d4-49cd-8239-bba9f58c775b_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtNoncurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2023 convertible senior notes, net</link:label>
    <link:label id="lab_us-gaap_ConvertibleDebtNoncurrent_fcfad5d8-f2d4-4543-b9e0-218dadd31516_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtNoncurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible debt, noncurrent</link:label>
    <link:label id="lab_us-gaap_ConvertibleDebtNoncurrent_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Debt, Noncurrent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtNoncurrent" xlink:to="lab_us-gaap_ConvertibleDebtNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_10e6b9ec-101c-4ada-a550-82c8fc97263f_verboseLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders&#8217; equity:</link:label>
    <link:label id="lab_us-gaap_StockholdersEquityAbstract_label_en-US" xlink:label="lab_us-gaap_StockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity Attributable to Parent [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquityAbstract" xlink:to="lab_us-gaap_StockholdersEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WarrantsAndRightsOutstanding_4b653f42-1018-4b1e-b095-786cea78586b_terseLabel_en-US" xlink:label="lab_us-gaap_WarrantsAndRightsOutstanding" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants</link:label>
    <link:label id="lab_us-gaap_WarrantsAndRightsOutstanding_label_en-US" xlink:label="lab_us-gaap_WarrantsAndRightsOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants and Rights Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WarrantsAndRightsOutstanding" xlink:to="lab_us-gaap_WarrantsAndRightsOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PartnerBMember_4db41ca3-abde-435c-901b-4d5f8a0a1891_terseLabel_en-US" xlink:label="lab_lgnd_PartnerBMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner B</link:label>
    <link:label id="lab_lgnd_PartnerBMember_label_en-US" xlink:label="lab_lgnd_PartnerBMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner B [Member]</link:label>
    <link:label id="lab_lgnd_PartnerBMember_documentation_en-US" xlink:label="lab_lgnd_PartnerBMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner B [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerBMember" xlink:href="lgnd-20181231.xsd#lgnd_PartnerBMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PartnerBMember" xlink:to="lab_lgnd_PartnerBMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LongtermDebtTypeAxis_ace41091-458f-45bc-aebf-24be45840b02_terseLabel_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Axis]</link:label>
    <link:label id="lab_us-gaap_LongtermDebtTypeAxis_label_en-US" xlink:label="lab_us-gaap_LongtermDebtTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Long-term Debt, Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongtermDebtTypeAxis" xlink:to="lab_us-gaap_LongtermDebtTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MeasurementInputTypeAxis_464ed9e0-be79-4169-9eb3-609aef83811a_terseLabel_en-US" xlink:label="lab_us-gaap_MeasurementInputTypeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input Type [Axis]</link:label>
    <link:label id="lab_us-gaap_MeasurementInputTypeAxis_label_en-US" xlink:label="lab_us-gaap_MeasurementInputTypeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input Type [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MeasurementInputTypeAxis" xlink:to="lab_us-gaap_MeasurementInputTypeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CurrentForeignTaxExpenseBenefit_0ee7d104-3b91-400f-a7e6-487789c29b14_terseLabel_en-US" xlink:label="lab_us-gaap_CurrentForeignTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign</link:label>
    <link:label id="lab_us-gaap_CurrentForeignTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_CurrentForeignTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Foreign Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CurrentForeignTaxExpenseBenefit" xlink:to="lab_us-gaap_CurrentForeignTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_b490a3df-9dd2-4810-84f2-76e1b3f42f2b_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range [Axis]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherAssetsNoncurrent_e0720803-ecd4-4122-894a-a7cf4a583ae5_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other assets</link:label>
    <link:label id="lab_us-gaap_OtherAssetsNoncurrent_label_en-US" xlink:label="lab_us-gaap_OtherAssetsNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets, Noncurrent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsNoncurrent" xlink:to="lab_us-gaap_OtherAssetsNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCurrentReportingStatus_a6b2e6be-e53f-4c93-8f03-56339a1e74cc_terseLabel_en-US" xlink:label="lab_dei_EntityCurrentReportingStatus" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Current Reporting Status</link:label>
    <link:label id="lab_dei_EntityCurrentReportingStatus_label_en-US" xlink:label="lab_dei_EntityCurrentReportingStatus" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Current Reporting Status</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCurrentReportingStatus"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCurrentReportingStatus" xlink:to="lab_dei_EntityCurrentReportingStatus" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_f31a17bf-7a07-43a1-b48f-eb5fe6854969_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of convertible debt</link:label>
    <link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_4baa08e4-bdc4-40a5-887a-5f3b0fe3f4f1_verboseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of convertible senior notes outstanding (Level 2)</link:label>
    <link:label id="lab_us-gaap_ConvertibleDebtFairValueDisclosures_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Debt, Fair Value Disclosures</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:to="lab_us-gaap_ConvertibleDebtFairValueDisclosures" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock_b5849f54-02a1-4fa3-b40a-ad03c9dcbe9d_terseLabel_en-US" xlink:label="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Accounting for Share-Based Compensation</link:label>
    <link:label id="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock_label_en-US" xlink:label="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule For Share Based Compensation Expense for Awards to Employees and Directors [Table Text Block]</link:label>
    <link:label id="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock_documentation_en-US" xlink:label="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule for share based compensation expense for awards to employees and directors.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:to="lab_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_83e27c16-3803-4189-8a90-e025e9f92bd1_totalLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net (loss) income - Diluted (USD per share)</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_9917a9cd-78ba-454d-8cd0-1bc79286df37_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings per share - diluted (USD per share)</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_1af88dd7-d1fe-49ad-b110-58310e6a6ef3_terseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss) - Diluted (USD per share)</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareDiluted_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareDiluted" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Diluted</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareDiluted" xlink:to="lab_us-gaap_EarningsPerShareDiluted" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_4afbc537-6204-42af-8f75-65612469060f_negatedLabel_en-US" xlink:label="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in estimated fair value of contingent liabilities</link:label>
    <link:label id="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_label_en-US" xlink:label="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-cash change in estimated fair value of contingent value rights</link:label>
    <link:label id="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_documentation_en-US" xlink:label="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Non-cash change in estimated fair value of contingent value rights.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:href="lgnd-20181231.xsd#lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:to="lab_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingCostsAndExpensesAbstract_09836ee9-afc5-4bef-bea3-8eca3a79e08a_verboseLabel_en-US" xlink:label="lab_us-gaap_OperatingCostsAndExpensesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating costs and expenses:</link:label>
    <link:label id="lab_us-gaap_OperatingCostsAndExpensesAbstract_label_en-US" xlink:label="lab_us-gaap_OperatingCostsAndExpensesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Costs and Expenses [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpensesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpensesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract" xlink:to="lab_us-gaap_OperatingCostsAndExpensesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PartnerCMember_d46e19c7-19a3-4b89-bb00-37582daf2e64_terseLabel_en-US" xlink:label="lab_lgnd_PartnerCMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner C</link:label>
    <link:label id="lab_lgnd_PartnerCMember_label_en-US" xlink:label="lab_lgnd_PartnerCMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner C [Member]</link:label>
    <link:label id="lab_lgnd_PartnerCMember_documentation_en-US" xlink:label="lab_lgnd_PartnerCMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Partner C [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerCMember" xlink:href="lgnd-20181231.xsd#lgnd_PartnerCMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PartnerCMember" xlink:to="lab_lgnd_PartnerCMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtMember_daf1ac35-aeae-4ba1-a9ee-7f9f84eea2e6_terseLabel_en-US" xlink:label="lab_us-gaap_DebtMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt</link:label>
    <link:label id="lab_us-gaap_DebtMember_label_en-US" xlink:label="lab_us-gaap_DebtMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtMember" xlink:to="lab_us-gaap_DebtMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InventoryNet_364aa316-80ff-496b-ad34-85c43cdc1393_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryNet" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory</link:label>
    <link:label id="lab_us-gaap_InventoryNet_label_en-US" xlink:label="lab_us-gaap_InventoryNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryNet" xlink:to="lab_us-gaap_InventoryNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_36136ed7-956f-4e0e-91b3-a507f14c49db_verboseLabel_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized compensation cost</link:label>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_label_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:to="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions" xlink:type="arc" order="1"/>
    <link:label id="lab_invest_InvestmentWarrantsExercisePrice_f6ab1f09-6b5d-493d-9d2d-bd4d67abdd01_terseLabel_en-US" xlink:label="lab_invest_InvestmentWarrantsExercisePrice" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise price, warrants (USD per share)</link:label>
    <link:label id="lab_invest_InvestmentWarrantsExercisePrice_label_en-US" xlink:label="lab_invest_InvestmentWarrantsExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment Warrants, Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_invest_InvestmentWarrantsExercisePrice" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentWarrantsExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_invest_InvestmentWarrantsExercisePrice" xlink:to="lab_invest_InvestmentWarrantsExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_370358c4-d1d9-4ff8-beb3-fd758ca5ac03_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, Less than 1 year</link:label>
    <link:label id="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_label_en-US" xlink:label="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Next Twelve Months</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:to="lab_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CommercialLicenseRightsPolicyTextBlock_b607a684-23af-4c6b-a2fb-3f030eb3ae5f_terseLabel_en-US" xlink:label="lab_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial license rights</link:label>
    <link:label id="lab_lgnd_CommercialLicenseRightsPolicyTextBlock_label_en-US" xlink:label="lab_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial License Rights [Policy Text Block]</link:label>
    <link:label id="lab_lgnd_CommercialLicenseRightsPolicyTextBlock_documentation_en-US" xlink:label="lab_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial License Rights [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_CommercialLicenseRightsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:to="lab_lgnd_CommercialLicenseRightsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PatentedTechnologyMember_f83157c5-529d-43b8-8183-fd1aadc84899_verboseLabel_en-US" xlink:label="lab_us-gaap_PatentedTechnologyMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Complete technology</link:label>
    <link:label id="lab_us-gaap_PatentedTechnologyMember_label_en-US" xlink:label="lab_us-gaap_PatentedTechnologyMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Patented Technology [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentedTechnologyMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PatentedTechnologyMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PatentedTechnologyMember" xlink:to="lab_us-gaap_PatentedTechnologyMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_dcbd83d3-f4b6-4657-a696-f9ea6c2778a1_terseLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Sublease payments expected to be received, Less than 1 year</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due Next Twelve Months</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due Next Twelve Months</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MeasurementInputRemainingTermMember_4ca928c1-4fea-470c-aa01-b10f7a453e0d_terseLabel_en-US" xlink:label="lab_lgnd_MeasurementInputRemainingTermMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Remaining contractual term (in years)</link:label>
    <link:label id="lab_lgnd_MeasurementInputRemainingTermMember_label_en-US" xlink:label="lab_lgnd_MeasurementInputRemainingTermMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Remaining Term [Member]</link:label>
    <link:label id="lab_lgnd_MeasurementInputRemainingTermMember_documentation_en-US" xlink:label="lab_lgnd_MeasurementInputRemainingTermMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Remaining Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputRemainingTermMember" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputRemainingTermMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MeasurementInputRemainingTermMember" xlink:to="lab_lgnd_MeasurementInputRemainingTermMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock_60bb4171-6373-4938-aa07-99988cc9d774_verboseLabel_en-US" xlink:label="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts Receivable</link:label>
    <link:label id="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock_label_en-US" xlink:label="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allowance For Doubtful Accounts [Policy Text Block]</link:label>
    <link:label id="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock_documentation_en-US" xlink:label="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allowance for doubtful accounts.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:to="lab_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_f285aa92-6318-428f-9246-b59884815b57_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:to="lab_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_afa538ff-99b3-47b3-92ff-42a703721500_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Issuance of common stock under employee stock compensation plans, net</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:to="lab_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CashPayable_14062ef9-e0cd-4f05-954e-ab2a8585f9db_terseLabel_en-US" xlink:label="lab_lgnd_CashPayable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash payable to Crystal Shareholders</link:label>
    <link:label id="lab_lgnd_CashPayable_label_en-US" xlink:label="lab_lgnd_CashPayable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Payable</link:label>
    <link:label id="lab_lgnd_CashPayable_documentation_en-US" xlink:label="lab_lgnd_CashPayable" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash Payable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPayable" xlink:href="lgnd-20181231.xsd#lgnd_CashPayable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CashPayable" xlink:to="lab_lgnd_CashPayable" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock_ea794d82-f565-4bd1-9b94-d68714563fb5_terseLabel_en-US" xlink:label="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Contingent Liabilities</link:label>
    <link:label id="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock_label_en-US" xlink:label="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Contingent Liabilities [Table Text Block]</link:label>
    <link:label id="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock_documentation_en-US" xlink:label="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Contingent Liabilities [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofContingentLiabilitiesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:to="lab_lgnd_ScheduleofContingentLiabilitiesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtDisclosureAbstract_label_en-US" xlink:label="lab_us-gaap_DebtDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Disclosure [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtDisclosureAbstract" xlink:to="lab_us-gaap_DebtDisclosureAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_d80d4124-90aa-4aec-98a0-c20210b7cc21_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities</link:label>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_4c5ad245-afd3-410c-bacd-a7f98f783b28_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Restricted Stock Activity</link:label>
    <link:label id="lab_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_0a859fd3-bf53-4a64-a128-dd3c1d9c8253_periodStartLabel_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial rights at beginning of period</link:label>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_24b43085-504a-48eb-a0fe-20efbf311c57_periodEndLabel_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commercial rights at end of period</link:label>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_label_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Acquisition Contingent Consideration Potential Cash Payment At End Of Period</link:label>
    <link:label id="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_documentation_en-US" xlink:label="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business acquisition contingent consideration, potential cash payment at end of period.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:to="lab_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_2fb91dd7-52ae-4270-bfa4-5dbe7da46781_terseLabel_en-US" xlink:label="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss recorded (as a percent)</link:label>
    <link:label id="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_label_en-US" xlink:label="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Qualitative or Quantitative Information, Loss Percentage Recorded</link:label>
    <link:label id="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_documentation_en-US" xlink:label="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity, Qualitative or Quantitative Information, Loss Percentage Recorded</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:href="lgnd-20181231.xsd#lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:to="lab_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConvertibleNotesPayableMember_5f1fc344-2819-49ad-94b3-8da146dfb3f4_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Notes</link:label>
    <link:label id="lab_us-gaap_ConvertibleNotesPayableMember_label_en-US" xlink:label="lab_us-gaap_ConvertibleNotesPayableMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Notes Payable [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleNotesPayableMember" xlink:to="lab_us-gaap_ConvertibleNotesPayableMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNi_8941d739-7f1a-4a4e-8a31-d79f2e28676f_terseLabel_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNi" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking</link:label>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNi_label_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNi" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Securities, FV-NI</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquitySecuritiesFvNi" xlink:to="lab_us-gaap_EquitySecuritiesFvNi" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_a9debf8c-3341-4f22-8c14-6c08d90e6fbd_negatedLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vested (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_e5e14af3-4e44-4448-9bc7-512eb3bc0ce7_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_d860879f-e13d-4326-baf6-56f80f03d71d_terseLabel_en-US" xlink:label="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Initial Application Period Cumulative Effect Transition [Domain]</link:label>
    <link:label id="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_label_en-US" xlink:label="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Initial Application Period Cumulative Effect Transition [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:to="lab_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_88626900-92db-4261-a2ad-f98c8d6a1465_terseLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss on settlement of Notes</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Loss on Settlement of Convertible Senior Notes</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Loss on Settlement of Convertible Senior Notes</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_ec3ef4ec-d1c6-4639-9bd4-e5929a7dc3a6_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Granted (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_a2e344cb-e942-45a6-8282-af9a0a3fcdcd_periodEndLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, cash equivalents, and restricted cash at end of year</link:label>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4706a78a-adba-47c5-a331-6c2fe14c9399_periodStartLabel_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, cash equivalents, and restricted cash at beginning of year</link:label>
    <link:label id="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_label_en-US" xlink:label="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="lab_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CrystalMember_466a1414-b84c-4b25-842a-b3d1cccb6d60_terseLabel_en-US" xlink:label="lab_lgnd_CrystalMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Crystal</link:label>
    <link:label id="lab_lgnd_CrystalMember_label_en-US" xlink:label="lab_lgnd_CrystalMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Crystal [Member]</link:label>
    <link:label id="lab_lgnd_CrystalMember_documentation_en-US" xlink:label="lab_lgnd_CrystalMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Crystal [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CrystalMember" xlink:to="lab_lgnd_CrystalMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_6fcac3f4-51f3-475d-9416-fc6a60ccbdf5_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted-average grant date fair value per share of stock options (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardNameDomain_00f9fde7-92af-41aa-b478-f1a39e252350_terseLabel_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credit Carryforward, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_TaxCreditCarryforwardNameDomain_label_en-US" xlink:label="lab_us-gaap_TaxCreditCarryforwardNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Tax Credit Carryforward, Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain" xlink:to="lab_us-gaap_TaxCreditCarryforwardNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentLineItems_1a018369-8ed1-4977-b046-1bfb219e9fb4_terseLabel_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment [Line Items]</link:label>
    <link:label id="lab_us-gaap_PropertyPlantAndEquipmentLineItems_label_en-US" xlink:label="lab_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Property, Plant and Equipment [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:to="lab_us-gaap_PropertyPlantAndEquipmentLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_87d36561-3308-4696-b6e6-d6322c2094cd_verboseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Remaining Contractual Term in Years</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_2a88b8e5-90b7-460a-bc1a-0360682d3cbd_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of trading days</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Threshold Trading Days</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdTradingDays" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensation_04f201be-dea5-47f7-b024-98d43088d259_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock-based compensation</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensation_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensation" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensation" xlink:to="lab_us-gaap_ShareBasedCompensation" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_1514f64e-63a3-4f23-9d59-49b2b9517c73_terseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments for New Accounting Pronouncements [Axis]</link:label>
    <link:label id="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_label_en-US" xlink:label="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments for New Accounting Pronouncements [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:to="lab_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_6a031f5e-45e5-4a70-bced-5d4fa04e6109_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Award expiration period</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AccruedStockRepurchases_41ce58d3-e2d5-48e3-a303-8b6c3b43fe3b_terseLabel_en-US" xlink:label="lab_lgnd_AccruedStockRepurchases" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments due to broker for share repurchase</link:label>
    <link:label id="lab_lgnd_AccruedStockRepurchases_label_en-US" xlink:label="lab_lgnd_AccruedStockRepurchases" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Stock Repurchases</link:label>
    <link:label id="lab_lgnd_AccruedStockRepurchases_documentation_en-US" xlink:label="lab_lgnd_AccruedStockRepurchases" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Stock Repurchases</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedStockRepurchases" xlink:href="lgnd-20181231.xsd#lgnd_AccruedStockRepurchases"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AccruedStockRepurchases" xlink:to="lab_lgnd_AccruedStockRepurchases" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_StatementGeographicalAxis_5ec063dd-cd72-4000-97e6-6625effb4d07_terseLabel_en-US" xlink:label="lab_srt_StatementGeographicalAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Geographical [Axis]</link:label>
    <link:label id="lab_srt_StatementGeographicalAxis_label_en-US" xlink:label="lab_srt_StatementGeographicalAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Geographical [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_StatementGeographicalAxis" xlink:to="lab_srt_StatementGeographicalAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_dcd2ef01-04f7-4e0f-921e-f988a9527c83_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective rate (as a percent)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Interest Rate, Effective Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:to="lab_us-gaap_DebtInstrumentInterestRateEffectivePercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_6ee3641f-31c4-4b0a-bbd8-597e23b4a61b_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts receivable, net</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInAccountsReceivable_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Accounts Receivable</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:to="lab_us-gaap_IncreaseDecreaseInAccountsReceivable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_b8f4e859-7d73-4414-b02b-d841817f1efc_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt conversion price per share (USD per share)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Conversion Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:to="lab_us-gaap_DebtInstrumentConvertibleConversionPrice1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredIncomeTaxLiabilities_5d1db935-98ae-43e8-9b58-2ecc3943fb11_negatedTotalLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilities" xlink:role="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net deferred tax liabilities</link:label>
    <link:label id="lab_us-gaap_DeferredIncomeTaxLiabilities_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxLiabilities" xlink:to="lab_us-gaap_DeferredIncomeTaxLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsValuationAllowance_a8be9bdd-599d-46d6-a918-f8d3442205ed_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Valuation allowance for deferred tax assets</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsValuationAllowance_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Valuation Allowance</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:to="lab_us-gaap_DeferredTaxAssetsValuationAllowance" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityVoluntaryFilers_c4202b05-3d74-42b2-812d-760f697f4664_terseLabel_en-US" xlink:label="lab_dei_EntityVoluntaryFilers" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:label id="lab_dei_EntityVoluntaryFilers_label_en-US" xlink:label="lab_dei_EntityVoluntaryFilers" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Voluntary Filers</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityVoluntaryFilers"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityVoluntaryFilers" xlink:to="lab_dei_EntityVoluntaryFilers" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityFilerCategory_61ed3384-6f65-41d3-8e15-648b9fa097de_terseLabel_en-US" xlink:label="lab_dei_EntityFilerCategory" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Filer Category</link:label>
    <link:label id="lab_dei_EntityFilerCategory_label_en-US" xlink:label="lab_dei_EntityFilerCategory" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Filer Category</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityFilerCategory"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityFilerCategory" xlink:to="lab_dei_EntityFilerCategory" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquityAbstract_label_en-US" xlink:label="lab_us-gaap_EquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityAbstract" xlink:to="lab_us-gaap_EquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_725d077d-6456-4eb3-8c77-96142c4b6e18_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred tax liabilities, net</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_8fc92fdd-08c8-4bd1-b0b7-290a970c42d0_terseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and Development Expenses</link:label>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpensePolicy_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and Development Expense, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpensePolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_1b3e119e-fd91-499e-814f-a93c849a9d13_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity component of currently redeemable convertible notes (Note 6)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_e360e353-0b5a-4673-be5c-81768f5153a5_verboseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Carrying value of equity component of convertible notes</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_17893629-cafa-49eb-91f4-839c8cc8fdd1_netLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:role="http://www.xbrl.org/2009/role/netLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Carrying value of equity component of 2023 Notes</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Carrying Amount of Equity Component</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:to="lab_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ResearchFacilityEmeryvilleCAMember_f18b8a1d-6458-4b25-a5fc-5618184aa3cc_terseLabel_en-US" xlink:label="lab_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Emeryville, CA</link:label>
    <link:label id="lab_lgnd_ResearchFacilityEmeryvilleCAMember_label_en-US" xlink:label="lab_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Emeryville, CA [Member]</link:label>
    <link:label id="lab_lgnd_ResearchFacilityEmeryvilleCAMember_documentation_en-US" xlink:label="lab_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research Facility - Emeryville, CA [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityEmeryvilleCAMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:to="lab_lgnd_ResearchFacilityEmeryvilleCAMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementLineItems_1b06ac0b-b180-4424-bc95-57d8b5e1a642_terseLabel_en-US" xlink:label="lab_us-gaap_StatementLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:label id="lab_us-gaap_StatementLineItems_label_en-US" xlink:label="lab_us-gaap_StatementLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementLineItems" xlink:to="lab_us-gaap_StatementLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_24f754ca-6600-4a3e-ba3d-d12b3c195777_terseLabel_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent liabilities - Metabasis</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_label_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Metabasis [Member]</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_documentation_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Metabasis</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:to="lab_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_9e53a37a-202e-4fcf-8889-174ef94c35eb_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FairValueByAssetClassAxis_label_en-US" xlink:label="lab_us-gaap_FairValueByAssetClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueByAssetClassAxis" xlink:to="lab_us-gaap_FairValueByAssetClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesAbstract_4b890f53-ebf6-4da2-8043-b432e1a15e0c_terseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities:</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAbstract_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAbstract" xlink:to="lab_us-gaap_LiabilitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock_48ce222f-2179-4f88-97ba-317b8b7db478_terseLabel_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation and Summary of Significant Accounting Policies</link:label>
    <link:label id="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock_label_en-US" xlink:label="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" xlink:to="lab_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GainLossOnSaleOfBusiness_fb3a14ae-09eb-4e7f-bcbc-3ea1773f8912_terseLabel_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfBusiness" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain on disposition of product line</link:label>
    <link:label id="lab_us-gaap_GainLossOnSaleOfBusiness_label_en-US" xlink:label="lab_us-gaap_GainLossOnSaleOfBusiness" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gain (Loss) on Disposition of Business</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GainLossOnSaleOfBusiness" xlink:to="lab_us-gaap_GainLossOnSaleOfBusiness" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_8a0287c8-1b1e-4316-af4d-b0884f6ba063_terseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average common shares outstanding:</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding Reconciliation [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:to="lab_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_AmendmentFlag_496e81a9-6794-47ac-b6d8-5af274d18f15_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:label id="lab_dei_AmendmentFlag_label_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_AmendmentFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag" xlink:to="lab_dei_AmendmentFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InvestmentIncomeNonoperating_7dc8d829-5725-4a20-af21-c8324295046a_terseLabel_en-US" xlink:label="lab_us-gaap_InvestmentIncomeNonoperating" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest income</link:label>
    <link:label id="lab_us-gaap_InvestmentIncomeNonoperating_label_en-US" xlink:label="lab_us-gaap_InvestmentIncomeNonoperating" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment Income, Nonoperating</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeNonoperating"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InvestmentIncomeNonoperating" xlink:to="lab_us-gaap_InvestmentIncomeNonoperating" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_144ab269-581c-4059-96e3-36a140c6582e_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred expense (benefit):</link:label>
    <link:label id="lab_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_label_en-US" xlink:label="lab_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:to="lab_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock_4e9e653f-a9c3-4ff2-91a3-827da603aa14_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Other Current Assets</link:label>
    <link:label id="lab_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Other Current Assets [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MilestonePaymentsAndRoyaltiesMember_400ec565-41f0-4f26-938f-589839e76bea_terseLabel_en-US" xlink:label="lab_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone Payments and Royalties</link:label>
    <link:label id="lab_lgnd_MilestonePaymentsAndRoyaltiesMember_label_en-US" xlink:label="lab_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone Payments and Royalties [Member]</link:label>
    <link:label id="lab_lgnd_MilestonePaymentsAndRoyaltiesMember_documentation_en-US" xlink:label="lab_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone Payments and Royalties</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:href="lgnd-20181231.xsd#lgnd_MilestonePaymentsAndRoyaltiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:to="lab_lgnd_MilestonePaymentsAndRoyaltiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OfficeEquipmentMember_30abe888-84aa-4281-b5ab-ef66601d2c78_verboseLabel_en-US" xlink:label="lab_us-gaap_OfficeEquipmentMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lab and office equipment</link:label>
    <link:label id="lab_us-gaap_OfficeEquipmentMember_label_en-US" xlink:label="lab_us-gaap_OfficeEquipmentMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office Equipment [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OfficeEquipmentMember" xlink:to="lab_us-gaap_OfficeEquipmentMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_85ce6e22-a19b-450e-98a5-d62fc77c0cba_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operations</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operations, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:to="lab_us-gaap_DiscontinuedOperationsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VestingAxis_d64eb0bc-cf45-43a8-9519-6d481eb82b8c_terseLabel_en-US" xlink:label="lab_us-gaap_VestingAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting [Axis]</link:label>
    <link:label id="lab_us-gaap_VestingAxis_label_en-US" xlink:label="lab_us-gaap_VestingAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VestingAxis" xlink:to="lab_us-gaap_VestingAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_e1d99ea7-33c7-4409-bbac-ca8807917ccc_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts receivable</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Receivables</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCentralIndexKey_97feedf9-b01b-4375-a7e7-03ea4ab0a056_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:label id="lab_dei_EntityCentralIndexKey_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey" xlink:to="lab_dei_EntityCentralIndexKey" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_9851b8a6-19e2-4578-9bd9-4c9c594e8349_terseLabel_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other</link:label>
    <link:label id="lab_us-gaap_OtherAccruedLiabilitiesCurrent_label_en-US" xlink:label="lab_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Accrued Liabilities, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:to="lab_us-gaap_OtherAccruedLiabilitiesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_97670537-6ac7-430a-97ef-b5e2f8e8ea74_terseLabel_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accumulated other comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember_label_en-US" xlink:label="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">AOCI Attributable to Parent [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:to="lab_us-gaap_AccumulatedOtherComprehensiveIncomeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_5d497a32-bbbf-4378-bd76-ccfb525747c2_terseLabel_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex-related revenue amount that triggers additional royalty payments</link:label>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_label_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Revenue Amount to Trigger Additional Royalty Payments</link:label>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_documentation_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Revenue Amount to Trigger Additional Royalty Payments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:to="lab_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_bd429eb2-e100-4b22-93d1-f318bb4469ae_totalLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, 1-2 years, net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in One and Two Years, Net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments, Due in One and Two Years, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_3f66792b-c246-419d-a6cf-00b8d3b04f3a_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, shares authorized (shares)</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesAuthorized_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesAuthorized" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares Authorized</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesAuthorized" xlink:to="lab_us-gaap_CommonStockSharesAuthorized" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_6237b715-7a03-4599-a3be-c49824464f6f_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued expenses</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:to="lab_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_082aaccd-6f80-4c1d-891d-bcee49b9f5bd_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Deferred Tax Assets and Liabilities</link:label>
    <link:label id="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Deferred Tax Assets and Liabilities [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_ProductsAndServicesDomain_05e3983e-a78f-4103-9815-cb5c87b0cfe6_terseLabel_en-US" xlink:label="lab_srt_ProductsAndServicesDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Domain]</link:label>
    <link:label id="lab_srt_ProductsAndServicesDomain_label_en-US" xlink:label="lab_srt_ProductsAndServicesDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_ProductsAndServicesDomain" xlink:to="lab_srt_ProductsAndServicesDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OwnershipInEntityByDirectorPercentage_b0de2b3e-e2b6-4306-8cbd-e13b350d51ca_terseLabel_en-US" xlink:label="lab_lgnd_OwnershipInEntityByDirectorPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership in entity by director (as a percent)</link:label>
    <link:label id="lab_lgnd_OwnershipInEntityByDirectorPercentage_label_en-US" xlink:label="lab_lgnd_OwnershipInEntityByDirectorPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership in Entity by Director, Percentage</link:label>
    <link:label id="lab_lgnd_OwnershipInEntityByDirectorPercentage_documentation_en-US" xlink:label="lab_lgnd_OwnershipInEntityByDirectorPercentage" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership in Entity by Director, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OwnershipInEntityByDirectorPercentage" xlink:href="lgnd-20181231.xsd#lgnd_OwnershipInEntityByDirectorPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OwnershipInEntityByDirectorPercentage" xlink:to="lab_lgnd_OwnershipInEntityByDirectorPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TypeOfAdoptionMember_6b4c47bc-6a02-424e-a4bb-d941ad4a5dd2_terseLabel_en-US" xlink:label="lab_us-gaap_TypeOfAdoptionMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Type of Adoption [Domain]</link:label>
    <link:label id="lab_us-gaap_TypeOfAdoptionMember_label_en-US" xlink:label="lab_us-gaap_TypeOfAdoptionMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Type of Adoption [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TypeOfAdoptionMember" xlink:to="lab_us-gaap_TypeOfAdoptionMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_a7f07d8c-17ef-4ef3-be09-74a5b226470d_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Reductions for tax positions of prior years</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:to="lab_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeTwoMember_4994833f-3393-4a17-b6a0-9e3d6096f889_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTwoMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$10.12 - $12.81</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeTwoMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTwoMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Two [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeTwoMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeTwoMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Two [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTwoMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTwoMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeTwoMember" xlink:to="lab_lgnd_ExercisePriceRangeTwoMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueDisclosuresAbstract_label_en-US" xlink:label="lab_us-gaap_FairValueDisclosuresAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Disclosures [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract" xlink:to="lab_us-gaap_FairValueDisclosuresAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityShellCompany_6eec8cac-7821-476c-80a5-85bfb1edc517_terseLabel_en-US" xlink:label="lab_dei_EntityShellCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Shell Company</link:label>
    <link:label id="lab_dei_EntityShellCompany_label_en-US" xlink:label="lab_dei_EntityShellCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Shell Company</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityShellCompany"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityShellCompany" xlink:to="lab_dei_EntityShellCompany" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_43482946-76c0-4801-a6ce-c5603618bfe8_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-Based Compensation</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:to="lab_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_MeasurementInputExpectedDividendRateMember_0e20e46b-8614-427b-aadf-f0292c3e10eb_terseLabel_en-US" xlink:label="lab_us-gaap_MeasurementInputExpectedDividendRateMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dividend yield</link:label>
    <link:label id="lab_us-gaap_MeasurementInputExpectedDividendRateMember_label_en-US" xlink:label="lab_us-gaap_MeasurementInputExpectedDividendRateMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement Input, Expected Dividend Rate [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_MeasurementInputExpectedDividendRateMember" xlink:to="lab_us-gaap_MeasurementInputExpectedDividendRateMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquireShortTermInvestments_9d023fe7-2cc9-4a8e-b398-c34b727b2050_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireShortTermInvestments" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Purchases of short-term investments</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireShortTermInvestments_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireShortTermInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Short-term Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireShortTermInvestments" xlink:to="lab_us-gaap_PaymentsToAcquireShortTermInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockholdersEquity_bcf41725-b90c-427a-a335-a675de111bbe_totalLabel_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total stockholders&#8217; equity</link:label>
    <link:label id="lab_us-gaap_StockholdersEquity_label_en-US" xlink:label="lab_us-gaap_StockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stockholders' Equity Attributable to Parent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockholdersEquity" xlink:to="lab_us-gaap_StockholdersEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PlanNameAxis_1c47d015-4ef9-4438-8b57-e14866cb0759_terseLabel_en-US" xlink:label="lab_us-gaap_PlanNameAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Axis]</link:label>
    <link:label id="lab_us-gaap_PlanNameAxis_label_en-US" xlink:label="lab_us-gaap_PlanNameAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Plan Name [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PlanNameAxis" xlink:to="lab_us-gaap_PlanNameAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_3fb4544c-9908-440b-b582-d0d90f2bd061_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntityDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entity Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:to="lab_us-gaap_VariableInterestEntityDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquityComponentDomain_20331d7e-c2f5-4e78-9ac9-eceb7a373d45_terseLabel_en-US" xlink:label="lab_us-gaap_EquityComponentDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total stockholders&#8217; equity</link:label>
    <link:label id="lab_us-gaap_EquityComponentDomain_6489f36f-ea5b-4aa9-8380-d41e5557bb6a_verboseLabel_en-US" xlink:label="lab_us-gaap_EquityComponentDomain" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Component [Domain]</link:label>
    <link:label id="lab_us-gaap_EquityComponentDomain_label_en-US" xlink:label="lab_us-gaap_EquityComponentDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Component [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityComponentDomain" xlink:to="lab_us-gaap_EquityComponentDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_42119d68-22c4-4cd6-91cf-cb101ac798e1_terseLabel_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill, Intangible Assets and Other Long-Lived Assets</link:label>
    <link:label id="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_label_en-US" xlink:label="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:to="lab_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AmendedESPPMember_74bdd270-4cde-45af-8ddf-e397d88c1955_terseLabel_en-US" xlink:label="lab_lgnd_AmendedESPPMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amended ESPP</link:label>
    <link:label id="lab_lgnd_AmendedESPPMember_label_en-US" xlink:label="lab_lgnd_AmendedESPPMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amended ESPP [Member]</link:label>
    <link:label id="lab_lgnd_AmendedESPPMember_documentation_en-US" xlink:label="lab_lgnd_AmendedESPPMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amended ESPP [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AmendedESPPMember" xlink:href="lgnd-20181231.xsd#lgnd_AmendedESPPMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AmendedESPPMember" xlink:to="lab_lgnd_AmendedESPPMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_fa01eda0-65a4-421c-9e0e-cb453cf299c8_terseLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deduction to additional paid-in-capital for warrants settled</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrants Settled</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrants Settled</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockMember_ee378653-0924-46e4-809d-ddd016e0ab47_terseLabel_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock</link:label>
    <link:label id="lab_us-gaap_CommonStockMember_label_en-US" xlink:label="lab_us-gaap_CommonStockMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockMember" xlink:to="lab_us-gaap_CommonStockMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_ffa7bb38-ed41-42c5-ab77-27d9680ba1b8_terseLabel_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $1.5 million with Four Collaboration Agreements</link:label>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_label_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $1.5 million with Four Collaboration Agreements [Member]</link:label>
    <link:label id="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_documentation_en-US" xlink:label="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold of Revenues above $1.5 million with Four Collaboration Agreements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:to="lab_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_d8310de6-c850-4f36-b05b-ad5c0d0693ac_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest on debt instrument (as a percent)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Interest Rate, Stated Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:to="lab_us-gaap_DebtInstrumentInterestRateStatedPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_c086f7a6-b68b-4800-b907-57e9fc98f28b_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock-based compensation</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:to="lab_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_7202eecd-6cc9-46f1-8364-6cadd565f71d_negatedLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrant repurchase</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrants Repurchased</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, Warrants Repurchased</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_f337e10b-6cb4-4fe4-a704-802ad1d97832_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercisable at end of period (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccountsPayableCurrent_190b1ea6-c39f-4fc5-8bd8-8c04f388d102_verboseLabel_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts payable</link:label>
    <link:label id="lab_us-gaap_AccountsPayableCurrent_label_en-US" xlink:label="lab_us-gaap_AccountsPayableCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounts Payable, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountsPayableCurrent" xlink:to="lab_us-gaap_AccountsPayableCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NotesPayableCurrent_570145c0-a596-4ff1-970f-331af414fa40_terseLabel_en-US" xlink:label="lab_us-gaap_NotesPayableCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total current portion of notes payable</link:label>
    <link:label id="lab_us-gaap_NotesPayableCurrent_label_en-US" xlink:label="lab_us-gaap_NotesPayableCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes Payable, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesPayableCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesPayableCurrent" xlink:to="lab_us-gaap_NotesPayableCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LicenseFeesMilestonesandProductOtherMember_4152d3bd-d769-4c0f-89a4-4b9119f01d93_terseLabel_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License fees, milestones and other revenues</link:label>
    <link:label id="lab_lgnd_LicenseFeesMilestonesandProductOtherMember_label_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees, Milestones, and Product, Other [Member]</link:label>
    <link:label id="lab_lgnd_LicenseFeesMilestonesandProductOtherMember_documentation_en-US" xlink:label="lab_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees, Milestones, and Product, Other [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesandProductOtherMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:to="lab_lgnd_LicenseFeesMilestonesandProductOtherMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_0f2c388d-559b-4bbe-a2d3-8ac76b944ddd_terseLabel_en-US" xlink:label="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares received pursuant to MLA amendment (shares)</link:label>
    <link:label id="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_label_en-US" xlink:label="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investment, Shares Received, Licensing Agreement</link:label>
    <link:label id="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_documentation_en-US" xlink:label="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investment, Shares Received, Licensing Agreement</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:href="lgnd-20181231.xsd#lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:to="lab_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_CurrentFiscalYearEndDate_ab94a3c1-83c7-4358-8401-f7cdee1739fc_terseLabel_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:label id="lab_dei_CurrentFiscalYearEndDate_label_en-US" xlink:label="lab_dei_CurrentFiscalYearEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Fiscal Year End Date</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CurrentFiscalYearEndDate" xlink:to="lab_dei_CurrentFiscalYearEndDate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_9275e2e1-4e78-46c5-ad2a-7797ecdff000_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intrinsic value of options exercised</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxAuthorityDomain_545ad3ec-1e64-463e-96cd-c7d0a8d90698_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Authority [Domain]</link:label>
    <link:label id="lab_us-gaap_IncomeTaxAuthorityDomain_label_en-US" xlink:label="lab_us-gaap_IncomeTaxAuthorityDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Authority [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain" xlink:to="lab_us-gaap_IncomeTaxAuthorityDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_6783259d-0a6d-4f80-90c9-9440fcdac003_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Inputs and Assumptions Used to Calculate Fair Value of Derivatives</link:label>
    <link:label id="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Derivative Instruments [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:to="lab_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_c8166062-c2f0-42b2-9d8f-e8dbedcbdd6a_verboseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued operations:</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract" xlink:to="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_1b6c08ba-41e1-4912-9661-cb40a15cbca6_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of consecutive trading days</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Threshold Consecutive Trading Days</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_818a9ff7-f511-47da-b21a-4e0315890b25_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Granted (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeFourMember_d7b63efa-c9f8-42fe-973e-a22d7c6d360d_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFourMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$16.14 - $17.88</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeFourMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFourMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Four [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeFourMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeFourMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Four [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFourMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFourMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeFourMember" xlink:to="lab_lgnd_ExercisePriceRangeFourMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_f5519805-e832-4523-a57d-7858dee3e332_negatedTerseLabel_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Identified intangibles</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_label_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Finite-Lived Intangible Assets</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_documentation_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Finite-Lived Intangible Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:to="lab_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InventoryPolicyTextBlock_dfc8a79f-384d-4f0b-bde1-d7d2ae99ed9d_verboseLabel_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory</link:label>
    <link:label id="lab_us-gaap_InventoryPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_InventoryPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InventoryPolicyTextBlock" xlink:to="lab_us-gaap_InventoryPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ImpairmentOfInvestments_dac9e66b-5520-4aa3-bc73-e692d55fcd96_terseLabel_en-US" xlink:label="lab_us-gaap_ImpairmentOfInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other than temporary impairment of investment in Viking</link:label>
    <link:label id="lab_us-gaap_ImpairmentOfInvestments_label_en-US" xlink:label="lab_us-gaap_ImpairmentOfInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other than Temporary Impairment Losses, Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ImpairmentOfInvestments" xlink:to="lab_us-gaap_ImpairmentOfInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_b95d1f81-bddf-4b76-993b-bebfc0642cb3_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Granted (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CorporateHeadquartersSanDiegoCAMember_b1cc1f3a-17c4-420a-9e65-354ea6145cd3_terseLabel_en-US" xlink:label="lab_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate headquarters-San Diego, CA</link:label>
    <link:label id="lab_lgnd_CorporateHeadquartersSanDiegoCAMember_label_en-US" xlink:label="lab_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Headquarters - San Diego, CA [Member]</link:label>
    <link:label id="lab_lgnd_CorporateHeadquartersSanDiegoCAMember_documentation_en-US" xlink:label="lab_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Headquarters - San Diego, CA [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:href="lgnd-20181231.xsd#lgnd_CorporateHeadquartersSanDiegoCAMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:to="lab_lgnd_CorporateHeadquartersSanDiegoCAMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_1c76ca28-5141-47b5-99de-5ac9e92a6fdf_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Effective Income Tax Rate Reconciliation</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_406b77e3-5c9f-42f6-b5e9-f06d64e06ad9_verboseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-lived intangible asset, useful life</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Asset, Useful Life</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetUsefulLife" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_83e1ceb3-c75a-4496-8a00-cd5eb563a66f_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Foreign</link:label>
    <link:label id="lab_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Foreign Income Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:to="lab_us-gaap_DeferredForeignIncomeTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_504e6451-1771-48bd-b1d0-6dd7bf7af0c8_verboseLabel_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of contingent consideration</link:label>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_label_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration</link:label>
    <link:label id="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_documentation_en-US" xlink:label="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:to="lab_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_4012ed5f-4325-4e90-abe5-6e5d6184c969_terseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Capital Loss Carryforward</link:label>
    <link:label id="lab_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_label_en-US" xlink:label="lab_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Assets, Capital Loss Carryforwards</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsCapitalLossCarryforwards"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards" xlink:to="lab_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember_4c70007a-d999-4c3c-878d-55675b32cc92_terseLabel_en-US" xlink:label="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office and research facility-La Jolla, CA</link:label>
    <link:label id="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember_label_en-US" xlink:label="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office and Research Facility - La Jolla, CA [Member]</link:label>
    <link:label id="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember_documentation_en-US" xlink:label="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Office and Research Facility - La Jolla, CA [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:href="lgnd-20181231.xsd#lgnd_OfficeandResearchFacilityLaJollaCAMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:to="lab_lgnd_OfficeandResearchFacilityLaJollaCAMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_f9b54629-953b-4587-bea2-8c1e398e13f4_negatedLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Forfeited (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_7768f3f9-e2ed-4d57-a999-61d8f8dcbecc_totalLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash (used in) provided by financing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_d199e784-2338-4b86-b297-a20596e7a385_terseLabel_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net cash provided by financing activities</link:label>
    <link:label id="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities_label_en-US" xlink:label="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Cash Provided by (Used in) Financing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:to="lab_us-gaap_NetCashProvidedByUsedInFinancingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_362ef74a-d916-44c0-9165-56b985d100bb_terseLabel_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based compensation expense</link:label>
    <link:label id="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_label_en-US" xlink:label="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Allocated Share-based Compensation Expense, Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:to="lab_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_e73e5294-4972-4550-86fd-14514e5eb5fc_terseLabel_en-US" xlink:label="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in derivative asset and liability fair value</link:label>
    <link:label id="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_label_en-US" xlink:label="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in Derivative Asset and Liability Fair Value</link:label>
    <link:label id="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_documentation_en-US" xlink:label="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in Derivative Asset and Liability Fair Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:href="lgnd-20181231.xsd#lgnd_ChangeInDerivativeAssetAndLiabilityFairValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:to="lab_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_d859d114-8c81-4484-b6c5-3122f358f717_verboseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Recurring</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementsRecurringMember_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementsRecurringMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurements, Recurring [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementsRecurringMember" xlink:to="lab_us-gaap_FairValueMeasurementsRecurringMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_1947fed1-cc37-42f5-a2b0-bb4c1c786b3b_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aggregate ownership (as a percent)</link:label>
    <link:label id="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investment, Ownership Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:to="lab_us-gaap_EquityMethodInvestmentOwnershipPercentage" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LeaseholdImprovementsMember_ea6e6895-8e89-40f4-bda4-3affe7234e9c_verboseLabel_en-US" xlink:label="lab_us-gaap_LeaseholdImprovementsMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leasehold improvements</link:label>
    <link:label id="lab_us-gaap_LeaseholdImprovementsMember_label_en-US" xlink:label="lab_us-gaap_LeaseholdImprovementsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leasehold Improvements [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeaseholdImprovementsMember" xlink:to="lab_us-gaap_LeaseholdImprovementsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_6364cf84-b282-4f2c-a081-3133acef1e0d_negatedTerseLabel_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Retrophin fair value adjustment</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_label_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Fair Value Adjustment</link:label>
    <link:label id="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_documentation_en-US" xlink:label="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Fair Value Adjustment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFairValueAdjustment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:to="lab_lgnd_DeferredTaxLiabilitiesFairValueAdjustment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_a75b7cb4-bc30-41db-8eec-eaf6b4987f62_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock price trigger to classify convertible debt as current (as a percent)</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:to="lab_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commitments and Contingencies Disclosure [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:to="lab_us-gaap_CommitmentsAndContingenciesDisclosureAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_d10418c9-999b-4388-afff-5efe67cddbb4_verboseLabel_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted-average period in which cost is expected to be recognized</link:label>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_label_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:to="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInInventories_9c2e9c17-a340-4833-b7a2-1bc9fc6b4acc_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Inventory</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInInventories_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInInventories" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Inventories</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInInventories" xlink:to="lab_us-gaap_IncreaseDecreaseInInventories" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_35fd1749-65a2-4c0a-8ecd-1cb64086ac9b_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Business Acquisitions, by Acquisition [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Business Acquisitions, by Acquisition [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:to="lab_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_6da86800-907c-4f0e-a4ee-9dce999349f8_negatedTerseLabel_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in fair value of the convertible debt receivable from Viking and warrants</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_label_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Fair Value of Convertible Debt Receivable and Warrant</link:label>
    <link:label id="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_documentation_en-US" xlink:label="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Fair Value of Convertible Debt Receivable and Warrant</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:to="lab_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentLineItems_20871cf6-00ca-4f90-90b3-dab77cd8582f_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument [Line Items]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentLineItems_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentLineItems" xlink:to="lab_us-gaap_DebtInstrumentLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SubsequentEventMember_e2695dca-b040-4729-8b26-609d7eb17317_terseLabel_en-US" xlink:label="lab_us-gaap_SubsequentEventMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event</link:label>
    <link:label id="lab_us-gaap_SubsequentEventMember_label_en-US" xlink:label="lab_us-gaap_SubsequentEventMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Subsequent Event [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SubsequentEventMember" xlink:to="lab_us-gaap_SubsequentEventMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WarrantMember_29cdab82-1dde-4902-b566-4dea736ab97d_verboseLabel_en-US" xlink:label="lab_us-gaap_WarrantMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrants</link:label>
    <link:label id="lab_us-gaap_WarrantMember_70556fd9-ae2b-4a5f-9db9-a3c49c275d38_terseLabel_en-US" xlink:label="lab_us-gaap_WarrantMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in warrants</link:label>
    <link:label id="lab_us-gaap_WarrantMember_label_en-US" xlink:label="lab_us-gaap_WarrantMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrant [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WarrantMember" xlink:to="lab_us-gaap_WarrantMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_df2d3e04-7a70-4d6a-8cf5-52358f0e7ed8_verboseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options vested and expected to vest, Weighted Average Remaining Contractual Term in Years</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:to="lab_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_ee085af6-143f-4018-a627-ce193bc25535_terseLabel_en-US" xlink:label="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Compensation</link:label>
    <link:label id="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent_label_en-US" xlink:label="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee-related Liabilities, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:to="lab_us-gaap_EmployeeRelatedLiabilitiesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_ca6ee3cb-2e03-4d3b-840e-e1e5ec81a474_terseLabel_en-US" xlink:label="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity period of cash and cash equivalents, maximum</link:label>
    <link:label id="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_label_en-US" xlink:label="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity Period Of Highly Liquid Securities Maximum</link:label>
    <link:label id="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_documentation_en-US" xlink:label="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maturity period of highly liquid securities maximum.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:href="lgnd-20181231.xsd#lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:to="lab_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_908ab047-366c-4bec-a689-6720a507fb71_terseLabel_en-US" xlink:label="lab_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name of Property [Axis]</link:label>
    <link:label id="lab_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_label_en-US" xlink:label="lab_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Name of Property [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:to="lab_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_b73183c8-ee02-4fe8-96e7-cc0f58afd0e2_verboseLabel_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, fair value</link:label>
    <link:label id="lab_us-gaap_AssetsFairValueDisclosure_label_en-US" xlink:label="lab_us-gaap_AssetsFairValueDisclosure" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Fair Value Disclosure</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsFairValueDisclosure" xlink:to="lab_us-gaap_AssetsFairValueDisclosure" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_f6622f6c-5cef-4b18-9051-e4aa117e27ef_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense, 2023</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Year Five</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommitmentsAndContingencies_8f3cf61d-72b7-45d0-9d3b-2a25be45a216_verboseLabel_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingencies" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commitments and contingencies</link:label>
    <link:label id="lab_us-gaap_CommitmentsAndContingencies_label_en-US" xlink:label="lab_us-gaap_CommitmentsAndContingencies" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commitments and Contingencies</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommitmentsAndContingencies" xlink:to="lab_us-gaap_CommitmentsAndContingencies" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfStockholdersEquityAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfStockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Stockholders' Equity [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract" xlink:to="lab_us-gaap_StatementOfStockholdersEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConvertibleDebtCurrent_9a428fcf-54af-4d58-958f-362874600c56_terseLabel_en-US" xlink:label="lab_us-gaap_ConvertibleDebtCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2019 convertible senior notes, net</link:label>
    <link:label id="lab_us-gaap_ConvertibleDebtCurrent_label_en-US" xlink:label="lab_us-gaap_ConvertibleDebtCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Debt, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConvertibleDebtCurrent" xlink:to="lab_us-gaap_ConvertibleDebtCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CurrentFederalTaxExpenseBenefit_f59fb72b-c779-4dab-b752-66e06596c0ae_terseLabel_en-US" xlink:label="lab_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Federal</link:label>
    <link:label id="lab_us-gaap_CurrentFederalTaxExpenseBenefit_label_en-US" xlink:label="lab_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Federal Tax Expense (Benefit)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:to="lab_us-gaap_CurrentFederalTaxExpenseBenefit" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_1f566aa3-0bb5-4346-9cb6-3b2fe9217926_totalLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, net, Total</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_951e3692-1736-4da7-b197-a994ec4220ec_verboseLabel_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and development</link:label>
    <link:label id="lab_us-gaap_ResearchAndDevelopmentExpense_label_en-US" xlink:label="lab_us-gaap_ResearchAndDevelopmentExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and Development Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ResearchAndDevelopmentExpense" xlink:to="lab_us-gaap_ResearchAndDevelopmentExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_Phase3ClinicalTrialMember_6ff8ba9e-d96c-482c-8e9f-c007ffd9af4d_terseLabel_en-US" xlink:label="lab_lgnd_Phase3ClinicalTrialMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Phase 3 Clinical Trial</link:label>
    <link:label id="lab_lgnd_Phase3ClinicalTrialMember_label_en-US" xlink:label="lab_lgnd_Phase3ClinicalTrialMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Phase 3 Clinical Trial [Member]</link:label>
    <link:label id="lab_lgnd_Phase3ClinicalTrialMember_documentation_en-US" xlink:label="lab_lgnd_Phase3ClinicalTrialMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Phase 3 Clinical Trial</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_Phase3ClinicalTrialMember" xlink:href="lgnd-20181231.xsd#lgnd_Phase3ClinicalTrialMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_Phase3ClinicalTrialMember" xlink:to="lab_lgnd_Phase3ClinicalTrialMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLossCarryforwardsLineItems_35966091-381c-437f-8fe9-b69f95c29877_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwardsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Loss Carryforwards [Line Items]</link:label>
    <link:label id="lab_us-gaap_OperatingLossCarryforwardsLineItems_label_en-US" xlink:label="lab_us-gaap_OperatingLossCarryforwardsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Loss Carryforwards [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems" xlink:to="lab_us-gaap_OperatingLossCarryforwardsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_ac177ee8-a986-4de2-ab71-2be4b705ba59_terseLabel_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">U.S. Government bonds</link:label>
    <link:label id="lab_us-gaap_USTreasurySecuritiesMember_label_en-US" xlink:label="lab_us-gaap_USTreasurySecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">US Treasury Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_USTreasurySecuritiesMember" xlink:to="lab_us-gaap_USTreasurySecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_VestingPeriodTwoMember_53faf313-65a0-46e3-a4e0-77abb64e2518_terseLabel_en-US" xlink:label="lab_lgnd_VestingPeriodTwoMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vest 1/48 each month for forty-two months</link:label>
    <link:label id="lab_lgnd_VestingPeriodTwoMember_label_en-US" xlink:label="lab_lgnd_VestingPeriodTwoMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting Period Two [Member]</link:label>
    <link:label id="lab_lgnd_VestingPeriodTwoMember_documentation_en-US" xlink:label="lab_lgnd_VestingPeriodTwoMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Vesting Period Two [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodTwoMember" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodTwoMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_VestingPeriodTwoMember" xlink:to="lab_lgnd_VestingPeriodTwoMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_bf299160-9264-4598-8558-2b44451c352d_terseLabel_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex-related revenue amount that triggers royalty payments</link:label>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_label_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Revenue Amount to Trigger Royalty Payments</link:label>
    <link:label id="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_documentation_en-US" xlink:label="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Threshold Revenue Amount to Trigger Royalty Payments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:to="lab_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationTaxCreditsOther_a6092d39-0550-48ad-9d1d-8cde6729efae_negatedLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationTaxCreditsOther" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Expired NOLs and credits</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationTaxCreditsOther_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationTaxCreditsOther" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsOther"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther" xlink:to="lab_us-gaap_IncomeTaxReconciliationTaxCreditsOther" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentPeriodEndDate_a343a251-3866-4919-bfcc-13b189804a9c_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Period End Date</link:label>
    <link:label id="lab_dei_DocumentPeriodEndDate_label_en-US" xlink:label="lab_dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Period End Date</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentPeriodEndDate" xlink:to="lab_dei_DocumentPeriodEndDate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingLeasedAssetsLineItems_8c0be524-d77f-4bc2-9719-3d9202dc2738_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingLeasedAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leased Assets [Line Items]</link:label>
    <link:label id="lab_us-gaap_OperatingLeasedAssetsLineItems_label_en-US" xlink:label="lab_us-gaap_OperatingLeasedAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leased Assets [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems" xlink:to="lab_us-gaap_OperatingLeasedAssetsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_991d4c5e-cddc-4927-ad2d-0f6acb66d7bb_terseLabel_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effect of exchange rate changes on cash</link:label>
    <link:label id="lab_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_label_en-US" xlink:label="lab_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:to="lab_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_683ab166-ef96-4945-b415-b1707294017e_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash and cash equivalents</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock_e30ed7eb-ccad-43c5-8021-b6b3d10275a4_terseLabel_en-US" xlink:label="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preclinical Study and Clinical Trial Accruals</link:label>
    <link:label id="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock_label_en-US" xlink:label="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preclinical Study and Clinical Trial Accruals [Policy Text Block]</link:label>
    <link:label id="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock_documentation_en-US" xlink:label="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Preclinical Study and Clinical Trial Accruals [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:href="lgnd-20181231.xsd#lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:to="lab_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_b5f881ac-f7fe-4a36-b017-6c0d5c380da7_terseLabel_en-US" xlink:label="lab_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cumulative-effect adjustment from adoption of ASU</link:label>
    <link:label id="lab_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_label_en-US" xlink:label="lab_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cumulative Effect of New Accounting Principle in Period of Adoption</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:to="lab_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NotesAndLoansReceivableGrossCurrent_ed34d575-b97a-4215-bd64-c417e0fbcbd8_terseLabel_en-US" xlink:label="lab_us-gaap_NotesAndLoansReceivableGrossCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Note receivable from Viking</link:label>
    <link:label id="lab_us-gaap_NotesAndLoansReceivableGrossCurrent_label_en-US" xlink:label="lab_us-gaap_NotesAndLoansReceivableGrossCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes, Loans and Financing Receivable, Gross, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesAndLoansReceivableGrossCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesAndLoansReceivableGrossCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NotesAndLoansReceivableGrossCurrent" xlink:to="lab_us-gaap_NotesAndLoansReceivableGrossCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfWarrants_56c8387e-f72f-46f4-b394-69babb34429e_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfWarrants" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from issuance of warrants</link:label>
    <link:label id="lab_us-gaap_ProceedsFromIssuanceOfWarrants_label_en-US" xlink:label="lab_us-gaap_ProceedsFromIssuanceOfWarrants" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Issuance of Warrants</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromIssuanceOfWarrants" xlink:to="lab_us-gaap_ProceedsFromIssuanceOfWarrants" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockValue_03eb9422-af67-4785-bf9c-68a54a192188_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockValue" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, $0.001 par value; 60,000,000 and 33,333,333 shares authorized; 20,765,533 and 21,148,665 shares issued and outstanding at December&#160;31, 2018 and 2017, respectively</link:label>
    <link:label id="lab_us-gaap_CommonStockValue_label_en-US" xlink:label="lab_us-gaap_CommonStockValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Value, Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockValue" xlink:to="lab_us-gaap_CommonStockValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_b639ab6e-1244-4894-bf23-1d1f86ab6fd4_terseLabel_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive Income (Loss)</link:label>
    <link:label id="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Comprehensive Income, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:to="lab_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LongTermNotesPayable_29a340ad-9ce4-41da-b5ad-b7fa13616f79_terseLabel_en-US" xlink:label="lab_us-gaap_LongTermNotesPayable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total long-term portion of notes payable</link:label>
    <link:label id="lab_us-gaap_LongTermNotesPayable_label_en-US" xlink:label="lab_us-gaap_LongTermNotesPayable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Notes Payable, Noncurrent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermNotesPayable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermNotesPayable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LongTermNotesPayable" xlink:to="lab_us-gaap_LongTermNotesPayable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_9e8ffeed-049d-4355-9ae2-24406a9588bb_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentNameDomain_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentNameDomain" xlink:to="lab_us-gaap_DebtInstrumentNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_537d768d-68b5-4cec-88b7-cd3e3a2f6da3_terseLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares issued in OMT acquisition</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_a8428182-87eb-48f2-86b4-3affde10f970_negatedLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock issued for acquisition, net of issuance cost</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Issued During Period, Value, Acquisitions</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:to="lab_us-gaap_StockIssuedDuringPeriodValueAcquisitions" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_e6595645-f54c-44c7-aa39-ea38994a803b_terseLabel_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Presentation</link:label>
    <link:label id="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Basis of Accounting, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:to="lab_us-gaap_BasisOfAccountingPolicyPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfWarrants_dd002e84-0f08-42ec-9e9c-2327e8926957_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase of warrants</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfWarrants_2f68383a-412f-4203-ac82-4eb844a6bbaf_terseLabel_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for repurchase of warrants</link:label>
    <link:label id="lab_us-gaap_PaymentsForRepurchaseOfWarrants_label_en-US" xlink:label="lab_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Repurchase of Warrants</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:to="lab_us-gaap_PaymentsForRepurchaseOfWarrants" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CostOfGoodsAndServicesSold_e899c409-d66c-4e61-8375-46e4c230cc3e_terseLabel_en-US" xlink:label="lab_us-gaap_CostOfGoodsAndServicesSold" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of material sales</link:label>
    <link:label id="lab_us-gaap_CostOfGoodsAndServicesSold_label_en-US" xlink:label="lab_us-gaap_CostOfGoodsAndServicesSold" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cost of Goods and Services Sold</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CostOfGoodsAndServicesSold" xlink:to="lab_us-gaap_CostOfGoodsAndServicesSold" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_NumberofCollaborationAgreements_c0e42296-a731-4b69-98f0-d7f29ed88576_terseLabel_en-US" xlink:label="lab_lgnd_NumberofCollaborationAgreements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of collaboration agreements</link:label>
    <link:label id="lab_lgnd_NumberofCollaborationAgreements_label_en-US" xlink:label="lab_lgnd_NumberofCollaborationAgreements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of Collaboration Agreements</link:label>
    <link:label id="lab_lgnd_NumberofCollaborationAgreements_documentation_en-US" xlink:label="lab_lgnd_NumberofCollaborationAgreements" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Number of Collaboration Agreements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberofCollaborationAgreements" xlink:href="lgnd-20181231.xsd#lgnd_NumberofCollaborationAgreements"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_NumberofCollaborationAgreements" xlink:to="lab_lgnd_NumberofCollaborationAgreements" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_569bd17f-72e5-4f39-80bf-83d1c4119046_terseLabel_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Loss on repurchase of warrants</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_label_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, (Gain) Loss on Repurchase of Warrants</link:label>
    <link:label id="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_documentation_en-US" xlink:label="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Additional Paid in Capital, (Gain) Loss on Repurchase of Warrants</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:to="lab_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_SelexisMember_70d2167f-971b-4f33-9ce8-6f3608f9af1f_terseLabel_en-US" xlink:label="lab_lgnd_SelexisMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Selexis</link:label>
    <link:label id="lab_lgnd_SelexisMember_label_en-US" xlink:label="lab_lgnd_SelexisMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Selexis [Member]</link:label>
    <link:label id="lab_lgnd_SelexisMember_documentation_en-US" xlink:label="lab_lgnd_SelexisMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Selexis [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_SelexisMember" xlink:href="lgnd-20181231.xsd#lgnd_SelexisMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_SelexisMember" xlink:to="lab_lgnd_SelexisMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProfitLoss_6516e29e-472e-4fde-8e0e-01417ad1864b_totalLabel_en-US" xlink:label="lab_us-gaap_ProfitLoss" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net income (loss)</link:label>
    <link:label id="lab_us-gaap_ProfitLoss_label_en-US" xlink:label="lab_us-gaap_ProfitLoss" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net Income (Loss), Including Portion Attributable to Noncontrolling Interest</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProfitLoss" xlink:to="lab_us-gaap_ProfitLoss" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_70b997d8-9b4a-43ff-8c3b-5085c8664746_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Redemption Period Two</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Redemption, Period Two [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:to="lab_us-gaap_DebtInstrumentRedemptionPeriodTwoMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TransferredOverTimeMember_714156b7-fec6-4294-ba7d-70fc02c890b5_terseLabel_en-US" xlink:label="lab_us-gaap_TransferredOverTimeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Transferred over Time</link:label>
    <link:label id="lab_us-gaap_TransferredOverTimeMember_label_en-US" xlink:label="lab_us-gaap_TransferredOverTimeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Transferred over Time [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransferredOverTimeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TransferredOverTimeMember" xlink:to="lab_us-gaap_TransferredOverTimeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_3b4cd1d5-ed69-4ccf-a944-bdb7abfa09e6_terseLabel_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Research and development credits</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_label_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Expired Tax Credits, Research</link:label>
    <link:label id="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_documentation_en-US" xlink:label="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Reconciliation, Expired Tax Credits, Research</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:to="lab_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_78dd77c4-0826-47f7-972b-c84247de5ba7_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lower range of exercise prices (USD per share)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Lower Range Limit</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DemandDepositsMember_7dc6f504-6e17-4bbb-9b18-d65b3b902b1e_terseLabel_en-US" xlink:label="lab_us-gaap_DemandDepositsMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Bank deposits</link:label>
    <link:label id="lab_us-gaap_DemandDepositsMember_label_en-US" xlink:label="lab_us-gaap_DemandDepositsMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Demand Deposits [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DemandDepositsMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DemandDepositsMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DemandDepositsMember" xlink:to="lab_us-gaap_DemandDepositsMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_038de636-39e3-4041-aa4e-bd0e77337e2f_terseLabel_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Third-party portion of milestone payment received</link:label>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_label_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Recognition, Milestone Method Third-Party Portion of Milestone Payment Received</link:label>
    <link:label id="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_documentation_en-US" xlink:label="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Revenue Recognition, Milestone Method Third-Party Portion of Milestone Payment Received</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:to="lab_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_TimingOfTransferOfGoodOrServiceAxis_d5f6d5b5-5ad6-4e96-9ed4-37c28bc6575b_terseLabel_en-US" xlink:label="lab_us-gaap_TimingOfTransferOfGoodOrServiceAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Timing of Transfer of Good or Service [Axis]</link:label>
    <link:label id="lab_us-gaap_TimingOfTransferOfGoodOrServiceAxis_label_en-US" xlink:label="lab_us-gaap_TimingOfTransferOfGoodOrServiceAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Timing of Transfer of Good or Service [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis" xlink:to="lab_us-gaap_TimingOfTransferOfGoodOrServiceAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsForHedgeFinancingActivities_301d74dc-be1b-4651-afc3-5d1a81255bd2_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsForHedgeFinancingActivities" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to convert holders for bond conversion</link:label>
    <link:label id="lab_us-gaap_PaymentsForHedgeFinancingActivities_label_en-US" xlink:label="lab_us-gaap_PaymentsForHedgeFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Hedge, Financing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForHedgeFinancingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForHedgeFinancingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsForHedgeFinancingActivities" xlink:to="lab_us-gaap_PaymentsForHedgeFinancingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeStatementAbstract_7ccd5c4f-5a6a-42c0-8359-70dcd7edb42d_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Condensed Statement of Operations:</link:label>
    <link:label id="lab_us-gaap_IncomeStatementAbstract_label_en-US" xlink:label="lab_us-gaap_IncomeStatementAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Statement [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeStatementAbstract" xlink:to="lab_us-gaap_IncomeStatementAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_ea2094f2-a686-42b7-8e52-7e629a33f6e6_terseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other comprehensive income (loss)</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_d3e286d1-b708-46ac-aae5-6fcae500cab9_terseLabel_en-US" xlink:label="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current expense (benefit):</link:label>
    <link:label id="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_label_en-US" xlink:label="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current Income Tax Expense (Benefit), Continuing Operations [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:to="lab_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_dc82ce78-48ca-4018-a90a-4ab7156d6762_verboseLabel_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense</link:label>
    <link:label id="lab_us-gaap_AmortizationOfIntangibleAssets_label_en-US" xlink:label="lab_us-gaap_AmortizationOfIntangibleAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization of Intangible Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AmortizationOfIntangibleAssets" xlink:to="lab_us-gaap_AmortizationOfIntangibleAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CorporateDebtSecuritiesMember_c5fe69b2-842d-4edb-9627-5e596d0b7b24_terseLabel_en-US" xlink:label="lab_us-gaap_CorporateDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate bonds</link:label>
    <link:label id="lab_us-gaap_CorporateDebtSecuritiesMember_label_en-US" xlink:label="lab_us-gaap_CorporateDebtSecuritiesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Corporate Debt Securities [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CorporateDebtSecuritiesMember" xlink:to="lab_us-gaap_CorporateDebtSecuritiesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_30b899bf-852b-4dca-b3a9-7262847c40a1_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock options (shares)</link:label>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UseOfEstimates_58d53a41-c1ba-4e7e-a942-3a954478661a_verboseLabel_en-US" xlink:label="lab_us-gaap_UseOfEstimates" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Use of Estimates</link:label>
    <link:label id="lab_us-gaap_UseOfEstimates_label_en-US" xlink:label="lab_us-gaap_UseOfEstimates" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Use of Estimates, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UseOfEstimates"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UseOfEstimates" xlink:to="lab_us-gaap_UseOfEstimates" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_7b8f03e8-0d6c-41cb-8b38-e266f27d4676_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible debt</link:label>
    <link:label id="lab_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_label_en-US" xlink:label="lab_us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred Tax Liabilities, Financing Arrangements</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesFinancingArrangements"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:to="lab_us-gaap_DeferredTaxLiabilitiesFinancingArrangements" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_23da0155-c6f2-4170-9c11-bf9e48c32e3d_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Net proceeds from debt issuance</link:label>
    <link:label id="lab_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_label_en-US" xlink:label="lab_us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Debt, Net of Issuance Costs</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:to="lab_us-gaap_ProceedsFromDebtNetOfIssuanceCosts" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_1c224187-dc7e-4951-8eb5-b766d5c27c45_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AssetsCurrent_dcd54fdb-8ceb-4207-b6e6-e835345d2e4a_totalLabel_en-US" xlink:label="lab_us-gaap_AssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total current assets</link:label>
    <link:label id="lab_us-gaap_AssetsCurrent_label_en-US" xlink:label="lab_us-gaap_AssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AssetsCurrent" xlink:to="lab_us-gaap_AssetsCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_fc216e98-6714-4bbe-97f9-304baa7e1d4d_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amortization expense, 2022</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Amortization Expense, Year Four</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_b4f54f2e-683a-4f26-9cb8-2d4fc89cb9a3_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cash paid for acquisition, net of cash acquired</link:label>
    <link:label id="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_label_en-US" xlink:label="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Acquire Businesses, Net of Cash Acquired</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:to="lab_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_TwoThousandTwoStockIncentivePlanMember_ff1c631d-2af4-4d7c-a8ff-0d46d998af33_terseLabel_en-US" xlink:label="lab_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2002 Stock Incentive Plan</link:label>
    <link:label id="lab_lgnd_TwoThousandTwoStockIncentivePlanMember_label_en-US" xlink:label="lab_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Two thousand Two Stock Incentive Plan [Member]</link:label>
    <link:label id="lab_lgnd_TwoThousandTwoStockIncentivePlanMember_documentation_en-US" xlink:label="lab_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Two thousand two Stock Incentive Plan.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:href="lgnd-20181231.xsd#lgnd_TwoThousandTwoStockIncentivePlanMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:to="lab_lgnd_TwoThousandTwoStockIncentivePlanMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfOperatingLeasedAssetsTable_d1a1a98d-a404-426f-ad5e-c871114d832e_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Operating Leased Assets [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfOperatingLeasedAssetsTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Operating Leased Assets [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:to="lab_us-gaap_ScheduleOfOperatingLeasedAssetsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNiMeasurementInput_224b422f-d068-4120-ab33-26b63ed6e9ae_terseLabel_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNiMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement input</link:label>
    <link:label id="lab_us-gaap_EquitySecuritiesFvNiMeasurementInput_label_en-US" xlink:label="lab_us-gaap_EquitySecuritiesFvNiMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Securities, FV-NI, Measurement Input</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiMeasurementInput"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput" xlink:to="lab_us-gaap_EquitySecuritiesFvNiMeasurementInput" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EquityMethodInvestments_84fd4a82-f307-41a6-a149-b26abdd5f932_terseLabel_en-US" xlink:label="lab_us-gaap_EquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Investment in Viking</link:label>
    <link:label id="lab_us-gaap_EquityMethodInvestments_label_en-US" xlink:label="lab_us-gaap_EquityMethodInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Method Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EquityMethodInvestments" xlink:to="lab_us-gaap_EquityMethodInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_54c23839-847e-484c-bde8-61ebdb4d2b96_verboseLabel_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and administrative</link:label>
    <link:label id="lab_us-gaap_GeneralAndAdministrativeExpense_label_en-US" xlink:label="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">General and Administrative Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_GeneralAndAdministrativeExpense" xlink:to="lab_us-gaap_GeneralAndAdministrativeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromSaleOfShortTermInvestments_feb4cc1c-87b8-459a-a958-2651efaa9227_verboseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from sale of short-term investments</link:label>
    <link:label id="lab_us-gaap_ProceedsFromSaleOfShortTermInvestments_label_en-US" xlink:label="lab_us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Sale of Short-term Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:to="lab_us-gaap_ProceedsFromSaleOfShortTermInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_fad62fe7-cbad-4097-8db7-efef5fb371e4_terseLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less: gain from discontinued operations</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" xlink:to="lab_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShortTermInvestments_78b223d1-9746-4a2f-bcb2-fb186e59a7c0_terseLabel_en-US" xlink:label="lab_us-gaap_ShortTermInvestments" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term investments</link:label>
    <link:label id="lab_us-gaap_ShortTermInvestments_label_en-US" xlink:label="lab_us-gaap_ShortTermInvestments" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Short-term Investments</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShortTermInvestments" xlink:to="lab_us-gaap_ShortTermInvestments" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_c990c387-ad70-4e38-9fa6-bee88c58461b_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Rate change for changes in federal or state law</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:to="lab_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_470f4f84-de25-4f91-bfd2-365db2e71c0d_totalLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total liabilities and stockholders&#8217; equity</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquity_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities and Equity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_1f3fb003-1c4b-4236-898e-b3d205bb73b6_verboseLabel_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional paid-in capital</link:label>
    <link:label id="lab_us-gaap_AdditionalPaidInCapital_label_en-US" xlink:label="lab_us-gaap_AdditionalPaidInCapital" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Additional Paid in Capital</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdditionalPaidInCapital" xlink:to="lab_us-gaap_AdditionalPaidInCapital" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LeasesOfLesseeDisclosureTextBlock_b4add5c8-e66c-4083-8843-0a544717d435_verboseLabel_en-US" xlink:label="lab_us-gaap_LeasesOfLesseeDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Lease Obligations</link:label>
    <link:label id="lab_us-gaap_LeasesOfLesseeDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_LeasesOfLesseeDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leases of Lessee Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesOfLesseeDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOfLesseeDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeasesOfLesseeDisclosureTextBlock" xlink:to="lab_us-gaap_LeasesOfLesseeDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_1c11179a-d5aa-4b29-98cd-4989eaf67ba0_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets by Major Class [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_b20a2346-49c2-442e-9918-ac4c9ced360e_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementEquityComponentsAxis_d57221de-7907-4964-b171-3d28d862511c_terseLabel_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Components [Axis]</link:label>
    <link:label id="lab_us-gaap_StatementEquityComponentsAxis_label_en-US" xlink:label="lab_us-gaap_StatementEquityComponentsAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Equity Components [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementEquityComponentsAxis" xlink:to="lab_us-gaap_StatementEquityComponentsAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_746c03bf-1bc6-4660-a7f4-1624c27d0da0_verboseLabel_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contingent liabilities - CyDex</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_label_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Cydex [Member]</link:label>
    <link:label id="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_documentation_en-US" xlink:label="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liability For Contingent Value Rights Company, Cydex</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCydexMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:to="lab_lgnd_LiabilityForContingentValueRightsCompanyCydexMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_75d301e2-c88b-4d82-b7aa-35dc3ab2bdac_verboseLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible assets, net</link:label>
    <link:label id="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets, Net (Excluding Goodwill)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:to="lab_us-gaap_IntangibleAssetsNetExcludingGoodwill" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract_66a6ad8a-0022-44ba-816d-299d981c5de6_verboseLabel_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Dilutive potential common shares:</link:label>
    <link:label id="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract_label_en-US" xlink:label="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Earnings Per Share, Basic and Diluted [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:to="lab_us-gaap_EarningsPerShareBasicAndDilutedAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_c8c990dc-f9d7-4646-8c3b-ab7c4f8f1a5e_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from derivative instrument</link:label>
    <link:label id="lab_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_label_en-US" xlink:label="lab_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Derivative Instrument, Investing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities" xlink:to="lab_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ProceedsFromHedgeFinancingActivities_0427ae7e-5c3c-439d-8c4a-f9695681a0d9_terseLabel_en-US" xlink:label="lab_us-gaap_ProceedsFromHedgeFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from bond hedge</link:label>
    <link:label id="lab_us-gaap_ProceedsFromHedgeFinancingActivities_label_en-US" xlink:label="lab_us-gaap_ProceedsFromHedgeFinancingActivities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Proceeds from Hedge, Financing Activities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromHedgeFinancingActivities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromHedgeFinancingActivities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ProceedsFromHedgeFinancingActivities" xlink:to="lab_us-gaap_ProceedsFromHedgeFinancingActivities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_9212175f-b049-41de-a889-448aa36d1c69_negatedLabel_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other long term assets</link:label>
    <link:label id="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_label_en-US" xlink:label="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Increase (Decrease) in Other Noncurrent Assets</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:to="lab_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_7fb78e75-3cb8-4248-a86e-b64c3a471e4a_netLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2009/role/netLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Diluted (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_5f4d9f73-065a-4779-812b-7aca24b67960_totalLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares used to compute diluted income per share (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_2818e09f-88bd-42ea-bcd1-8f4f29f62e98_verboseLabel_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average shares&#8212;diluted (shares)</link:label>
    <link:label id="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_label_en-US" xlink:label="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted Average Number of Shares Outstanding, Diluted</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:to="lab_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AlternativeInvestmentMeasurementInput_913b4f70-3715-4056-b4b8-050194c27e17_terseLabel_en-US" xlink:label="lab_us-gaap_AlternativeInvestmentMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Measurement input</link:label>
    <link:label id="lab_us-gaap_AlternativeInvestmentMeasurementInput_label_en-US" xlink:label="lab_us-gaap_AlternativeInvestmentMeasurementInput" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Alternative Investment, Measurement Input</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AlternativeInvestmentMeasurementInput" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AlternativeInvestmentMeasurementInput"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AlternativeInvestmentMeasurementInput" xlink:to="lab_us-gaap_AlternativeInvestmentMeasurementInput" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_cb25d9ee-9ac5-45c6-9de1-a1fbd639b8c1_terseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise price of warrants (USD per share)</link:label>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_5ba72147-1c66-40fb-ba70-b611bc3d7926_verboseLabel_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Warrant exercise price (USD per share)</link:label>
    <link:label id="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_label_en-US" xlink:label="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Class of Warrant or Right, Exercise Price of Warrants or Rights</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:to="lab_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_CommonStockSharesIssued_c60e0986-a792-4367-9fa9-32c8e82dcbe9_verboseLabel_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common stock, shares issued (shares)</link:label>
    <link:label id="lab_us-gaap_CommonStockSharesIssued_label_en-US" xlink:label="lab_us-gaap_CommonStockSharesIssued" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Common Stock, Shares, Issued</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_CommonStockSharesIssued" xlink:to="lab_us-gaap_CommonStockSharesIssued" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CydexPharmaceuticalsIncMember_2c3eb8e6-8d3e-4218-b1b7-3e28efbb4c94_verboseLabel_en-US" xlink:label="lab_lgnd_CydexPharmaceuticalsIncMember" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex</link:label>
    <link:label id="lab_lgnd_CydexPharmaceuticalsIncMember_label_en-US" xlink:label="lab_lgnd_CydexPharmaceuticalsIncMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex Pharmaceuticals, Inc [Member]</link:label>
    <link:label id="lab_lgnd_CydexPharmaceuticalsIncMember_documentation_en-US" xlink:label="lab_lgnd_CydexPharmaceuticalsIncMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex Pharmaceuticals, Inc.</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexPharmaceuticalsIncMember" xlink:href="lgnd-20181231.xsd#lgnd_CydexPharmaceuticalsIncMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CydexPharmaceuticalsIncMember" xlink:to="lab_lgnd_CydexPharmaceuticalsIncMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_b23c2d0c-4bcb-4103-9276-51ef874d4359_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Assets:</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_1d29b578-7d7d-479e-a1bc-54a6a80b4703_terseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Options exercisable (shares)</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Exercisable Options</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" xlink:to="lab_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceofConvertibleBondHedge_7cf95643-9142-4c9d-9c11-d238bdf620a3_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceofConvertibleBondHedge" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise price of convertible bond hedge (USD per share)</link:label>
    <link:label id="lab_lgnd_ExercisePriceofConvertibleBondHedge_label_en-US" xlink:label="lab_lgnd_ExercisePriceofConvertibleBondHedge" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price of Convertible Bond Hedge</link:label>
    <link:label id="lab_lgnd_ExercisePriceofConvertibleBondHedge_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceofConvertibleBondHedge" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price of Convertible Bond Hedge</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceofConvertibleBondHedge" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceofConvertibleBondHedge"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceofConvertibleBondHedge" xlink:to="lab_lgnd_ExercisePriceofConvertibleBondHedge" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_57dd1ab7-5c30-4d7d-a532-0ef8d5af4cdd_verboseLabel_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares [Rollforward]</link:label>
    <link:label id="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_label_en-US" xlink:label="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:to="lab_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_ae2e4820-426d-4742-8006-02f1e6f78c77_terseLabel_en-US" xlink:label="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in derivatives</link:label>
    <link:label id="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_label_en-US" xlink:label="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Change in Derivatives</link:label>
    <link:label id="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_documentation_en-US" xlink:label="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Change in Derivatives</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:href="lgnd-20181231.xsd#lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:to="lab_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeThreeMember_4568d4f8-f975-4aa2-ab29-3780f2fe7da1_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeThreeMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$14.47 - $14.47</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeThreeMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeThreeMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Three [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeThreeMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeThreeMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Three [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeThreeMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeThreeMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeThreeMember" xlink:to="lab_lgnd_ExercisePriceRangeThreeMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InternalRevenueServiceIRSMember_1827b388-7dbf-4ef8-af75-bb6159cefe07_terseLabel_en-US" xlink:label="lab_us-gaap_InternalRevenueServiceIRSMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Internal Revenue Service (IRS)</link:label>
    <link:label id="lab_us-gaap_InternalRevenueServiceIRSMember_label_en-US" xlink:label="lab_us-gaap_InternalRevenueServiceIRSMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Internal Revenue Service (IRS) [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InternalRevenueServiceIRSMember" xlink:to="lab_us-gaap_InternalRevenueServiceIRSMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_8ad7d803-3288-4464-9d9f-a10f53b42271_terseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Revenue by Major Customers, by Reporting Segments [Table]</link:label>
    <link:label id="lab_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_label_en-US" xlink:label="lab_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Revenue by Major Customers, by Reporting Segments [Table]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:to="lab_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_11fdee2d-62ba-4edf-8119-8a371c14a84b_terseLabel_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">If-converted value in excess of principal</link:label>
    <link:label id="lab_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_label_en-US" xlink:label="lab_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, If-converted Value in Excess of Principal</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:to="lab_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201615Member_5559733a-a775-4ba6-8d85-4e1ee6adc9c8_terseLabel_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201615Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-15</link:label>
    <link:label id="lab_us-gaap_AccountingStandardsUpdate201615Member_label_en-US" xlink:label="lab_us-gaap_AccountingStandardsUpdate201615Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accounting Standards Update 2016-15 [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201615Member" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201615Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccountingStandardsUpdate201615Member" xlink:to="lab_us-gaap_AccountingStandardsUpdate201615Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_644dadf0-a3a5-459b-a15e-3baed978ce9a_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less: accumulated amortization</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_a3a11d18-12a7-47e8-8fb3-7d8499a8a715_negatedLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less: Accumulated amortization</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Accumulated Amortization</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_5b845733-272e-4796-b192-8c7512ec3792_verboseLabel_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to reconcile net income to net cash provided by operating activities:</link:label>
    <link:label id="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_label_en-US" xlink:label="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:to="lab_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntitySmallBusiness_f50c1ea7-3680-4687-a787-ccf126c7048a_terseLabel_en-US" xlink:label="lab_dei_EntitySmallBusiness" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Small Business</link:label>
    <link:label id="lab_dei_EntitySmallBusiness_label_en-US" xlink:label="lab_dei_EntitySmallBusiness" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Small Business</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitySmallBusiness"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntitySmallBusiness" xlink:to="lab_dei_EntitySmallBusiness" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_9234a0e0-e0a4-48c0-acd5-ce1599623a2d_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value by Liability Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_label_en-US" xlink:label="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value by Liability Class [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:to="lab_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_OwnershipAxis_b86f8f99-85da-450f-8ada-12e22817e234_terseLabel_en-US" xlink:label="lab_srt_OwnershipAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership [Axis]</link:label>
    <link:label id="lab_srt_OwnershipAxis_label_en-US" xlink:label="lab_srt_OwnershipAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Ownership [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_OwnershipAxis" xlink:to="lab_srt_OwnershipAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_0311605c-002e-4d44-99fc-8f514068cbf5_totalLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total consideration</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_cfe5c603-8c87-4a70-b3d4-4c241b3dec5e_terseLabel_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total consideration</link:label>
    <link:label id="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_label_en-US" xlink:label="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:to="lab_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2023Member_db48a8d1-f1dd-40c7-a7b0-911711f7bcfb_terseLabel_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2023Member" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2023 Convertible Senior Notes</link:label>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2023Member_label_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2023Member" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Senior Notes, 2023 [Member]</link:label>
    <link:label id="lab_lgnd_ConvertibleSeniorNotes2023Member_documentation_en-US" xlink:label="lab_lgnd_ConvertibleSeniorNotes2023Member" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Convertible Senior Notes, 2023</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ConvertibleSeniorNotes2023Member" xlink:to="lab_lgnd_ConvertibleSeniorNotes2023Member" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharesOutstanding_72e107a0-31f2-43c7-90c0-dab9a193ae6d_periodStartLabel_en-US" xlink:label="lab_us-gaap_SharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at beginning of period (shares)</link:label>
    <link:label id="lab_us-gaap_SharesOutstanding_c1d1c2ae-116a-467a-acc6-28d389881c7d_periodEndLabel_en-US" xlink:label="lab_us-gaap_SharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at end of period (shares)</link:label>
    <link:label id="lab_us-gaap_SharesOutstanding_label_en-US" xlink:label="lab_us-gaap_SharesOutstanding" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares, Outstanding</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharesOutstanding" xlink:to="lab_us-gaap_SharesOutstanding" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_f2bea8c2-e65c-47f5-894c-31c0acea3343_verboseLabel_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Principles of Consolidation</link:label>
    <link:label id="lab_us-gaap_ConsolidationPolicyTextBlock_label_en-US" xlink:label="lab_us-gaap_ConsolidationPolicyTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Consolidation, Policy [Policy Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConsolidationPolicyTextBlock" xlink:to="lab_us-gaap_ConsolidationPolicyTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_e0408ef6-9129-4031-93e4-aa819d70d698_terseLabel_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income tax receivable</link:label>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_label_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Income Tax Receivables</link:label>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_documentation_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Income Tax Receivables</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:to="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_045a9b23-8ded-479f-9f17-2a90e46ac834_periodStartLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of level 3 financial instruments at beginning of period</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_4c596e59-74ba-485f-a52b-bf13765524ba_periodEndLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of level 3 financial instruments at end of period</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_5cca90ab-f87b-41f5-ab8f-4bf368bef422_verboseLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued liabilities</link:label>
    <link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_fdd12f12-7a19-4df6-b673-1b0e4bf99030_totalLabel_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued liabilities</link:label>
    <link:label id="lab_us-gaap_AccruedLiabilitiesCurrent_label_en-US" xlink:label="lab_us-gaap_AccruedLiabilitiesCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Liabilities, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent" xlink:to="lab_us-gaap_AccruedLiabilitiesCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_b5299963-ddf2-446f-af33-8ff90faf38c1_totalLabel_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total goodwill and other identifiable intangible assets, net</link:label>
    <link:label id="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill_label_en-US" xlink:label="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Intangible Assets, Net (Including Goodwill)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:to="lab_us-gaap_IntangibleAssetsNetIncludingGoodwill" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_01169fb4-0021-4528-ba95-de13a1ece634_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase of common stock</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_39c21bed-7ee2-45b0-8d8c-7cf42641c35d_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares repurchased in period</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodValue_label_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period, Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchasedDuringPeriodValue" xlink:to="lab_us-gaap_StockRepurchasedDuringPeriodValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueLineItems_a935deaf-7a15-4e47-994c-54f6b598f0ba_terseLabel_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disaggregation of Revenue [Line Items]</link:label>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueLineItems_label_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disaggregation of Revenue [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems" xlink:to="lab_us-gaap_DisaggregationOfRevenueLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_2d7daa1e-127f-4a4c-9c8f-1390bc071638_terseLabel_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:label id="lab_us-gaap_FinancialInstrumentAxis_label_en-US" xlink:label="lab_us-gaap_FinancialInstrumentAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Financial Instrument [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FinancialInstrumentAxis" xlink:to="lab_us-gaap_FinancialInstrumentAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_ProductOrServiceAxis_60030fb0-788f-4ccf-8f49-391485027c84_terseLabel_en-US" xlink:label="lab_srt_ProductOrServiceAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Axis]</link:label>
    <link:label id="lab_srt_ProductOrServiceAxis_label_en-US" xlink:label="lab_srt_ProductOrServiceAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Product and Service [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_ProductOrServiceAxis" xlink:to="lab_srt_ProductOrServiceAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_66b582fa-8854-46cc-8a2a-a5f165110bf3_verboseLabel_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depreciation and amortization</link:label>
    <link:label id="lab_us-gaap_DepreciationDepletionAndAmortization_label_en-US" xlink:label="lab_us-gaap_DepreciationDepletionAndAmortization" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Depreciation, Depletion and Amortization</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DepreciationDepletionAndAmortization" xlink:to="lab_us-gaap_DepreciationDepletionAndAmortization" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_CydexMember_798081de-46e5-4362-8c86-f13184ec9034_terseLabel_en-US" xlink:label="lab_lgnd_CydexMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex</link:label>
    <link:label id="lab_lgnd_CydexMember_label_en-US" xlink:label="lab_lgnd_CydexMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex [Member]</link:label>
    <link:label id="lab_lgnd_CydexMember_documentation_en-US" xlink:label="lab_lgnd_CydexMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cydex [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexMember" xlink:href="lgnd-20181231.xsd#lgnd_CydexMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_CydexMember" xlink:to="lab_lgnd_CydexMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_6bb3b97e-b7b2-4bde-9ef6-2fd42731de2f_terseLabel_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Restricted cash</link:label>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_label_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Restricted Cash</link:label>
    <link:label id="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_documentation_en-US" xlink:label="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Restricted Cash</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:to="lab_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherAssetsCurrent_f058d216-68d4-4953-9dcd-6dead5630efe_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other current assets</link:label>
    <link:label id="lab_us-gaap_OtherAssetsCurrent_775d0db8-3fcf-43dd-b428-48598b7c5258_totalLabel_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other current assets</link:label>
    <link:label id="lab_us-gaap_OtherAssetsCurrent_label_en-US" xlink:label="lab_us-gaap_OtherAssetsCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Assets, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherAssetsCurrent" xlink:to="lab_us-gaap_OtherAssetsCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_NonoperatingIncomeExpense_e568aeae-e645-4ae9-80a7-2c3085e2584e_totalLabel_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total other income (expense), net</link:label>
    <link:label id="lab_us-gaap_NonoperatingIncomeExpense_label_en-US" xlink:label="lab_us-gaap_NonoperatingIncomeExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Nonoperating Income (Expense)</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_NonoperatingIncomeExpense" xlink:to="lab_us-gaap_NonoperatingIncomeExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_eafee138-f479-427b-8168-4483b1d35ed4_terseLabel_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entities [Axis]</link:label>
    <link:label id="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_label_en-US" xlink:label="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Variable Interest Entities [Axis]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:to="lab_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_3f05b7dc-0706-4b55-bc6d-755bf65a8468_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Assets and Liabilities Measured on Recurring Basis</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:to="lab_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_7e3196bd-a8ff-4d08-b8c0-6b45e771f80b_terseLabel_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Weighted average exercise price (USD per share)</link:label>
    <link:label id="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_label_en-US" xlink:label="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Exercisable Options, Weighted Average Exercise Price</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" xlink:to="lab_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_467afa95-2144-47c3-a91d-a08bf7662a66_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Current liabilities:</link:label>
    <link:label id="lab_us-gaap_LiabilitiesCurrentAbstract_label_en-US" xlink:label="lab_us-gaap_LiabilitiesCurrentAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities, Current [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract" xlink:to="lab_us-gaap_LiabilitiesCurrentAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_d1feb2ab-620e-4dd9-99fa-f2d64047928a_terseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross unrealized gains</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:to="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_756d4b53-9b17-47a9-80a7-85df10a20a1b_negatedLabel_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercised (shares)</link:label>
    <link:label id="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_label_en-US" xlink:label="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:to="lab_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_b5301c6f-5a71-4abd-9736-b745c58c0a82_verboseLabel_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">LIABILITIES AND STOCKHOLDERS&#8217; EQUITY</link:label>
    <link:label id="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract_label_en-US" xlink:label="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Liabilities and Equity [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:to="lab_us-gaap_LiabilitiesAndStockholdersEquityAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PaymentsforConvertibleBondHedges_19812292-ffcc-474e-ba1a-49e7ed0fe8db_terseLabel_en-US" xlink:label="lab_lgnd_PaymentsforConvertibleBondHedges" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for convertible bond hedges</link:label>
    <link:label id="lab_lgnd_PaymentsforConvertibleBondHedges_label_en-US" xlink:label="lab_lgnd_PaymentsforConvertibleBondHedges" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Convertible Bond Hedges</link:label>
    <link:label id="lab_lgnd_PaymentsforConvertibleBondHedges_documentation_en-US" xlink:label="lab_lgnd_PaymentsforConvertibleBondHedges" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments for Convertible Bond Hedges</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsforConvertibleBondHedges" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsforConvertibleBondHedges"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PaymentsforConvertibleBondHedges" xlink:to="lab_lgnd_PaymentsforConvertibleBondHedges" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LegalMattersAndContingenciesTextBlock_2c10afd5-6969-488e-ac41-3370cf355db5_terseLabel_en-US" xlink:label="lab_us-gaap_LegalMattersAndContingenciesTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Commitments and Contingencies: Legal Proceedings</link:label>
    <link:label id="lab_us-gaap_LegalMattersAndContingenciesTextBlock_label_en-US" xlink:label="lab_us-gaap_LegalMattersAndContingenciesTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Legal Matters and Contingencies [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalMattersAndContingenciesTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LegalMattersAndContingenciesTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LegalMattersAndContingenciesTextBlock" xlink:to="lab_us-gaap_LegalMattersAndContingenciesTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_7ceb485e-6f50-40ab-8f4a-140c172b2071_periodStartLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of level 3 financial instruments at beginning of period</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_05330ffb-07b5-4e44-9e4c-86843f6535dd_periodEndLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair value of level 3 financial instruments at end of period</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:to="lab_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_94663ea7-9cfc-4e02-a1f4-937455c61129_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Taxes</link:label>
    <link:label id="lab_us-gaap_IncomeTaxDisclosureTextBlock_label_en-US" xlink:label="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income Tax Disclosure [Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxDisclosureTextBlock" xlink:to="lab_us-gaap_IncomeTaxDisclosureTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_AziyoandCorMatrixMember_9250498f-adf9-466d-a753-d3d67ba4fbed_terseLabel_en-US" xlink:label="lab_lgnd_AziyoandCorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo &amp; CorMatrix</link:label>
    <link:label id="lab_lgnd_AziyoandCorMatrixMember_label_en-US" xlink:label="lab_lgnd_AziyoandCorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo and CorMatrix [Member]</link:label>
    <link:label id="lab_lgnd_AziyoandCorMatrixMember_documentation_en-US" xlink:label="lab_lgnd_AziyoandCorMatrixMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Aziyo and CorMatrix [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoandCorMatrixMember" xlink:href="lgnd-20181231.xsd#lgnd_AziyoandCorMatrixMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_AziyoandCorMatrixMember" xlink:to="lab_lgnd_AziyoandCorMatrixMember" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_WorkingCapitalAdjustment_54e8f49e-ddac-4b75-ac4c-671e4db8753a_terseLabel_en-US" xlink:label="lab_lgnd_WorkingCapitalAdjustment" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Working capital adjustment</link:label>
    <link:label id="lab_lgnd_WorkingCapitalAdjustment_label_en-US" xlink:label="lab_lgnd_WorkingCapitalAdjustment" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Working Capital Adjustment</link:label>
    <link:label id="lab_lgnd_WorkingCapitalAdjustment_documentation_en-US" xlink:label="lab_lgnd_WorkingCapitalAdjustment" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Working Capital Adjustment</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WorkingCapitalAdjustment" xlink:href="lgnd-20181231.xsd#lgnd_WorkingCapitalAdjustment"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_WorkingCapitalAdjustment" xlink:to="lab_lgnd_WorkingCapitalAdjustment" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_PaymentsOfDebtIssuanceCosts_3952c962-6712-4684-8208-3d92efce3fc4_negatedLabel_en-US" xlink:label="lab_us-gaap_PaymentsOfDebtIssuanceCosts" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payment of debt issuance costs</link:label>
    <link:label id="lab_us-gaap_PaymentsOfDebtIssuanceCosts_label_en-US" xlink:label="lab_us-gaap_PaymentsOfDebtIssuanceCosts" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments of Debt Issuance Costs</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_PaymentsOfDebtIssuanceCosts" xlink:to="lab_us-gaap_PaymentsOfDebtIssuanceCosts" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_12fbdc86-02ac-4288-a39c-2a08d5e9b14b_totalLabel_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income from discontinued operations</link:label>
    <link:label id="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_label_en-US" xlink:label="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:to="lab_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StatementOfCashFlowsAbstract_label_en-US" xlink:label="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Statement of Cash Flows [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract" xlink:to="lab_us-gaap_StatementOfCashFlowsAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_InterestExpense_00e94296-5179-4e88-b24f-d1e195ccbd2b_negatedLabel_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest expense</link:label>
    <link:label id="lab_us-gaap_InterestExpense_label_en-US" xlink:label="lab_us-gaap_InterestExpense" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Interest Expense</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_InterestExpense" xlink:to="lab_us-gaap_InterestExpense" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_94b13590-3b75-42cf-963b-bf8f155de092_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Gross unrealized losses</link:label>
    <link:label id="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_label_en-US" xlink:label="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:to="lab_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_84c40c42-5d02-43d0-8297-69aa5a9d87c7_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income from discontinued operations (USD per share)</link:label>
    <link:label id="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_label_en-US" xlink:label="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:to="lab_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_ee71fffa-554a-4077-bfab-d3bbf161d250_terseLabel_en-US" xlink:label="lab_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amounts owed to former licensees</link:label>
    <link:label id="lab_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_label_en-US" xlink:label="lab_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Accrued Sales Commission</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedSalesCommissionCurrentAndNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent" xlink:to="lab_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_c72981b1-0c92-4bc4-b5b2-688494f51ddd_terseLabel_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Maximum threshold of debt trading price trigger (as a percent)</link:label>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_label_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Maximum Threshold Percentage of Debt Trading Price Trigger</link:label>
    <link:label id="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_documentation_en-US" xlink:label="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Debt Instrument, Convertible, Maximum Threshold Percentage of Debt Trading Price Trigger</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:to="lab_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ContractWithCustomerLiabilityCurrent_42ada67a-aa1b-466c-83f0-715617d7165e_terseLabel_en-US" xlink:label="lab_us-gaap_ContractWithCustomerLiabilityCurrent" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Deferred revenue</link:label>
    <link:label id="lab_us-gaap_ContractWithCustomerLiabilityCurrent_label_en-US" xlink:label="lab_us-gaap_ContractWithCustomerLiabilityCurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Contract with Customer, Liability, Current</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ContractWithCustomerLiabilityCurrent" xlink:to="lab_us-gaap_ContractWithCustomerLiabilityCurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_LeasesAbstract_label_en-US" xlink:label="lab_us-gaap_LeasesAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Leases [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_LeasesAbstract" xlink:to="lab_us-gaap_LeasesAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_MilestoneMember_497e118b-02c5-4efd-b7f4-d8dc1ae4a16b_terseLabel_en-US" xlink:label="lab_lgnd_MilestoneMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestones</link:label>
    <link:label id="lab_lgnd_MilestoneMember_label_en-US" xlink:label="lab_lgnd_MilestoneMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone [Member]</link:label>
    <link:label id="lab_lgnd_MilestoneMember_documentation_en-US" xlink:label="lab_lgnd_MilestoneMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Milestone</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestoneMember" xlink:href="lgnd-20181231.xsd#lgnd_MilestoneMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_MilestoneMember" xlink:to="lab_lgnd_MilestoneMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_faac3217-945e-404f-b981-71dcd36dcc5a_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets, Major Class Name [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_srt_MinimumMember_96001047-2695-4df7-b7a2-68bb267c085a_terseLabel_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Minimum</link:label>
    <link:label id="lab_srt_MinimumMember_label_en-US" xlink:label="lab_srt_MinimumMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Minimum [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_srt_MinimumMember" xlink:to="lab_srt_MinimumMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OperatingCostsAndExpenses_26560cfb-1657-4b7a-a817-90b3fcf1d662_totalLabel_en-US" xlink:label="lab_us-gaap_OperatingCostsAndExpenses" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total operating costs and expenses</link:label>
    <link:label id="lab_us-gaap_OperatingCostsAndExpenses_e8d0e06e-936f-48e5-9664-adaa9639314d_terseLabel_en-US" xlink:label="lab_us-gaap_OperatingCostsAndExpenses" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total operating costs and expenses</link:label>
    <link:label id="lab_us-gaap_OperatingCostsAndExpenses_label_en-US" xlink:label="lab_us-gaap_OperatingCostsAndExpenses" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Costs and Expenses</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OperatingCostsAndExpenses" xlink:to="lab_us-gaap_OperatingCostsAndExpenses" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ConcentrationRiskPercentage1_6363e480-b081-45a7-b37d-b2bb494444f0_terseLabel_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Total revenues (as a percent)</link:label>
    <link:label id="lab_us-gaap_ConcentrationRiskPercentage1_label_en-US" xlink:label="lab_us-gaap_ConcentrationRiskPercentage1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Concentration Risk, Percentage</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ConcentrationRiskPercentage1" xlink:to="lab_us-gaap_ConcentrationRiskPercentage1" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_ExercisePriceRangeEightMember_85129c0a-4b15-4c6c-b511-21fe57512129_terseLabel_en-US" xlink:label="lab_lgnd_ExercisePriceRangeEightMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">$101.15 - $195.91</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeEightMember_label_en-US" xlink:label="lab_lgnd_ExercisePriceRangeEightMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Eight [Member]</link:label>
    <link:label id="lab_lgnd_ExercisePriceRangeEightMember_documentation_en-US" xlink:label="lab_lgnd_ExercisePriceRangeEightMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Exercise Price Range Eight [Member]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeEightMember" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeEightMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_ExercisePriceRangeEightMember" xlink:to="lab_lgnd_ExercisePriceRangeEightMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_a45a31e8-9649-4589-b499-b8bdc2cb62bc_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Less:Reclassification of net realized gains included in net income (loss), net of tax</link:label>
    <link:label id="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_label_en-US" xlink:label="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:to="lab_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefits_26666eda-2baa-4935-a555-ebc9832761dd_periodStartLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefits" xlink:role="http://www.xbrl.org/2003/role/periodStartLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at beginning of period</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefits_4d526680-7a6c-4582-8875-8a02f92f58a4_periodEndLabel_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefits" xlink:role="http://www.xbrl.org/2003/role/periodEndLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Balance at end of period</link:label>
    <link:label id="lab_us-gaap_UnrecognizedTaxBenefits_label_en-US" xlink:label="lab_us-gaap_UnrecognizedTaxBenefits" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized Tax Benefits</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_UnrecognizedTaxBenefits" xlink:to="lab_us-gaap_UnrecognizedTaxBenefits" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_LicenseFeesMember_cb37defd-58a7-4adc-86b4-12d0d520203d_terseLabel_en-US" xlink:label="lab_lgnd_LicenseFeesMember" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License fees</link:label>
    <link:label id="lab_lgnd_LicenseFeesMember_label_en-US" xlink:label="lab_lgnd_LicenseFeesMember" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees [Member]</link:label>
    <link:label id="lab_lgnd_LicenseFeesMember_documentation_en-US" xlink:label="lab_lgnd_LicenseFeesMember" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">License Fees</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMember" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMember"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_LicenseFeesMember" xlink:to="lab_lgnd_LicenseFeesMember" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueTableTextBlock_5f2a231d-5b28-4538-8577-c6957c64ac27_terseLabel_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Disaggregation of Revenue</link:label>
    <link:label id="lab_us-gaap_DisaggregationOfRevenueTableTextBlock_label_en-US" xlink:label="lab_us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Disaggregation of Revenue [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:to="lab_us-gaap_DisaggregationOfRevenueTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_13a18e8a-9b5c-4d65-bd3c-124a92417870_terseLabel_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</link:label>
    <link:label id="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems_label_en-US" xlink:label="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Finite-Lived Intangible Assets [Line Items]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:to="lab_us-gaap_FiniteLivedIntangibleAssetsLineItems" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_a64974a2-f560-4bd9-a6fe-178389b2fced_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement Frequency [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueMeasurementFrequencyDomain_label_en-US" xlink:label="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value, Measurement Frequency [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain" xlink:to="lab_us-gaap_FairValueMeasurementFrequencyDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_0a6aa3ef-32f2-4ae8-9915-ad1cdac10faf_terseLabel_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">2019 Convertible Senior Notes (shares)</link:label>
    <link:label id="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_label_en-US" xlink:label="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:to="lab_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_5f3b5bf0-b857-4c1b-9809-d2a138f75e7b_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other long-term liabilities</link:label>
    <link:label id="lab_us-gaap_OtherLiabilitiesNoncurrent_label_en-US" xlink:label="lab_us-gaap_OtherLiabilitiesNoncurrent" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Liabilities, Noncurrent</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherLiabilitiesNoncurrent" xlink:to="lab_us-gaap_OtherLiabilitiesNoncurrent" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_69442a80-8602-4c93-becc-9e6fb956bf0b_totalLabel_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:role="http://www.xbrl.org/2003/role/totalLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating lease obligation, Less than 1 year, net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_label_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Next Twelve Months, Net</link:label>
    <link:label id="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_documentation_en-US" xlink:label="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Operating Leases, Future Minimum Payments Due, Next Twelve Months, Net</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:to="lab_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_c99c36f9-b1f2-4ddc-857e-ebf91376f955_verboseLabel_en-US" xlink:label="lab_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Goodwill and Other Identifiable Intangible Assets</link:label>
    <link:label id="lab_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_label_en-US" xlink:label="lab_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Schedule of Intangible Assets and Goodwill [Table Text Block]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:to="lab_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_f64d3a65-af0b-45dc-98e0-3f830651e6a5_verboseLabel_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other income (expense):</link:label>
    <link:label id="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract_label_en-US" xlink:label="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Other Nonoperating Income (Expense) [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:to="lab_us-gaap_OtherNonoperatingIncomeExpenseAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_13ce386c-f00f-46a1-808b-e5ee5e9f0a2a_verboseLabel_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" xlink:role="http://www.xbrl.org/2003/role/verboseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Unrecognized compensation cost, restricted stock</link:label>
    <link:label id="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_label_en-US" xlink:label="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" xlink:to="lab_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions" xlink:type="arc" order="1"/>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_37af264a-0bbc-4298-9843-37dfe796d94c_negatedLabel_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:role="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to CVR holders</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_label_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Contingent Value Right Holders, Financing Activity</link:label>
    <link:label id="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_documentation_en-US" xlink:label="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:role="http://www.xbrl.org/2003/role/documentation" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Payments to Contingent Value Right Holders, Financing Activity</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersFinancingActivity"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:to="lab_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_0ac8fa13-e89d-4a3e-8612-58c34603d9b6_terseLabel_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Fair Value by Asset Class [Domain]</link:label>
    <link:label id="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_label_en-US" xlink:label="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Asset Class [Domain]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:to="lab_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_cf5701c2-c6dc-4903-8a95-13c09365261b_terseLabel_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Change in valuation allowance</link:label>
    <link:label id="lab_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_label_en-US" xlink:label="lab_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:to="lab_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance" xlink:type="arc" order="1"/>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodShares_2a623dce-7de8-4a04-b59a-008e380fc107_negatedTerseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodShares" xlink:role="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Repurchase of common stock (shares)</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodShares_0116e7fa-8c9d-44b3-9274-9e68ad8eb926_terseLabel_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodShares" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Shares repurchased in period (shares)</link:label>
    <link:label id="lab_us-gaap_StockRepurchasedDuringPeriodShares_label_en-US" xlink:label="lab_us-gaap_StockRepurchasedDuringPeriodShares" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Stock Repurchased During Period, Shares</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_us-gaap_StockRepurchasedDuringPeriodShares" xlink:to="lab_us-gaap_StockRepurchasedDuringPeriodShares" xlink:type="arc" order="1"/>
  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>12
<FILENAME>lgnd-20181231_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2017 Workiva-->
<!--r:8e65e77b-65c1-4661-bd5e-cc250bb19364,g:0316820b-dd5f-4af7-ba98-d3bd354ae913-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#DocumentandEntityInformation"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/DocumentandEntityInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:href="lgnd-20181231.xsd#lgnd_DocumentAndEntityInformationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_eebc1810-b4c0-428a-8a50-4faf8bba8ca0" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityRegistrantName_eebc1810-b4c0-428a-8a50-4faf8bba8ca0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_760d7849-42cf-40ba-b6c7-804fe8b4cb80" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityCentralIndexKey_760d7849-42cf-40ba-b6c7-804fe8b4cb80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_8315650d-f097-4850-b8a5-a260ef1c5ec5" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentType"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_DocumentType_8315650d-f097-4850-b8a5-a260ef1c5ec5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_57bdf6bb-c5a4-4825-a57c-4a60a8b2b6ec" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_DocumentPeriodEndDate_57bdf6bb-c5a4-4825-a57c-4a60a8b2b6ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_47940226-8c47-4e14-a5ab-adbe86092463" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_AmendmentFlag_47940226-8c47-4e14-a5ab-adbe86092463" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_48468395-8a0a-48a0-b679-0f197333d47f" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_DocumentFiscalYearFocus_48468395-8a0a-48a0-b679-0f197333d47f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_53d26cb2-31e5-4f04-aedd-ca44d75efd35" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_DocumentFiscalPeriodFocus_53d26cb2-31e5-4f04-aedd-ca44d75efd35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_515049f4-8204-4582-acdf-b96840a51071" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_CurrentFiscalYearEndDate_515049f4-8204-4582-acdf-b96840a51071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_72eafb46-a174-4b2a-80de-954d04495367" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityFilerCategory_72eafb46-a174-4b2a-80de-954d04495367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_05cc2ae0-c416-459e-ade8-b416b56e4033" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityEmergingGrowthCompany_05cc2ae0-c416-459e-ade8-b416b56e4033" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_a68ede2a-0396-420f-9f17-c1da430e5418" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntitySmallBusiness_a68ede2a-0396-420f-9f17-c1da430e5418" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_23fbcaaa-747b-4984-9972-0ca4d7a904b5" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityShellCompany_23fbcaaa-747b-4984-9972-0ca4d7a904b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_b597fab4-d673-4ed2-b3c5-a548b51d13c4" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_b597fab4-d673-4ed2-b3c5-a548b51d13c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityPublicFloat_3ff89abd-a937-4756-9f19-48558779b374" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityPublicFloat"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityPublicFloat_3ff89abd-a937-4756-9f19-48558779b374" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityVoluntaryFilers_765f7dc1-471d-487d-9a96-9c25082646ee" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityVoluntaryFilers"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityVoluntaryFilers_765f7dc1-471d-487d-9a96-9c25082646ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityWellKnownSeasonedIssuer_d729a069-b844-474c-b0e7-0c265187adfc" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityWellKnownSeasonedIssuer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityWellKnownSeasonedIssuer_d729a069-b844-474c-b0e7-0c265187adfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_3f88b106-7109-4e75-8637-b445cafcf3ac" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_DocumentAndEntityInformationAbstract_8b5464f8-728f-43c1-8e80-092d302fc2f5" xlink:to="loc_dei_EntityCurrentReportingStatus_3f88b106-7109-4e75-8637-b445cafcf3ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETS"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_d28691c9-ee9b-46b4-8044-9338e5fa58ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_d28691c9-ee9b-46b4-8044-9338e5fa58ae" xlink:to="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4539da23-0a4b-4a69-942d-567d9f857909" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_4539da23-0a4b-4a69-942d-567d9f857909" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_d8c28ab4-be15-4617-97e5-aad7fe4d1ae2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_ShortTermInvestments_d8c28ab4-be15-4617-97e5-aad7fe4d1ae2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNi_d3de1150-2493-4a63-b7e7-e0688a199754" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNi"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_EquitySecuritiesFvNi_d3de1150-2493-4a63-b7e7-e0688a199754" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReceivablesNetCurrent_3fed467e-e531-4b0c-b4b9-b221ebf98d17" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReceivablesNetCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_ReceivablesNetCurrent_3fed467e-e531-4b0c-b4b9-b221ebf98d17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesAndLoansReceivableGrossCurrent_1914a34d-7ad7-4216-8b98-7f0fc25e8301" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesAndLoansReceivableGrossCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_NotesAndLoansReceivableGrossCurrent_1914a34d-7ad7-4216-8b98-7f0fc25e8301" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_de0ffe4d-aa81-4c23-9906-227b0f7423a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryNet"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_InventoryNet_de0ffe4d-aa81-4c23-9906-227b0f7423a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_748da8bd-d46d-4b88-b47f-070358cbb832" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_748da8bd-d46d-4b88-b47f-070358cbb832" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_a8259c61-f1d8-4e29-9da2-45c5fb68b12e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_OtherAssetsCurrent_a8259c61-f1d8-4e29-9da2-45c5fb68b12e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_bd6d7b94-4a34-4b66-86e9-e3513045b52c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_2e4ff5ba-8710-408d-a608-b481159a1d99" xlink:to="loc_us-gaap_AssetsCurrent_bd6d7b94-4a34-4b66-86e9-e3513045b52c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxAssetsNet_6bc43aff-fc85-4029-ba19-385c1395b5fe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxAssetsNet"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_DeferredIncomeTaxAssetsNet_6bc43aff-fc85-4029-ba19-385c1395b5fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestments_11d4221b-c434-4712-9db0-1758af02f21d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestments"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_EquityMethodInvestments_11d4221b-c434-4712-9db0-1758af02f21d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_f9112e54-d94c-4675-bd42-3c3d40785661" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_f9112e54-d94c-4675-bd42-3c3d40785661" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_da2bb3bd-81b5-4adf-854e-74a2207b4fc3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_Goodwill_da2bb3bd-81b5-4adf-854e-74a2207b4fc3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CommercialLicenseRights_44b169c0-939f-4ad0-a5e9-4ba57d942e2d" xlink:href="lgnd-20181231.xsd#lgnd_CommercialLicenseRights"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_lgnd_CommercialLicenseRights_44b169c0-939f-4ad0-a5e9-4ba57d942e2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_7b258d4a-5b33-47af-921c-e50bc08289e6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_7b258d4a-5b33-47af-921c-e50bc08289e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_641e998b-cde5-468d-9989-973d28bba2b5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_641e998b-cde5-468d-9989-973d28bba2b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_1485ab93-f842-4121-95d1-3afa43abc54c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Assets"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ad98965-8245-40e1-9bd3-cc1bea2ed97f" xlink:to="loc_us-gaap_Assets_1485ab93-f842-4121-95d1-3afa43abc54c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_d28691c9-ee9b-46b4-8044-9338e5fa58ae" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:to="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_c1d2aeb9-69bc-4a5c-9088-63b7ec76d22b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_AccountsPayableCurrent_c1d2aeb9-69bc-4a5c-9088-63b7ec76d22b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_e3c535c3-4365-40c2-9a42-63478efabdbf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_e3c535c3-4365-40c2-9a42-63478efabdbf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights_f6173cdb-a943-49cc-b58c-ce268ce7bb0c" xlink:href="lgnd-20181231.xsd#lgnd_CurrentPortionOfLiabilityForContingentValueRights"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_lgnd_CurrentPortionOfLiabilityForContingentValueRights_f6173cdb-a943-49cc-b58c-ce268ce7bb0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_bacb2c06-2262-46b6-9140-a1b954ae138b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_bacb2c06-2262-46b6-9140-a1b954ae138b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilitiesCurrent_5881117e-3a70-4349-b5a0-68006b74553e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilitiesCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_DerivativeLiabilitiesCurrent_5881117e-3a70-4349-b5a0-68006b74553e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtCurrent_881d1e9b-3b0a-467b-a641-826f2f561625" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_ConvertibleDebtCurrent_881d1e9b-3b0a-467b-a641-826f2f561625" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_3c2772d7-95bc-49f6-ab50-43ffe39e0bd9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_94543d29-fda9-44d6-9d1a-d74d59286281" xlink:to="loc_us-gaap_LiabilitiesCurrent_3c2772d7-95bc-49f6-ab50-43ffe39e0bd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_d25474ed-54a5-4f67-8a9e-12270e7a6e67" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_d25474ed-54a5-4f67-8a9e-12270e7a6e67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRights_607a569f-d072-46e0-a8aa-79fc66cca284" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRights"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:to="loc_lgnd_LiabilityForContingentValueRights_607a569f-d072-46e0-a8aa-79fc66cca284" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_f46698a6-98a5-4fa0-a874-435a0dbd080f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_f46698a6-98a5-4fa0-a874-435a0dbd080f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_c4d18f21-bcc9-46d7-b86a-993304bcfca8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAbstract_c512f4f1-52e3-4945-8ccc-97e3fb24b769" xlink:to="loc_us-gaap_Liabilities_c4d18f21-bcc9-46d7-b86a-993304bcfca8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_1ab3e567-7aa1-4b59-9a0f-4db5df7f2f6e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:to="loc_us-gaap_CommitmentsAndContingencies_1ab3e567-7aa1-4b59-9a0f-4db5df7f2f6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_09850077-8a03-4192-80bf-7a1876017c0d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_09850077-8a03-4192-80bf-7a1876017c0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:to="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_711e324a-b228-42bf-9ded-dc6f1eac9ead" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:to="loc_us-gaap_CommonStockValue_711e324a-b228-42bf-9ded-dc6f1eac9ead" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_f2ea0f4f-7dc4-41a7-a099-0ac0699d1aab" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:to="loc_us-gaap_AdditionalPaidInCapital_f2ea0f4f-7dc4-41a7-a099-0ac0699d1aab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_baac7351-872b-4db7-b170-9a6a09fdd63c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_baac7351-872b-4db7-b170-9a6a09fdd63c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_fd9d72b5-fd78-4d7c-9f10-35086d36c21d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_fd9d72b5-fd78-4d7c-9f10-35086d36c21d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_301ae5d9-4d45-4b6e-932e-639f14864c18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_f5855c66-600a-4d08-b9c1-d744c69925be" xlink:to="loc_us-gaap_StockholdersEquity_301ae5d9-4d45-4b6e-932e-639f14864c18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_818898c4-8ab4-4306-a638-0da9832cf342" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_524ef13f-4b79-4d44-a247-1da89528c8ff" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_818898c4-8ab4-4306-a638-0da9832cf342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDBALANCESHEETSParenthetical"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_88cc96e6-4caf-46eb-bd41-16c2ea46fd65" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_ba2598c4-efe2-467e-8b53-4da5fdccd98e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_88cc96e6-4caf-46eb-bd41-16c2ea46fd65" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_ba2598c4-efe2-467e-8b53-4da5fdccd98e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_cabd4ade-f261-4361-afee-6733e88a35ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_88cc96e6-4caf-46eb-bd41-16c2ea46fd65" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_cabd4ade-f261-4361-afee-6733e88a35ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_fa5a26e8-24ad-4108-b78f-ad9760afa55b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_88cc96e6-4caf-46eb-bd41-16c2ea46fd65" xlink:to="loc_us-gaap_CommonStockSharesIssued_fa5a26e8-24ad-4108-b78f-ad9760afa55b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_31d6f5b8-34a2-4c97-b884-38b11e6db1c2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_88cc96e6-4caf-46eb-bd41-16c2ea46fd65" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_31d6f5b8-34a2-4c97-b884-38b11e6db1c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONS"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementAbstract_a5a3556e-4248-42ff-b05a-7b4bf5a53edc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementAbstract_a5a3556e-4248-42ff-b05a-7b4bf5a53edc" xlink:to="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:to="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_17bc3a69-de45-4e5a-9ff7-c0ec3ed5f992" xlink:to="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_97fd9271-521f-48ff-b8c2-4efd7717459d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_us-gaap_RoyaltyMember_97fd9271-521f-48ff-b8c2-4efd7717459d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaterialSalesCaptisolMember_1eeb8e3f-af69-4085-a90a-530b1378e090" xlink:href="lgnd-20181231.xsd#lgnd_MaterialSalesCaptisolMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_lgnd_MaterialSalesCaptisolMember_1eeb8e3f-af69-4085-a90a-530b1378e090" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_df0778ff-628b-4fbe-8eef-46d3b4a9915d" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesandProductOtherMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_5e1ae01d-7ad6-419d-a45e-82724cfc4184" xlink:to="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_df0778ff-628b-4fbe-8eef-46d3b4a9915d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_09eac838-4586-4905-b726-1ceea54f938b" xlink:to="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenuesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3065c35b-8bc6-4fd9-8e30-b457f02757ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RevenuesAbstract_06b87996-7bc7-48a9-89a4-36f5169ddb4e" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_3065c35b-8bc6-4fd9-8e30-b457f02757ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_0820c8cf-0ddc-4039-a7aa-2a8932f50dc5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_0820c8cf-0ddc-4039-a7aa-2a8932f50dc5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_1d161703-5c47-420a-b607-28f760bfd152" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CostOfGoodsAndServicesSoldAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSoldAmortization_1d161703-5c47-420a-b607-28f760bfd152" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_fefcdf23-e73c-4aca-b35d-4f849fdc6294" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_fefcdf23-e73c-4aca-b35d-4f849fdc6294" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_dd3bb6d0-6a62-4208-bd07-946fc0808f72" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_dd3bb6d0-6a62-4208-bd07-946fc0808f72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_25ef6164-501f-4502-ac52-7585ac430269" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingCostsAndExpensesAbstract_2d616a71-8aa8-490a-b720-c03b8e820bf9" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_25ef6164-501f-4502-ac52-7585ac430269" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_c16b6e44-489c-41c7-90fa-e5bc9f8dccb9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OperatingIncomeLoss_c16b6e44-489c-41c7-90fa-e5bc9f8dccb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiGainLoss_fa6d7c3e-852a-430d-af6b-e91d3fa4b2bc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiGainLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_EquitySecuritiesFvNiGainLoss_fa6d7c3e-852a-430d-af6b-e91d3fa4b2bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeNonoperating_c9e932f8-abdb-4612-8a00-98c67e7dae0a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentIncomeNonoperating"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_InvestmentIncomeNonoperating_c9e932f8-abdb-4612-8a00-98c67e7dae0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_9c249e49-1b52-4df7-a41b-77f2103942cf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_InterestExpense_9c249e49-1b52-4df7-a41b-77f2103942cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_c4cc1b15-20b0-42fb-8329-8165a641e662" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_c4cc1b15-20b0-42fb-8329-8165a641e662" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_ded709e0-d299-43a4-b3bb-5bce41d18ed2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_7c6033c5-8ff5-49d5-9fe1-f2b0919cbc20" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_ded709e0-d299-43a4-b3bb-5bce41d18ed2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_aef0ba80-1cac-4a46-bb61-4d098b05d8a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments_aef0ba80-1cac-4a46-bb61-4d098b05d8a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_82e56b54-146b-4afb-8422-bf9de1f4246f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_82e56b54-146b-4afb-8422-bf9de1f4246f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_72758937-63d6-4128-b128-8326f2f7f4b2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_72758937-63d6-4128-b128-8326f2f7f4b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_ba40df40-871f-4a34-a824-9ff287fc6fcc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax_ba40df40-871f-4a34-a824-9ff287fc6fcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_99800c27-8376-456b-82b1-b880923892ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_99800c27-8376-456b-82b1-b880923892ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_f40c13b2-8c5f-488c-b709-0849d1e20e69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract_60c9df13-2166-4c79-9b89-b053b49c6a5e" xlink:to="loc_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax_f40c13b2-8c5f-488c-b709-0849d1e20e69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_8c56e3ef-68d5-4052-8bb9-c65a02cbe1d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_NetIncomeLoss_8c56e3ef-68d5-4052-8bb9-c65a02cbe1d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_99e494a2-ea26-4005-b3e8-6699bab614b1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerBasicShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare_99e494a2-ea26-4005-b3e8-6699bab614b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_0bf267f7-3c6d-4de9-9dfd-8c2f2390b174" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare_0bf267f7-3c6d-4de9-9dfd-8c2f2390b174" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_2789148d-6a2a-4875-807e-f532069798f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_5cde416d-8d55-489a-98ba-e4ce97485e3b" xlink:to="loc_us-gaap_EarningsPerShareBasic_2789148d-6a2a-4875-807e-f532069798f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_616f908b-dfc3-4f4c-90ce-4d43cfd3f0aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare_616f908b-dfc3-4f4c-90ce-4d43cfd3f0aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_ae345b3e-d0de-44af-b579-ffa471a30a3f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare_ae345b3e-d0de-44af-b579-ffa471a30a3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_2cb2f160-876c-4445-a132-f8f78edd422e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_0a32be3d-37fc-49a2-964c-a106ca2a169c" xlink:to="loc_us-gaap_EarningsPerShareDiluted_2cb2f160-876c-4445-a132-f8f78edd422e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_082306cd-0a2d-4f66-9bf1-2c3b920c2e2c" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_75289b1d-9e73-41fc-9264-b5dc015c1450" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_75289b1d-9e73-41fc-9264-b5dc015c1450" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e7a55070-f6d8-45a2-98c8-466b97080492" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract_3252ca0d-c893-45ea-870a-0b1286e28869" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e7a55070-f6d8-45a2-98c8-466b97080492" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_c476ba68-663a-4c61-8726-e4770a349451" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:to="loc_us-gaap_NetIncomeLoss_c476ba68-663a-4c61-8726-e4770a349451" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_6db45293-9bd1-466b-a45a-6f6db1c66633" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_6db45293-9bd1-466b-a45a-6f6db1c66633" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_71d53e2c-6e7d-49d1-9cd4-f96f72c7f52e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax_71d53e2c-6e7d-49d1-9cd4-f96f72c7f52e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_7ae79e3e-e246-4761-9855-39b585c806f3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax_7ae79e3e-e246-4761-9855-39b585c806f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_e6bed34e-e49e-4388-a9e7-9f22c1981765" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_87ceceed-e90a-43d8-b713-59b15ecdc2ce" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_e6bed34e-e49e-4388-a9e7-9f22c1981765" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_2531d16d-ff1c-4f4b-b54a-d6c71b36676d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_2531d16d-ff1c-4f4b-b54a-d6c71b36676d" xlink:to="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f75100fb-70c3-4d30-9b69-7a1727435806" xlink:to="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_3321fcb5-3753-448c-b544-2935e21caac9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_CommonStockMember_3321fcb5-3753-448c-b544-2935e21caac9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_e5c637b9-d5a7-49cc-bdba-17754794eafd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_e5c637b9-d5a7-49cc-bdba-17754794eafd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_14894e93-afc8-4b61-9d9b-f16c21498cfc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeMember_14894e93-afc8-4b61-9d9b-f16c21498cfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_00f9714c-f20d-4f04-91ff-b443323e83ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_ac1c166e-0c01-4709-8c44-dd8c5fffc855" xlink:to="loc_us-gaap_RetainedEarningsMember_00f9714c-f20d-4f04-91ff-b443323e83ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_9dedbc1a-a766-49d4-aeb8-ccbaabfd71e9" xlink:to="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201609Member_6cca0897-4a5f-4a94-a75a-bc8f3c1c93a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201609Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201609Member_6cca0897-4a5f-4a94-a75a-bc8f3c1c93a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_91241eea-4cad-47cf-86dd-119a4285a5ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_91241eea-4cad-47cf-86dd-119a4285a5ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_2d7fb536-9d4e-45be-b4c4-fe821d8a4403" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_3422b543-6008-4c5c-a8e5-f68178ad04d7" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_2d7fb536-9d4e-45be-b4c4-fe821d8a4403" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_8db9ff5a-6a9f-49ee-bd71-b953aa800a61" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_fe51a561-b9a1-4cd9-a802-3a1182ecd29d" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_fe51a561-b9a1-4cd9-a802-3a1182ecd29d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_50d5fc12-5354-45c0-8f45-86cb795e0c62" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_efcae488-2fc5-4ccb-9efd-258d777a0516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_50d5fc12-5354-45c0-8f45-86cb795e0c62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_eeadd10e-8e94-4371-8e51-9cbc21d76b65" xlink:to="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_021d399b-532b-4d91-a444-4587ed4265b0" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_28f79867-b9af-4f24-89ec-d74419b15f85" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_SharesOutstanding_28f79867-b9af-4f24-89ec-d74419b15f85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d60db225-2983-4213-810b-2b41bc0bf583" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d60db225-2983-4213-810b-2b41bc0bf583" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_c40f11db-2d6a-419b-b044-693f9d7629ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans_c40f11db-2d6a-419b-b044-693f9d7629ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_7119d87b-f931-42e1-9a06-6840b989be67" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation_7119d87b-f931-42e1-9a06-6840b989be67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_a9a9a7b6-c331-4972-a159-180b09b6cac0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_a9a9a7b6-c331-4972-a159-180b09b6cac0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3036073c-e79b-4ee2-b8c4-c4d56279fabd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3036073c-e79b-4ee2-b8c4-c4d56279fabd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_1ef9df53-8e5e-45f7-ad2a-aa733d14c0cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_1ef9df53-8e5e-45f7-ad2a-aa733d14c0cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_3d456c73-d5fa-4cf7-8839-7615e9923692" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_3d456c73-d5fa-4cf7-8839-7615e9923692" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_1b468c1b-b97f-4f01-a838-27c08e6d800a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_1b468c1b-b97f-4f01-a838-27c08e6d800a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_a4f2fc0f-7a2f-412a-8a9d-02703cac4439" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_a4f2fc0f-7a2f-412a-8a9d-02703cac4439" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5006ae87-a56d-49b0-85c5-4ab0da01207a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTax"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTax_5006ae87-a56d-49b0-85c5-4ab0da01207a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_921f48af-ec11-4dc1-9880-8081eb5b2b98" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_921f48af-ec11-4dc1-9880-8081eb5b2b98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_4ccf0c34-8538-4d83-8590-1a918f8991c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature_4ccf0c34-8538-4d83-8590-1a918f8991c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_e7a58819-d9e5-4368-8aa2-09a64ceffd06" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes_e7a58819-d9e5-4368-8aa2-09a64ceffd06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_393a233f-9944-469d-ac0e-51a0a32f6837" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased_393a233f-9944-469d-ac0e-51a0a32f6837" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_14df8df8-bfd7-4f18-af21-910a3f556a76" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants_14df8df8-bfd7-4f18-af21-910a3f556a76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_5f2c3109-0ee6-4335-87f8-60f32de24bd4" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions_5f2c3109-0ee6-4335-87f8-60f32de24bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_fd320de5-c8df-4058-bc0a-bf874c5a1e55" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_fd320de5-c8df-4058-bc0a-bf874c5a1e55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_1709c44f-d4d0-4116-a5ca-f2664b89a67d" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment_1709c44f-d4d0-4116-a5ca-f2664b89a67d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_8cb67c19-b90b-43b4-b73b-1557bde4f772" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalOther"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther_8cb67c19-b90b-43b4-b73b-1557bde4f772" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2ba94884-aaff-4ca0-b7a7-cc46c95e40cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_NetIncomeLoss_2ba94884-aaff-4ca0-b7a7-cc46c95e40cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharesOutstanding_deec1cba-a26a-477d-b3c6-76e319930590" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharesOutstanding"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_SharesOutstanding_deec1cba-a26a-477d-b3c6-76e319930590" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d80d5f88-93fb-4fb1-a675-c1eaee39db0e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_66d318b0-c8a5-4c73-85c9-15c0805021ed" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_d80d5f88-93fb-4fb1-a675-c1eaee39db0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWS"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_aad1f760-eb52-4b86-a66a-9636eef831fd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_aad1f760-eb52-4b86-a66a-9636eef831fd" xlink:to="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_25b0f748-e612-411e-a8b4-00b8bdea2959" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_c7715d0f-b785-40ef-9ee3-9c8b66566e47" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_c7715d0f-b785-40ef-9ee3-9c8b66566e47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseofCommonStockMember_9e4c2956-c328-4ffb-8f59-c5f173b188c2" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseofCommonStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_7688ae8a-f2d3-493a-a3e4-c1737fd66e9c" xlink:to="loc_lgnd_PurchaseofCommonStockMember_9e4c2956-c328-4ffb-8f59-c5f173b188c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_77a378c9-8fe6-46b7-b8c3-50bf4639cca5" xlink:to="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_d97ae0a4-9b8a-4125-9c16-bc271fe5d3a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_ProfitLoss_d97ae0a4-9b8a-4125-9c16-bc271fe5d3a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_833fbb53-8dc0-41c3-876f-1e60206d1ff3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax_833fbb53-8dc0-41c3-876f-1e60206d1ff3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_3854f92d-9ada-4085-8d1f-e9757ea55d9e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest_3854f92d-9ada-4085-8d1f-e9757ea55d9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_c335d135-af90-4c4e-a4f2-4676aca79612" xlink:href="lgnd-20181231.xsd#lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights_c335d135-af90-4c4e-a4f2-4676aca79612" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RealizedInvestmentGainsLosses_62f6a255-b7e3-45fd-96b5-ab79c5f04c35" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RealizedInvestmentGainsLosses"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_RealizedInvestmentGainsLosses_62f6a255-b7e3-45fd-96b5-ab79c5f04c35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_e2b4f818-f3c0-4e55-a63b-ab535617b511" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_e2b4f818-f3c0-4e55-a63b-ab535617b511" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromEquityMethodInvestments_bd7d22ee-16f4-4ee9-ba38-febd7acc598c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeLossFromEquityMethodInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_IncomeLossFromEquityMethodInvestments_bd7d22ee-16f4-4ee9-ba38-febd7acc598c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_8e28f8dd-fc5a-408d-8fc8-fd476396fa0b" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant_8e28f8dd-fc5a-408d-8fc8-fd476396fa0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f7a57af-d9ac-4921-a878-8db2f4292b32" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_2f7a57af-d9ac-4921-a878-8db2f4292b32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_42b2f593-8c18-4a43-8dbf-e9c981967448" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_42b2f593-8c18-4a43-8dbf-e9c981967448" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_924fcd89-8835-49ca-a377-985ef78a54bf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_ShareBasedCompensation_924fcd89-8835-49ca-a377-985ef78a54bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_214e6219-67f6-4fbc-b8a2-d3d16d9e2b82" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDeferredIncomeTaxes"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes_214e6219-67f6-4fbc-b8a2-d3d16d9e2b82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_a11fe548-7b6f-4152-85c3-b8fd65de7547" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement_a11fe548-7b6f-4152-85c3-b8fd65de7547" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_1ab29f5e-ff54-4827-bed2-de8e584540b6" xlink:href="lgnd-20181231.xsd#lgnd_ChangeInDerivativeAssetAndLiabilityFairValue"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_bce8f928-91fb-4b9e-baa0-e20ba8f7a339" xlink:to="loc_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue_1ab29f5e-ff54-4827-bed2-de8e584540b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_cdaa00d5-6762-48f8-b489-06e0c77d85ac" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_07e40a48-bcab-448a-aad2-58a44730de27" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_07e40a48-bcab-448a-aad2-58a44730de27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_343ea534-f838-4c52-9f3a-7c667fdfbbe2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_343ea534-f838-4c52-9f3a-7c667fdfbbe2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_2bf64ae2-3b13-4432-8b02-7d859f812990" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_2bf64ae2-3b13-4432-8b02-7d859f812990" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_682065d8-f55b-4b94-8948-83ab4294776c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_682065d8-f55b-4b94-8948-83ab4294776c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_231bb1c5-7880-41c3-b905-17ed18450eea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities_231bb1c5-7880-41c3-b905-17ed18450eea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseInContingentLiabilities_19aa579d-b3c9-461a-aeff-d40ca9e466ab" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseInContingentLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_lgnd_IncreaseDecreaseInContingentLiabilities_19aa579d-b3c9-461a-aeff-d40ca9e466ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4a5af3f7-2419-474c-baad-e3c36c67f485" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_4a5af3f7-2419-474c-baad-e3c36c67f485" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_05578e82-f256-401b-9dfb-f3a351007f96" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_f8083d59-06af-47fb-9852-81d57e421403" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_05578e82-f256-401b-9dfb-f3a351007f96" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseforCommercialLicenseRights_23fa1b8a-914d-47e8-aa08-00239783f836" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseforCommercialLicenseRights"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_lgnd_PurchaseforCommercialLicenseRights_23fa1b8a-914d-47e8-aa08-00239783f836" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a8c39e83-2b16-436b-8015-ab1ac585798a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireEquityMethodInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireEquityMethodInvestments_a8c39e83-2b16-436b-8015-ab1ac585798a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_9c702e74-7bcc-43d2-8c8d-444876e6048d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_9c702e74-7bcc-43d2-8c8d-444876e6048d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_1c35a2ba-f2c1-454f-aaf8-1b9ded9f670e" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity_1c35a2ba-f2c1-454f-aaf8-1b9ded9f670e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5c922e28-2068-44a6-9b43-26872051045c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_5c922e28-2068-44a6-9b43-26872051045c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_37f49a79-6276-478f-abe0-6faf0cc1ad3a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_37f49a79-6276-478f-abe0-6faf0cc1ad3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_ac020555-5f9e-4ad9-9d9c-ceab0b2fdf09" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromSaleOfShortTermInvestments"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromSaleOfShortTermInvestments_ac020555-5f9e-4ad9-9d9c-ceab0b2fdf09" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_1104af8a-2c3c-4530-b349-63cff5dcde00" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_1104af8a-2c3c-4530-b349-63cff5dcde00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromLicenseFeesReceived_e5c216db-0c12-4029-9d06-10fc9db76d05" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromLicenseFeesReceived"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromLicenseFeesReceived_e5c216db-0c12-4029-9d06-10fc9db76d05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_73f1703c-e316-406f-b7ee-d0b2a2581fcc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_73f1703c-e316-406f-b7ee-d0b2a2581fcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8e59cc10-d6cc-415d-bbb9-62f6d3fa1d03" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_f5af6af6-61f5-40af-9507-26c503fdd46a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_8e59cc10-d6cc-415d-bbb9-62f6d3fa1d03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfLongTermDebt_da66aa69-b81f-4d47-98f9-dc1655a0d2ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RepaymentsOfLongTermDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_RepaymentsOfLongTermDebt_da66aa69-b81f-4d47-98f9-dc1655a0d2ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromNotesPayable_fdf3c997-d850-4e49-a168-53b673d56dde" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromNotesPayable"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromNotesPayable_fdf3c997-d850-4e49-a168-53b673d56dde" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDebtIssuanceCosts_390dd1c1-0dff-486a-8489-c3f6130db812" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsOfDebtIssuanceCosts"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsOfDebtIssuanceCosts_390dd1c1-0dff-486a-8489-c3f6130db812" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfWarrants_918b99f2-ac58-4e59-be2a-c30e4e0c5f8d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfWarrants"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfWarrants_918b99f2-ac58-4e59-be2a-c30e4e0c5f8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PurchaseOfConvertibleBondHedge_f1e25b4b-7fe2-4d9d-98ff-5a592bee2e45" xlink:href="lgnd-20181231.xsd#lgnd_PurchaseOfConvertibleBondHedge"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_lgnd_PurchaseOfConvertibleBondHedge_f1e25b4b-7fe2-4d9d-98ff-5a592bee2e45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromHedgeFinancingActivities_66e77b5e-6b00-4236-98ad-080cff541722" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromHedgeFinancingActivities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromHedgeFinancingActivities_66e77b5e-6b00-4236-98ad-080cff541722" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForHedgeFinancingActivities_bc03113b-db3c-4c90-b924-b79147b82d8c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForHedgeFinancingActivities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForHedgeFinancingActivities_bc03113b-db3c-4c90-b924-b79147b82d8c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_05389ad4-e28c-4448-8343-4421afdc9ae0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_05389ad4-e28c-4448-8343-4421afdc9ae0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_736c5daa-f23e-4cc9-a26f-28e111432f5e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_736c5daa-f23e-4cc9-a26f-28e111432f5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3128d0e2-a4f3-4702-98c2-392cbccd0b66" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_3128d0e2-a4f3-4702-98c2-392cbccd0b66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_da4c2a38-55ee-4a15-99cf-2593d73c8a1b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_da4c2a38-55ee-4a15-99cf-2593d73c8a1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_58979788-3edb-440d-8631-b892cf08c365" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHoldersFinancingActivity"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity_58979788-3edb-440d-8631-b892cf08c365" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fd39ef16-5921-4308-b48e-b099437cd8fe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_37862824-4257-4088-8f61-f9e4d0e9fd92" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fd39ef16-5921-4308-b48e-b099437cd8fe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0f681fe4-940c-40a5-b0e3-05056f36ce4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_0f681fe4-940c-40a5-b0e3-05056f36ce4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_71ea98b9-ad23-423a-be0f-1dff0866a13a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_71ea98b9-ad23-423a-be0f-1dff0866a13a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6a6877e3-c4bd-403c-b821-d5c50942b135" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_6a6877e3-c4bd-403c-b821-d5c50942b135" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ec3a1352-b48b-4ccb-8c8b-48bf5e30a881" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ec3a1352-b48b-4ccb-8c8b-48bf5e30a881" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_fbe54367-72ff-4044-8125-61b910319fd9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:to="loc_us-gaap_InterestPaidNet_fbe54367-72ff-4044-8125-61b910319fd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxesPaid_1695c83b-b5ed-4d87-8ba7-ddaf46627dd0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxesPaid"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_7f5c4a16-9442-4d12-b543-d5ab6bcee787" xlink:to="loc_us-gaap_IncomeTaxesPaid_1695c83b-b5ed-4d87-8ba7-ddaf46627dd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_94710e34-1944-436f-94d9-ba49c4834fc0" xlink:to="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3035566e-4b93-4161-81f6-90805ae7c153" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodValueAcquisitions"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueAcquisitions_3035566e-4b93-4161-81f6-90805ae7c153" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable_9cd2a4b9-5592-46b4-b27e-a26699a59bed" xlink:href="lgnd-20181231.xsd#lgnd_EquityReceivedinRepaymentofNoteReceivable"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_lgnd_EquityReceivedinRepaymentofNoteReceivable_9cd2a4b9-5592-46b4-b27e-a26699a59bed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedInventoryPurchases_c9543b9d-8c2b-4869-99f3-6563b8db7f85" xlink:href="lgnd-20181231.xsd#lgnd_AccruedInventoryPurchases"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_lgnd_AccruedInventoryPurchases_c9543b9d-8c2b-4869-99f3-6563b8db7f85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_f39825f8-4516-4d68-90fd-baa3aeb549d5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract_b25c6f78-7035-41e0-98ff-f4bbee61ba73" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_f39825f8-4516-4d68-90fd-baa3aeb549d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_46c9f04a-0e20-46a7-adfa-dc355619925f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock_613f7fbb-5075-4625-95cc-cfd35400cc7f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_46c9f04a-0e20-46a7-adfa-dc355619925f" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock_613f7fbb-5075-4625-95cc-cfd35400cc7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConsolidationPolicyTextBlock_d4926b13-820a-41d0-8b9d-30b0f40e8698" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConsolidationPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ConsolidationPolicyTextBlock_d4926b13-820a-41d0-8b9d-30b0f40e8698" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_6ffefcc6-5d05-4ede-9e18-b9511cc3a923" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_6ffefcc6-5d05-4ede-9e18-b9511cc3a923" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_7465bf53-9c67-45a8-88e3-94999de8fbfa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PriorPeriodReclassificationAdjustmentDescription"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_PriorPeriodReclassificationAdjustmentDescription_7465bf53-9c67-45a8-88e3-94999de8fbfa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_0a746bf4-248c-4443-a40e-859df73e72c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_UseOfEstimates_0a746bf4-248c-4443-a40e-859df73e72c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_e886bd2b-d52f-4330-b749-ff988b116d29" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_e886bd2b-d52f-4330-b749-ff988b116d29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock_b917a343-07cf-4ecd-999c-3bea11df5fdd" xlink:href="lgnd-20181231.xsd#lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock_b917a343-07cf-4ecd-999c-3bea11df5fdd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock_b1c41f90-3696-4ed4-a2f4-ca11864ffe37" xlink:href="lgnd-20181231.xsd#lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock_b1c41f90-3696-4ed4-a2f4-ca11864ffe37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryPolicyTextBlock_3a2e92f9-7cf9-4c19-bc5e-09b5b0f8299a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryPolicyTextBlock"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_InventoryPolicyTextBlock_3a2e92f9-7cf9-4c19-bc5e-09b5b0f8299a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_3d5af742-0300-44be-a4c8-360c060a9830" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentPolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock_3d5af742-0300-44be-a4c8-360c060a9830" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_2d30f2b9-9e2f-4efa-a129-ca9fb3f6a4c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsPolicy"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_BusinessCombinationsPolicy_2d30f2b9-9e2f-4efa-a129-ca9fb3f6a4c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_67569ab2-7fc5-428d-b318-eb824065f3e4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy_67569ab2-7fc5-428d-b318-eb824065f3e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CommercialLicenseRightsPolicyTextBlock_365e50a2-5679-4181-9403-5130e55e48e5" xlink:href="lgnd-20181231.xsd#lgnd_CommercialLicenseRightsPolicyTextBlock"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_lgnd_CommercialLicenseRightsPolicyTextBlock_365e50a2-5679-4181-9403-5130e55e48e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_509e9df5-bc3e-4ea5-8f6d-1fb194f97959" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerPolicyTextBlock"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock_509e9df5-bc3e-4ea5-8f6d-1fb194f97959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock_4790b0a7-64c7-4d4e-8be3-844a1e483794" xlink:href="lgnd-20181231.xsd#lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock_4790b0a7-64c7-4d4e-8be3-844a1e483794" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_c810d1ad-b781-4b4a-b33b-c5e8538e7e69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpensePolicy"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpensePolicy_c810d1ad-b781-4b4a-b33b-c5e8538e7e69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_0afaaa46-2a26-4652-9335-9943f45fe695" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_0afaaa46-2a26-4652-9335-9943f45fe695" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxPolicyTextBlock_a504c7d6-9276-4dad-b57c-a9045df30243" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxPolicyTextBlock"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_IncomeTaxPolicyTextBlock_a504c7d6-9276-4dad-b57c-a9045df30243" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock_7d55658d-1efa-47e4-85d6-24351fa86a9f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationsPolicyTextBlock"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_DiscontinuedOperationsPolicyTextBlock_7d55658d-1efa-47e4-85d6-24351fa86a9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_1a465222-0db3-4157-8ad9-d25d1aa4e978" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_1a465222-0db3-4157-8ad9-d25d1aa4e978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_b9b45dd1-c4b6-467f-b923-672f989db375" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ComprehensiveIncomePolicyPolicyTextBlock"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock_b9b45dd1-c4b6-467f-b923-672f989db375" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_6752c267-aa14-40ab-8c10-3575794e0a2d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock_6752c267-aa14-40ab-8c10-3575794e0a2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_632c7ee4-7079-4704-acd7-48fef132e441" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_dfd0c9b7-3348-432c-9ab0-f70069d768d7" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_632c7ee4-7079-4704-acd7-48fef132e441" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_39eeb147-3200-476e-8111-af8d1f5bf2fd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:to="loc_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock_39eeb147-3200-476e-8111-af8d1f5bf2fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock_7df1da2e-7d7f-4db2-810a-1386fbf55003" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofCommercialLicenseRightsTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:to="loc_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock_7df1da2e-7d7f-4db2-810a-1386fbf55003" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_1c8e9130-1482-4bb6-b22e-efa89c3fe0ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:to="loc_us-gaap_DisaggregationOfRevenueTableTextBlock_1c8e9130-1482-4bb6-b22e-efa89c3fe0ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_d1394d71-6e6b-49b3-b06d-ca089a7c7d0a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDerivativeInstrumentsTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:to="loc_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock_d1394d71-6e6b-49b3-b06d-ca089a7c7d0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_6d21a05e-3b2a-404d-a990-16fbe867ae11" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_8f0dae3d-0bbe-4496-8ebe-2ef9a0570ebb" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_6d21a05e-3b2a-404d-a990-16fbe867ae11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ab1bab1d-1e04-4097-af77-e78c50c15e9f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_ab1bab1d-1e04-4097-af77-e78c50c15e9f" xlink:to="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_a335052e-cedc-4d34-8949-1a142151b3e6" xlink:to="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_d7c2757b-99a8-40e5-aad7-7772836d6b04" xlink:to="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyPromactaMember_1345cbe1-f8fc-482d-bfbc-d6e030676ac5" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyPromactaMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyPromactaMember_1345cbe1-f8fc-482d-bfbc-d6e030676ac5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyKyprolisMember_f91eabb1-2b9e-49dd-b8c5-d1f0e3fc04a9" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyKyprolisMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyKyprolisMember_f91eabb1-2b9e-49dd-b8c5-d1f0e3fc04a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyEvomelaMember_9674d3ae-3e07-4cd4-a642-a1e607c65830" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyEvomelaMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyEvomelaMember_9674d3ae-3e07-4cd4-a642-a1e607c65830" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyOtherMember_5400b880-7b44-4762-aa5b-4f2993439a0b" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyOtherMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RoyaltyMember_6b04628e-eb06-4784-90ee-be7dd01d0ec1" xlink:to="loc_lgnd_RoyaltyOtherMember_5400b880-7b44-4762-aa5b-4f2993439a0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:href="https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_0b964d13-4d40-4a35-a50b-599acdd93b57" xlink:to="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_8c00f435-8afa-4895-a640-06b66228d77d" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_29fb9ecd-d08a-4b55-81bd-c0d892191960" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_8c00f435-8afa-4895-a640-06b66228d77d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TitleOfIndividualWithRelationshipToEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TitleOfIndividualAxis_ea6d8c5b-4b2e-4ce3-a582-2929e48cced1" xlink:to="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DirectorMember_2cadb826-93e5-4ce4-a07a-e2f876ef9907" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DirectorMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TitleOfIndividualWithRelationshipToEntityDomain_01f223e6-7e1b-4323-add6-d88742f12cf7" xlink:to="loc_us-gaap_DirectorMember_2cadb826-93e5-4ce4-a07a-e2f876ef9907" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6c47967b-c984-4a26-b1ad-7169f6d101dd" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_fd10eae2-508c-4502-852f-021124c3c344" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_074b1df1-421e-4ee6-97e8-ae3e97b3b9b7" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_fd10eae2-508c-4502-852f-021124c3c344" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis_18eeb0fe-385d-4947-a6e0-02bcd1bc857a" xlink:to="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_29965567-c702-4c7e-8ade-b4ea54d8a865" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:to="loc_us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member_29965567-c702-4c7e-8ade-b4ea54d8a865" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_57b87a1b-59ae-4f91-84bd-e0272698e2a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain_bd87a862-cb11-46e4-b77d-59ee73cc5d27" xlink:to="loc_us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member_57b87a1b-59ae-4f91-84bd-e0272698e2a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_f99c2d4f-a5c0-4de5-a41e-7a6a1d964457" xlink:to="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_f55dc4e3-6d17-483e-a884-25966ca78438" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:to="loc_us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember_f55dc4e3-6d17-483e-a884-25966ca78438" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_131947d0-04e8-4881-9a5f-0f60358fe544" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_28e4493a-e95c-4a74-b341-2713fb86ec1b" xlink:to="loc_us-gaap_RetainedEarningsMember_131947d0-04e8-4881-9a5f-0f60358fe544" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsForNewAccountingPronouncementsAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TypeOfAdoptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis_401d13e1-d98a-4041-b0db-f410d880290b" xlink:to="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201609Member_64e77efa-098f-406f-8262-969d48a7ffc7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201609Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201609Member_64e77efa-098f-406f-8262-969d48a7ffc7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201409Member_7dfd35ae-3b81-4617-b3fb-0497b31ff8f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201409Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201409Member_7dfd35ae-3b81-4617-b3fb-0497b31ff8f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201601Member_abaf188e-a238-4837-bc78-ed2d7999dada" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201601Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201601Member_abaf188e-a238-4837-bc78-ed2d7999dada" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingStandardsUpdate201615Member_d55ff6e9-682a-41ad-826c-c05ba3de767c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccountingStandardsUpdate201615Member"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfAdoptionMember_ea936aef-c63f-47d2-8090-5dba46a54572" xlink:to="loc_us-gaap_AccountingStandardsUpdate201615Member_d55ff6e9-682a-41ad-826c-c05ba3de767c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_aed705e8-9366-47fc-82c4-0175d0290ce7" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_63a0c148-5558-4d0a-89a8-3b7ac017d3ac" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_63a0c148-5558-4d0a-89a8-3b7ac017d3ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_79ece950-870c-4737-a3cd-81903a15e3fb" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_60a2f14c-8492-47ce-9a15-0cc75da69130" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_79ece950-870c-4737-a3cd-81903a15e3fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_b3281673-4f60-4335-b2b7-a546151627c0" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_6dc9b4c1-e138-4d56-82ce-f439da1daa30" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_cc9538a3-4b5f-4991-8345-d9129ec21bdf" xlink:to="loc_us-gaap_SeniorNotesMember_6dc9b4c1-e138-4d56-82ce-f439da1daa30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_bcc5ea99-f65c-4e71-9443-f716c76a27f5" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_6b66cfb8-6617-487b-82b8-08c2f03b3f2d" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_6b66cfb8-6617-487b-82b8-08c2f03b3f2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoMember_29c5e06b-ce2f-4fe9-8b3a-6422851f7c57" xlink:href="lgnd-20181231.xsd#lgnd_AziyoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_AziyoMember_29c5e06b-ce2f-4fe9-8b3a-6422851f7c57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorMatrixMember_fed23aa7-b02c-46f6-87fa-5e9ca17fb7f4" xlink:href="lgnd-20181231.xsd#lgnd_CorMatrixMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_fef2e1ff-ec30-42a7-a4aa-7c89dac935e0" xlink:to="loc_lgnd_CorMatrixMember_fed23aa7-b02c-46f6-87fa-5e9ca17fb7f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_2b2971a3-101e-4072-b236-19c6c89f8ee8" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RoyaltyAgreementsMember_0ea7d3b6-f01f-40ef-ac64-d0cba36e3d04" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RoyaltyAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:to="loc_us-gaap_RoyaltyAgreementsMember_0ea7d3b6-f01f-40ef-ac64-d0cba36e3d04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_e12eced0-48ed-4e81-9b24-d8137960d242" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_b738463a-a043-4bd9-8522-2288f9790ef7" xlink:to="loc_us-gaap_LicensingAgreementsMember_e12eced0-48ed-4e81-9b24-d8137960d242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_b19f29bc-0532-4ddf-9921-ce66688ada5b" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_3bd38d7a-689a-47f3-8039-77f74fe76d5c" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:to="loc_lgnd_CrystalMember_3bd38d7a-689a-47f3-8039-77f74fe76d5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MetabasisTherapeuticsMember_0025baea-d8c5-4c62-a53d-a810a969146a" xlink:href="lgnd-20181231.xsd#lgnd_MetabasisTherapeuticsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_6f8a190f-449d-48b3-96fe-8d15a3825cbd" xlink:to="loc_lgnd_MetabasisTherapeuticsMember_0025baea-d8c5-4c62-a53d-a810a969146a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_a92cff51-5a8f-4aa8-a3da-39c0a0c0b5f0" xlink:to="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_4cc14076-fe0a-4377-b21d-d524bdfe3ca2" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:to="loc_srt_MinimumMember_4cc14076-fe0a-4377-b21d-d524bdfe3ca2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_56e0e662-2130-46c8-9b94-aeff88a020b6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_12f5e4ab-6619-4975-86f0-6597b75af8e3" xlink:to="loc_srt_MaximumMember_56e0e662-2130-46c8-9b94-aeff88a020b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_6fc9ad50-ab54-4713-a392-9fb9bf078641" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_84c5f208-fbfb-4a2a-95f8-8c2ccfefd73b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b9306ce0-ecde-4fb2-afa3-a05ee533bf26" xlink:to="loc_us-gaap_EmployeeStockOptionMember_84c5f208-fbfb-4a2a-95f8-8c2ccfefd73b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingAxis"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VestingDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingAxis_34bd3196-babc-4ec7-8961-bccc662b1cee" xlink:to="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodOneMember_3386c510-1a13-4d83-85d9-90d9fb795efc" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:to="loc_lgnd_VestingPeriodOneMember_3386c510-1a13-4d83-85d9-90d9fb795efc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VestingPeriodTwoMember_2137976b-5fb6-401a-8323-ff7432a76a0f" xlink:href="lgnd-20181231.xsd#lgnd_VestingPeriodTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VestingDomain_56f9d279-4d3e-499c-aa86-8c464b6fd1c1" xlink:to="loc_lgnd_VestingPeriodTwoMember_2137976b-5fb6-401a-8323-ff7432a76a0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_abaaad0e-9d04-4ca3-b7ca-ec4f9c0d8739" xlink:to="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_ad474feb-9a83-4981-a8a8-56c0feead349" xlink:href="lgnd-20181231.xsd#lgnd_TwoThousandTwoStockIncentivePlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_2ba0e68e-c685-4a1e-b594-0aa5acac1293" xlink:to="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_ad474feb-9a83-4981-a8a8-56c0feead349" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:href="lgnd-20181231.xsd#lgnd_BasisOfPresentationLineItems"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationTable_dafeed63-f5a6-46bc-877e-7ebb3c822fe9" xlink:to="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrealizedGainLossOnInvestments_17e3ba77-f8bf-48dc-b42c-3fd75a5acd36" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrealizedGainLossOnInvestments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_UnrealizedGainLossOnInvestments_17e3ba77-f8bf-48dc-b42c-3fd75a5acd36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_99849427-f664-42fb-ba20-c4386144b4cf" xlink:href="lgnd-20181231.xsd#lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum_99849427-f664-42fb-ba20-c4386144b4cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_1e047b12-b91e-4df0-bba1-f7a1e63a059c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InventoryWriteDown"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_InventoryWriteDown_1e047b12-b91e-4df0-bba1-f7a1e63a059c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3ed1d4d8-e94d-442a-be17-d851f933955b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_3ed1d4d8-e94d-442a-be17-d851f933955b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_c3014c99-c2e5-491f-8134-f50b58c95032" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_c3014c99-c2e5-491f-8134-f50b58c95032" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberOfContingentValueRightsIssued_9016522d-6251-4c5e-8401-eb5fcf059116" xlink:href="lgnd-20181231.xsd#lgnd_NumberOfContingentValueRightsIssued"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_NumberOfContingentValueRightsIssued_9016522d-6251-4c5e-8401-eb5fcf059116" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRoyaltiesReceived_43c882e9-f5ad-4704-8090-46ca567ed755" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromRoyaltiesReceived"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ProceedsFromRoyaltiesReceived_43c882e9-f5ad-4704-8090-46ca567ed755" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ProductRoyaltyPercentage_4fb9a216-ec6e-4fb2-a0cf-ad3b3cd307d5" xlink:href="lgnd-20181231.xsd#lgnd_ProductRoyaltyPercentage"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ProductRoyaltyPercentage_4fb9a216-ec6e-4fb2-a0cf-ad3b3cd307d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OwnershipInEntityByDirectorPercentage_6c1d9392-94f3-4a2f-98be-23af8b2b8508" xlink:href="lgnd-20181231.xsd#lgnd_OwnershipInEntityByDirectorPercentage"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_OwnershipInEntityByDirectorPercentage_6c1d9392-94f3-4a2f-98be-23af8b2b8508" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_8cb23e45-545a-425b-bef5-f4c18bc9f868" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones_8cb23e45-545a-425b-bef5-f4c18bc9f868" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RoyaltyAgreementExpirationPeriod_17490822-9a05-4333-85bf-c67ea8457594" xlink:href="lgnd-20181231.xsd#lgnd_RoyaltyAgreementExpirationPeriod"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RoyaltyAgreementExpirationPeriod_17490822-9a05-4333-85bf-c67ea8457594" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_1ab5cce9-91ec-42a9-b84f-baf0257bb65d" xlink:href="lgnd-20181231.xsd#lgnd_ForecastedCashFlowsEffectiveInterestRatePercent"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent_1ab5cce9-91ec-42a9-b84f-baf0257bb65d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2588247d-7f28-484a-b514-f0cff0b2b0d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_2588247d-7f28-484a-b514-f0cff0b2b0d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_5fedad05-e946-4f13-8c4a-b2fa1ffd7a69" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived_5fedad05-e946-4f13-8c4a-b2fa1ffd7a69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_207ac468-40db-4a95-bdf0-6d39226555f5" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived_207ac468-40db-4a95-bdf0-6d39226555f5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_5d7f036e-40f3-4ab1-b25f-911ab54139e2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerLiabilityRevenueRecognized"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityRevenueRecognized_5d7f036e-40f3-4ab1-b25f-911ab54139e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e83973b4-c6ee-4f33-87ef-c18a7a0c01dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_e83973b4-c6ee-4f33-87ef-c18a7a0c01dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2c4af02b-8f7c-4f2a-852b-023ee64b2431" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetIncomeLoss_2c4af02b-8f7c-4f2a-852b-023ee64b2431" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_13c9d5d7-56da-4642-a359-d0788dbdb8d2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_EarningsPerShareDiluted_13c9d5d7-56da-4642-a359-d0788dbdb8d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationAbstract"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput_0e1e2d57-2fe0-4d45-b60c-e646b967fb94" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesFvNiMeasurementInput"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_EquitySecuritiesFvNiMeasurementInput_0e1e2d57-2fe0-4d45-b60c-e646b967fb94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockDividendsPerShareDeclared_6bb2a7c6-bc46-494e-ba10-ae065fb5191e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommonStockDividendsPerShareDeclared"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_CommonStockDividendsPerShareDeclared_6bb2a7c6-bc46-494e-ba10-ae065fb5191e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_86bfb56e-d4e3-4278-ab87-30ff85821e3e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_86bfb56e-d4e3-4278-ab87-30ff85821e3e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_0015afb1-d2f3-4ffb-91cb-c4663c3d1f33" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage_0015afb1-d2f3-4ffb-91cb-c4663c3d1f33" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_4756940c-8021-4016-85b2-bb885562a9c3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationAbstract_7a9a57ba-1378-4691-9139-3076464f6c46" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_4756940c-8021-4016-85b2-bb885562a9c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_dfcdfa17-30ea-415f-a8ca-74d8f83be897" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_dfcdfa17-30ea-415f-a8ca-74d8f83be897" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_70b1aa65-c69b-4eb5-8f07-dddd4262b874" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation_70b1aa65-c69b-4eb5-8f07-dddd4262b874" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_8651c0c3-4376-455d-b15c-facee87fb43d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_8651c0c3-4376-455d-b15c-facee87fb43d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c2961147-03b6-46f1-8206-3fc6455fa8b3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c2961147-03b6-46f1-8206-3fc6455fa8b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_a74d8afb-6e5a-43ce-9cf0-543e599c97e2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_a74d8afb-6e5a-43ce-9cf0-543e599c97e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_eda4f340-1732-48a0-9f33-e319d7892aaf" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdBusinessDaysforRepaymentofPrincipal"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal_eda4f340-1732-48a0-9f33-e319d7892aaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_25012d8b-65cd-409e-90bb-6a1e7dfce14e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_25012d8b-65cd-409e-90bb-6a1e7dfce14e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_4afe05db-a47a-4f92-99a4-397d18d11e99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption_4afe05db-a47a-4f92-99a4-397d18d11e99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_78de276e-96a3-429a-9db3-3837433d3b51" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_78de276e-96a3-429a-9db3-3837433d3b51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8246f845-9782-4e75-ad46-1fd7ee1073e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8246f845-9782-4e75-ad46-1fd7ee1073e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe113c30-04e5-4277-8290-889402d9c7c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_BasisOfPresentationLineItems_96ee2801-595f-4b42-8a0f-f42800a4dcc2" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_fe113c30-04e5-4277-8290-889402d9c7c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1868a8e3-16f4-4fb8-8250-8d174452a8de" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1868a8e3-16f4-4fb8-8250-8d174452a8de" xlink:to="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_3a72fd73-1821-4caa-a38b-5bba94e42254" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerConcentrationRiskMember_4745ad59-b978-4279-9d4e-e73696910fb8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerConcentrationRiskMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_3ac2adfd-4b46-4295-b572-3ca9e859e3f0" xlink:to="loc_us-gaap_CustomerConcentrationRiskMember_4745ad59-b978-4279-9d4e-e73696910fb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_a214cab9-703d-44c2-8fbb-826cc26f003d" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_4ae39076-b68a-4c5d-a880-037c4ec1ce18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_2adf1586-0f72-4c80-9d45-17b5d9257749" xlink:to="loc_us-gaap_SalesRevenueNetMember_4ae39076-b68a-4c5d-a880-037c4ec1ce18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MajorCustomersAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_NameOfMajorCustomerDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_MajorCustomersAxis_5a87b9d8-f7bf-4256-9fab-b09212f85835" xlink:to="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerAMember_67fc7f0f-1457-4da5-aaf6-36bac9e23ffe" xlink:href="lgnd-20181231.xsd#lgnd_PartnerAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerAMember_67fc7f0f-1457-4da5-aaf6-36bac9e23ffe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerBMember_334e1b5a-2dab-471f-a0ad-e6a0fab11c8b" xlink:href="lgnd-20181231.xsd#lgnd_PartnerBMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerBMember_334e1b5a-2dab-471f-a0ad-e6a0fab11c8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PartnerCMember_ff52b44b-a170-49a5-a783-8f79f74122f1" xlink:href="lgnd-20181231.xsd#lgnd_PartnerCMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_NameOfMajorCustomerDomain_e2b06cb8-c54a-4e0b-a9a8-0e6c6eb255f7" xlink:to="loc_lgnd_PartnerCMember_ff52b44b-a170-49a5-a783-8f79f74122f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EntityWideRevenueMajorCustomerLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable_c789acfc-15ce-45ab-b62e-89747d08a870" xlink:to="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_fe6dac08-39f8-423f-9a53-3883b78ddef2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EntityWideRevenueMajorCustomerLineItems_ac8f0755-12be-4e96-92f3-e1168f66390a" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_fe6dac08-39f8-423f-9a53-3883b78ddef2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4d984524-1ef7-4a53-8b93-650af47dc3a6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_4d984524-1ef7-4a53-8b93-650af47dc3a6" xlink:to="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:to="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_7852063b-9377-4d40-8498-10bc01e1c827" xlink:to="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MaterialSalesCaptisolMember_8fe59f48-aa99-4387-a95f-28cf41fd7433" xlink:href="lgnd-20181231.xsd#lgnd_MaterialSalesCaptisolMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:to="loc_lgnd_MaterialSalesCaptisolMember_8fe59f48-aa99-4387-a95f-28cf41fd7433" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesandProductOtherMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_7855a39b-e9eb-498c-8a65-d2092441abe0" xlink:to="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMember_4b710680-2c65-4cfc-949d-bacde2acbe60" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_LicenseFeesMember_4b710680-2c65-4cfc-949d-bacde2acbe60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestoneMember_4cd6320e-fac5-4ff1-9dfb-0b6df2a036c2" xlink:href="lgnd-20181231.xsd#lgnd_MilestoneMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_MilestoneMember_4cd6320e-fac5-4ff1-9dfb-0b6df2a036c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_abfa8191-cda0-4ee7-a3c0-b75128e2eea7" xlink:href="lgnd-20181231.xsd#lgnd_LicenseFeesMilestonesAndOtherProductOtherMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_LicenseFeesMilestonesandProductOtherMember_6e6b0c40-19cc-498b-9563-a087de815b15" xlink:to="loc_lgnd_LicenseFeesMilestonesAndOtherProductOtherMember_abfa8191-cda0-4ee7-a3c0-b75128e2eea7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisaggregationOfRevenueLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueTable_fb99d179-4973-4a69-8637-dd8cd595fe65" xlink:to="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7dad168d-e29c-4388-947b-9247104558e8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisaggregationOfRevenueLineItems_807ba726-4593-4f24-b647-8ff541a946a0" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_7dad168d-e29c-4388-947b-9247104558e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_5d20321e-4556-4f62-807e-a55926503cdb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_5d20321e-4556-4f62-807e-a55926503cdb" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_0ae852b0-5bdb-4bf4-b9ab-0e26e77b286e" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LicensingAgreementsMember_5d8c9a81-9a85-42dc-98f6-c1771ab2b5d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LicensingAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_1f8e6186-c552-44d4-9c86-5d4a569302d1" xlink:to="loc_us-gaap_LicensingAgreementsMember_5d8c9a81-9a85-42dc-98f6-c1771ab2b5d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:to="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_12a941bf-0313-4bbc-b8ee-43b4e70f04bd" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AziyoandCorMatrixMember_6b422018-31f1-46cc-a980-f809720f4d9c" xlink:href="lgnd-20181231.xsd#lgnd_AziyoandCorMatrixMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_AziyoandCorMatrixMember_6b422018-31f1-46cc-a980-f809720f4d9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PalvellaTherapeuticsIncMember_05683a62-506e-41f8-9eac-cfe8ca11e545" xlink:href="lgnd-20181231.xsd#lgnd_PalvellaTherapeuticsIncMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_PalvellaTherapeuticsIncMember_05683a62-506e-41f8-9eac-cfe8ca11e545" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_SelexisMember_8182dacd-65c4-4df3-92da-63faffdb2ea5" xlink:href="lgnd-20181231.xsd#lgnd_SelexisMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_c0e0eabc-c1b2-49e4-aedc-98eeb40d7850" xlink:to="loc_lgnd_SelexisMember_8182dacd-65c4-4df3-92da-63faffdb2ea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_ab2d9c0f-0903-4057-abef-be9676188500" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5cd1ae31-8c1b-4e6a-bd54-509b0a811b40" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_5cd1ae31-8c1b-4e6a-bd54-509b0a811b40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eb13cdc9-662c-4ae4-8a9d-1b2c7a6cb0ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_eb13cdc9-662c-4ae4-8a9d-1b2c7a6cb0ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0d5c3457-0218-4cd6-a9df-c660589a4752" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_97267544-faf9-428a-bb70-48f57ddd5bf4" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsNet_0d5c3457-0218-4cd6-a9df-c660589a4752" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3a563ebb-5abd-452c-9aca-c8cb5bffdd30" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3a563ebb-5abd-452c-9aca-c8cb5bffdd30" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_fb978042-0608-40a3-88ce-aa421e4d7226" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_3144b40c-d8a9-43fc-8feb-8d8b44cc9c97" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_01c247da-db8b-43e4-974b-57e93cbfe648" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_3144b40c-d8a9-43fc-8feb-8d8b44cc9c97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_966268d2-f6f0-42af-a7cb-9a655a308fc0" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_c12e823d-affe-4d4f-b446-25be6cd3f84f" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_c12e823d-affe-4d4f-b446-25be6cd3f84f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_ee6001ed-fc8b-4e58-93cd-0e6b10cfb012" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_f1091c74-ab09-4f5a-9d31-dcebef7b0830" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_ee6001ed-fc8b-4e58-93cd-0e6b10cfb012" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_6b759b47-a372-4dcb-ab23-4f06d904c99c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e92b6f52-117a-402e-b711-53e0e4e8ab9f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_e92b6f52-117a-402e-b711-53e0e4e8ab9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_b85e5dc7-f652-477b-89a1-da683cb8d0ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_b85e5dc7-f652-477b-89a1-da683cb8d0ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_aea87594-d054-43c5-8d56-7e9fe9d39009" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_aea87594-d054-43c5-8d56-7e9fe9d39009" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputCouponRateMember_cc814f61-6b47-4344-bcae-11f77117d171" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputCouponRateMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_lgnd_MeasurementInputCouponRateMember_cc814f61-6b47-4344-bcae-11f77117d171" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MeasurementInputRemainingTermMember_9a03c75a-0e23-496c-abbc-80e6de3f5e61" xlink:href="lgnd-20181231.xsd#lgnd_MeasurementInputRemainingTermMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_aee81340-d4d2-4a56-9540-7ad96ef760b9" xlink:to="loc_lgnd_MeasurementInputRemainingTermMember_9a03c75a-0e23-496c-abbc-80e6de3f5e61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_07d4d718-41ca-4f8d-8b8e-d590eb30ed37" xlink:to="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_0beb4db4-d8da-4f0c-a200-2691e9ac282a" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:to="loc_srt_MinimumMember_0beb4db4-d8da-4f0c-a200-2691e9ac282a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_dcbbfc81-1e76-4ed7-bf70-c697ee0f13a6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_e44c9ed6-d890-41d6-9aaf-0b058473ce86" xlink:to="loc_srt_MaximumMember_dcbbfc81-1e76-4ed7-bf70-c697ee0f13a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable_a52de9d9-e3c2-4788-959f-2f648cf42049" xlink:to="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_f283d4e7-2849-49fc-820c-dcc816d403c9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_us-gaap_SharePrice_f283d4e7-2849-49fc-820c-dcc816d403c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceofConvertibleBondHedge_0540646c-1957-46d3-ba18-389e2d4fcad5" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceofConvertibleBondHedge"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_lgnd_ExercisePriceofConvertibleBondHedge_0540646c-1957-46d3-ba18-389e2d4fcad5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_invest_InvestmentWarrantsExercisePrice_3f91abb1-ae99-4aca-934e-44fc98ebb7d2" xlink:href="http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd#invest_InvestmentWarrantsExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_invest_InvestmentWarrantsExercisePrice_3f91abb1-ae99-4aca-934e-44fc98ebb7d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeLiabilityMeasurementInput_bc7ce23f-1829-4f95-841b-98f5f41c60ec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeLiabilityMeasurementInput"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems_edf8f4c1-c7a3-410f-b9f4-e9eba2bd8848" xlink:to="loc_us-gaap_DerivativeLiabilityMeasurementInput_bc7ce23f-1829-4f95-841b-98f5f41c60ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e1478d02-6f6a-4a50-b5e2-23de6a7b3441" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b564f8bf-219d-438c-bb3a-d1498e8303e9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e1478d02-6f6a-4a50-b5e2-23de6a7b3441" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_b564f8bf-219d-438c-bb3a-d1498e8303e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAndDilutedAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e1478d02-6f6a-4a50-b5e2-23de6a7b3441" xlink:to="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_88316e2d-e037-4f0e-9d7a-0cf242925afd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesRestrictedStock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesRestrictedStock_88316e2d-e037-4f0e-9d7a-0cf242925afd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_505d4404-5bc3-4f62-b227-ff27d9cd0c40" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_505d4404-5bc3-4f62-b227-ff27d9cd0c40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_9519d1ce-dad5-4b91-8264-1857afa2f7a2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants_9519d1ce-dad5-4b91-8264-1857afa2f7a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_645fb928-1089-4ada-9125-cc644bb09048" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities_645fb928-1089-4ada-9125-cc644bb09048" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e62bec9d-1151-4b7a-9a63-49ca4e3ebd55" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAndDilutedAbstract_5df925b2-9e4d-42dd-9a95-89eff33fefac" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_e62bec9d-1151-4b7a-9a63-49ca4e3ebd55" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_732e925e-0cd2-4d70-b1d3-f71a3310fc07" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_e1478d02-6f6a-4a50-b5e2-23de6a7b3441" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_732e925e-0cd2-4d70-b1d3-f71a3310fc07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinViking" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinViking"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/InvestmentinViking" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d8e3cb97-415a-4510-a88a-20a78396d77a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_2a4698fe-8f7f-4c29-9744-37f6e4103fcd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_d8e3cb97-415a-4510-a88a-20a78396d77a" xlink:to="loc_us-gaap_VariableInterestEntityDisclosureTextBlock_2a4698fe-8f7f-4c29-9744-37f6e4103fcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#InvestmentinVikingNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/InvestmentinVikingNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_fc000ee5-d118-4f4c-a20a-f8b109b45eed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfVariableInterestEntitiesTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_fc000ee5-d118-4f4c-a20a-f8b109b45eed" xlink:to="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_OwnershipDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipAxis_deb3a714-8ac2-4b2e-accf-ce9ff9b76825" xlink:to="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_73bee3ba-207e-482d-9b30-ca9cdf60c331" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_OwnershipDomain_282ba327-872c-424a-b4f6-79b9cc6028ae" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_73bee3ba-207e-482d-9b30-ca9cdf60c331" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialInstrumentAxis_0f2c72f2-cf04-4079-b1ec-f91d2041630d" xlink:to="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_dc4c57cf-a19c-41c8-ada7-21c3bb46af6a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain_75e1ae1c-befa-4066-ac4f-7f13018563ae" xlink:to="loc_us-gaap_WarrantMember_dc4c57cf-a19c-41c8-ada7-21c3bb46af6a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_5318c741-75e6-409b-bad2-49030e70b509" xlink:to="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvesteeMember_4f859713-9f53-4103-91f8-fc585bb38578" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvesteeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_862002fe-0a20-4bc4-834a-f9a7518c404b" xlink:to="loc_us-gaap_EquityMethodInvesteeMember_4f859713-9f53-4103-91f8-fc585bb38578" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeInstrumentRiskAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeContractTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeInstrumentRiskAxis_ff3d984f-bcac-423b-9b3e-fe51391e98b7" xlink:to="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtMember_a114e9a7-6a95-4187-aa8e-6e82e6bb3761" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DerivativeContractTypeDomain_b568e885-25d5-4e15-93a0-a40c0ca954c7" xlink:to="loc_us-gaap_DebtMember_a114e9a7-6a95-4187-aa8e-6e82e6bb3761" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassificationOfVariableInterestEntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis_4e2f5ff2-0052-4487-8ddf-300837849571" xlink:to="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_76ec4009-a0e9-4d67-ba5e-9947ff2cc3cb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityPrimaryBeneficiaryMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassificationOfVariableInterestEntityDomain_b551d273-2ddb-41a3-8ba5-53b4adaec351" xlink:to="loc_us-gaap_VariableInterestEntityPrimaryBeneficiaryMember_76ec4009-a0e9-4d67-ba5e-9947ff2cc3cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfVariableInterestEntitiesTable_638b7413-c93f-44cf-8b80-51eda2deb9f1" xlink:to="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_ebff165a-cb65-486c-9eab-9b4b8325efc6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest_ebff165a-cb65-486c-9eab-9b4b8325efc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_0e079d7d-9719-4c16-9472-4b202b66f4d6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityMethodInvestmentOwnershipPercentage"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_EquityMethodInvestmentOwnershipPercentage_0e079d7d-9719-4c16-9472-4b202b66f4d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment_080b07ed-b3e6-4f17-9f74-3fac6c9f84b5" xlink:href="lgnd-20181231.xsd#lgnd_IncreaseDecreaseinEquityMethodInvestment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_IncreaseDecreaseinEquityMethodInvestment_080b07ed-b3e6-4f17-9f74-3fac6c9f84b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_647f81a1-e67b-474f-bacd-23214bd36300" xlink:href="lgnd-20181231.xsd#lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded_647f81a1-e67b-474f-bacd-23214bd36300" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_5e315a2b-7343-4b23-8a15-e3100f0426aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount_5e315a2b-7343-4b23-8a15-e3100f0426aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent_fe6c9816-900d-47e4-a5c1-8a41a2ab11a2" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableAmountDueUponTriggeringEvent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_NoteReceivableAmountDueUponTriggeringEvent_fe6c9816-900d-47e4-a5c1-8a41a2ab11a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_4ebff050-c773-49a9-aa98-f3ed141e1978" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromCollectionOfNotesReceivable"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ProceedsFromCollectionOfNotesReceivable_4ebff050-c773-49a9-aa98-f3ed141e1978" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_292d838f-3768-4a57-9ca0-4e5396e71371" xlink:href="lgnd-20181231.xsd#lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement_292d838f-3768-4a57-9ca0-4e5396e71371" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent_b623402b-6e85-4226-a350-74517b73c4d6" xlink:href="lgnd-20181231.xsd#lgnd_NoteReceivableCashDueUponTriggeringEvent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_lgnd_NoteReceivableCashDueUponTriggeringEvent_b623402b-6e85-4226-a350-74517b73c4d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_72913aae-f0ba-4258-b047-a00963ff2b2e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1_72913aae-f0ba-4258-b047-a00963ff2b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_46c086c8-f7ff-44e1-88fc-9a22c6ffad79" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_46c086c8-f7ff-44e1-88fc-9a22c6ffad79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_c95ac271-0d16-467d-b561-a2b1f40bd0eb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_c95ac271-0d16-467d-b561-a2b1f40bd0eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_7539766a-c3dd-4811-b617-51f4e64a802e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueOptionChangesInFairValueGainLoss1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_FairValueOptionChangesInFairValueGainLoss1_7539766a-c3dd-4811-b617-51f4e64a802e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfInvestments_daea6522-68ce-4250-87f4-b3bb3e6cc5d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfInvestments"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableInterestEntityLineItems_9dd7187a-26b1-4f7d-bc98-df72ed0d4a0d" xlink:to="loc_us-gaap_ImpairmentOfInvestments_daea6522-68ce-4250-87f4-b3bb3e6cc5d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinations"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BusinessCombinations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_19fcaed2-eb0a-433f-b6c9-e1d67f856d6b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock_c06131ac-6838-4041-845b-6a5fa1a90be4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_19fcaed2-eb0a-433f-b6c9-e1d67f856d6b" xlink:to="loc_us-gaap_BusinessCombinationDisclosureTextBlock_c06131ac-6838-4041-845b-6a5fa1a90be4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_8826ad2e-03c1-4599-81b0-0727e2e859e3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_8826ad2e-03c1-4599-81b0-0727e2e859e3" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_fb45b788-a2cb-46ec-b277-d171163a6123" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_6b866e92-1169-4a5c-8ddc-56389d2446f3" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_VernalisMember_6b866e92-1169-4a5c-8ddc-56389d2446f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_9775e1c9-42f4-49d9-ac6d-7e1f6c05ebcf" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_CrystalMember_9775e1c9-42f4-49d9-ac6d-7e1f6c05ebcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_af7b5685-254f-4970-bf93-601fdf432dcd" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_2a6ab0f4-824e-48b3-be13-30b8de897586" xlink:to="loc_lgnd_OMTInc.Member_af7b5685-254f-4970-bf93-601fdf432dcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_41c1e991-c22f-449e-b3a2-e9ee177dd57d" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_9e42bdb2-2101-4dc3-ad7b-dfe4b9b8a7c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:to="loc_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock_9e42bdb2-2101-4dc3-ad7b-dfe4b9b8a7c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_d4d2c628-605f-4b01-933c-f3fc80c60259" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_04e4c29d-09ff-415e-9768-c47f7480ff64" xlink:to="loc_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock_d4d2c628-605f-4b01-933c-f3fc80c60259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_e78cd208-50db-45f5-9a97-3867c1c645b4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_e78cd208-50db-45f5-9a97-3867c1c645b4" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:href="lgnd-20181231.xsd#lgnd_VariableRateComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_VariableRateComponentAxis_48ae7e1e-e4bf-4e39-8f6f-599e1c57ea89" xlink:to="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_47584c46-3fb3-4253-bbcd-e08bd4849083" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:to="loc_lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember_47584c46-3fb3-4253-bbcd-e08bd4849083" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_706a1dc5-19cf-4d76-ae2b-98bbb5ea1314" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_VariableRateComponentDomain_5c1403b2-eef7-4a14-b57f-87b00c787216" xlink:to="loc_lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember_706a1dc5-19cf-4d76-ae2b-98bbb5ea1314" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_961f0264-51cd-44cb-b5a4-38df5ca0823a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DevelopedTechnologyRightsMember_e1421a56-3405-4640-a0b7-5a6dd74c4525" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DevelopedTechnologyRightsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_0a784ee8-9d2f-4061-a4bd-8ce8744b642f" xlink:to="loc_us-gaap_DevelopedTechnologyRightsMember_e1421a56-3405-4640-a0b7-5a6dd74c4525" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_9224a268-ac83-4ba7-8420-569790a6e553" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_5a7c5270-e85a-4c17-a448-32201e59964b" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_VernalisMember_5a7c5270-e85a-4c17-a448-32201e59964b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_7ba609f8-5d74-4b71-95fb-10f536a7cb24" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_CrystalMember_7ba609f8-5d74-4b71-95fb-10f536a7cb24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_67b8240e-8de6-4bb8-95c0-876891810e7f" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_ba41cb57-32ca-4c8b-b9c5-008e5fc904f0" xlink:to="loc_lgnd_OMTInc.Member_67b8240e-8de6-4bb8-95c0-876891810e7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_8ada11fb-dcdb-4f5a-b56e-5c4509b97f4a" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_fec43594-c726-499f-af4f-2ebf09e6af16" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_fec43594-c726-499f-af4f-2ebf09e6af16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_e5f67246-9959-4043-9105-58294ae97a47" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate_e5f67246-9959-4043-9105-58294ae97a47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WorkingCapitalAdjustment_61598e4f-41f5-4eaf-a64a-607b3964bfa3" xlink:href="lgnd-20181231.xsd#lgnd_WorkingCapitalAdjustment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_WorkingCapitalAdjustment_61598e4f-41f5-4eaf-a64a-607b3964bfa3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_d9940cba-85c6-4b81-8c56-d47adbdb3e70" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_d9940cba-85c6-4b81-8c56-d47adbdb3e70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_7d94d4a5-6cf3-48a0-92c5-37c6c139679b" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_7d94d4a5-6cf3-48a0-92c5-37c6c139679b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_38760605-a23d-4747-b3a2-9e0a7e796f8f" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_38760605-a23d-4747-b3a2-9e0a7e796f8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_NumberofCollaborationAgreements_16083860-4891-45c3-9e3e-28bd355b96ab" xlink:href="lgnd-20181231.xsd#lgnd_NumberofCollaborationAgreements"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_NumberofCollaborationAgreements_16083860-4891-45c3-9e3e-28bd355b96ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPayable_bbaf1926-3860-4a54-9d7d-62c79990f22f" xlink:href="lgnd-20181231.xsd#lgnd_CashPayable"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_CashPayable_bbaf1926-3860-4a54-9d7d-62c79990f22f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_0337453d-8a90-44a0-9acb-745213460c47" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_0337453d-8a90-44a0-9acb-745213460c47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_4194abb1-d89e-4f43-9d7c-6e256920d490" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate_4194abb1-d89e-4f43-9d7c-6e256920d490" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8bb88d5a-6c9b-4d50-b1fd-89d6005b9a81" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_8bb88d5a-6c9b-4d50-b1fd-89d6005b9a81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5288f2a0-bfb6-49d4-89d2-c6e599f90270" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_Goodwill_5288f2a0-bfb6-49d4-89d2-c6e599f90270" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_7eef172a-2d73-41b2-901f-d945cbb90c29" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_3589dbef-5d64-4647-a900-5b9e8d67986a" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferred1_7eef172a-2d73-41b2-901f-d945cbb90c29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_0777a7f6-b9bd-44ae-9ede-df408932f5e3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_fd970768-5f35-4f68-90ff-17f23523165d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_0777a7f6-b9bd-44ae-9ede-df408932f5e3" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_fd970768-5f35-4f68-90ff-17f23523165d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d12e7dfd-1611-464e-89dc-a678268c69ff" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VernalisMember_5b8a6e45-42c2-4a06-8400-a5e9a1306142" xlink:href="lgnd-20181231.xsd#lgnd_VernalisMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_VernalisMember_5b8a6e45-42c2-4a06-8400-a5e9a1306142" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_06e31e20-b721-4809-aa7e-1f4e7df7d31c" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_CrystalMember_06e31e20-b721-4809-aa7e-1f4e7df7d31c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_2e5f4302-5a49-4803-9a00-0ffb4ed13485" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_7e9e3926-e8e1-45a1-9e0e-cb824c438ba8" xlink:to="loc_lgnd_OMTInc.Member_2e5f4302-5a49-4803-9a00-0ffb4ed13485" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_904dd06c-90ed-4ca9-8b9f-d232c4b3b06e" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dd8938d4-b32b-4c79-8275-3ea47c9f774c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dd8938d4-b32b-4c79-8275-3ea47c9f774c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_3edc7602-1874-4dad-a4aa-1b6692dcc112" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash_3edc7602-1874-4dad-a4aa-1b6692dcc112" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_b2169e84-0902-4b47-bc58-96165a7229d9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_b2169e84-0902-4b47-bc58-96165a7229d9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_1afe9d91-bc6d-4001-b904-eed8aa4b72c1" xlink:href="lgnd-20181231.xsd#lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables_1afe9d91-bc6d-4001-b904-eed8aa4b72c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_9eb252ba-7641-41bd-9d7b-0f3c4dc4f92b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets_9eb252ba-7641-41bd-9d7b-0f3c4dc4f92b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_1ad1991e-588d-47b9-86d8-b28b56f5df60" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets_1ad1991e-588d-47b9-86d8-b28b56f5df60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_18ce54bb-5764-4018-a817-7ec8bb91aeec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_18ce54bb-5764-4018-a817-7ec8bb91aeec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_74acd982-93bc-48e0-a753-fb69b33ac735" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable_74acd982-93bc-48e0-a753-fb69b33ac735" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_57a92f2b-7fdf-48c1-9851-cd36eec02ac3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_57a92f2b-7fdf-48c1-9851-cd36eec02ac3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserve_c038ea62-1d4a-45df-8908-05b5914df295" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserve"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_RestructuringReserve_c038ea62-1d4a-45df-8908-05b5914df295" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_d0ca4aea-17db-485b-9514-a513bac0b33f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue_d0ca4aea-17db-485b-9514-a513bac0b33f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_6c070f3c-2f2c-4856-b9dd-edbd788e1984" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_6c070f3c-2f2c-4856-b9dd-edbd788e1984" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_c9e92b5d-36ba-4ad5-8717-d6d8bb252b90" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles_c9e92b5d-36ba-4ad5-8717-d6d8bb252b90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2ac370bb-dbc9-4731-b215-4549d1e2c206" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2ac370bb-dbc9-4731-b215-4549d1e2c206" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_efae33e3-4c4c-482c-b4c1-dc5ad8c5807b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_Goodwill_efae33e3-4c4c-482c-b4c1-dc5ad8c5807b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a31ee220-acbc-408f-baeb-02125b7fc6d0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_c0426709-7924-482c-9109-c93ea8515a69" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_a31ee220-acbc-408f-baeb-02125b7fc6d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BusinessCombinationsConsiderationTransferredDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsAbstract_341c3116-e4c1-4bf3-a9b5-67afe73079fe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessCombinationsAbstract_341c3116-e4c1-4bf3-a9b5-67afe73079fe" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_37bf7dbd-ef96-4e0e-b1ef-3c8e1eb129f7" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_e3993c33-a939-43bb-b9f2-e156c07d9a58" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:to="loc_lgnd_CrystalMember_e3993c33-a939-43bb-b9f2-e156c07d9a58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OMTInc.Member_6d9feaad-1522-4a8f-92c8-4956b157a6c5" xlink:href="lgnd-20181231.xsd#lgnd_OMTInc.Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_13ca9981-8132-47ab-884b-91f5dfc74f26" xlink:to="loc_lgnd_OMTInc.Member_6d9feaad-1522-4a8f-92c8-4956b157a6c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_de2a3d86-b5ed-4315-b8cd-2edf5973ea9a" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPaidtoAcquireBusiness_e8c75801-6a4d-4179-9bbe-9a85ba9186b7" xlink:href="lgnd-20181231.xsd#lgnd_CashPaidtoAcquireBusiness"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_CashPaidtoAcquireBusiness_e8c75801-6a4d-4179-9bbe-9a85ba9186b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CashPayable_52d845f7-1f3a-41b5-ae59-37c2bf3f9d98" xlink:href="lgnd-20181231.xsd#lgnd_CashPayable"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_CashPayable_52d845f7-1f3a-41b5-ae59-37c2bf3f9d98" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_9ef59607-5cac-43fe-b055-cbc0cfaca514" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_9ef59607-5cac-43fe-b055-cbc0cfaca514" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_2d689f2a-0312-40be-b0c8-8652b92154e0" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration_2d689f2a-0312-40be-b0c8-8652b92154e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_2832eef4-25a3-464f-b462-feb4b01bd413" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_2832eef4-25a3-464f-b462-feb4b01bd413" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_973d96f9-1784-4ef3-ae9c-c3c84e1d0f4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_973d96f9-1784-4ef3-ae9c-c3c84e1d0f4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharePrice_d163b413-37c6-4c90-a036-f487a80899f6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharePrice"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_SharePrice_d163b413-37c6-4c90-a036-f487a80899f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_9df999df-52cb-43ec-ab93-d947ffce0836" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned_9df999df-52cb-43ec-ab93-d947ffce0836" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_071b0965-8de7-47ac-b086-0f9e5928364c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_00ef8187-56a4-4140-b87c-3a563b0c2531" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_071b0965-8de7-47ac-b086-0f9e5928364c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurement" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurement"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/FairValueMeasurement" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_8d243a2b-77f1-4992-92cd-30c5566e7172" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_b3af077c-97b8-4dce-be8f-a435ac180377" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FinancialInstrumentsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_8d243a2b-77f1-4992-92cd-30c5566e7172" xlink:to="loc_us-gaap_FinancialInstrumentsDisclosureTextBlock_b3af077c-97b8-4dce-be8f-a435ac180377" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_29d6cba4-1f6c-43b9-8c11-cde29d011822" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_85b745ed-e364-48f9-ac5e-6e67f40dc08e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_29d6cba4-1f6c-43b9-8c11-cde29d011822" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_85b745ed-e364-48f9-ac5e-6e67f40dc08e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_c88368f7-ad03-4391-9446-0570263dc749" xlink:href="lgnd-20181231.xsd#lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_29d6cba4-1f6c-43b9-8c11-cde29d011822" xlink:to="loc_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock_c88368f7-ad03-4391-9446-0570263dc749" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_1c33a281-798a-436e-b2fc-aad2519215ac" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_1c33a281-798a-436e-b2fc-aad2519215ac" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_1e714f73-7ab4-4c17-933f-32272c7aea0d" xlink:to="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_de3aeaa9-d9a0-4771-9046-74254863dd95" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_056455ed-ce05-4fe0-a69c-96c1267bda83" xlink:to="loc_srt_MaximumMember_de3aeaa9-d9a0-4771-9046-74254863dd95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TimingOfTransferOfGoodOrServiceDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceAxis_f7337bc9-8caf-48d0-a00f-8e3e6bb6e0a1" xlink:to="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TransferredOverTimeMember_01613492-1b99-4098-830b-19623c03a4ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TransferredOverTimeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TimingOfTransferOfGoodOrServiceDomain_d232a90a-30b0-477e-911e-d7276bb1e3af" xlink:to="loc_us-gaap_TransferredOverTimeMember_01613492-1b99-4098-830b-19623c03a4ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_60d1509e-a636-466c-97d6-5ee210e8b8f0" xlink:to="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_25f8b3d3-94f9-466f-a0f2-eea9ea3b09d7" xlink:href="lgnd-20181231.xsd#lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember_25f8b3d3-94f9-466f-a0f2-eea9ea3b09d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_Phase3ClinicalTrialMember_773b45df-9f5f-44ac-b4c4-840558db2b70" xlink:href="lgnd-20181231.xsd#lgnd_Phase3ClinicalTrialMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_Phase3ClinicalTrialMember_773b45df-9f5f-44ac-b4c4-840558db2b70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MilestonePaymentsAndRoyaltiesMember_18c18f68-8c99-4bd0-88b0-2908a122531a" xlink:href="lgnd-20181231.xsd#lgnd_MilestonePaymentsAndRoyaltiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_7d6fcf2c-a3ba-4fea-91cf-f285657ca6c7" xlink:to="loc_lgnd_MilestonePaymentsAndRoyaltiesMember_18c18f68-8c99-4bd0-88b0-2908a122531a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_610072a4-c13b-4321-9645-6437acebeb9c" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_202024d5-9b88-485a-8584-774d8749b56b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_c2586d7a-2877-40f8-87f4-85b28d6ae336" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_202024d5-9b88-485a-8584-774d8749b56b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_165437fb-ae92-4144-af2b-fc1ae9e64dec" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_d3e9adf3-bf88-4114-9534-b01881fdad73" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_fd161b7f-c9d0-4293-bce1-8710e87d8570" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_d3e9adf3-bf88-4114-9534-b01881fdad73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_423dc49b-414a-4308-a224-19834943c92f" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_a1d9f8ad-6ab2-46db-8126-82bea9a99804" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_a1d9f8ad-6ab2-46db-8126-82bea9a99804" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_ef40369a-9191-4bd1-837a-dfaf6876dcb4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_ef40369a-9191-4bd1-837a-dfaf6876dcb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_af4ef7f9-6331-4da3-95fc-8a2b27354922" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_ca84938b-be51-4945-943a-edbc161491f7" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_af4ef7f9-6331-4da3-95fc-8a2b27354922" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByAssetClassAxis"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByAssetClassAxis_c6502433-34e7-4c7d-899b-e2dc6d9475d8" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_7cf256e0-4b59-483d-b97a-53f7abae2599" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_7cf256e0-4b59-483d-b97a-53f7abae2599" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesReceivableMember_abd834ad-0d7c-496d-a5e9-4c91e0b38d50" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesReceivableMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_NotesReceivableMember_abd834ad-0d7c-496d-a5e9-4c91e0b38d50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_c696a93b-b02c-4ada-b28a-8f0b56f4dc79" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain_2b791108-b99a-48ea-b099-d6eceec3ff40" xlink:to="loc_us-gaap_WarrantMember_c696a93b-b02c-4ada-b28a-8f0b56f4dc79" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_fbc4b964-2979-4011-974e-c937a9155098" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_16be8efd-08ba-44be-858a-07e40e4b4aa5" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCrystalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyCrystalMember_16be8efd-08ba-44be-858a-07e40e4b4aa5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_5f5ac6b4-0b8c-4d3b-9ac6-dbd605296497" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyCydexMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyCydexMember_5f5ac6b4-0b8c-4d3b-9ac6-dbd605296497" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_f3ea3234-521e-4931-b3da-7616d25609ec" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember_f3ea3234-521e-4931-b3da-7616d25609ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_31e10898-0c2e-4850-959a-fba876b2ca70" xlink:href="lgnd-20181231.xsd#lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_e31fe6b4-cf07-41e1-a61c-7caed70cfeb7" xlink:to="loc_lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember_31e10898-0c2e-4850-959a-fba876b2ca70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_3202a2dd-64d1-4842-8f06-51f8d0d29f6d" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_f0bf92ab-071c-4145-9271-9d082c5ed5bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_f0bf92ab-071c-4145-9271-9d082c5ed5bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_f6795747-23ce-45ab-b8d8-87ab4866c4ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_LiabilitiesFairValueDisclosure_f6795747-23ce-45ab-b8d8-87ab4866c4ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AlternativeInvestmentMeasurementInput_d3e1942e-4166-465f-b4ec-ebe5070af3af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AlternativeInvestmentMeasurementInput"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_AlternativeInvestmentMeasurementInput_d3e1942e-4166-465f-b4ec-ebe5070af3af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_60ec97b9-3806-4126-9d2e-6509ca0a058b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements_60ec97b9-3806-4126-9d2e-6509ca0a058b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_54e44dda-c192-426c-b4f1-959be386b0e3" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease_54e44dda-c192-426c-b4f1-959be386b0e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetGross_4c4f8582-ee23-4949-8d1e-d82cfe5d8706" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ContractWithCustomerAssetGross"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_7a4e9690-c37c-4afc-87b7-7ed52149babe" xlink:to="loc_us-gaap_ContractWithCustomerAssetGross_4c4f8582-ee23-4949-8d1e-d82cfe5d8706" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_f048b32f-ed80-43dd-89c8-c89603a2583c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_f048b32f-ed80-43dd-89c8-c89603a2583c" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_d1bf4f29-30e8-4196-9898-29e7964cd11d" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_2867ca9d-f8b3-4ac3-9132-f01b153c0660" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CrystalMember_2867ca9d-f8b3-4ac3-9132-f01b153c0660" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexMember_a76bcc50-2cc0-4fdc-928f-d0dede81e90e" xlink:href="lgnd-20181231.xsd#lgnd_CydexMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CydexMember_a76bcc50-2cc0-4fdc-928f-d0dede81e90e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexandCrystalMember_e18fbd73-765f-4fe4-9cca-8e6c109ed40f" xlink:href="lgnd-20181231.xsd#lgnd_CydexandCrystalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_956d81fe-0d35-4b52-99de-ec22e7633aad" xlink:to="loc_lgnd_CydexandCrystalMember_e18fbd73-765f-4fe4-9cca-8e6c109ed40f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_ef64758e-72c1-442c-8605-183748734412" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_6d5b0280-d22a-48f6-8da4-68a7f7980619" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_4274d3d7-3ef1-4231-8bac-a77509f81834" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_6d5b0280-d22a-48f6-8da4-68a7f7980619" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_EquityMethodInvesteeNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis_590d0da0-5180-4803-97f2-28798cee277f" xlink:to="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_VikingTherapeuticsInc.Member_0b1119f5-a404-4d21-841b-efba22c73aeb" xlink:href="lgnd-20181231.xsd#lgnd_VikingTherapeuticsInc.Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_EquityMethodInvesteeNameDomain_0dd40473-aac2-445d-913e-7be1e094230f" xlink:to="loc_lgnd_VikingTherapeuticsInc.Member_0b1119f5-a404-4d21-841b-efba22c73aeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_15f7c2ca-85da-43a6-8105-c78e4ce93959" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesMember_a4ebc76e-1557-424a-8a73-2ec5571077dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SeniorNotesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_ee4afc76-042b-4d6b-bb97-5f8622bbde42" xlink:to="loc_us-gaap_SeniorNotesMember_a4ebc76e-1557-424a-8a73-2ec5571077dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_4a08140b-efe5-4350-8fc4-608d0e5a117e" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_2f187e1a-785d-48c3-81d0-9dadbd074ed7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_2f187e1a-785d-48c3-81d0-9dadbd074ed7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_c1140c2e-d3bb-4aea-a18b-6dfe7cfdc213" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_c1140c2e-d3bb-4aea-a18b-6dfe7cfdc213" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_07b1ea39-2069-4f03-bc4c-64d14a37fb19" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3_07b1ea39-2069-4f03-bc4c-64d14a37fb19" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_13fde998-f8a8-4463-b3d9-39b57568f3cd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_9d9bf010-4097-4e03-b491-229cf48e195c" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue_13fde998-f8a8-4463-b3d9-39b57568f3cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_9f7f0c0c-d346-4b85-be8d-012ae991b88f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_ec204e5a-9ce4-45f6-86c6-424a1f74a917" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_ec204e5a-9ce4-45f6-86c6-424a1f74a917" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHolders_d32a8f20-9ec8-4a08-8dc5-380df5bc75e0" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHolders"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_lgnd_PaymentsToContingentValueRightHolders_d32a8f20-9ec8-4a08-8dc5-380df5bc75e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_da0690f0-fa85-4f8a-960d-bf6f957e89c3" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_da0690f0-fa85-4f8a-960d-bf6f957e89c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_eff4d3fc-d79c-4ae6-9ec3-7cfa4800921f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_bf5c5271-8e3e-4335-97ac-023249d3b0e5" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_eff4d3fc-d79c-4ae6-9ec3-7cfa4800921f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligations" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligations"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/LeaseObligations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_6b6d7dc0-3fe2-4124-aae2-28c9db13b9f9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesOfLesseeDisclosureTextBlock_53e42c57-ad63-4425-9ae8-3f7e253d410a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOfLesseeDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_6b6d7dc0-3fe2-4124-aae2-28c9db13b9f9" xlink:to="loc_us-gaap_LeasesOfLesseeDisclosureTextBlock_53e42c57-ad63-4425-9ae8-3f7e253d410a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/LeaseObligationsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_a53f45ec-f404-4c08-af3e-14dc74f9e9d3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock_1a76693a-a908-4d6e-ad69-8ee5fa667f83" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_a53f45ec-f404-4c08-af3e-14dc74f9e9d3" xlink:to="loc_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock_1a76693a-a908-4d6e-ad69-8ee5fa667f83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/LeaseObligationsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_debeed17-d669-46ff-a87c-3a67586ab516" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseAndRentalExpense_678cb022-a391-4285-9e31-49f953beec5d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseAndRentalExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_debeed17-d669-46ff-a87c-3a67586ab516" xlink:to="loc_us-gaap_LeaseAndRentalExpense_678cb022-a391-4285-9e31-49f953beec5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesAbstract_662ecfb7-122a-437f-8083-1b6d17c3649f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOperatingLeasedAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesAbstract_662ecfb7-122a-437f-8083-1b6d17c3649f" xlink:to="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis_afda4c3d-1a2f-4998-b2a5-63baaa81568b" xlink:to="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateHeadquartersSanDiegoCAMember_8b76647e-8c0f-4a65-999a-374150247a88" xlink:href="lgnd-20181231.xsd#lgnd_CorporateHeadquartersSanDiegoCAMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_CorporateHeadquartersSanDiegoCAMember_8b76647e-8c0f-4a65-999a-374150247a88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember_ff023567-9c4e-40fb-b531-af3a1692d562" xlink:href="lgnd-20181231.xsd#lgnd_OfficeandResearchFacilityLaJollaCAMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeandResearchFacilityLaJollaCAMember_ff023567-9c4e-40fb-b531-af3a1692d562" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_678e5555-ae23-4942-aef0-d2aba2384dda" xlink:href="lgnd-20181231.xsd#lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember_678e5555-ae23-4942-aef0-d2aba2384dda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeEmeryvilleCAMember_b3f70ece-2e29-4cf5-a6c5-3412a9c8e087" xlink:href="lgnd-20181231.xsd#lgnd_OfficeEmeryvilleCAMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeEmeryvilleCAMember_b3f70ece-2e29-4cf5-a6c5-3412a9c8e087" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityEmeryvilleCAMember_13a7122b-8ae3-471e-8994-d2c21a80227a" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityEmeryvilleCAMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_ResearchFacilityEmeryvilleCAMember_13a7122b-8ae3-471e-8994-d2c21a80227a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OfficeWinnershUnitedKingdomMember_253b0168-c0a6-4e4b-ae00-cf66c074df8e" xlink:href="lgnd-20181231.xsd#lgnd_OfficeWinnershUnitedKingdomMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_OfficeWinnershUnitedKingdomMember_253b0168-c0a6-4e4b-ae00-cf66c074df8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_1b583ac1-3db5-414c-a457-2b309aacc4f2" xlink:href="lgnd-20181231.xsd#lgnd_ResearchFacilityCambridgeUnitedKingdomMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain_4111c704-48ae-4a23-9440-de1e266130a5" xlink:to="loc_lgnd_ResearchFacilityCambridgeUnitedKingdomMember_1b583ac1-3db5-414c-a457-2b309aacc4f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_StatementGeographicalAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:to="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_SegmentGeographicalDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_StatementGeographicalAxis_9712c6c9-9ca3-4d7e-befb-cfa06cec5ff6" xlink:to="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_CA_92523ace-11e4-4c9b-95f5-7875c4770544" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_CA"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_stpr_CA_92523ace-11e4-4c9b-95f5-7875c4770544" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_stpr_KS_9e89f9cc-7231-4c85-b4ba-7f28bf6fa5c9" xlink:href="https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd#stpr_KS"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_stpr_KS_9e89f9cc-7231-4c85-b4ba-7f28bf6fa5c9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_country_GB_26f4dbd4-7471-4389-bfee-9f167fdaa9e7" xlink:href="http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd#country_GB"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_SegmentGeographicalDomain_d22e16a2-862d-432a-9d13-b53734eca761" xlink:to="loc_country_GB_26f4dbd4-7471-4389-bfee-9f167fdaa9e7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasedAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfOperatingLeasedAssetsTable_5820ac74-1121-41dd-9e87-928bbcbe0132" xlink:to="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeasesOperatingAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLeasedAssetsLineItems_b5ad3640-b6c3-4acf-ace4-1a4112052ba8" xlink:to="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_aa0ee12d-7d2e-4718-9006-7608d16a8006" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent_aa0ee12d-7d2e-4718-9006-7608d16a8006" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_88402da9-47e3-4841-a143-c925a48ae054" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears_88402da9-47e3-4841-a143-c925a48ae054" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_485df591-0144-4ee0-befa-fb6dc9c3ee4f" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears_485df591-0144-4ee0-befa-fb6dc9c3ee4f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_7605a001-8c88-41eb-97fa-abef864dd78a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDue_7605a001-8c88-41eb-97fa-abef864dd78a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_e3e9d7f6-8cc8-4e28-853a-b0f299e481fd" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths_e3e9d7f6-8cc8-4e28-853a-b0f299e481fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_fec03709-4f85-4bec-a2e5-11a43ad54c25" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears_fec03709-4f85-4bec-a2e5-11a43ad54c25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_fb167081-e82e-4d82-ab6d-f257258b679f" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears_fb167081-e82e-4d82-ab6d-f257258b679f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_ba883b28-d6dc-4361-9b29-b99fd3bd6a15" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals_ba883b28-d6dc-4361-9b29-b99fd3bd6a15" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_784680da-7217-4a5d-a861-8ad14f1d76cd" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet_784680da-7217-4a5d-a861-8ad14f1d76cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_4b02080b-825f-48b8-ba0e-95299c06d638" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet_4b02080b-825f-48b8-ba0e-95299c06d638" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_e1d8c186-bed3-47f0-8de1-fc3e5ef0d6ad" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet_e1d8c186-bed3-47f0-8de1-fc3e5ef0d6ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_cd81c1df-9fe5-4109-9d56-39fa538ef68a" xlink:href="lgnd-20181231.xsd#lgnd_OperatingLeasesFutureMinimumPaymentsDueNet"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LeasesOperatingAbstract_c3b1db50-8a5f-4ace-b6f5-011eee1c620f" xlink:to="loc_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet_cd81c1df-9fe5-4109-9d56-39fa538ef68a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotes"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_3c577e16-09e0-4413-8826-ec481ccaa3e7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_0ce55148-7241-4c34-af64-a7760c1b39bf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_3c577e16-09e0-4413-8826-ec481ccaa3e7" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_0ce55148-7241-4c34-af64-a7760c1b39bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_77fb93f0-cde9-438d-bd5d-e7603a96c1f2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtTableTextBlock_52909d7b-7151-4242-9c30-47f5f16c15be" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDebtTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_77fb93f0-cde9-438d-bd5d-e7603a96c1f2" xlink:to="loc_us-gaap_ScheduleOfDebtTableTextBlock_52909d7b-7151-4242-9c30-47f5f16c15be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_327204f9-69b3-482c-ac86-cdeeac8a5981" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_327204f9-69b3-482c-ac86-cdeeac8a5981" xlink:to="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_08a6468c-23b3-4734-85a3-805a66c82e60" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_914ae39c-48c2-4102-aa9d-12498f8e488a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_4dc0dd44-c7a7-49a3-a1fe-ba153cecf8b6" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_914ae39c-48c2-4102-aa9d-12498f8e488a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_4774523c-79c8-443d-8ff4-65129ac11e67" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_09e3d820-b99c-434e-a723-85a862422047" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_09e3d820-b99c-434e-a723-85a862422047" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_a335e6fd-6145-4dd9-9935-6900f35c522f" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_948b043e-0a2e-4f9b-a9c4-ec9f17628516" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_a335e6fd-6145-4dd9-9935-6900f35c522f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodAxis_b2cfbada-ca06-47fd-9123-7b5a8b48d53e" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_3366ca6a-8fe3-420a-9000-0c77160ae63e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodOneMember_3366ca6a-8fe3-420a-9000-0c77160ae63e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_dbc1cd6b-3775-4ef9-8866-d8113591be0f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentRedemptionPeriodTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentRedemptionPeriodDomain_644c8656-2465-4e53-85b2-67d55d0f5954" xlink:to="loc_us-gaap_DebtInstrumentRedemptionPeriodTwoMember_dbc1cd6b-3775-4ef9-8866-d8113591be0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_63113425-5625-41d8-9b22-e8d891524142" xlink:to="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_e6589bdf-546b-4a3b-8e28-241cbad75aba" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_e6589bdf-546b-4a3b-8e28-241cbad75aba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_89240001-84a6-48f0-ae8e-306427859e3d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDebtNetOfIssuanceCosts"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ProceedsFromDebtNetOfIssuanceCosts_89240001-84a6-48f0-ae8e-306427859e3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_5d35072c-57ce-4a0d-b256-425eff734a26" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_5d35072c-57ce-4a0d-b256-425eff734a26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_7b624207-9e2a-405f-9cbd-626b21f18382" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionRatio1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionRatio1_7b624207-9e2a-405f-9cbd-626b21f18382" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_8551cac7-ad33-4c39-a631-60e402661b4e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleConversionPrice1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleConversionPrice1_8551cac7-ad33-4c39-a631-60e402661b4e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c77a45d0-8d7d-426c-bd5a-d03abddfa8d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentInterestRateStatedPercentage"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentInterestRateStatedPercentage_c77a45d0-8d7d-426c-bd5a-d03abddfa8d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_4e334203-5919-4561-b15c-efc7329873ad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdTradingDays"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdTradingDays_4e334203-5919-4561-b15c-efc7329873ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_afbde1ab-e3fe-4ae0-a4db-2edacb56f47a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1_afbde1ab-e3fe-4ae0-a4db-2edacb56f47a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_26eafd80-a84e-497f-8962-3ca83b0861f9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger_26eafd80-a84e-497f-8962-3ca83b0861f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_c1aeb084-a4a3-460f-a4be-68b38a9580f6" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger_c1aeb084-a4a3-460f-a4be-68b38a9580f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_df1da3ce-b958-4269-aa15-af3ec32f81d6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_df1da3ce-b958-4269-aa15-af3ec32f81d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_4edda9eb-229e-416c-80a5-459efd113a0f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal_4edda9eb-229e-416c-80a5-459efd113a0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_9aac0aae-f682-450c-9704-897207cc6071" xlink:href="lgnd-20181231.xsd#lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal_9aac0aae-f682-450c-9704-897207cc6071" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_51552ded-b922-4ebc-a8bc-1d5b75d0a77c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtConversionConvertedInstrumentAmount1"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtConversionConvertedInstrumentAmount1_51552ded-b922-4ebc-a8bc-1d5b75d0a77c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_dfee3921-3eea-4d9a-9c8c-a4b326e331b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature_dfee3921-3eea-4d9a-9c8c-a4b326e331b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a7254fe-dae1-4f90-b73d-6a7531acd6ce" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0a7254fe-dae1-4f90-b73d-6a7531acd6ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_15b3275a-97b2-4abc-a546-f7c3207f347a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights_15b3275a-97b2-4abc-a546-f7c3207f347a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceofConvertibleBondHedge_2a1b7bc9-c0b4-4016-aff6-77de8c96b56f" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceofConvertibleBondHedge"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_ExercisePriceofConvertibleBondHedge_2a1b7bc9-c0b4-4016-aff6-77de8c96b56f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsforConvertibleBondHedges_127c3cbb-b8be-4c0e-890c-392523db8d8f" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsforConvertibleBondHedges"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_PaymentsforConvertibleBondHedges_127c3cbb-b8be-4c0e-890c-392523db8d8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeAssetsCurrent_27d4ae7b-9071-4d51-954e-4b9df4f50aee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeAssetsCurrent"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DerivativeAssetsCurrent_27d4ae7b-9071-4d51-954e-4b9df4f50aee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1d26d7ee-6d4d-4512-8c4e-a89552f91a4c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_1d26d7ee-6d4d-4512-8c4e-a89552f91a4c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_1e48be64-c1eb-4d9a-8341-43b82cb710a3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities_1e48be64-c1eb-4d9a-8341-43b82cb710a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7254ee3d-eea2-4bdc-8cde-ddc551535d95" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_7254ee3d-eea2-4bdc-8cde-ddc551535d95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_8214874f-b6d6-46e5-a18e-eb5d779a6123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued_8214874f-b6d6-46e5-a18e-eb5d779a6123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_0497e767-7f59-43d7-a44c-647df3c5d3a8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability_0497e767-7f59-43d7-a44c-647df3c5d3a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsGross_78e1d26e-40b8-42bb-b867-936bfb77a132" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFinanceCostsGross"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DeferredFinanceCostsGross_78e1d26e-40b8-42bb-b867-936bfb77a132" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_751210e0-acaf-4f75-a73e-0df728e618fd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt_751210e0-acaf-4f75-a73e-0df728e618fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedPremium_97fd92f4-d30b-4531-a9cf-ae6b4cebe501" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedPremium"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedPremium_97fd92f4-d30b-4531-a9cf-ae6b4cebe501" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtNoncurrent_00ce2155-d17e-4dcd-a781-7c9dbd5b9e2f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtNoncurrent"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ConvertibleDebtNoncurrent_00ce2155-d17e-4dcd-a781-7c9dbd5b9e2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsSettled_c780f3f8-ce34-4810-9ae2-e863844f168f" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsSettled"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_WarrantsSettled_c780f3f8-ce34-4810-9ae2-e863844f168f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_cce8499a-15e7-48a9-8224-f4b2c66f63a1" xlink:href="lgnd-20181231.xsd#lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled"/>
    <link:presentationArc order="31" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled_cce8499a-15e7-48a9-8224-f4b2c66f63a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1e045ef0-315b-4de9-819b-4e64180072a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PaymentsForRepurchaseOfWarrants"/>
    <link:presentationArc order="32" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfWarrants_1e045ef0-315b-4de9-819b-4e64180072a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DerivativeGainLossOnDerivativeNet_bdcf9fb3-7cc1-4ee5-87c2-2c1047278038" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DerivativeGainLossOnDerivativeNet"/>
    <link:presentationArc order="33" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_DerivativeGainLossOnDerivativeNet_bdcf9fb3-7cc1-4ee5-87c2-2c1047278038" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_d447b22d-3768-40b4-af62-0ea0e49939ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:presentationArc order="34" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_d447b22d-3768-40b4-af62-0ea0e49939ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeAssets_e3002d1f-7b96-4aeb-a75f-742ea294ee64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeAssets"/>
    <link:presentationArc order="35" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_IncreaseDecreaseInDerivativeAssets_e3002d1f-7b96-4aeb-a75f-742ea294ee64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities_b6b84b0c-2e42-419a-b974-51658de6a281" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncreaseDecreaseInDerivativeLiabilities"/>
    <link:presentationArc order="36" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_21b15bed-5841-42a6-81e1-e9dd6038fbad" xlink:to="loc_us-gaap_IncreaseDecreaseInDerivativeLiabilities_b6b84b0c-2e42-419a-b974-51658de6a281" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_0e0ed569-28f0-45ac-b36f-c24d859e3de6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_0e0ed569-28f0-45ac-b36f-c24d859e3de6" xlink:to="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:to="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermDebtTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeAxis_c9569367-33e4-41ba-b730-e233f838e324" xlink:to="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleNotesPayableMember_ec177813-18b5-4bac-8fae-02483b36730d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleNotesPayableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermDebtTypeDomain_f7cbf865-3857-48a3-89e6-35c7da54497f" xlink:to="loc_us-gaap_ConvertibleNotesPayableMember_ec177813-18b5-4bac-8fae-02483b36730d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:to="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_d1c4ead7-bf9d-45d1-990e-6a16cc0c7b58" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2019Member_290748d6-7852-4d2f-9d38-26429580db90" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2019Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:to="loc_lgnd_ConvertibleSeniorNotes2019Member_290748d6-7852-4d2f-9d38-26429580db90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ConvertibleSeniorNotes2023Member_a2eb02e7-1096-4838-bbb1-27c2c3e15d95" xlink:href="lgnd-20181231.xsd#lgnd_ConvertibleSeniorNotes2023Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ab04806-3048-4e80-98ae-3c2c3dd1b1cb" xlink:to="loc_lgnd_ConvertibleSeniorNotes2023Member_a2eb02e7-1096-4838-bbb1-27c2c3e15d95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_d0590e68-4ff9-4433-b4a1-71d326dd5e56" xlink:to="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_7bdf130e-16e4-496a-bcd9-ab77e7bd65ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_7bdf130e-16e4-496a-bcd9-ab77e7bd65ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscount_4cfa4dfe-013e-4029-92f2-9b4f1dab7bd9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentUnamortizedDiscount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscount_4cfa4dfe-013e-4029-92f2-9b4f1dab7bd9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NotesPayableCurrent_88f52c73-6a58-41f9-8855-b27c8ad1e1a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NotesPayableCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_NotesPayableCurrent_88f52c73-6a58-41f9-8855-b27c8ad1e1a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermNotesPayable_e441357c-9cea-4a0a-94e5-20a0cac3192e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LongTermNotesPayable"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract_20b50a74-3c52-4fe4-a41f-f9c62efc28ae" xlink:to="loc_us-gaap_LongTermNotesPayable_e441357c-9cea-4a0a-94e5-20a0cac3192e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_9d4157ca-0b0d-4bea-b45e-9dbc59459801" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent_9d4157ca-0b0d-4bea-b45e-9dbc59459801" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConvertibleDebtFairValueDisclosures_26f10dd5-15de-4c0f-b2e6-a97b7c0c018f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ConvertibleDebtFairValueDisclosures"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_3812cc48-0c32-441b-be11-7986be8a5257" xlink:to="loc_us-gaap_ConvertibleDebtFairValueDisclosures_26f10dd5-15de-4c0f-b2e6-a97b7c0c018f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_4ccc5443-4d51-4487-a5bc-0a2dbf96d65a" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_0ab1be35-2566-4dd7-a04a-83ef4cb52551" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SupplementalBalanceSheetDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_4ccc5443-4d51-4487-a5bc-0a2dbf96d65a" xlink:to="loc_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock_0ab1be35-2566-4dd7-a04a-83ef4cb52551" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_06e37f52-f546-4d50-9c1a-d104888ed1bc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock_06e37f52-f546-4d50-9c1a-d104888ed1bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock_d721973d-5963-436a-a122-0625281f3768" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock_d721973d-5963-436a-a122-0625281f3768" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_cf095090-a281-4c56-802e-92c27343c628" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_cf095090-a281-4c56-802e-92c27343c628" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_cc4f28ae-e015-4fd1-a7c0-ad261b8f6307" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock_cc4f28ae-e015-4fd1-a7c0-ad261b8f6307" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_8eca1198-e436-4491-9628-29bec6205167" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_8eca1198-e436-4491-9628-29bec6205167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleofContingentLiabilitiesTableTextBlock_f2b8a7da-b71b-441a-b4da-0820e97584bd" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleofContingentLiabilitiesTableTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ad48b106-6fff-4a40-820f-8ff89c71389a" xlink:to="loc_lgnd_ScheduleofContingentLiabilitiesTableTextBlock_f2b8a7da-b71b-441a-b4da-0820e97584bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsInvestmentCategoriesDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_e231476d-1ab7-486b-9d0a-d4ccec9d3203" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DebtSecuritiesAvailableForSaleTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_e231476d-1ab7-486b-9d0a-d4ccec9d3203" xlink:to="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:to="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InvestmentTypeCategorizationMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeAxis_330e00f1-7e93-4eef-9f7b-917e416c4e6b" xlink:to="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_InvestmentTypeCategorizationMember_c4022e07-d1aa-404e-b1f8-1ee2c99ff8c2" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DemandDepositsMember_9c28bc3b-27ac-4d66-9c25-662bb0bafe68" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DemandDepositsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_DemandDepositsMember_9c28bc3b-27ac-4d66-9c25-662bb0bafe68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CorporateDebtSecuritiesMember_c33bc703-14b4-4890-ac56-91f95dbc2283" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CorporateDebtSecuritiesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_CorporateDebtSecuritiesMember_c33bc703-14b4-4890-ac56-91f95dbc2283" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquitySecuritiesMember_031abb46-a063-4ee8-bab1-40b403843c9d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquitySecuritiesMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_EquitySecuritiesMember_031abb46-a063-4ee8-bab1-40b403843c9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommercialPaperMember_1198f7a1-2394-43f1-832a-d6bf849ce48a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommercialPaperMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_CommercialPaperMember_1198f7a1-2394-43f1-832a-d6bf849ce48a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b0ffa393-20a8-4d3c-bb40-e42c95efefcb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USGovernmentAgenciesDebtSecuritiesMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_USGovernmentAgenciesDebtSecuritiesMember_b0ffa393-20a8-4d3c-bb40-e42c95efefcb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_USTreasurySecuritiesMember_a9fb6df8-7048-4525-b632-668e8b5d007e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_USTreasurySecuritiesMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_USTreasurySecuritiesMember_a9fb6df8-7048-4525-b632-668e8b5d007e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MunicipalBondsMember_c3d1f820-1722-48a1-8861-2fb9855474db" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_MunicipalBondsMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShortTermInvestmentsMember_07c2b60b-d6e4-4fd2-8675-593ae16bb1c5" xlink:to="loc_us-gaap_MunicipalBondsMember_c3d1f820-1722-48a1-8861-2fb9855474db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleTable_788ef8cc-f15c-4960-8d6c-37166069ea28" xlink:to="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d0094685-d442-465a-8997-5350c3fa7df2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_d0094685-d442-465a-8997-5350c3fa7df2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee3f2178-4be7-48d5-9b52-2c3939e5a7ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_ee3f2178-4be7-48d5-9b52-2c3939e5a7ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_34e862a7-a941-4439-821d-ccdbf81c7191" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_34e862a7-a941-4439-821d-ccdbf81c7191" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9339e7df-4da4-4078-951e-3432f25fb5a2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems_479447cf-c83a-4541-864f-d901d5bac320" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_9339e7df-4da4-4078-951e-3432f25fb5a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsOtherCurrentAssetsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_3615c850-bd8e-44e1-af9e-5dd1a2054e39" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashCurrent_9dc9aa54-3337-4e14-b6b6-f3d8d5d8c4ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedCashCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_3615c850-bd8e-44e1-af9e-5dd1a2054e39" xlink:to="loc_us-gaap_RestrictedCashCurrent_9dc9aa54-3337-4e14-b6b6-f3d8d5d8c4ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_WarrantsCurrent_d316254d-cef9-41bd-b6f8-ce9dd0807a02" xlink:href="lgnd-20181231.xsd#lgnd_WarrantsCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_3615c850-bd8e-44e1-af9e-5dd1a2054e39" xlink:to="loc_lgnd_WarrantsCurrent_d316254d-cef9-41bd-b6f8-ce9dd0807a02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherAssetsCurrentOther_c951a2cc-0387-42f0-a0a2-1ee38702a68e" xlink:href="lgnd-20181231.xsd#lgnd_OtherAssetsCurrentOther"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_3615c850-bd8e-44e1-af9e-5dd1a2054e39" xlink:to="loc_lgnd_OtherAssetsCurrentOther_c951a2cc-0387-42f0-a0a2-1ee38702a68e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_da097830-0b48-4977-b787-5631c837d501" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_3615c850-bd8e-44e1-af9e-5dd1a2054e39" xlink:to="loc_us-gaap_OtherAssetsCurrent_da097830-0b48-4977-b787-5631c837d501" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsPropertyandEquipmentDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_6c1a7882-356a-4f4c-b80a-a6733605bca3" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_6c1a7882-356a-4f4c-b80a-a6733605bca3" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:to="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_5e252fdd-895a-416f-915f-fe84c35ffccd" xlink:to="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_67419d5b-cee8-4899-be85-b74ceafe61a6" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:to="loc_srt_MinimumMember_67419d5b-cee8-4899-be85-b74ceafe61a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_6f40db86-ff53-4f6e-a63a-f59484093830" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_0a17d5ac-9601-4d30-874b-08530b6c2721" xlink:to="loc_srt_MaximumMember_6f40db86-ff53-4f6e-a63a-f59484093830" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_99660123-d176-4931-b07a-d9e17bb51de7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OfficeEquipmentMember_40ff1e44-4c0a-43a9-b7d1-48732831aaf9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OfficeEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_us-gaap_OfficeEquipmentMember_40ff1e44-4c0a-43a9-b7d1-48732831aaf9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_d50fe32a-1edf-426e-97bd-4467f293d6b1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_d50fe32a-1edf-426e-97bd-4467f293d6b1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ComputerEquipmentAndSoftwareMember_6e7c310c-30cb-4348-9272-e8326c8cc0f9" xlink:href="lgnd-20181231.xsd#lgnd_ComputerEquipmentAndSoftwareMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5f5b49e7-aab8-4c7a-bd90-bfb7cbe0de17" xlink:to="loc_lgnd_ComputerEquipmentAndSoftwareMember_6e7c310c-30cb-4348-9272-e8326c8cc0f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_8e8bc2c0-a300-429c-b0e6-71004e7302b7" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_61a46231-b337-417f-b450-6ed96a67c7dd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_61a46231-b337-417f-b450-6ed96a67c7dd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4e52f053-5b59-4625-9589-1968e6032538" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_4e52f053-5b59-4625-9589-1968e6032538" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_a1ac148d-c179-458f-bc11-e04a0ed7ced3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_a1ac148d-c179-458f-bc11-e04a0ed7ced3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_e4e1e0c9-1eef-4c75-93a4-d81dc0b2b62a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PropertyPlantAndEquipmentUsefulLife"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentUsefulLife_e4e1e0c9-1eef-4c75-93a4-d81dc0b2b62a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_996416df-38c1-44d2-b16e-7e918d2861f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_c1c50e15-48a2-4a9d-8d0f-e8c23050a43c" xlink:to="loc_us-gaap_Depreciation_996416df-38c1-44d2-b16e-7e918d2861f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_ce6f1cce-cb25-4629-a97e-1de871ae875e" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_ce6f1cce-cb25-4629-a97e-1de871ae875e" xlink:to="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis_9001d7f4-85ae-49f4-8dfc-9ba63c7ca7c0" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember_0cda7486-84c1-403e-b897-8f76c99fa49a" xlink:href="lgnd-20181231.xsd#lgnd_AcquiredInProcessResearchAndDevelopmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain_f23e9650-42e0-4016-b73c-1ce6dadcbac1" xlink:to="loc_lgnd_AcquiredInProcessResearchAndDevelopmentMember_0cda7486-84c1-403e-b897-8f76c99fa49a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis_70a3149a-27c8-4bd0-86e6-b2b6865b3ca7" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PatentedTechnologyMember_8923c2a0-654b-439a-82f6-84650cf5c128" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PatentedTechnologyMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_PatentedTechnologyMember_8923c2a0-654b-439a-82f6-84650cf5c128" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TradeNamesMember_44d58154-73d0-4e8d-88ac-a803075d8d13" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TradeNamesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_TradeNamesMember_44d58154-73d0-4e8d-88ac-a803075d8d13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CustomerRelationshipsMember_4e0fcbcb-c09c-459f-a9c2-435386b8f878" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CustomerRelationshipsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain_8a1a0c12-be08-4ab2-8cbb-44e0df1b3168" xlink:to="loc_us-gaap_CustomerRelationshipsMember_4e0fcbcb-c09c-459f-a9c2-435386b8f878" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable_408da105-d34e-435c-8f78-4499f620ce9d" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_628f01a5-7eba-4c47-9c32-73577ecfdeb9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill_628f01a5-7eba-4c47-9c32-73577ecfdeb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_5be6d4c6-5d95-4345-a167-c987b59ea181" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_Goodwill"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_Goodwill_5be6d4c6-5d95-4345-a167-c987b59ea181" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6b96d811-403d-4bbf-ba48-637882d01419" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsGross"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsGross_6b96d811-403d-4bbf-ba48-637882d01419" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_acc2ea11-425e-40b1-8cbc-cf48aea50ada" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization_acc2ea11-425e-40b1-8cbc-cf48aea50ada" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_f3547410-6bf8-4772-bcea-284ec236f8f2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IntangibleAssetsNetIncludingGoodwill"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_IntangibleAssetsNetIncludingGoodwill_f3547410-6bf8-4772-bcea-284ec236f8f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d9c1d1da-ede5-4e54-add5-ffee97c456af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetUsefulLife"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetUsefulLife_d9c1d1da-ede5-4e54-add5-ffee97c456af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfIntangibleAssets_44a7eac8-7758-483a-9724-1493176368ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AmortizationOfIntangibleAssets"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_AmortizationOfIntangibleAssets_44a7eac8-7758-483a-9724-1493176368ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a1af3442-3b99-4894-acc4-da7e85cfa29c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths_a1af3442-3b99-4894-acc4-da7e85cfa29c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_ca159088-3f22-4eb8-8d61-ee51648e25a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo_ca159088-3f22-4eb8-8d61-ee51648e25a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_2d977ba5-432c-4b2a-9592-18d37f516f69" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree_2d977ba5-432c-4b2a-9592-18d37f516f69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3ce22fd-b5ca-444a-a1a9-b66c63247ebe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour_a3ce22fd-b5ca-444a-a1a9-b66c63247ebe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_c64ca83e-abd6-44c4-8886-61f2a2cd8cb8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive_c64ca83e-abd6-44c4-8886-61f2a2cd8cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c80ef063-c0fb-4c06-b988-077e36f19c86" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ImpairmentOfIntangibleAssetsFinitelived"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FiniteLivedIntangibleAssetsLineItems_f49d0205-986a-485e-b5f8-1911fa73a8bb" xlink:to="loc_us-gaap_ImpairmentOfIntangibleAssetsFinitelived_c80ef063-c0fb-4c06-b988-077e36f19c86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsAccruedLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_05c82898-5c8b-4d12-b3cc-f02c09e691c1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_05c82898-5c8b-4d12-b3cc-f02c09e691c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_98874be2-f411-479c-8183-476f44bc2108" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_98874be2-f411-479c-8183-476f44bc2108" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_dbeea9f1-0e6c-4abd-9636-4612c347e6a0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedSalesCommissionCurrentAndNoncurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent_dbeea9f1-0e6c-4abd-9636-4612c347e6a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_9509817f-d86a-4374-8d8b-4959e0d67def" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedRoyaltiesCurrentAndNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent_9509817f-d86a-4374-8d8b-4959e0d67def" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedStockRepurchases_0b96105f-699b-4173-b8ff-71292d70b533" xlink:href="lgnd-20181231.xsd#lgnd_AccruedStockRepurchases"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_lgnd_AccruedStockRepurchases_0b96105f-699b-4173-b8ff-71292d70b533" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AccruedSalesReturns_ba19aa9a-6c7c-4b11-9fc2-9dc956310327" xlink:href="lgnd-20181231.xsd#lgnd_AccruedSalesReturns"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_lgnd_AccruedSalesReturns_ba19aa9a-6c7c-4b11-9fc2-9dc956310327" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringReserveCurrent_38252141-6a04-4084-961b-f16ea970a394" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestructuringReserveCurrent"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_RestructuringReserveCurrent_38252141-6a04-4084-961b-f16ea970a394" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_812fdcc3-ab37-485c-b451-eabac178d3c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_812fdcc3-ab37-485c-b451-eabac178d3c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_8dd47bd3-2b76-4c8b-84bd-d84194191c87" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_60125c9b-7375-4de4-afdc-233efbcf3aa7" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_8dd47bd3-2b76-4c8b-84bd-d84194191c87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#BalanceSheetAccountDetailsContingentLiabilitiesDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_OtherBalanceSheetDetailsAbstract_8c457016-b546-4dd3-b6ba-888020491749" xlink:href="lgnd-20181231.xsd#lgnd_OtherBalanceSheetDetailsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_OtherBalanceSheetDetailsAbstract_8c457016-b546-4dd3-b6ba-888020491749" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_2617ea7b-8c33-4abc-b3cd-85a71a47f2c8" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CydexPharmaceuticalsIncMember_d8dd2160-2822-4778-bca4-05c30dea2cbe" xlink:href="lgnd-20181231.xsd#lgnd_CydexPharmaceuticalsIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_CydexPharmaceuticalsIncMember_d8dd2160-2822-4778-bca4-05c30dea2cbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_MetabasisTherapeuticsMember_856eafe2-b40d-4738-b0c9-70dfd26ff292" xlink:href="lgnd-20181231.xsd#lgnd_MetabasisTherapeuticsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_MetabasisTherapeuticsMember_856eafe2-b40d-4738-b0c9-70dfd26ff292" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CrystalMember_d49007f1-6047-40ac-8934-3e42a8a6fc9f" xlink:href="lgnd-20181231.xsd#lgnd_CrystalMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_0b35187f-295d-4a20-9512-bb017f5d5718" xlink:to="loc_lgnd_CrystalMember_d49007f1-6047-40ac-8934-3e42a8a6fc9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_d372c7c9-6d79-472c-96c6-f43c9b787d29" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_87d197b5-a170-448a-9f0a-b7a672c5e36f" xlink:href="lgnd-20181231.xsd#lgnd_RevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent_87d197b5-a170-448a-9f0a-b7a672c5e36f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_9606b558-3884-4502-818f-e87edfcf4490" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments_9606b558-3884-4502-818f-e87edfcf4490" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_d045e97f-6ed2-43ad-ab84-65eab0e0b581" xlink:href="lgnd-20181231.xsd#lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent_d045e97f-6ed2-43ad-ab84-65eab0e0b581" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_c30cf4c6-0258-4e69-b7cd-0612140705f4" xlink:href="lgnd-20181231.xsd#lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments_c30cf4c6-0258-4e69-b7cd-0612140705f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:href="lgnd-20181231.xsd#lgnd_ContingentLiabilityRollForward"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_22a43f9d-3607-4754-ba30-3f3e4c6a51dc" xlink:to="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_42071e80-e8fa-4fc7-ba07-5aa75d94d949" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_42071e80-e8fa-4fc7-ba07-5aa75d94d949" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_PaymentsToContingentValueRightHolders_e2ade7f6-cb40-4d30-9948-c725228f1a3a" xlink:href="lgnd-20181231.xsd#lgnd_PaymentsToContingentValueRightHolders"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_PaymentsToContingentValueRightHolders_e2ade7f6-cb40-4d30-9948-c725228f1a3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_ee48a2be-c887-48d3-a7b9-152a8451f5ce" xlink:href="lgnd-20181231.xsd#lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities_ee48a2be-c887-48d3-a7b9-152a8451f5ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_efcddd01-70f6-470c-bfed-3319a8e1f7e8" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions_efcddd01-70f6-470c-bfed-3319a8e1f7e8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_16532a00-17be-4ffd-baf7-16fb3ad4eba8" xlink:href="lgnd-20181231.xsd#lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ContingentLiabilityRollForward_cd6746f3-dac4-4e91-af64-6f6164e46f20" xlink:to="loc_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod_16532a00-17be-4ffd-baf7-16fb3ad4eba8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquity" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquity"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquity" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_ef04f213-a7be-4820-937e-09beb0de1e99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6d8aca34-4203-431c-8b2d-14b6b7ce9f1e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_ef04f213-a7be-4820-937e-09beb0de1e99" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_6d8aca34-4203-431c-8b2d-14b6b7ce9f1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock_2f3c377b-f745-4550-9d80-1daf102e6ec9" xlink:href="lgnd-20181231.xsd#lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:to="loc_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock_2f3c377b-f745-4550-9d80-1daf102e6ec9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_b10bf3f2-7ac6-40c1-8757-d8c414ca2e47" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_b10bf3f2-7ac6-40c1-8757-d8c414ca2e47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_ae0a971f-4b0e-4fb8-b21a-21395d22d945" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock_ae0a971f-4b0e-4fb8-b21a-21395d22d945" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_0fd25828-cbc3-441d-9d08-607e9b8eca18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_0fd25828-cbc3-441d-9d08-607e9b8eca18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_bb2c3d05-2be7-4a00-9e0d-baf5833e7891" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_326ff4a9-f3c7-4fc1-a351-f8a6a390d636" xlink:to="loc_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock_bb2c3d05-2be7-4a00-9e0d-baf5833e7891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_16738aa2-b12b-41ba-8b74-7cc296a9076e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_16738aa2-b12b-41ba-8b74-7cc296a9076e" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeAxis_5fba2b04-163e-42ff-8b14-60272feaa2c7" xlink:to="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsequentEventMember_cc049171-8809-4bc1-a148-4182cf23b650" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SubsequentEventMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsequentEventTypeDomain_7bdd29e4-4452-4cc6-b0c7-92556a3f756a" xlink:to="loc_us-gaap_SubsequentEventMember_cc049171-8809-4bc1-a148-4182cf23b650" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_be60f7e0-8b8c-4eaa-b080-95345767b0af" xlink:to="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_08c550c3-4357-4354-ac8e-cc05ab8d2240" xlink:href="lgnd-20181231.xsd#lgnd_TwoThousandTwoStockIncentivePlanMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:to="loc_lgnd_TwoThousandTwoStockIncentivePlanMember_08c550c3-4357-4354-ac8e-cc05ab8d2240" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_AmendedESPPMember_6cad393f-c687-4145-a878-3bca192e0831" xlink:href="lgnd-20181231.xsd#lgnd_AmendedESPPMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_97c308f0-59b7-44b1-a1b3-a6f3f8d02824" xlink:to="loc_lgnd_AmendedESPPMember_6cad393f-c687-4145-a878-3bca192e0831" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_17c23e32-2817-48e8-b5ec-e23c0a865a4b" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_d2f12fcb-75b2-48a8-9281-cee08b1e6468" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:to="loc_us-gaap_EmployeeStockOptionMember_d2f12fcb-75b2-48a8-9281-cee08b1e6468" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_0084247f-e782-43f0-ae5f-44970efc80bb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_79561075-b0c6-454a-b16a-1455b12b8c20" xlink:to="loc_us-gaap_RestrictedStockMember_0084247f-e782-43f0-ae5f-44970efc80bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_973717f6-378f-476f-b582-8366c5408e48" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_c2069988-fe7e-46d6-ba3c-c0f8e09399ea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized_c2069988-fe7e-46d6-ba3c-c0f8e09399ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_67bc1e0f-f841-4e1d-ba2e-8221acdb883c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_67bc1e0f-f841-4e1d-ba2e-8221acdb883c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_62f113ab-d491-435d-8749-4456a87cd606" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_62f113ab-d491-435d-8749-4456a87cd606" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_4ff11fe4-480a-4641-9736-633f81b90123" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue_4ff11fe4-480a-4641-9736-633f81b90123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_839fa8cc-f4bc-4c1e-a988-2d235afd04ee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_839fa8cc-f4bc-4c1e-a988-2d235afd04ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_f1cd06b7-a8f7-474a-b113-6306004bf0b4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_f1cd06b7-a8f7-474a-b113-6306004bf0b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bdadce86-ddca-4481-b5c0-0e37c9e8bb3c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_bdadce86-ddca-4481-b5c0-0e37c9e8bb3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_eb96feed-33e7-4433-9f8d-1bfeef1bbe64" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions_eb96feed-33e7-4433-9f8d-1bfeef1bbe64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:href="lgnd-20181231.xsd#lgnd_EmployeeStockPurchasePlanAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_7e4dafd7-c153-4a50-8cf6-830c15fc3096" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee_7e4dafd7-c153-4a50-8cf6-830c15fc3096" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_747ae42a-4b1c-4acf-99dc-a81caae3a7c3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_EmployeeStockPurchasePlanAbstract_bde9513a-0878-4de9-b180-b63ffd1b3c34" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod_747ae42a-4b1c-4acf-99dc-a81caae3a7c3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:href="lgnd-20181231.xsd#lgnd_CorporateShareRepurchaseAbstract"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_d89f03db-78b7-4660-be5a-4ddb3e311b32" xlink:to="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_0d13c2dc-f393-43f7-81df-7be74e02133f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_0d13c2dc-f393-43f7-81df-7be74e02133f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_3371547c-b880-4143-80b8-1647453a1272" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare_3371547c-b880-4143-80b8-1647453a1272" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodValue_2e6ee8fd-5ab2-4c10-a17c-26677ddd740d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchasedDuringPeriodValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodValue_2e6ee8fd-5ab2-4c10-a17c-26677ddd740d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_95c91410-328a-47ca-a3f7-c68299cdd237" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramAuthorizedAmount1"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramAuthorizedAmount1_95c91410-328a-47ca-a3f7-c68299cdd237" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramPeriodInForce1_889d9d0c-1008-4661-9452-0a5e53a34ad2" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramPeriodInForce1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramPeriodInForce1_889d9d0c-1008-4661-9452-0a5e53a34ad2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_cd0a97d6-2316-47d2-aa55-19e45a8fe806" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_CorporateShareRepurchaseAbstract_45711b18-d0f3-4458-ba2d-3227a82dec9b" xlink:to="loc_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1_cd0a97d6-2316-47d2-aa55-19e45a8fe806" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityShareBasedCompensationDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_a45ba658-e3b5-4c5a-a4cd-557ed7af37d8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_a45ba658-e3b5-4c5a-a4cd-557ed7af37d8" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_7734950a-b819-4819-900c-2574fb57db7a" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d22d8bd7-7e09-4b21-a21b-ea1f20db65b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_d22d8bd7-7e09-4b21-a21b-ea1f20db65b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bc7a0aff-14de-4340-a35e-a306405c89ff" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_bcc3d2d1-1a31-46b7-a986-7511fe18b11d" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_bc7a0aff-14de-4340-a35e-a306405c89ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_e27179b5-d598-4ec8-a106-ab4e89c8bd2a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_9a2d80d8-feb9-4fd5-b860-493ff0437e99" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_257332b1-1f89-4deb-9fa0-bcd46c78f253" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax_9a2d80d8-feb9-4fd5-b860-493ff0437e99" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityStockOptionPlanActivityDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_305e6e79-56be-4470-b2ad-10c7b584f108" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_305e6e79-56be-4470-b2ad-10c7b584f108" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_6c781830-4c0b-4e73-966d-1005f685915b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_6c781830-4c0b-4e73-966d-1005f685915b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_c53d8255-2114-4b8b-9acd-87ccc2e15462" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_c53d8255-2114-4b8b-9acd-87ccc2e15462" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_4034e4c8-f6c7-4be3-8697-55c3bc53d960" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_4034e4c8-f6c7-4be3-8697-55c3bc53d960" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_62fcfb5d-c8ea-4ce4-926c-9c4759192183" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_93cfc14c-2672-438e-ba61-7d5feee61389" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_62fcfb5d-c8ea-4ce4-926c-9c4759192183" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_02a195b5-64f7-4703-b499-d6869fa102f9" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_02a195b5-64f7-4703-b499-d6869fa102f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_750b1987-4bc8-40a9-b8ec-da7f32aacfad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_750b1987-4bc8-40a9-b8ec-da7f32aacfad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_bebba067-b3e2-4488-8667-35b904ad78c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_bebba067-b3e2-4488-8667-35b904ad78c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_aa6e5e81-abbf-4c25-bbea-729d9f37cf89" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_aa6e5e81-abbf-4c25-bbea-729d9f37cf89" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_d75c4c60-2b0f-419d-9f42-8fffc8a574cf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_d75c4c60-2b0f-419d-9f42-8fffc8a574cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_dc67156d-a35b-470a-abea-10fef5219fa4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_dc67156d-a35b-470a-abea-10fef5219fa4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_4f3ed300-06e6-4ad2-ab5d-71cf560f2632" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_7dad7734-512c-48c5-9268-fb982bf950fc" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_4f3ed300-06e6-4ad2-ab5d-71cf560f2632" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_8e8d0e5c-15aa-474e-9250-e0737453a75a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_8e8d0e5c-15aa-474e-9250-e0737453a75a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_7763c38e-246e-4804-824c-fd72af98b909" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_7763c38e-246e-4804-824c-fd72af98b909" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_1fb2de1d-ccb7-40a0-8d41-85a3d07641d5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_1fb2de1d-ccb7-40a0-8d41-85a3d07641d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_44a56be0-4c7b-4114-a415-a653f9b5aed4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_44a56be0-4c7b-4114-a415-a653f9b5aed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_fbdea399-c79e-4026-93a5-e92abcf96861" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_fbdea399-c79e-4026-93a5-e92abcf96861" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_a7ab9253-4dfd-4dde-af3f-8da2a273bffb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_a7ab9253-4dfd-4dde-af3f-8da2a273bffb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_d8e2a481-b35c-4004-9bef-97aafd966162" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_d8e2a481-b35c-4004-9bef-97aafd966162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_e6b6cfe8-4446-4eb2-9bc5-def81583a7d1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_473a1fda-e411-4038-bd1d-cfe86288b46d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_e6b6cfe8-4446-4eb2-9bc5-def81583a7d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityBreakdownofOptionsOutstandingDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_e6704772-87c7-42c3-a541-9a9b4eb75c00" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_e6704772-87c7-42c3-a541-9a9b4eb75c00" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis_f31a424c-1c6c-476f-8c25-8a4d1d0d7fea" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeElevenMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain_0b5d2efa-473e-4729-a6e6-8f290f19e7a5" xlink:to="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeOneMember_eb45da41-33f3-48a4-adee-e8b8bb812c9f" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeOneMember_eb45da41-33f3-48a4-adee-e8b8bb812c9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTwoMember_2debba52-c33a-46c1-a497-478186ea25a2" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeTwoMember_2debba52-c33a-46c1-a497-478186ea25a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeThreeMember_7ddf03ba-5e11-4212-86e9-c2a64766065d" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeThreeMember_7ddf03ba-5e11-4212-86e9-c2a64766065d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFourMember_4fb199f1-991f-40f4-9c72-513d6b1c6543" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFourMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeFourMember_4fb199f1-991f-40f4-9c72-513d6b1c6543" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeFiveMember_0c0676b4-3597-4b8a-af58-46a09be16bd4" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeFiveMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeFiveMember_0c0676b4-3597-4b8a-af58-46a09be16bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSixMember_99bd035f-d493-4faf-9755-f2e2da7707d7" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSixMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeSixMember_99bd035f-d493-4faf-9755-f2e2da7707d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeSevenMember_499c3f07-c174-4869-a36f-b71d753758b3" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeSevenMember"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeSevenMember_499c3f07-c174-4869-a36f-b71d753758b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeNineMember_f7c1c8c8-6462-4e82-8e1a-5de21ae38834" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeNineMember"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeNineMember_f7c1c8c8-6462-4e82-8e1a-5de21ae38834" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeTenMember_61af9fab-7226-49e4-88d4-4b4fcb2b02f7" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeTenMember"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeTenMember_61af9fab-7226-49e4-88d4-4b4fcb2b02f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_ExercisePriceRangeEightMember_44f85ca7-81ef-4aa7-b1f3-6063ca488ad4" xlink:href="lgnd-20181231.xsd#lgnd_ExercisePriceRangeEightMember"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_lgnd_ExercisePriceRangeElevenMember_59e1f75f-75e6-485f-bdd6-0f098beeda61" xlink:to="loc_lgnd_ExercisePriceRangeEightMember_44f85ca7-81ef-4aa7-b1f3-6063ca488ad4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_96a444e4-b10a-4da0-9eb3-b26e4cdd6c9c" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_58fb6c7f-f445-4403-9a8c-3a91902d5be7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit_58fb6c7f-f445-4403-9a8c-3a91902d5be7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_bb3a7594-a8bd-420e-82de-fdc81f457d42" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit_bb3a7594-a8bd-420e-82de-fdc81f457d42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_747c884f-2e25-42e4-8bab-901dd9827d59" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions_747c884f-2e25-42e4-8bab-901dd9827d59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_ec97dde9-0db0-4ee4-bb85-6c03168a4119" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2_ec97dde9-0db0-4ee4-bb85-6c03168a4119" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_32cfa971-c05c-4948-8b74-9749e94d3c04" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1_32cfa971-c05c-4948-8b74-9749e94d3c04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_5baeb87a-22f8-48f6-9063-8dede27f4cd5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions_5baeb87a-22f8-48f6-9063-8dede27f4cd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_339e76b0-5078-4080-b8c8-b5a579fd9de3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_6c2b3d17-f275-484f-82dc-b26b094b930b" xlink:to="loc_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1_339e76b0-5078-4080-b8c8-b5a579fd9de3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityAssumptionsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityAssumptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_edd60654-f699-42e6-9c3a-d6cc1561058a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_edd60654-f699-42e6-9c3a-d6cc1561058a" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:to="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_68c4dc5d-08c3-4fa0-bdc5-89e822cd425c" xlink:to="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_247bb733-53fd-4101-b922-b9d9e44b15a9" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:to="loc_srt_MinimumMember_247bb733-53fd-4101-b922-b9d9e44b15a9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_799c4478-7381-4f64-b606-9db77eecf010" xlink:href="http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_acd45183-afa7-4c1a-a9ac-fcaa1d426592" xlink:to="loc_srt_MaximumMember_799c4478-7381-4f64-b606-9db77eecf010" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_4943314d-7230-4319-a3b4-b1e84b8eb4ca" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e3d9c2bd-060b-40de-8ab0-e123676b0927" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_e3d9c2bd-060b-40de-8ab0-e123676b0927" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6dc8284b-b682-47af-9ffb-5c5fb2151929" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_6dc8284b-b682-47af-9ffb-5c5fb2151929" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ba910226-25f2-4336-bf0c-7a7ef5a19b31" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_0a6897c9-d205-421c-992a-bd8324eaeb71" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_ba910226-25f2-4336-bf0c-7a7ef5a19b31" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#StockholdersEquityRestrictedStockActivityDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_2a744778-9616-4546-a297-7243f5a352bc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_2a744778-9616-4546-a297-7243f5a352bc" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:to="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_5070a118-0a5b-465e-87d9-a925ce827505" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedStockMember_940fbb54-31a8-4354-9a6b-4d8228d5f380" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RestrictedStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_b1779d63-0d49-4fb1-8b81-5b9b2efa6de5" xlink:to="loc_us-gaap_RestrictedStockMember_940fbb54-31a8-4354-9a6b-4d8228d5f380" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_487bf369-cab8-4b84-b922-b2274100e131" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38d57b2d-1d71-4c33-b62c-e971157ee83e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_38d57b2d-1d71-4c33-b62c-e971157ee83e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_98b80bd0-b50c-4a58-a049-d493878b0ad8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod_98b80bd0-b50c-4a58-a049-d493878b0ad8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_7635d218-1f84-4602-a089-a7476122960a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod_7635d218-1f84-4602-a089-a7476122960a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_d53886f1-0548-4c49-b4a3-578528c15364" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod_d53886f1-0548-4c49-b4a3-578528c15364" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d2c28728-6afb-4a48-a966-15dce369ea83" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward_d5640229-e284-4f2d-84af-76e30b11c55e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber_d2c28728-6afb-4a48-a966-15dce369ea83" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_97d8c28a-ab83-4110-a62a-11f41cf78d4d" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e68f6c8a-1b89-4149-8996-a63f9b49cc18" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_e68f6c8a-1b89-4149-8996-a63f9b49cc18" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7b6e6be4-b6bb-441e-9a5f-0f164547be25" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue_7b6e6be4-b6bb-441e-9a5f-0f164547be25" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_b01c6716-d7d5-4d89-b740-f8f022a4d1ea" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue_b01c6716-d7d5-4d89-b740-f8f022a4d1ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_c06fe0d1-a17d-47fd-8851-e84cca3663c5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue_c06fe0d1-a17d-47fd-8851-e84cca3663c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_31bd0f0c-2ff5-4060-91bd-6d15ec43feca" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward_8099d114-b725-43b0-a05e-19d02b05cfc6" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue_31bd0f0c-2ff5-4060-91bd-6d15ec43feca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="simple" xlink:href="lgnd-20181231.xsd#CommitmentsandContingenciesLegalProceedings"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_3c38dad1-7896-4bde-a4a6-cc1edde4fdcc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LegalMattersAndContingenciesTextBlock_67456b18-e58f-483d-86ca-d0571cfcfabb" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_LegalMattersAndContingenciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_3c38dad1-7896-4bde-a4a6-cc1edde4fdcc" xlink:to="loc_us-gaap_LegalMattersAndContingenciesTextBlock_67456b18-e58f-483d-86ca-d0571cfcfabb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxes" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_9de3a1c2-73be-4e1d-bf64-7cb2d6e5ae60" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_2ccbecd7-d49c-4845-8406-c20c08863ddf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_9de3a1c2-73be-4e1d-bf64-7cb2d6e5ae60" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_2ccbecd7-d49c-4845-8406-c20c08863ddf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_3423e27b-3e8c-43de-ad80-56c8c3d4c8b6" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_a011a12f-4885-484c-901e-b0a307d31b9c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_3423e27b-3e8c-43de-ad80-56c8c3d4c8b6" xlink:to="loc_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock_a011a12f-4885-484c-901e-b0a307d31b9c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_f0458ecd-9f33-42f1-b145-74274ab1fa1c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_3423e27b-3e8c-43de-ad80-56c8c3d4c8b6" xlink:to="loc_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock_f0458ecd-9f33-42f1-b145-74274ab1fa1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_d75e66d2-b424-45a4-8170-1b44de8f6587" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_3423e27b-3e8c-43de-ad80-56c8c3d4c8b6" xlink:to="loc_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock_d75e66d2-b424-45a4-8170-1b44de8f6587" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock_4d57899f-deed-4053-98f1-5616545eaefc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_3423e27b-3e8c-43de-ad80-56c8c3d4c8b6" xlink:to="loc_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock_4d57899f-deed-4053-98f1-5616545eaefc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_b6e12c22-9632-4bff-97cd-559cd5fd3d81" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_b6e12c22-9632-4bff-97cd-559cd5fd3d81" xlink:to="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:to="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxAuthorityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityAxis_5b3c0db2-e888-4d3a-89c2-c9678eab0a02" xlink:to="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InternalRevenueServiceIRSMember_7a72e856-d986-45a0-b1c9-b8385b215102" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_InternalRevenueServiceIRSMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:to="loc_us-gaap_InternalRevenueServiceIRSMember_7a72e856-d986-45a0-b1c9-b8385b215102" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StateAndLocalJurisdictionMember_c84cb97d-fe91-4adf-a35d-b4130a1b6295" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_StateAndLocalJurisdictionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxAuthorityDomain_05ab5692-a8be-4e4a-974a-ece20156c993" xlink:to="loc_us-gaap_StateAndLocalJurisdictionMember_c84cb97d-fe91-4adf-a35d-b4130a1b6295" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:to="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardAxis_0fb5c98e-8efb-4aa7-9a31-726942c34bd7" xlink:to="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchMember_b12f76d6-b1a8-4654-a511-57bf2049cbec" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ResearchMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:to="loc_us-gaap_ResearchMember_b12f76d6-b1a8-4654-a511-57bf2049cbec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_d58de77d-723c-4ca3-9ff6-021463286742" xlink:href="lgnd-20181231.xsd#lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TaxCreditCarryforwardNameDomain_a3a6a513-153d-4363-9874-f9635dfc8bd4" xlink:to="loc_lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember_d58de77d-723c-4ca3-9ff6-021463286742" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwardsLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsTable_533e0276-69ae-4de4-a0db-6e0cafc04491" xlink:to="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_683ee185-ce2f-4860-a914-2243851ccddb" xlink:href="lgnd-20181231.xsd#lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit_683ee185-ce2f-4860-a914-2243851ccddb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_6bad2dce-d194-42be-9aa0-66d90592701b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount_6bad2dce-d194-42be-9aa0-66d90592701b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLossCarryforwards_be58294f-6aa1-4964-9ffb-d95cb8cc9ab8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingLossCarryforwards"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_OperatingLossCarryforwards_be58294f-6aa1-4964-9ffb-d95cb8cc9ab8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxCreditCarryforwardAmount_791838bd-2a5b-44c0-8306-9b43ba2fb852" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_TaxCreditCarryforwardAmount"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_TaxCreditCarryforwardAmount_791838bd-2a5b-44c0-8306-9b43ba2fb852" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_a531ec9d-376d-47e6-90f2-1fe6d5301f20" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingLossCarryforwardsLineItems_42e8249b-d179-4672-880a-b96a8c358714" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate_a531ec9d-376d-47e6-90f2-1fe6d5301f20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_78ed39c5-a2b8-4806-8260-705230bf0c06" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_78ed39c5-a2b8-4806-8260-705230bf0c06" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentFederalTaxExpenseBenefit_f37a1118-53af-4eb2-9267-6e244395cf73" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentFederalTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:to="loc_us-gaap_CurrentFederalTaxExpenseBenefit_f37a1118-53af-4eb2-9267-6e244395cf73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_1ee55178-97d2-4c2d-8a4f-1df108d43b78" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentStateAndLocalTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:to="loc_us-gaap_CurrentStateAndLocalTaxExpenseBenefit_1ee55178-97d2-4c2d-8a4f-1df108d43b78" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentForeignTaxExpenseBenefit_6a339223-c9ce-4eca-9d9a-16f6bd4969d5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentForeignTaxExpenseBenefit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:to="loc_us-gaap_CurrentForeignTaxExpenseBenefit_6a339223-c9ce-4eca-9d9a-16f6bd4969d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_3acc371b-5359-440a-a00e-595ab721d70e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_CurrentIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract_100b2cfb-9759-4092-bf04-db4cbad1f48b" xlink:to="loc_us-gaap_CurrentIncomeTaxExpenseBenefit_3acc371b-5359-440a-a00e-595ab721d70e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_1ca27079-72ca-48ba-944a-2101696f6947" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_78ed39c5-a2b8-4806-8260-705230bf0c06" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_1ca27079-72ca-48ba-944a-2101696f6947" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_4731dc73-2249-4f7d-b11d-ef07df9d2aee" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredFederalIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_1ca27079-72ca-48ba-944a-2101696f6947" xlink:to="loc_us-gaap_DeferredFederalIncomeTaxExpenseBenefit_4731dc73-2249-4f7d-b11d-ef07df9d2aee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_23e7910a-95e1-46f3-91b1-5301752e098f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_1ca27079-72ca-48ba-944a-2101696f6947" xlink:to="loc_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit_23e7910a-95e1-46f3-91b1-5301752e098f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7cc37439-151c-4264-871e-603b5c30e5b8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredForeignIncomeTaxExpenseBenefit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract_1ca27079-72ca-48ba-944a-2101696f6947" xlink:to="loc_us-gaap_DeferredForeignIncomeTaxExpenseBenefit_7cc37439-151c-4264-871e-603b5c30e5b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_a6a526b3-4a95-4669-87a1-b54e9ba09d85" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_78ed39c5-a2b8-4806-8260-705230bf0c06" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_a6a526b3-4a95-4669-87a1-b54e9ba09d85" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_958218e7-9f31-44c6-81ac-746e185556ad" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_958218e7-9f31-44c6-81ac-746e185556ad" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_fee25cb4-d469-498e-9385-d29a82529203" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate_fee25cb4-d469-498e-9385-d29a82529203" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_611486ba-1443-44a0-9473-db383148ffd0" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes_611486ba-1443-44a0-9473-db383148ffd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationContingentValueRights_05175e8c-fae3-418a-9e3a-81e7bab13e1f" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationContingentValueRights"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_lgnd_IncomeTaxReconciliationContingentValueRights_05175e8c-fae3-418a-9e3a-81e7bab13e1f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_48427153-0a37-4f1e-a264-203bcdaa0350" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost_48427153-0a37-4f1e-a264-203bcdaa0350" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_4e50b1dd-5524-4ee6-80f6-37ee9c95024e" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch_4e50b1dd-5524-4ee6-80f6-37ee9c95024e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_7fb11bf2-fe80-4ba9-9595-e10ccc28f2fb" xlink:href="lgnd-20181231.xsd#lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions_7fb11bf2-fe80-4ba9-9595-e10ccc28f2fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_cae4121a-b6b5-40b4-b007-0c7d4f7304a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate_cae4121a-b6b5-40b4-b007-0c7d4f7304a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_4e21b79c-5feb-473f-b55d-bde3649606ef" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance_4e21b79c-5feb-473f-b55d-bde3649606ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther_027910cf-fe58-4309-a1aa-6b1a776f67b5" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationTaxCreditsOther"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationTaxCreditsOther_027910cf-fe58-4309-a1aa-6b1a776f67b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_332b0cd5-8d11-404c-82d7-787f6e6c3a75" xlink:href="lgnd-20181231.xsd#lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives_332b0cd5-8d11-404c-82d7-787f6e6c3a75" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_d1839686-54e2-45b3-96f1-db4b8f9b595f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxReconciliationOtherAdjustments"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxReconciliationOtherAdjustments_d1839686-54e2-45b3-96f1-db4b8f9b595f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_e1a89f8c-6aea-4815-b83e-c2e3ba2634cf" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract_bc5ba3b3-ebe3-4ed7-88bc-1014909ab280" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_e1a89f8c-6aea-4815-b83e-c2e3ba2634cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesDeferredTaxesDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_492c3c64-fd2a-4a08-aa76-87296624064f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGrossAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_492c3c64-fd2a-4a08-aa76-87296624064f" xlink:to="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_118da01f-80e7-43f1-8d65-75d712bb9fbe" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOperatingLossCarryforwards"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards_118da01f-80e7-43f1-8d65-75d712bb9fbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_11d78635-2631-4e49-bc4d-b6990540ae70" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxCreditCarryforwards"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards_11d78635-2631-4e49-bc4d-b6990540ae70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_b35963a5-9a9e-407b-a6ba-66cfb08476ab" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets_b35963a5-9a9e-407b-a6ba-66cfb08476ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_81be92d8-6ce7-4c2d-adfa-24570b4465a4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities_81be92d8-6ce7-4c2d-adfa-24570b4465a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsDeferredIncome_b9c8fa14-ba5d-4d10-b82e-994bd1e1cea8" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsDeferredIncome"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsDeferredIncome_b9c8fa14-ba5d-4d10-b82e-994bd1e1cea8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_5fdbdfa2-9dde-4149-bcb9-449916a009e3" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsCapitalLossCarryforwards"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards_5fdbdfa2-9dde-4149-bcb9-449916a009e3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_824329e4-4cac-400f-b8b4-81a8976ce82d" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsEquityMethodInvestments"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsEquityMethodInvestments_824329e4-4cac-400f-b8b4-81a8976ce82d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsOther_4bc66601-8cf6-4714-8196-c09cf27f479f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsOther"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsOther_4bc66601-8cf6-4714-8196-c09cf27f479f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsGross_a69ce358-1b48-410e-853b-3acd88c700aa" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsGross"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsGross_a69ce358-1b48-410e-853b-3acd88c700aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4e199aac-5948-4620-8328-c06aa9451717" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsValuationAllowance"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsValuationAllowance_4e199aac-5948-4620-8328-c06aa9451717" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsNet_90e9e684-b20b-448e-8da2-a94427549815" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsNet"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxAssetsGrossAbstract_4ec75001-2d6e-4321-9e4a-38ea328ee26b" xlink:to="loc_us-gaap_DeferredTaxAssetsNet_90e9e684-b20b-448e-8da2-a94427549815" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_492c3c64-fd2a-4a08-aa76-87296624064f" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_c0cda419-0f7c-4c2b-95dc-24cf62d975ae" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFairValueAdjustment"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_lgnd_DeferredTaxLiabilitiesFairValueAdjustment_c0cda419-0f7c-4c2b-95dc-24cf62d975ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_e2fe8e29-61de-4e87-bcd0-f0213258ff6f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesFinancingArrangements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesFinancingArrangements_e2fe8e29-61de-4e87-bcd0-f0213258ff6f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_0bdfc7a1-27a6-4cd1-9048-a6c73a582737" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets_0bdfc7a1-27a6-4cd1-9048-a6c73a582737" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_29ae29a9-1447-496c-9b2b-bea295a6e379" xlink:href="lgnd-20181231.xsd#lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets_29ae29a9-1447-496c-9b2b-bea295a6e379" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxLiabilitiesInvestments_de6dbe7d-2650-4168-80fb-857e24b680f4" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxLiabilitiesInvestments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_us-gaap_DeferredTaxLiabilitiesInvestments_de6dbe7d-2650-4168-80fb-857e24b680f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxLiabilities_fdbf6acb-e818-42a0-adec-da099c3dfd28" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredIncomeTaxLiabilities"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_us-gaap_DeferredIncomeTaxLiabilities_fdbf6acb-e818-42a0-adec-da099c3dfd28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTotalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_6672497d-94fc-4ada-8c99-57ff989b8647" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_DeferredTaxAssetsLiabilitiesNet"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DeferredTaxLiabilitiesAbstract_03ad8639-1ef4-46c6-ba2c-1183f9258027" xlink:to="loc_us-gaap_DeferredTaxAssetsLiabilitiesNet_6672497d-94fc-4ada-8c99-57ff989b8647" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_8bd71494-a605-4b5b-92ae-790444c1d5be" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_8bd71494-a605-4b5b-92ae-790444c1d5be" xlink:to="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_3640b5e9-9d58-49dc-9008-2a63dca4fb4b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_3640b5e9-9d58-49dc-9008-2a63dca4fb4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_4ff168ad-4964-49c2-b9cc-1ded7098addc" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions_4ff168ad-4964-49c2-b9cc-1ded7098addc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_3bf242d9-d2f3-4064-b9c5-e6ff885f10ab" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions_3bf242d9-d2f3-4064-b9c5-e6ff885f10ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_33097def-889b-4aa2-9175-7caa7ef1181b" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:to="loc_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions_33097def-889b-4aa2-9175-7caa7ef1181b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UnrecognizedTaxBenefits_bb26c9a5-bbe7-4ee0-a3dc-c5d0407c4b94" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_UnrecognizedTaxBenefits"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward_c025c3c6-1b1a-4241-bc61-de94250aa887" xlink:to="loc_us-gaap_UnrecognizedTaxBenefits_bb26c9a5-bbe7-4ee0-a3dc-c5d0407c4b94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformation"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_97815241-1c72-43dc-89df-7ff91939cc57" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationTextBlock_d1b18408-75f0-48ac-8414-39e93606b06e" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_97815241-1c72-43dc-89df-7ff91939cc57" xlink:to="loc_us-gaap_QuarterlyFinancialInformationTextBlock_d1b18408-75f0-48ac-8414-39e93606b06e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationTables"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_bdc9044b-89da-45d1-be17-112090236468" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_5b1f82bc-e2a7-4886-a0e7-ad2403b1d9ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_bdc9044b-89da-45d1-be17-112090236468" xlink:to="loc_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock_5b1f82bc-e2a7-4886-a0e7-ad2403b1d9ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="simple" xlink:href="lgnd-20181231.xsd#SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"/>
  <link:presentationLink xlink:role="http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_QuarterlyFinancialInformationDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_83b403e1-d278-4da0-b442-345e325ce46c" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_83b403e1-d278-4da0-b442-345e325ce46c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingCostsAndExpenses_dd975810-f1b6-4dc2-b094-be524952c2db" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_OperatingCostsAndExpenses"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_OperatingCostsAndExpenses_dd975810-f1b6-4dc2-b094-be524952c2db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_2e7d1f4c-713c-4516-b1da-37f2ea347bcd" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_2e7d1f4c-713c-4516-b1da-37f2ea347bcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_36721f96-ac5a-4b29-8eef-e49ae38fd9ed" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_NetIncomeLoss_36721f96-ac5a-4b29-8eef-e49ae38fd9ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasicAbstract_7f2be2e6-afaf-4a68-8b22-36f456c0f18a" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasicAbstract"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_EarningsPerShareBasicAbstract_7f2be2e6-afaf-4a68-8b22-36f456c0f18a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e10a4216-5ee6-4563-ac06-301a542468a1" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareBasicAbstract_7f2be2e6-afaf-4a68-8b22-36f456c0f18a" xlink:to="loc_us-gaap_EarningsPerShareBasic_e10a4216-5ee6-4563-ac06-301a542468a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDilutedAbstract_dbd30c87-837d-4524-b504-9ff8dd14e45f" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDilutedAbstract"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_EarningsPerShareDilutedAbstract_dbd30c87-837d-4524-b504-9ff8dd14e45f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_fd2bec4a-c616-4e1a-a1a6-cd278bc43d49" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EarningsPerShareDilutedAbstract_dbd30c87-837d-4524-b504-9ff8dd14e45f" xlink:to="loc_us-gaap_EarningsPerShareDiluted_fd2bec4a-c616-4e1a-a1a6-cd278bc43d49" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_06a4c512-3cd3-4ab2-a70a-b44de4042d16" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_06a4c512-3cd3-4ab2-a70a-b44de4042d16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_90068e87-8264-4425-b403-23982cd800ae" xlink:href="http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_QuarterlyFinancialInformationDisclosureAbstract_fa105e81-0a78-4779-a83d-2e03fe73641c" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_90068e87-8264-4425-b403-23982cd800ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>13
<FILENAME>lgnd-20181231_g1.gif
<TEXT>
begin 644 lgnd-20181231_g1.gif
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*\>DI! HA 0$ .P$!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>14
<FILENAME>lgnd-20181231_g2.jpg
<TEXT>
begin 644 lgnd-20181231_g2.jpg
M_]C_X  02D9)1@ ! 0$ 8 !@  #_VP!#  ," @," @,# P,$ P,$!0@%!00$
M!0H'!P8(# H,# L*"PL-#A(0#0X1#@L+$!80$1,4%145# \7&!84&!(4%13_
MVP!# 0,$! 4$!0D%!0D4#0L-%!04%!04%!04%!04%!04%!04%!04%!04%!04
M%!04%!04%!04%!04%!04%!04%!04%!3_P  1" +_!C # 2(  A$! Q$!_\0
M'P   04! 0$! 0$           $" P0%!@<("0H+_\0 M1   @$# P($ P4%
M! 0   %] 0(#  01!1(A,4$&$U%A!R)Q%#*!D:$((T*QP152T? D,V)R@@D*
M%A<8&1HE)B<H*2HT-38W.#DZ0T1%1D=(24I35%565UA96F-D969G:&EJ<W1U
M=G=X>7J#A(6&AXB)BI*3E)66EYB9FJ*CI*6FIZBIJK*SM+6VM[BYNL+#Q,7&
MQ\C)RM+3U-76U]C9VN'BX^3EYN?HZ>KQ\O/T]?;W^/GZ_\0 'P$  P$! 0$!
M 0$! 0        $" P0%!@<("0H+_\0 M1$  @$"! 0#! <%! 0  0)W  $"
M Q$$!2$Q!A)!40=A<1,B,H$(%$*1H;'!"2,S4O 58G+1"A8D-.$E\1<8&1HF
M)R@I*C4V-S@Y.D-$149'2$E*4U155E=865IC9&5F9VAI:G-T=79W>'EZ@H.$
MA8:'B(F*DI.4E9:7F)F:HJ.DI::GJ*FJLK.TM;:WN+FZPL/$Q<;'R,G*TM/4
MU=;7V-G:XN/DY>;GZ.GJ\O/T]?;W^/GZ_]H # ,!  (1 Q$ /P#]4Z*** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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MLIC!$DUI:&9IA$8_G\S;@C* $D@8^6N?^*'[9 ^&T/QVD/A'^T!\+XM*E/\
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M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BB
MB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
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M_!/Q=X&^U"PGU>S*6UT>D-PC"2%SP>!(B$XYP#CFO XOVO\ XM:'X:3PM?\
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M5#!E)W*P'5ZQKFG>';$WNJZA:Z99"2.(W%Y,L,8>1U2-=S$#+.RJ!W+ #DT
M?EGIO@&Z\0?&OX)^(_#/P8^-D,6C>*K)M;\6_$N2ZGO55B?E6W+N!".'>X"J
MJ[ #C//VO^R7X9UCPWK7QT?5M)OM+34?B+J-]9->VSPBZMV@M@LT18#?&2K
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB
M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** ,7Q=XU\/?#_19-8\4:]IGAO2(V5'O]7O([6!68X4&21@
MH)/ &>:Y[PC\>OAG\0-632O"_P 1?"?B35'!9;+2-<M;J9@ 22$C<MP 3T[&
MO(/^"A%C;:I\#=%LKVWBN[.X\8Z##-;SH'CE1K^(,C*>"I!((/!!JK^TK^Q]
M\)9O@KXJU3P_X%T#P3XDT*QFUK2M>\,Z7!87=I=6R&6)P\2J6&Y!E3QSV(!
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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M!XI^%'@OQ]X6T[X)^)+RZE>XO[2=]>TJUNI&DN;2V"CR70EW 9R& D;!! H
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MNO\ XU7JM% 'E7_#47PQ_P"AF_\ )"Z_^-4?\-1?#'_H9O\ R0NO_C5>JT4
M>5?\-1?#'_H9O_)"Z_\ C5'_  U%\,?^AF_\D+K_ .-5ZK10!Y5_PU%\,?\
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M_P D+K_XU1_PU%\,?^AF_P#)"Z_^-5ZK10!Y5_PU%\,?^AF_\D+K_P"-4?\
M#47PQ_Z&;_R0NO\ XU7JM% 'E7_#47PQ_P"AF_\ )"Z_^-4?\-1?#'_H9O\
MR0NO_C5>JT4 >5?\-1?#'_H9O_)"Z_\ C5'_  U%\,?^AF_\D+K_ .-5ZK10
M!Y5_PU%\,?\ H9O_ "0NO_C5'_#47PQ_Z&;_ ,D+K_XU7JM% 'E7_#47PQ_Z
M&;_R0NO_ (U1_P -1?#'_H9O_)"Z_P#C5>JT4 >5?\-1?#'_ *&;_P D+K_X
MU1_PU%\,?^AF_P#)"Z_^-5ZK10!Y5_PU%\,?^AF_\D+K_P"-4?\ #47PQ_Z&
M;_R0NO\ XU7JM% 'E7_#47PQ_P"AF_\ )"Z_^-4?\-1?#'_H9O\ R0NO_C5>
MJT4 >5?\-1?#'_H9O_)"Z_\ C5'_  U%\,?^AF_\D+K_ .-5ZK10!Y5_PU%\
M,?\ H9O_ "0NO_C5'_#47PQ_Z&;_ ,D+K_XU7JM% 'E7_#47PQ_Z&;_R0NO_
M (U1_P -1?#'_H9O_)"Z_P#C5>JT4 >5?\-1?#'_ *&;_P D+K_XU1_PU%\,
M?^AF_P#)"Z_^-5ZK10!Y5_PU%\,?^AF_\D+K_P"-4?\ #47PQ_Z&;_R0NO\
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M_P"AF_\ )"Z_^-4?\-1?#'_H9O\ R0NO_C5>JT4 >5?\-1?#'_H9O_)"Z_\
MC5'_  U%\,?^AF_\D+K_ .-5ZK10!Y5_PU%\,?\ H9O_ "0NO_C5'_#47PQ_
MZ&;_ ,D+K_XU7JM% 'E7_#47PQ_Z&;_R0NO_ (U1_P -1?#'_H9O_)"Z_P#C
M5>JT4 >5?\-1?#'_ *&;_P D+K_XU1_PU%\,?^AF_P#)"Z_^-5ZK10!Y5_PU
M%\,?^AF_\D+K_P"-4?\ #47PQ_Z&;_R0NO\ XU7JM% 'E7_#47PQ_P"AF_\
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M0 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 44
M44 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !111
M0 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 44
M44 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !111
M0 5Y5\?/^:<_]CGIO_M2O5:\J^/G_-.?^QSTW_VI0!ZK1110 4444 %%%% !
M1110 4444 %%%% !7E7[6/\ R:S\9/\ L3-9_P#2&:O5:\J_:Q_Y-9^,G_8F
M:S_Z0S4 =5\)_P#DEG@W_L#6?_HA*ZNN4^$__)+/!O\ V!K/_P!$)75T %%%
M% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
M %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
M4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1
M110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%
M% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
M %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
M4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1
M110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %>5
M?'S_ )IS_P!CGIO_ +4KU6O*OCY_S3G_ +'/3?\ VI0!ZK1110 4444 %%%%
M !1110 4444 %%%% !7E7[6/_)K/QD_[$S6?_2&:O5:\J_:Q_P"36?C)_P!B
M9K/_ *0S4 =5\)_^26>#?^P-9_\ HA*ZNN4^$_\ R2SP;_V!K/\ ]$)75T %
M%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 44
M44 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !111
M0 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 44
M44 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !111
M0 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M>5?'S_FG/_8YZ;_[4KU6O*OCY_S3G_L<]-_]J4 >JT444 %%%% !1110 444
M4 %%%% !1110 5Y5^UC_ ,FL_&3_ +$S6?\ TAFKU6O*OVL?^36?C)_V)FL_
M^D,U '5?"?\ Y)9X-_[ UG_Z(2NKKE/A/_R2SP;_ -@:S_\ 1"5U= !1110
M4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1
M110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%
M% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
M %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
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M,CE5QF/RM@)D+#E0@)/8&L_X,?M ?#[]H70+C6?A[XGM?$EC;2^3<>5')#+
MQS@212JLB9P<%E .#C-?#?P%4>+]/_8V\,:U,-5T2QU/Q5/%;W1:1)'TYY8K
M)B&')B4Y7(&-HQCI7T79Z?;>&O\ @HM=?V8D=H/$GPZ-[JL4(*BYN+>_2*&9
MP.&<1R,FXY.T <#J ?3=>5?M8_\ )K/QD_[$S6?_ $AFKU6OFW]K;XV>'H?@
M)\8_#K:=XN.H'POK%EYR^#-8:R\PVDJAOM8M?(\O)_UOF; .2V.: /9_A/\
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M(?\ Y!H_X:6\(_\ 0(^('_AN/$/_ ,@T >JT5Y5_PTMX1_Z!'Q _\-QXA_\
MD&C_ (:6\(_] CX@?^&X\0__ "#0!ZK17E7_  TMX1_Z!'Q _P##<>(?_D&C
M_AI;PC_T"/B!_P"&X\0__(- 'JM%>5?\-+>$?^@1\0/_  W'B'_Y!H_X:6\(
M_P#0(^('_AN/$/\ \@T >JT5Y5_PTMX1_P"@1\0/_#<>(?\ Y!H_X:6\(_\
M0(^('_AN/$/_ ,@T >JT5Y5_PTMX1_Z!'Q _\-QXA_\ D&C_ (:6\(_] CX@
M?^&X\0__ "#0!ZK17E7_  TMX1_Z!'Q _P##<>(?_D&C_AI;PC_T"/B!_P"&
MX\0__(- 'JM%>5?\-+>$?^@1\0/_  W'B'_Y!H_X:6\(_P#0(^('_AN/$/\
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M'Q _\-QXA_\ D&C_ (:6\(_] CX@?^&X\0__ "#0!ZK17E7_  TMX1_Z!'Q
M_P##<>(?_D&C_AI;PC_T"/B!_P"&X\0__(- 'JM%>5?\-+>$?^@1\0/_  W'
MB'_Y!H_X:6\(_P#0(^('_AN/$/\ \@T >JT5Y5_PTMX1_P"@1\0/_#<>(?\
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M_(- 'JM%>5?\-+>$?^@1\0/_  W'B'_Y!H_X:6\(_P#0(^('_AN/$/\ \@T
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M "#0!ZK17E7_  TMX1_Z!'Q _P##<>(?_D&C_AI;PC_T"/B!_P"&X\0__(-
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M\-+>$?\ H$?$#_PW'B'_ .0:/^&EO"/_ $"/B!_X;CQ#_P#(-5SR[CNSLO\
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M?UBM_._O8<TNXY_V7OA=(C*?"5N PP=MQ.#^8?BJG_#)?PI_Z%7_ ,J-W_\
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHILDB0QO)(RQQ
MH"S,QP !U)- #J0G')X%>%?$S]K[P;X'\VUTASXHU1>-EDX%NI_VIN0?^ AO
MPKYXU#QQ\7OVFKZ6QTR&X722VV2UT\&"SC'I+(3\W'.&8].!7HTL#4J+GG[L
M>[-HTI/5Z(^F/B9^U7X)^'GFVT%U_P )%JR<?8].<,BMZ/+]U?<#<1Z5\VZU
M\8OBQ^T1J,ND>'K6XMK!N'L](!1%4]/.G)''U*J?2O5OAG^Q#I&D^5>>,[XZ
MS=##?V?9EH[93Z,_#O\ AM_&OI+1=!T[PWIT5AI5C;Z=91#"6]K&(T'O@=_>
MM_;8;"_PH\\N[V_K^KE<T(?"KL^7/AG^PY;6_E7OCC4OM3\-_9>G,53Z/+U/
MT4#_ 'C7TYX:\)Z-X-TU-/T/3+;2[-?^65M&%!/J3U8^YYK6HK@K8FK7?OLR
ME.4MV%%%%<Q 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
M4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1
M110 4444 %%%% !7E7Q\_P":<_\ 8YZ;_P"U*]5KRKX^?\TY_P"QSTW_ -J4
M >JT444 %%%% !1110 4444 %%%% !1110 5Y5^UC_R:S\9/^Q,UG_TAFKU6
MO*OVL?\ DUGXR?\ 8F:S_P"D,U '5?"?_DEG@W_L#6?_ *(2NKKE/A/_ ,DL
M\&_]@:S_ /1"5U= !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 44
M44 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !111
M0 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
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MI6=ZCN8RDY;A1116!(4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %
M%%% !1110 4444 %%%% !1110 4444 %>5?'S_FG/_8YZ;_[4KU6O*OCY_S3
MG_L<]-_]J4 >JT444 %%%% !1110 4444 %%%% !1110 5Y5^UC_ ,FL_&3_
M +$S6?\ TAFKU6O*OVL?^36?C)_V)FL_^D,U '5?"?\ Y)9X-_[ UG_Z(2NK
MKE/A/_R2SP;_ -@:S_\ 1"5U= !1110 4444 %%%% !1110 4444 %%%% !1
M110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%
M% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
M %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110
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M1110 4444 %>5?'S_FG/_8YZ;_[4KU6O*OCY_P TY_['/3?_ &I0!ZK1110
M4444 %%%% !1110 4444 %%%% !7E7[6/_)K/QD_[$S6?_2&:O5:\J_:Q_Y-
M9^,G_8F:S_Z0S4 =5\)_^26>#?\ L#6?_HA*ZNN4^$__ "2SP;_V!K/_ -$)
M75T %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !11
M10 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
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M3\0/_ [P]_\ +6O5:* /*O\ A<GB[_HA/Q _\#O#W_RUH_X7)XN_Z(3\0/\
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MK_A<GB[_ *(3\0/_  .\/?\ RUH_X7)XN_Z(3\0/_ [P]_\ +6O5:* /*O\
MA<GB[_HA/Q _\#O#W_RUH_X7)XN_Z(3\0/\ P.\/?_+6O5:* /*O^%R>+O\
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MQ _\#O#W_P M:]5HH \J_P"%R>+O^B$_$#_P.\/?_+6C_A<GB[_HA/Q _P#
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ML6NH;,8/7RY .CC\F R.X'%^ _ >L_$CQ+;:'H=L;B[F.68\1PH.LCGLH_P
MR2!7ZA>(_#FF^+M$N](U>TCOM/NDV2PR#@CU'H0>01R" 17-?"WX/^'?A#I,
M]EH4$A>X??/>73!YY>3M#, .%!P  !U/4DGUH9JU2M)7F;JO[NNY>^&/@>/X
M;^!=)\.1W37OV&(JUPZA3(Q8L3@=!DX'4X Y-=3117@2DY-R>[.5N[NPHHHJ
M1!1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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M9X-_[ UG_P"B$KJZ "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
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M !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
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M//PZ901XTT7!YYO$']:\6;]@CP_N.WQ3J07/ ,$9-4S^P'I_;QG<X_Z\%_\
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MN/$05L?4S#^='UJIUI,/[#PK^'&P_+]3[MHKX2_X5W^TKIO[S[7XD?=\N/\
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M](9J]5KRK]K'_DUGXR?]B9K/_I#-0!U7PG_Y)9X-_P"P-9_^B$KJZY3X3_\
M)+/!O_8&L_\ T0E=70 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHJGJFL6&AVC76I7MOI]JOWIKJ58D'U9B!7DGB[]KGX;^%=Z1:M)KERO_ "QT
MJ$R#_OMMJ'\&-9SJ0I_$['7A\'B,4[4*;EZ(]GHKXO\ %?[>&LWS-!X8\-VU
MCN.U)K^1KB0Y[A%V@'VRU<U]A_:"^-7^M_MJ&PEZ^81IUL5_W?DWC\&-<;QL
M&[4TY/R/HJ?#>)C'GQ<XTH^;U_R_$^R?%GQ8\'>!=XUSQ'I]A*G6W:8/-_W[
M7+'\J\4\6_MU>$]+\R/0-(O]<E7I+-BVA/N"<M^:BN-\)_L%W\Q27Q-XF@MA
MU:WTR(RL?;S'V@'_ (":]J\)_LH_#;PGL?\ L/\ MFX7_EMJTAGS]4XC_P#'
M:7-BJFR447[+(L'\<Y5I>6B_3\&SYPU#]JCXM?$JZ>S\*Z?]C#?*(M&L6N)@
M/]IV#8^H"TEG^R_\7OB==)>^*;\V@8Y\S6K]IY /]E%W8^AVU]SV.GVNEVJ6
MUE;0VENG"PP1A$7Z <"K%'U/GUJS;#_6!8=6P&'C3\]W]^GXW/F7PE^PGX6T
MW9)K^LW^MRCDQ6X%M"?8CYF/X,*]K\)?"+P9X%V'0_#>GV,J=+CRO,F_[^/E
MOUKKZ*ZH4*5/X8GAXG-,;B_XU5M=ME]RT"BBBMSRPHHHH **** "BBB@ HHH
MH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
M KY/_:S^!?C;XF?$/3=5\-:,-2LHM+CM9)/M4,1619I6(Q(ZGHZ\BOK"BL:U
M*-:/)(]'+\=5RZNJ]))O;7;7T:/SC_X9)^*__0J?^5&T_P#CM?1W['_PC\5_
M"U?%I\3Z7_9AO_LGV<?:(IM^SSMW^K9L8WKU]:^CJ*YJ6#IT9J<6[H]G'<1X
MO'X>6&JQBHRMLG?1W[OL%%%%=Y\J%%%% !1110 4444 %%%% !1110 5Y5\?
M/^:<_P#8YZ;_ .U*]5KRKX^?\TY_['/3?_:E 'JM%%% !1110!X;^T-^UQX/
M_9^U#P]H5U)'K?C#7-1M+*VT"UN LT44TZ1&YF(#>5&NXX+#YV 4?Q%=S]H[
MXUZC\#_!NDZCHGA4^-O$.LZS:Z'IFA+J*6!NKB<M@><Z,JX",>1CCDCK7EW[
M=GA?1]-^&^GZU::59VVL:EXT\-B]U"*!5GN1'?1+&)' W,%' !.!SCK76_M.
M?"*#XT:_\-=&/Q/_ .%>7]CJEQJEI;V*PG4]19+=HW^R-(_R/'',[%Q'(4W*
MV%(!H W?@?\ $KXJ^/+[58OB+\&_^%76UO'&UG<?\)1::O\ :V)(9=L"@Q[0
M <GKGVKR+Q/^WIJNEWGB/Q#H?P>USQ/\'O#6H2:=J_CRSU*!2C1/LGEM[(CS
M+B&-CS(K 85R<;35CX(0>+/@I^U%J_P<NOB#K_Q)\)WOA/\ X2>SN?%ET+O5
M--G6Z$#1-<!07CD#;@& QLPH'S%N9_9XU#3;'_@F'K1U!T2*ST+Q%#J2RN,K
M,)KL2J_'WB3W!SD=<T ?9VEZG::UIMIJ-A<1W=C=PI<6]Q$VY)8W4,K*>X((
M(^M?-GQ,_;"\2:'X\\4Z#\.O@_J_Q2T_P:$_X2?5['5(+-+)V3S##;QNK-=3
M+'RT:8(.%[YKTS]EF"YM?V9_A1%>!UND\*Z6L@D.6W?98\Y->;_L9W-O:S?'
M^&X=8KRW^)FLRW0D<;EC98FB8^BF/;C.>![8 !N^-_VO= T?X/\ @CQIX2T:
M]\<ZEXZDAMO#/AVQD2*XO9Y$+%)')*Q+'M82.<A"IS5[X!_M':A\5/$WB/P9
MXS\"WGPS^(>@Q0W=UX?O+^*^CFM)21'<6]Q& LJ97:Q PK';DG./D;]FJ2*W
MF_8UO)@T>E7%_P"-%LFD<;,RO,UN!QWC#!>!UQQG%?24TD5Q_P %&K5;8[I;
M;X82B\V,/EWZFAA##U^60C/J>F>0#Z5KRK]K'_DUGXR?]B9K/_I#-7JM?-O[
M6VM?%!?@)\8[>/P?X1;PS_PB^L(=1;Q7=+>_9OLDH,GV;^S2GF!<GR_.P3QO
M ^:@#V?X3_\ )+/!O_8&L_\ T0E=77@OPR\0_&A/AOX36U\ > YK8:3:"*2;
MQQ>QNR>2F"RC1V"DC&0&./4]:Z7_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X
M23XW_P#1//A__P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^
M-_\ T3SX?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)/C?_
M -$\^'__ (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW_P#1
M//A__P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\ T3SX
M?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)/C?_ -$\^'__
M (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW_P#1//A__P"%
MY??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\ T3SX?_\ A>7W
M_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)/C?_ -$\^'__ (7E]_\
M*:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW_P#1//A__P"%Y??_ "FH
M_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\ T3SX?_\ A>7W_P IJ/\
MA)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)/C?_ -$\^'__ (7E]_\ *:C_ (23
MXW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW_P#1//A__P"%Y??_ "FH_P"$D^-_
M_1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\ T3SX?_\ A>7W_P IJ/\ A)/C?_T3
MSX?_ /A>7W_RFH ]5HKRK_A)/C?_ -$\^'__ (7E]_\ *:C_ (23XW_]$\^'
M_P#X7E]_\IJ /5:*\J_X23XW_P#1//A__P"%Y??_ "FH_P"$D^-__1//A_\
M^%Y??_*:@#U6BO*O^$D^-_\ T3SX?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>
M7W_RFH ]5HKRK_A)/C?_ -$\^'__ (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_
M\IJ /5:*\J_X23XW_P#1//A__P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:
M@#U6BO*O^$D^-_\ T3SX?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]
M5HKRK_A)/C?_ -$\^'__ (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*
M\J_X23XW_P#1//A__P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O
M^$D^-_\ T3SX?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)
M/C?_ -$\^'__ (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW
M_P#1//A__P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\
MT3SX?_\ A>7W_P IJ/\ A)/C?_T3SX?_ /A>7W_RFH ]5HKRK_A)/C?_ -$\
M^'__ (7E]_\ *:C_ (23XW_]$\^'_P#X7E]_\IJ /5:*\J_X23XW_P#1//A_
M_P"%Y??_ "FH_P"$D^-__1//A_\ ^%Y??_*:@#U6BO*O^$D^-_\ T3SX?_\
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M /1//A__ .%Y??\ RFH_X23XW_\ 1//A_P#^%Y??_*:NLH]5HKRK_A)/C?\
M]$\^'_\ X7E]_P#*:C_A)/C?_P!$\^'_ /X7E]_\IJ /5:*\J_X23XW_ /1/
M/A__ .%Y??\ RFH_X23XW_\ 1//A_P#^%Y??_*:@#U6BO*O^$D^-_P#T3SX?
M_P#A>7W_ ,IJ/^$D^-__ $3SX?\ _A>7W_RFH ]5HKRK_A)/C?\ ]$\^'_\
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M_P!$\^'_ /X7E]_\IJ /5:*\J_X23XW_ /1//A__ .%Y??\ RFH_X23XW_\
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M_P#PO+[_ .4U=B2BK)'STZDZLN:;;?F>JT5Y5_PDGQO_ .B>?#__ ,+R^_\
ME-1_PDGQO_Z)Y\/_ /PO+[_Y34S,]5HKRK_A)/C?_P!$\^'_ /X7E]_\IJ/^
M$D^-_P#T3SX?_P#A>7W_ ,IJ /5:*\J_X23XW_\ 1//A_P#^%Y??_*:C_A)/
MC?\ ]$\^'_\ X7E]_P#*:@#U6BO*O^$D^-__ $3SX?\ _A>7W_RFH_X23XW_
M /1//A__ .%Y??\ RFH ]5HKRK_A)/C?_P!$\^'_ /X7E]_\IJCF\6?&JWV>
M;X!^'D6]@B[_ !]>C<QZ 9T;D^U+;<#UFBO*O^$D^-__ $3SX?\ _A>7W_RF
MH_X23XW_ /1//A__ .%Y??\ RFI@>JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JT5Y5_PDGQO_P"B>?#_ /\ "\OO_E-1
M_P ))\;_ /HGGP__ /"\OO\ Y34 >JUY5\?/^:<_]CGIO_M2C_A)/C?_ -$\
M^'__ (7E]_\ *:N*^(^K?$6^U7X?1^+O"OA?0]-'BS3VCN-$\2W.I3-+N;"&
M.33[<!=I<[MY(( VG)( /HJBBB@ HHHH XCXO?"/1_C1X9LM#UNYOK6TM-4L
M]61]/D1)#+;3+-&I+HPVEE (QG&<$=:S/CE^S_X8_: T'3K#7YM4TN^TJZ^W
M:5KF@WK6>H:;<;2OFP2KG!P>A!!X.,@8]*HH \B^!7[,?A;X"W.LZGI^I>(/
M%?BC6=BZCXG\6ZDVH:E<QIGRXVE(4!%SP%49P,YP,<#XL_X)[_#/Q=XRU75Y
MM3\6:=H&M7XU36/!.FZTT&@:I=;@QFGM0N2Q958[6494<5]-T4 <MJW@&+4O
M%GA76X-;UG28?#Z7$::+IMV(=.O5EC5 +F$+^\\L+F/D;22>:\?^+G[#?@7X
MN>-]4\42:[XO\(WFN0QVWB"U\)ZR;&UUZ)!M5+V/:WF#9E.-I(8\YYKZ)HH
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M.GX^RV=O;8Z>3$J?R%6Z/[-QL_XF*?R5OU#DEUD?-?F?%[6^<:M'N_V5MO\
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M?4&3^>*/[#^+VE_\M-6?_M]6?K_P,T?VM6C_ !,+->BO^@>T?6)]*45\U_\
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M% !1110 4444 %%%% !1110 4444 %%%% !1110 5Y5\?/\ FG/_ &.>F_\
MM2O5:\J^/G_-.?\ L<]-_P#:E 'JM%%% !1110 4444 %%%% !1110 4444
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M*2>RL@HHHK(@**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH *:Z+(I5E#*1@JPR#3J* .7UCX8^%=<W&ZT.TWMUDA3RF
M/N2F":XG5_V:]"NLMI]_>6#GHK[9D'X<']:]>HKSZV7X2O\ Q*:?RL_O1#A%
M[H^<+[]GGQ1HTWGZ3J-O<LOW6CD:"7]>!_WU5;^V_BKX)XN%U*2%/O&>(72?
MB_S?H:^F**\MY'2@[X:I*#\G_7YF?LE]EV/GO2?VF-2MR$U31[>YQP6MG:(_
MD=W/Y5VNC_M#>%=0PMT;K3'[^?#O7\"F?U KN]6\+Z/KRD:CI=I>D_Q30JS#
MZ'&17$ZO^S]X2U+<8(;G37/>VF)&?H^[],4O89MA_P"'5C-?WE;^OO"U2.SN
M=CI'C'0]>VC3]6L[MVZ1QS+O_P"^>OZ5LU\_ZO\ LR7D>YM+UJ&8=H[N(QX_
MX$N[/Y"N8O+/Q]\.3\NJR10H<!8K])4R.WEEL_\ CM+^T\90_P!YPS]8Z_U]
MY2E/;E^X^IZ*^9-%_:0\1VH47:66J)W9DV.?Q4X_2NXT?]I;1[C:NI:7=V3'
MJT++,H^OW3^AKHI9Y@:FCEROS5O^ 'M(WL]&>QT5Y?JW[2'@C28P[75]=?+N
M*VNGS.1['Y<?TKC-0_;?^'UC(R+::]<LIP1'9QK^/SR+7I1QF'DKQJ)^CN>I
MA\!BL6KT*;DO(^@Z*^7+S]O;PZBG[+X7U28X_P"6TT<?/X%JPKS]OY\D6G@A
M0,\/-J><CZ"+C\Z'C*"^U^9ZD>'<TGM1_%?YGV!17Q#>?MZ>*I%/V7PYH\)Q
MQYQEDY_!EJC_ ,-?_%G6_FL-)L54X8?8]-ED&.G\3MQ6?UZCTN_D=2X7S'>2
MBO5GW917PI_PMS]HS7/EM;'6XT;*DV_AY0N?]XPG!_$4GD_M+:[\V?$<6?F^
M_':^W3*_E2^N)_#!OY#_ -7*D?XN(IQ_[>_X"/NRBOA3_A2/[0VM?+?ZAJR*
M<J?M?B(.,'KPLK<4G_#&?Q2USG4-6TL$_,?MNH32'(X'2-N<4?6:CVI,/[%P
M<?XF.A\M?U.+^+7Q<\;VWQ2\7V]KXQURVM(-7NH88;74IHXTC29E5556
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M?A71E69?VA"7,K23_#I_D53GSDU%%%>Z:A1110 4444 %%%% !1110 4444
M%>5?'S_FG/\ V.>F_P#M2O5:\J^/G_-.?^QSTW_VI0!ZK1110 4444 %%%%
M!1110 4444 %%%% !7E7[6/_ ":S\9/^Q,UG_P!(9J]5KRK]K'_DUGXR?]B9
MK/\ Z0S4 =5\)_\ DEG@W_L#6?\ Z(2NKKE/A/\ \DL\&_\ 8&L__1"5U= !
M1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%
M%% !1110 4444 %%%% !139)$AC9Y&5$49+,< 5RFL_%?PGH>X7&M6\DB_\
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MJZY3X3_\DL\&_P#8&L__ $0E=70 4444 %%%% !1110 4444 %%%% !1110
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MTN09FSZ_/G'X5U4<:PHJ(JHBC 51@"CZCF%?_>,1RKM%?KH')-[R/FR/X/\
MC_QA()-8N6B4G.[4;LR$?15W8^G%=5HW[,MA%M;5=8N+D]3':QB,?3+;L_D*
M]KHK6GD>#@^::<WYO_AAJE'J<=H_PB\):'M,.C03R#_EI=YF)/KAL@?@*ZZ&
M&.WC6.*-8HUX"(H 'T I]%>U3HTJ*M2BH^BL:I);!139)%C1G=@B*,EF. !Z
MUA:C\0?"VCY^W^)=(LMO7[1?Q1XYQW;UK5M+<TC"<W:"N;]%>;ZA^T=\--+S
MYWC'3GQ_S[LT_P#Z #Z5R^I?ME?#&QSY.IWNH8_Y]K&09_[^!?\ (K)UJ4=Y
M+[SOIY;C:GP49/\ [=9[A17S/J/[>/@^$D66@ZU=8[S+%$#^3M7+:E^W[(P*
MV'@M4/:2YU$MV_NB,=_>L7C*"^T>A3X>S.IM1MZM+\V?8-%?#-Y^W/XZU"3R
MM.T/18"WW1Y,TTGKQ^\ Z>U0?\+W^/\ XFXTRPU)%;_H'Z#O&.G5HVQU'/TK
M/Z]2^RF_D=BX8QRUJ2C'UE_DF?9GQ$UJY\-_#_Q-J]D56\L-+NKJ!G7<HD2)
MF7([C(%? G_#6WQ7_P"AK_\ *=:?_&JW?$MO^T'K7AS5;G6CK\>CQVDLEZLT
MB6R& (3(&3*Y&T'(QSZ<\^!UYV*Q,Y-<MX_@?89'DN&HTYJMR57?I:5O+4]A
MC_:X^*T<B,WBA9%4@E&TZUPWL<1 X^AK] +KQMX>L=WVG7M,M]IVMYMY&N#Z
M'+5^3U?5-M^P-K3'_2/%EA$,?\L[5WY].2.*>%KU_>LN;Y[&.>9;EB]FZDU1
MWVCOMV[?J?4=U\8O =CO$_C3P^C)]Y/[3A+#_@(;-9-U^T1\-K/=YGC+2VVC
M<?*E,G_H(.3[5\U^*/V-]#^'VAR:QXG^(Z6-E&,$+I?S.V.$3]]EC[ 5X%I/
M@VY\:>*AH_A*SOM5>5R(5D15D90?ON =J#&,Y8@>M>S2I8^NG*%-675O_@GS
M,<#DG_03)^D6OS1]2_&W]L^T@M7TGX?R_:;B1<2:U)$56+/:)& );_:88'8'
MJ/GWX<OX*U+Q!)K/Q&UR^N8VE,CV=O%)+-=/G):64]%/L2QYY7O]%^#?V$="
M31;=_%.M:C+JS'=+'I<D<<"=/D!>-F;O\W'T[UUEO^Q/\-X00ZZM/GO)> 8_
M[Y45K#&8^C%TZ<8KSUO]]QK^P*2LIU']W^2,NT_;0^&/AS3;>QTS2=8BLK<>
M7%;V=C$B(H] 9  /\:IW7[>GA-=WV;P[K4O/R^;Y*9'OASBNVM_V0?A7"27\
M.RSY[2:A<#'_ 'S(*UK7]F/X86A!3PA:-@;?WLLLG_H3GGWKAY<9+5R1G[;(
M([4JC^:_S/'KK]OS3DW_ &;P;=2\?+YM^J9^N(VQ^M95U^W]=L3]G\%0Q#''
MFZD7Y]>(AQ[5]%VOP)^'=GL\OP5HC;1@>;9))^>X'/XUK6OPS\'V.W[-X4T.
MWVG*^5IT*X/MA:7L\4]ZB^X7UW)(_#A&_63_ ,SY(N/V]?$[$>1X:TF,=_,>
M5_Y,*S_^&VOB3J2_Z+I&B#:?F-O93M^>937VY:^']+LABWTVS@&=W[J!%Y]>
M!UK0H^KUWO5_ /[6RR/P8%?.7_ /A1OVD_CEJ6Y;72YE(.X_9M$9R!Z<J>*/
M^%F?M)ZME8[+Q!'&XW#9X?2-<>S&'/ZU]UT4_JL^M5A_;F&C\&"I_-7_ $/A
M3=^TMK!_YF*/S!CI';XX_P" [?TH'PU_:4U;:TE[X@B1AL.[Q D0Q[J)@?TK
M[KHI?4T]YO[P_P!8YQ_AX>FO^W?^"?"B_LW?'/4MINM4G4J<#[1K;,0/7ACQ
M_A2?\,3_ !*U)2+K5]% 4Y N+V=OQ&(C7W911]1I=6W\P_UHQR^",5Z1_P""
M?$=O^P5XH8GS_$FD1C''EI*_\U%:MK^P#>-C[3XU@B&.?*TUGY].91Q[U]CT
M52P-#M^)E+B;,Y;5$ODO\CY.M?V ]/39]I\974O][RK!4S],R-C]:U;7]@OP
MFNW[3XBUF7GYO*\E,CVRC8KZ<HJU@Z"^R<\N(,SEO6?W+_(^>;;]AOX>P##W
MFO7'.<R7<0_#Y8A6K;_L:?#&'=OTV]GST\R^D&/^^2*]QHJUAJ*^RCFEG&82
MWKR^\\EM_P!E'X56I)3PI&Q(P?,O;E_YR&M6U_9W^&UGM\OP;I;;1M'FQ&3_
M -")R?>O1:*M4::VBON.>688R7Q5I/\ [>?^9R%K\'O =CL,'@OP^C)]U_[,
MA+#_ ($5S6K:^"?#UCM^S:#IEOM.Y?*LXUP?486MJBK4(K9'-+$5I?%-OYLB
MM[6&U4K!#'"I.2(U"@_E7A_[4'P'UWXV+X:_L.]TZT;3#<^:-0DD0,)/*QM*
M(W3RSUQUKW6BE4IQJ1<);&N%Q=7!UXXBD_>7ZJQ\)?\ #"/C[_H+^&__  )N
M/_C%>M?LU?LU>)O@WXXO]:UJ_P!)NK:?3GLTCL)97?<TL3Y.Z-1C$9[]Q7TG
M17+#!TJ<E*.Z/:Q/$6.Q5&5"HURRWT"BBBNX^9"BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH *H:IH.FZU'LU#3[6]7&,7$*
MOC\Q5^BIE%25I*Z \\U?X#^$-4R8[*;3W/\ %:3$?HV1^E<3J_[,;C+:7K:M
MZ1WD./\ QY3_ .RU[S17E5LIP5;XJ:7II^1FZ<7T/CCQ=I.N>";F3P_?ZB7C
M*+(]O;W+-"1G*Y7CGC/(]*RM$US5-%F<:7?SV$EP!&S0S&/<,\9.1CGOVKUG
MQ%\!/%OB+7;[4[C4=*>6YE:0YEEX&>!_J^@&!^%9O_#-7B?_ )_M)_[_ $O_
M ,;KX"IEN-55RI4Y)+;O8XW"5]$$/P(\:^()%EU2[AA/4M>732N/^^=W\ZZ/
M3?V8X%P=0UV1_5+: +C_ ($Q/\J]9\'Z?J.D^&=.LM6GBN;^WB\J26$DJP!(
M4Y(!)VXR<=<ULU]G0R3!<JG.#;?=_P"5CI5*.[/.=-^ /@_3\>;:7%^P_BN;
MAOY)M%=7IO@G0-'P;+1K&W8?QK N[_OK&:VZ*]>E@\-1_ATTODC51BMD%%%%
M=A04444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
M !1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
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MQ_JWQ*\2?"WXO:)H.D^/-*T^'6K2]\+2S/INJ6$CM&9(A-^\1HY!L8.<DG(
M'4 ^@:\J_:Q_Y-9^,G_8F:S_ .D,U>JUY5^UC_R:S\9/^Q,UG_TAFH ZKX3_
M /)+/!O_ &!K/_T0E=77*?"?_DEG@W_L#6?_ *(2NKH **** "BBB@ HHHH
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MM1_;YT6/=]@\)7]R>WVBZ2'/'L'[UWVG?L=?"^QQYVCW5^?6XOYA_P"@,O\
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M3=-M-'L(+&PMHK.S@0)%! @1$4=  .!5FL\1BY5O<BK170\Z=1RT6B"BBBN
MR"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BB
MB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *\J^/G_-.?\
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M#]C3Q/K0CTO1-0U/Q7!#<71,:1R:@\LEFI+'@R 87).2PQGK7T=::I:>)/\
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MJT4 >5?\))\;_P#HGGP__P#"\OO_ )34?\))\;_^B>?#_P#\+R^_^4U>JT4
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M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BB
MB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *\J^/G_-
M.?\ L<]-_P#:E>JUY5\?/^:<_P#8YZ;_ .U* /5:*** "BBB@ HHHH ****
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M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BB
MB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BB
MB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "O*OCY_S3G_ +'/
M3?\ VI7JM>5?'S_FG/\ V.>F_P#M2@#U6BBB@ HHHH *^?\ ]LGXB>)O!/@[
MPAIG@_Q;!X&UWQ+XDMM*_P"$AN;2"ZCT^U$<L]S.T<_[LJD<+$Y(P.XZCZ K
MYW_:RO/@K;ZU\-(OC;H0O]&GU69--U74W(T:PO!%N47H,JH1(H8+YB.GRMG:
M,D@%7X(ZUXD\'^!_&7C[Q7^T-I?QX\)V%A+<1S:)HFGV45HUNC238EM9&#L5
MP-K$8P/6O'?^%N?M$^!_ACX=_:'\4>,-%U#P)J4UG>ZI\.8-$CB.FZ5=2HJ2
MPWN?-DG1)(V*OA1N?D[0*QM(\(^"/''QT^-VC?L_QZ5_PA^I?"ZXTW65\*B/
M^QY=9E9UM!&(OW1D$1D!V8'+=RU4?'W[17@GXG?\$_\ PQ\-= UJSOOB3X@L
M=)\)Q^$8BIU*WODEABF$MMC?&B>5(=[*JG"X.6% 'Z,K(K1AP<J1D'VKX1F^
M*W[1'Q$^'?BGX^^"_&6BZ9X'TBXOKC2/A[<Z''-_:^FV<CI)+->9\V.9Q'*R
MK'\IVIR QK[8NO$&CZ/?Z3H5[J]C::OJ4<BV%C/<HD]WY2 R&*,G<^P$%MH.
M 037P'\-?VBO _P=_87\9?#CQ+KMEIWQ$\,PZSX;D\+3E4U"ZNI)IEM_)MR-
MTJ2>=&=ZJR@%LG@F@#WSXS?'WQ-XD\+_  ?T7X47=KH_BCXK%9[#5]2MUN4T
MJP6U%S<7'E9VR2*C(%4Y4L<'M4OP$\=?$GPC\;?$'P;^*GB6S\=:C'HL7B30
M_%5KID>G/>6IF,,\4\$9V*\<A7&S.5.2<G%>6^+H?^&=X_V-_$OC,_V7H/A7
M3Y/#6N7TT?[O3Y[K38HHVE;GRU\V$J6. ,\D#KVGPZ\>:%\;OV\-7\1^"M3M
M?$?ACPKX%71;S6M-=9[1[VYO5G6%)ERLA6.+)VD@$D<$&@#ZQKRK]K'_ )-9
M^,G_ &)FL_\ I#-7JM?-O[6VC?%!O@)\8[B/QAX17PS_ ,(OK#G3F\*737OV
M;[)*3']I_M()YA7(\SR< \["/EH ]G^$_P#R2SP;_P!@:S_]$)75UX+\,O#W
MQH?X;^$VM?'_ (#AMCI-H8HYO ][(ZIY*8#,-84,0,9(49]!TKI?^$<^-_\
MT4/X?_\ A!WW_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#
M^'__ (0=]_\ +F@#U6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A_
M_P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\
MA!WW_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=
M]_\ +F@#U6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_
M "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N
M: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#
MU6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5H
MKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J
M_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#U6BO*O\
MA'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5HKRK_ (1S
MXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J_P"$<^-_
M_10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#U6BO*O\ A'/C?_T4
M/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'
M_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J_P"$<^-__10_A_\
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M_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\
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M_P#10_A__P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\
MT4/X?_\ A!WW_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#
M^'__ (0=]_\ +F@#U6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A_
M_P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\
MA!WW_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=
M]_\ +F@#U6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_
M "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N
M: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#
MU6BO*O\ A'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5H
MKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J
M_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#U6BO*O\
MA'/C?_T4/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5HKRK_ (1S
MXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J_P"$<^-_
M_10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +F@#U6BO*O\ A'/C?_T4
M/X?_ /A!WW_RYH_X1SXW_P#10_A__P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'
M_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N: /5:*\J_P"$<^-__10_A_\
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M_P N: /5:*\J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\
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M_P#10_A__P"$'??_ "YH ]5HKRK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB
M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
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M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB
M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M\J^/G_-.?^QSTW_VI7JM>5?'S_FG/_8YZ;_[4H ]5HHHH **** "BBB@ HHH
MH **** "BBB@ KRK]K'_ )-9^,G_ &)FL_\ I#-7JM>5?M8_\FL_&3_L3-9_
M](9J .J^$_\ R2SP;_V!K/\ ]$)75URGPG_Y)9X-_P"P-9_^B$KJZ "BBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ***
M* "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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MUW#M0!N4444 %%%% !1110 4444 %%%% !1110 4444 %%%% !1110 4444
M%%%% !1110 4444 %%%% !116'XZ\8:?\._!/B'Q5JWFC2M#TZXU.[\A-\GD
MPQ-(^U<C)VJ<#N: -RBBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BL.\\8:?8^-M)\*R>;_:NI
MZ=>:G;X3,?DVLMK'+EL\'=>0X'<;O2MR@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBL/P=XPT_Q
MSI-QJ6F>;]F@U&^TQ_.3:WG6EW-:3<9Z>; ^#W&#WH W**** "BBB@ HHHH
M**** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ H
MHK#\8^,-/\#:3;ZEJ?F_9I]1L=,3R4W-YUW=PVD/&>GFSID]AD]J -RBBB@
MHHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "B
MBB@ HHHH **** "BL.S\8:??>-M6\*Q^;_:NF:=9ZG<93$?DW4MU'%AL\G=9
MS9'8;?6MR@ HHHH **** "BBB@ HHHH **** "BBB@ KRKX^?\TY_P"QSTW_
M -J5ZK7CG[1NL6^F7GPEMIMWF:CX[T^U@VC(WB&XE.?0;8G_ !Q0!['1110
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MU:[LOCO\7+:YU:Z6]OI$U73\W$PAB@#M_H/4101)]$%?2%% 'S__ ,,H:O\
M]'!?&#_P:Z=_\@T?\,H:O_T<%\8/_!KIW_R#7T!10!\__P##*&K_ /1P7Q@_
M\&NG?_(-'_#*&K_]'!?&#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R
M#1_PRAJ__1P7Q@_\&NG?_(-?0%% 'S__ ,,H:O\ ]'!?&#_P:Z=_\@T?\,H:
MO_T<%\8/_!KIW_R#7T!10!\__P##*&K_ /1P7Q@_\&NG?_(-'_#*&K_]'!?&
M#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R#1_PRAJ__1P7Q@_\&NG?
M_(-?0%% 'S__ ,,H:O\ ]'!?&#_P:Z=_\@T?\,H:O_T<%\8/_!KIW_R#7T!1
M0!\__P##*&K_ /1P7Q@_\&NG?_(-'_#*&K_]'!?&#_P:Z=_\@U] 44 ?/_\
MPRAJ_P#T<%\8/_!KIW_R#1_PRAJ__1P7Q@_\&NG?_(-?0%% 'S__ ,,H:O\
M]'!?&#_P:Z=_\@T?\,H:O_T<%\8/_!KIW_R#7T!10!\__P##*&K_ /1P7Q@_
M\&NG?_(-'_#*&K_]'!?&#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R
M#1_PRAJ__1P7Q@_\&NG?_(-?0%% 'S__ ,,H:O\ ]'!?&#_P:Z=_\@T?\,H:
MO_T<%\8/_!KIW_R#7T!10!\__P##*&K_ /1P7Q@_\&NG?_(-'_#*&K_]'!?&
M#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R#6?XA_8QF\6>']3T35_C
MO\7+_2=2M9;*\M)M5T\I-#(A21&_T'HRL0?K7TA10!\__P##*&K_ /1P7Q@_
M\&NG?_(-'_#*&K_]'!?&#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R
M#1_PRAJ__1P7Q@_\&NG?_(-?0%% 'S__ ,,H:O\ ]'!?&#_P:Z=_\@T?\,H:
MO_T<%\8/_!KIW_R#7T!10!\__P##*&K_ /1P7Q@_\&NG?_(-'_#*&K_]'!?&
M#_P:Z=_\@U] 44 ?/_\ PRAJ_P#T<%\8/_!KIW_R#1_PRAJ__1P7Q@_\&NG?
M_(-?0%% 'S__ ,,H:O\ ]'!?&#_P:Z=_\@T?\,H:O_T<%\8/_!KIW_R#7T!1
M0!\__P##*&K_ /1P7Q@_\&NG?_(-'_#*&K_]'!?&#_P:Z=_\@U] 44 ?/_\
MPRAJ_P#T<%\8/_!KIW_R#1_PRAJ__1P7Q@_\&NG?_(-?0%% 'S__ ,,H:O\
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M5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\
MHX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+X
MP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\
M@UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[
M_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0
M:^@** /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@*
M* /G_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G
M_P#X90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X
M90U?_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?
M_HX+XP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+
MXP?^#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^
M#73O_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O
M_D&C_AE#5_\ HX+XP?\ @UT[_P"0:^@** /G_P#X90U?_HX+XP?^#73O_D&L
M_0_V,9O#5E)::7\=_BY96TEU<7KQQ:KI^#-/,\\S_P#'CU>661S[L:^D** /
MG_\ X90U?_HX+XP?^#73O_D&C_AE#5_^C@OC!_X-=._^0:^@** /G_\ X90U
M?_HX+XP?^#73O_D&C_AE#5_^C@OC!_X-=._^0:^@** /G_\ X90U?_HX+XP?
M^#73O_D&C_AE#5_^C@OC!_X-=._^0:^@** /G_\ X90U?_HX+XP?^#73O_D&
MC_AE#5_^C@OC!_X-=._^0:^@** /G_\ X90U?_HX+XP?^#73O_D&C_AE#5_^
MC@OC!_X-=._^0:^@** /G_\ X90U?_HX+XP?^#73O_D&C_AE#5_^C@OC!_X-
M=._^0:^@** /G_\ X90U?_HX+XP?^#73O_D&C_AE#5_^C@OC!_X-=._^0:^@
M** /G_\ X90U?_HX+XP?^#73O_D&C_AE#5_^C@OC!_X-=._^0:^@** /G_\
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MOH"B@#Y__P"&4-7_ .C@OC!_X-=._P#D&C_AE#5_^C@OC!_X-=._^0:^@**
M/G__ (90U?\ Z."^,'_@UT[_ .0:/^&4-7_Z."^,'_@UT[_Y!KZ HH ^?_\
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MK'BKX>P>"_AB?B9X,T^Z;5]8TM/$-II/VB[A939I(\Y):)'S*4"D,R)D@#!
M+'[&7QL\>?&B^^*\_CJS.BRZ7XACM].T)XHUDTRT>UBECAD91EI,."Y8DARP
M&  !]+5\2_L+^./B#XA^.GQYA\3_  S_ .$2M;S71>ZA<_V_;WO]GWPMK9%L
MML:@R[H\R><ORC&W&:^VJ "BBB@ HHHH **** "BBB@ HHHH **** "BBB@
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MC\(Q%3J5O?)+#%,);;&^-$\J0[V55.%P<L*^]O'D9A^&_B*,G)32;A<_2%J
M/"?#W[2.N^&_V#_#_P 6]:B7Q+XMNM"M9DAV)"M[?W#K%"I5 JJIED3.T# S
MBN0^%GBSXYZ9\6]%L[OXO^"?C1!-<^1XO\&Z+#865WX41@?WT3),))4CDVHP
ME!<CHI8[EX'QIX.U#QK_ ,$A_"MMIUO=74MEH.DZG+%8C-P8()XI9FC_ -I8
MU=A_NU1\26_[/=]XM_9W_P"&=QX:B\=KXHL)$_X1/9]O72!&YOA?[,MCR>&\
M_P"?)(_O4 ?HM1110 4444 %%%% !1110 4444 %%%% !1110 4444 %%%%
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M*X?XT>*/ OPS\=?LP_$/1+_2D^$.AW.I>'O[8TF5+C3K&.YM5AMV,R%E6,/
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M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB
M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
M"BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH *
M*** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HH
MHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB
M@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH **** "BBB@ HHHH ****
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MHW@G27U/7=1ATRP5E0S3' +'H !R3[#T/I32<G9 <%_PCGQO_P"BA_#_ /\
M"#OO_ES1_P (Y\;_ /HH?P__ /"#OO\ Y<UZ?:7D&H6L-S;31W%M,@DCFB8,
MCJ1D,".H([U-2 \J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=
M]_\ +FO5:\\^&OQ<_P"%A^-_B3X>_LK^S_\ A#=7ATK[3]I\S[9OM8KCS-NP
M>7CS=NW+?=SGG  ,W_A'/C?_ -%#^'__ (0=]_\ +FC_ (1SXW_]%#^'_P#X
M0=]_\N:[37-:U^Q\5^'+#3O#?]J:+?-<#5-7^W1P_P!F!(]T1\EANF\Q_D^7
M&WJ>*Z&@#RK_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\ A!WW_P N
M:]5HH \J_P"$<^-__10_A_\ ^$'??_+FC_A'/C?_ -%#^'__ (0=]_\ +FO5
M:Y+XN>/O^%5_"WQ;XR^P_P!J?V!I=SJ?V+SO)\_RHV?9OVMMSMQG:<9Z&@#E
M_P#A'/C?_P!%#^'_ /X0=]_\N:/^$<^-_P#T4/X?_P#A!WW_ ,N:[CP'XH_X
M3?P-X=\1_9OL7]KZ=;:A]F\SS/*\V)9-F[ W8W8S@9QT%?,&D?M=_&_QM=Z[
M/X(_9G_X2GP]INL7VD1:M_PGMC9_:&MIWA=O)EB#KDH>#GV)ZT >S_\ ".?&
M_P#Z*'\/_P#P@[[_ .7-'_".?&__ **'\/\ _P (.^_^7-<5H_[8EIKG@/PI
MKT?A#4-/U/4O&D'@C5=#U2<07&D7CN5D+$*PD"_*PQMW!ARIR*^BJ /*O^$<
M^-__ $4/X?\ _A!WW_RYH_X1SXW_ /10_A__ .$'??\ RYKU6B@#RK_A'/C?
M_P!%#^'_ /X0=]_\N:/^$<^-_P#T4/X?_P#A!WW_ ,N:]5HH \J_X1SXW_\
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MOVA;C[),R@O%YJ_*^UB5W#@XR*TJ /*O^$<^-_\ T4/X?_\ A!WW_P N:/\
MA'/C?_T4/X?_ /A!WW_RYKU1CA2:\^^ ?Q9_X7A\*](\9_V5_8O]H27*?8?M
M'VCR_*N)(<[]BYSY>[[HQG'.,T 9G_".?&__ **'\/\ _P (.^_^7-'_  CG
MQO\ ^BA_#_\ \(.^_P#ES7JM>=^,OBY_PB?QD^'7@/\ LG[5_P )?#J<O]H?
M:=GV3[)%')CR]AW[_,Q]Y=N.^: ,[_A'/C?_ -%#^'__ (0=]_\ +FC_ (1S
MXW_]%#^'_P#X0=]_\N:]5HH \J_X1SXW_P#10_A__P"$'??_ "YH_P"$<^-_
M_10_A_\ ^$'??_+FO5:* /*O^$<^-_\ T4/X?_\ A!WW_P N:/\ A'/C?_T4
M/X?_ /A!WW_RYKU6B@#RK_A'/C?_ -%#^'__ (0=]_\ +FC_ (1SXW_]%#^'
M_P#X0=]_\N:]5HH \J_X1SXW_P#10_A__P"$'??_ "YH_P"$<^-__10_A_\
M^$'??_+FO5:X[QA\4M)\%^-O _A>]BNI-2\77=S:6#0HIC1H+9[AVD)(P-J8
M& 3DCMS0!S?_  CGQO\ ^BA_#_\ \(.^_P#ES1_PCGQO_P"BA_#_ /\ "#OO
M_ES7JM% 'E7_  CGQO\ ^BA_#_\ \(.^_P#ES1_PCGQO_P"BA_#_ /\ "#OO
M_ES5JT^,OVK]HS4/A7_8^W[)X9B\1?VM]ISNWW+0>3Y6SC&W=NW]\;>]>ET
M>5?\(Y\;_P#HH?P__P#"#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JT4 >5?\
M(Y\;_P#HH?P__P#"#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JT4 >5?\(Y\;
M_P#HH?P__P#"#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JT4 >5?\(Y\;_P#H
MH?P__P#"#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JT4 >5?\(Y\;_P#HH?P_
M_P#"#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JT4 >5?\(Y\;_P#HH?P__P#"
M#OO_ )<T?\(Y\;_^BA_#_P#\(.^_^7->JUY'-^UC\*8)GC;Q6I9&*DI873+D
M'L1%@CW'%1*I"'Q.QTT<-7Q-_84W*V]DW^1/_P (Y\;_ /HH?P__ /"#OO\
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M\O?M;;NVXS@XSG!H Y'_ (1SXW_]%#^'_P#X0=]_\N:/^$<^-_\ T4/X?_\
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M %%%% 'E7[2W_).M(_['/PG_ .I#IU>JUY5^TM_R3K2/^QS\)_\ J0Z=7JM
M!1110 4444 %%%% !1110 5\B_%KXC?'O3OB#K-IX?TK58-%@G9+1M/T1;J.
M2+^%_,,3Y)')&>"2,<5]=45TT*RHR;<5+U+C+E>JN?"O_"TOVD_^?+Q'_P"$
MPG_R/7F_Q<\2?$GQ%-I\GQ!35H=@9;1-0L/L:'IN*H$12>1DXST]J_3*L+QE
MX'T+XA:*VE>(-.CU*Q+B01R$J58=&5E(93[@]"1T->C3S"$)I^R2]-S:-9)_
M"?!7PW\<?&S0?"L%MX/@UZ?0=[-"UOH_VR('/S!':)L#(/ .,YXSFNH_X6E^
MTG_SY>(__"83_P"1Z^XM/T^VTJQ@L[.".UM+=!'%#"H5$4# 4 = !5BIECX2
MDW[*(G55_A1\O_ 'Q]\:M<^(%M8^,M+U$Z!)%(9[C4=(%F(2$)0JPC3)+!1C
MGAB>U;/[-?\ R6[]I+_L;;3_ --5I7T/7SU\2?V /@+\7O&^J^+_ !;X#_M;
MQ%JCK)=WG]L7\/FLJ*@.R.=4'RJHX Z5YU:JJLN914?0RE+F=[6*_P ?YIK?
M]IS]GN6WC\Z>-O$+1Q_WF&G9 _$U\>:Y\!_AE\2OV'_%'QY\5^)M0N?BU?:9
M>7=]XEDUN6)X+[+K_9?D;_+$><0>5LW%3A<97'WYX!_9?^&?POM?"=MX8\-?
MV9#X5FO+C1E^WW4WV62Z7;<']Y*V_<#T?<!VQ7Q'\1OV0?'7Q.\7>)8-1_9D
M\"6GB_6GGMY/BC9^*9(M)42Y!O%TC>S^=L8G)!/F?-DU@0=#\<O",7QX\2_#
MOX?67@ZY^(UYI/@.RU2[T;6O%K:)H-BLN$BNFB@47%S/^[=20X1$V\;GR/-O
M 6CZAXP_9;\-^"K_ %XVUI8_'&WT&SNO#.J3316-JK !+&Z=C)Y:[G\MR20"
M#7W5\1/V,?A#\8M/\+P>//",'B:[\/6,6GVE_)<3VTYB10 KM Z%USD[6RH+
M-@<FM;PW^RK\*O!^DPZ7HGA"WTK3(=>A\3Q6=I<SQPQZC$BI'.J"3"X55^0#
M8<9*DT >*?!WX0:#^S7^V%K_ (2^'L=]IOA76O W]NSZ)-?W%W%_:$=[Y7G@
MRR,VYD.#S_A7S[=?!+X>>.OV*?%_QX\5^+-3B^+E_I>I/J/B636IHY(KLM(G
M]E&VW^6(VPL'D%-V&P,<8_21OA_H#?$!?&QL/^*G733HXOO.D_X]#*)3'LW;
M/O@'=MW=LXXKRKQ'^PS\"?%GC75O%NI_#G39M?U6&>&\NHIIX5E\Y665_+21
M465@[?O0H?)SNSS0!W?P%_Y(;\.O^Q<T[_TECKXZ_9Y7]IUO#WC,?#!OA,OA
M$^-/$ @;Q9_:?]H"3^T)O,+>1^[QNSMQVQFOO'0=#LO#&AZ=H^F0?9M-T^VC
MM+6'>S^7%&H1%W,23A0!DDGUK,\#_#_0/AOI5UIOARP_LZRNKZYU*:+SI)=U
MQ<2M+,^79B-SLQP#@9P !Q0!\9?&;X!ZQX$^#?@+0]:\7377C3Q;\5].U77/
M$FD0BU9;NX9U9K9>=@CC5$1NOR!L#. V'P1X1_8U^-OQ+L/"]YK_ (=\!W/P
MQN?$NHV=C?R75Q'>PW)C:[@-PSCSRAX+Y7<!GCBOM#QE\/\ 0/B FC+KUA]O
M71]2@UBQ'G21^5=PDF*3Y&&[!)^5LJ>X-5-8^%/A/Q#XJNO$>IZ+#J&K76C2
M>'[B2Y9WBFL)'WO \)/ELK-U)7..,XXH _+_ ,._#'6OA'\5/@'XYM/"&E_#
M^[\4>)=/M)M2E\=W6N>(-=MYQF5YU!6V:-U*F1D3 9DQ@&OJC0?@=X5^+/[<
MGQ9UGQ7:SZM_PBK^'=0TBR-U+%;P7GV9R+ED1@)'41J '!4 MQS7>>%O^"?/
M[/O@K58-3T7X<6EEJ5O?0:E;W?V^\>6"XAD$D;1LTQ* , 2JX4XP01Q7L^C?
M#_0/#_B_Q#XHL+#R-=\0+;KJ=UYTC>>($*0_(6*KM5B/E SGG- 'YIGX(Z1_
MPQA>?&R+4]:@^)GAW6;Y_#VL1:C*J:0B:W)%Y4, 81%&R[-O4EBYR<8%>[R?
M WPQ^S?^U?\ "/7?#-_KD>H>++;6HO%5_J&J37CZQY-F)UFG#DC>'&X; JCL
MM?2G_"@/ 7_"J[KX<?V#_P 49=2R32Z9]LN/F>2X-RY\WS/,&9B6X;O@<<5O
MZU\/?#_B+Q1X;\1ZCI_VC6?#IN#I=SYTB_9_/C\N7Y0P5]R<?,#CJ,&@#\B_
MB5X2OY/AO;?'_0?#4>C2W6KQ7>E_$/Q7X\GN_$VHK)>!4$5K;[+6-MA8&$J=
MD:L#DJ37VU\:OASX<_:._:VTSX;?$FXN[WP7I_@U==L/#4>H2VD&HWSW3Q2S
M/Y3([F)%3"[OEWD]"<]=<?\ !.G]G*ZU35]0D^%NF_:=4#BXVW5TL:[CDF&,
M2A8#GH8@A'08KT+XR_LT_#3]H+1=-TOX@^%+?Q';::VZS>2::&>#( (6:)UD
M .%R-V&V@D' H ^5_P!IYH_A5^R_X1\!_"_Q-J/CC0+KQG'X=OO^*K@@NE@+
M33/IAU,_+; ,J0CS,L$(0YS7EGA7P3XN^#>O:WH>D_!8_!+PQX@\'Z\FIZ%+
M\2;77EU)DLG>*YAM'D\[S$951GB##;)R .:_0FW^ /PZM?A2OPSC\'Z7_P (
M((O)_L-H=T!&[=N.>2^[YMY.[=\V<\USGP:_9 ^#W[/][?7O@/P-9:+?7T1@
MGNY9I[R9HCC=&'G=V5#@952 <#(H ^?_ !5XLT:[_9S_ &/H(=4M99]0\1>%
MC:PK*"\WE0@2E5ZG8<!O[I(!P2!7/ZW\#_ VF_M(?M7>);?1A'X@T_P;'?VE
MS]KG)2:^LKT7;["^T[]J<$$+_"%S7T;X2_8=^!G@35AJ>@?#RPTO4%U.'6$N
M(;BXWQW,3%XRA,GR1ACGREQ&<#*G QU/B[]FWX;^._B"/'&M^&8[KQ5_9<VB
MMJ,=W/"SV<L;QR1,L<BJV4E<!F!89X(P, 'R1X;^&_AS]HSQE\'_ (:?$BXN
M[WP5I_PGTS7-/\-1ZA+:0:C>L1%),_E,CR&)%3"[OEWD]"<]5\<-+\'^"_V<
M/"_PN\(>(O$?Q&MM2\6+X>L--LO%]O;M<2!I9I-,O-0V,T=O&@*&,?OB%CC#
M<YKWWXC?LF_";XM^"?#OA/Q;X-M=8T3P["EOI4;W$\<UI$J*@1)TD67:55<@
MN=VT$Y(%3ZS^RS\*/$'PAM/A??>"--D\"6;*]OI,>^,0R D^:LB,)!(=S9D#
M;FWMDG<<@'R-^Q'X*U/X+?M>^,? 8T?0?!>E3^$$U6;PIX;\07>K06UQ]J5$
M>X>Y8E;C83PN!L*''-<?/\,=9^+'[*GP1TC2!H?BR.WU#7;JZ^&FK>(9-'D\
M2(+R8*T,D<B,SP$[N2%'F9/H?M[X2_LB_"+X%ZY!K/@3P7;>'=5BLI=/^UP7
M5P[R02.KNLA>1O,.Y$(9\D8P"!Q1XF_9%^$7C+X9Z;\/];\%VNH^%--GDN;*
MSFN;CS+:221I)&CG$GG+N9VSA^0<= !0!Y'^P'JNG>'O^$\^'"^$?$GPZUK0
M;BVO;CP=K&O)K5EID4Z,$%C<CY_+?RF=D<G#,<$Y-=E\9O\ D\7]G?\ Z\_$
MW_I);UZ7\'/@)\/_ -G_ ,/S:+\/_"]GX;L)W$D_D%Y)9V&<&261FD?&3C<Q
MQDXQ6YK7P]\/^(/&/AWQ5J%A]HU[P\EU'IEWYTB_9UN$5)AL#!6W*BCY@<8X
MQ0!^9>F?L[>'-'_8CMOC?:WVMQ_$W1-4EO=*UD:M<A;",:PT9MH81((TB92Y
M.%R6D8YYQ7TU\:_ASX<_:0_:VTSX;?$F>ZO?!=AX-77;#PU'J$MI!J-Z]T\4
MDS^4RO(8D5,+N^7>3T)S[Y_PH+P'_P *GD^&G]A?\43(6+:7]LN.=T_GG][Y
MGF?ZT[OO>W3BJOQJ_9N^&O[1&E6&G_$/PI:^(X-/<R6CO++!- 2 &"2Q.D@4
MX&5#8.T9!P* /ESX@>!/!5YJ_P $?@;#\0]4UKX1WFJ:U;ZBQ\0>;)=75NJ/
M!HTUU"58(AF<")COQ&BYRH-4=1^'_AS]G7XD_%'X9?#.[NH/!6H?"[5-9U3P
MQ)?RWD.DWD?R0S(TKNT9F263*%OFVAN@&/J?5_V6?A/KOPEL_AE>^!=+E\#V
M7S6VE*C(('YS*DBL)%E.YLR!MYW-DG)J/X:_LI_"?X/^$==\,^#_  99Z+I.
MNP/;:F(YII)[N)E92CW#NTI4!VP-_P NXXQ0!\6^-/@7X-^&O['OPK\1VNH7
MN@:]XOUSPA=>(?&$E^[7*D$$3JTK,D(A61M@50JA5R#BO4+7X.^#_P!EC]J3
MX3V?PGNK^TN/&::E'XB\/2:O/>IJ4$=J\R:A()7?:ZS*HW\ [R!C)SZW^T9\
M"Y/%GPN^'/@OPMX?AU+0]"\4:%+/IEQ,C1QZ7;3*)0WGM^\58A@J2S,.S$UU
M'P<_93^$W[/^KZIJO@#P58^'M3U(%;B\1Y9Y=A8,8T:5V,<9(!V)M7*KQP,
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M#!@;1[5KVY62S,*;(]LRR"4X7CESG SG% 'Y[^(/"OBOX^_%CXKZ_K?P*O\
MXO7VA^);W3M/UF/XGQ:!_P (]! VR%8;,L#"0$67S'!#D[@,9SZIYFK_ !V\
M*?LR> /B[K<B>&O$EOJO]N+I^NPS1:[<6F$LX);^TD*2[UW.RHX+NIZ,,#Z9
M^*G[$_P2^-GC!/%/C+P!8ZOKZ[=]\EQ<6S3[0 OG"&1!-@*H_>!N!CIQ77>.
MOV?_ (<_$KX=6O@/Q'X/TS4/"-HB)::6L7DQV@12J& QE6B(4E04*D D9YH
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M>*X_V%_A+\*_#/AJYU[Q1\1[RZGA\-+=I83-H(N9KV:/SW(2(-;M#%N;M,<
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MW2_V?_#7[-?[6GP<N_!%SK-O-XQMM7M/$SZAJUS>-K#PVBS1W$YE=LR!]QX
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M"/Q \:V%K%H_A^ZN)8X]SI:P6B3L 3DD90G&3^M=)_PFGQ>_Y]]6_P#!,O\
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M?P*O_B]?:'XEO=.T_68_B?%H'_"/00-LA6&S+ PD!%E\QP0Y.X#&<_<G@O\
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M >5?\+D\7?\ 1"?B!_X'>'O_ ):T?\+D\7?]$)^('_@=X>_^6M>JT4 >5?\
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M'>'O_EK7JM% 'E7_  N3Q=_T0GX@?^!WA[_Y:T?\+D\7?]$)^('_ ('>'O\
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MA[_Y:T?\+D\7?]$)^('_ ('>'O\ Y:UZK10!Y5_PN3Q=_P!$)^('_@=X>_\
MEK1_PN3Q=_T0GX@?^!WA[_Y:UZK10!Y5_P +D\7?]$)^('_@=X>_^6M'_"Y/
M%W_1"?B!_P"!WA[_ .6M>JT4 >5?\+D\7?\ 1"?B!_X'>'O_ ):T?\+D\7?]
M$)^('_@=X>_^6M>JT4 >5?\ "Y/%W_1"?B!_X'>'O_EK1_PN3Q=_T0GX@?\
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MD\7?]$)^('_@=X>_^6M'_"Y/%W_1"?B!_P"!WA[_ .6M>JT4 >5?\+D\7?\
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MK7JM% 'E7_"Y/%W_ $0GX@?^!WA[_P"6M'_"Y/%W_1"?B!_X'>'O_EK7JM%
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*BBB@ HHHH __V0$!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>15
<FILENAME>lgnd-20181231_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8"?>
<xbrl
  xmlns="http://www.xbrl.org/2003/instance"
  xmlns:country="http://xbrl.sec.gov/country/2017-01-31"
  xmlns:dei="http://xbrl.sec.gov/dei/2018-01-31"
  xmlns:invest="http://xbrl.sec.gov/invest/2013-01-31"
  xmlns:iso4217="http://www.xbrl.org/2003/iso4217"
  xmlns:lgnd="http://www.ligand.com/20181231"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:srt="http://fasb.org/srt/2018-01-31"
  xmlns:stpr="http://xbrl.sec.gov/stpr/2018-01-31"
  xmlns:us-gaap="http://fasb.org/us-gaap/2018-01-31"
  xmlns:xbrldi="http://xbrl.org/2006/xbrldi"
  xmlns:xlink="http://www.w3.org/1999/xlink"
  xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
    <link:schemaRef xlink:href="lgnd-20181231.xsd" xlink:type="simple"/>
    <context id="id13a97144b904710b9835494780d5820_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="id52ed0969c704d12ac017e1b160c1fed_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ic47989b86a534d43a5bfc32cf62712d3_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i60f3b04793a34fca8e8b2fc0fd8651db_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i1c77c0695f9f4bc39202a1ee3b68fe5b_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i15a3fcbde8c3460cb635412e65ed0c9c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i9ae47d774632454eacbfe62e6c31f927_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8689e4eec8504099bab348e57f6a9828_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i8a17769dfb7942a285a0d743e736cb10_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ib8aea3ed0ca949ac8970d2f8fe87f5bf_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i57170c9749ff46cb9f3837ec92589b71_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ia775da1fbd8a416c8effcacdb92628e3_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i47f87ffe68104f86a60d18b2b37e6cf3_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i18a21a167bc74581b1487f6c8625553e_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i719ef5c241d44dbd96e30c1fa3f49f12_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i1d061d85ca7a40dba5a324fbc7d0020f_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i815a29c81959435e8d5fef20b9d28e7a_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i26c94f297be24d6a90b411c3a92ab896_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i07237780f1df476eab12d1e41646c600_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyPromactaMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia7034272bd6c43f6b5e9790c96dd349d_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyKyprolisMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ifeacc0dfa0ef409c9bf44db88ebbe700_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyEvomelaMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i305991a6fef5462c822324d86c4372dd_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:RoyaltyOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i1d2a7464c56c40d39f92de328c3dd17e_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i2534882e69ce43a6b613a1d083bfb3bd_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i4f60f855c1a14d8ab2bd47c786fc554e_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ie60c64b8008d42408987815303a30765_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia6e4af4ff3e0471097da34093a9ca62b_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="icd3fbafcbe94483b8d0196d9163c3fdb_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestoneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i0313533c50f047899180474a41ba7930_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i39dc95b331cd4a8faf8361f5540b8486_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ic8aa5f1c584f420aa7237defcce7252f_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesAndOtherProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i6a68a109b1a44264b74ff24de2d81961_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i4a0ce876e13c454b96f993d4d4ad5af9_D20070101-20071231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2007-01-01</startDate>
            <endDate>2007-12-31</endDate>
        </period>
    </context>
    <context id="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i6b500c2fbd5346e2a6d6116c3b290d3c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8e9409e1ae334493b8b799a5136ed402_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:SeniorNotesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i970ccee7a80949d687b85a9d2bf7e349_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="id59bcc52dcb84716a983b5657976b3d8_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-22</startDate>
            <endDate>2018-05-22</endDate>
        </period>
    </context>
    <context id="i07c0e2d53ab44177baafdb7c634d98df_D20180619-20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-06-19</startDate>
            <endDate>2018-06-19</endDate>
        </period>
    </context>
    <context id="ie0bd90f3b36c43ff967e6b073bb482f5_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="ie646486a057a4a24abd210fcf89ec5ac_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="i5528cc9246cd4cbf9e55a7081d960d09_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i36c8e54238ca4f048bcdea0102a51a07_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MaterialSalesCaptisolMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ie6b95d8edafe43388cdc0a5d870ca950_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="icf8c60c7fdb64e0ba05e9b87d3d24fd7_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="i68d6900fd0a8486397608f93ae2f2950_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i1ab3629dd4a84f25af6a6ed28fff01a6_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="ibd4aa0b2117641deace84f081e7d99ce_I20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2014-08-31</instant>
        </period>
    </context>
    <context id="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i788db1d002a24118902ba114a1c848a8_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i94bfc7a6eb3c4e7f8de61d82318efc87_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i4f4b2d2a5e634e08a972694ba181cfbf_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputRiskFreeInterestRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="if82e065acc144b048906db168419d424_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ibf06eb88f9114519b8566ae3991390c1_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputExpectedDividendRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i05c9c59e0a404b2384aa8481bfe4e0f8_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="idc51ddeb3e934105a34f1deb7f263b29_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputCouponRateMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="iab43107ea2de411d8ec195b05082d875_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i7f9f95d1537a49879879507d3c5b2ba7_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">lgnd:MeasurementInputRemainingTermMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="if6d885e1e1c9488c9c8b980b72ab5539_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AociIncludingPortionAttributableToNoncontrollingInterestMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201615Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201615Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:VestingAxis">lgnd:VestingPeriodOneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:VestingAxis">lgnd:VestingPeriodTwoMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i2ba96270f73845a489eec892606f151e_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:SeniorNotesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i0aadecee51e54de98ac550079bea27c4_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i064e8a313dcd4597a31a3e322d0fb198_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="ia1016c7a3fb3456dadccac23f7e35a59_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="i5be21f383f784dc5bdb8f26fd11bd5f8_I20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-06-19</instant>
        </period>
    </context>
    <context id="id3f44e4150824aac8cb8233b4f6c5332_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i4a4309c3a4644756b0b0e2a41966e07d_I20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-05-22</instant>
        </period>
    </context>
    <context id="i827aa32e6966431f90040e4f23139fce_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:LicenseFeesMilestonesandProductOtherMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i019545928c8d42fa914265e7cce06db4_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i421c6d753d8042d6ba4f5dea715b2015_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i4f2d6682161c4d8580620d72aac72bec_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:OwnershipAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia92a709872af454ba4a10e9e097a3942_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1495b46d310b40f39b5ba48f1a435973_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="ia6fd586e979f42b98e809e8789d74966_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i752433d6202a4b8d86205c212edea90e_D20180101-20180331">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-03-31</endDate>
        </period>
    </context>
    <context id="iaffe39f2d0954dbd80e0485f4618b93a_D20140501-20140531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DerivativeInstrumentRiskAxis">us-gaap:DebtMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:VariableInterestEntitiesByClassificationOfEntityAxis">us-gaap:VariableInterestEntityPrimaryBeneficiaryMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2014-05-01</startDate>
            <endDate>2014-05-31</endDate>
        </period>
    </context>
    <context id="i383f1359ee76425995b33bc12c23ab90_I20160131">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-01-31</instant>
        </period>
    </context>
    <context id="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-04-13</startDate>
            <endDate>2016-04-13</endDate>
        </period>
    </context>
    <context id="i8c3752abd1af4925883b62910e38900f_I20170715">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-07-15</instant>
        </period>
    </context>
    <context id="i77dbc1a726434cedaf60137ef4ee8652_D20180523-20180523">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-05-23</startDate>
            <endDate>2018-05-23</endDate>
        </period>
    </context>
    <context id="if138f3f9b2b74770a5cce6db84ab24b9_I20160430">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:RelatedPartyTransactionsByRelatedPartyAxis">us-gaap:EquityMethodInvesteeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-04-30</instant>
        </period>
    </context>
    <context id="ia743eb727a504f64a2e98f6fafd87f67_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i487a7d2c1cd749679482b85797456924_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i07d723f5c7634c8f84df7f866754f3e9_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FinancialInstrumentAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i38901eeb0e374312bb0a645919532284_D20181001-20181031">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-10-01</startDate>
            <endDate>2018-10-31</endDate>
        </period>
    </context>
    <context id="ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-10-31</instant>
        </period>
    </context>
    <context id="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="iaa145923f25048de937e04721b4c84da_D20181001-20181031">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:VernalisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-10-01</startDate>
            <endDate>2018-10-31</endDate>
        </period>
    </context>
    <context id="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-10-06</startDate>
            <endDate>2017-10-06</endDate>
        </period>
    </context>
    <context id="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-10-06</startDate>
            <endDate>2017-10-06</endDate>
        </period>
    </context>
    <context id="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-10-06</startDate>
            <endDate>2017-10-06</endDate>
        </period>
    </context>
    <context id="i57c56b2221e94885a3513e61361de5d2_I20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="lgnd:VariableRateComponentAxis">lgnd:ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-10-06</instant>
        </period>
    </context>
    <context id="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i0a8ca3d45f2d43049621874687484bb9_I20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-10-06</instant>
        </period>
    </context>
    <context id="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ida162efcc0e64c3698e0382c9a821d87_D20171006-20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-10-06</startDate>
            <endDate>2017-10-06</endDate>
        </period>
    </context>
    <context id="if12b4d59cd2641ccb993432a96845435_I20151231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2015-12-31</instant>
        </period>
    </context>
    <context id="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-08</startDate>
            <endDate>2016-01-08</endDate>
        </period>
    </context>
    <context id="iccecb2c1cc3b4381917487ee6b36dd68_I20160108">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-01-08</instant>
        </period>
    </context>
    <context id="i1523a02160ea4340b895af4cbcc28c78_I20160108">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-01-08</instant>
        </period>
    </context>
    <context id="i17a78122d7374267a4ec43cb6b8f9235_D20160108-20160108">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:OMTInc.Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:DevelopedTechnologyRightsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-08</startDate>
            <endDate>2016-01-08</endDate>
        </period>
    </context>
    <context id="i2233588cfcdd4d1d8216daf3329f3545_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i22719832b06742dcae5a658d47223931_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i754ca8ba8ad24cac9f16597b92a3ea5f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib03a2af9f5d54545a7ec5a4137113457_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i1908cb4c829d42b2844e3bb3f6368f63_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ia9cbdd5a3f014dbfba8949b4362c8099_I20151231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2015-12-31</instant>
        </period>
    </context>
    <context id="i64f8a58aefc1411cafeabef5c6a7b1fd_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ie8c9c9e6cb294fdbb37cef5bce12b5c7_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i36f2d5d73c464b0db83cc19d3975cda9_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ie7d6396714744e2880bfbeacc09c78a1_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib357eeae00de4b2f9b1a22317457315f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i8dcdef9f22634f7090bf5d69fcdb1a55_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i337533b66aed409fbb551874229f75dc_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ibd9630ec50374d25a30576be33a7d809_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ied16ee55eeae4367832c19a676fd4c62_I20151231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2015-12-31</instant>
        </period>
    </context>
    <context id="iac4562685c694e1aa2783376bb16c397_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="id099ffb3f70c4870880029056f3695be_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i8eaac6d98c2544b09548e8e62b89c4c3_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ic130ac71bf1e42c7b737b642085cce55_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ia4692046f93b4663b7e83e2a8a873af5_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ibcf1b8f7afc644a7b9ad7768719336a8_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i57f18aa010824bad8480819ba46172f0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="if47ef23bd3e44c4993c4afa7d1be94c7_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ifcedb617c87e4dcb92d2c7b639fcd223_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i0b5020617b024955ba56ec0766513aad_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i4649e39780384e179cb5b74b4192a407_I20151231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2015-12-31</instant>
        </period>
    </context>
    <context id="i8c35be238f5f4799bbc1031e24efec68_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i132a6a890ed4471ba8dcfb3ace9549a0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i3069e6dc112c4ef2a9cf5ab7ee50048d_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib61cc1114176418598c990b41c9592be_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i2fe58c083e874cab83a78bcd827e2e5f_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1b4d2c43bec54742920bd9ad32b07e48_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i30473976e3b8481aa885bb1335a889ba_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i6012dd95b4ab4dde814d5a046166d09c_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1baadb28e8b3408fa30ff77e00eec512_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1941637101594a8cabf4ba0b5e120f5e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ib4c3c6fac973483badc44a66252c9222_I20151231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2015-12-31</instant>
        </period>
    </context>
    <context id="iee4b70d2241e4511bad0987b2b407f03_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ie61370b969e74487b411b5a782a4d5a1_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i8bfcb6d6abee4192bca4732758d746b7_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ife3a9602a0cc4ec79c3b2bda40aa033e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i62bcebfbe2964b9da317b06464c29f89_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:WarrantMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="iee6fe34449294b25881d8dbef0b24b9a_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1c52c13365f3461ab55087c232b51f23_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i0061c212e5ce4c66940a7702790b784e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i570e675c9bf14c37b7f85f189f5c58ec_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i2ae9df4c8cc94d689af9eb73b9a9fceb_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i221c7262300e453ebd7dc80f8dc71c46_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i63575e7ad8594216a6892afca9a80932_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i5c6283c43ebd4c50aa4fe656936d6b4b_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCrystalMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ia7a3efe3d1124d26b92d141e512095a0_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i9bb6c8e4586348ad8838a58f65c26246_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i6a51c585db8547f0acb66bf4eb5290b7_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i929b0893ee4f41fba2a2db7c8914d4f5_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyCydexMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i0ad5f3f765e1490fa0521acd9849999d_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i73c27a6035d749d5b1f296f7edb8ca72_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ic453e34dcee74d5d9343bfeb6edf1581_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i9a3fec8ff6854321a38379f92429618c_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForContingentValueRightsCompanyMetabasisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i00244b874b5f4b12a47e76b73be3fabf_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i928d1de786ce437ebcfc3e3082b3f1b9_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel1Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i107301a7878e4cf4938d9121959d04a0_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel2Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i0d5efee5821c41c0a5ea3977d0964f60_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByFairValueHierarchyLevelAxis">us-gaap:FairValueInputsLevel3Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByLiabilityClassAxis">lgnd:LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ifa4d91631dbf46cc83d6a025d8915d6e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByAssetClassAxis">us-gaap:NotesReceivableMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FairValueByMeasurementFrequencyAxis">us-gaap:FairValueMeasurementsRecurringMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:MeasurementInputTypeAxis">us-gaap:MeasurementInputPriceVolatilityMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ib09e4721ddef410299f0bd0c417261ed_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="icd248d584f1346b5b66dd780d1e9928a_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:Phase3ClinicalTrialMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ice0efd7fd9d64d719b062c5b9df1406e_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">lgnd:MilestonePaymentsAndRoyaltiesMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:TimingOfTransferOfGoodOrServiceAxis">us-gaap:TransferredOverTimeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i921201b66b074388aa32f960d2db10cc_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i1a2836d1fbd04b178ed87e38468a92c5_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ice45c867198c4943b2d8c9ed9f84c1df_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexandCrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i90f8a9db2c664665a84b2f5fadf055a6_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:CorporateHeadquartersSanDiegoCAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i9c0a19e6fade4506a5851714e59f5e3e_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeandResearchFacilityLaJollaCAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i883212435cba47509b8b8d099bf0e1ca_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:BioscienceandTechnologyBusinessCenterLawrenceKSMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:KS</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ifa49963bd5424932b50d46aad0ed712f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeEmeryvilleCAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i6e55f210c9ac49b5987a4861064c949d_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:ResearchFacilityEmeryvilleCAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">stpr:CA</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i354c535302b44bb19e10fe3b5a010cc8_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:OfficeWinnershUnitedKingdomMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">country:GB</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ic340228d81314653a2c316604b50c401_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis">lgnd:ResearchFacilityCambridgeUnitedKingdomMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:StatementGeographicalAxis">country:GB</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2014-08-01</startDate>
            <endDate>2014-08-31</endDate>
        </period>
    </context>
    <context id="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodOneMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2014-08-01</startDate>
            <endDate>2014-08-31</endDate>
        </period>
    </context>
    <context id="i83e610145e1441a4a48edbf5a5efb62b_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodTwoMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2014-08-01</startDate>
            <endDate>2014-08-31</endDate>
        </period>
    </context>
    <context id="ic6a1014c54c4494f865d0272345aab6a_D20180522-20180522">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-22</startDate>
            <endDate>2018-05-22</endDate>
        </period>
    </context>
    <context id="i69c23a1e2fbe4523a3ca4deec08a3872_D20181231-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-12-31</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-03-01</startDate>
            <endDate>2018-04-30</endDate>
        </period>
    </context>
    <context id="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-07-01</startDate>
            <endDate>2018-08-31</endDate>
        </period>
    </context>
    <context id="i75f0350fef6541038e98f82afd43a2f1_D20181001-20181130">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-10-01</startDate>
            <endDate>2018-11-30</endDate>
        </period>
    </context>
    <context id="i37074bf992d247a491292198d0359ff0_I20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2014-08-31</instant>
        </period>
    </context>
    <context id="i98d8d53ba8784c41bea403e9d3429ff2_D20140801-20140831">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2014-08-01</startDate>
            <endDate>2014-08-31</endDate>
        </period>
    </context>
    <context id="i7da8d16c399b44818efd38241c41af9b_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="icf42ad343571467faece802b998bf88c_D20181101-20181130">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-11-01</startDate>
            <endDate>2018-11-30</endDate>
        </period>
    </context>
    <context id="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodOneMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-01</startDate>
            <endDate>2018-05-31</endDate>
        </period>
    </context>
    <context id="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentRedemptionPeriodAxis">us-gaap:DebtInstrumentRedemptionPeriodTwoMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-01</startDate>
            <endDate>2018-05-31</endDate>
        </period>
    </context>
    <context id="i978ee51a08364e3eb7649d6141d3c780_D20180522-20180619">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-22</startDate>
            <endDate>2018-06-19</endDate>
        </period>
    </context>
    <context id="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8517c8b0243e45e096978d0ca26893b0_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ia32e2ae420b54b08bc61c77e24a0b664_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i60cd2ff27aee458a876ce61408c2748a_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ie527761fa7b14d4e8c10a419b7c96050_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="iff1b40e31eb94dd28c98c1b69495379f_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i57786fa40fdb47bdb16a704aefea1269_I20180630">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2018-06-30</instant>
        </period>
    </context>
    <context id="i1119817d95d04c2b84b6f21adc149bc8_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="i2fb1a05c9a404a7a9804793a41837e00_D20180501-20180531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:LongtermDebtTypeAxis">us-gaap:ConvertibleNotesPayableMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-05-01</startDate>
            <endDate>2018-05-31</endDate>
        </period>
    </context>
    <context id="if09401cad196425ab690698455cc8c3d_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:DemandDepositsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i68ecb47464af47feb893f53340e5806b_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CorporateDebtSecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i873cc4ad2c4a424094af1f53ee86bf32_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:EquitySecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ide49d3899c314c7a83ca6827111b97cd_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CommercialPaperMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i40f8bac802b34bae87d73215caf27338_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USTreasurySecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="icbfd2d77cfdb42909cec6fea6491ed92_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:MunicipalBondsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ibe5aa361660c49aa9ade65790e60db3b_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i843b12a2426b42a0a044c4840af01886_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:DemandDepositsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CorporateDebtSecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="if8adb73be9d64177a10495f9d227b467_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="i9251dd4d31b7498093e1f44f4c5947dc_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:EquitySecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i314bde6d607f4e658a119ca41affb344_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:CommercialPaperMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i08498294a183499a9bf71fb60b17b954_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USGovernmentAgenciesDebtSecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i9c4120046acd4fc69f355bb557d7c4d1_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:USTreasurySecuritiesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="if120a59cc3604cb3ad3491acaa5c4d79_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:MunicipalBondsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="iac339cad857c45998c60f10b6d6bf7da_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:InvestmentTypeAxis">us-gaap:ShortTermInvestmentsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i16fdeb617d3e4ad69654c02d20dca967_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:OfficeEquipmentMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="iac24af30dd5947d69f092c0143c72cd5_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:OfficeEquipmentMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i4e5237e21cd94cbe8fb403d08bacef1f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:LeaseholdImprovementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i5d2d421f80254076b1c05f7d56f73e55_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">us-gaap:LeaseholdImprovementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i619dc5c14c054866a55684440355f164_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="ic146a47155124f8587de68b7f7bf2916_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">lgnd:ComputerEquipmentAndSoftwareMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i2f59fb3a08394604ad40621952d209ac_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PropertyPlantAndEquipmentByTypeAxis">lgnd:ComputerEquipmentAndSoftwareMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="if00b0dbd22ec4957944d58677bc41590_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IndefiniteLivedIntangibleAssetsByMajorClassAxis">lgnd:AcquiredInProcessResearchAndDevelopmentMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:PatentedTechnologyMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i17da7efba5044964a299fa1b88c45d89_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:PatentedTechnologyMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i25a1b9803d204d8399b4072bc7f1feba_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:TradeNamesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i098eec66c5b3403da1e52d65ba40fb09_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:TradeNamesMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:CustomerRelationshipsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ida0878f2976a419ab990ac37bb697cf4_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:CustomerRelationshipsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ic732878aa6064bd6999a01fcb26ffafb_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="ia2d1a8eee1564d08a05108a7d9f42143_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="i7a2d42893cd644a68777988972f1db82_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="idfb5b3bf1daa4956a0677ba6e2b17a09_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i6555f01d1e2a414bb4602de9db064582_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CydexPharmaceuticalsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i04a307d0dd25404c9e1b6973b4fcfcfc_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="ib90242a1f1084a72890da4139394161b_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i962f4a871df84f71a3762aabb69d87d4_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i5a6f5527bcd749ebb994ee78a83dec16_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i3ddcb2326de24ff388c9dabc96f2f7ab_I20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-12-31</instant>
        </period>
    </context>
    <context id="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ia96387c68e204b4388e9977b060ff288_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i3dc153fa027840bfaf8d39d7777fca8a_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="idaab1982bed149178b9a7a902d4ec9b1_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i5525fb7204b24ebb9a94c522e3490ed3_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i660b0db80fb243a9aa215587f3e20997_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:ResearchAndDevelopmentExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i6387378ce4f1495fbf9934bbc7f8004b_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i008883d729b243ce80c4af9827bf6117_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i9e6c1c39ab414f958545d7f4f2e968ea_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeStatementLocationAxis">us-gaap:GeneralAndAdministrativeExpenseMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i8122f73ad096454d8683e1fb385d450f_D20120530-20120531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2012-05-30</startDate>
            <endDate>2012-05-31</endDate>
        </period>
    </context>
    <context id="i10821c8abf4c413496e40313cc3d82c6_D20160501-20160531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-05-01</startDate>
            <endDate>2016-05-31</endDate>
        </period>
    </context>
    <context id="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="iefc813acbb6448ec99d57a49fe36770e_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:TwoThousandTwoStockIncentivePlanMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i02a0eae6ee8f45419024489126f96d62_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeOneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeOneMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTwoMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ie821bbf2318f4f019ee636621375f551_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTwoMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="iaaac9c476ecc4afaa2ed93f40a060882_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeThreeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeThreeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i188efce7ecde4338afd75e87443c6147_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFourMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFourMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="if74d2c0621f34efba8080e1e9711fb35_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFiveMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeFiveMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia88d9bb235ee4445acd17f3571976ef0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSixMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i92faeba614e34b3493a599209d077a07_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSixMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i161b18328a8442d6997ff80696b788bd_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSevenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeSevenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i4246c537469d483abd783cecc40379d0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeNineMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeNineMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i56fd83bc6dc042639ae1df971a9f4d20_I20170101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-01-01</instant>
        </period>
    </context>
    <context id="i5974c3104a5d4b21bf3baa514858efa2_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeTenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="icd529d0655ba4752b67e7314f7cc06f6_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeEightMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeEightMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="icf71bbc4ad954da9bce0e233b086c8bb_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeElevenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis">lgnd:ExercisePriceRangeElevenMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia0d63b23666041d7a8b08537e54a6d2c_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:EmployeeStockOptionMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="id920233585164484842655792fe0311e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="iaead0586e66545bf9a546304d06af27d_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AwardTypeAxis">us-gaap:RestrictedStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib96266c9cd9e42b68a5de54609fb51bd_I20170101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-01-01</instant>
        </period>
    </context>
    <context id="i5049cfdd90d748e48259538705c3a2a0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ic36cfb515c93422e90d0bdcd8bd0ebee_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i6ec79fc5ae034975bdc7a82825400a68_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:PlanNameAxis">lgnd:AmendedESPPMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-05-01</startDate>
            <endDate>2018-05-31</endDate>
        </period>
    </context>
    <context id="ibb568ab64b614ed6a1e37b60e92b6fef_I20150930">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2015-09-30</instant>
        </period>
    </context>
    <context id="if2c884f969ea4a8c957cc0b0ecc3ad55_I20190123">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2019-01-23</instant>
        </period>
    </context>
    <context id="i0f29d3370c15467eae1d22610a661a7f_D20190101-20190228">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2019-01-01</startDate>
            <endDate>2019-02-28</endDate>
        </period>
    </context>
    <context id="ia523a50a3e1f4636a3f2c5181779d8ee_I20190228">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:SubsequentEventTypeAxis">us-gaap:SubsequentEventMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2019-02-28</instant>
        </period>
    </context>
    <context id="ia5b28253139449d098c85223a0ec523b_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i33d2f89847cf48949592096f2d579f2b_I20170101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201609Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-01-01</instant>
        </period>
    </context>
    <context id="icf48f425fe72411f84259887a606949c_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i8f913262edf243adae4d2f256243ef16_D20150901-20150930">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2015-09-01</startDate>
            <endDate>2015-09-30</endDate>
        </period>
    </context>
    <context id="ie84f0fb144ed4ec5926cfdf7ba32b2bb_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeTaxAuthorityAxis">us-gaap:InternalRevenueServiceIRSMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="if81fb0e1a8ac48909d921d4552f44684_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:IncomeTaxAuthorityAxis">us-gaap:StateAndLocalJurisdictionMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib8f1f80b43fe48948dc666b8a2639468_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:TaxCreditCarryforwardAxis">us-gaap:ResearchMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i1426778bb59d4208adce54ccb7e0983f_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:TaxCreditCarryforwardAxis">lgnd:CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-03-31</endDate>
        </period>
    </context>
    <context id="i629fd315f0344d618e896741a9894704_D20170401-20170630">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2017-04-01</startDate>
            <endDate>2017-06-30</endDate>
        </period>
    </context>
    <context id="i1f9437583206454497ad1119bfadd777_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2017-07-01</startDate>
            <endDate>2017-09-30</endDate>
        </period>
    </context>
    <context id="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2017-10-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="ief940d953eac4033875ea91ff5566b14_D20180101-20180331">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-03-31</endDate>
        </period>
    </context>
    <context id="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-04-01</startDate>
            <endDate>2018-06-30</endDate>
        </period>
    </context>
    <context id="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-07-01</startDate>
            <endDate>2018-09-30</endDate>
        </period>
    </context>
    <context id="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <startDate>2018-10-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ic608cbca1fef42b885a41d66ca7b19bd_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i8b39fe8e03bc43f49fbf934d621cb24c_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i2513fadb593f42d3b8500a28dadd898f_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i16eca74f8d9c46a28663ad714fd5a4b5_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8d92baeda9ac47a986e2a5bd6eacdbf2_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="i7732d073cf4e48638e3a966a3396d67c_I20190225">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2019-02-25</instant>
        </period>
    </context>
    <context id="i3574527256f745d8bcdc0cb4541c738e_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="i86047298eb4f4ea5ba70e04cad22157a_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201601Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="ic7fb939626f5447db0b459d9b7bc82d1_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="i933a7ea4fa9f4cc7bf26d93ee66f026b_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <context id="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ie022521383864c29a350e9f710b3a989_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2019Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:DebtInstrumentAxis">lgnd:ConvertibleSeniorNotes2023Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:CommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ia9f65f9bd2374512bb8783927196d39a_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AdditionalPaidInCapitalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i87420e1b166545afb11eefa8eb1ab74c_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ibcb5b487ee794160bf522b883cfa27c7_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:AccumulatedOtherComprehensiveIncomeMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="id4a587395c674ab4bf495afb6bd1140b_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:StatementEquityComponentsAxis">us-gaap:RetainedEarningsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ibf1a2a4d3d614da2a9e3262a761010bc_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i346f6d3d9c4c4913bcb746295c506010_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i4604c286cb3b4c23b3e7c54016351f4f_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:VikingTherapeuticsInc.Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i38e7892ad1fc44c687187391e73e15ad_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i401746069dc0428bae920f833bd24769_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i152983bb0da8462dbdf2be5c4ba3bc18_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis">lgnd:PurchaseofCommonStockMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i3029e46160e643808e723653c88b6bac_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i223dab5f73e347b9b79caa31f48b5d33_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerAMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="iad54ce0fea834c76ad026f321579313c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i43cdf2b8a77549fda2334e555da01d30_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i966b40b605c54c23a7a845e4be0cfade_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerBMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="i1c82d6eeab5342c98f34c3b8321892fc_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i2153cdb62e2e4f53a2c6274726b9b87a_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i151ec7ab8a8b4a41b242da4ab90bcbae_D20160101-20161231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:MajorCustomersAxis">lgnd:PartnerCMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByBenchmarkAxis">us-gaap:SalesRevenueNetMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:ConcentrationRiskByTypeAxis">us-gaap:CustomerConcentrationRiskMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2016-01-01</startDate>
            <endDate>2016-12-31</endDate>
        </period>
    </context>
    <context id="if9a0fc3b1b494d80a80b515f64915b07_I20171006">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:CrystalMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-10-06</instant>
        </period>
    </context>
    <context id="i269cf529b8f542d6b6e89cfb73d21395_I20100131">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:BusinessAcquisitionAxis">lgnd:MetabasisTherapeuticsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2010-01-31</instant>
        </period>
    </context>
    <context id="i06d7e832be914ea4927e544711c5f918_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoandCorMatrixMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i1714ac5410ad49d586a22807a601a7c8_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoandCorMatrixMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i1b15f9f5711d44a591a3a36a58b9681a_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="if37a84377d584e49a64fd37c3dc17dfb_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="i6a92d032fd254b68a22e68edb0bb484e_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:SelexisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="iea65327226544655a478dc62c46f5a1e_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:SelexisMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="id9810b34412c4c1692e219b8fa0e1127_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:LicensingAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2017-12-31</instant>
        </period>
    </context>
    <context id="ib3eda2c10c4048a7aa0bacbfdfdfbc14_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:ProductOrServiceAxis">us-gaap:RoyaltyMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i8d095d9391b44d2a86b19f26283e7dc2_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MinimumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i9de660fb7aac4b88a7f3df2f717fed6d_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="srt:RangeAxis">srt:MaximumMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i41125f6764344dc486a91d878d152ad5_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:TitleOfIndividualAxis">us-gaap:DirectorMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="dei:LegalEntityAxis">lgnd:PalvellaTherapeuticsIncMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="i4399b7aa92d94af1af9043d8910747e6_D20170101-20171231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2017-01-01</startDate>
            <endDate>2017-12-31</endDate>
        </period>
    </context>
    <context id="i7fc73450defc41569175c47bffd04a31_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i35202cb30da54ce3b43396a39f8f50fd_I20160503">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2016-05-03</instant>
        </period>
    </context>
    <context id="i9ba7c91a27af4a8b9cc9746e85a2d4d0_I20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:CorMatrixMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-12-31</instant>
        </period>
    </context>
    <context id="i7549ea636c7549ba8a48714cecadea82_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:CorMatrixMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="ib11ae4f07611449daceda5854c74bb9c_D20180101-20181231">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="srt:CounterpartyNameAxis">lgnd:AziyoMember</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:FiniteLivedIntangibleAssetsByMajorClassAxis">us-gaap:RoyaltyAgreementsMember</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <startDate>2018-01-01</startDate>
            <endDate>2018-12-31</endDate>
        </period>
    </context>
    <context id="if72b93facdb542d6b9aa3d2def1abd30_I20180101">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0000886163</identifier>
            <segment>
                <xbrldi:explicitMember dimension="us-gaap:AdjustmentsForNewAccountingPronouncementsAxis">us-gaap:AccountingStandardsUpdate201409Member</xbrldi:explicitMember>
                <xbrldi:explicitMember dimension="us-gaap:InitialApplicationPeriodCumulativeEffectTransitionAxis">us-gaap:DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member</xbrldi:explicitMember>
            </segment>
        </entity>
        <period>
            <instant>2018-01-01</instant>
        </period>
    </context>
    <unit id="trading_day">
        <measure>lgnd:trading_day</measure>
    </unit>
    <unit id="numberofcollaborationagreements">
        <measure>lgnd:numberOfCollaborationAgreements</measure>
    </unit>
    <unit id="usd">
        <measure>iso4217:USD</measure>
    </unit>
    <unit id="day">
        <measure>lgnd:day</measure>
    </unit>
    <unit id="shares">
        <measure>shares</measure>
    </unit>
    <unit id="number">
        <measure>pure</measure>
    </unit>
    <unit id="right">
        <measure>lgnd:right</measure>
    </unit>
    <unit id="usdPerShare">
        <divide>
            <unitNumerator>
                <measure>iso4217:USD</measure>
            </unitNumerator>
            <unitDenominator>
                <measure>shares</measure>
            </unitDenominator>
        </divide>
    </unit>
    <dei:EntityRegistrantName
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMS0xLTEtMS0w_664372ef-abc9-41e2-991e-306c3507328b">LIGAND PHARMACEUTICALS INC</dei:EntityRegistrantName>
    <dei:DocumentPeriodEndDate
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNC0xLTEtMS0w_51835910-f64d-42db-a45c-3525c786aabb">2018-12-31</dei:DocumentPeriodEndDate>
    <dei:AmendmentFlag
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNS0xLTEtMS0w_daac6f94-5b9a-4997-8168-370f63f613d4">false</dei:AmendmentFlag>
    <dei:DocumentFiscalYearFocus
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNi0xLTEtMS0w_a80f2307-60be-4ffd-b2e4-63c2a823b10a">2018</dei:DocumentFiscalYearFocus>
    <dei:DocumentFiscalPeriodFocus
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfNy0xLTEtMS0w_61e44828-3c70-4c41-922e-ceccdbf68858">FY</dei:DocumentFiscalPeriodFocus>
    <dei:EntityFilerCategory
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfOS0xLTEtMS0w_1e6642e5-0764-4b98-b2d4-1694ae72d00e">Large Accelerated Filer</dei:EntityFilerCategory>
    <dei:EntityEmergingGrowthCompany
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTAtMS0xLTEtMA_5f64c1cb-760b-4ced-9508-eefea73811db">false</dei:EntityEmergingGrowthCompany>
    <dei:EntitySmallBusiness
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTEtMS0xLTEtMA_eab3232e-9ea5-4f3a-917d-1fdf74c983b3">false</dei:EntitySmallBusiness>
    <dei:EntityShellCompany
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTItMS0xLTEtNTkzMQ_eac89285-89f5-46d1-94d8-0255b82d2567">false</dei:EntityShellCompany>
    <dei:EntityVoluntaryFilers
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTQtMS0xLTEtMA_f722c10e-b5cc-45db-b27e-eba9ffcb3e58">No</dei:EntityVoluntaryFilers>
    <dei:EntityWellKnownSeasonedIssuer
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTUtMS0xLTEtMA_c260cb14-f0ce-4c6e-ae00-cfe039442931">Yes</dei:EntityWellKnownSeasonedIssuer>
    <dei:EntityCurrentReportingStatus
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RhYmxlOjczMDlhNTc1MWE2YTQwMmQ4ZTU1MjU3YmUyNDIzOTdhL3RhYmxlcmFuZ2U6NzMwOWE1NzUxYTZhNDAyZDhlNTUyNTdiZTI0MjM5N2FfMTYtMS0xLTEtMA_76d1e59d-e071-426f-8220-26e2be511690">Yes</dei:EntityCurrentReportingStatus>
    <dei:EntityCentralIndexKey
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RleHRyZWdpb246OGEwM2QzNjAxOTczNGFhYmIzNWQwYmRhYzk5NzNhOTlfMTMxOTQxMzk1MzM0MDI_f6e2abca-af7d-4d80-bc26-b8695f60c6ce">0000886163</dei:EntityCentralIndexKey>
    <dei:CurrentFiscalYearEndDate
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xMy9mcmFnOjhhMDNkMzYwMTk3MzRhYWJiMzVkMGJkYWM5OTczYTk5L3RleHRyZWdpb246OGEwM2QzNjAxOTczNGFhYmIzNWQwYmRhYzk5NzNhOTlfMTMxOTQxMzk1MzM0MDM_cdf962e9-90c8-42ae-921f-b5b9ca8b9251">--12-31</dei:CurrentFiscalYearEndDate>
    <us-gaap:CommonStockParOrStatedValuePerShare
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzItMS0xLTEtMA_7ecb702b-833a-4bc7-9532-2f4b344e3156"
      unitRef="usdPerShare">0.001</us-gaap:CommonStockParOrStatedValuePerShare>
    <us-gaap:CommonStockParOrStatedValuePerShare
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzItMy0xLTEtMA_cae165b3-d3f9-4335-9bed-7484d05caf24"
      unitRef="usdPerShare">0.001</us-gaap:CommonStockParOrStatedValuePerShare>
    <us-gaap:CommonStockSharesAuthorized
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzMtMS0xLTEtMA_bd9bedfa-bcbe-493e-a07b-ed679a5aee4b"
      unitRef="shares">60000000</us-gaap:CommonStockSharesAuthorized>
    <us-gaap:CommonStockSharesAuthorized
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzMtMy0xLTEtMA_13042ee9-ff33-4470-b54e-084866506589"
      unitRef="shares">33333333</us-gaap:CommonStockSharesAuthorized>
    <us-gaap:CommonStockSharesIssued
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzQtMS0xLTEtMA_7f02baec-28b7-4927-a6d6-abcac52c706e"
      unitRef="shares">20765533</us-gaap:CommonStockSharesIssued>
    <us-gaap:CommonStockSharesIssued
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzQtMy0xLTEtMA_2673b5df-ce33-45c6-88da-3d5b5258750c"
      unitRef="shares">21148665</us-gaap:CommonStockSharesIssued>
    <us-gaap:CommonStockSharesOutstanding
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzUtMS0xLTEtMA_1a885dff-7d6a-40f8-9e68-34a52d3414c0"
      unitRef="shares">20765533</us-gaap:CommonStockSharesOutstanding>
    <us-gaap:CommonStockSharesOutstanding
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yODMvZnJhZzpiZTU1YWZmMjUwYmM0NTFhOWNhZTJhNjdjMDI0NmMzZi90YWJsZTplOTM5Y2M2ZjQyZDk0NTE0OTc1YzE0MGI5ZTkwNzQ1NC90YWJsZXJhbmdlOmU5MzljYzZmNDJkOTQ1MTQ5NzVjMTQwYjllOTA3NDU0XzUtMy0xLTEtMA_7d3173a5-cbb3-454e-8131-f94f57caf302"
      unitRef="shares">21148665</us-gaap:CommonStockSharesOutstanding>
    <us-gaap:InventoryWriteDown
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTo1NDQwMWExOWJiNTE0MjUzOGYzNTY0NzM1OTFlNWQ4Yi90YWJsZXJhbmdlOjU0NDAxYTE5YmI1MTQyNTM4ZjM1NjQ3MzU5MWU1ZDhiXzEtMy0xLTEtMA_c4025e9d-b14e-42c6-b228-0bc2425d6627"
      unitRef="usd">0</us-gaap:InventoryWriteDown>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage
      contextRef="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpmOTI1ZTQ3NWQyODc0YTgzOTdjMzZlZDI0YmNlMmEzMy90YWJsZXJhbmdlOmY5MjVlNDc1ZDI4NzRhODM5N2MzNmVkMjRiY2UyYTMzXzEtMS0xLTEtMA_85aefc79-c26a-4e68-8286-9816c3eb4260"
      unitRef="number">0.1250</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage
      contextRef="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpmOTI1ZTQ3NWQyODc0YTgzOTdjMzZlZDI0YmNlMmEzMy90YWJsZXJhbmdlOmY5MjVlNDc1ZDI4NzRhODM5N2MzNmVkMjRiY2UyYTMzXzItMS0xLTEtMA_b07a7536-f8cd-4c6f-8126-57b140ba95e9"
      unitRef="number">0.0208</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage>
    <lgnd:ThresholdBusinessDaysforRepaymentofPrincipal
      contextRef="i2ba96270f73845a489eec892606f151e_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5NA_96a7094d-2abf-46bb-8478-1d9d9dc4f0f5">P3D</lgnd:ThresholdBusinessDaysforRepaymentofPrincipal>
    <us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
      contextRef="i2ba96270f73845a489eec892606f151e_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5NQ_8697301c-ec04-48fc-b7e3-21d65ad9278a"
      unitRef="trading_day">50</us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1>
    <lgnd:MaturityPeriodOfHighlyLiquidSecuritiesMaximum
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5Ng_29ab42d8-1579-4e92-a54e-4606d62246ea">P3M</lgnd:MaturityPeriodOfHighlyLiquidSecuritiesMaximum>
    <us-gaap:PropertyPlantAndEquipmentUsefulLife
      contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5Nw_617acb72-a5b3-420b-a338-e89ea52c5adf">P3Y</us-gaap:PropertyPlantAndEquipmentUsefulLife>
    <us-gaap:PropertyPlantAndEquipmentUsefulLife
      contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5OA_5c37b17a-8f28-4afb-8fe2-a519e0efdd0b">P10Y</us-gaap:PropertyPlantAndEquipmentUsefulLife>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1
      contextRef="ibf004708a8b44222aebfb0258f343fb3_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzY5OQ_ba2308d5-a410-47a8-8243-66ff1e3dddf5">P6M</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1
      contextRef="i28eb504e64434b9da2b8ceaf87993174_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzcwMA_fed73d4b-9cb6-418d-a1f0-f37e607d4d27">P42M</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i0aadecee51e54de98ac550079bea27c4_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMS0xLTEtNzkwMA_324e00e1-3ace-43b7-a0c4-01f16d0b05b2"
      unitRef="number">0.3</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i064e8a313dcd4597a31a3e322d0fb198_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMi0xLTEtNzkwMg_e9e84686-113d-47dd-a455-c67005ae89c6"
      unitRef="number">0.35</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="ia1016c7a3fb3456dadccac23f7e35a59_I20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtMy0xLTEtNzkwNA_03605559-c4d1-4028-b078-37a9f108e38e"
      unitRef="number">0.3</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i5be21f383f784dc5bdb8f26fd11bd5f8_I20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzMtNC0xLTEtNzkwNg_48784cf2-0547-46aa-bddf-8dacb2ab478e"
      unitRef="number">0.35</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="id3f44e4150824aac8cb8233b4f6c5332_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMS0xLTEtNzkxMw_5cb6e46b-da75-4e05-85ac-f6177929b87d"
      unitRef="number">0.3</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i4a4309c3a4644756b0b0e2a41966e07d_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMi0xLTEtNzkxMQ_b7ed2a1c-f724-4e35-8b42-9a4a08838b13"
      unitRef="number">0.35</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i019545928c8d42fa914265e7cce06db4_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctMy0xLTEtNzkxMA_fe6ce941-f8ca-47a2-9ec6-ac0b828b676f"
      unitRef="number">0.3</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i421c6d753d8042d6ba4f5dea715b2015_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90YWJsZTpjNDcwNDYyOTE3OTU0NTljOThjMTU1ZDhlNDA2YzBlNS90YWJsZXJhbmdlOmM0NzA0NjI5MTc5NTQ1OWM5OGMxNTVkOGU0MDZjMGU1XzctNC0xLTEtNzkwOA_3dcca4cb-bba4-4b79-ba7d-3ce2efb5e0f9"
      unitRef="number">0.35</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i3574527256f745d8bcdc0cb4541c738e_I20180101"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzE2NDkyNjc0NDI2NTU_59a57916-c03e-4868-b531-a2b54eba9479"
      unitRef="usd">2700000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:NetCashProvidedByUsedInOperatingActivities
      contextRef="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNzEvZnJhZzplNDNhZDRiYTNiOTE0MGQwYTU2Njk0ZjFmNzNhMDBkNC90ZXh0cmVnaW9uOmU0M2FkNGJhM2I5MTQwZDBhNTY2OTRmMWY3M2EwMGQ0XzE2NDkyNjc0NDI4NTg_992cabfc-4a13-4a7c-8abb-2eb6fbd0d96a"
      unitRef="usd">5000000</us-gaap:NetCashProvidedByUsedInOperatingActivities>
    <us-gaap:DebtInstrumentConvertibleConversionRatio1
      contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NDQvZnJhZzowYzE0NDJmZWNkZmU0MWM5OWZkNjUxYjA4M2RjZGE2Zi90YWJsZTpiZmJmMDIwZDFjNTE0YmVjYmFjOWExYzQ5ODdhZTkyMy90YWJsZXJhbmdlOmJmYmYwMjBkMWM1MTRiZWNiYWM5YTFjNDk4N2FlOTIzXzItMS0xLTEtMA_5aaea6fc-5d62-4657-b242-643cbcfe79f7"
      unitRef="number">0.0133251</us-gaap:DebtInstrumentConvertibleConversionRatio1>
    <us-gaap:DebtInstrumentConvertibleConversionRatio1
      contextRef="i2fb1a05c9a404a7a9804793a41837e00_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NDQvZnJhZzowYzE0NDJmZWNkZmU0MWM5OWZkNjUxYjA4M2RjZGE2Zi90YWJsZTpiZmJmMDIwZDFjNTE0YmVjYmFjOWExYzQ5ODdhZTkyMy90YWJsZXJhbmdlOmJmYmYwMjBkMWM1MTRiZWNiYWM5YTFjNDk4N2FlOTIzXzItMi0xLTEtOTA3MA_083b8786-38a3-416d-8c3e-14d2dc6a559a"
      unitRef="number">0.0040244</us-gaap:DebtInstrumentConvertibleConversionRatio1>
    <us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzItMS0xLTEtMA_ccc465b3-fe26-48ba-8742-5936629c6f83"
      unitRef="usd">12800000</us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo>
    <us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzMtMS0xLTEtMA_89127199-1222-4456-9ee3-abb88d3ec68c"
      unitRef="usd">12800000</us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearThree>
    <us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzQtMS0xLTEtMA_6a6750cd-49dd-47e5-accf-66d4bc325b00"
      unitRef="usd">12800000</us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFour>
    <us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFive
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzUtMS0xLTEtOTAxNw_d8a39809-3da4-4ff8-83b4-cd81537f0aab"
      unitRef="usd">12800000</us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseYearFive>
    <us-gaap:ImpairmentOfIntangibleAssetsFinitelived
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzgtMS0xLTEtMA_62e0d75b-c661-4caf-b6c5-cf32a6e82d06"
      unitRef="usd">0</us-gaap:ImpairmentOfIntangibleAssetsFinitelived>
    <us-gaap:ImpairmentOfIntangibleAssetsFinitelived
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90YWJsZTo4NTBiN2ZmMDdhNWY0MjMxYjRjZTNiNGVhN2YwNTY5OS90YWJsZXJhbmdlOjg1MGI3ZmYwN2E1ZjQyMzFiNGNlM2I0ZWE3ZjA1Njk5XzgtMi0xLTEtMA_1df3d65b-ba4c-473a-9538-7b2f8df72cdf"
      unitRef="usd">0</us-gaap:ImpairmentOfIntangibleAssetsFinitelived>
    <us-gaap:PropertyPlantAndEquipmentUsefulLife
      contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90ZXh0cmVnaW9uOjMwZGE0MmZmNmQ0NTQ5MmNhNDk4OWVjMTQzZDAxNmZkXzE2Ng_85c08209-0071-4b50-bfac-6e8bb1f6f9ab">P3Y</us-gaap:PropertyPlantAndEquipmentUsefulLife>
    <us-gaap:PropertyPlantAndEquipmentUsefulLife
      contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NjkvZnJhZzozMGRhNDJmZjZkNDU0OTJjYTQ5ODllYzE0M2QwMTZmZC90ZXh0cmVnaW9uOjMwZGE0MmZmNmQ0NTQ5MmNhNDk4OWVjMTQzZDAxNmZkXzE2Nw_764dca8e-a408-4556-80a9-18fa16b12ce0">P10Y</us-gaap:PropertyPlantAndEquipmentUsefulLife>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMS0xLTEtMA_52090cec-3cd7-4ab0-a036-66bb95f80a09"
      unitRef="number">0.027</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMi0xLTEtMA_54253374-6ab6-4ab9-946e-c4d830f075ef"
      unitRef="number">0.02</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzMtMy0xLTEtMA_4a774be2-0796-4315-8660-345c675050f3"
      unitRef="number">0.013</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMS0xLTEtMA_b3f7c563-9920-49ae-8fab-2dc384204213"
      unitRef="number">0.03</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMi0xLTEtMA_c245a9a2-5fe6-4142-8f1e-c6b3b58684b3"
      unitRef="number">0.022</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate
      contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzQtMy0xLTEtMA_871a4a92-f131-4eac-b559-2a3768db9eaa"
      unitRef="number">0.019</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMS0xLTEtMA_41b7a74c-fc92-4ffe-8a76-7b7da05fd0b6"
      unitRef="number">0.33</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMi0xLTEtMA_d7b54d11-f42a-4868-bc92-b5c84c594612"
      unitRef="number">0.43</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzUtMy0xLTEtMA_41329bfa-d72f-41e5-8271-c7673520bc18"
      unitRef="number">0.48</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMS0xLTEtMA_f5362512-9dc3-4936-aeeb-c06f322150a8"
      unitRef="number">0.36</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMi0xLTEtMA_0b2eee2e-23e1-4c79-9b35-5690abc9027e"
      unitRef="number">0.47</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate
      contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzYtMy0xLTEtMA_1eeaf3eb-d012-4ab5-aec4-d3a9173ca48c"
      unitRef="number">0.50</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="i8e1c1406ecce42ecb5f1d0dcb210aa63_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMS0xLTEtMA_2d4d82ad-e822-40ef-bd58-fdb05d4f5ce0">P5Y1M6D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="ia5b28253139449d098c85223a0ec523b_D20170101-20171231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMi0xLTEtMA_1e86d94f-ab3f-4f1f-8921-8bc0469e5850">P6Y6M</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="icf48f425fe72411f84259887a606949c_D20160101-20161231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzgtMy0xLTEtODk2NQ_64a8f7ae-9a52-40ca-a4ce-542f531f2087">P6Y7M6D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="ia61766d6eb884a369db5d8a965302f49_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMS0xLTEtMA_9c4b0b1b-c687-4947-8e6c-2ace46b198c4">P5Y9M18D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="i2a581e16f3c04510805e7a7d35045adf_D20170101-20171231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMi0xLTEtMA_39a7e4df-e240-4045-a00d-bb925f913494">P6Y9M18D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1
      contextRef="i34870dfa94d14d9c9526f29a2b85b30a_D20160101-20161231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTpiNmExOGIxMmE1YjI0ZjU1YmY0YTAxYzRjY2RhODZhZi90YWJsZXJhbmdlOmI2YTE4YjEyYTViMjRmNTViZjRhMDFjNGNjZGE4NmFmXzktMy0xLTEtODk2Nw_530e085b-b3d6-4136-bae4-906e8475d861">P6Y8M12D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEtMi0xLTEtMA_0842c184-af4c-4ca0-8e46-16bc4652cced"
      unitRef="usdPerShare">8.58</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEtNC0xLTEtMA_ab41b3fe-997e-48ea-8928-491ac26b448e"
      unitRef="usdPerShare">10.05</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzItMi0xLTEtMA_f4c60c03-1629-4be2-bd37-f1b45a043d02"
      unitRef="usdPerShare">10.12</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzItNC0xLTEtMA_a3f13b85-a825-43b8-a674-055105878342"
      unitRef="usdPerShare">12.81</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzMtMi0xLTEtMA_cfb5092a-5bae-4fc1-9af7-0428ce891c85"
      unitRef="usdPerShare">14.47</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzMtNC0xLTEtMA_25eae8fd-a365-4978-9bea-b794040271af"
      unitRef="usdPerShare">14.47</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzQtMi0xLTEtMA_0ccda0f1-aea1-406b-9070-4c9dbc8c82ff"
      unitRef="usdPerShare">16.14</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzQtNC0xLTEtMA_98549fa1-7523-4bbc-a661-05d76d8c63ef"
      unitRef="usdPerShare">17.88</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzUtMi0xLTEtMA_8c2f0671-4151-4281-b001-ee434f102c7b"
      unitRef="usdPerShare">21.92</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzUtNC0xLTEtMA_24a5af42-52ef-42a0-abfa-d5428854bfd4"
      unitRef="usdPerShare">21.92</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzYtMi0xLTEtMA_63b8a1dc-7c40-4954-85ca-46b57069d72e"
      unitRef="usdPerShare">32.00</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzYtNC0xLTEtMA_9d9aa1d7-eb5f-448f-8887-0efb520d3fd4"
      unitRef="usdPerShare">56.26</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzctMi0xLTEtMA_3a8eade5-8ae5-4949-a252-d7f95a581686"
      unitRef="usdPerShare">63.58</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzctNC0xLTEtMA_5abc0b6a-ec2a-47f5-8825-6e7275932fea"
      unitRef="usdPerShare">67.53</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzgtMi0xLTEtMA_d6a4c37d-6e86-4fbb-92a8-38bdf6bcea88"
      unitRef="usdPerShare">74.42</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzgtNC0xLTEtMA_84f4f14c-2243-45ee-93cf-617172f4164d"
      unitRef="usdPerShare">74.42</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzktMi0xLTEtMA_779dee8b-437c-448c-af34-428865da0ddc"
      unitRef="usdPerShare">85.79</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzktNC0xLTEtMA_68fcc4ff-2b17-44bc-97ac-06521f18d7e7"
      unitRef="usdPerShare">100.38</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEwLTItMS0xLTA_cc761a62-43fa-4761-80bd-9b47f692aa51"
      unitRef="usdPerShare">101.15</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzEwLTQtMS0xLTA_e9861da8-43ab-4d3f-a0dc-dbe9c65005d3"
      unitRef="usdPerShare">195.91</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit
      contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzExLTItMS0xLTA_5cab3298-642b-45db-a1e7-d31f9b70ddd4"
      unitRef="usdPerShare">8.58</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit
      contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90YWJsZTo1YzEzNTE2NjAwZGE0YmNkOGNhMTQ1ODAyMzUzOTI0OS90YWJsZXJhbmdlOjVjMTM1MTY2MDBkYTRiY2Q4Y2ExNDU4MDIzNTM5MjQ5XzExLTQtMS0xLTA_e043ff86-d033-4158-b166-1ea8582ab7b6"
      unitRef="usdPerShare">195.91</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit>
    <us-gaap:StockRepurchaseProgramPeriodInForce1
      contextRef="i8f913262edf243adae4d2f256243ef16_D20150901-20150930"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80OTQvZnJhZzpiZGYxZGY3MDllZDI0OGIwYTcyMTk2ZTA1ZmRlMTgxOS90ZXh0cmVnaW9uOmJkZjFkZjcwOWVkMjQ4YjBhNzIxOTZlMDVmZGUxODE5XzI4Ng_e219895e-5989-436f-8943-e2a9d49e7c09">P3Y</us-gaap:StockRepurchaseProgramPeriodInForce1>
    <dei:DocumentType
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y18xMzE5NDEzOTUzNzgxOQ_2f9ba401-e386-407e-a595-4ff50d630194">10-K</dei:DocumentType>
    <dei:EntityPublicFloat
      contextRef="i57786fa40fdb47bdb16a704aefea1269_I20180630"
      decimals="-8"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y181NDk3NTU4MTgzNDY_77fa71da-cd78-436d-9549-96c81c6550e0"
      unitRef="usd">3600000000</dei:EntityPublicFloat>
    <dei:EntityCommonStockSharesOutstanding
      contextRef="i7732d073cf4e48638e3a966a3396d67c_I20190225"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8xL2ZyYWc6NTI3MWQyMGZmMmExNDY3NTlmYzNlMWY0MDE0ZGQyN2MvdGV4dHJlZ2lvbjo1MjcxZDIwZmYyYTE0Njc1OWZjM2UxZjQwMTRkZDI3Y181NDk3NTU4MTgyMzA_4507b81a-665b-4980-b218-1c07d8243df3"
      unitRef="shares">20445407</dei:EntityCommonStockSharesOutstanding>
    <us-gaap:CashAndCashEquivalentsAtCarryingValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQtMS0xLTEtMA_adefee13-5bb6-4c01-a290-257d06784da9"
      unitRef="usd">117164000</us-gaap:CashAndCashEquivalentsAtCarryingValue>
    <us-gaap:CashAndCashEquivalentsAtCarryingValue
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQtMy0xLTEtMA_c7ee5f7c-67de-4af7-bc99-614adc15c5f2"
      unitRef="usd">20620000</us-gaap:CashAndCashEquivalentsAtCarryingValue>
    <us-gaap:ShortTermInvestments
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzUtMS0xLTEtMA_b623dad8-7d48-45ff-a40c-0386715f2715"
      unitRef="usd">601217000</us-gaap:ShortTermInvestments>
    <us-gaap:ShortTermInvestments
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzUtMy0xLTEtMA_e1231891-e06f-45b6-abc1-90bf3337b36f"
      unitRef="usd">181041000</us-gaap:ShortTermInvestments>
    <us-gaap:EquitySecuritiesFvNi
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMS0xLTEtMTUyNTg_6c406f9e-1221-430f-a569-76784fc52117"
      unitRef="usd">46191000</us-gaap:EquitySecuritiesFvNi>
    <us-gaap:EquitySecuritiesFvNi
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMy0xLTEtMTUyNDg_46fd28ea-a9c1-4b8c-98af-6be52d9992cf"
      unitRef="usd">0</us-gaap:EquitySecuritiesFvNi>
    <us-gaap:ReceivablesNetCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMS0xLTEtMA_423f4201-a19d-458a-88a3-7be619a5f686"
      unitRef="usd">55850000</us-gaap:ReceivablesNetCurrent>
    <us-gaap:ReceivablesNetCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzYtMy0xLTEtMA_e3ffe6ae-8245-4594-97e6-d386bfc761c9"
      unitRef="usd">25596000</us-gaap:ReceivablesNetCurrent>
    <us-gaap:NotesAndLoansReceivableGrossCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzctMS0xLTEtMA_6a3d2301-cbaf-4344-a10a-d7358932fb19"
      unitRef="usd">0</us-gaap:NotesAndLoansReceivableGrossCurrent>
    <us-gaap:NotesAndLoansReceivableGrossCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzctMy0xLTEtMA_f12346f1-042d-46ba-b165-101c44ef2eb7"
      unitRef="usd">3877000</us-gaap:NotesAndLoansReceivableGrossCurrent>
    <us-gaap:InventoryNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzgtMS0xLTEtMA_84327058-f936-44e5-8300-dfc80a354bf3"
      unitRef="usd">7124000</us-gaap:InventoryNet>
    <us-gaap:InventoryNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzgtMy0xLTEtMA_9dc62853-130f-4ba7-9a3c-15eba8b4a984"
      unitRef="usd">4373000</us-gaap:InventoryNet>
    <us-gaap:DerivativeAssetsCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMS0xLTEtMTMyNg_12291bca-9d33-4663-b5a8-90816e3e1c88"
      unitRef="usd">22576000</us-gaap:DerivativeAssetsCurrent>
    <us-gaap:DerivativeAssetsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMTMyOA_2cbc21fe-77a2-4abc-9aa2-be2851b40909"
      unitRef="usd">0</us-gaap:DerivativeAssetsCurrent>
    <us-gaap:DerivativeAssetsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMTMyOA_7533d16c-789e-4f51-8df8-a821eddac2c5"
      unitRef="usd">0</us-gaap:DerivativeAssetsCurrent>
    <us-gaap:OtherAssetsCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMS0xLTEtMA_c7da0178-7c95-4ba4-b023-cf643ee72e47"
      unitRef="usd">20418000</us-gaap:OtherAssetsCurrent>
    <us-gaap:OtherAssetsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzktMy0xLTEtMA_06ee93ec-b8a5-4868-b9d3-1f4653f68cbf"
      unitRef="usd">1514000</us-gaap:OtherAssetsCurrent>
    <us-gaap:AssetsCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEwLTEtMS0xLTA_999226cb-e229-4bb4-8576-b42bff6f071a"
      unitRef="usd">870540000</us-gaap:AssetsCurrent>
    <us-gaap:AssetsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEwLTMtMS0xLTA_58f0cb25-ed28-4c15-b0ae-5ffd2b6358ed"
      unitRef="usd">237021000</us-gaap:AssetsCurrent>
    <us-gaap:DeferredIncomeTaxAssetsNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzExLTEtMS0xLTA_1fc0b6ad-1b07-4c0e-9d3f-26a6605d528c"
      unitRef="usd">46521000</us-gaap:DeferredIncomeTaxAssetsNet>
    <us-gaap:DeferredIncomeTaxAssetsNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzExLTMtMS0xLTA_646302e6-3558-4b82-80a3-f389064cb133"
      unitRef="usd">84422000</us-gaap:DeferredIncomeTaxAssetsNet>
    <us-gaap:EquityMethodInvestments
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEyLTEtMS0xLTA_3a9b8022-bd57-4a7a-b956-a55a74f53c1e"
      unitRef="usd">0</us-gaap:EquityMethodInvestments>
    <us-gaap:EquityMethodInvestments
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEyLTMtMS0xLTA_d0ae4409-3fe3-49c0-a137-17d43795131f"
      unitRef="usd">6438000</us-gaap:EquityMethodInvestments>
    <us-gaap:IntangibleAssetsNetExcludingGoodwill
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEzLTEtMS0xLTA_329972b9-349c-449c-b397-e305bb709174"
      unitRef="usd">219793000</us-gaap:IntangibleAssetsNetExcludingGoodwill>
    <us-gaap:IntangibleAssetsNetExcludingGoodwill
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzEzLTMtMS0xLTA_fab1a804-64d8-4d9b-8ee8-5482c38f0ab9"
      unitRef="usd">228584000</us-gaap:IntangibleAssetsNetExcludingGoodwill>
    <us-gaap:Goodwill
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE0LTEtMS0xLTA_b9691fe3-11c3-4ce3-9ea7-ed45dc90a7ca"
      unitRef="usd">86646000</us-gaap:Goodwill>
    <us-gaap:Goodwill
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE0LTMtMS0xLTA_167f4bb4-6490-4a32-a0ec-1cd08a7f9b2b"
      unitRef="usd">85959000</us-gaap:Goodwill>
    <lgnd:CommercialLicenseRights
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE1LTEtMS0xLTA_1f836af7-0c9d-49b2-88cf-88153c652598"
      unitRef="usd">31460000</lgnd:CommercialLicenseRights>
    <lgnd:CommercialLicenseRights
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE1LTMtMS0xLTA_2fac83db-bf13-43c0-b40a-d85e61f44be0"
      unitRef="usd">19526000</lgnd:CommercialLicenseRights>
    <us-gaap:PropertyPlantAndEquipmentNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE2LTEtMS0xLTA_b030c8a8-3bd7-470c-a075-c60d9de283a8"
      unitRef="usd">5372000</us-gaap:PropertyPlantAndEquipmentNet>
    <us-gaap:PropertyPlantAndEquipmentNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE2LTMtMS0xLTA_b029a0a0-dcbb-40f4-aabd-758dc1b4f003"
      unitRef="usd">4212000</us-gaap:PropertyPlantAndEquipmentNet>
    <us-gaap:OtherAssetsNoncurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE3LTEtMS0xLTA_b4cd128c-f8d0-4109-975f-0d472b6dd033"
      unitRef="usd">471000</us-gaap:OtherAssetsNoncurrent>
    <us-gaap:OtherAssetsNoncurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE3LTMtMS0xLTA_20f17531-4baf-469c-8753-b6aa5ea0b654"
      unitRef="usd">4859000</us-gaap:OtherAssetsNoncurrent>
    <us-gaap:Assets
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE4LTEtMS0xLTA_eda5ad33-9f69-4ae1-bff0-0635044a21f6"
      unitRef="usd">1260803000</us-gaap:Assets>
    <us-gaap:Assets
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzE4LTMtMS0xLTA_f04d3ccd-57cd-4604-b4bc-b8b0d984a5c7"
      unitRef="usd">671021000</us-gaap:Assets>
    <us-gaap:AccountsPayableCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIxLTEtMS0xLTA_1802ef8b-a847-48c8-915d-c8e1be34f0a0"
      unitRef="usd">4183000</us-gaap:AccountsPayableCurrent>
    <us-gaap:AccountsPayableCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIxLTMtMS0xLTA_919cd12d-f47b-49fb-bcc5-40a0d14465eb"
      unitRef="usd">2259000</us-gaap:AccountsPayableCurrent>
    <us-gaap:AccruedLiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIyLTEtMS0xLTA_438f8fc7-81b3-4570-9435-da2d14b0a6e6"
      unitRef="usd">19200000</us-gaap:AccruedLiabilitiesCurrent>
    <us-gaap:AccruedLiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIyLTMtMS0xLTA_677582e2-63fc-4155-959a-7851a89793e0"
      unitRef="usd">7377000</us-gaap:AccruedLiabilitiesCurrent>
    <lgnd:CurrentPortionOfLiabilityForContingentValueRights
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIzLTEtMS0xLTA_0f0b5c88-1261-4107-b1f0-5ee4277fa575"
      unitRef="usd">5717000</lgnd:CurrentPortionOfLiabilityForContingentValueRights>
    <lgnd:CurrentPortionOfLiabilityForContingentValueRights
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzIzLTMtMS0xLTA_e44c62ca-0a61-4184-8c87-3e4aa402e1e5"
      unitRef="usd">4703000</lgnd:CurrentPortionOfLiabilityForContingentValueRights>
    <us-gaap:ContractWithCustomerLiabilityCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTEtMS0xLTEzMDc_17c46a1e-05a3-48b4-ac81-4803d5e65995"
      unitRef="usd">3286000</us-gaap:ContractWithCustomerLiabilityCurrent>
    <us-gaap:ContractWithCustomerLiabilityCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTMtMS0xLTc3MDY_58d8118f-02c5-4c71-b2dc-651d2d5ee275"
      unitRef="usd">0</us-gaap:ContractWithCustomerLiabilityCurrent>
    <us-gaap:DerivativeLiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTEtMS0xLTEzMTE_fbaa28dd-c2b3-4854-b949-eb59e4ab1077"
      unitRef="usd">23430000</us-gaap:DerivativeLiabilitiesCurrent>
    <us-gaap:DerivativeLiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTMtMS0xLTc3MDg_284033eb-665f-4d1b-b1fb-605fa2e698ee"
      unitRef="usd">0</us-gaap:DerivativeLiabilitiesCurrent>
    <us-gaap:ConvertibleDebtCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTEtMS0xLTA_9aab049b-f22f-4f8a-b2a1-3bcdf4b91dd8"
      unitRef="usd">26433000</us-gaap:ConvertibleDebtCurrent>
    <us-gaap:ConvertibleDebtCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI0LTMtMS0xLTA_b1d8a999-a860-4773-8c67-f91ba5ca13e6"
      unitRef="usd">224529000</us-gaap:ConvertibleDebtCurrent>
    <us-gaap:LiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTEtMS0xLTA_5df9c664-fbc7-48d6-9b82-948ee1032c9e"
      unitRef="usd">82249000</us-gaap:LiabilitiesCurrent>
    <us-gaap:LiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI1LTMtMS0xLTA_cfffe437-fd76-464b-9c1d-aff66e054ccc"
      unitRef="usd">238868000</us-gaap:LiabilitiesCurrent>
    <us-gaap:ConvertibleDebtNoncurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTEtMS0xLTEyOTc_58b34d35-d3b0-4dce-949b-b14bd522f476"
      unitRef="usd">609864000</us-gaap:ConvertibleDebtNoncurrent>
    <us-gaap:ConvertibleDebtNoncurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTMtMS0xLTc3MTA_3279b4db-64b9-4864-8585-2ddf78c941cf"
      unitRef="usd">0</us-gaap:ConvertibleDebtNoncurrent>
    <lgnd:LiabilityForContingentValueRights
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTEtMS0xLTA_6e817c8d-9500-42ae-9273-6fd025b6af59"
      unitRef="usd">6825000</lgnd:LiabilityForContingentValueRights>
    <lgnd:LiabilityForContingentValueRights
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI2LTMtMS0xLTA_d7a642d4-827f-4a7f-af76-3c65309012ca"
      unitRef="usd">9258000</lgnd:LiabilityForContingentValueRights>
    <us-gaap:OtherLiabilitiesNoncurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI4LTEtMS0xLTA_aa40bb3c-e399-44d6-95c6-a2694846c321"
      unitRef="usd">951000</us-gaap:OtherLiabilitiesNoncurrent>
    <us-gaap:OtherLiabilitiesNoncurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI4LTMtMS0xLTA_5cb4dca2-e66a-4f56-ac7b-7accb62855cb"
      unitRef="usd">4248000</us-gaap:OtherLiabilitiesNoncurrent>
    <us-gaap:Liabilities
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTEtMS0xLTA_2ff869dc-061f-4b69-985f-8c7fa45a9b4c"
      unitRef="usd">699889000</us-gaap:Liabilities>
    <us-gaap:Liabilities
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzI5LTMtMS0xLTA_20a718cf-c288-4aff-a61a-3a7f55fbc0b8"
      unitRef="usd">252374000</us-gaap:Liabilities>
    <us-gaap:CommitmentsAndContingencies
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMwLTEtMS0xLTA_bd6a64a3-d61e-4d8e-90b8-8fa9095a811d"
      unitRef="usd"
      xsi:nil="true"/>
    <us-gaap:CommitmentsAndContingencies
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMwLTMtMS0xLTA_a8a8d6f2-8535-4a42-b7db-ab70a161c2aa"
      unitRef="usd"
      xsi:nil="true"/>
    <us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMxLTEtMS0xLTA_d7ea5d61-1a58-4ef3-9c74-5c1f6219e1d6"
      unitRef="usd">0</us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent>
    <us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMxLTMtMS0xLTA_407f035d-5f00-4d96-b30f-d28d1b6e872d"
      unitRef="usd">18859000</us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent>
    <us-gaap:CommonStockValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMzLTEtMS0xLTA_e938d5a8-8216-459b-a9e9-562e5e3630d8"
      unitRef="usd">21000</us-gaap:CommonStockValue>
    <us-gaap:CommonStockValue
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzMzLTMtMS0xLTA_27b61699-4718-48b7-aaae-b9a1ed252a89"
      unitRef="usd">21000</us-gaap:CommonStockValue>
    <us-gaap:AdditionalPaidInCapital
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM0LTEtMS0xLTA_91b776b4-61a3-445d-a9cf-3ce5b8d068e9"
      unitRef="usd">791114000</us-gaap:AdditionalPaidInCapital>
    <us-gaap:AdditionalPaidInCapital
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM0LTMtMS0xLTA_f73c68d4-c7df-4497-a3d3-b3edaebe6f71"
      unitRef="usd">798205000</us-gaap:AdditionalPaidInCapital>
    <us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM1LTEtMS0xLTA_b0080c34-8f4d-43d4-b203-3b14e466f5c6"
      unitRef="usd">-1024000</us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM1LTMtMS0xLTA_3c431476-5e19-4da6-aa8f-f165c97629f1"
      unitRef="usd">2486000</us-gaap:AccumulatedOtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:RetainedEarningsAccumulatedDeficit
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM2LTEtMS0xLTA_66fae316-4228-4acd-bb1e-4fcb8fa34b44"
      unitRef="usd">-229197000</us-gaap:RetainedEarningsAccumulatedDeficit>
    <us-gaap:RetainedEarningsAccumulatedDeficit
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM2LTMtMS0xLTA_cc05fca6-20c7-4058-8ac9-e2f9299c5142"
      unitRef="usd">-400924000</us-gaap:RetainedEarningsAccumulatedDeficit>
    <us-gaap:StockholdersEquity
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM3LTEtMS0xLTA_9eb797ae-549d-4b1a-8775-c2c17049fbc9"
      unitRef="usd">560914000</us-gaap:StockholdersEquity>
    <us-gaap:StockholdersEquity
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzM3LTMtMS0xLTA_ba411127-335e-456e-bc06-3efbab460702"
      unitRef="usd">399788000</us-gaap:StockholdersEquity>
    <us-gaap:LiabilitiesAndStockholdersEquity
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQwLTEtMS0xLTA_eef810f7-a17b-4cf6-8f95-6b69aaaec022"
      unitRef="usd">1260803000</us-gaap:LiabilitiesAndStockholdersEquity>
    <us-gaap:LiabilitiesAndStockholdersEquity
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yNzEvZnJhZzo5MDE4NTNhYjAzMjk0YzU1YmJhZmQ2ZDRiZGRmM2QwZC90YWJsZTphNzliMTU4MWE1ZjA0ZjQ4OTE5MjE5YzFjMGNlNTg0ZC90YWJsZXJhbmdlOmE3OWIxNTgxYTVmMDRmNDg5MTkyMTljMWMwY2U1ODRkXzQwLTMtMS0xLTA_ca8e8ae8-a542-4113-9e79-9c9496645b1c"
      unitRef="usd">671021000</us-gaap:LiabilitiesAndStockholdersEquity>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtMS0xLTEtMA_60e8fd47-b9cb-4b97-a668-3bc1a1724708"
      unitRef="usd">128556000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="id52ed0969c704d12ac017e1b160c1fed_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtMy0xLTEtMA_3a0469f6-96bf-40f8-876e-ac71ded18c58"
      unitRef="usd">88685000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i47f87ffe68104f86a60d18b2b37e6cf3_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMtNS0xLTEtMA_5466c407-1ce9-4b7f-a6ab-086ef0401b08"
      unitRef="usd">59423000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtMS0xLTEtMA_ff639fdb-dea3-4038-91c9-1562e0bd3483"
      unitRef="usd">29123000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtMy0xLTEtMA_229b5fb8-7eef-4caf-8412-617f341dad6c"
      unitRef="usd">22070000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQtNS0xLTEtMA_f431835d-1c44-4fea-97c9-f4d126afa0f7"
      unitRef="usd">22502000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtMS0xLTEtMA_b8df8e9e-8d7c-464b-bb25-b4080bc2e391"
      unitRef="usd">93774000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtMy0xLTEtMA_1b5aa757-0222-4b21-8b6c-8ca2af42dd99"
      unitRef="usd">30347000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i827aa32e6966431f90040e4f23139fce_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzUtNS0xLTEtMA_6ac8c4d5-004b-4033-8681-fdb9e140260f"
      unitRef="usd">27048000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtMS0xLTEtMA_7f9bc803-d267-4c26-a31e-96790fa8d6b6"
      unitRef="usd">251453000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtMy0xLTEtMA_1841e03d-6e06-485a-9887-f7726e0ab7c2"
      unitRef="usd">141102000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzYtNS0xLTEtMA_1e9d8c27-279a-4ef5-83a1-322b25cf96c4"
      unitRef="usd">108973000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:CostOfGoodsAndServicesSold
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtMS0xLTEtMA_4f6d0eaa-7171-4b69-8762-83e7f515072c"
      unitRef="usd">6337000</us-gaap:CostOfGoodsAndServicesSold>
    <us-gaap:CostOfGoodsAndServicesSold
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtMy0xLTEtMA_46a9e05f-3aa3-48d2-a2ca-e5c16743e8f1"
      unitRef="usd">5366000</us-gaap:CostOfGoodsAndServicesSold>
    <us-gaap:CostOfGoodsAndServicesSold
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzgtNS0xLTEtMA_7b78f9a4-1ef7-44d4-a8f0-2fb49ae951ff"
      unitRef="usd">5571000</us-gaap:CostOfGoodsAndServicesSold>
    <us-gaap:CostOfGoodsAndServicesSoldAmortization
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktMS0xLTEtMA_17f6b579-9f39-4cf9-a234-eb723d597b8c"
      unitRef="usd">15792000</us-gaap:CostOfGoodsAndServicesSoldAmortization>
    <us-gaap:CostOfGoodsAndServicesSoldAmortization
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktMy0xLTEtMA_c3cb1454-64f5-49aa-8f8a-9845bcff3c9d"
      unitRef="usd">12120000</us-gaap:CostOfGoodsAndServicesSoldAmortization>
    <us-gaap:CostOfGoodsAndServicesSoldAmortization
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzktNS0xLTEtMA_91ece387-2d1e-47f6-b8bd-b85020c93991"
      unitRef="usd">10643000</us-gaap:CostOfGoodsAndServicesSoldAmortization>
    <us-gaap:ResearchAndDevelopmentExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTEtMS0xLTA_a38a3e7c-ed00-46e6-9d77-085e46359ee4"
      unitRef="usd">27863000</us-gaap:ResearchAndDevelopmentExpense>
    <us-gaap:ResearchAndDevelopmentExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTMtMS0xLTA_87b89b0b-2cc5-4b5f-9d25-58ae5484db2b"
      unitRef="usd">26887000</us-gaap:ResearchAndDevelopmentExpense>
    <us-gaap:ResearchAndDevelopmentExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEwLTUtMS0xLTA_732efccf-8eb0-4d76-89ab-3e185011b6cf"
      unitRef="usd">21221000</us-gaap:ResearchAndDevelopmentExpense>
    <us-gaap:GeneralAndAdministrativeExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTEtMS0xLTA_89a561b0-7eda-4c5b-89ef-0583b77a5693"
      unitRef="usd">37734000</us-gaap:GeneralAndAdministrativeExpense>
    <us-gaap:GeneralAndAdministrativeExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTMtMS0xLTA_06ca60de-7fb6-4460-978d-2e3ee419b440"
      unitRef="usd">28653000</us-gaap:GeneralAndAdministrativeExpense>
    <us-gaap:GeneralAndAdministrativeExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzExLTUtMS0xLTA_f6be5995-d2a2-4219-9c88-26ea853f163b"
      unitRef="usd">27653000</us-gaap:GeneralAndAdministrativeExpense>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTEtMS0xLTA_28f18039-d0b5-48ef-8df7-650a4611a5a9"
      unitRef="usd">87726000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTMtMS0xLTA_61a82c9b-e443-409f-9005-162c34ea85c0"
      unitRef="usd">73026000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEyLTUtMS0xLTA_e410344d-20ad-46cc-a419-9c99ac254388"
      unitRef="usd">65088000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingIncomeLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTEtMS0xLTA_2243966d-1e79-42e8-abc0-de4fbb1e15e0"
      unitRef="usd">163727000</us-gaap:OperatingIncomeLoss>
    <us-gaap:OperatingIncomeLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTMtMS0xLTA_2330e48f-dc67-4696-b295-01874712defb"
      unitRef="usd">68076000</us-gaap:OperatingIncomeLoss>
    <us-gaap:OperatingIncomeLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzEzLTUtMS0xLTA_ecbf1fec-a036-4394-8b0a-24c82366efce"
      unitRef="usd">43885000</us-gaap:OperatingIncomeLoss>
    <us-gaap:EquitySecuritiesFvNiGainLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTEtMS0xLTA_aeac06b1-3631-42c2-9d1d-82f8dae66af1"
      unitRef="usd">50187000</us-gaap:EquitySecuritiesFvNiGainLoss>
    <us-gaap:EquitySecuritiesFvNiGainLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTMtMS0xLTA_172ad412-6354-426a-9448-3d9aa64176fd"
      unitRef="usd">-2048000</us-gaap:EquitySecuritiesFvNiGainLoss>
    <us-gaap:EquitySecuritiesFvNiGainLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE1LTUtMS0xLTA_c2e03bca-269d-414e-ac82-269cc436e269"
      unitRef="usd">-23132000</us-gaap:EquitySecuritiesFvNiGainLoss>
    <us-gaap:InvestmentIncomeNonoperating
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTEtMS0xLTA_3da565f5-5504-43b6-8eaf-e3c01a989ce8"
      unitRef="usd">13999000</us-gaap:InvestmentIncomeNonoperating>
    <us-gaap:InvestmentIncomeNonoperating
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTMtMS0xLTA_be54a2c1-29b3-4e96-941c-01d8a022079b"
      unitRef="usd">2060000</us-gaap:InvestmentIncomeNonoperating>
    <us-gaap:InvestmentIncomeNonoperating
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE2LTUtMS0xLTA_0d18a8f7-9bda-4ded-b133-abc2ee774f96"
      unitRef="usd">664000</us-gaap:InvestmentIncomeNonoperating>
    <us-gaap:InterestExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTEtMS0xLTA_065dc91c-14f9-4558-a878-79d4537cde63"
      unitRef="usd">48276000</us-gaap:InterestExpense>
    <us-gaap:InterestExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTMtMS0xLTA_858f9ff4-87f2-4967-8381-92b990032077"
      unitRef="usd">13460000</us-gaap:InterestExpense>
    <us-gaap:InterestExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE3LTUtMS0xLTA_8fd8b64b-f13d-41a1-a611-7df397eec250"
      unitRef="usd">12842000</us-gaap:InterestExpense>
    <us-gaap:OtherNonoperatingIncomeExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTEtMS0xLTA_5cf7a19b-cbae-452f-971d-54a5f3e68803"
      unitRef="usd">-6307000</us-gaap:OtherNonoperatingIncomeExpense>
    <us-gaap:OtherNonoperatingIncomeExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTMtMS0xLTA_3bacac38-5c48-437e-b37a-49e354ba805d"
      unitRef="usd">2603000</us-gaap:OtherNonoperatingIncomeExpense>
    <us-gaap:OtherNonoperatingIncomeExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE4LTUtMS0xLTA_6bba7ff0-573e-451f-bccb-e7c843895e9f"
      unitRef="usd">-615000</us-gaap:OtherNonoperatingIncomeExpense>
    <us-gaap:NonoperatingIncomeExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTEtMS0xLTc3MTY_0d27ca0a-7c06-4c31-b63d-5eec10e4a593"
      unitRef="usd">9603000</us-gaap:NonoperatingIncomeExpense>
    <us-gaap:NonoperatingIncomeExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTMtMS0xLTc3MTQ_8d902056-1b07-4d29-9653-a984803a6224"
      unitRef="usd">-10845000</us-gaap:NonoperatingIncomeExpense>
    <us-gaap:NonoperatingIncomeExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzE5LTUtMS0xLTc3MTI_cb91bdc5-0e51-4bc5-8c4c-6b2962097533"
      unitRef="usd">-35925000</us-gaap:NonoperatingIncomeExpense>
    <us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTEtMS0xLTc3MTg_a7eb3f7c-d19b-4c7e-b37e-f425394a755d"
      unitRef="usd">173330000</us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments>
    <us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTMtMS0xLTc3MjA_9d264970-40c1-4f11-b2de-6a77d879c62e"
      unitRef="usd">57231000</us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments>
    <us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIwLTUtMS0xLTc3MjI_724ac07d-052e-4bec-a00d-27c3805caafd"
      unitRef="usd">7960000</us-gaap:IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTEtMS0xLTA_2013c6bb-2553-4f93-a07e-082e4d9839d8"
      unitRef="usd">30009000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTMtMS0xLTA_51257573-1878-4b06-9f9e-4cfc524cf37f"
      unitRef="usd">44675000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIyLTUtMS0xLTA_84011968-3aa3-48bc-89dd-bd048b6fdeda"
      unitRef="usd">10327000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTEtMS0xLTA_67f323ec-19f3-4ed3-863d-bf3a3f878dd7"
      unitRef="usd">143321000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTMtMS0xLTA_ba7fa0a5-9ef1-499b-980e-4ace8cc54d06"
      unitRef="usd">12556000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzIzLTUtMS0xLTA_a8eddc8a-d1ee-4bf4-a3d9-58ca8a483372"
      unitRef="usd">-2367000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTEtMS0xLTA_9f671275-6612-418e-b0c8-a73376edf5f1"
      unitRef="usd">0</us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax>
    <us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTMtMS0xLTA_e0c7b96c-b471-4b91-9bb7-035fd968dbd6"
      unitRef="usd">0</us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax>
    <us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI1LTUtMS0xLTA_28c6d95b-46bf-4752-8cbf-9654f58b5da0"
      unitRef="usd">1139000</us-gaap:DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax>
    <us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTEtMS0xLTA_3a002461-b4d0-4b9c-ab1b-7e8e0576c3ae"
      unitRef="usd">0</us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation>
    <us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTMtMS0xLTA_8f311c3a-5383-467b-8bd7-c18cc8e43138"
      unitRef="usd">0</us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation>
    <us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI2LTUtMS0xLTA_5bdaad16-b485-4f1f-b6ba-1ca5629338ab"
      unitRef="usd">408000</us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation>
    <us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTEtMS0xLTA_a4e857b5-b109-481c-b04e-2929865180b7"
      unitRef="usd">0</us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax>
    <us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTMtMS0xLTA_ac2e91f2-9d98-4c1e-aa3a-beb0beb5ac2b"
      unitRef="usd">0</us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax>
    <us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI3LTUtMS0xLTA_8650ac70-3d7a-4263-979c-4287ec7e2056"
      unitRef="usd">731000</us-gaap:DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax>
    <us-gaap:NetIncomeLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTEtMS0xLTA_21314f3a-c7db-4a49-8711-015eae804810"
      unitRef="usd">143321000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTMtMS0xLTA_40d8b174-343e-41f5-9073-42eed2cee6bf"
      unitRef="usd">12556000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzI4LTUtMS0xLTA_d1aef6df-bc51-4cf7-b116-ff229dfaeb31"
      unitRef="usd">-1636000</us-gaap:NetIncomeLoss>
    <us-gaap:IncomeLossFromContinuingOperationsPerBasicShare
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424"
      unitRef="usdPerShare">6.77</us-gaap:IncomeLossFromContinuingOperationsPerBasicShare>
    <us-gaap:IncomeLossFromContinuingOperationsPerBasicShare
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0"
      unitRef="usdPerShare">0.60</us-gaap:IncomeLossFromContinuingOperationsPerBasicShare>
    <us-gaap:IncomeLossFromContinuingOperationsPerBasicShare
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6"
      unitRef="usdPerShare">-0.11</us-gaap:IncomeLossFromContinuingOperationsPerBasicShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7"
      unitRef="usdPerShare">0</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a"
      unitRef="usdPerShare">0</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb"
      unitRef="usdPerShare">0.04</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare>
    <us-gaap:EarningsPerShareBasic
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988"
      unitRef="usdPerShare">6.77</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0"
      unitRef="usdPerShare">0.60</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668"
      unitRef="usdPerShare">-0.08</us-gaap:EarningsPerShareBasic>
    <us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8"
      unitRef="usdPerShare">5.96</us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare>
    <us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648"
      unitRef="usdPerShare">0.53</us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare>
    <us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658"
      unitRef="usdPerShare">-0.11</us-gaap:IncomeLossFromContinuingOperationsPerDilutedShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b"
      unitRef="usdPerShare">0</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5"
      unitRef="usdPerShare">0</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare>
    <us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6"
      unitRef="usdPerShare">0.04</us-gaap:IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare>
    <us-gaap:EarningsPerShareDiluted
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1"
      unitRef="usdPerShare">5.96</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a"
      unitRef="usdPerShare">0.53</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a"
      unitRef="usdPerShare">-0.08</us-gaap:EarningsPerShareDiluted>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTEtMS0xLTA_eacb2c3a-f19d-47f9-bbf1-14763368636a"
      unitRef="shares">21160000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTMtMS0xLTA_66294cc1-4c08-4116-9987-df230a8839a8"
      unitRef="shares">21032000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQzLTUtMS0xLTA_853c5ca3-6830-4dc7-8a16-e6479a4abe44"
      unitRef="shares">20831000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTEtMS0xLTA_da2c18b8-a406-4637-94cf-79e8eef5b081"
      unitRef="shares">24067000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTMtMS0xLTA_97e9ab14-d25d-46cc-ab29-a65cc918cf45"
      unitRef="shares">23481000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQ0LTUtMS0xLTA_ae8fdbfe-28ad-4e35-9be2-a5cefaa461bd"
      unitRef="shares">20831000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:NetIncomeLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItMS0xLTEtMA_68457d23-7a74-4c49-aa9e-808c9df2a44d"
      unitRef="usd">143321000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItMy0xLTEtMA_cfaa18d6-3799-4141-aa0d-9cf06de387de"
      unitRef="usd">12556000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzItNS0xLTEtMA_2b68343f-f555-4eb4-a204-bb18ebda6398"
      unitRef="usd">-1636000</us-gaap:NetIncomeLoss>
    <us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtMS0xLTEtMA_8720599b-b6a5-42f1-a90c-44d636945e8e"
      unitRef="usd">73000</us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtMy0xLTEtMA_d1cd2295-bfca-4295-bd7f-c41144209db6"
      unitRef="usd">143000</us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzMtNS0xLTEtMA_4b467b78-508b-4c28-8c1b-9bf5cd7d7273"
      unitRef="usd">93000</us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMS0xLTEtMTUxNDg_5f74390a-162b-4b7f-8f35-e6e633694f04"
      unitRef="usd">-921000</us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMy0xLTEtMTUxMjY_f157f695-d877-402c-a314-f31a0e02473f"
      unitRef="usd">0</us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtNS0xLTEtMTUxMjk_39bf010e-0a5a-43cc-9135-4c9f8753b3bd"
      unitRef="usd">0</us-gaap:OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMS0xLTEtMA_566991df-e613-4d6f-8ced-a9dccb29b54a"
      unitRef="usd">0</us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtMy0xLTEtMA_f7039268-8ee4-4f37-88f8-45d340357738"
      unitRef="usd">400000</us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzQtNS0xLTEtMA_5be10962-2a29-49ae-8c6a-2a556ee313b5"
      unitRef="usd">2253000</us-gaap:OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax>
    <us-gaap:ComprehensiveIncomeNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtMS0xLTEtMA_f2cbed16-6138-4570-a4c0-c63ce6bc2e2e"
      unitRef="usd">142473000</us-gaap:ComprehensiveIncomeNetOfTax>
    <us-gaap:ComprehensiveIncomeNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtMy0xLTEtMA_f7fde87c-eff4-47c5-b739-3f1ef6ad0246"
      unitRef="usd">12299000</us-gaap:ComprehensiveIncomeNetOfTax>
    <us-gaap:ComprehensiveIncomeNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMDkvZnJhZzpmMTkyMmY3YzQ0N2E0NDI5YWNjNjZjY2E5Y2JjY2I4OC90YWJsZTpmYjg1ZGY2ODRmMTA0ODRkOTgzMDM1NDZlY2IxZTE0MS90YWJsZXJhbmdlOmZiODVkZjY4NGYxMDQ4NGQ5ODMwMzU0NmVjYjFlMTQxXzUtNS0xLTEtMA_c7de54f7-aec2-4037-a017-4aaf7b320e9a"
      unitRef="usd">-3796000</us-gaap:ComprehensiveIncomeNetOfTax>
    <us-gaap:SharesOutstanding
      contextRef="if12b4d59cd2641ccb993432a96845435_I20151231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEtMS0xLTA_f50b5068-09e2-48e2-9e53-c9f7e74bd65c"
      unitRef="shares">19949012</us-gaap:SharesOutstanding>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="if12b4d59cd2641ccb993432a96845435_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTMtMS0xLTA_3f7d7a88-2cb9-44a6-9085-04620e328175"
      unitRef="usd">20000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ia9cbdd5a3f014dbfba8949b4362c8099_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTUtMS0xLTA_45077b4f-fa82-4507-b4e1-6cccae1697c5"
      unitRef="usd">661850000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ied16ee55eeae4367832c19a676fd4c62_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTctMS0xLTA_1df8dd99-b2f0-4c26-aba5-dc0ed3bb69fc"
      unitRef="usd">4903000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i4649e39780384e179cb5b74b4192a407_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTktMS0xLTA_2281cd71-c17a-4f12-98d3-c59e84c860d6"
      unitRef="usd">-429491000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEzLTEtMS0w_c4058d9a-248f-4adb-a9c9-0df3360c7063"
      unitRef="usd">237282000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans
      contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEtMS0xLTA_351591cd-5553-4040-abca-71389d2ff42b"
      unitRef="shares">210626</us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTUtMS0xLTA_271677c6-d2c2-43c4-8c95-798edb669c82"
      unitRef="usd">5416000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEzLTEtMS0w_fdc5efc4-146d-404d-9c9c-21f3d4e2dba4"
      unitRef="usd">5416000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:StockIssuedDuringPeriodSharesAcquisitions
      contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEtMS0xLTA_7e80e84f-ca24-4b43-b034-c49e024c74f9"
      unitRef="shares">790163</us-gaap:StockIssuedDuringPeriodSharesAcquisitions>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTMtMS0xLTA_2612a3fc-4f05-4378-8c86-efdf6881e719"
      unitRef="usd">1000</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTUtMS0xLTA_181cc742-4ac7-4fc1-b8a0-6b400a529953"
      unitRef="usd">77330000</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEzLTEtMS0w_babda09b-4a4b-4a1f-83af-d3098953e055"
      unitRef="usd">77331000</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTUtMS0xLTA_af80daa4-c0c4-4e1f-ab0b-08c4612a7483"
      unitRef="usd">10065000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTEzLTEtMS0w_1d28e6c7-12da-4cf0-8562-795de5149b92"
      unitRef="usd">10065000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTUtMS0xLTA_04612b0b-ceb9-43c3-be74-c0bd8f3a5a56"
      unitRef="usd">18893000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTEzLTEtMS0w_6f188f6e-39ca-43c5-a68d-9e42658e3d81"
      unitRef="usd">18893000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="iac54e5589a0d483d8011205d9b7a1fc9_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEtMS0xLTA_85c20899-2314-4bb4-aabf-7b1571ba0563"
      unitRef="shares">40500</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i1b8cb6a55a9c464abcf88dc5c50e94af_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTUtMS0xLTA_da776cf1-d968-4cd0-b239-931edd8a3135"
      unitRef="usd">3901000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEzLTEtMS0w_17c5d5f8-825d-4014-b7ed-e863b8a5e19c"
      unitRef="usd">3901000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="i1a2836d1fbd04b178ed87e38468a92c5_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTctMS0xLTA_0410ebd1-fabc-4c5b-9a91-b270b67029b3"
      unitRef="usd">-2160000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEzLTEtMS0w_7f1d7a99-dbfe-44e0-80a9-b39bd62b0010"
      unitRef="usd">-2160000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:NetIncomeLoss
      contextRef="i83e610145e1441a4a48edbf5a5efb62b_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTA_66f3a775-f722-4516-8433-5ad4348933e5"
      unitRef="usd">-1636000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEzLTEtMS0w_3a426e17-a028-4a5a-94f5-cd59ca828d60"
      unitRef="usd">-1636000</us-gaap:NetIncomeLoss>
    <us-gaap:SharesOutstanding
      contextRef="i7da8d16c399b44818efd38241c41af9b_I20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEtMS0xLTA_66af52b2-3c58-4f7d-963d-c601e40826f7"
      unitRef="shares">20909301</us-gaap:SharesOutstanding>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i7da8d16c399b44818efd38241c41af9b_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTMtMS0xLTA_ff91d6f2-151a-4723-8df6-cabf33e2b509"
      unitRef="usd">21000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i1119817d95d04c2b84b6f21adc149bc8_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTUtMS0xLTA_136aa39a-8f50-4f32-9aca-89a93c272637"
      unitRef="usd">769653000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="if8adb73be9d64177a10495f9d227b467_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTctMS0xLTA_173e47cd-02e3-4fca-9db6-242d94b073c3"
      unitRef="usd">2743000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i619dc5c14c054866a55684440355f164_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTktMS0xLTA_f6a31ea6-12ff-498f-aba7-b103ce075aff"
      unitRef="usd">-431127000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEzLTEtMS0w_06079120-d599-493a-bc04-1a5a6f1303e9"
      unitRef="usd">341290000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans
      contextRef="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEtMS0xLTA_c6371a1e-4ee7-457c-aaea-89b34df6dde7"
      unitRef="shares">253364</us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTA_f235056e-d3ae-488c-9b34-d3c8faf977c8"
      unitRef="usd">-5558000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEzLTEtMS0w_02131e48-dddc-4a46-b373-f540b40da889"
      unitRef="usd">-5558000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTUtMS0xLTA_e1af285b-7d0c-469a-aa80-d7b1d13e9241"
      unitRef="usd">10704000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTEzLTEtMS0w_3379b0d6-eb65-4edf-953e-804c3de7ec3f"
      unitRef="usd">10704000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTUtMS0xLTA_6d52e68b-9e90-4ff0-866a-5be50abe1ce9"
      unitRef="usd">24916000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTEzLTEtMS0w_d950774d-cc97-40ef-ba40-ddd6657f7e69"
      unitRef="usd">24916000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="i633c7f9aabb54a299dab6a5f6fd22f61_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTEtMS0xLTA_a10a7381-8a05-421c-be75-ff4426f1f86c"
      unitRef="shares">14000</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i8796fb75405f48eaa4d9dd48e6aab816_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTUtMS0xLTA_4043a915-c3b2-4aad-9ffe-ac3f64471fba"
      unitRef="usd">1966000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM0LTEzLTEtMS0w_91d602af-527d-42a2-b327-e2d8c806dc2d"
      unitRef="usd">1966000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="i188efce7ecde4338afd75e87443c6147_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM1LTctMS0xLTA_49723613-b138-4809-924c-04f66e93c9c1"
      unitRef="usd">-257000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM1LTEzLTEtMS0w_ba56df4d-97de-407a-ac06-f56ba8d50802"
      unitRef="usd">-257000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i56fd83bc6dc042639ae1df971a9f4d20_I20170101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTUtMS0xLTA_e9b2b395-58bf-4e4b-ac06-85f8a3ceec47"
      unitRef="usd">456000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="ib96266c9cd9e42b68a5de54609fb51bd_I20170101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTktMS0xLTA_72754b6e-0789-4202-9b59-1055462bc5c1"
      unitRef="usd">17647000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i33d2f89847cf48949592096f2d579f2b_I20170101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM2LTEzLTEtMS0w_2bd288b3-e783-46ea-8b2b-9545e06dffa6"
      unitRef="usd">18103000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:NetIncomeLoss
      contextRef="i1f9437583206454497ad1119bfadd777_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM3LTktMS0xLTA_a2ba8638-5228-4f4b-a7dc-7234c60572c4"
      unitRef="usd">12556000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM3LTEzLTEtMS0w_a94d3ce9-e2c4-4bc3-b800-967c016f5b3a"
      unitRef="usd">12556000</us-gaap:NetIncomeLoss>
    <us-gaap:SharesOutstanding
      contextRef="ic608cbca1fef42b885a41d66ca7b19bd_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTEtMS0xLTA_b246b383-e9a4-401a-8304-6bdda8754eb5"
      unitRef="shares">21148665</us-gaap:SharesOutstanding>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ic608cbca1fef42b885a41d66ca7b19bd_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTMtMS0xLTA_888766a2-93ec-4160-9056-011bec163b31"
      unitRef="usd">21000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i8b39fe8e03bc43f49fbf934d621cb24c_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTUtMS0xLTA_ebdbfefd-ddcf-4b4a-a989-7ccdbff881c5"
      unitRef="usd">798205000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i2513fadb593f42d3b8500a28dadd898f_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTctMS0xLTA_59c114ba-2856-41c5-b623-afef13755bc5"
      unitRef="usd">2486000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i16eca74f8d9c46a28663ad714fd5a4b5_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTktMS0xLTA_099e8a5b-258a-4a2b-b679-5109e3177ff7"
      unitRef="usd">-400924000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzM4LTEzLTEtMS0w_2f9ff596-dfbf-4fca-b823-fad9137c3984"
      unitRef="usd">399788000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans
      contextRef="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTEtMS0xLTEzOTQx_193d4af6-b6b8-44c0-be78-19c66714f243"
      unitRef="shares">399116</us-gaap:StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTUtMS0xLTE0MDQ2_eb43a71b-b6de-4599-8e3d-e68f5e18df50"
      unitRef="usd">16417000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzE5LTEyLTEtMS0xNTE1NA_df92d205-2c05-454f-98d8-ec7aa5def65f"
      unitRef="usd">16417000</us-gaap:StockIssuedDuringPeriodValueShareBasedCompensation>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIwLTUtMS0xLTE0MDU0_9f979f2b-a244-47f5-b9b7-8932cb4119fc"
      unitRef="usd">18859000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIwLTEyLTEtMS0xNTE1Ng_b574f7a9-ac0f-4260-86b9-99c2281457de"
      unitRef="usd">18859000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIxLTUtMS0xLTE0MDU3_62e5d722-7d2a-4ee9-af00-f2fb924b6193"
      unitRef="usd">20846000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIxLTEyLTEtMS0xNTE1OA_ce09c6dc-5889-4623-9d68-fe926e3732af"
      unitRef="usd">20846000</us-gaap:AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="i830785f0aaa348a0a0f236b0dff22c1b_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEtMS0xLTEzOTQ1_3d1e2fdf-4822-4114-9def-08d6d98d8326"
      unitRef="shares">782248</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTUtMS0xLTE0MDYw_c1ebc9c3-b702-48f3-a089-476842ce746c"
      unitRef="usd">127481000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIyLTEyLTEtMS0xNTE1OQ_6151ec63-c396-4b6a-b3e3-d13b588a87d8"
      unitRef="usd">127481000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTctMS0xLTE0MDc4_16b0fba6-ab50-41a7-b8d8-6a54e7956c1f"
      unitRef="usd">73000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTktMS0xLTE0ODc1_df00ec6b-10dc-47c5-b784-e3506db5adcd"
      unitRef="usd"
      xsi:nil="true"/>
    <us-gaap:OtherComprehensiveIncomeLossNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzIzLTEyLTEtMS0xNTE2Mg_008450e2-c9b6-48f1-959e-8238268629ce"
      unitRef="usd">73000</us-gaap:OtherComprehensiveIncomeLossNetOfTax>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i8d92baeda9ac47a986e2a5bd6eacdbf2_I20180101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTctMS0xLTE0MDk4_da406fa7-e103-4fed-bcab-8751cd8bcdd4"
      unitRef="usd">-2662000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i3574527256f745d8bcdc0cb4541c738e_I20180101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTktMS0xLTE0MTA2_4ec19e6c-0ae8-4968-a15b-9795c66482e5"
      unitRef="usd">2662000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i86047298eb4f4ea5ba70e04cad22157a_I20180101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI0LTEyLTEtMS0yMDUwNQ_722d11b3-09f1-4921-aee4-7fa61991bb31"
      unitRef="usd">0</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="ic7fb939626f5447db0b459d9b7bc82d1_I20180101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTktMS0xLTE0MTE2_6f57a0cd-a3f9-44f5-8443-001af3f070ab"
      unitRef="usd">25581000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="i933a7ea4fa9f4cc7bf26d93ee66f026b_I20180101"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI1LTEyLTEtMS0xNTE2NA_61d92f0d-5e72-440e-a9cb-4491e1ead0b1"
      unitRef="usd">25581000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature
      contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTUtMS0xLTIxMzQ3_66503caf-82c4-47be-a415-c04c36c1257f"
      unitRef="usd">-1559000</us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature
      contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI2LTEyLTEtMS0yMTQwOA_2199e0f0-db9a-4d0d-a162-f0d3815c9417"
      unitRef="usd">-1559000</us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes
      contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTUtMS0xLTE4MDM3_8b06a617-7990-4ccb-8ac5-dab23f5b90d8"
      unitRef="usd">3187000</lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes
      contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI3LTEyLTEtMS0yMTQwOQ_f41c4be3-133a-45d5-ac3a-9929c14cfdda"
      unitRef="usd">3187000</lgnd:AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased
      contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTUtMS0xLTIxMzcz_59150ca9-a679-4c43-b846-e474b833734d"
      unitRef="usd">30472000</lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased
      contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEyLTEtMS0yMTQxMg_4cf68707-0007-4701-8b02-f4c4cf866c23"
      unitRef="usd">30472000</lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants
      contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTUtMS0xLTIxMzc2_9601d5b1-46fc-469d-bbb9-71e49dbf1f4e"
      unitRef="usd">1792000</lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants
      contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEyLTEtMS0yMTQxNA_d61b4343-936a-4e73-986b-45ad5e1d7573"
      unitRef="usd">1792000</lgnd:AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions
      contextRef="icc06ba8de9fd4cc286c4f8d482aea08c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTUtMS0xLTIxMzc5_f900c096-6673-4378-8ce3-65852816f6e4"
      unitRef="usd">1680000</lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions
      contextRef="ie022521383864c29a350e9f710b3a989_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEyLTEtMS0yMTQxNQ_39d553c1-8588-4e06-8943-3c53b8f41bbf"
      unitRef="usd">1680000</lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature
      contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTIxMzgy_abbfe3ec-0960-4573-be69-f3362a7b26cd"
      unitRef="usd">-1807000</us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature
      contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEyLTEtMS0yMTQxOA_a1ffddf3-35f4-4ab1-9a74-dd416207558f"
      unitRef="usd">-1807000</us-gaap:AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued
      contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTUtMS0xLTIxMzg1_a100b244-e8a7-4857-9bd1-02594575736f"
      unitRef="usd">97805000</us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued
      contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMyLTEyLTEtMS0yMTQyMA_fdd5041e-0160-465f-9f51-60d39ad52c6a"
      unitRef="usd">97805000</us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions
      contextRef="i88ba66ce182748c58b2c9b3c8afa3209_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTUtMS0xLTIxMzg4_0da46896-6ce5-4c5a-a007-eefcc4d2abc6"
      unitRef="usd">3181000</lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions
      contextRef="iea132a0005bd41ceab4ee94e6d504f4f_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMzLTEyLTEtMS0yMTQyMg_545146ae-b598-4bd3-ad1b-85a069473a2e"
      unitRef="usd">3181000</lgnd:AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment
      contextRef="ie29a9026b9e24d2c8e9eb1ef5b4d1f42_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTctMS0xLTE0MTc5_35199ab6-969a-4e77-897e-7866c411ff41"
      unitRef="usd">-921000</lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI4LTEyLTEtMS0xNTE3MA_14dd086e-5949-4a67-ada1-442026ef859d"
      unitRef="usd">-921000</lgnd:AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalOther
      contextRef="i9dbc8bee8b074582b04f9f0a5317e4ea_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTUtMS0xLTE0NjUz_867106fc-f6f4-45ef-909c-b5e6f421a97c"
      unitRef="usd">183000</us-gaap:AdjustmentsToAdditionalPaidInCapitalOther>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalOther
      contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTE0NjU1_7525e131-188f-46cc-9cfd-a6c55dde0fac"
      unitRef="usd">163000</us-gaap:AdjustmentsToAdditionalPaidInCapitalOther>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalOther
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTEyLTEtMS0xNTE3Mg_a0f37a42-88a1-423d-a5c8-205055fcd1b1"
      unitRef="usd">346000</us-gaap:AdjustmentsToAdditionalPaidInCapitalOther>
    <us-gaap:NetIncomeLoss
      contextRef="iaf38ff04ec764d7f8ddd4c98cc5ad206_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzI5LTktMS0xLTE0MTIx_f0f4b2d2-5440-4d3b-be0d-7462963a792a"
      unitRef="usd">143321000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMwLTEyLTEtMS0xNTE3NA_e91ab0ad-9ec6-49c9-9f1f-d94adf87c336"
      unitRef="usd">143321000</us-gaap:NetIncomeLoss>
    <us-gaap:SharesOutstanding
      contextRef="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEtMS0xLTE1MTg2_103ccf4f-f7ec-475d-9475-ede8c2da62e2"
      unitRef="shares">20765533</us-gaap:SharesOutstanding>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i85f248fcfa3e4c2fb1f2dc777df1ecc2_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTMtMS0xLTE1MTg0_c7b7d59b-3a08-4c36-bb83-d61034ef96a1"
      unitRef="usd">21000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ia9f65f9bd2374512bb8783927196d39a_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTUtMS0xLTE1MTgy_efc9b5be-2422-4bfc-8518-30e81875cd7a"
      unitRef="usd">791114000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="ibcb5b487ee794160bf522b883cfa27c7_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTctMS0xLTE1MTgw_55b6d962-8bb5-4851-828a-18015a1f4e37"
      unitRef="usd">-1024000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="id4a587395c674ab4bf495afb6bd1140b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTktMS0xLTE1MTc4_afc141e7-e2c3-449d-8cef-69d6b7774638"
      unitRef="usd">-229197000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMjEvZnJhZzpiNDBlODg1YmI0MzA0MDVjODdkMGZiMjIyOTc0NjZhNy90YWJsZTo2MjhjNTA2YTI0NjA0MDE0OTJmZmU3MjI3NTA1MGNhNC90YWJsZXJhbmdlOjYyOGM1MDZhMjQ2MDQwMTQ5MmZmZTcyMjc1MDUwY2E0XzMxLTEyLTEtMS0xNTE3Ng_36c7061a-5682-4f0c-be9e-2606d8d80740"
      unitRef="usd">560914000</us-gaap:StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:ProfitLoss
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtMS0xLTEtMA_853d1cbb-19c2-46cd-87e5-b6d97105b037"
      unitRef="usd">143321000</us-gaap:ProfitLoss>
    <us-gaap:ProfitLoss
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtMy0xLTEtMA_a0f790ae-5ae1-49a5-9ee6-c858b16bffd1"
      unitRef="usd">12556000</us-gaap:ProfitLoss>
    <us-gaap:ProfitLoss
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMtNS0xLTEtMA_be26da41-ba50-4304-bb3e-b3102aa21335"
      unitRef="usd">-1636000</us-gaap:ProfitLoss>
    <us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtMS0xLTEtMA_423bc23c-8643-4940-bd18-76016af276c8"
      unitRef="usd">0</us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax>
    <us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtMy0xLTEtMA_03961f27-74b7-4bd5-91c5-1de26ab1782a"
      unitRef="usd">0</us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax>
    <us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQtNS0xLTEtMA_ecbcba9a-0758-416f-b997-dc71e5523627"
      unitRef="usd">731000</us-gaap:DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtMS0xLTEtMA_9d04916a-7c3a-4f5b-8ab4-468b6274c584"
      unitRef="usd">143321000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtMy0xLTEtMA_c126b8ed-4283-4eff-8e59-dfa225c27a37"
      unitRef="usd">12556000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUtNS0xLTEtMA_e0a877be-2d7b-4566-b67b-474372e2991c"
      unitRef="usd">-2367000</us-gaap:IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest>
    <lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtMS0xLTEtMA_1a6370d9-0032-47e8-96ee-e6d9d98a1e93"
      unitRef="usd">-3448000</lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights>
    <lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtMy0xLTEtMA_344a76ea-bcbd-4df2-8b75-b425cb05a741"
      unitRef="usd">-2580000</lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights>
    <lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzgtNS0xLTEtMA_8e27f798-3f1c-4e0c-9a4d-a800a0b497a7"
      unitRef="usd">-3334000</lgnd:NonCashChangeInEstimatedFairValueOfContingentValueRights>
    <us-gaap:RealizedInvestmentGainsLosses
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktMS0xLTEtMA_ee4f41f1-6e48-497a-a675-b63fff0f4e0f"
      unitRef="usd">2611000</us-gaap:RealizedInvestmentGainsLosses>
    <us-gaap:RealizedInvestmentGainsLosses
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktMy0xLTEtMA_7fc51e51-b827-4289-9979-dc207ae49205"
      unitRef="usd">831000</us-gaap:RealizedInvestmentGainsLosses>
    <us-gaap:RealizedInvestmentGainsLosses
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzktNS0xLTEtMA_1dacd750-27e6-49ed-aa70-a5b7d8594e97"
      unitRef="usd">2352000</us-gaap:RealizedInvestmentGainsLosses>
    <us-gaap:DepreciationDepletionAndAmortization
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTEtMS0xLTA_14a14322-4e81-437a-bbc2-76fe6375a83e"
      unitRef="usd">14718000</us-gaap:DepreciationDepletionAndAmortization>
    <us-gaap:DepreciationDepletionAndAmortization
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTMtMS0xLTA_029e3a3f-bd75-40af-8840-f395438eac71"
      unitRef="usd">11714000</us-gaap:DepreciationDepletionAndAmortization>
    <us-gaap:DepreciationDepletionAndAmortization
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzExLTUtMS0xLTA_f6ff2213-6749-448a-bd64-3a28831b7ec3"
      unitRef="usd">11290000</us-gaap:DepreciationDepletionAndAmortization>
    <us-gaap:IncomeLossFromEquityMethodInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTEtMS0xLTA_145c7d91-dadd-4513-8df6-4ec320db6d50"
      unitRef="usd">42346000</us-gaap:IncomeLossFromEquityMethodInvestments>
    <us-gaap:IncomeLossFromEquityMethodInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTMtMS0xLTA_4fc61c55-2dbb-40bd-bea4-73c8391a35a6"
      unitRef="usd">-2048000</us-gaap:IncomeLossFromEquityMethodInvestments>
    <us-gaap:IncomeLossFromEquityMethodInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzEzLTUtMS0xLTA_6ddb0b0c-f2d1-414a-95fa-ad2904619be5"
      unitRef="usd">-23132000</us-gaap:IncomeLossFromEquityMethodInvestments>
    <lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTEtMS0xLTA_0e0b32a4-355c-498c-8333-5e6bef5564f2"
      unitRef="usd">5411000</lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant>
    <lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTMtMS0xLTA_a16c4554-b642-40a8-94a4-09e224ee27e2"
      unitRef="usd">4032000</lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant>
    <lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE0LTUtMS0xLTA_73b8ea51-51fa-454c-b871-2b79ad0c6673"
      unitRef="usd">462000</lgnd:IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant>
    <us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTEtMS0xLTA_96b47567-0776-4669-b22f-c2d6c96f22b4"
      unitRef="usd">5452000</us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments>
    <us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTMtMS0xLTA_7a181494-3b62-41a7-a708-7b0792e14986"
      unitRef="usd">81000</us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments>
    <us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE1LTUtMS0xLTA_dc1aee6c-1224-4827-81fc-8e64b5b65ecb"
      unitRef="usd">-348000</us-gaap:AccretionAmortizationOfDiscountsAndPremiumsInvestments>
    <us-gaap:AmortizationOfFinancingCostsAndDiscounts
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTEtMS0xLTA_56cc12b6-984e-4a9a-b731-b5c2a6d2714e"
      unitRef="usd">43954000</us-gaap:AmortizationOfFinancingCostsAndDiscounts>
    <us-gaap:AmortizationOfFinancingCostsAndDiscounts
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTMtMS0xLTA_6896947d-d432-4e18-933d-b96ba68c35e3"
      unitRef="usd">11619000</us-gaap:AmortizationOfFinancingCostsAndDiscounts>
    <us-gaap:AmortizationOfFinancingCostsAndDiscounts
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE2LTUtMS0xLTA_dd0bb8d7-1c80-40cc-8e95-7039708e9eac"
      unitRef="usd">10925000</us-gaap:AmortizationOfFinancingCostsAndDiscounts>
    <us-gaap:ShareBasedCompensation
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTEtMS0xLTA_5d8d2892-6dc1-41d6-ba4c-8c4c83091513"
      unitRef="usd">20846000</us-gaap:ShareBasedCompensation>
    <us-gaap:ShareBasedCompensation
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTMtMS0xLTA_48b94be0-045f-4872-95ab-7cee48ee5fe6"
      unitRef="usd">24915000</us-gaap:ShareBasedCompensation>
    <us-gaap:ShareBasedCompensation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE4LTUtMS0xLTA_71c0693b-649f-4565-ac24-651ca59fe756"
      unitRef="usd">18893000</us-gaap:ShareBasedCompensation>
    <us-gaap:IncreaseDecreaseInDeferredIncomeTaxes
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTEtMS0xLTA_4aeaf9b8-5a84-47ac-b16e-e2eb23675191"
      unitRef="usd">-29739000</us-gaap:IncreaseDecreaseInDeferredIncomeTaxes>
    <us-gaap:IncreaseDecreaseInDeferredIncomeTaxes
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTMtMS0xLTA_828d9f3f-32a8-4ab2-a5a7-8204fee3f159"
      unitRef="usd">-44518000</us-gaap:IncreaseDecreaseInDeferredIncomeTaxes>
    <us-gaap:IncreaseDecreaseInDeferredIncomeTaxes
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzE5LTUtMS0xLTA_e535e878-a844-4335-afed-46e3cb408357"
      unitRef="usd">-10697000</us-gaap:IncreaseDecreaseInDeferredIncomeTaxes>
    <lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTEtMS0xLTk2Mjg_17331565-46b3-4fba-98f5-3e75b69cb4dd"
      unitRef="usd">32707000</lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement>
    <lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTMtMS0xLTk2MzE_68b40425-8f1e-48ed-a718-81502d71aeda"
      unitRef="usd">0</lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement>
    <lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTUtMS0xLTk2MzQ_e2caf34f-4118-4cc9-8b51-981f6698a66c"
      unitRef="usd">0</lgnd:RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement>
    <lgnd:ChangeInDerivativeAssetAndLiabilityFairValue
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTEtMS0xLTE0OTg4_4e550a09-5998-406b-b8f7-3fc3bb2c403f"
      unitRef="usd">2931000</lgnd:ChangeInDerivativeAssetAndLiabilityFairValue>
    <lgnd:ChangeInDerivativeAssetAndLiabilityFairValue
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTMtMS0xLTE0OTkx_58a8e602-11a9-431f-8e32-43f289c7508a"
      unitRef="usd">0</lgnd:ChangeInDerivativeAssetAndLiabilityFairValue>
    <lgnd:ChangeInDerivativeAssetAndLiabilityFairValue
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIwLTUtMS0xLTE1MDE3_c71cfed1-f97d-4d44-9e91-48eea9bb897d"
      unitRef="usd">0</lgnd:ChangeInDerivativeAssetAndLiabilityFairValue>
    <us-gaap:IncreaseDecreaseInAccountsReceivable
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTEtMS0xLTA_3cd86452-10f5-44c6-8370-0d99a23fbc39"
      unitRef="usd">29544000</us-gaap:IncreaseDecreaseInAccountsReceivable>
    <us-gaap:IncreaseDecreaseInAccountsReceivable
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTMtMS0xLTA_be0e8401-f3a8-4386-a1fc-f070c4b8891a"
      unitRef="usd">8358000</us-gaap:IncreaseDecreaseInAccountsReceivable>
    <us-gaap:IncreaseDecreaseInAccountsReceivable
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIyLTUtMS0xLTA_331f1226-f516-429b-afad-e6f998d24cb6"
      unitRef="usd">8525000</us-gaap:IncreaseDecreaseInAccountsReceivable>
    <us-gaap:IncreaseDecreaseInInventories
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTEtMS0xLTA_67ee2e0c-ec85-4b41-92b4-80e014ccee30"
      unitRef="usd">2559000</us-gaap:IncreaseDecreaseInInventories>
    <us-gaap:IncreaseDecreaseInInventories
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTMtMS0xLTA_5ed788ca-427e-4e98-958f-7411cf6d1d84"
      unitRef="usd">843000</us-gaap:IncreaseDecreaseInInventories>
    <us-gaap:IncreaseDecreaseInInventories
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzIzLTUtMS0xLTA_7b7cc18f-0bee-4b2b-acce-ecab20836a49"
      unitRef="usd">244000</us-gaap:IncreaseDecreaseInInventories>
    <us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTEtMS0xLTA_2d530ae8-59d9-4d89-a97d-38097232d86d"
      unitRef="usd">868000</us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets>
    <us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTMtMS0xLTA_7eac5f12-1909-40f0-bcdf-852f76a845d1"
      unitRef="usd">-402000</us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets>
    <us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI1LTUtMS0xLTA_4e80cc5f-868b-43a7-8d4f-d63f7f28ca1e"
      unitRef="usd">-526000</us-gaap:IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets>
    <us-gaap:IncreaseDecreaseInOtherNoncurrentAssets
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTEtMS0xLTA_a7355ebc-98c9-4698-b9e4-e4d4f7a9ebfd"
      unitRef="usd">-728000</us-gaap:IncreaseDecreaseInOtherNoncurrentAssets>
    <us-gaap:IncreaseDecreaseInOtherNoncurrentAssets
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTMtMS0xLTA_e3eccfd6-2bdb-4e23-8bf0-fb532d562af8"
      unitRef="usd">0</us-gaap:IncreaseDecreaseInOtherNoncurrentAssets>
    <us-gaap:IncreaseDecreaseInOtherNoncurrentAssets
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI2LTUtMS0xLTA_c29d5f63-fb95-49cb-aec7-b64482959fc9"
      unitRef="usd">-183000</us-gaap:IncreaseDecreaseInOtherNoncurrentAssets>
    <us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTEtMS0xLTA_2ac54c47-640a-4710-94f8-64434c6c5928"
      unitRef="usd">-4542000</us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities>
    <us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTMtMS0xLTA_5aefccf6-71f0-461f-98de-480c756d04c0"
      unitRef="usd">-1713000</us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities>
    <us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI3LTUtMS0xLTA_c14e178f-75f0-4515-bfd1-c6726dc8ed24"
      unitRef="usd">-2369000</us-gaap:IncreaseDecreaseInAccountsPayableAndAccruedLiabilities>
    <lgnd:IncreaseDecreaseInContingentLiabilities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTEtMS0xLTk2MTk_d20cd68a-d3e1-494b-b178-a999473af305"
      unitRef="usd">-3842000</lgnd:IncreaseDecreaseInContingentLiabilities>
    <lgnd:IncreaseDecreaseInContingentLiabilities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTMtMS0xLTk2MjI_38eb4298-df4e-4250-9a6f-f8118e4d3bc2"
      unitRef="usd">-4998000</lgnd:IncreaseDecreaseInContingentLiabilities>
    <lgnd:IncreaseDecreaseInContingentLiabilities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMwLTUtMS0xLTk2MjU_917a24f9-cc25-45f7-8a22-35784c8e07e6"
      unitRef="usd">-2268000</lgnd:IncreaseDecreaseInContingentLiabilities>
    <us-gaap:IncreaseDecreaseInContractWithCustomerLiability
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTEtMS0xLTA_2fb4b690-1fd2-4069-81b2-9dced0371e9e"
      unitRef="usd">-1158000</us-gaap:IncreaseDecreaseInContractWithCustomerLiability>
    <us-gaap:IncreaseDecreaseInContractWithCustomerLiability
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTMtMS0xLTA_0195a133-75b6-4043-b5aa-32027b096111"
      unitRef="usd">-926000</us-gaap:IncreaseDecreaseInContractWithCustomerLiability>
    <us-gaap:IncreaseDecreaseInContractWithCustomerLiability
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzI4LTUtMS0xLTA_191bc0e5-9303-46cb-b19e-b6717ddeea1c"
      unitRef="usd">-8000</us-gaap:IncreaseDecreaseInContractWithCustomerLiability>
    <us-gaap:NetCashProvidedByUsedInOperatingActivities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTEtMS0xLTA_9643886d-575d-4fb9-8989-49a91ff09c95"
      unitRef="usd">194059000</us-gaap:NetCashProvidedByUsedInOperatingActivities>
    <us-gaap:NetCashProvidedByUsedInOperatingActivities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTMtMS0xLTA_823dfafe-3593-464f-8b4c-6edabd774193"
      unitRef="usd">88570000</us-gaap:NetCashProvidedByUsedInOperatingActivities>
    <us-gaap:NetCashProvidedByUsedInOperatingActivities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMxLTUtMS0xLTA_9afd5d97-9177-4bd1-a336-9413f01d142d"
      unitRef="usd">60733000</us-gaap:NetCashProvidedByUsedInOperatingActivities>
    <lgnd:PurchaseforCommercialLicenseRights
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTEtMS0xLTA_358442aa-40ee-4cf7-af03-68978e82227e"
      unitRef="usd">10000000</lgnd:PurchaseforCommercialLicenseRights>
    <lgnd:PurchaseforCommercialLicenseRights
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTMtMS0xLTA_4c5beb7c-891a-4943-be27-9f6ababa802e"
      unitRef="usd">0</lgnd:PurchaseforCommercialLicenseRights>
    <lgnd:PurchaseforCommercialLicenseRights
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzMzLTUtMS0xLTA_8541604b-2780-46f5-bd62-bbad18974266"
      unitRef="usd">17695000</lgnd:PurchaseforCommercialLicenseRights>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="ibf1a2a4d3d614da2a9e3262a761010bc_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTEtMS0xLTA_a510a545-bc12-4dd0-b62d-f800117e5a52"
      unitRef="usd">0</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="i346f6d3d9c4c4913bcb746295c506010_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTMtMS0xLTA_07019c96-8dfb-443d-979d-cdcff9334e40"
      unitRef="usd">0</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="i4604c286cb3b4c23b3e7c54016351f4f_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM0LTUtMS0xLTA_1d28e836-b2ec-410f-b052-ce73c3f31aaa"
      unitRef="usd">700000</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="i38e7892ad1fc44c687187391e73e15ad_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTEtMS0xLTA_3c1bc5f9-97ba-417a-807e-d94b80144d80"
      unitRef="usd">0</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="i401746069dc0428bae920f833bd24769_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTMtMS0xLTA_92a588e2-d2ad-403e-8d76-0947ca825241"
      unitRef="usd">0</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireEquityMethodInvestments
      contextRef="i152983bb0da8462dbdf2be5c4ba3bc18_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM2LTUtMS0xLTA_e5c6611c-e211-4966-b1a1-2450010465ce"
      unitRef="usd">1000000</us-gaap:PaymentsToAcquireEquityMethodInvestments>
    <us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTEtMS0xLTA_1ff13a51-2ebb-4381-a1b7-ac67d26a7e92"
      unitRef="usd">5856000</us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired>
    <us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTMtMS0xLTA_5aaae271-5394-4723-a9d1-b66b205165a5"
      unitRef="usd">26653000</us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired>
    <us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM3LTUtMS0xLTA_6d5da46f-2a86-465c-abfa-59fa2affd5e9"
      unitRef="usd">92502000</us-gaap:PaymentsToAcquireBusinessesNetOfCashAcquired>
    <lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTEtMS0xLTA_e2e2747e-3e8c-4e49-a184-d227f441103d"
      unitRef="usd">1000000</lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity>
    <lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTMtMS0xLTA_4024e2df-f891-485e-bc5e-86c547823bdc"
      unitRef="usd">0</lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity>
    <lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM4LTUtMS0xLTA_5bc1b072-4855-4bf7-87d1-ee2aacd41784"
      unitRef="usd">0</lgnd:PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity>
    <us-gaap:PaymentsToAcquirePropertyPlantAndEquipment
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTEtMS0xLTA_03670169-0dc7-4146-b92f-5b5a9acbb059"
      unitRef="usd">887000</us-gaap:PaymentsToAcquirePropertyPlantAndEquipment>
    <us-gaap:PaymentsToAcquirePropertyPlantAndEquipment
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTMtMS0xLTA_dd016c35-ba0e-4c4c-97ee-6322590f5d39"
      unitRef="usd">2156000</us-gaap:PaymentsToAcquirePropertyPlantAndEquipment>
    <us-gaap:PaymentsToAcquirePropertyPlantAndEquipment
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzM5LTUtMS0xLTA_714728f6-9551-46e6-986f-7e5e830d7687"
      unitRef="usd">1850000</us-gaap:PaymentsToAcquirePropertyPlantAndEquipment>
    <us-gaap:PaymentsToAcquireShortTermInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTEtMS0xLTA_5780df80-48be-4dbf-875f-f77ce764961b"
      unitRef="usd">1434255000</us-gaap:PaymentsToAcquireShortTermInvestments>
    <us-gaap:PaymentsToAcquireShortTermInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTMtMS0xLTA_7d7212ed-9b40-48e4-86ea-e37f73bf5613"
      unitRef="usd">254258000</us-gaap:PaymentsToAcquireShortTermInvestments>
    <us-gaap:PaymentsToAcquireShortTermInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQwLTUtMS0xLTA_52f5947c-9309-4083-8a67-b96f265f937a"
      unitRef="usd">164438000</us-gaap:PaymentsToAcquireShortTermInvestments>
    <us-gaap:ProceedsFromSaleOfShortTermInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTEtMS0xLTA_217f6d53-6af8-4d20-948d-56ed2afeabe0"
      unitRef="usd">131942000</us-gaap:ProceedsFromSaleOfShortTermInvestments>
    <us-gaap:ProceedsFromSaleOfShortTermInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTMtMS0xLTA_697d2910-af28-4234-97c9-8668e9cb847a"
      unitRef="usd">86985000</us-gaap:ProceedsFromSaleOfShortTermInvestments>
    <us-gaap:ProceedsFromSaleOfShortTermInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQxLTUtMS0xLTA_6dcd3e08-0f01-4e76-82c6-5994d548bf0c"
      unitRef="usd">24596000</us-gaap:ProceedsFromSaleOfShortTermInvestments>
    <us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTEtMS0xLTA_6074d12d-1fce-41fe-8cb1-bd7d96b7efb7"
      unitRef="usd">892873000</us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments>
    <us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTMtMS0xLTA_792341eb-21e2-4587-9bfe-e5be8229899b"
      unitRef="usd">109649000</us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments>
    <us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQyLTUtMS0xLTA_2297d17d-67ea-400c-b788-497e6b692403"
      unitRef="usd">118874000</us-gaap:ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments>
    <us-gaap:ProceedsFromLicenseFeesReceived
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTEtMS0xLTA_6d09081b-812d-4501-baec-3b73a06e8095"
      unitRef="usd">0</us-gaap:ProceedsFromLicenseFeesReceived>
    <us-gaap:ProceedsFromLicenseFeesReceived
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTMtMS0xLTA_7f8df465-bdbe-49ca-93ac-a432f80ef60c"
      unitRef="usd">7054000</us-gaap:ProceedsFromLicenseFeesReceived>
    <us-gaap:ProceedsFromLicenseFeesReceived
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQzLTUtMS0xLTA_4ddb7ba1-e581-4879-9927-4ed1a91866b9"
      unitRef="usd">0</us-gaap:ProceedsFromLicenseFeesReceived>
    <us-gaap:ProceedsFromCollectionOfNotesReceivable
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTEtMS0xLTA_c34a59e2-0096-4886-a9c3-5843c3d38bbb"
      unitRef="usd">3914000</us-gaap:ProceedsFromCollectionOfNotesReceivable>
    <us-gaap:ProceedsFromCollectionOfNotesReceivable
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTMtMS0xLTA_66731934-53d6-4bc6-a91a-73ee94e668e4"
      unitRef="usd">200000</us-gaap:ProceedsFromCollectionOfNotesReceivable>
    <us-gaap:ProceedsFromCollectionOfNotesReceivable
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ0LTUtMS0xLTA_d8d28787-5e2b-431a-91b0-b1938f57e5ac"
      unitRef="usd">300000</us-gaap:ProceedsFromCollectionOfNotesReceivable>
    <us-gaap:NetCashProvidedByUsedInInvestingActivities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTEtMS0xLTA_749c1d26-7f02-4679-a5a1-67b3baef44e7"
      unitRef="usd">-423269000</us-gaap:NetCashProvidedByUsedInInvestingActivities>
    <us-gaap:NetCashProvidedByUsedInInvestingActivities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTMtMS0xLTA_12a937af-8d79-463d-a4cb-c55d87c204a6"
      unitRef="usd">-79179000</us-gaap:NetCashProvidedByUsedInInvestingActivities>
    <us-gaap:NetCashProvidedByUsedInInvestingActivities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzQ2LTUtMS0xLTA_d03b9555-e8a8-4fd8-836e-6b75bfed734f"
      unitRef="usd">-134415000</us-gaap:NetCashProvidedByUsedInInvestingActivities>
    <us-gaap:RepaymentsOfLongTermDebt
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTEtMS0xLTE0ODg1_c3ad89b2-33fd-4f3f-9807-8a960cace329"
      unitRef="usd">217674000</us-gaap:RepaymentsOfLongTermDebt>
    <us-gaap:RepaymentsOfLongTermDebt
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTMtMS0xLTE0ODg3_8decc827-5d88-4aad-b8c7-2b8770b2c03f"
      unitRef="usd">0</us-gaap:RepaymentsOfLongTermDebt>
    <us-gaap:RepaymentsOfLongTermDebt
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTUtMS0xLTE0ODg5_d03496e6-8e44-46d9-866e-d0d052f865c2"
      unitRef="usd">0</us-gaap:RepaymentsOfLongTermDebt>
    <us-gaap:ProceedsFromNotesPayable
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTEtMS0xLTE0OTA1_81f96b23-931f-4c00-aa3c-973ece0036f8"
      unitRef="usd">750000000</us-gaap:ProceedsFromNotesPayable>
    <us-gaap:ProceedsFromNotesPayable
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTMtMS0xLTE0OTA3_254a019d-364f-4c6a-ad80-2f379ddd875d"
      unitRef="usd">0</us-gaap:ProceedsFromNotesPayable>
    <us-gaap:ProceedsFromNotesPayable
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTUtMS0xLTE0OTA5_cf581d11-34ba-43d5-a4a8-e2eeafb47b85"
      unitRef="usd">0</us-gaap:ProceedsFromNotesPayable>
    <us-gaap:PaymentsOfDebtIssuanceCosts
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTEtMS0xLTE0OTE1_f9254e84-61dd-4aff-9fff-afef3668f3a4"
      unitRef="usd">16900000</us-gaap:PaymentsOfDebtIssuanceCosts>
    <us-gaap:PaymentsOfDebtIssuanceCosts
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTMtMS0xLTE0OTE3_d9f028ad-1ea6-4800-a324-55edfcbd8cf3"
      unitRef="usd">0</us-gaap:PaymentsOfDebtIssuanceCosts>
    <us-gaap:PaymentsOfDebtIssuanceCosts
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTUtMS0xLTE0OTE5_0b401994-8f31-45c6-ab3b-0b3282565beb"
      unitRef="usd">0</us-gaap:PaymentsOfDebtIssuanceCosts>
    <us-gaap:ProceedsFromIssuanceOfWarrants
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTEtMS0xLTE0OTI0_d5829141-f762-4206-80fb-da3bda91d16b"
      unitRef="usd">90000000</us-gaap:ProceedsFromIssuanceOfWarrants>
    <us-gaap:ProceedsFromIssuanceOfWarrants
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTMtMS0xLTE0OTI2_ad90100b-b795-47a5-8d0d-b990f20a2109"
      unitRef="usd">0</us-gaap:ProceedsFromIssuanceOfWarrants>
    <us-gaap:ProceedsFromIssuanceOfWarrants
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTUtMS0xLTE0OTI4_caadccc4-f493-4805-8c4f-b9c0fa19d837"
      unitRef="usd">0</us-gaap:ProceedsFromIssuanceOfWarrants>
    <lgnd:PurchaseOfConvertibleBondHedge
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTEtMS0xLTE0OTMy_db7c6c18-6585-464a-8435-0c37bfcbf372"
      unitRef="usd">140250000</lgnd:PurchaseOfConvertibleBondHedge>
    <lgnd:PurchaseOfConvertibleBondHedge
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTMtMS0xLTE0OTM0_259e4f51-ad2b-4e49-914c-4fbd034bd810"
      unitRef="usd">0</lgnd:PurchaseOfConvertibleBondHedge>
    <lgnd:PurchaseOfConvertibleBondHedge
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTUtMS0xLTE0OTM2_e214a124-8e05-4b41-99c6-1cf26abd10ca"
      unitRef="usd">0</lgnd:PurchaseOfConvertibleBondHedge>
    <us-gaap:ProceedsFromHedgeFinancingActivities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTE0OTQ4_417feb08-a5d9-4f83-89d3-29ccd19e6ac4"
      unitRef="usd">439559000</us-gaap:ProceedsFromHedgeFinancingActivities>
    <us-gaap:ProceedsFromHedgeFinancingActivities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTE0OTUw_f9f0cebd-0d08-421b-9460-abd601047a7e"
      unitRef="usd">0</us-gaap:ProceedsFromHedgeFinancingActivities>
    <us-gaap:ProceedsFromHedgeFinancingActivities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTE0OTUy_b4291aac-020e-489e-8cde-9a309debc979"
      unitRef="usd">0</us-gaap:ProceedsFromHedgeFinancingActivities>
    <us-gaap:PaymentsForHedgeFinancingActivities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTEtMS0xLTE0OTU3_1c038e77-ade8-4a70-8e59-e0eb95c9944b"
      unitRef="usd">439581000</us-gaap:PaymentsForHedgeFinancingActivities>
    <us-gaap:PaymentsForHedgeFinancingActivities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTMtMS0xLTE0OTU5_396a28fc-8417-4537-bbf5-16bd981fe10d"
      unitRef="usd">0</us-gaap:PaymentsForHedgeFinancingActivities>
    <us-gaap:PaymentsForHedgeFinancingActivities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTUtMS0xLTE0OTYx_aed12e35-ed20-4c40-8e02-114be66cf647"
      unitRef="usd">0</us-gaap:PaymentsForHedgeFinancingActivities>
    <us-gaap:ProceedsFromStockOptionsExercised
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTEtMS0xLTA_53749a6c-1bf5-48e7-b8dc-19cd87791269"
      unitRef="usd">20183000</us-gaap:ProceedsFromStockOptionsExercised>
    <us-gaap:ProceedsFromStockOptionsExercised
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTMtMS0xLTA_81d04dbb-a960-45c3-bad6-494e5becd324"
      unitRef="usd">4517000</us-gaap:ProceedsFromStockOptionsExercised>
    <us-gaap:ProceedsFromStockOptionsExercised
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzUzLTUtMS0xLTA_0c5f181f-fe72-48fc-8d1f-b3a95404bf6e"
      unitRef="usd">6415000</us-gaap:ProceedsFromStockOptionsExercised>
    <us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTEtMS0xLTA_979227bb-d35c-4545-b820-26d8139f0e24"
      unitRef="usd">3765000</us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation>
    <us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTMtMS0xLTA_fc44ef7f-3218-4b00-9e5b-145b4baec66a"
      unitRef="usd">10074000</us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation>
    <us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU0LTUtMS0xLTA_ed47af36-5805-448a-9d3f-1d2af6d6e4a0"
      unitRef="usd">999000</us-gaap:PaymentsRelatedToTaxWithholdingForShareBasedCompensation>
    <us-gaap:PaymentsForRepurchaseOfCommonStock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTEtMS0xLTA_740bb4c5-42d4-45a6-b6b5-41436eb837a2"
      unitRef="usd">122868000</us-gaap:PaymentsForRepurchaseOfCommonStock>
    <us-gaap:PaymentsForRepurchaseOfCommonStock
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTMtMS0xLTA_053a4bdd-7320-4ab9-a82c-6d6b1dc53307"
      unitRef="usd">1966000</us-gaap:PaymentsForRepurchaseOfCommonStock>
    <us-gaap:PaymentsForRepurchaseOfCommonStock
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU1LTUtMS0xLTA_afcc24d1-be07-414a-8201-9b1009f4581d"
      unitRef="usd">3901000</us-gaap:PaymentsForRepurchaseOfCommonStock>
    <us-gaap:PaymentsForRepurchaseOfWarrants
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTk2NjU_1dee43ed-1f2b-4fe0-b8cd-f083549f15d8"
      unitRef="usd">30094000</us-gaap:PaymentsForRepurchaseOfWarrants>
    <us-gaap:PaymentsForRepurchaseOfWarrants
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTk2NzQ_b212f0df-9253-4c98-84e6-bf555edd3eb1"
      unitRef="usd">0</us-gaap:PaymentsForRepurchaseOfWarrants>
    <us-gaap:PaymentsForRepurchaseOfWarrants
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTk2Nzc_9ae0e5fc-e142-4281-96dd-c8d6f12cf9d4"
      unitRef="usd">0</us-gaap:PaymentsForRepurchaseOfWarrants>
    <lgnd:PaymentsToContingentValueRightHoldersFinancingActivity
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTEtMS0xLTE3Mjc3_fb30abd5-841e-45ce-bae3-2d8840cba34c"
      unitRef="usd">25000</lgnd:PaymentsToContingentValueRightHoldersFinancingActivity>
    <lgnd:PaymentsToContingentValueRightHoldersFinancingActivity
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTMtMS0xLTE3Mjgw_5137e93c-bfd3-49ba-8ba1-f8e9e0eeb039"
      unitRef="usd">0</lgnd:PaymentsToContingentValueRightHoldersFinancingActivity>
    <lgnd:PaymentsToContingentValueRightHoldersFinancingActivity
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYwLTUtMS0xLTE3Mjgz_74533b1a-5727-4f7e-9de9-417f7c9c0eb2"
      unitRef="usd">6509000</lgnd:PaymentsToContingentValueRightHoldersFinancingActivity>
    <us-gaap:NetCashProvidedByUsedInFinancingActivities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTEtMS0xLTA_6cd8a697-a176-4365-a68e-e042b482b12c"
      unitRef="usd">328585000</us-gaap:NetCashProvidedByUsedInFinancingActivities>
    <us-gaap:NetCashProvidedByUsedInFinancingActivities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTMtMS0xLTA_e0349bc7-d46f-4efc-91ab-4e902dc38124"
      unitRef="usd">-7523000</us-gaap:NetCashProvidedByUsedInFinancingActivities>
    <us-gaap:NetCashProvidedByUsedInFinancingActivities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU2LTUtMS0xLTA_6c361a68-beaa-478d-b4cb-10934a29d397"
      unitRef="usd">-4994000</us-gaap:NetCashProvidedByUsedInFinancingActivities>
    <us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTEtMS0xLTk2ODQ_8a2d6479-e5f7-45dc-a00c-ea01fdcafb8d"
      unitRef="usd">-215000</us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTMtMS0xLTk2ODc_9b7be5ab-7cd7-4147-8d0b-0ffe3aca0d81"
      unitRef="usd">0</us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTUtMS0xLTk2OTY_9608a1dc-ae7c-4c11-aa1a-dd2cba48879c"
      unitRef="usd">0</us-gaap:EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTEtMS0xLTA_4c58645e-134b-4036-93a2-4bd38c7324ed"
      unitRef="usd">99375000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTMtMS0xLTA_b2249821-8691-4c55-a74a-1fd2fd9a18a1"
      unitRef="usd">1868000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU3LTUtMS0xLTA_14a95eae-3acd-4b4d-9a2d-fe4eb992649e"
      unitRef="usd">-78676000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTEtMS0xLTA_4ff23a1e-f8ce-4415-9d4e-fd69f72758d3"
      unitRef="usd">20620000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTMtMS0xLTA_d3af713c-360a-485b-af0e-dbf2a8609e86"
      unitRef="usd">18752000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU4LTUtMS0xLTA_70840fa6-0e6d-4191-a15d-f4013ec78898"
      unitRef="usd">97428000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTEtMS0xLTA_370b1ffb-a863-4982-86df-49e65a0fe258"
      unitRef="usd">119780000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTMtMS0xLTA_762130f8-a0aa-4318-82a2-a00b3eff09eb"
      unitRef="usd">20620000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzU5LTUtMS0xLTA_05871cb5-0443-4cab-b4c7-b6e39041c4cb"
      unitRef="usd">18752000</us-gaap:CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents>
    <us-gaap:InterestPaidNet
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTEtMS0xLTA_8fd32409-eb35-41f5-b55c-6106900228ee"
      unitRef="usd">1513000</us-gaap:InterestPaidNet>
    <us-gaap:InterestPaidNet
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTMtMS0xLTA_54ef32dc-f69b-425e-be54-805f4ffb6b29"
      unitRef="usd">1838000</us-gaap:InterestPaidNet>
    <us-gaap:InterestPaidNet
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYyLTUtMS0xLTA_7475484e-4490-43a2-9f5a-5f29f1c05f8f"
      unitRef="usd">1838000</us-gaap:InterestPaidNet>
    <us-gaap:IncomeTaxesPaid
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTEtMS0xLTA_15e263c8-24cf-4f82-9d1c-a40366a74040"
      unitRef="usd">341000</us-gaap:IncomeTaxesPaid>
    <us-gaap:IncomeTaxesPaid
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTMtMS0xLTA_71315ea7-fcad-47e1-9cca-f2eb3d886c20"
      unitRef="usd">157000</us-gaap:IncomeTaxesPaid>
    <us-gaap:IncomeTaxesPaid
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzYzLTUtMS0xLTA_b8e77169-90d9-4fa7-b9f6-343aed77e62f"
      unitRef="usd">38000</us-gaap:IncomeTaxesPaid>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTEtMS0xLTA_2d03fe5e-4f0d-4883-a917-9228082ffcc2"
      unitRef="usd">0</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTMtMS0xLTA_cb80981b-61cc-4452-a8cc-a433b7038645"
      unitRef="usd">0</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <us-gaap:StockIssuedDuringPeriodValueAcquisitions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY1LTUtMS0xLTA_bff20ba1-e7cf-47c9-bca9-c351839ee3f9"
      unitRef="usd">77331000</us-gaap:StockIssuedDuringPeriodValueAcquisitions>
    <lgnd:EquityReceivedinRepaymentofNoteReceivable
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTEtMS0xLTA_dcf78d33-a28a-4cc6-8711-011506a3e2b1"
      unitRef="usd">0</lgnd:EquityReceivedinRepaymentofNoteReceivable>
    <lgnd:EquityReceivedinRepaymentofNoteReceivable
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTMtMS0xLTA_39725617-60ce-42c0-a4ed-6fa051f491b1"
      unitRef="usd">0</lgnd:EquityReceivedinRepaymentofNoteReceivable>
    <lgnd:EquityReceivedinRepaymentofNoteReceivable
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY2LTUtMS0xLTA_62fdb617-a795-4457-8574-402fbbee63bb"
      unitRef="usd">1200000</lgnd:EquityReceivedinRepaymentofNoteReceivable>
    <lgnd:AccruedInventoryPurchases
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTEtMS0xLTA_90592db0-eb72-480e-9244-3441367dc56f"
      unitRef="usd">2059000</lgnd:AccruedInventoryPurchases>
    <lgnd:AccruedInventoryPurchases
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTMtMS0xLTA_c6187a3a-b577-4c64-937c-29bce27c15c8"
      unitRef="usd">1007000</lgnd:AccruedInventoryPurchases>
    <lgnd:AccruedInventoryPurchases
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY3LTUtMS0xLTA_7b11e7d8-4ddf-46f8-b507-2f81bc55650f"
      unitRef="usd">646000</lgnd:AccruedInventoryPurchases>
    <us-gaap:UnrealizedGainLossOnInvestments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTEtMS0xLTA_17412192-1db5-4da1-8434-c646aee4beb0"
      unitRef="usd">48000</us-gaap:UnrealizedGainLossOnInvestments>
    <us-gaap:UnrealizedGainLossOnInvestments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTMtMS0xLTA_8acdedc9-37be-457b-b0e9-eb8c916bfe8a"
      unitRef="usd">144000</us-gaap:UnrealizedGainLossOnInvestments>
    <us-gaap:UnrealizedGainLossOnInvestments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zMzQvZnJhZzpkMmNkMzAxY2RjODM0MDc5YWFhZDZjMjE5YTkzMTMyMy90YWJsZTo0ODYxYjViODEzNjQ0Mjc2ODJjOTI5MGRlNjExZDQ0MC90YWJsZXJhbmdlOjQ4NjFiNWI4MTM2NDQyNzY4MmM5MjkwZGU2MTFkNDQwXzY4LTUtMS0xLTA_95a99187-bacc-45c6-afec-e6fa2d24090e"
      unitRef="usd">-1109000</us-gaap:UnrealizedGainLossOnInvestments>
    <us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU0_2ea7b012-b03d-4848-9c7d-d5e294a1e9ef">Basis of Presentation and Summary of Significant Accounting Policies&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Business&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Ligand is a biopharmaceutical company with a business model based on developing or acquiring assets which generate royalty, milestone or other passive revenue for the Company using a lean corporate cost structure. We operate in one business segment: development and licensing of biopharmaceutical assets.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Principles of Consolidation&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The accompanying consolidated financial statements include Ligand and its wholly-owned subsidiaries.  All significant intercompany accounts and transactions have been eliminated in consolidation.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Basis of Presentation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our consolidated financial statements have been prepared in accordance with U.S. GAAP and include the accounts of our parent company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Reclassifications&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Certain reclassifications have been made to the previously issued statement of operations to conform with the current period presentation. See detail in &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Accounting Standards Recently Adopted&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; subsection below for further information. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Use of Estimates&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The preparation of consolidated financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes.  Actual results may differ from those estimates.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Concentrations of Business Risk&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Financial instruments that potentially subject to significant concentrations of credit risk consist primarily of cash equivalents and investments. We invest&#160;excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A relatively small number of partners account for a significant percentage of our revenue. Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:52.344624%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner A&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;41&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner B&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;13&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner C&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&amp;lt; 10%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&amp;lt; 10%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We obtain Captisol from two sites at a single supplier, Hovione.&#160;If this supplier were not able to supply the requested amounts of Captisol from each site, and if our safety stocks of material were depleted, we would be unable to continue to derive revenues from the sale of Captisol until we obtained material from an alternative source, which could take a considerable length of time.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Cash Equivalents &amp;amp; Short Term Investments&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Cash equivalents consist of all investments with maturities of&#160;three months or less from the date of acquisition. Short-term investments primarily consist of investments in debt securities that have effective maturities greater than&#160;three&#160;months and less than twelve months from the date of acquisition. We classify our short-term investments as "available-for-sale". Such investments are carried at fair value, with unrealized gains and losses included in the statement of comprehensive income (loss).&#160;We determine the cost of investments based on the specific identification method.&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accounts Receivable&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Trade accounts receivable are recorded at the net invoice value and are not interest bearing. We consider receivables past due based on the contractual payment terms which range from 30 to 90 days. We&#160;reserve specific receivables if collectability is no longer reasonably assured. We re-evaluate such reserves on a regular basis and adjust the reserves as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Inventory&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Inventory, which consists of finished goods, is stated at the lower of cost or market value. We&#160;determine cost using the first-in, first-out method. We analyze our inventory levels periodically and write down inventory to net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements. There were no write downs related to obsolete inventory recorded for the years ended December&#160;31, 2018,&#160;2017 and&#160;2016.  &lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Property and Equipment&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, which generally range from three to ten years, using the straight-line method. Amortization of leasehold improvements is recorded over the shorter of the lease term or estimated useful life of the related asset. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Business Combinations&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition method of accounting for business combinations requires us to use significant estimates and assumptions, including fair value estimates, as of the business combination date and to refine those estimates as necessary during the measurement period (defined as the period, not to exceed one year, in which we may adjust the provisional amounts recognized for a business combination).&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under the acquisition method of accounting, we recognize separately from goodwill the identifiable assets acquired, the liabilities assumed, including contingent consideration and all contractual contingencies, generally at the acquisition date fair value. Contingent purchase consideration to be settled in cash are remeasured to estimated fair value at each reporting period with the change in fair value recorded in other income (expense), net. Costs that we incur to complete the business combination such as investment banking, legal and other professional fees are not considered part of consideration and we charge them to general and administrative expense as they are incurred. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We measure goodwill as of the acquisition date as the excess of consideration transferred, which we also measure at fair value, over the net of the acquisition date amounts of the identifiable assets acquired and liabilities assumed. In addition, IPR&amp;amp;D is capitalized and assessed for impairment annually.  IPR&amp;amp;D is amortized upon product commercialization or upon out-licensing the underlying intellectual property where we have no active involvement in the licensee's development activities. IPR&amp;amp;D is amortized over the estimated life of the commercial product or licensing arrangement.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Should the initial accounting for a business combination be incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date and we record those adjustments to our financial statements in the period of change, if any.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under the acquisition method of accounting for business combinations, if we identify changes to acquired deferred tax asset valuation allowances or liabilities related to uncertain tax positions during the measurement period and they relate to new information obtained about facts and circumstances that existed as of the acquisition date, those changes are considered a&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; measurement period adjustment and we record the offset to goodwill. We record all other changes to deferred tax asset valuation allowances and liabilities related to uncertain tax positions in current period income tax expense. &lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Contingent Liabilities&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with the acquisition of Crystal in October 2017, we may be required to pay up to an additional $10.5 million in purchase consideration upon achievement of certain commercial and development milestones to the Crystal shareholders. &lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with the acquisition of CyDex in January 2011, we recorded a contingent liability for amounts potentially due to holders of the CyDex CVRs and former license holders. The liability is periodically assessed based on events and circumstances related to the underlying milestones, royalties and material sales.  In connection with the acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs for each Metabasis share. The fair values of the CVRs are remeasured at each reporting date through the term of the related agreement. &lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Any change in fair value is recorded in our consolidated statement of operations. For additional information, see &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Note (4), Fair Value Measurement and Note (7), Balance Sheet Account Details&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;.&#x201d; &#160;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Goodwill, Intangible Assets and Other Long-Lived Assets&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if an event occurs indicating the potential for impairment. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than the carrying amount, including goodwill. We operate in one reporting unit. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair value of our reporting unit is less than the carrying amount, then no additional assessment is deemed necessary. Otherwise, we proceed to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with the carrying value, including goodwill. If the carrying amount of the reporting unit exceeds the fair value, the second step of the goodwill impairment test is performed to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. We may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. We performed the annual assessment for goodwill impairment during the fourth quarter of 2018, noting no impairment. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our identifiable intangible assets are typically composed of&#160;acquired core technologies, licensed technologies, customer relationships and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets&#x2019; respective estimated useful lives. We regularly perform reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows, and the pattern of utilization of a particular asset.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Commercial license rights&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Commercial license rights consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:71.893805%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.537463%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, &lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Aziyo &amp;amp; CorMatrix&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Palvella&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Selexis&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Less: accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,838)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(6,772)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total commercial license rights, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;31,460&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,526&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Commercial license rights represent a portfolio of future milestone and royalty payment rights acquired from Selexis in April 2013 and April 2015, CorMatrix in May 2016, and Pavella in December 2018. Individual commercial license rights acquired are accounted for as financial assets further discussed below. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In December 2018, we entered into a development funding and royalties agreement with Palvella.&#160;Pursuant to the agreement, we will receive up to $8.0 million of milestone payments upon the achievement by&#160;Palvella of certain regulatory milestones for PTX-022, a&#160;product candidate being developed to treat pachyonychia congentia, and corporate and financing milestones. In addition to the milestone payments,&#160;Palvella will pay us&#160;tiered royalties from 5.0% to 9.8% based on aggregate annual worldwide net sales of any PTX-022 products, if&#160;approved, subject to Palvella&#x2019;s right to reduce the royalty rates by making payments in certain circumstances. We paid Palvella an upfront payment of $10.0 million, which Palvella is required to use to fund the development of PTX-022. We will not incur any expenses to develop or commercialize PTX-022. Our director,&#160;Todd Davis, is also a director of Palvella, who beneficially owns 2% of Palvella's outstanding equity. Mr. Davis recused himself from all of the board's consideration of the purchase agreement between us and Palvella, including any financial analysis, the terms of the purchase agreement and the vote to approve the purchase agreement and the related transactions.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In May 2017, we entered into a royalty agreement with Aziyo pursuant to which we will receive royalties from certain marketed products that Aziyo acquired from CorMatrix. Pursuant to the agreement, we received $10.0 million in 2017 from Aziyo to buydown the royalty rates on the products CorMatrix sold to Aziyo. The agreement closed on May 31, 2017, in connection with the closing of the asset sale from CorMatrix to Aziyo (the &#x201c;CorMatrix Asset Sale&#x201d;). Per the agreement, we will receive a 5% royalty on the products Aziyo acquired in the CorMatrix Asset Sale, reduced from the original 20% royalty from CorMatrix pursuant to the previously disclosed interest purchase agreement, dated May 3, 2016 (the &#x201c;Original Interest Purchase Agreement&#x201d;) between CorMatrix and us. In addition, Aziyo has agreed to pay us up to $10.0 million of additional milestones tied to cumulative net sales of the products Aziyo acquired in the CorMatrix Asset Sale and to extend the term on these royalties by one year. The royalty agreement will terminate on May 31, 2027. In addition, in May 2017, we entered into an amended and restated interest purchase agreement (the &#x201c;Amended Interest Purchase Agreement&#x201d;) with CorMatrix, which supersedes in its entirety the Original Interest Purchase Agreement. Other than removing the commercial products sold to Aziyo in the CorMatrix Sale, the terms of the Amended Interest Purchase Agreement remain unchanged with respect to the CorMatrix developmental pipeline products, including the royalty rate of 5% on such pipeline products. The Amended Interest Purchase Agreement will terminate 10 years from the date of the first commercial sale of such products. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We account for the Aziyo commercial license right as a financial asset in accordance with ASC 310 and amortize the commercial license right using the&#160;effective interest method whereby we forecast expected cash flows over the term of the arrangement to arrive at an annualized effective interest. The annual effective interest associated with the forecasted cash flows from the royalty agreement with Aziyo as of December 31, 2018 is 26%. Revenue is calculated by multiplying the carrying value of the commercial license right by the effective interest. The payments received in 2018 were accordingly allocated between revenue and the amortization of the commercial license rights.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We elected a prospective approach to account for changes in estimated cash flows and selected a method for determining when an impairment would be recognized and how to measure that impairment. In circumstances where our new estimate of expected cash flows is greater than previously expected, we will update our yield prospectively. While it has not occurred to date, in circumstances where our new estimate of expected cash flows is less than previously expected and below our original estimated yield we will record an impairment. Impairment will be recognized by reducing the financial asset to an amount that represents the present value of our most recent estimate of expected cash flows discounted by the original effective interest rate.&#160; In circumstances where our new estimate of expected cash flows is less than previously expected, but not below our original estimated yield, we will update our yield prospectively.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We account for commercial license rights related to developmental pipeline products on a non-accrual basis. These developmental pipeline products are non-commercialized, non-approved products that require FDA or other regulatory approval, and thus have uncertain cash flows. The developmental pipeline products are on a non-accrual basis as we are not yet able to forecast future cash flows given their pre-commercial stages of development. We will prospectively update the yield model under the effective interest method once the underlying products are commercialized and we can reliably forecast expected cash flows. Income will be calculated by multiplying the carrying value of the commercial license right by the effective interest rate.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Revenue Recognition&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our revenue is generated primarily from royalties on sales of products commercialized by our partners, Captisol material sales, license fees and development, regulatory and sales based milestone payments.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;On January 1, 2018, we adopted ASC 606 which amends the guidance for recognition of revenue from contracts with customers by using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. The results for reporting periods beginning January 1, 2018, are presented in accordance with the new standard, although comparative information has not been restated and continues to be reported under the accounting standards and policies in effect for those periods. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Upon adoption, we recorded a net decrease of&#160;$25.6 million to accumulated deficit due to the cumulative impact of adopting the new standard, with the impact related primarily to the acceleration of royalty revenue, net of related deferred tax impact. See additional information in &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Disaggregation of Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; subsection below. Our accounting policies under the new standard were applied prospectively and are noted below.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Royalties, License Fees and Milestones&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own&#160;under the&#160;contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment.  These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Material Sales&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We recognize revenue when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The timing of revenue recognition, billings and cash collections results in billed accounts receivable, unbilled receivables (contract assets), and customer advances and deposits (contract liabilities) on the Consolidated Balance Sheet.  Except for royalty revenue, we generally receive payment at the point we satisfy our obligation or soon after.  Therefore, we do not generally carry a contract asset or deferred revenue balance.   &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We have revenue sharing arrangements whereby certain revenue proceeds are shared with a third party.  The revenue standard requires an entity to determine whether it is a principal or an agent in these transactions by evaluating the nature of its promise to the customer. We received a $4.6 million milestone payment from a license partner during 2018 of which $3.0 million was paid to a third-party in-licensor. We recorded net revenue of $1.6 million as we believe we are an agent in the transaction. We record amounts due to third-party in-licensors as general and administrative expenses when we are the principal in the transaction. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Disaggregation of Revenue &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under ASC 605, the legacy revenue standard, we would have reported total royalty revenue of $121.0&#160;million&#160;during 2018, disaggregated as follows: Promacta $92.3&#160;million, Kyprolis&#160;$20.9&#160;million, Evomela $5.7&#160;million, and Other $2.1&#160;million. During 2017, royalty revenue continued to be reported in accordance with ASC 605 and was $88.7 million&#160;or disaggregated as follows: Promacta $62.9 million, Kyprolis $16.4 million, Evomela $7.2 million and Other&#160;$2.2 million. During 2016, royalty revenue continued to be reported in accordance with ASC 605 and was $59.4 million&#160;or disaggregated as follows: Promacta $43.0 million, Kyprolis $12.1 million, Evomela $1.4&#160;million and Other $2.9&#160;million.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under ASC 606, royalty revenue was $128.6&#160;million&#160;during 2018 or disaggregated as follows: Promacta $99.3&#160;million, Kyprolis $21.7&#160;million, Evomela $5.7&#160;million and Other $1.9&#160;million.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands), which are not affected by the adoption of ASC 606:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.982456%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:31.490566%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.428931%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.900629%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.428931%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year ended December 31,&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Material Sales&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Captisol&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,123&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,070&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,502&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;License fees, milestones and other&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     License fees&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;78,195&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;13,665&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,570&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Milestones&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,577&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11,093&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16,091&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Other&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,002&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;387&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;93,774&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,347&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,048&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Preclinical Study and Clinical Trial Accruals&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Substantial portions of our preclinical studies and all of our clinical trials have been performed by third-party laboratories, CROs.&#160;We account for a significant portion of&#160;the clinical study costs according to the terms of our contracts with CROs. The terms of the CRO contracts may result in payment flows that do not match the periods over which services are provided to us under such contracts. Our objective is to reflect the appropriate preclinical and clinical trial expenses in our financial statements in the same period as the services occur. As part of the process of preparing our financial statements, we rely on cost information provided by our CROs. We are also required to estimate certain of our expenses resulting from the obligations under the CRO contracts. Accordingly, our preclinical study and clinical trial accrual is dependent upon the timely and accurate reporting of CROs and other third-party vendors. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate as more information becomes available concerning changing circumstances, and conditions or events that may affect such estimates.&#160;No material adjustments to preclinical study and clinical trial accrued expenses have been recognized to date.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Research and Development Expenses&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Research and development expense consists of labor, material, equipment, and allocated facilities costs of our scientific staff who are working pursuant to our collaborative agreements and other research and development projects. Also included in research and development expenses are third-party costs incurred for our research programs including in-licensing costs, CRO costs and costs incurred by other research and development service vendors. We expense these costs as they are incurred. When we make payments for research and development services prior to the services being rendered, we record those amounts as prepaid assets on our consolidated balance sheet and we expense them as the services are provided.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Share-Based Compensation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We incur share-based compensation expense related to restricted stock, ESPP, and stock options.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Restricted stock unit (RSU) and performance stock unit (PSU) are all considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. We recognize share-based compensation expense based on the fair value on a straight-line basis over the requisite service periods of the awards, taking into consideration of forfeitures. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we&#160;reassess the probability of the achievement of such corporate performance goals and any expense change resulting from an adjustment in the estimated shares to be released are treated as a cumulative catch-up in the period of adjustment.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:22.5pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We use the Black-Scholes-Merton option-pricing model to estimate the fair value of stock purchases under ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. We&#160;look to historical and implied volatilities of our stock to determine the expected volatility. The expected term of an award is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that&#160;except for 2007, during which we declared a cash dividend on our common stock of $2.50&#160;per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future.&#160;The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:22.5pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We grant options,&#160;RSUs and PSUs to employees and non-employee directors. Non-employee directors are accounted for as employees. Options and RSUs granted to certain non-employee directors vest one year from the date of grant. Options granted to employees vest 1/8 on the six month anniversary of the date of grant, and 1/48 each month thereafter for forty-two months. RSUs and PSUs granted to employees vest over three years. All option awards generally expire ten years from the date of grant.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Derivatives&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In May 2018, we issued $750.0 million aggregate principal amount of&#160;2023 Notes, bearing cash interest at a rate of 0.75%&#160;per year, payable semi-annually, as further described&#160;in &#x201c;Footnote 6. Convertible Senior Notes.&#x201d; Concurrently with the issuance of the notes, we entered into a series of convertible note hedge&#160;and warrant transactions which in combination are designed to reduce the potential dilution to our stockholders and/or offset the cash&#160;payments we are required to make in excess of the principal amount upon conversion of the notes. The conversion option associated with&#160;the 2023 Notes temporarily met the criteria for an embedded derivative liability which required bifurcation and separate accounting. In&#160;addition, the note hedge and warrants were also temporarily classified as a derivative asset and liability, respectively, on our consolidated balance sheet. As a result of shareholder approval to increase the number of authorized shares of our common stock on June&#160;19, 2018, as discussed in &#x201c;Footnote&#160;6. Convertible Senior Notes,&#x201d; the derivative asset and liabilities were reclassified to additional paid-in&#160;capital. Changes in the fair value of these derivatives prior to being classified in equity were reflected in other expense, net, in our consolidated statements of operations.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the assets and the&#160;inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liabilities associated with the 2023 Notes:&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.698225%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.575148%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:21.076923%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.131361%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.118343%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of May 22, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of June 19, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Common stock price&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$187.09&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$195.91&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, conversion premium and bond hedge&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$248.48&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$248.48&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, warrant&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;315.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;315.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.9%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.8%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Volatility&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dividend yield&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Annual coupon rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Remaining contractual term (in years)&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.98&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with our 2019 Notes, which we issued in August 2014 for $245.0 million aggregate principal amount, on May 22, 2018, we amended it making an irrevocable election to settle the entire note in cash. As a result, we&#160;reclassified from equity to derivative liability the fair value of the conversion premium as of May 22, 2018. Amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the corresponding convertible bond hedge. As a result, we reclassified&#160;from equity to derivative asset the fair value of the bond hedge as of May 22, 2018. Changes in the fair value of these derivatives are&#160;reflected in other expense, net, in our condensed consolidated statements of operations.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the derivative&#160;assets and the inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liability associated with the&#160;2019 Notes:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.812317%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.973021%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.554252%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.973021%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:20.287390%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of May 22, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of December 31, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Common stock price&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$187.09&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$135.70&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, conversion premium and bond hedge&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$75.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$75.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.47%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.60%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Volatility&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dividend yield&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Annual coupon rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Remaining contractual term (in years)&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.25&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.63&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Income Taxes&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We recognize the impact of a tax position in the financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Discontinued Operations&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel. During the year ended December 31, 2016 we recognized a $1.1 million gain due to subsequent changes in certain estimates and liabilities previously recorded.  We recorded a provision for income taxes related to the gain of $0.4 million.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Income (loss) Per Share&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Basic income (loss) per share is calculated by dividing net income by the weighted-average number of common shares outstanding during the period. Diluted income per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares outstanding during the period.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;Potentially dilutive common shares consist of shares issuable under 2019 and 2023 convertible senior notes, stock options and restricted stock. 2019 and 2023 convertible senior notes have a dilutive impact when the average market price of the Company&#x2019;s common stock exceeds the applicable conversion price of the respective notes. It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion. In addition, post May 22, 2018, the 2019 Notes can only be settled in cash and therefore there will be no further impact on income (loss) per share of these notes. Potentially dilutive common shares from stock options and restricted stock are determined using the average share price for each period under the treasury stock method. In addition, the following amounts are assumed to be used to repurchase shares: proceeds from exercise of stock options and the average amount of unrecognized compensation expense for restricted stock.  In loss periods, basic net loss per share and diluted net loss per share are identical since the effect of otherwise dilutive potential common shares is anti-dilutive and therefore excluded&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:61.343109%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares outstanding:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,160&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,032&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,831&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dilutive potential common shares:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Restricted stock&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;72&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;141&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Stock options&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,125&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Warrants associated with 2019 Notes&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,017&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;94&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   2019 Convertible Senior Notes&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;693&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,214&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares used to compute diluted income per share&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,067&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,481&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,831&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Potentially dilutive shares excluded from calculation due to anti-dilutive effect&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,845&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;335&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,544&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Comprehensive Income (Loss)&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Comprehensive income (loss) represents net income (loss) adjusted for the change during the periods presented in unrealized gains and losses on available-for-sale securities, foreign currency translation adjustments, and reclassification adjustments for realized gains or losses included in net income (loss). The unrealized gains or losses are reported on the Consolidated Statements of Comprehensive Income (Loss).&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Foreign Currency Translation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;The British Pound Sterling is the functional currency of Vernalis and the corresponding financial statements have been translated into U.S. Dollars in accordance with ASC 830-30, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;"&gt;Translation of Financial Statements&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;. Assets and liabilities are translated at end-of-period rates while revenues and expenses are translated at average rates in effect during the period in which the activity took place. Equity is translated at historical rates and the resulting cumulative translation adjustments are included as a component of accumulated other comprehensive income (loss).&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accounting Standards Recently Adopted&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Revenue Recognition &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;- In May 2014, the FASB issued new guidance related to revenue recognition, ASU 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10 and 2016-12, which outlines a comprehensive revenue recognition model and supersedes most current revenue recognition guidance. The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services. ASC 606 defines a five-step approach for recognizing revenue, which may require a company to use more judgment and make more estimates than under the current guidance. We adopted this new standard as of January 1, 2018, by using the modified-retrospective method. See &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Royalties&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Licenses Fees and Milestones&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Material Sales&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, and &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Disaggregation of Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; subsections mentioned above for further information. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Financial Instruments&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; - In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10), which requires equity investments (other than those accounted for under the equity method or those that result in consolidation) to be measured at fair value, with changes in fair value recognized in net income. We have strategic investments, including Viking, that fall under this guidance update. We have adopted ASU 2016-01 effective January 1, 2018 as a cumulative-effect adjustment and reclassified $2.7 million unrealized gains on equity investments, net of tax, from accumulated other comprehensive income to accumulated deficit on our consolidated balance sheet. Effective January 1, 2018, our results of operations include the changes in fair value of these financial instruments. S&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;ee &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Item 8. Financial Statements and Supplementary Data&#x2014;Notes to Consolidated Financial Statements&#x2014;Note (2), Investment in Viking&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#x201d; for additional information.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Stock Compensation&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;font-style:italic;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;- In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718), which aims to simplify the accounting for share-based payment transactions, including accounting for income taxes, classification on the statement of cash flows, accounting for forfeitures, and classification of awards as either liabilities or equity. We have adopted this standard effective January 1, 2017. This standard increases the volatility of net income by requiring excess tax benefits from share-based payment arrangements to be classified as discrete items within the provision for income taxes, rather than recognizing excess tax benefits in additional paid-in capital. Upon adoption in the first quarter of 2017, we recorded $17.6 million to accumulated deficit on our consolidated balance sheet, primarily related to unrealized tax benefits associated with share-based compensation. Also, as a result of the adoption of this new standard, we made an accounting policy election to recognize forfeitures as they occur and will no longer estimate expected forfeitures.&#160;In addition, excess income tax benefits from share-based compensation arrangements are classified as cash flows from operations, rather than cash flows from financing activities. We elected to apply the cash flows classification guidance prospectively and have not adjusted prior periods.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Statement of Cash Flows&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; - In August 2016 the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments. The new standard clarifies certain aspects of the statement of cash flows, and aims to reduce diversity in practice regarding how certain transactions are classified in the statement of cash flows. This standard was effective January 1, 2018. We adopted ASU 2016-15 effective January 1, 2018. For the year ended December 31, 2017, we have reclassed&#160;$5.0 million&#160;payments to CVR holders and other contingency payments from investing activities to operating activities. For the year ended December 31, 2016, we have reclassed $8.8 million&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;payments to CVR holders and other contingency payments from investing activities to operating activities and financing activities in amount of $2.3 million and $6.5 million, respectively.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;&#160;In addition, in November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230), Restricted Cash. The standard requires that a statement of cash flows explains the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, restricted cash should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The new guidance is effective for interim and annual periods beginning after December 15, 2017. We adopted this standard retrospectively, effective January 1, 2018 and included restricted cash amount of&#160;$2.6 million, which was included in other current assets in our consolidated balance sheet as of December&#160;31, 2018, in the consolidated statement of cash flows. &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;See additional information in &#x201c;Footnote 7. Balance Sheet Account Details.&#x201d;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;We did not have any restricted cash as of December&#160;31, 2017 and&#160;2016&#160;.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accounting Standards Not Yet Adopted&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Leases&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This standard requires organizations that lease assets to recognize the assets and liabilities created by those leases. The standard also will require disclosures to help investors and other financial statement users better understand the amount, timing, and uncertainty of cash flows arising from leases. The ASU becomes effective for public companies for fiscal years and interim periods within those fiscal years, beginning after December 15, 2018. In 2018, the FASB issued guidance that provides an optional transition method for adoption of this standard, which allows organizations to initially apply the new requirements at the effective date, recognize a cumulative effect adjustment to the opening balance of retained earnings, and continue to apply the legacy guidance in ASC 840, Leases,&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; including its disclosure requirements, in the comparative periods presented. We adopted this standard on January 1, 2019 by applying&#160;this optional transition method. For leases with a term of 12 months or less, we elected to not recognize lease assets and lease liabilities and expense the leases over a straight-line basis for the term of those leases. The adoption of this standards update resulted in no material impact to our balance sheet, statement of operations, equity&#160;or cash flows.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Financial Instruments&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. ASU 2016-13 is effective for us beginning in the first quarter of 2020, with early adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Fair Value Measurement&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement: Disclosure Framework&#x2014; Changes to the Disclosure Requirements for Fair Value Measurement (Topic 820), which modifies the disclosure requirements on fair value measurements. ASU 2018-13 is effective for us beginning in the first quarter of 2020, with earlier adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We do not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on our consolidated financial statements or disclosures.&lt;/span&gt;&lt;/div&gt;</us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock>
    <us-gaap:ConsolidationPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU1_0990d2a4-00a6-48cf-bc9b-7e05d29a49ef">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Principles of Consolidation&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The accompanying consolidated financial statements include Ligand and its wholly-owned subsidiaries.  All significant intercompany accounts and transactions have been eliminated in consolidation.&lt;/span&gt;&lt;/div&gt;</us-gaap:ConsolidationPolicyTextBlock>
    <us-gaap:BasisOfAccountingPolicyPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ5NTA_b465c37e-8df5-41ac-a60c-4ef4918b5b57">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Basis of Presentation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our consolidated financial statements have been prepared in accordance with U.S. GAAP and include the accounts of our parent company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation.&lt;/span&gt;&lt;/div&gt;</us-gaap:BasisOfAccountingPolicyPolicyTextBlock>
    <us-gaap:PriorPeriodReclassificationAdjustmentDescription
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU2_f9ae1702-2f51-4e85-b063-227b6457633c">Reclassifications&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Certain reclassifications have been made to the previously issued statement of operations to conform with the current period presentation. See detail in &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Accounting Standards Recently Adopted&lt;/span&gt; subsection below for further information.</us-gaap:PriorPeriodReclassificationAdjustmentDescription>
    <us-gaap:UseOfEstimates
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU3_d4867b29-20de-4c98-a15b-9180d9e6f99b">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Use of Estimates&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The preparation of consolidated financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes.  Actual results may differ from those estimates.&lt;/span&gt;&lt;/div&gt;</us-gaap:UseOfEstimates>
    <us-gaap:ConcentrationRiskCreditRisk
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjU4_2812d37c-5645-45e6-9b35-af3109c8d3fc">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Concentrations of Business Risk&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Financial instruments that potentially subject to significant concentrations of credit risk consist primarily of cash equivalents and investments. We invest&#160;excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates.&lt;/span&gt;&lt;/div&gt;</us-gaap:ConcentrationRiskCreditRisk>
    <us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDY_0da18747-1e49-4c19-b89b-84393ac28091">Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:52.344624%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.727541%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner A&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;41&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner B&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;13&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Partner C&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&amp;lt; 10%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&amp;lt; 10%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;</us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItMS0xLTEtMA_be4f7d08-1296-4d36-a048-7ccaa736778f"
      unitRef="number">0.40</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i3029e46160e643808e723653c88b6bac_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItMy0xLTEtMA_a01ebe98-1c86-4feb-a4dc-3fe964fdd82b"
      unitRef="number">0.46</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i223dab5f73e347b9b79caa31f48b5d33_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzItNS0xLTEtMA_a9e34c57-47c1-443d-a3ed-f182ebbfe39b"
      unitRef="number">0.41</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="iad54ce0fea834c76ad026f321579313c_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtMS0xLTEtMA_7d504e23-1595-4be7-9a9f-d69f3b05ae76"
      unitRef="number">0.13</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i43cdf2b8a77549fda2334e555da01d30_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtMy0xLTEtMA_c0b5d7cd-f4a3-45c4-b553-d5fad33d01ef"
      unitRef="number">0.19</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i966b40b605c54c23a7a845e4be0cfade_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzMtNS0xLTEtMA_28ec09ec-06f0-4901-84b6-74468cfafdcf"
      unitRef="number">0.14</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i1c82d6eeab5342c98f34c3b8321892fc_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtMS0xLTEtMA_2f37ec08-180e-43fd-bbb4-5a9299bb6f82"
      unitRef="number">0.20</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i2153cdb62e2e4f53a2c6274726b9b87a_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtMy0xLTEtMA_db740372-c375-4992-86e8-ba471cc0368e"
      unitRef="number">10</us-gaap:ConcentrationRiskPercentage1>
    <us-gaap:ConcentrationRiskPercentage1
      contextRef="i151ec7ab8a8b4a41b242da4ab90bcbae_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5YzBlNTkwMWRkMTU0NWE3OTNiMjM1ZGU0NzMzNmE0Ny90YWJsZXJhbmdlOjljMGU1OTAxZGQxNTQ1YTc5M2IyMzVkZTQ3MzM2YTQ3XzQtNS0xLTEtMA_5edec102-ffd5-4b9e-9e99-b4e564d86760"
      unitRef="number">10</us-gaap:ConcentrationRiskPercentage1>
    <lgnd:CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYw_23dfb433-205b-4aca-9589-8353614edfc3">Cash Equivalents &amp;amp; Short Term InvestmentsCash equivalents consist of all investments with maturities of&#160;three months or less from the date of acquisition. Short-term investments primarily consist of investments in debt securities that have effective maturities greater than&#160;three&#160;months and less than twelve months from the date of acquisition. We classify our short-term investments as "available-for-sale". Such investments are carried at fair value, with unrealized gains and losses included in the statement of comprehensive income (loss).&#160;We determine the cost of investments based on the specific identification method.</lgnd:CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock>
    <lgnd:AllowanceForDoubtfulAccountsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYx_316ac9ba-e544-444c-bec7-ed16095b2e57">&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accounts Receivable&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Trade accounts receivable are recorded at the net invoice value and are not interest bearing. We consider receivables past due based on the contractual payment terms which range from 30 to 90 days. We&#160;reserve specific receivables if collectability is no longer reasonably assured. We re-evaluate such reserves on a regular basis and adjust the reserves as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.&lt;/span&gt;&lt;/div&gt;</lgnd:AllowanceForDoubtfulAccountsPolicyTextBlock>
    <us-gaap:InventoryPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjYy_3aa019b6-6286-4921-b109-cb608f900292">InventoryInventory, which consists of finished goods, is stated at the lower of cost or market value. We&#160;determine cost using the first-in, first-out method. We analyze our inventory levels periodically and write down inventory to net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.</us-gaap:InventoryPolicyTextBlock>
    <us-gaap:InventoryWriteDown
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQzMjM_12d3e41e-64dd-4dfd-8f18-88a104bbaafb"
      unitRef="usd">0</us-gaap:InventoryWriteDown>
    <us-gaap:PropertyPlantAndEquipmentPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY0_2b82e4a3-5b97-4e49-84f3-f9c0cb526671">&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Property and Equipment&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, which generally range from three to ten years, using the straight-line method. Amortization of leasehold improvements is recorded over the shorter of the lease term or estimated useful life of the related asset. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.&lt;/span&gt;&lt;/div&gt;</us-gaap:PropertyPlantAndEquipmentPolicyTextBlock>
    <us-gaap:BusinessCombinationsPolicy
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY1_0431d546-913d-4ff9-9847-8ff5f48aa930">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Business Combinations&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition method of accounting for business combinations requires us to use significant estimates and assumptions, including fair value estimates, as of the business combination date and to refine those estimates as necessary during the measurement period (defined as the period, not to exceed one year, in which we may adjust the provisional amounts recognized for a business combination).&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under the acquisition method of accounting, we recognize separately from goodwill the identifiable assets acquired, the liabilities assumed, including contingent consideration and all contractual contingencies, generally at the acquisition date fair value. Contingent purchase consideration to be settled in cash are remeasured to estimated fair value at each reporting period with the change in fair value recorded in other income (expense), net. Costs that we incur to complete the business combination such as investment banking, legal and other professional fees are not considered part of consideration and we charge them to general and administrative expense as they are incurred. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We measure goodwill as of the acquisition date as the excess of consideration transferred, which we also measure at fair value, over the net of the acquisition date amounts of the identifiable assets acquired and liabilities assumed. In addition, IPR&amp;amp;D is capitalized and assessed for impairment annually.  IPR&amp;amp;D is amortized upon product commercialization or upon out-licensing the underlying intellectual property where we have no active involvement in the licensee's development activities. IPR&amp;amp;D is amortized over the estimated life of the commercial product or licensing arrangement.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Should the initial accounting for a business combination be incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date and we record those adjustments to our financial statements in the period of change, if any.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Under the acquisition method of accounting for business combinations, if we identify changes to acquired deferred tax asset valuation allowances or liabilities related to uncertain tax positions during the measurement period and they relate to new information obtained about facts and circumstances that existed as of the acquisition date, those changes are considered a&lt;/span&gt;&lt;/div&gt; measurement period adjustment and we record the offset to goodwill. We record all other changes to deferred tax asset valuation allowances and liabilities related to uncertain tax positions in current period income tax expense.</us-gaap:BusinessCombinationsPolicy>
    <us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgwOTM_25b9e0ec-6908-4d19-9d60-062c09c03e42"
      unitRef="usd">10500000</us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned>
    <lgnd:NumberOfContingentValueRightsIssued
      contextRef="i269cf529b8f542d6b6e89cfb73d21395_I20100131"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzg3NTY_290516fb-145f-4d62-bb99-e3b640512e52"
      unitRef="right">4</lgnd:NumberOfContingentValueRightsIssued>
    <us-gaap:GoodwillAndIntangibleAssetsGoodwillPolicy
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY2_ab83dbbf-4a4c-4a0f-a3e8-816608f85610">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Goodwill, Intangible Assets and Other Long-Lived Assets&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if an event occurs indicating the potential for impairment. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than the carrying amount, including goodwill. We operate in one reporting unit. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair value of our reporting unit is less than the carrying amount, then no additional assessment is deemed necessary. Otherwise, we proceed to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with the carrying value, including goodwill. If the carrying amount of the reporting unit exceeds the fair value, the second step of the goodwill impairment test is performed to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. We may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. We performed the annual assessment for goodwill impairment during the fourth quarter of 2018, noting no impairment. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our identifiable intangible assets are typically composed of&#160;acquired core technologies, licensed technologies, customer relationships and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets&#x2019; respective estimated useful lives. We regularly perform reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows, and the pattern of utilization of a particular asset.&lt;/span&gt;&lt;/div&gt;</us-gaap:GoodwillAndIntangibleAssetsGoodwillPolicy>
    <lgnd:CommercialLicenseRightsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjY3_eba0a98e-90dc-4bbc-8c9b-44f6d3b7a23f">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Commercial license rights&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Commercial license rights consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:71.893805%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.537463%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, &lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Aziyo &amp;amp; CorMatrix&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Palvella&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Selexis&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Less: accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,838)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(6,772)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total commercial license rights, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;31,460&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,526&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Commercial license rights represent a portfolio of future milestone and royalty payment rights acquired from Selexis in April 2013 and April 2015, CorMatrix in May 2016, and Pavella in December 2018. Individual commercial license rights acquired are accounted for as financial assets further discussed below. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In December 2018, we entered into a development funding and royalties agreement with Palvella.&#160;Pursuant to the agreement, we will receive up to $8.0 million of milestone payments upon the achievement by&#160;Palvella of certain regulatory milestones for PTX-022, a&#160;product candidate being developed to treat pachyonychia congentia, and corporate and financing milestones. In addition to the milestone payments,&#160;Palvella will pay us&#160;tiered royalties from 5.0% to 9.8% based on aggregate annual worldwide net sales of any PTX-022 products, if&#160;approved, subject to Palvella&#x2019;s right to reduce the royalty rates by making payments in certain circumstances. We paid Palvella an upfront payment of $10.0 million, which Palvella is required to use to fund the development of PTX-022. We will not incur any expenses to develop or commercialize PTX-022. Our director,&#160;Todd Davis, is also a director of Palvella, who beneficially owns 2% of Palvella's outstanding equity. Mr. Davis recused himself from all of the board's consideration of the purchase agreement between us and Palvella, including any financial analysis, the terms of the purchase agreement and the vote to approve the purchase agreement and the related transactions.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In May 2017, we entered into a royalty agreement with Aziyo pursuant to which we will receive royalties from certain marketed products that Aziyo acquired from CorMatrix. Pursuant to the agreement, we received $10.0 million in 2017 from Aziyo to buydown the royalty rates on the products CorMatrix sold to Aziyo. The agreement closed on May 31, 2017, in connection with the closing of the asset sale from CorMatrix to Aziyo (the &#x201c;CorMatrix Asset Sale&#x201d;). Per the agreement, we will receive a 5% royalty on the products Aziyo acquired in the CorMatrix Asset Sale, reduced from the original 20% royalty from CorMatrix pursuant to the previously disclosed interest purchase agreement, dated May 3, 2016 (the &#x201c;Original Interest Purchase Agreement&#x201d;) between CorMatrix and us. In addition, Aziyo has agreed to pay us up to $10.0 million of additional milestones tied to cumulative net sales of the products Aziyo acquired in the CorMatrix Asset Sale and to extend the term on these royalties by one year. The royalty agreement will terminate on May 31, 2027. In addition, in May 2017, we entered into an amended and restated interest purchase agreement (the &#x201c;Amended Interest Purchase Agreement&#x201d;) with CorMatrix, which supersedes in its entirety the Original Interest Purchase Agreement. Other than removing the commercial products sold to Aziyo in the CorMatrix Sale, the terms of the Amended Interest Purchase Agreement remain unchanged with respect to the CorMatrix developmental pipeline products, including the royalty rate of 5% on such pipeline products. The Amended Interest Purchase Agreement will terminate 10 years from the date of the first commercial sale of such products. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We account for the Aziyo commercial license right as a financial asset in accordance with ASC 310 and amortize the commercial license right using the&#160;effective interest method whereby we forecast expected cash flows over the term of the arrangement to arrive at an annualized effective interest. The annual effective interest associated with the forecasted cash flows from the royalty agreement with Aziyo as of December 31, 2018 is 26%. Revenue is calculated by multiplying the carrying value of the commercial license right by the effective interest. The payments received in 2018 were accordingly allocated between revenue and the amortization of the commercial license rights.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We elected a prospective approach to account for changes in estimated cash flows and selected a method for determining when an impairment would be recognized and how to measure that impairment. In circumstances where our new estimate of expected cash flows is greater than previously expected, we will update our yield prospectively. While it has not occurred to date, in circumstances where our new estimate of expected cash flows is less than previously expected and below our original estimated yield we will record an impairment. Impairment will be recognized by reducing the financial asset to an amount that represents the present value of our most recent estimate of expected cash flows discounted by the original effective interest rate.&#160; In circumstances where our new estimate of expected cash flows is less than previously expected, but not below our original estimated yield, we will update our yield prospectively.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We account for commercial license rights related to developmental pipeline products on a non-accrual basis. These developmental pipeline products are non-commercialized, non-approved products that require FDA or other regulatory approval, and thus have uncertain cash flows. The developmental pipeline products are on a non-accrual basis as we are not yet able to forecast future cash flows given their pre-commercial stages of development. We will prospectively update the yield model under the effective interest method once the underlying products are commercialized and we can reliably forecast expected cash flows. Income will be calculated by multiplying the carrying value of the commercial license right by the effective interest rate.&lt;/span&gt;&lt;/div&gt;</lgnd:CommercialLicenseRightsPolicyTextBlock>
    <lgnd:ScheduleofCommercialLicenseRightsTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDc_0a186723-8f3a-4557-828e-10a58286afc4">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Commercial license rights consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:71.893805%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.537463%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.684366%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, &lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Aziyo &amp;amp; CorMatrix&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17,696&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Palvella&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Selexis&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,602&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,298&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Less: accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,838)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(6,772)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total commercial license rights, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;31,460&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,526&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</lgnd:ScheduleofCommercialLicenseRightsTableTextBlock>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i06d7e832be914ea4927e544711c5f918_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzItMS0xLTEtMA_142d3660-2428-4b48-ac2a-200afaf4b5ce"
      unitRef="usd">17696000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i1714ac5410ad49d586a22807a601a7c8_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzItMy0xLTEtMA_f2189241-5da3-4eba-9c11-a1afc374bff1"
      unitRef="usd">17696000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i1b15f9f5711d44a591a3a36a58b9681a_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMS0xLTEtMjA4MA_cb310c8b-3d43-4f81-96d6-b5a8c4afe86b"
      unitRef="usd">10000000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="if37a84377d584e49a64fd37c3dc17dfb_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMy0xLTEtMjEwMA_c8b6fccc-46d7-4341-a1ce-d92fffae1cf8"
      unitRef="usd">0</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i6a92d032fd254b68a22e68edb0bb484e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMS0xLTEtMA_8b7a32d1-9d17-4ec2-8398-c4ddfc9cb9d4"
      unitRef="usd">8602000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="iea65327226544655a478dc62c46f5a1e_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzMtMy0xLTEtMA_64d097ab-43ef-49d2-b74b-d3b8d605bcb2"
      unitRef="usd">8602000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzQtMS0xLTEtMA_b05e053e-4874-4efa-a3da-2fc43368d0d8"
      unitRef="usd">36298000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzQtMy0xLTEtMA_6300ad5a-dc9a-4683-917d-a41699e670b3"
      unitRef="usd">26298000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzUtMS0xLTEtMA_2f6462f3-3af8-488a-ab91-3f836b05ed09"
      unitRef="usd">4838000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzUtMy0xLTEtMA_bc57fe84-8d1a-4f06-8c12-b78f494b7ae7"
      unitRef="usd">6772000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsNet
      contextRef="id9810b34412c4c1692e219b8fa0e1127_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzYtMS0xLTEtMA_fafa48e0-d741-401e-b115-f76d65019d76"
      unitRef="usd">31460000</us-gaap:FiniteLivedIntangibleAssetsNet>
    <us-gaap:FiniteLivedIntangibleAssetsNet
      contextRef="ib20b4efd3ed74d5391aee43c7b858bd3_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3MDgyZjE2YTgwN2E0ZWJlOWEyOTgzODhkZDMwMGI2Ni90YWJsZXJhbmdlOjcwODJmMTZhODA3YTRlYmU5YTI5ODM4OGRkMzAwYjY2XzYtMy0xLTEtMA_26204dc5-b09c-43d8-8f97-0556966615bb"
      unitRef="usd">19526000</us-gaap:FiniteLivedIntangibleAssetsNet>
    <lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones
      contextRef="ib3eda2c10c4048a7aa0bacbfdfdfbc14_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE2OTg_279ef0b2-e722-41e8-9a18-032b406b931d"
      unitRef="usd">8000000.0</lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones>
    <lgnd:ProductRoyaltyPercentage
      contextRef="i8d095d9391b44d2a86b19f26283e7dc2_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzMg_641707bc-7661-4983-b19c-161135a5fb4d"
      unitRef="number">0.050</lgnd:ProductRoyaltyPercentage>
    <lgnd:ProductRoyaltyPercentage
      contextRef="i9de660fb7aac4b88a7f3df2f717fed6d_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzNQ_d122ea2a-e408-4f19-836e-6e5a3bfd057b"
      unitRef="number">0.098</lgnd:ProductRoyaltyPercentage>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i1b15f9f5711d44a591a3a36a58b9681a_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3MTY_cb310c8b-3d43-4f81-96d6-b5a8c4afe86b"
      unitRef="usd">10000000.0</us-gaap:FiniteLivedIntangibleAssetsGross>
    <lgnd:OwnershipInEntityByDirectorPercentage
      contextRef="i41125f6764344dc486a91d878d152ad5_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3MzU_9681a58c-c1c1-4e62-9971-b7fc346b5eaf"
      unitRef="number">0.02</lgnd:OwnershipInEntityByDirectorPercentage>
    <us-gaap:ProceedsFromRoyaltiesReceived
      contextRef="i4399b7aa92d94af1af9043d8910747e6_D20170101-20171231"
      decimals="-6"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEyNjE5_5edf0775-d46d-4d18-b4db-5a0ff8712926"
      unitRef="usd">10000000.0</us-gaap:ProceedsFromRoyaltiesReceived>
    <lgnd:ProductRoyaltyPercentage
      contextRef="i7fc73450defc41569175c47bffd04a31_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEyOTIy_25e08cd2-f64c-431f-b6ec-b29af8f370bf"
      unitRef="number">0.05</lgnd:ProductRoyaltyPercentage>
    <lgnd:ProductRoyaltyPercentage
      contextRef="i35202cb30da54ce3b43396a39f8f50fd_I20160503"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzMDE5_f9545a76-bffd-4f39-b1c9-3973a2936e07"
      unitRef="number">0.20</lgnd:ProductRoyaltyPercentage>
    <lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones
      contextRef="i7fc73450defc41569175c47bffd04a31_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzMjY0_ec6e38c8-cba3-4b03-8a5e-a0c26685deb9"
      unitRef="usd">10000000.0</lgnd:AdditionalRoyaltiesReceivableUnderSalesbasedMilestones>
    <lgnd:ProductRoyaltyPercentage
      contextRef="i9ba7c91a27af4a8b9cc9746e85a2d4d0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzEzOTcx_71d1ed9a-5345-4114-bc99-1d696a8c6554"
      unitRef="number">0.05</lgnd:ProductRoyaltyPercentage>
    <lgnd:RoyaltyAgreementExpirationPeriod
      contextRef="i7549ea636c7549ba8a48714cecadea82_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE0MDU2_3e49a473-0b79-493f-ade1-f77377142d9e">P10Y</lgnd:RoyaltyAgreementExpirationPeriod>
    <lgnd:ForecastedCashFlowsEffectiveInterestRatePercent
      contextRef="ib11ae4f07611449daceda5854c74bb9c_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE0NTgw_31fdd97a-9e0c-46ef-b8f8-790e7134bca0"
      unitRef="number">0.26</lgnd:ForecastedCashFlowsEffectiveInterestRatePercent>
    <us-gaap:RevenueFromContractWithCustomerPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDg_c356e7b8-8fb5-48cc-80c9-ad092924eaab">&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Revenue Recognition&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our revenue is generated primarily from royalties on sales of products commercialized by our partners, Captisol material sales, license fees and development, regulatory and sales based milestone payments.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;On January 1, 2018, we adopted ASC 606 which amends the guidance for recognition of revenue from contracts with customers by using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. The results for reporting periods beginning January 1, 2018, are presented in accordance with the new standard, although comparative information has not been restated and continues to be reported under the accounting standards and policies in effect for those periods. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Upon adoption, we recorded a net decrease of&#160;$25.6 million to accumulated deficit due to the cumulative impact of adopting the new standard, with the impact related primarily to the acceleration of royalty revenue, net of related deferred tax impact. See additional information in &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Disaggregation of Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; subsection below. Our accounting policies under the new standard were applied prospectively and are noted below.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Royalties, License Fees and Milestones&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own&#160;under the&#160;contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment.  These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Material Sales&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We recognize revenue when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The timing of revenue recognition, billings and cash collections results in billed accounts receivable, unbilled receivables (contract assets), and customer advances and deposits (contract liabilities) on the Consolidated Balance Sheet.  Except for royalty revenue, we generally receive payment at the point we satisfy our obligation or soon after.  Therefore, we do not generally carry a contract asset or deferred revenue balance.   &lt;/span&gt;&lt;/div&gt;We have revenue sharing arrangements whereby certain revenue proceeds are shared with a third party.  The revenue standard requires an entity to determine whether it is a principal or an agent in these transactions by evaluating the nature of its promise to the customer. We received a $4.6 million milestone payment from a license partner during 2018 of which $3.0 million was paid to a third-party in-licensor. We recorded net revenue of $1.6 million as we believe we are an agent in the transaction. We record amounts due to third-party in-licensors as general and administrative expenses when we are the principal in the transaction.</us-gaap:RevenueFromContractWithCustomerPolicyTextBlock>
    <us-gaap:RetainedEarningsAccumulatedDeficit
      contextRef="if72b93facdb542d6b9aa3d2def1abd30_I20180101"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUzMA_2473fd64-a1f1-42cc-b32a-a35a8cd66715"
      unitRef="usd">-25600000</us-gaap:RetainedEarningsAccumulatedDeficit>
    <lgnd:RevenueRecognitionMilestoneMethodMilestonePaymentReceived
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NDE_8d9d0272-82c6-4b7c-9900-5416d0b251a6"
      unitRef="usd">4600000</lgnd:RevenueRecognitionMilestoneMethodMilestonePaymentReceived>
    <lgnd:RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NjA_f072c440-ce51-4acf-a31c-6f8e77a21bbc"
      unitRef="usd">3000000.0</lgnd:RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived>
    <us-gaap:ContractWithCustomerLiabilityRevenueRecognized
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjE3NzE_a8302161-d691-41e3-8192-49debe3bf02b"
      unitRef="usd">1600000</us-gaap:ContractWithCustomerLiabilityRevenueRecognized>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ic47989b86a534d43a5bfc32cf62712d3_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA3NDQ_abc4e551-cd83-4b8b-b85d-f38feae22c6b"
      unitRef="usd">121000000.0</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i60f3b04793a34fca8e8b2fc0fd8651db_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA3Nzk_3d396a58-58bd-4454-8c86-d6378ad05d4c"
      unitRef="usd">92300000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i1c77c0695f9f4bc39202a1ee3b68fe5b_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4MTA_4b3fddd2-956c-4499-8cdf-6893afb6e3ef"
      unitRef="usd">20900000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i15a3fcbde8c3460cb635412e65ed0c9c_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4NDM_f8698ad2-932e-4f22-8d13-46bacc59fb7b"
      unitRef="usd">5700000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i9ae47d774632454eacbfe62e6c31f927_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4Njc_0b4cd19a-3398-44b9-8f63-5d771b972bf9"
      unitRef="usd">2100000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i8689e4eec8504099bab348e57f6a9828_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA4OTE_d38686ae-2b18-420c-a7d0-a861e03b4e38"
      unitRef="usd">88700000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i8a17769dfb7942a285a0d743e736cb10_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5MDg_947e2f93-2c02-459e-b989-cdfd863626af"
      unitRef="usd">62900000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ib8aea3ed0ca949ac8970d2f8fe87f5bf_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5MjU_6c737702-7cdc-411d-b3c8-0dc838c880c4"
      unitRef="usd">16400000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i57170c9749ff46cb9f3837ec92589b71_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NDI_639e57ae-7ba8-4dd1-9330-3a19e5355174"
      unitRef="usd">7200000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ia775da1fbd8a416c8effcacdb92628e3_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NTk_b9c66c14-08cc-48a8-ab06-fb75a505102f"
      unitRef="usd">2200000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i18a21a167bc74581b1487f6c8625553e_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5OTY_291c6807-faab-4806-8001-7eb25322b361"
      unitRef="usd">59400000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i719ef5c241d44dbd96e30c1fa3f49f12_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDA5NzA_f5031fe4-f16d-416d-b46f-ef92e15d74a7"
      unitRef="usd">43000000.0</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i1d061d85ca7a40dba5a324fbc7d0020f_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwMTQ_6aa586e4-217a-4f08-85f8-7f6c7784dcd8"
      unitRef="usd">12100000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i815a29c81959435e8d5fef20b9d28e7a_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwMzI_c87b8e16-c7c6-408a-b0ef-cbc7b8387c13"
      unitRef="usd">1400000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i26c94f297be24d6a90b411c3a92ab896_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwNTk_82ae6ffd-3ec4-454d-a06d-bcff8e1d874c"
      unitRef="usd">2900000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i4e7fa4a70a214ac3980148658f7bffbd_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExNzY_6e7c9a7a-2518-4c15-9bde-de44a9658b7b"
      unitRef="usd">128600000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i07237780f1df476eab12d1e41646c600_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDEwODg_119e0ad2-11d1-4800-ab78-cb634fded25b"
      unitRef="usd">99300000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ia7034272bd6c43f6b5e9790c96dd349d_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExMTI_59d6c466-290e-4d98-8b32-b1e5d76368c4"
      unitRef="usd">21700000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ifeacc0dfa0ef409c9bf44db88ebbe700_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExMzY_8c12b825-ac4f-45e3-bf31-cab2639521f2"
      unitRef="usd">5700000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i305991a6fef5462c822324d86c4372dd_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNDExNjA_73ceffa1-a665-4e75-abf1-2dcc9048d074"
      unitRef="usd">1900000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:DisaggregationOfRevenueTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NTA_4125f2fa-be75-4cdf-ab12-a8181f26b1ae">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands), which are not affected by the adoption of ASC 606:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.982456%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:31.490566%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.428931%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.900629%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.428931%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.383648%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year ended December 31,&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Material Sales&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Captisol&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,123&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,070&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,502&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;License fees, milestones and other&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     License fees&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;78,195&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;13,665&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,570&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Milestones&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,577&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11,093&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16,091&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Other&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,002&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;387&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;93,774&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,347&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,048&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:DisaggregationOfRevenueTableTextBlock>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ia1f955a4fe44431a8910511b6196f6c3_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtMi0xLTEtMzkzNw_51866514-d048-42c7-bae9-6233192016f2"
      unitRef="usd">29123000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i7a778ad2accc44ee9ab71cdfe20dabb6_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtNC0xLTEtMzkyMw_3aabff12-babf-4e5b-8040-cf4fb940a735"
      unitRef="usd">22070000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i98f80b1c49824a5fbccc53c78e11b74e_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzMtNi0xLTEtMzkyOA_6d308fc8-b491-440b-ae2f-a38a6da28eed"
      unitRef="usd">22502000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i1d2a7464c56c40d39f92de328c3dd17e_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtMi0xLTEtMzk0NA_639b1cbe-7ac0-41c3-ad8d-94fc2bd21b52"
      unitRef="usd">78195000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i2534882e69ce43a6b613a1d083bfb3bd_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtNC0xLTEtMzkzMQ_8c0de5ec-79a5-473e-9047-d8745a738bb4"
      unitRef="usd">13665000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i4f60f855c1a14d8ab2bd47c786fc554e_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzUtNi0xLTEtMzkzNA_d38c22fc-0788-42e4-bff7-3f1e26e793fe"
      unitRef="usd">10570000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ie60c64b8008d42408987815303a30765_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtMi0xLTEtMzk0NA_eb911a56-aa82-4dc3-b60b-a18327e5b5d5"
      unitRef="usd">6577000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ia6e4af4ff3e0471097da34093a9ca62b_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtNC0xLTEtMzkzMQ_85628ef0-9d0f-443a-bde9-c8a305da068b"
      unitRef="usd">11093000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="icd3fbafcbe94483b8d0196d9163c3fdb_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzYtNi0xLTEtMzk0OA_d7a09a98-b066-49b1-a911-9fe2e0453a6a"
      unitRef="usd">16091000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i0313533c50f047899180474a41ba7930_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctMi0xLTEtMzk0NA_0155c0d1-7a9b-4943-94c3-09bec9f8bcd0"
      unitRef="usd">9002000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i39dc95b331cd4a8faf8361f5540b8486_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctNC0xLTEtMzkzMQ_f4df443c-de3f-4c49-99ae-49f47bdbc992"
      unitRef="usd">5589000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ic8aa5f1c584f420aa7237defcce7252f_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzctNi0xLTEtMzk0OA_56cca852-da5c-4e84-9b40-eb631ad9cb73"
      unitRef="usd">387000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i127f9bf804354e6a9832dc41408d4082_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtMi0xLTEtMzk1Nw_f12344dc-acc7-47ad-8772-3275fb3b7195"
      unitRef="usd">93774000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i6b10f836e8cd431c965ac786dda94993_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtNC0xLTEtNzc4OA_cea28d8a-9d9f-4025-9d91-d0fac8fab0a1"
      unitRef="usd">30347000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i827aa32e6966431f90040e4f23139fce_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTpkNTcyOTg3NTU5ZDM0ZTEyOWMwMjZjOTdhM2RkYmQ4ZC90YWJsZXJhbmdlOmQ1NzI5ODc1NTlkMzRlMTI5YzAyNmM5N2EzZGRiZDhkXzgtNi0xLTEtMzk2MA_4987d579-bcd7-4beb-be63-2e190642db02"
      unitRef="usd">27048000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <lgnd:PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcw_c3c6c825-821c-4cad-8f04-9fcea18ea6d4">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Preclinical Study and Clinical Trial Accruals&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Substantial portions of our preclinical studies and all of our clinical trials have been performed by third-party laboratories, CROs.&#160;We account for a significant portion of&#160;the clinical study costs according to the terms of our contracts with CROs. The terms of the CRO contracts may result in payment flows that do not match the periods over which services are provided to us under such contracts. Our objective is to reflect the appropriate preclinical and clinical trial expenses in our financial statements in the same period as the services occur. As part of the process of preparing our financial statements, we rely on cost information provided by our CROs. We are also required to estimate certain of our expenses resulting from the obligations under the CRO contracts. Accordingly, our preclinical study and clinical trial accrual is dependent upon the timely and accurate reporting of CROs and other third-party vendors. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate as more information becomes available concerning changing circumstances, and conditions or events that may affect such estimates.&#160;No material adjustments to preclinical study and clinical trial accrued expenses have been recognized to date.&lt;/span&gt;&lt;/div&gt;</lgnd:PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock>
    <us-gaap:ResearchAndDevelopmentExpensePolicy
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcx_98cacc4d-f1fd-4161-9ac4-185d3052479b">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Research and Development Expenses&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Research and development expense consists of labor, material, equipment, and allocated facilities costs of our scientific staff who are working pursuant to our collaborative agreements and other research and development projects. Also included in research and development expenses are third-party costs incurred for our research programs including in-licensing costs, CRO costs and costs incurred by other research and development service vendors. We expense these costs as they are incurred. When we make payments for research and development services prior to the services being rendered, we record those amounts as prepaid assets on our consolidated balance sheet and we expense them as the services are provided.&lt;/span&gt;&lt;/div&gt;</us-gaap:ResearchAndDevelopmentExpensePolicy>
    <us-gaap:ShareBasedCompensationOptionAndIncentivePlansPolicy
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzY1OTcwNjk4NzI3ODA_a479ba2f-9a45-4ee3-a730-1b0d9977929b">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Share-Based Compensation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We incur share-based compensation expense related to restricted stock, ESPP, and stock options.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Restricted stock unit (RSU) and performance stock unit (PSU) are all considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. We recognize share-based compensation expense based on the fair value on a straight-line basis over the requisite service periods of the awards, taking into consideration of forfeitures. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we&#160;reassess the probability of the achievement of such corporate performance goals and any expense change resulting from an adjustment in the estimated shares to be released are treated as a cumulative catch-up in the period of adjustment.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:22.5pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We use the Black-Scholes-Merton option-pricing model to estimate the fair value of stock purchases under ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. We&#160;look to historical and implied volatilities of our stock to determine the expected volatility. The expected term of an award is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that&#160;except for 2007, during which we declared a cash dividend on our common stock of $2.50&#160;per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future.&#160;The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:22.5pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We grant options,&#160;RSUs and PSUs to employees and non-employee directors. Non-employee directors are accounted for as employees. Options and RSUs granted to certain non-employee directors vest one year from the date of grant. Options granted to employees vest 1/8 on the six month anniversary of the date of grant, and 1/48 each month thereafter for forty-two months. RSUs and PSUs granted to employees vest over three years. All option awards generally expire ten years from the date of grant.&lt;/span&gt;&lt;/div&gt;Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests.</us-gaap:ShareBasedCompensationOptionAndIncentivePlansPolicy>
    <us-gaap:EquitySecuritiesFvNiMeasurementInput
      contextRef="i6a68a109b1a44264b74ff24de2d81961_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI2MDkx_d49e89df-cb32-4a1a-9e87-17aef8c45b1b"
      unitRef="number">0</us-gaap:EquitySecuritiesFvNiMeasurementInput>
    <us-gaap:CommonStockDividendsPerShareDeclared
      contextRef="i4a0ce876e13c454b96f993d4d4ad5af9_D20070101-20071231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjcwNzE_e3a41123-4caf-4fea-92d4-be00ccf72561"
      unitRef="usdPerShare">2.50</us-gaap:CommonStockDividendsPerShareDeclared>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod
      contextRef="i6b500c2fbd5346e2a6d6116c3b290d3c_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI2ODky_3d6bd067-acd9-4c90-9505-62161fdf8289">P10Y</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="i8e9409e1ae334493b8b799a5136ed402_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyMw_ed256b4e-0db6-40d5-937b-73f4ff57f9f4"
      unitRef="usd">750000000.0</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentInterestRateStatedPercentage
      contextRef="i8e9409e1ae334493b8b799a5136ed402_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyNw_a85ec64c-aadb-4b68-a7b0-32073a55ad66"
      unitRef="number">0.0075</us-gaap:DebtInstrumentInterestRateStatedPercentage>
    <us-gaap:ScheduleOfDerivativeInstrumentsTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NTE_2b103abc-727d-4ea1-a68f-efe19c1c0781">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the assets and the&#160;inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liabilities associated with the 2023 Notes:&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.698225%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.575148%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:21.076923%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.131361%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.118343%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of May 22, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of June 19, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Common stock price&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$187.09&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$195.91&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, conversion premium and bond hedge&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$248.48&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$248.48&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, warrant&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;315.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;315.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.9%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.8%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Volatility&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dividend yield&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Annual coupon rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Remaining contractual term (in years)&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.98&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with our 2019 Notes, which we issued in August 2014 for $245.0 million aggregate principal amount, on May 22, 2018, we amended it making an irrevocable election to settle the entire note in cash. As a result, we&#160;reclassified from equity to derivative liability the fair value of the conversion premium as of May 22, 2018. Amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the corresponding convertible bond hedge. As a result, we reclassified&#160;from equity to derivative asset the fair value of the bond hedge as of May 22, 2018. Changes in the fair value of these derivatives are&#160;reflected in other expense, net, in our condensed consolidated statements of operations.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the derivative&#160;assets and the inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liability associated with the&#160;2019 Notes:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.812317%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.973021%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:19.554252%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.973021%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:20.287390%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of May 22, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;As of December 31, 2018&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Common stock price&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$187.09&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$135.70&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercise price, conversion premium and bond hedge&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$75.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$75.05&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.47%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.60%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Volatility&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30%-35%&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dividend yield&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Annual coupon rate&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.75%&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Remaining contractual term (in years)&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.25&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.63&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfDerivativeInstrumentsTextBlock>
    <us-gaap:SharePrice
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzEtMi0xLTEtNzgwOQ_6787366e-c524-4a7d-a6b8-a49301a63eff"
      unitRef="usdPerShare">187.09</us-gaap:SharePrice>
    <us-gaap:SharePrice
      contextRef="id59bcc52dcb84716a983b5657976b3d8_I20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzEtNC0xLTEtNzgzNQ_4aee4833-0dc8-425e-a370-82bb82565dc2"
      unitRef="usdPerShare">195.91</us-gaap:SharePrice>
    <lgnd:ExercisePriceofConvertibleBondHedge
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzItMi0xLTEtNzgxMQ_11dfa716-4555-45fd-a343-4f13c88693c8"
      unitRef="usdPerShare">248.48</lgnd:ExercisePriceofConvertibleBondHedge>
    <lgnd:ExercisePriceofConvertibleBondHedge
      contextRef="id59bcc52dcb84716a983b5657976b3d8_I20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzItNC0xLTEtNzgzMw_32c69030-9cc3-424e-a3f0-8572c9aee39b"
      unitRef="usdPerShare">248.48</lgnd:ExercisePriceofConvertibleBondHedge>
    <invest:InvestmentWarrantsExercisePrice
      contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzMtMi0xLTEtNzgxMw_847971d6-8bb0-45ef-85df-87a5a5951a6d"
      unitRef="usdPerShare">315.38</invest:InvestmentWarrantsExercisePrice>
    <invest:InvestmentWarrantsExercisePrice
      contextRef="i07c0e2d53ab44177baafdb7c634d98df_D20180619-20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzMtNC0xLTEtNzgzMQ_cd6e6a4a-7a20-41cb-8613-8df3f3c15dd7"
      unitRef="usdPerShare">315.38</invest:InvestmentWarrantsExercisePrice>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="ie0bd90f3b36c43ff967e6b073bb482f5_I20180522"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzQtMi0xLTEtNzgxNQ_311bd50f-c253-43de-a5da-05902c169ac5"
      unitRef="number">0.029</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="ie646486a057a4a24abd210fcf89ec5ac_I20180619"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzQtNC0xLTEtNzgyOQ_786f82a9-5274-47e4-844d-e9ceabfb6ad0"
      unitRef="number">0.028</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i5528cc9246cd4cbf9e55a7081d960d09_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzYtMi0xLTEtNzgxNw_24c1c84c-df46-4f50-8e49-fc42682d4705"
      unitRef="number">0</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i36c8e54238ca4f048bcdea0102a51a07_I20180619"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzYtNC0xLTEtNzgyMw_9d7fe06f-9175-4a20-ac2d-c5918b3c3d9d"
      unitRef="number">0</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="ie6b95d8edafe43388cdc0a5d870ca950_I20180522"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzctMi0xLTEtNzgxOQ_b58a0d54-adcc-4ec7-b0b3-ce281907be4e"
      unitRef="number">0.0075</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="icf8c60c7fdb64e0ba05e9b87d3d24fd7_I20180619"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzctNC0xLTEtNzgyNQ_1588524e-2f06-42c7-ac2d-482407e96001"
      unitRef="number">0.0075</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i68d6900fd0a8486397608f93ae2f2950_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzgtMi0xLTEtNzgyMQ_9dce3d22-1051-447c-a16a-43d652e13503"
      unitRef="number">5.05</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i1ab3629dd4a84f25af6a6ed28fff01a6_I20180619"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo5ZmU0MzZjNThiZTU0NjAyYjIzMDhhMGQ1YmMyY2I1My90YWJsZXJhbmdlOjlmZTQzNmM1OGJlNTQ2MDJiMjMwOGEwZDViYzJjYjUzXzgtNC0xLTEtNzgyNw_fbc526e2-c272-470a-bcb3-85a4ed8abe50"
      unitRef="number">4.98</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNjczOTU_530ba52d-a39f-44f7-8e97-c611a0808ec0"
      unitRef="usd">245000000.0</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:SharePrice
      contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzEtMi0xLTEtNzg1MQ_240d3887-b637-4b5e-b855-3a83f0082ffc"
      unitRef="usdPerShare">187.09</us-gaap:SharePrice>
    <us-gaap:SharePrice
      contextRef="i788db1d002a24118902ba114a1c848a8_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzEtNC0xLTEtNzg1Mw_5d950e30-ec71-4ec5-850d-8c89fe3a2f84"
      unitRef="usdPerShare">135.70</us-gaap:SharePrice>
    <lgnd:ExercisePriceofConvertibleBondHedge
      contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzItMi0xLTEtNzg0OQ_da07c5e9-0ee4-4a53-9f83-4d219623d03f"
      unitRef="usdPerShare">75.05</lgnd:ExercisePriceofConvertibleBondHedge>
    <lgnd:ExercisePriceofConvertibleBondHedge
      contextRef="i788db1d002a24118902ba114a1c848a8_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzItNC0xLTEtNzg1MQ_f6402278-348e-4ca0-a7ca-740e722608a6"
      unitRef="usdPerShare">75.05</lgnd:ExercisePriceofConvertibleBondHedge>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i94bfc7a6eb3c4e7f8de61d82318efc87_I20180522"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzMtMi0xLTEtNzg0OQ_4e1e11a8-ae21-449a-8ad9-d82032fcbb19"
      unitRef="number">0.0247</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i4f4b2d2a5e634e08a972694ba181cfbf_I20181231"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzMtNC0xLTEtNzg0Nw_9cc9be84-79e4-4a94-9634-44ada0b39037"
      unitRef="number">0.0260</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="if82e065acc144b048906db168419d424_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzUtMi0xLTEtNzg0NQ_2db71ad7-7c65-4448-a1d2-6c21fad30847"
      unitRef="number">0</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="ibf06eb88f9114519b8566ae3991390c1_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzUtNC0xLTEtNzg0NQ_2477e7d1-870f-482f-bad8-a2fe29683b7e"
      unitRef="number">0</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i05c9c59e0a404b2384aa8481bfe4e0f8_I20180522"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzYtMi0xLTEtNzg0Mg_bdb5d606-76ac-4fc8-a55f-549a36ccc196"
      unitRef="number">0.0075</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="idc51ddeb3e934105a34f1deb7f263b29_I20181231"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzYtNC0xLTEtNzgzOQ_01946e43-b5d5-440f-9010-1574d125ea3b"
      unitRef="number">0.0075</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="iab43107ea2de411d8ec195b05082d875_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzctMi0xLTEtNzgzNw_e749ecee-3b34-4588-8c52-286dd8a2b9d6"
      unitRef="number">1.25</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:DerivativeLiabilityMeasurementInput
      contextRef="i7f9f95d1537a49879879507d3c5b2ba7_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZToyZWY3MzIxY2M2OWI0ODA0ODdjNzg4NWFlNmM2OGQ5Zi90YWJsZXJhbmdlOjJlZjczMjFjYzY5YjQ4MDQ4N2M3ODg1YWU2YzY4ZDlmXzctNC0xLTEtNzgzOQ_d3ff659e-00de-47b3-94a8-10d0a5ecb9df"
      unitRef="number">0.63</us-gaap:DerivativeLiabilityMeasurementInput>
    <us-gaap:IncomeTaxPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjcz_064c9a7e-f1ba-4269-b288-3877602cdf52">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Income Taxes&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We recognize the impact of a tax position in the financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.&lt;/span&gt;&lt;/div&gt;</us-gaap:IncomeTaxPolicyTextBlock>
    <us-gaap:DiscontinuedOperationsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjc0_7e7a12b8-f9eb-40ae-a7b4-245df66d3862">Discontinued OperationsIn 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel.</us-gaap:DiscontinuedOperationsPolicyTextBlock>
    <us-gaap:GainLossOnSaleOfBusiness
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI5MzQy_80892b82-d288-47b9-b35c-384538d7f9f7"
      unitRef="usd">1100000</us-gaap:GainLossOnSaleOfBusiness>
    <us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI5NDk5_8766abff-fe5e-4b1c-aa7b-49a5602a5edc"
      unitRef="usd">400000</us-gaap:DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation>
    <us-gaap:EarningsPerSharePolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDU_e71a4a2d-3ffb-479f-80f1-5a2405392162">&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Income (loss) Per Share&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Basic income (loss) per share is calculated by dividing net income by the weighted-average number of common shares outstanding during the period. Diluted income per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares outstanding during the period.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;Potentially dilutive common shares consist of shares issuable under 2019 and 2023 convertible senior notes, stock options and restricted stock. 2019 and 2023 convertible senior notes have a dilutive impact when the average market price of the Company&#x2019;s common stock exceeds the applicable conversion price of the respective notes. It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion. In addition, post May 22, 2018, the 2019 Notes can only be settled in cash and therefore there will be no further impact on income (loss) per share of these notes. Potentially dilutive common shares from stock options and restricted stock are determined using the average share price for each period under the treasury stock method. In addition, the following amounts are assumed to be used to repurchase shares: proceeds from exercise of stock options and the average amount of unrecognized compensation expense for restricted stock.  In loss periods, basic net loss per share and diluted net loss per share are identical since the effect of otherwise dilutive potential common shares is anti-dilutive and therefore excluded&lt;/span&gt;&lt;/div&gt;</us-gaap:EarningsPerSharePolicyTextBlock>
    <us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzgyNDYzMzczMTQ0NDk_dfdfd003-3af6-4288-b34d-0f0eafdf53a1">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:61.343109%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.730205%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares outstanding:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,160&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,032&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,831&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Dilutive potential common shares:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Restricted stock&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;72&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;141&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Stock options&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,125&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   Warrants associated with 2019 Notes&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,017&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;94&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;   2019 Convertible Senior Notes&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;693&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,214&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares used to compute diluted income per share&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,067&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,481&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,831&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Potentially dilutive shares excluded from calculation due to anti-dilutive effect&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,845&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;335&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,544&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItMS0xLTEtMA_eacb2c3a-f19d-47f9-bbf1-14763368636a"
      unitRef="shares">21160000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItMy0xLTEtMA_66294cc1-4c08-4116-9987-df230a8839a8"
      unitRef="shares">21032000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzItNS0xLTEtMA_8e861108-7ca1-4c2c-9ad7-89c5d918e684"
      unitRef="shares">20831000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesRestrictedStock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtMS0xLTEtMA_308529ed-1f3e-4c8e-97f9-add32f57d819"
      unitRef="shares">72000</us-gaap:WeightedAverageNumberOfSharesRestrictedStock>
    <us-gaap:WeightedAverageNumberOfSharesRestrictedStock
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtMy0xLTEtMA_790be9f7-ebae-47ce-bf2f-c24a024230dc"
      unitRef="shares">141000</us-gaap:WeightedAverageNumberOfSharesRestrictedStock>
    <us-gaap:WeightedAverageNumberOfSharesRestrictedStock
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzQtNS0xLTEtMA_95cdefb4-bd42-4ec4-ab52-d9d1ed5d290c"
      unitRef="shares">0</us-gaap:WeightedAverageNumberOfSharesRestrictedStock>
    <us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtMS0xLTEtMA_e5d980f0-230f-4491-af14-da5cb33958de"
      unitRef="shares">1125000</us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements>
    <us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtMy0xLTEtMA_231b912f-1f70-49e2-8520-ca23adac30bf"
      unitRef="shares">1000000</us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements>
    <us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzUtNS0xLTEtMA_026ff0a9-f5a1-4c3e-8ab4-112020981ea6"
      unitRef="shares">0</us-gaap:IncrementalCommonSharesAttributableToShareBasedPaymentArrangements>
    <us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtMS0xLTEtMA_50148f78-9862-4d26-a16c-029a354af27c"
      unitRef="shares">1017000</us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants>
    <us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtMy0xLTEtMA_d58b1145-f299-4590-96a3-e1c318db8140"
      unitRef="shares">94000</us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants>
    <us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzYtNS0xLTEtMA_0270d480-2337-44f7-a96b-046835431238"
      unitRef="shares">0</us-gaap:IncrementalCommonSharesAttributableToCallOptionsAndWarrants>
    <us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctMS0xLTEtMA_baefd9c3-0cba-4667-8658-ff66b23ac3e8"
      unitRef="shares">693000</us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities>
    <us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctMy0xLTEtMA_f104d0e9-ff43-4fe3-a445-37da4c85a827"
      unitRef="shares">1214000</us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities>
    <us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzctNS0xLTEtMA_066bb727-d9cf-40d7-a971-832c595ada5e"
      unitRef="shares">0</us-gaap:IncrementalCommonSharesAttributableToConversionOfDebtSecurities>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtMS0xLTEtMA_3388c69a-7883-4661-9fd2-c822abb13f3e"
      unitRef="shares">24067000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtMy0xLTEtMA_44c35448-d081-4482-b60f-5f172e7964a7"
      unitRef="shares">23481000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzgtNS0xLTEtMA_096af056-ee91-4e0d-bec8-a3048e99a897"
      unitRef="shares">20831000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktMS0xLTEtMA_45d7ccf6-330d-441a-b96e-4294d065f6e2"
      unitRef="shares">2845000</us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
    <us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktMy0xLTEtMA_3ada5c2c-c1fa-4d34-b978-2c2ba9eb9419"
      unitRef="shares">335000</us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
    <us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90YWJsZTo3ODdiNDQxZGZhMmI0YzhjOGYwYjI2ZjczMTQ4ODQzZS90YWJsZXJhbmdlOjc4N2I0NDFkZmEyYjRjOGM4ZjBiMjZmNzMxNDg4NDNlXzktNS0xLTEtMA_63b1440b-e1ae-4a21-a28b-962beba56930"
      unitRef="shares">3544000</us-gaap:AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount>
    <us-gaap:ComprehensiveIncomePolicyPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE2NDkyNjc1NTc2OTc_b52a8307-3eb0-4718-9eb9-c09f041a2237">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Comprehensive Income (Loss)&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Comprehensive income (loss) represents net income (loss) adjusted for the change during the periods presented in unrealized gains and losses on available-for-sale securities, foreign currency translation adjustments, and reclassification adjustments for realized gains or losses included in net income (loss). The unrealized gains or losses are reported on the Consolidated Statements of Comprehensive Income (Loss).&lt;/span&gt;&lt;/div&gt;</us-gaap:ComprehensiveIncomePolicyPolicyTextBlock>
    <us-gaap:ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzE2NDkyNjc1NTc2OTg_18e39cba-eae0-42af-b710-a96af7a3283b">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Foreign Currency Translation&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;The British Pound Sterling is the functional currency of Vernalis and the corresponding financial statements have been translated into U.S. Dollars in accordance with ASC 830-30, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;"&gt;Translation of Financial Statements&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;. Assets and liabilities are translated at end-of-period rates while revenues and expenses are translated at average rates in effect during the period in which the activity took place. Equity is translated at historical rates and the resulting cumulative translation adjustments are included as a component of accumulated other comprehensive income (loss).&lt;/span&gt;&lt;/div&gt;</us-gaap:ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock>
    <us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzQxMjc5_8693c5be-c79a-43e6-bccd-636cbaa37bec">Accounting Standards Recently Adopted&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Revenue Recognition &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;- In May 2014, the FASB issued new guidance related to revenue recognition, ASU 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10 and 2016-12, which outlines a comprehensive revenue recognition model and supersedes most current revenue recognition guidance. The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services. ASC 606 defines a five-step approach for recognizing revenue, which may require a company to use more judgment and make more estimates than under the current guidance. We adopted this new standard as of January 1, 2018, by using the modified-retrospective method. See &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Royalties&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Licenses Fees and Milestones&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Material Sales&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;, and &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Disaggregation of Revenue&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; subsections mentioned above for further information. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Financial Instruments&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; - In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10), which requires equity investments (other than those accounted for under the equity method or those that result in consolidation) to be measured at fair value, with changes in fair value recognized in net income. We have strategic investments, including Viking, that fall under this guidance update. We have adopted ASU 2016-01 effective January 1, 2018 as a cumulative-effect adjustment and reclassified $2.7 million unrealized gains on equity investments, net of tax, from accumulated other comprehensive income to accumulated deficit on our consolidated balance sheet. Effective January 1, 2018, our results of operations include the changes in fair value of these financial instruments. S&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;ee &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Item 8. Financial Statements and Supplementary Data&#x2014;Notes to Consolidated Financial Statements&#x2014;Note (2), Investment in Viking&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#x201d; for additional information.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Stock Compensation&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;font-style:italic;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;- In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718), which aims to simplify the accounting for share-based payment transactions, including accounting for income taxes, classification on the statement of cash flows, accounting for forfeitures, and classification of awards as either liabilities or equity. We have adopted this standard effective January 1, 2017. This standard increases the volatility of net income by requiring excess tax benefits from share-based payment arrangements to be classified as discrete items within the provision for income taxes, rather than recognizing excess tax benefits in additional paid-in capital. Upon adoption in the first quarter of 2017, we recorded $17.6 million to accumulated deficit on our consolidated balance sheet, primarily related to unrealized tax benefits associated with share-based compensation. Also, as a result of the adoption of this new standard, we made an accounting policy election to recognize forfeitures as they occur and will no longer estimate expected forfeitures.&#160;In addition, excess income tax benefits from share-based compensation arrangements are classified as cash flows from operations, rather than cash flows from financing activities. We elected to apply the cash flows classification guidance prospectively and have not adjusted prior periods.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;"&gt;Statement of Cash Flows&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; - In August 2016 the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments. The new standard clarifies certain aspects of the statement of cash flows, and aims to reduce diversity in practice regarding how certain transactions are classified in the statement of cash flows. This standard was effective January 1, 2018. We adopted ASU 2016-15 effective January 1, 2018. For the year ended December 31, 2017, we have reclassed&#160;$5.0 million&#160;payments to CVR holders and other contingency payments from investing activities to operating activities. For the year ended December 31, 2016, we have reclassed $8.8 million&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;payments to CVR holders and other contingency payments from investing activities to operating activities and financing activities in amount of $2.3 million and $6.5 million, respectively.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;&#160;In addition, in November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230), Restricted Cash. The standard requires that a statement of cash flows explains the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, restricted cash should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The new guidance is effective for interim and annual periods beginning after December 15, 2017. We adopted this standard retrospectively, effective January 1, 2018 and included restricted cash amount of&#160;$2.6 million, which was included in other current assets in our consolidated balance sheet as of December&#160;31, 2018, in the consolidated statement of cash flows. &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;See additional information in &#x201c;Footnote 7. Balance Sheet Account Details.&#x201d;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;We did not have any restricted cash as of December&#160;31, 2017 and&#160;2016&#160;.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accounting Standards Not Yet Adopted&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Leases&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This standard requires organizations that lease assets to recognize the assets and liabilities created by those leases. The standard also will require disclosures to help investors and other financial statement users better understand the amount, timing, and uncertainty of cash flows arising from leases. The ASU becomes effective for public companies for fiscal years and interim periods within those fiscal years, beginning after December 15, 2018. In 2018, the FASB issued guidance that provides an optional transition method for adoption of this standard, which allows organizations to initially apply the new requirements at the effective date, recognize a cumulative effect adjustment to the opening balance of retained earnings, and continue to apply the legacy guidance in ASC 840, Leases,&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; including its disclosure requirements, in the comparative periods presented. We adopted this standard on January 1, 2019 by applying&#160;this optional transition method. For leases with a term of 12 months or less, we elected to not recognize lease assets and lease liabilities and expense the leases over a straight-line basis for the term of those leases. The adoption of this standards update resulted in no material impact to our balance sheet, statement of operations, equity&#160;or cash flows.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Financial Instruments&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. ASU 2016-13 is effective for us beginning in the first quarter of 2020, with early adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Fair Value Measurement&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; - In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement: Disclosure Framework&#x2014; Changes to the Disclosure Requirements for Fair Value Measurement (Topic 820), which modifies the disclosure requirements on fair value measurements. ASU 2018-13 is effective for us beginning in the first quarter of 2020, with earlier adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We do not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on our consolidated financial statements or disclosures.&lt;/span&gt;&lt;/div&gt;</us-gaap:NewAccountingPronouncementsPolicyPolicyTextBlock>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="if6d885e1e1c9488c9c8b980b72ab5539_I20180101"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyMDUyMA_432ec312-fd45-4888-b0ea-c8b9939ef441"
      unitRef="usd">-2700000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption
      contextRef="ib96266c9cd9e42b68a5de54609fb51bd_I20170101"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzI3NDg3NzkxOTUwNzY_d31eef75-2a01-4cac-a3a0-457b775d6b10"
      unitRef="usd">17600000</us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption>
    <us-gaap:NetCashProvidedByUsedInInvestingActivities
      contextRef="ib6a2d0bf8bbd44f7a2e8072d058855a0_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0MTQ_4b7e9e0e-9aeb-4df8-9c8c-1200e3c68d5b"
      unitRef="usd">-5000000.0</us-gaap:NetCashProvidedByUsedInInvestingActivities>
    <us-gaap:NetCashProvidedByUsedInInvestingActivities
      contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0MzI_ebb0981d-294b-41fc-b1f8-fb098ccded77"
      unitRef="usd">-8800000</us-gaap:NetCashProvidedByUsedInInvestingActivities>
    <us-gaap:NetCashProvidedByUsedInOperatingActivities
      contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0NDk_6b83fc88-9f45-460d-8e36-e121d681fac7"
      unitRef="usd">2300000</us-gaap:NetCashProvidedByUsedInOperatingActivities>
    <us-gaap:NetCashProvidedByUsedInFinancingActivities
      contextRef="ib7b319f25e4a46f8a928891c2ddb927a_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzIxOTkwMjMzNzI0NTY_ad90d5f2-d65d-42d6-a6ac-30564fcc06f4"
      unitRef="usd">6500000</us-gaap:NetCashProvidedByUsedInFinancingActivities>
    <us-gaap:RestrictedCashCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zNTkvZnJhZzo2YzZlMTk5YzBiZWU0Njc3YmJjYmRkOWUxOGIwMzdkMi90ZXh0cmVnaW9uOjZjNmUxOTljMGJlZTQ2NzdiYmNiZGQ5ZTE4YjAzN2QyXzU0OTc1NTkyNDU0Nw_ac056d5c-15b8-4f3f-b039-cc5522111700"
      unitRef="usd">2600000</us-gaap:RestrictedCashCurrent>
    <us-gaap:VariableInterestEntityDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU4OTI_c2a80f7f-bf07-40c5-adde-7a20a668c3ff">Investment in Viking&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our current ownership in Viking is approximately&#160;8.8%&#160;and&#160;we account it as investment in an available-for-sale security&#160;due to the fact that 1) we do not have the ability to exercise significant&#160;influence over Viking,&#160;2) we are not involved in Viking's&#160;ongoing operations, and 3) Viking does not rely on us to provide technology products, expertise, support or services.&#160;Our investment in Viking is measured at fair value, with changes in fair value recognized in net income.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Our ownership in Viking was 17.6%&#160;and 30.3%&#160;as of December 31, 2017 and 2016, respectively. As a result of Viking's public stock offerings, we recorded a dilution gain of $2.7 million and a dilution loss of $10.7 million for the years ended December 31, 2017 and 2016, respectively. These amounts were recognized in Loss from Viking in our consolidated statement of operations. Our equity ownership interest in Viking decreased during the first quarter of 2018 to approximately 12.4% due to Viking's financing events in February 2018. As a result, in February 2018, we concluded that we did not exert significant influence over Viking and discontinued accounting for our investment in Viking under the equity method. Viking is considered a related party as we maintain a seat on Viking's board of directors.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Ligand and&#160;Viking were previously parties to a Loan and Security Agreement, dated May 21, 2014 (as amended by the First&#160;Amendment to Loan and Security Agreement, dated April 8, 2015, and the Second Amendment to Loan and Security Agreement, dated&#160;January 22, 2016, the &#x201c;Loan and Security Agreement&#x201d;), pursuant to which we loaned $2.5 million to Viking. Such debt was&#160;evidenced by a Senior Convertible Promissory Note (the &#x201c;Convertible Note&#x201d;).&#160;Pursuant to the terms of the Loan and Security Agreement, upon the consummation of the Follow-On Public Offering on April 13,&#160;2016, Viking repaid us&#160;$1.5 million, which payment was composed of&#160;$0.3 million in cash, with the remaining balance paid&#160;in Viking&#x2019;s equity securities, resulting in the issuance of 960,000 shares of common stock to us in the Follow-On Public&#160;Offering. Such payment was applied, first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal&#160;amount of the Convertible Note. On July 15, 2017, Viking repaid an additional $0.2 million in cash. Such payment was applied,&#160;first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal amount of the Convertible Note. On&#160;May 23, 2018, the Convertible Note was repurchased in full by Viking for $3.9 million in cash. As of December 31, 2018, the Convertible Note and Loan and&#160;Security Agreement are no longer outstanding.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We also have outstanding warrants to purchase 1.5 million shares of Viking's common stock at an exercise price of $1.50 per share. We recorded the warrants in other current assets in our consolidated balance sheets at fair value of $9.3 million and $3.9 million at December&#160;31, 2018 and 2017, respectively.&#160;For the years ended December&#160;31, 2018, 2017 and 2016, a gain of $5.4 million, $3.2 million and $0.3 million on the fair market value of the warrants, respectively, was included within other income. See further discussion in &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Note (4), Fair Value Measurement.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#x201d;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Prior to the adoption of ASU 2016-01, we reviewed our investment in Viking on a regular basis and assess whether events, changes in circumstances or the passage of time, in management's judgment, indicate that a loss in the market value of the investment may be other than temporary. This might include, but would not necessarily be limited to, the period of time during which the carrying value of our investment is significantly above the observed market value, a deterioration in Viking's financial condition, or an adverse event relating to its lead clinical programs. &lt;/span&gt;&lt;/div&gt;Based on a sustained low Viking common stock unit price during the year ended December 31, 2016, we determined that an other than temporary decrease in the value of our investment in Viking had occurred. We wrote down the value of our&#160;investment in Viking to its estimated fair value which resulted in impairment charges of&#160;$7.4 million&#160;for the year ended December 31, 2016. Subsequent to the adoption of ASU 2016-01, we no longer account for our investment in Viking under the equity method; instead, it&#160;is measured at fair value, with changes in fair value recognized in net income.</us-gaap:VariableInterestEntityDisclosureTextBlock>
    <us-gaap:LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest
      contextRef="i4f2d6682161c4d8580620d72aac72bec_D20180101-20181231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU0OTc1NTgzNTIyNg_2ac81b30-630c-4168-8490-c53a30ce2b53"
      unitRef="number">0.088</us-gaap:LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest>
    <us-gaap:EquityMethodInvestmentOwnershipPercentage
      contextRef="ia92a709872af454ba4a10e9e097a3942_I20171231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ1MjA_e28f113c-228e-4e4f-ae23-bc35b8d6ec23"
      unitRef="number">0.176</us-gaap:EquityMethodInvestmentOwnershipPercentage>
    <us-gaap:EquityMethodInvestmentOwnershipPercentage
      contextRef="i1495b46d310b40f39b5ba48f1a435973_I20161231"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjE3Mjc_69d739de-bf50-46c7-b44d-473c6b163cba"
      unitRef="number">0.303</us-gaap:EquityMethodInvestmentOwnershipPercentage>
    <lgnd:IncreaseDecreaseinEquityMethodInvestment
      contextRef="ia6fd586e979f42b98e809e8789d74966_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ2NTc_136a9eb1-9df1-496d-815c-8760fae15414"
      unitRef="usd">2700000</lgnd:IncreaseDecreaseinEquityMethodInvestment>
    <lgnd:IncreaseDecreaseinEquityMethodInvestment
      contextRef="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzQ2ODM_a9a56075-aacd-4e17-b9a4-225b2b9e16a1"
      unitRef="usd">-10700000</lgnd:IncreaseDecreaseinEquityMethodInvestment>
    <lgnd:VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded
      contextRef="i752433d6202a4b8d86205c212edea90e_D20180101-20180331"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxMTQ_becd3d32-6bc1-4dd5-9e84-2e2e798ef2a0"
      unitRef="number">0.124</lgnd:VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded>
    <us-gaap:VariableInterestEntityFinancialOrOtherSupportAmount
      contextRef="iaffe39f2d0954dbd80e0485f4618b93a_D20140501-20140531"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODc2Nzk_03577d64-5922-4552-bf90-cecf72daf1e4"
      unitRef="usd">2500000</us-gaap:VariableInterestEntityFinancialOrOtherSupportAmount>
    <lgnd:NoteReceivableAmountDueUponTriggeringEvent
      contextRef="i383f1359ee76425995b33bc12c23ab90_I20160131"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg4ODY_e6ee3c73-b92f-4c04-919f-ba88030f1495"
      unitRef="usd">1500000</lgnd:NoteReceivableAmountDueUponTriggeringEvent>
    <us-gaap:ProceedsFromCollectionOfNotesReceivable
      contextRef="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg5MDM_b017d7ca-dfeb-42c0-a452-71ec5ef4866f"
      unitRef="usd">300000</us-gaap:ProceedsFromCollectionOfNotesReceivable>
    <lgnd:EquityMethodInvestmentSharesReceivedLicensingAgreement
      contextRef="i5fb26e6357e0409b984c65215324cf82_D20160413-20160413"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODg5OTg_0f834d5e-2b64-4bed-afa1-c63214a0e565"
      unitRef="shares">960000</lgnd:EquityMethodInvestmentSharesReceivedLicensingAgreement>
    <lgnd:NoteReceivableCashDueUponTriggeringEvent
      contextRef="i8c3752abd1af4925883b62910e38900f_I20170715"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODkwNjU_130c10f9-9c4c-4f3b-b42e-af8695636437"
      unitRef="usd">200000</lgnd:NoteReceivableCashDueUponTriggeringEvent>
    <us-gaap:OtherSignificantNoncashTransactionValueOfConsiderationReceived1
      contextRef="i77dbc1a726434cedaf60137ef4ee8652_D20180523-20180523"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODkxMTU_9221b6aa-ac96-4776-a571-32f448c9d272"
      unitRef="usd">3900000</us-gaap:OtherSignificantNoncashTransactionValueOfConsiderationReceived1>
    <us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
      contextRef="if138f3f9b2b74770a5cce6db84ab24b9_I20160430"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjg5MDM_6b25efae-53a5-451a-a30e-3d6ec8124080"
      unitRef="usdPerShare">1.50</us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1>
    <us-gaap:WarrantsAndRightsOutstanding
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjI2NDc_ae68ed30-8413-45ce-9cef-a6f73f27bcfb"
      unitRef="usd">9300000</us-gaap:WarrantsAndRightsOutstanding>
    <us-gaap:WarrantsAndRightsOutstanding
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzIxOTkwMjMyNjI2NjU_2185858f-3f85-46d3-9bff-37abb6d2a2c7"
      unitRef="usd">3900000</us-gaap:WarrantsAndRightsOutstanding>
    <us-gaap:FairValueOptionChangesInFairValueGainLoss1
      contextRef="ia743eb727a504f64a2e98f6fafd87f67_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxNjk_f3491f93-8f62-4f2b-849c-90aba0693fbf"
      unitRef="usd">5400000</us-gaap:FairValueOptionChangesInFairValueGainLoss1>
    <us-gaap:FairValueOptionChangesInFairValueGainLoss1
      contextRef="i487a7d2c1cd749679482b85797456924_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxNzM_858d640f-299b-4035-809b-60efc4e0b592"
      unitRef="usd">3200000</us-gaap:FairValueOptionChangesInFairValueGainLoss1>
    <us-gaap:FairValueOptionChangesInFairValueGainLoss1
      contextRef="i07d723f5c7634c8f84df7f866754f3e9_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzI3NDg3NzkwODYxODA_17d475e9-4d3b-453c-a0d0-70d67e9a747b"
      unitRef="usd">300000</us-gaap:FairValueOptionChangesInFairValueGainLoss1>
    <us-gaap:ImpairmentOfInvestments
      contextRef="i2a1e87471f4549548e3126ebe25e2876_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zODQvZnJhZzpiNGY3NTBiOWI0OGI0MGU3ODk0YTNjMGRkMzgwNTU4ZS90ZXh0cmVnaW9uOmI0Zjc1MGI5YjQ4YjQwZTc4OTRhM2MwZGQzODA1NThlXzU3NTA_5f908c8f-3995-443d-a22d-fbb697d91c93"
      unitRef="usd">7400000</us-gaap:ImpairmentOfInvestments>
    <us-gaap:BusinessCombinationDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE2NDkyNjc0NTc0MjY_cb8e19d0-eee7-4318-b72f-940e36ab2f33">Business Combinations&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt;As set forth below, we completed three acquisitions from January 1, 2016 through December 31, 2018, and all were&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; accounted for as business combinations.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"&gt; We applied&#160;the acquisition method of accounting. Accordingly, we recorded the tangible and intangible assets acquired and liabilities assumed at their estimated fair values as of the applicable date of acquisition. For each acquisition, we did not incur any material&#160;acquisition&#160;related costs.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Vernalis Acquisition&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In October 2018, we acquired Vernalis, a structure-based drug discovery biotechnology company for $43.0 million, funded through cash on hand. The acquisition of Vernalis increases our overall portfolio of fully-funded programs. As&#160;Vernalis' operations are not considered material, pro forma information is not provided.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The preliminary allocation of the consideration&#160;was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:97.076023%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.518072%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.481928%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash and cash equivalents&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;34,286&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restricted cash&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,836&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other assets&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,383&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Accounts payable and accrued liabilities&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,403)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restructuring and product reserves&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(7,118)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred revenue&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(746)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Intangibles assets with finite life - core technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,740&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;42,978&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;None of the goodwill is deductible for tax purposes. The fair value of the core technologies were based on the discounted cash flow method that estimated the present value of the hypothetical royalty/milestone streams derived from the licensing of the related technologies.  These projected cash flows were discounted to present value using a discount rate of&#160;34.0%. The fair value of the core technology is being amortized on a straight-line basis over the weighted average estimated useful life of approximately nine years.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The estimated fair values of assets acquired and liabilities assumed, including deferred tax assets and liabilities, purchased intangibles and deferred revenue are provisional. The accounting for these amounts falls within the measurement period and therefore we may adjust these provisional amounts to reflect new information obtained about facts and circumstances that existed as of the acquisition date.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Crystal Acquisition&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;On October 6, 2017, we acquired all of the assets and liabilities of Crystal. Crystal is a biotechnology company focused in avian genetics and the generation of fully-human therapeutic engineering of animals for the generation of fully-human therapeutic antibodies through its OmniChicken&#xae; technology. Under the terms of the agreement, we were to pay Crystal selling shareholders $27.2 million in cash including a $2.2 million&#160;working capital adjustment, and up to an additional $10.5 million&#160;of cash consideration based on Crystal&#x2019;s achievement of certain research and business milestones prior to December&#160;31, 2019. In addition, Crystal&#x2019;s selling shareholders will receive 10% of revenues realized by Ligand above&#160;$15 million between the closing date and December&#160;31, 2022 from&#160;existing collaboration agreements between Crystal and&#160;three&#160;of its collaborators, and Crystal&#x2019;s selling shareholders will receive 20% of revenues above&#160;$1.5 million&#160;generated between the closing date and &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; December&#160;31, 2022 pursuant to a fourth existing collaboration agreement with a large pharmaceutical company. As of December&#160;31, 2018, $0.2 million of the initial $27.2 million of cash consideration remained outstanding.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;At the closing of the acquisition, we recorded an&#160;$8.4 million contingent liability for amounts potentially due to Crystal shareholders. The initial fair value of the liability was determined using a probability weighted income approach incorporating the estimated future cash flows from potential milestones and revenue sharing. These cash flows were then discounted to present value using discount rates based on&#160;our estimated corporate credit rating, and averaged to approximately 4.6%. Refer to &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Note 4 Fair Value Measurement &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;for further discussion. The liability has been periodically assessed based on events and circumstances related to the underlying milestones, and any changes in fair value are recorded in our consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. There was no change in the fair value of the contingent liabilities from the initial valuation date to December&#160;31, 2018.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The aggregate acquisition consideration was determined to be $35.7 million, consisting of (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.411765%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.588235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash paid to Crystal shareholders&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash payable to Crystal Shareholders&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;336&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assumed liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;129&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of contingent consideration&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;35,743&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:78.498534%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:17.501466%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Cash and cash equivalents&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;224&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Accounts receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,513&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Prepaid expenses and other assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;201&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Property and equipment, net&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;589&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Current liabilities assumed&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(354)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Deferred revenue&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,624)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;     Deferred tax liabilities, net&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(9,503)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;     Intangible asset with finite life - core technology&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,697&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;35,743&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The fair value of the core technology, or OmniChicken technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniChicken technology. These projected cash flows were discounted to present value using a discount rate of&#160;10.8%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of&#160;20 years.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $10.7 million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to Crystal&#x2019;s potential revenue growth from combining the Crystal and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;OMT Acquisition&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;On January 8, 2016, we acquired substantially all of the assets and liabilities of OMT. OMT is a biotechnology company engaged in the genetic engineering of animals for the generation of human therapeutic antibodies through its OmniAb&#xae; technology. The aggregate acquisition consideration was $173.4 million, consisting of (in thousands, except per share amounts):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.411765%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.588235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;96,006&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total share consideration:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;  Actual number of shares issued&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;790&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;  Multiplied by: Ligand closing share price on January 8, 2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;98&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total share consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;77,373&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;173,379&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:78.498534%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:17.501466%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Cash and cash equivalents&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,504&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Accounts receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Income tax receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;136&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Prepaid expenses and other current assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Deferred tax liabilities, net&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(55,708)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Intangible asset with finite life - core technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;167,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Liabilities assumed&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,528)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;59,969&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;173,379&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The fair value of the core technology, or OMT's OmniAb technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniAb technology. These projected cash flows were discounted to present value using a discount rate of 15.5%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of 20 years.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $60.0 million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to OMT&#x2019;s potential revenue growth from combining the OMT and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.&lt;/span&gt;&lt;/div&gt;</us-gaap:BusinessCombinationDisclosureTextBlock>
    <us-gaap:PaymentsToAcquireBusinessesGross
      contextRef="i38901eeb0e374312bb0a645919532284_D20181001-20181031"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTgxNQ_cc9d5df8-49e8-44c5-b63e-682f84be2b84"
      unitRef="usd">43000000.0</us-gaap:PaymentsToAcquireBusinessesGross>
    <us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock
      contextRef="ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE2NDkyNjc0NTc0Mjc_01f1362d-a164-4ad0-8852-b77d49867f5a">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The preliminary allocation of the consideration&#160;was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:97.076023%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.518072%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.481928%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash and cash equivalents&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;34,286&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restricted cash&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,836&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other assets&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,383&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Accounts payable and accrued liabilities&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,403)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restructuring and product reserves&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(7,118)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred revenue&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(746)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Intangibles assets with finite life - core technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,740&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;42,978&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzAtMS0xLTEtNDM1OQ_f13feb31-1333-4299-b142-33a7107cfd34"
      unitRef="usd">34286000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents>
    <lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzEtMS0xLTEtNDM1OQ_89991e6f-3c7d-4425-935b-ece6e67d7be5"
      unitRef="usd">2836000</lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzItMS0xLTEtNDM1OQ_8d01cd5d-1f64-436f-bd65-d77e258adcd9"
      unitRef="usd">6383000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzMtMS0xLTEtNDM1OQ_82e471a6-c882-4403-8bfe-e1f8b062452c"
      unitRef="usd">3403000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable>
    <us-gaap:RestructuringReserve
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzQtMS0xLTEtMTU1NDY_d6f65ef5-c90d-4126-afce-efdbae1b47d5"
      unitRef="usd">7118000</us-gaap:RestructuringReserve>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzQtMS0xLTEtNDM1OQ_37e737c4-4942-4e0f-94d7-f9590917503c"
      unitRef="usd">746000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzctMS0xLTEtNDM1OQ_ecc1ca84-a201-48b9-a896-aa8f131f59df"
      unitRef="usd">7000000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles>
    <us-gaap:Goodwill
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzgtMS0xLTEtNDM1OQ_6ed9a10c-77d5-4292-968e-b9f8d4fd9e39"
      unitRef="usd">3740000</us-gaap:Goodwill>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZToxMzJlNzUzYWQxYWU0NTAwYjczZjVlNDRlNWNlOGZjMy90YWJsZXJhbmdlOjEzMmU3NTNhZDFhZTQ1MDBiNzNmNWU0NGU1Y2U4ZmMzXzctMS0xLTEtODI1MQ_bbc0bf11-8e41-47da-be64-49335bcb5f6b"
      unitRef="usd">42978000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate
      contextRef="ia38dbfb0e11c4a9a882737b3a381dc65_I20181031"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTY3Mw_2e93c5ff-70ea-45db-af1e-db8fbf232ce9"
      unitRef="number">0.340</lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate>
    <us-gaap:FiniteLivedIntangibleAssetUsefulLife
      contextRef="iaa145923f25048de937e04721b4c84da_D20181001-20181031"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTgxMg_87e0d45f-8d7d-4c18-9750-921146b88f7d">P9Y</us-gaap:FiniteLivedIntangibleAssetUsefulLife>
    <us-gaap:PaymentsToAcquireBusinessesGross
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ0Mw_c3433627-76e9-4e3b-b49e-ee530811abf3"
      unitRef="usd">27200000</us-gaap:PaymentsToAcquireBusinessesGross>
    <lgnd:WorkingCapitalAdjustment
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ2NA_e37820d8-ba95-48ab-a0ce-3404e22f610d"
      unitRef="usd">2200000</lgnd:WorkingCapitalAdjustment>
    <us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzUzMg_80a05c2d-9d0e-4919-9a7e-80ee1b1ffc59"
      unitRef="usd">10500000</us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned>
    <lgnd:RevenueRoyaltytoAcquireeShareholdersPercent
      contextRef="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzcwOQ_aa9d3a11-6082-4402-927d-ab87681afd3b"
      unitRef="number">0.10</lgnd:RevenueRoyaltytoAcquireeShareholdersPercent>
    <lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments
      contextRef="i78b1cd0d3c704dfb960dfdb7a3e4c6d9_D20171006-20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzc0OQ_42bb4e42-aa73-46eb-bd66-c852546fee0d"
      unitRef="usd">15000000</lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments>
    <lgnd:RevenueRoyaltytoAcquireeShareholdersPercent
      contextRef="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzkyNg_9a8b2733-cf61-46dc-8ad4-099cc9450e83"
      unitRef="number">0.20</lgnd:RevenueRoyaltytoAcquireeShareholdersPercent>
    <lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments
      contextRef="if70863a553a04501951ab4d8ad259e4d_D20171006-20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzk0Nw_65776488-cb30-4675-899d-29aaa6dd83dc"
      unitRef="usd">1500000</lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments>
    <lgnd:NumberofCollaborationAgreements
      contextRef="i57c56b2221e94885a3513e61361de5d2_I20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzEwMjE_ee2af603-79cb-4ea5-b362-3439aec45be0"
      unitRef="numberofcollaborationagreements">4</lgnd:NumberofCollaborationAgreements>
    <lgnd:CashPayable
      contextRef="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzIxOTkwMjMyNzE4OTU_452f3c9a-4d33-430d-9907-b2a84115eb15"
      unitRef="usd">200000</lgnd:CashPayable>
    <us-gaap:PaymentsToAcquireBusinessesGross
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzExMjI_b081decf-35d2-45c7-a35e-a8995e258ffe"
      unitRef="usd">27200000</us-gaap:PaymentsToAcquireBusinessesGross>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzEyOTE_dc9f15b6-9897-480b-b4b4-edbdb8188e8c"
      unitRef="usd">8400000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration>
    <lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate
      contextRef="i0a8ca3d45f2d43049621874687484bb9_I20171006"
      decimals="3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzE3MjU_73132d54-b794-4fbb-b6e4-c00acf0ed01e"
      unitRef="number">0.046</lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate>
    <lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock
      contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjE_7b0e6001-5227-4c67-9fb2-bed8fe93363f">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The aggregate acquisition consideration was determined to be $35.7 million, consisting of (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.411765%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.588235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash paid to Crystal shareholders&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash payable to Crystal Shareholders&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;336&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assumed liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;129&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of contingent consideration&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;35,743&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzIzNDE_1a183270-8171-4028-a55a-fd078fb3b38f"
      unitRef="usd">35700000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <lgnd:CashPaidtoAcquireBusiness
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzAtMS0xLTEtMA_f72ea379-61f2-4a0e-b6c5-202da80f7200"
      unitRef="usd">26877000</lgnd:CashPaidtoAcquireBusiness>
    <lgnd:CashPayable
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzEtMS0xLTEtMA_fe57fda0-20ff-4e22-839e-209512abf3a3"
      unitRef="usd">336000</lgnd:CashPayable>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzItMS0xLTEtMA_b034bfab-45a8-4a35-b0be-19d5cf0f1320"
      unitRef="usd">129000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration
      contextRef="id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzMtMS0xLTEtMA_f64af588-a993-425f-a59c-edf0bbf8e520"
      unitRef="usd">8401000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpmZmQ4MDRiM2U0Yjg0OGU4YjEyYmYwNWU1MDMzNjZmZi90YWJsZXJhbmdlOmZmZDgwNGIzZTRiODQ4ZThiMTJiZjA1ZTUwMzM2NmZmXzQtMS0xLTEtMA_aeea9461-5b17-46fc-a821-a2c14089e20f"
      unitRef="usd">35743000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock
      contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjI_a44e1845-7653-4460-ab33-dbbae67ab0bb">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:78.498534%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:17.501466%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Cash and cash equivalents&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;224&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Accounts receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,513&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Prepaid expenses and other assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;201&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Property and equipment, net&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;589&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Current liabilities assumed&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(354)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Deferred revenue&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,624)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;     Deferred tax liabilities, net&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(9,503)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;     Intangible asset with finite life - core technology&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,697&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;35,743&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzAtMS0xLTEtMA_e93302c3-70d1-4ee9-89ae-453c3b6c639f"
      unitRef="usd">224000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzEtMS0xLTEtMA_7fc170e9-ae10-4209-ad9d-6d5e17890df5"
      unitRef="usd">2513000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzItMS0xLTEtMA_0f208af7-cb61-44d2-acc5-7063230a8e1f"
      unitRef="usd">201000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzMtMS0xLTEtMA_50995193-783f-4be3-a2d5-a62f45603843"
      unitRef="usd">589000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzQtMS0xLTEtMA_b0cc431f-3f1c-4f02-99e8-d89f3bab9c8e"
      unitRef="usd">354000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzUtMS0xLTEtMA_2e508c45-5d53-4d3a-b161-6380eb9754f6"
      unitRef="usd">4624000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzYtMS0xLTEtMA_e50a67d5-ba28-4d28-848a-1ce2a0e2c057"
      unitRef="usd">9503000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzctMS0xLTEtMA_a45e3b47-51b7-4731-8208-933b49767989"
      unitRef="usd">36000000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles>
    <us-gaap:Goodwill
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzgtMS0xLTEtMA_0c318c04-8f1b-4cb3-811f-104703c0dc8a"
      unitRef="usd">10697000</us-gaap:Goodwill>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo0ZmIyZjU1OTdlODA0MGUwODZkOThiOGFkMzE2ZTFiYy90YWJsZXJhbmdlOjRmYjJmNTU5N2U4MDQwZTA4NmQ5OGI4YWQzMTZlMWJjXzktMS0xLTEtMA_0f92e8d9-6c05-41e6-a7f3-0d60d0070fe4"
      unitRef="usd">35743000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate
      contextRef="i0a8ca3d45f2d43049621874687484bb9_I20171006"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzMzNTI_a3aedb6a-a977-4a99-a7e9-5c427abdbf4c"
      unitRef="number">0.108</lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate>
    <us-gaap:FiniteLivedIntangibleAssetUsefulLife
      contextRef="ida162efcc0e64c3698e0382c9a821d87_D20171006-20171006"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzU0OTc1NTgyOTY3MQ_bcb10ca9-d48a-4b87-9421-51556485ac29">P20Y</us-gaap:FiniteLivedIntangibleAssetUsefulLife>
    <us-gaap:Goodwill
      contextRef="if9a0fc3b1b494d80a80b515f64915b07_I20171006"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzM2MjI_2d43cf87-c012-47a9-985e-d566f1bff4ef"
      unitRef="usd">10700000</us-gaap:Goodwill>
    <lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock
      contextRef="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjM_bf51c8f4-a0d8-4c4a-99e0-7b8c7eaaf6a4">The aggregate acquisition consideration was $173.4 million, consisting of (in thousands, except per share amounts):&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:77.411765%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:18.588235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cash consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;96,006&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total share consideration:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;  Actual number of shares issued&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;790&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;  Multiplied by: Ligand closing share price on January 8, 2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;98&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total share consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;77,373&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;173,379&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;</lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock>
    <us-gaap:BusinessCombinationConsiderationTransferred1
      contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQyODg_5fee00d6-d35b-47ca-9b69-d794d1a80dc5"
      unitRef="usd">173400000</us-gaap:BusinessCombinationConsiderationTransferred1>
    <us-gaap:PaymentsToAcquireBusinessesGross
      contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzAtMS0xLTEtMA_961d6535-eedc-4d98-84e6-3ccead4c42e8"
      unitRef="usd">96006000</us-gaap:PaymentsToAcquireBusinessesGross>
    <us-gaap:BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued
      contextRef="i7844febd41eb4b53a782d0e4f4c4b2a2_D20160108-20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzItMS0xLTEtMA_9c4bcdc1-f3ec-42f6-8163-5543f25e4923"
      unitRef="shares">790000</us-gaap:BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued>
    <us-gaap:SharePrice
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzMtMS0xLTEtMA_3e3286c3-5ed4-403d-8be3-c91c8537f507"
      unitRef="usdPerShare">98</us-gaap:SharePrice>
    <us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzQtMS0xLTEtMA_0c1206b0-d480-4d8d-8f68-f3d7dcf20ccd"
      unitRef="usd">77373000</us-gaap:BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTo2ZWJkYTRiYzIwMzE0ZjU2ODc0N2FkOGU4YWQxOWU0OS90YWJsZXJhbmdlOjZlYmRhNGJjMjAzMTRmNTY4NzQ3YWQ4ZThhZDE5ZTQ5XzUtMS0xLTEtMA_771cd6a7-b9a4-4c40-81a1-aed5a14fbd6f"
      unitRef="usd">173379000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock
      contextRef="ib91efec76e5a40dbbd07ef95f08a95d2_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzY1OTcwNjk3ODI0MjQ_02715181-96e8-4b6d-a8bc-ee8699afe4d6">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:78.498534%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:17.501466%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Cash and cash equivalents&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,504&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Accounts receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Income tax receivable&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;136&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Prepaid expenses and other current assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Deferred tax liabilities, net&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(55,708)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Intangible asset with finite life - core technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;167,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Liabilities assumed&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,528)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;59,969&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total consideration&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;173,379&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzAtMS0xLTEtMA_ad9410aa-58a0-459c-9f22-9ce0f6ff7aa7"
      unitRef="usd">3504000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzEtMS0xLTEtMA_f9f51db2-6ff8-4f2d-8215-7d10a4c78f91"
      unitRef="usd">5000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables>
    <lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzItMS0xLTEtMA_aedbfd69-8f20-4d73-8ecf-80b7864126ce"
      unitRef="usd">136000</lgnd:BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzMtMS0xLTEtMA_532103cc-3976-4730-8065-97f02825e77c"
      unitRef="usd">1000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzQtMS0xLTEtMA_f671af89-9cfd-4a7f-ade5-7e41337457fb"
      unitRef="usd">55708000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzUtMS0xLTEtMA_ca3a2b69-3ec8-47da-ae7c-bf26c00c0ac9"
      unitRef="usd">167000000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzYtMS0xLTEtMA_58c6d985-c311-4b1c-9907-fa82369a234d"
      unitRef="usd">1528000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities>
    <us-gaap:Goodwill
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzctMS0xLTEtMA_834e55ea-da74-45bd-a2cb-0c7254566217"
      unitRef="usd">59969000</us-gaap:Goodwill>
    <us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90YWJsZTpiOTI4OTA4ODU3ZDE0ZThmODY3NzVlMmQ0OGY3YTIxMy90YWJsZXJhbmdlOmI5Mjg5MDg4NTdkMTRlOGY4Njc3NWUyZDQ4ZjdhMjEzXzgtMS0xLTEtMA_ccd755ae-76bc-46b7-bbff-1971e585175a"
      unitRef="usd">173379000</us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet>
    <lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate
      contextRef="i1523a02160ea4340b895af4cbcc28c78_I20160108"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ4Mjk_d0f173ad-017b-42df-a8d7-9b375cf50978"
      unitRef="number">0.155</lgnd:BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate>
    <us-gaap:FiniteLivedIntangibleAssetUsefulLife
      contextRef="i17a78122d7374267a4ec43cb6b8f9235_D20160108-20160108"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzQ5NTA_0fbe8918-7093-43cd-8847-1c33a71d06ff">P20Y</us-gaap:FiniteLivedIntangibleAssetUsefulLife>
    <us-gaap:Goodwill
      contextRef="iccecb2c1cc3b4381917487ee6b36dd68_I20160108"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8zOTYvZnJhZzpjMDBjNjQ1MGE3ZGQ0NTNkODFkYTQwNGM1NDU5ZWQ3MC90ZXh0cmVnaW9uOmMwMGM2NDUwYTdkZDQ1M2Q4MWRhNDA0YzU0NTllZDcwXzUwOTk_20fe3bd7-de90-4e3a-a52f-848729221bac"
      unitRef="usd">60000000.0</us-gaap:Goodwill>
    <us-gaap:FinancialInstrumentsDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzUzNjg_b33d32e8-b6a8-461e-b554-125c330b352c">Fair Value Measurement&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We measure certain financial assets and liabilities at fair value on a recurring basis.  Fair value is a market-based measurement that should be determined using assumptions that market participants would use in pricing an asset or liability. We establish a three-level hierarchy to prioritize the inputs used in measuring fair value. The levels are described in the below with level 1 having the highest priority and level 3 having the lowest:&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Level 1 - Observable inputs such as quoted prices in active markets &lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Level 2 - Inputs other than the quoted prices in active markets that are observable either directly or indirectly &lt;/span&gt;&lt;/div&gt;&lt;div style="padding-left:36pt;margin-top:5pt;margin-bottom:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Level 3 - Unobservable inputs in which there is little or no market data, which require the Company to develop its own assumptions&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December&#160;31, 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Measurements at Reporting Date Using&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Quoted Prices in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Active Markets&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;for Identical&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Assets&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Other&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Observable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Unobservable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;2)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;3)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Short-term investments&lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt; (1)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;647,408&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47,517&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;599,891&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Investment in warrants &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(3)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;656,665&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56,774&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;599,891&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Crystal &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;4&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,477&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,477&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Cydex &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;5&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;514&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Metabasis &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;6&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Liability for amounts owed to a former licensor &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;7&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,741&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Measurements at Reporting Date Using&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Quoted Prices in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Active Markets&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;for Identical&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Assets&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Other&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Observable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Unobservable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;2)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;3)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Short-term investments&lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt; (1)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;181,041&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,896&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Note receivable Viking &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(2)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Investment in warrants &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(3)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;188,764&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,742&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Crystal &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;4&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Cydex &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;5&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Metabasis &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;6&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Liability for amounts owed to a former licensor &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;7&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,245&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(1) Amounts Investments in equity securities (including investments in Viking), are classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities. Short-term investments in marketable securities with maturities greater than 90 days are classified as level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(2) The fair value of the Convertible Note receivable from Viking at&#160;December&#160;31, 2017&#160;approximated the book value since the contractual maturity date was within five months from the end of 2017, and there was no plan to extend the maturity date. The fair value at&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;December&#160;31, 2017 was determined using a probability weighted option pricing model. The fair value is subjective and is affected by certain significant input to the valuation model such as the estimated volatility of the common stock, which was estimated to be 75% at December&#160;31, 2017. Changes in these assumptions may materially affect the fair value estimate. For the years ended December&#160;31, 2018&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;December&#160;31, 2017, and December&#160;31, 2016, we reported an increase in the fair value of 0.0 million, an increase in the fair value of&#160;$0.9 million, and a decrease in the fair value of $0.2 million, respectively in "Other, net" of the consolidated statement of operations.&#160;See further discussion in &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;"&gt;Note (2), Investment in Viking.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;&#x201d;&#160;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(3) Investment in warrants, which we received as a result of Viking&#x2019;s partial repayment of the Viking note receivable and our purchase of Viking common stock and warrants in April 2016, is classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities.&#160;See further discussion in &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;"&gt;Note (2), Investment in Viking.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;&#x201d;  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(4) The fair value of Crystal contingent liabilities was determined using a probability weighted income approach. Most of the contingent payments are based on development or regulatory milestones as defined in the merger agreement with Crystal. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#x2019;s estimates regarding the timing and probability of achievement of certain developmental and regulatory milestones. At &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt; December&#160;31, 2018, most of the development and regulatory milestones were estimated to be highly probable of being achieved in 2019. Changes in these estimates may materially affect the fair value. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(5) The fair value of CyDex contingent liabilities was determined based on the income approach. To the extent the estimated future income may vary significantly given the long-term nature of the estimate, we utilize a Monte Carlo model. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#x2019;s estimates of timing and probability of achievement of certain revenue thresholds and developmental and regulatory milestones&#160;which may be achieved and affect amounts owed to former license holders.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(6) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-&#x3b2; agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375.0 million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a&#160;$10.0 million payment upon initiation of a Phase 3 clinical trial. Another Metabasis drug development program, RVT-1502, has been outlicensed to Metavant. RVT-1502 is a novel, orally-bioavailable, small molecule, glucagon receptor antagonist or &#x201c;GRA.&#x201d; We may be entitled to up to $529.0 million in milestone payments and royalties.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(7) The liability for amounts owed to a former licensor is determined using quoted market prices in active markets for the underlying investment received from a partner, a portion of which is owed to a former licensor.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of the level 3 financial instruments as of December&#160;31, 2018 is as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:81.284457%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:14.715543%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Cash payment received as repayment of note receivable&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,877)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instrument assets as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments to CVR holders and other contingency payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,025)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value adjustments to contingent liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,974)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Assets Measured on a Non-Recurring Basis&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We apply fair value techniques on a non-recurring basis associated with valuing potential impairment losses related to our&#160;goodwill,&#160;indefinite-lived intangible assets, long-lived assets, and equity investments.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We evaluate goodwill and indefinite-lived intangible assets annually for impairment and whenever circumstances occur indicating that&#160;goodwill might be impaired. We determine the fair value of our reporting unit based on a combination of inputs, including the market&#160;capitalization of Ligand, as well as Level 3 inputs such as discounted cash flows, which are not observable from the market, directly or indirectly. We determine the fair value of our indefinite-lived intangible assets using the income approach based on Level 3 inputs.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Other than certain indefinite-lived intangible asset, there were no impairment of our goodwill, indefinite-lived assets, or long-lived assets recorded during the three years ended December&#160;31, 2018,&#160;2017 and 2016.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Fair Value of Financial Instruments&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In August 2014 and May 2018, we issued the 2019 Notes and 2023 Notes, respectively. We use&#160;quoted market rates in an inactive market, which are classified as a Level 2 input, to estimate the current fair value of our 2019 and 2023 Notes. The carrying value of the notes does not reflect the market rate. See &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;Note (6), Convertible Senior Notes&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#x201d; for additional information related to the fair value.&lt;/span&gt;&lt;/div&gt;</us-gaap:FinancialInstrumentsDisclosureTextBlock>
    <us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzY1OTcwNjk3ODIyMDI_f0ec3c08-eac9-4976-b1e5-49ed1fb35a81">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December&#160;31, 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Measurements at Reporting Date Using&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Quoted Prices in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Active Markets&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;for Identical&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Assets&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Other&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Observable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Unobservable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;2)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;3)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Short-term investments&lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt; (1)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;647,408&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47,517&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;599,891&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Investment in warrants &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(3)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;656,665&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56,774&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;599,891&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Crystal &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;4&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,477&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,477&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Cydex &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;5&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;514&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Metabasis &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;6&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Liability for amounts owed to a former licensor &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;7&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,741&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;199&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Measurements at Reporting Date Using&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Quoted Prices in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Active Markets&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;for Identical&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Assets&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Other&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Observable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Significant&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Unobservable&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Inputs&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;2)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(Level&#160;3)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Short-term investments&lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt; (1)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;181,041&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,896&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Note receivable Viking &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(2)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Investment in warrants &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(3)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;188,764&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,742&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Crystal &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;4&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,401&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Cydex &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;5&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,589&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Contingent liabilities - Metabasis &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;6&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Liability for amounts owed to a former licensor &lt;/span&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;(&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;7&lt;/sup&gt;&lt;sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"&gt;)&lt;/sup&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Total liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,245&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;284&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,971&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(1) Amounts Investments in equity securities (including investments in Viking), are classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities. Short-term investments in marketable securities with maturities greater than 90 days are classified as level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(2) The fair value of the Convertible Note receivable from Viking at&#160;December&#160;31, 2017&#160;approximated the book value since the contractual maturity date was within five months from the end of 2017, and there was no plan to extend the maturity date. The fair value at&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;December&#160;31, 2017 was determined using a probability weighted option pricing model. The fair value is subjective and is affected by certain significant input to the valuation model such as the estimated volatility of the common stock, which was estimated to be 75% at December&#160;31, 2017. Changes in these assumptions may materially affect the fair value estimate. For the years ended December&#160;31, 2018&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;, &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;December&#160;31, 2017, and December&#160;31, 2016, we reported an increase in the fair value of 0.0 million, an increase in the fair value of&#160;$0.9 million, and a decrease in the fair value of $0.2 million, respectively in "Other, net" of the consolidated statement of operations.&#160;See further discussion in &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;"&gt;Note (2), Investment in Viking.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;&#x201d;&#160;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(3) Investment in warrants, which we received as a result of Viking&#x2019;s partial repayment of the Viking note receivable and our purchase of Viking common stock and warrants in April 2016, is classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities.&#160;See further discussion in &#x201c;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;"&gt;Note (2), Investment in Viking.&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;&#x201d;  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(4) The fair value of Crystal contingent liabilities was determined using a probability weighted income approach. Most of the contingent payments are based on development or regulatory milestones as defined in the merger agreement with Crystal. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#x2019;s estimates regarding the timing and probability of achievement of certain developmental and regulatory milestones. At &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt; December&#160;31, 2018, most of the development and regulatory milestones were estimated to be highly probable of being achieved in 2019. Changes in these estimates may materially affect the fair value. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(5) The fair value of CyDex contingent liabilities was determined based on the income approach. To the extent the estimated future income may vary significantly given the long-term nature of the estimate, we utilize a Monte Carlo model. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#x2019;s estimates of timing and probability of achievement of certain revenue thresholds and developmental and regulatory milestones&#160;which may be achieved and affect amounts owed to former license holders.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(6) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-&#x3b2; agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375.0 million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a&#160;$10.0 million payment upon initiation of a Phase 3 clinical trial. Another Metabasis drug development program, RVT-1502, has been outlicensed to Metavant. RVT-1502 is a novel, orally-bioavailable, small molecule, glucagon receptor antagonist or &#x201c;GRA.&#x201d; We may be entitled to up to $529.0 million in milestone payments and royalties.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"&gt;(7) The liability for amounts owed to a former licensor is determined using quoted market prices in active markets for the underlying investment received from a partner, a portion of which is owed to a former licensor.&lt;/span&gt;&lt;/div&gt;</us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i2233588cfcdd4d1d8216daf3329f3545_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtMS0xLTEtMA_086595ac-7e11-4b38-8834-e529df3ab30e"
      unitRef="usd">647408000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i22719832b06742dcae5a658d47223931_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtMy0xLTEtMA_232b379f-b13e-4191-89d7-c08169cb38db"
      unitRef="usd">47517000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i754ca8ba8ad24cac9f16597b92a3ea5f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtNS0xLTEtMA_e266eb17-2350-42a9-9f46-4062b4d50929"
      unitRef="usd">599891000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ib03a2af9f5d54545a7ec5a4137113457_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzQtNy0xLTEtMA_69ae73e3-5ebf-45eb-b120-ca0a763de070"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i1908cb4c829d42b2844e3bb3f6368f63_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzUtMS0xLTEtODQ4NA_da9ef031-f1ac-4cb4-9b2a-3225e6e9a941"
      unitRef="usd">9257000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i64f8a58aefc1411cafeabef5c6a7b1fd_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtMy0xLTEtMA_48618745-5789-49f4-ac67-25eec8167823"
      unitRef="usd">9257000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ie8c9c9e6cb294fdbb37cef5bce12b5c7_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtNS0xLTEtMA_95053b35-90b4-42e0-a0cf-596ab539bca6"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i36f2d5d73c464b0db83cc19d3975cda9_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzYtNy0xLTEtMA_77d81210-79ad-40f3-a393-2d7d1ede942d"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ie7d6396714744e2880bfbeacc09c78a1_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctMS0xLTEtMA_c674f6ed-0312-4776-a121-591d8b7add03"
      unitRef="usd">656665000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ib357eeae00de4b2f9b1a22317457315f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctMy0xLTEtMA_4089d048-367c-4744-9ef5-7828681565a1"
      unitRef="usd">56774000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctNS0xLTEtMA_ff7734dc-4cc0-4ca8-b631-4e3ca845c97a"
      unitRef="usd">599891000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzctNy0xLTEtMA_04561385-2a2c-48fd-a2f1-aa56c0471e4a"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i8dcdef9f22634f7090bf5d69fcdb1a55_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktMS0xLTEtMA_f024d6a7-96f8-4ac3-a83b-2f20ed26e0d9"
      unitRef="usd">6477000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i337533b66aed409fbb551874229f75dc_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktMy0xLTEtMA_466e284c-ff90-4e3f-a6ed-b7bb15961960"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ibd9630ec50374d25a30576be33a7d809_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktNS0xLTEtMA_1c2a52a1-71b6-4b3e-b549-109e9b1bc466"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="iac4562685c694e1aa2783376bb16c397_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzktNy0xLTEtMA_f8e33190-f27e-48b0-bad6-8d54659f5002"
      unitRef="usd">6477000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="id099ffb3f70c4870880029056f3695be_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTEtMS0xLTA_9a4bf3df-3cd8-42e3-8372-f018a23dc1fb"
      unitRef="usd">514000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i8eaac6d98c2544b09548e8e62b89c4c3_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTMtMS0xLTA_baa24add-dad9-4df1-9a69-16ac47431800"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ic130ac71bf1e42c7b737b642085cce55_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTUtMS0xLTA_10ea0623-c177-4c51-8964-471d10a43fe8"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ia4692046f93b4663b7e83e2a8a873af5_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzEwLTctMS0xLTA_68961c02-6fbd-4e54-859e-160e6cb57f3b"
      unitRef="usd">514000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ibcf1b8f7afc644a7b9ad7768719336a8_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTEtMS0xLTA_3d44b052-5998-4c66-bc3b-94d57db0182c"
      unitRef="usd">5551000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i57f18aa010824bad8480819ba46172f0_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTMtMS0xLTA_e0fe6bef-df5a-4b39-94fc-6cc403d7aba7"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="if47ef23bd3e44c4993c4afa7d1be94c7_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTUtMS0xLTA_719a7850-fd67-466b-86db-2b2fd001637d"
      unitRef="usd">5551000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ifcedb617c87e4dcb92d2c7b639fcd223_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTctMS0xLTA_a07b59ee-3317-4bdd-8899-a11515bb56f7"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i0b5020617b024955ba56ec0766513aad_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzExLTEtMS0xLTg0ODg_83a8029c-14f9-4cf9-8750-d12aabe30faf"
      unitRef="usd">199000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i8c35be238f5f4799bbc1031e24efec68_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTMtMS0xLTA_2ca15e07-fbf9-4b27-9322-1785e6e15775"
      unitRef="usd">199000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i132a6a890ed4471ba8dcfb3ace9549a0_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTUtMS0xLTA_e5be5822-c5b6-4f95-aede-a2fc5000a76f"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i3069e6dc112c4ef2a9cf5ab7ee50048d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE0LTctMS0xLTA_84a1c286-4a45-4e13-af96-d838026b3321"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ie7d6396714744e2880bfbeacc09c78a1_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTEtMS0xLTA_8da5aefe-05c2-4094-a667-c915208c45c3"
      unitRef="usd">12741000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ib357eeae00de4b2f9b1a22317457315f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTMtMS0xLTA_91c532cb-08c7-4000-b8f1-9c35b8f0b142"
      unitRef="usd">199000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="iaec1f0cb2e8f4161bf76fddd99eb0736_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTUtMS0xLTA_18718adf-22b6-48af-9583-c09633a17c51"
      unitRef="usd">5551000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i064b2d87f1aa43ff92552e6aff6b3e54_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTpkZTY5YzA2NWNmOWU0N2E1YjNjOTRlY2FhMjNmZWY2Yy90YWJsZXJhbmdlOmRlNjljMDY1Y2Y5ZTQ3YTViM2M5NGVjYWEyM2ZlZjZjXzE1LTctMS0xLTA_6bc08190-e817-444f-983d-cc0f2b06ad67"
      unitRef="usd">6991000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ib61cc1114176418598c990b41c9592be_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtMS0xLTEtMA_ee87bffb-b725-459f-9e82-0a7ac4029d48"
      unitRef="usd">181041000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i2fe58c083e874cab83a78bcd827e2e5f_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtMy0xLTEtMA_2c6456f4-1b13-43a3-8287-813cbb9068b7"
      unitRef="usd">1896000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i1b4d2c43bec54742920bd9ad32b07e48_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtNS0xLTEtMA_ad8300c0-d67e-4f28-8ee7-2ee198e13f51"
      unitRef="usd">179145000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i30473976e3b8481aa885bb1335a889ba_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzQtNy0xLTEtMA_08a9c200-534f-4364-ace9-6e090ea393de"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i6012dd95b4ab4dde814d5a046166d09c_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtMS0xLTEtMA_d519d816-c6de-4f9a-bb63-0072047c312d"
      unitRef="usd">3877000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i1baadb28e8b3408fa30ff77e00eec512_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtMy0xLTEtMA_cd4108e8-5a17-4bcf-990b-c18ecac80e27"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i1941637101594a8cabf4ba0b5e120f5e_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtNS0xLTEtMA_639cdbae-0e7f-4d40-9516-79ef1a023d96"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="iee4b70d2241e4511bad0987b2b407f03_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzUtNy0xLTEtMA_bf8ef6d4-87b2-46c0-a273-14f288eacd8b"
      unitRef="usd">3877000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ie61370b969e74487b411b5a782a4d5a1_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtMS0xLTEtMA_2fca75a3-bdcf-4f13-9733-2b1c69761200"
      unitRef="usd">3846000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i8bfcb6d6abee4192bca4732758d746b7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtMy0xLTEtMA_c2a90a3b-17a8-4836-9564-cedba9138bb6"
      unitRef="usd">3846000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="ife3a9602a0cc4ec79c3b2bda40aa033e_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtNS0xLTEtMA_7934eed9-93df-43ea-a012-e05b9415fb91"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i62bcebfbe2964b9da317b06464c29f89_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzYtNy0xLTEtMA_4dadf3c8-1e17-41b9-b1f3-767751fd2471"
      unitRef="usd">0</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="iee6fe34449294b25881d8dbef0b24b9a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctMS0xLTEtMA_29cd49c8-12c2-4480-a425-f5d39040ccc5"
      unitRef="usd">188764000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i1c52c13365f3461ab55087c232b51f23_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctMy0xLTEtMA_21f15c36-4074-4930-84e7-66f318cd9e0a"
      unitRef="usd">5742000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i0061c212e5ce4c66940a7702790b784e_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctNS0xLTEtMA_e3b8882e-03bb-49f6-a163-787c74510d1f"
      unitRef="usd">179145000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:AssetsFairValueDisclosure
      contextRef="i570e675c9bf14c37b7f85f189f5c58ec_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzctNy0xLTEtMA_35295f68-2b60-4f4e-a57a-b4be11ee55ae"
      unitRef="usd">3877000</us-gaap:AssetsFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i2ae9df4c8cc94d689af9eb73b9a9fceb_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktMS0xLTEtMA_8f17d4dc-ac09-47ff-8264-798c6e20e7a7"
      unitRef="usd">8401000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i221c7262300e453ebd7dc80f8dc71c46_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktMy0xLTEtMA_b5d9e3dd-2e4c-45d6-a4b9-6d0e1063965e"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i63575e7ad8594216a6892afca9a80932_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktNS0xLTEtMA_ebd355e4-b516-4c89-ad34-12e042656460"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i5c6283c43ebd4c50aa4fe656936d6b4b_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzktNy0xLTEtMA_6c613d73-3c2e-4124-8307-d7b5ba48d85c"
      unitRef="usd">8401000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ia7a3efe3d1124d26b92d141e512095a0_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTEtMS0xLTA_f6ffba00-5edd-4e32-91fa-847556b0277d"
      unitRef="usd">1589000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i9bb6c8e4586348ad8838a58f65c26246_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTMtMS0xLTA_f522032f-3d2f-425a-a732-96fba30a3a6b"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i6a51c585db8547f0acb66bf4eb5290b7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTUtMS0xLTA_b0143b91-4a78-4084-a6b5-66ed689adad2"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i929b0893ee4f41fba2a2db7c8914d4f5_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEwLTctMS0xLTA_ffe5c25d-14f7-4368-8d8d-68faaf79852d"
      unitRef="usd">1589000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i0ad5f3f765e1490fa0521acd9849999d_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTEtMS0xLTg1MTA_fbe01524-9860-4368-924d-b3a93ffd1ae7"
      unitRef="usd">3971000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i73c27a6035d749d5b1f296f7edb8ca72_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTMtMS0xLTg1MTI_98a7385b-98fe-4394-99b0-27cb8c2ce432"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="ic453e34dcee74d5d9343bfeb6edf1581_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTUtMS0xLTY0ODI_7f323acf-0a70-4bb9-a5e8-0d3411c4de29"
      unitRef="usd">3971000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i9a3fec8ff6854321a38379f92429618c_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzExLTctMS0xLTg1MTY_fbb26a7d-0d70-408a-8311-d884521f3701"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i00244b874b5f4b12a47e76b73be3fabf_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTEtMS0xLTg1MTg_ac8c3b25-7257-46f9-a077-ed1db6460b3a"
      unitRef="usd">284000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i928d1de786ce437ebcfc3e3082b3f1b9_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTMtMS0xLTA_2e019586-be59-4d31-83a8-314c5faab896"
      unitRef="usd">284000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i107301a7878e4cf4938d9121959d04a0_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTUtMS0xLTA_0259c0cf-2c24-4a3b-bcd8-71f8b0f5987a"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i0d5efee5821c41c0a5ea3977d0964f60_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEyLTctMS0xLTA_468869c0-fdbd-433a-8606-1266defb4bc9"
      unitRef="usd">0</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="iee6fe34449294b25881d8dbef0b24b9a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTEtMS0xLTg1MjA_d3db051a-507c-4436-9e1c-41890a61bbab"
      unitRef="usd">14245000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i1c52c13365f3461ab55087c232b51f23_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTMtMS0xLTg1MjI_1d755b44-0bf6-4d53-be3b-5c2420b221d8"
      unitRef="usd">284000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i0061c212e5ce4c66940a7702790b784e_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTUtMS0xLTg1MjQ_528fc59d-ad1d-42a1-8a32-c806a8214f49"
      unitRef="usd">3971000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:LiabilitiesFairValueDisclosure
      contextRef="i570e675c9bf14c37b7f85f189f5c58ec_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo0YmQ2YTdhODY5ODI0MGFhYjc2NGY4NDZmMzQzYTljMS90YWJsZXJhbmdlOjRiZDZhN2E4Njk4MjQwYWFiNzY0Zjg0NmYzNDNhOWMxXzEzLTctMS0xLTg1MjY_920d5737-78a0-48cd-b948-936e7324618e"
      unitRef="usd">9990000</us-gaap:LiabilitiesFairValueDisclosure>
    <us-gaap:AlternativeInvestmentMeasurementInput
      contextRef="ifa4d91631dbf46cc83d6a025d8915d6e_I20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIwMjk_4b1d8937-1f6a-498c-b2dc-68d59a863f5f"
      unitRef="number">0.75</us-gaap:AlternativeInvestmentMeasurementInput>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyMDU_e8deb371-3063-4a35-bf3e-c165443b08b3"
      unitRef="usd">0.0</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements>
    <lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyMzg_88461889-021a-40cc-9592-588186673faa"
      unitRef="usd">-900000</lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease>
    <lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzIyNDY_c669aede-b005-4d5f-a8f5-34ec0303839e"
      unitRef="usd">-200000</lgnd:ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease>
    <us-gaap:ContractWithCustomerAssetGross
      contextRef="ib09e4721ddef410299f0bd0c417261ed_I20181231"
      decimals="-6"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ0Nw_e7684d1b-17ef-4707-b37a-2a79341a148e"
      unitRef="usd">375000000.0</us-gaap:ContractWithCustomerAssetGross>
    <us-gaap:ContractWithCustomerAssetGross
      contextRef="icd248d584f1346b5b66dd780d1e9928a_I20181231"
      decimals="-6"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ1MQ_7321d6c5-b145-4c2d-b57f-fcdc4dc6848f"
      unitRef="usd">10000000.0</us-gaap:ContractWithCustomerAssetGross>
    <us-gaap:ContractWithCustomerAssetGross
      contextRef="ice0efd7fd9d64d719b062c5b9df1406e_I20181231"
      decimals="-6"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzU0OTc1NTgyOTQ1Mw_c1bcf13b-c5b8-4b51-a210-a8951262dced"
      unitRef="usd">529000000.0</us-gaap:ContractWithCustomerAssetGross>
    <lgnd:FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90ZXh0cmVnaW9uOmE2ZjMwMzhjZTljNTQ0OWU5NDBjMWY3ODA1MGU2MDdmXzY1OTcwNjk3ODIyMDY_59aa989a-670a-4f1e-be88-831519f5a326">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of the level 3 financial instruments as of December&#160;31, 2018 is as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:45pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:81.284457%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:14.715543%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,877&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;"&gt;Cash payment received as repayment of note receivable&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,877)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instrument assets as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments to CVR holders and other contingency payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,025)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value adjustments to contingent liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,974)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of level 3 financial instruments as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</lgnd:FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzEtMS0xLTEtMA_068ed564-f195-45c8-9d4c-472fe5e3d8e4"
      unitRef="usd">3877000</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzMtMS0xLTEtMA_64833e0c-1153-4e52-b808-9de725112759"
      unitRef="usd">3877000</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzQtMS0xLTEtMA_ab877ed2-1f26-4a3d-94f2-e7181e00a806"
      unitRef="usd">0</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzctMS0xLTEtMA_53429ffe-61a3-41f2-98d6-353123fb2f2e"
      unitRef="usd">9990000</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="i921201b66b074388aa32f960d2db10cc_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzktMS0xLTEtMA_408bb3f8-3cfb-4b72-b162-bd18308028b3"
      unitRef="usd">1025000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="ice45c867198c4943b2d8c9ed9f84c1df_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzEwLTEtMS0xLTA_92a59a91-f2a2-4517-9d27-6b7d0ed698d9"
      unitRef="usd">-1974000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MDgvZnJhZzphNmYzMDM4Y2U5YzU0NDllOTQwYzFmNzgwNTBlNjA3Zi90YWJsZTo2NDY4YmQ0NzU4NWE0ZDgzOGRmMWMwMDE0Y2RiMTAyMS90YWJsZXJhbmdlOjY0NjhiZDQ3NTg1YTRkODM4ZGYxYzAwMTRjZGIxMDIxXzExLTEtMS0xLTA_a79fd5c3-55fa-4b5f-8c99-899359881d5e"
      unitRef="usd">6991000</us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue>
    <us-gaap:LeasesOfLesseeDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzk4OTU2MDQ2NTA2NDU_24173a19-1202-4ff0-8df7-b5392e64f34f">Lease Obligations&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We lease office facilities&#160;under various operating leases. These leases expire between 2019 and 2023. Total rent expense, net under all office leases for 2018, 2017 and 2016 was $1.0 million, $0.3 million and $0.3 million, respectively.  The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of December&#160;31, 2018 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:39.679627%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.577605%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.975117%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.577605%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.975117%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.044168%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.797823%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.044168%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.108865%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.733126%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.486781%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Operating lease obligations:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Lease&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Termination&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Date&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Less than 1&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;year&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1-2 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3-4 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Corporate headquarters - San Diego, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;April 2023&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;135&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;283&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;616&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office and research facility - La Jolla, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;June 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;373&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;373&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Bioscience and Technology Business Center - Lawrence, KS&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 2020&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;57&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;113&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office - Emeryville, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;August 2021&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;260&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;455&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;715&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research Facility  - Emeryville, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;August 2021&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;203&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;351&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;554&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office - Winnersh, United Kingdom&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;April 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research Facility  - Cambridge, United Kingdom&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;September 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;549&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;549&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating lease obligations&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,620&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,963&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Sublease payments expected to be received:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office and research facility - La Jolla, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;June 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;360&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;360&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net operating lease obligations&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,260&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,603&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:LeasesOfLesseeDisclosureTextBlock>
    <us-gaap:LeaseAndRentalExpense
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIwMg_7e6775ef-8ea0-44f7-8909-cea63d218403"
      unitRef="usd">1000000.0</us-gaap:LeaseAndRentalExpense>
    <us-gaap:LeaseAndRentalExpense
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIwNg_15f9936c-2d96-484e-9649-0785155fa4d8"
      unitRef="usd">300000</us-gaap:LeaseAndRentalExpense>
    <us-gaap:LeaseAndRentalExpense
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzIxMw_ff456935-0846-4ce2-86b6-79b42e149d44"
      unitRef="usd">300000</us-gaap:LeaseAndRentalExpense>
    <us-gaap:ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90ZXh0cmVnaW9uOjEyZjIwNDAzNDUzNDQzMTM4MWNkZDE2OGMzNzc4YTMyXzk4OTU2MDQ2NTA2NDY_d524c674-c821-4cd5-8dac-b63363f8acc3">The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of December&#160;31, 2018 (in thousands):&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:39.679627%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.577605%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.975117%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.577605%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.975117%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.044168%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.797823%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.044168%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.108865%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.733126%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.486781%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Operating lease obligations:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Lease&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Termination&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Date&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Less than 1&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;year&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1-2 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3-4 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Corporate headquarters - San Diego, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;April 2023&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;135&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;283&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;616&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office and research facility - La Jolla, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;June 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;373&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;373&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Bioscience and Technology Business Center - Lawrence, KS&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 2020&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;57&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;113&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office - Emeryville, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;August 2021&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;260&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;455&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;715&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research Facility  - Emeryville, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;August 2021&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;203&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;351&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;554&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office - Winnersh, United Kingdom&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;April 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research Facility  - Cambridge, United Kingdom&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;September 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;549&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;549&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating lease obligations&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,620&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,963&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Sublease payments expected to be received:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Office and research facility - La Jolla, CA&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;June 2019&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;360&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;360&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net operating lease obligations&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,260&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,145&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;198&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,603&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;</us-gaap:ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtNC0xLTEtMA_a50cf5be-db9f-47da-a4fa-d4e815c8c880"
      unitRef="usd">135000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears
      contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtNi0xLTEtMA_4b57dcd5-9b30-48c5-bed4-01ffb02326f8"
      unitRef="usd">283000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears
      contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtOC0xLTEtMA_1f5a031a-11ba-418f-9e85-490fde759093"
      unitRef="usd">198000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i90f8a9db2c664665a84b2f5fadf055a6_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEtMTItMS0xLTA_f6c4ee54-d14c-4cf2-912d-10b3e2d745ca"
      unitRef="usd">616000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItNC0xLTEtMA_0fc2be39-55bf-4bdb-808b-2273ae6e12d5"
      unitRef="usd">373000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItOC0xLTEtMA_0bc70ceb-d0a5-4a56-ad56-540e8f8673bd"
      unitRef="usd">0</lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzItMTItMS0xLTA_882fef1b-7735-4e70-b393-d48a62119913"
      unitRef="usd">373000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtNC0xLTEtMA_1021fc1c-6ddb-4957-afb2-8c3de16fd408"
      unitRef="usd">57000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears
      contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtNi0xLTEtMA_3a5d2e8b-403e-42a8-8303-f5864ba9d859"
      unitRef="usd">56000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i883212435cba47509b8b8d099bf0e1ca_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzMtMTItMS0xLTA_ad30661f-e0d0-4739-a216-3c64e9d4b52e"
      unitRef="usd">113000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtNC0xLTEtMA_4f0c12cf-f192-4b13-921f-21cb6ae7d1de"
      unitRef="usd">260000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears
      contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtNi0xLTEtMA_748b9109-7adc-4366-bf60-5eb07c20f72e"
      unitRef="usd">455000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="ifa49963bd5424932b50d46aad0ed712f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzQtMTItMS0xLTA_747bb786-22e2-428b-9a5e-5c64caef7fbb"
      unitRef="usd">715000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtNC0xLTEtMA_beba5cd2-d814-4a68-83f7-5c08df078576"
      unitRef="usd">203000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears
      contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtNi0xLTEtMA_e6e1645c-5c4c-4309-87ac-4d2d9fee0f4a"
      unitRef="usd">351000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i6e55f210c9ac49b5987a4861064c949d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzUtMTItMS0xLTA_79d67a69-6109-4677-8c3e-6515a462d335"
      unitRef="usd">554000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i354c535302b44bb19e10fe3b5a010cc8_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNC0xLTEtODczMA_7ace3a5d-4d51-4d81-a802-ceb6f60d8c92"
      unitRef="usd">43000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i354c535302b44bb19e10fe3b5a010cc8_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtMTItMS0xLTg3Nzc_d677dc24-9417-4f06-b2f9-0b957cc14f70"
      unitRef="usd">43000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="ic340228d81314653a2c316604b50c401_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzctNC0xLTEtODc2MQ_ec4d2e0e-f970-434c-b869-f6b15c2ab3fa"
      unitRef="usd">549000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="ic340228d81314653a2c316604b50c401_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzctMTItMS0xLTg3Nzc_dbfb3fc6-7f6b-4d4a-9d7a-1f8eed770a4e"
      unitRef="usd">549000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNC0xLTEtMA_a686b334-33c4-4f9a-b58b-36c930e1c8f3"
      unitRef="usd">1620000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtNi0xLTEtMA_d78abf02-a0a1-4830-a020-6bcf00afaf2e"
      unitRef="usd">1145000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtOC0xLTEtMA_5facbbbf-497f-4b45-9195-3c3ec0135d9f"
      unitRef="usd">198000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzYtMTItMS0xLTA_8fdc930c-7493-4271-af87-65b180a02586"
      unitRef="usd">2963000</us-gaap:OperatingLeasesFutureMinimumPaymentsDue>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktNC0xLTEtMA_46070a89-a2d8-4dc5-a8c0-92e8cba6b7d6"
      unitRef="usd">360000</lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktNi0xLTEtMA_d5aa0f0b-368c-4dd1-aac7-fb988ecfafe9"
      unitRef="usd">0</lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktOC0xLTEtMA_3c95a04d-bc0a-4db2-bdef-63510aea3269"
      unitRef="usd">0</lgnd:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears>
    <us-gaap:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals
      contextRef="i9c0a19e6fade4506a5851714e59f5e3e_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzktMTItMS0xLTA_ba8cda3a-4cac-40fd-99bb-560ad1bf7055"
      unitRef="usd">360000</us-gaap:OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTQtMS0xLTA_1aace4de-47ed-4fae-b42d-1c54662cd2ba"
      unitRef="usd">1260000</lgnd:OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTYtMS0xLTA_9dd62981-cdb9-4829-b0de-adf884e4b39c"
      unitRef="usd">1145000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTgtMS0xLTA_d5ad5192-a861-408e-8dba-a776f61d9799"
      unitRef="usd">198000</lgnd:OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet>
    <lgnd:OperatingLeasesFutureMinimumPaymentsDueNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MjAvZnJhZzoxMmYyMDQwMzQ1MzQ0MzEzODFjZGQxNjhjMzc3OGEzMi90YWJsZTplMTQ5MDU5NzdiZjg0ZjgzYWEzMjU4OTUzM2M3NjdkMS90YWJsZXJhbmdlOmUxNDkwNTk3N2JmODRmODNhYTMyNTg5NTMzYzc2N2QxXzEwLTEyLTEtMS0w_5cb166be-eec4-4dac-9781-d5c0814d3a76"
      unitRef="usd">2603000</lgnd:OperatingLeasesFutureMinimumPaymentsDueNet>
    <us-gaap:DebtDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzkzNDU4NDg4NzAyMDE_c1594a84-1ec2-4363-becb-b91941ddb6d7">Convertible Senior Notes&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;0.75% Convertible Senior Notes&#160;due 2019&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In August 2014, we issued $245.0 million aggregate principal amount of 2019&#160;Notes, resulting in net proceeds of $239.3 million. The implied estimated effective rate of the liability component of the 2019 Notes was 5.83%.&#160;The 2019 Notes are convertible into common stock at an initial conversion rate of 13.3251 shares per $1,000 principal amount of convertible notes, subject to adjustment upon certain events, which is equivalent to an initial conversion price of approximately $75.05 per share of common stock. The notes bear cash interest at a rate of 0.75% per year, payable semi-annually. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Holders of the 2019 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding May 15, 2019, under any of the following circumstances: &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(1) during any fiscal quarter (and only during such fiscal quarter) commencing after December&#160;31, 2014, if,&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;for at least 20 trading days (whether or not consecutive) during the&#160;30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than 130% of the conversion price on such trading day; &lt;/span&gt;&lt;/div&gt;&lt;div style="padding-left:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(2) during the five business day period immediately following any&#160;10 consecutive trading day period, in which the trading price per $1,000 principal amount of notes was less than 98% of the product of the last reported sale price of our common stock on such trading day and the conversion rate on each such trading day; or &lt;/span&gt;&lt;/div&gt;&lt;div style="padding-left:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="padding-left:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes. &lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December 31, 2017, our last reported sale price of our common stock exceeded the 130% threshold described above and accordingly&#160;the 2019&#160;Notes were classified as a current liability. As a result, the related unamortized&#160;discount of $18.9 million&#160;at December 31, 2017, was classified as temporary equity component&#160;of currently redeemable convertible notes on our consolidated balance sheet.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December 31, 2018, our 2019 Notes are due in less than one year, and accordingly have been&#160;classified as a current liability. Under the original indenture conversion, we were obligated to deliver cash to settle the principal and may&#160;deliver cash or shares of common stock, at our option, to settle any premium due upon conversion for any conversion notices received prior&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt; to May 22, 2018. We made an irrevocable election to settle the entire&#160;note in cash&#160;per&#160;a supplemental indenture entered into on May 22, 2018. As such, we must deliver cash to settle the principal and any premium due upon conversion for any conversion notices&#160;received on or after May 22, 2018.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As a result of the requirement to deliver cash to settle any premium due upon conversion, on May 22, 2018, we reclassified from equity to liability the conversion option (a derivative) fair value of $341.6 million. In accordance with ASC 815, Derivatives and Hedging, the derivative was adjusted to its fair value as of December 31, 2018 to $23.4 million with the resulting $118.7 million increase, net of payments made, reflected in other expense, net, in our consolidated statements of operations for the year ended December 31, 2018.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:10pt;line-height:115%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In March and April 2018, we received notices for conversion of $21.8 million of principal amount of the 2019 Notes which were settled in&#160;May and June 2018. We paid the noteholders the conversion value of the notes in cash, up to the principal amount of the 2019 Notes. The&#160;excess of the conversion value over the principal amount, totaling&#160;$31.6 million, was paid in shares of common stock.&#160;In July and&#160;August 2018, we received notices for conversion of&#160;$195.9 million&#160;of principal amount of the 2019 Notes which were settled in October and November 2018. We paid the noteholders the&#160;$195.9 million&#160;principal amount and the excess of&#160;conversion value over the principal amount, totaling&#160;$439.6 million, in cash. The equity dilution and&#160;cash conversion premium payment&#160;upon conversion of the 2019 Notes was offset by the reacquisition of the shares and cash under the convertible bond hedge transactions entered into in connection with the offering of the 2019 Notes.&#160;As a result of the conversions, we recorded a&#160;$3.2 million loss on extinguishment of debt calculated as the difference between the estimated fair value of the debt and the carrying value of the 2019 Notes as of the settlement dates. To measure the fair value of the converted 2019 Notes as of the settlement dates, the applicable interest rates were estimated using Level 2 observable inputs and applied to the converted notes using the same methodology as in the issuance date valuation.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Convertible Bond Hedge and Warrant Transactions&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In August 2014, to minimize the impact of potential dilution to our common stock upon conversion of the 2019 Notes, we entered into convertible bond hedges and sold warrants covering 3,264,643 shares of our common stock. The convertible bond hedges have an exercise price of $75.05 per share and are exercisable when and if the 2019 Notes are converted. If upon conversion of the 2019 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into by us and are not part of the terms of the 2019 Notes. Holders of the 2019 Notes and warrants will not have any rights with respect to the convertible bond hedges. We paid $48.1 million for these convertible bond hedges and recorded the amount as a reduction to additional paid-in capital.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Conversion notices received after May 22, 2018 relating to the 2019 Notes must be fully settled in cash and amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the convertible bond hedge. As a result of the irrevocable cash election, on&#160;May 22, 2018, we reclassified from equity to derivative asset the remaining bond hedge fair value of&#160;$340.0 million and marked it to&#160;market as of December 31, 2018 to&#160;$22.6 million with the resulting $119.4 million&#160;increase, net of $471.2 million in payments received, reflected in other expense,&#160;net, in our consolidated statements of operations for the year ended December 31, 2018.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants to acquire&#160;3,264,643 shares of common stock with an exercise price of&#160;$125.08 per share, subject to certain adjustments.&#160;The warrants have various expiration dates ranging from November 13, 2019 to April 22, 2020. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise price of the warrants, as measured under the terms of the warrant transactions. We received $11.6 million for these warrants and recorded this amount to additional paid-in capital. The common stock issuable upon exercise of the warrants will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC registering the issuance of the shares under the warrants.&#160;We continue to have the ability to avoid&#160;settling the warrants associated with the 2019 Notes in cash after May 22, 2018.&#160;Accordingly, the warrants continue to be classified in&#160;additional paid in capital.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In November 2018, we modified agreements with one of the bond hedge counterparties to cash settle a total of 525,000&#160;warrants. As the modifications required the warrants to be cash settled, the fair value of the warrants was reclassified from stockholders&#x2019; equity to a derivative liability on the modification dates, resulting in a $28.3 million deduction to additional paid-in-capital during 2018. We settled these repurchases for total consideration of $30.1 million and recorded a&#160;$1.8 million loss during 2018 on the change in the fair value of the derivative liabilities between their modification and settlement dates, which is included in other&#160;expense, net in the accompanying consolidated statement of operations. As a result, as of December 31, 2018,&#160;2,739,643 warrants remain outstanding.  &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;0.75% Convertible Senior Notes due 2023&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In May 2018, we issued $750 million aggregate principal amount of 2023 Notes, bearing cash interest at a rate of&#160;0.75%&#160;per year, payable semi-annually. The net proceeds from the offering,&#160;after deducting the initial purchasers' discount and offering expenses, were approximately $733.1 million. The 2023 Notes will be&#160;convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on an initial&#160;conversion rate, subject to adjustment, of 4.0244 shares per $1,000 principal amount of the 2023 Notes which represents an initial&#160;conversion price of approximately $248.48 per share.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Holders of the 2023 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding&#160;November 15, 2022, under any of the following circumstances:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(1) during any fiscal quarter (and only during such fiscal quarter) commencing after September 30, 2018, if, for at least&#160;20&#160;trading&#160;days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately&#160;preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than&#160;130% of the&#160;conversion price on such trading day;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(2) during the&#160;five business day period immediately following any&#160;10 consecutive trading day period, in which the trading price per&#160;$1,000 principal amount of notes was less than&#160;98% of the product of the last reported sale price of our common stock on such&#160;trading day and the conversion rate on each such trading day; or&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;At the May 22, 2018 issuance date of the 2023 Notes, we did not have the necessary number of authorized but unissued shares of&#160;our common stock available to settle the conversion option of the 2023 Notes in shares. Therefore, in accordance with guidance found in ASC&#160;815-15 &#x2013; Embedded Derivatives, the conversion option of the Notes was deemed an embedded derivative requiring bifurcation from the&#160;2023 Notes (host contract) and separate accounting as a derivative liability. The fair value of the conversion option derivative liability at&#160;May 22, 2018 was $144.0 million, which was recorded as a reduction to the carrying value of the debt. This debt discount is amortized to&#160;interest expense over the term of the debt using the effective interest method. Up to the date in which we received shareholder approval on&#160;June 19, 2018 to increase the authorized number of shares of our common stock, the conversion option was accounted for as a liability with&#160;the resulting change in fair value of $13.5 million during that period reflected in other expense, net, in our consolidated&#160;statements of operations for the year ended December 31, 2018. As of December 31, 2018, the debt discount remains and&#160;continues to be amortized to interest expense.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The notes will have a dilutive effect to the extent the average market price per share of common stock for a given reporting period exceeds&#160;the conversion price of $248.48. As of December 31, 2018, the &#x201c;if-converted value&#x201d; did not exceed the principal amount of the 2023&#160;Notes.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with the issuance of the 2023 Notes, we incurred $16.9 million of issuance costs, which primarily consisted of underwriting,&#160;legal and other professional fees. The portion of these costs allocated to the conversion option totaling&#160;$3.2 million was recorded as interest&#160;expense for the twelve months ended&#160;December&#160;31, 2018. The portion of these costs allocated to the liability component totaling&#160;$13.7 million is amortized to interest expense using the effective interest method over the five year expected life of the 2023 Notes.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the&#160;principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Convertible Bond Hedge and Warrant Transactions&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In conjunction with the 2023 Notes, in May 2018, we entered into convertible bond hedges and sold warrants covering 3,018,327 shares of&#160;our common stock to minimize the impact of potential dilution to our common stock and/or offset the cash payments we are required to&#160;make in excess of the principal amount upon conversion of the 2023 Notes. The convertible bond hedges have an exercise price of $248.48&#160;per share and are exercisable when and if the 2023 Notes are converted. We paid&#160;$140.3 million for these convertible bond hedges. If upon&#160;conversion of the 2023 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties&#160;will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of&#160;common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible&#160;bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into&#160;by us and are not part of the terms of the 2023 Notes. Holders of the 2023 Notes and warrants will not have any rights with respect to the&#160;convertible bond hedges.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants covering&#160;3,018,327 shares of common stock with an exercise price of $315.38 per share, subject to certain adjustments.&#160;We received $90.0 million for these warrants. The warrants have various expiration dates ranging from August 15, 2023 to February 6,&#160;2024. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise&#160;price of the warrants, as measured under the terms of the warrant transactions. The common stock issuable upon exercise of the warrants&#160;will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC&#160;registering the issuance of the shares under the warrants.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;For the period from May 22, 2018, the issuance date of the bond hedge and warrant transactions, to June 19, 2018, the date shareholders&#160;approved an increase in our authorized shares of common stock, the bond hedges and warrants required cash settlement and were accounted&#160;for as a derivative asset and liability, respectively, with the resulting increase in fair value of $19.2 million&#160;and $7.5 million&#160;reflected in other expense, net, in our consolidated statements of operations for twelve months ended&#160;December&#160;31, 2018.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes information about the equity and liability components of the 2019 Notes and 2023 Notes (in thousands).&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:57.970674%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:16.768328%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:2.292669%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:16.768328%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Principle amount of 2019 Notes outstanding&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,326&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;245,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Unamortized discount (including unamortized debt issuance cost)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(893)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(20,471)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total current portion of notes payable&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,433&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;224,529&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Principle amount of 2023 Notes outstanding&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;750,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Unamortized discount (including unamortized debt issuance cost)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(140,136)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total long-term portion of notes payable&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;609,864&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Carrying value of equity component of 2023 Notes&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;127,997&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of convertible senior notes outstanding (Level 2)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;713,533&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;446,360&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December&#160;31, 2018, there were no events of default or violation of any covenants under our financing obligations.&lt;/span&gt;&lt;/div&gt;</us-gaap:DebtDisclosureTextBlock>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEwMQ_530ba52d-a39f-44f7-8e97-c611a0808ec0"
      unitRef="usd">245000000.0</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:ProceedsFromDebtNetOfIssuanceCosts
      contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzE5OA_47a03c04-0bc2-4097-af95-30e3486e67b1"
      unitRef="usd">239300000</us-gaap:ProceedsFromDebtNetOfIssuanceCosts>
    <us-gaap:DebtInstrumentInterestRateEffectivePercentage
      contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831"
      decimals="4"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ3Mg_3eaada82-03e8-488b-96b4-b24848a6850d"
      unitRef="number">0.0583</us-gaap:DebtInstrumentInterestRateEffectivePercentage>
    <us-gaap:DebtInstrumentConvertibleConversionPrice1
      contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzQ3NQ_3aa6ca5a-7a4e-4bd7-96f2-814d76472a96"
      unitRef="usdPerShare">75.05</us-gaap:DebtInstrumentConvertibleConversionPrice1>
    <us-gaap:DebtInstrumentInterestRateStatedPercentage
      contextRef="ibd4aa0b2117641deace84f081e7d99ce_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OA_eb037d8f-121c-491e-a306-b742c2373986"
      unitRef="number">0.0075</us-gaap:DebtInstrumentInterestRateStatedPercentage>
    <us-gaap:DebtInstrumentConvertibleThresholdTradingDays
      contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzkyMg_6485fcb7-bbcd-4a27-af04-217533f475ad"
      unitRef="trading_day">20</us-gaap:DebtInstrumentConvertibleThresholdTradingDays>
    <us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
      contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzk4MA_78a0e30e-59c5-4882-a5a5-b8eb74491894"
      unitRef="trading_day">30</us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1>
    <us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger
      contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzExODU_d9da2c52-977c-482f-917d-1220c7b7b192"
      unitRef="number">1.30</us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger>
    <us-gaap:DebtInstrumentConvertibleThresholdTradingDays
      contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEyNTI_f1cba4ce-b10a-4edb-b773-22ead3ad5a6f"
      unitRef="day">5</us-gaap:DebtInstrumentConvertibleThresholdTradingDays>
    <us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
      contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzEzMDM_ca7e96f2-441f-48b2-a17a-d111e8424380"
      unitRef="trading_day">10</us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1>
    <lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger
      contextRef="i37d8bbb06fcc43ad8a574ace97dab1d8_D20140801-20140831"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzE0MTY_1f1dcf3c-38da-444a-93db-874f48d46d8d"
      unitRef="number">0.98</lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger>
    <us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger
      contextRef="ia848394235d34b9fa458e689d387fe2f_D20140801-20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzYwNDczMTM5OTQwMTU_156b74eb-460a-4655-a664-486c186dac4b"
      unitRef="number">1.30</us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger>
    <us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzYwNDczMTM5OTQwMzU_d6d512a4-e688-494d-9a84-2da60f071861"
      unitRef="usd">18900000</us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent>
    <us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal
      contextRef="ic6a1014c54c4494f865d0272345aab6a_D20180522-20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTM5Njk_cefd2382-9fbb-4cd3-be66-07908d5f7e22"
      unitRef="usd">341600000</us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal>
    <us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal
      contextRef="i69c23a1e2fbe4523a3ca4deec08a3872_D20181231-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTQwOTk_b1cfd10d-d00e-4ca4-9166-603bcebfa801"
      unitRef="usd">23400000</us-gaap:DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal>
    <lgnd:DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal
      contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTQxMjE_b1dad315-4370-4abc-9734-9981db2aaf0d"
      unitRef="usd">118700000</lgnd:DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal>
    <us-gaap:DebtConversionConvertedInstrumentAmount1
      contextRef="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ0NQ_6c5c3d53-fa5f-4ba9-b85e-e6e892a1ee35"
      unitRef="usd">21800000</us-gaap:DebtConversionConvertedInstrumentAmount1>
    <us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature
      contextRef="i9d0c651781784df788eaf487c644b4e6_D20180301-20180430"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ0OQ_c31eb8df-3908-483f-a026-83394652444a"
      unitRef="usd">31600000</us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature>
    <us-gaap:DebtConversionConvertedInstrumentAmount1
      contextRef="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1Mg_8a277d54-0e61-448c-bc78-8f17964face6"
      unitRef="usd">195900000</us-gaap:DebtConversionConvertedInstrumentAmount1>
    <us-gaap:DebtConversionConvertedInstrumentAmount1
      contextRef="i68c607180e5040899a6e87ab5ab10d1a_D20180701-20180831"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1NA_fec3ea8c-12a9-4f07-9a09-8cb75ecded73"
      unitRef="usd">195900000</us-gaap:DebtConversionConvertedInstrumentAmount1>
    <us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature
      contextRef="i75f0350fef6541038e98f82afd43a2f1_D20181001-20181130"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ1Nw_e919eb6c-8aa5-486e-9933-f19b5c3033c7"
      unitRef="usd">439600000</us-gaap:DebtInstrumentConvertibleBeneficialConversionFeature>
    <us-gaap:GainsLossesOnExtinguishmentOfDebt
      contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQ2MQ_38fe1290-4cd2-4243-ba68-de45c334d4ab"
      unitRef="usd">-3200000</us-gaap:GainsLossesOnExtinguishmentOfDebt>
    <us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
      contextRef="i37074bf992d247a491292198d0359ff0_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzY1MTk_04bf2962-2853-4d5b-8c91-4100db496405"
      unitRef="shares">3264643</us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
    <lgnd:ExercisePriceofConvertibleBondHedge
      contextRef="i37074bf992d247a491292198d0359ff0_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzY2MDU_a680d519-d8cf-408d-a8f0-f6eafc957d83"
      unitRef="usdPerShare">75.05</lgnd:ExercisePriceofConvertibleBondHedge>
    <lgnd:PaymentsforConvertibleBondHedges
      contextRef="i10f8c4b4ba35499abc6b570f3a196b1b_D20140801-20140831"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc1MTI_3f15e41b-fe6d-41e7-9070-b4eb6f6ac2ba"
      unitRef="usd">48100000</lgnd:PaymentsforConvertibleBondHedges>
    <us-gaap:DerivativeAssetsCurrent
      contextRef="id76a5bf7cb944f28a34fcb8257fa1d39_I20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzNA_98dfdbd2-b476-473f-bfad-4f4f05c5e6f0"
      unitRef="usd">340000000.0</us-gaap:DerivativeAssetsCurrent>
    <us-gaap:DerivativeAssetsCurrent
      contextRef="i788db1d002a24118902ba114a1c848a8_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzNw_df39abc4-6cfe-479e-ad24-9067925f22f9"
      unitRef="usd">22600000</us-gaap:DerivativeAssetsCurrent>
    <us-gaap:DerivativeGainLossOnDerivativeNet
      contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzOQ_4229494a-9b09-47de-b9be-4fa43a26f7f5"
      unitRef="usd">119400000</us-gaap:DerivativeGainLossOnDerivativeNet>
    <us-gaap:ProceedsFromDerivativeInstrumentInvestingActivities
      contextRef="ib641709bbf334da4a8f4a039bdb91244_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzcxNDY4MjU2MTk3NjQ_45454035-e1a4-4b92-b65f-f01eb88f0653"
      unitRef="usd">471200000</us-gaap:ProceedsFromDerivativeInstrumentInvestingActivities>
    <us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
      contextRef="i37074bf992d247a491292198d0359ff0_I20140831"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc3Nzc_2455029d-8ff1-4b46-a039-79b3a25218d8"
      unitRef="shares">3264643</us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
    <us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
      contextRef="i37074bf992d247a491292198d0359ff0_I20140831"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzc4NDM_5101d0d3-b051-4fe4-880d-1817bc2bfee1"
      unitRef="usdPerShare">125.08</us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued
      contextRef="i98d8d53ba8784c41bea403e9d3429ff2_D20140801-20140831"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzgyODM_b5a0d2bc-0aee-4b0f-ab91-14681891f42c"
      unitRef="usd">11600000</us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued>
    <lgnd:WarrantsSettled
      contextRef="icf42ad343571467faece802b998bf88c_D20181101-20181130"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3Mw_d26f496e-73b2-4d0f-a28b-627959b37d6e"
      unitRef="shares">525000</lgnd:WarrantsSettled>
    <lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsSettled
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3Ng_27f1dd40-bfda-42e4-9c8c-7a9fc4b3bfb7"
      unitRef="usd">28300000</lgnd:AdjustmentsToAdditionalPaidInCapitalWarrantsSettled>
    <us-gaap:PaymentsForRepurchaseOfWarrants
      contextRef="icf42ad343571467faece802b998bf88c_D20181101-20181130"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3OQ_826b3b70-b5a5-457b-9e39-140091090e3a"
      unitRef="usd">30100000</us-gaap:PaymentsForRepurchaseOfWarrants>
    <us-gaap:DerivativeGainLossOnDerivativeNet
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4Mw_bd55f176-2d14-4c59-ab89-665d00f0cfa6"
      unitRef="usd">-1800000</us-gaap:DerivativeGainLossOnDerivativeNet>
    <us-gaap:ClassOfWarrantOrRightOutstanding
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4NQ_fb55d21a-218f-4b28-aa48-ae7bd14d888f"
      unitRef="shares">2739643</us-gaap:ClassOfWarrantOrRightOutstanding>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM4OA_08c9e49e-626c-47e0-97fa-e0f98f984148"
      unitRef="usd">750000000</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentInterestRateStatedPercentage
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5MQ_3268bd4c-0666-447e-8a03-71c25cf60728"
      unitRef="number">0.0075</us-gaap:DebtInstrumentInterestRateStatedPercentage>
    <us-gaap:ProceedsFromDebtNetOfIssuanceCosts
      contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5NA_4741c875-75d2-4978-8064-72ccc2dccd44"
      unitRef="usd">733100000</us-gaap:ProceedsFromDebtNetOfIssuanceCosts>
    <us-gaap:DebtInstrumentConvertibleConversionPrice1
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM5Nw_5b860348-60e9-4990-89ef-a634bb6cc6e1"
      unitRef="usdPerShare">248.48</us-gaap:DebtInstrumentConvertibleConversionPrice1>
    <us-gaap:DebtInstrumentConvertibleThresholdTradingDays
      contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg1MzQ4MA_24cf6a91-03d7-4949-a54f-169434b0049c"
      unitRef="trading_day">20</us-gaap:DebtInstrumentConvertibleThresholdTradingDays>
    <us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
      contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwMA_4e09cacc-83ad-4334-b0dc-be5bf1065ae8"
      unitRef="trading_day">30</us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1>
    <us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger
      contextRef="ib15330d6e221404fbf8220df67ae8ebe_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwNA_cc9b9699-5e5d-4fde-9eff-c6c11540c35b"
      unitRef="number">1.30</us-gaap:DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger>
    <us-gaap:DebtInstrumentConvertibleThresholdTradingDays
      contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQwNw_57970241-4480-4d9b-a1a0-a53e9aa0bc01"
      unitRef="trading_day">5</us-gaap:DebtInstrumentConvertibleThresholdTradingDays>
    <us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1
      contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxMA_6ed96257-12a8-430d-b267-987fc35d9633"
      unitRef="trading_day">10</us-gaap:DebtInstrumentConvertibleThresholdConsecutiveTradingDays1>
    <lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger
      contextRef="i3d3c581bc3e34f979b359711fb34c894_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxMw_019df2e9-bdb5-4dff-9e10-96cbc8dc6bbc"
      unitRef="number">0.98</lgnd:DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger>
    <us-gaap:EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxNQ_f929c79b-9738-4ecc-9424-ae24cd2b3e78"
      unitRef="usd">144000000.0</us-gaap:EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability>
    <us-gaap:IncreaseDecreaseInDerivativeLiabilities
      contextRef="i978ee51a08364e3eb7649d6141d3c780_D20180522-20180619"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQxOA_e1a609e3-7395-4a65-86d8-f976cf9fda13"
      unitRef="usd">13500000</us-gaap:IncreaseDecreaseInDerivativeLiabilities>
    <us-gaap:DebtInstrumentConvertibleConversionPrice1
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyMQ_08e718c9-df60-4d9d-b180-efe636de2a74"
      unitRef="usdPerShare">248.48</us-gaap:DebtInstrumentConvertibleConversionPrice1>
    <us-gaap:DeferredFinanceCostsGross
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyNA_407683db-0487-4d9d-b3ea-bb3a3472f94e"
      unitRef="usd">16900000</us-gaap:DeferredFinanceCostsGross>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt
      contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQyOA_a1e23b2f-09de-4066-9d98-164b1a63efc7"
      unitRef="usd">3200000</us-gaap:AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt>
    <us-gaap:DebtInstrumentUnamortizedPremium
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzQzMQ_893384ba-b788-4922-b7b6-50ebd3ff7825"
      unitRef="usd">13700000</us-gaap:DebtInstrumentUnamortizedPremium>
    <us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1Mg_0edb4f45-03db-4f86-8d4b-064051dc0ead"
      unitRef="shares">3018327</us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
    <us-gaap:DebtInstrumentConvertibleConversionPrice1
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1NQ_db0fb9a1-f6a2-4320-b25f-16a03b271ff9"
      unitRef="usdPerShare">248.48</us-gaap:DebtInstrumentConvertibleConversionPrice1>
    <lgnd:PaymentsforConvertibleBondHedges
      contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM1OQ_88d8bab4-98fb-416d-b154-9196471e5b9d"
      unitRef="usd">140300000</lgnd:PaymentsforConvertibleBondHedges>
    <us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2MQ_e53d95ba-329b-4592-8166-3dfcd78b67e3"
      unitRef="shares">3018327</us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights>
    <us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
      contextRef="i970ccee7a80949d687b85a9d2bf7e349_I20180522"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2NQ_c6e76e46-2a66-45fc-96de-1dc55a41439c"
      unitRef="usdPerShare">315.38</us-gaap:ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1>
    <us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued
      contextRef="i52da0c2b4da84fbaa74e65bd6b8dee26_D20180522-20180522"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM2Nw_c671cf98-3ba7-44a1-a314-804c9a86e794"
      unitRef="usd">90000000.0</us-gaap:AdjustmentsToAdditionalPaidInCapitalWarrantIssued>
    <us-gaap:IncreaseDecreaseInDerivativeAssets
      contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzIxOTkwMjMyOTY5ODY_a8a06594-efce-43ac-98b0-02352169397f"
      unitRef="usd">19200000</us-gaap:IncreaseDecreaseInDerivativeAssets>
    <us-gaap:IncreaseDecreaseInDerivativeLiabilities
      contextRef="i827c791bf01745d9821130e71b83b5f8_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3XzU0OTc1NTg0NzM3MA_3e2e7552-6d26-42ee-9c36-5516e976a4f0"
      unitRef="usd">7500000</us-gaap:IncreaseDecreaseInDerivativeLiabilities>
    <us-gaap:ScheduleOfDebtTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90ZXh0cmVnaW9uOjZiYjNmMDA1MTg2MzQzYjY4MTI3MmZlNGUzZTA2MTg3Xzk4OTU2MDQ2ODM0Mzc_300dcb45-02f8-4093-a18c-8aac9dfcf0cc">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes information about the equity and liability components of the 2019 Notes and 2023 Notes (in thousands).&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:57.970674%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:16.768328%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:2.292669%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:16.768328%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Principle amount of 2019 Notes outstanding&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,326&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;245,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Unamortized discount (including unamortized debt issuance cost)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(893)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(20,471)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total current portion of notes payable&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,433&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;224,529&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Principle amount of 2023 Notes outstanding&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;750,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Unamortized discount (including unamortized debt issuance cost)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(140,136)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total long-term portion of notes payable&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;609,864&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Carrying value of equity component of 2023 Notes&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;127,997&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair value of convertible senior notes outstanding (Level 2)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;713,533&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;446,360&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfDebtTableTextBlock>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="i788db1d002a24118902ba114a1c848a8_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzEtMS0xLTEtMjQyNA_38fc57ea-22f5-4ea5-8bcb-1c2eb3abad2b"
      unitRef="usd">27326000</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="i8517c8b0243e45e096978d0ca26893b0_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzEtMy0xLTEtMjM5OA_b6a02e1f-820e-48d9-9911-2c497bd47d15"
      unitRef="usd">245000000</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentUnamortizedDiscount
      contextRef="i788db1d002a24118902ba114a1c848a8_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzItMS0xLTEtMA_a43fff74-1a8d-4742-b35c-dfd509e4c80e"
      unitRef="usd">893000</us-gaap:DebtInstrumentUnamortizedDiscount>
    <us-gaap:DebtInstrumentUnamortizedDiscount
      contextRef="i8517c8b0243e45e096978d0ca26893b0_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzItMy0xLTEtMA_5b637ee6-6e9c-4df3-b39e-7512d8a60269"
      unitRef="usd">20471000</us-gaap:DebtInstrumentUnamortizedDiscount>
    <us-gaap:NotesPayableCurrent
      contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzQtMS0xLTEtMA_4dfba632-8a00-4700-97b6-0fafee2958a6"
      unitRef="usd">26433000</us-gaap:NotesPayableCurrent>
    <us-gaap:NotesPayableCurrent
      contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzQtMy0xLTEtMA_d11d6c53-6512-4f8c-a41b-213b68dd32b0"
      unitRef="usd">224529000</us-gaap:NotesPayableCurrent>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzUtMS0xLTEtMjQ2Mw_dd2c5a84-2c66-4dc5-8e8c-b4b3baafc34d"
      unitRef="usd">750000000</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentFaceAmount
      contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzUtMy0xLTEtODcwMA_14294591-f40d-4d1f-bb15-b27327b438ee"
      unitRef="usd">0</us-gaap:DebtInstrumentFaceAmount>
    <us-gaap:DebtInstrumentUnamortizedDiscount
      contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzYtMS0xLTEtMjQ2Ng_999d1bb7-c616-48b3-a1ae-fdcb56c07104"
      unitRef="usd">140136000</us-gaap:DebtInstrumentUnamortizedDiscount>
    <us-gaap:DebtInstrumentUnamortizedDiscount
      contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzYtMy0xLTEtODY5OA_4ba8e8de-abd1-49cc-b299-4256bca4902a"
      unitRef="usd">0</us-gaap:DebtInstrumentUnamortizedDiscount>
    <us-gaap:LongTermNotesPayable
      contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzctMS0xLTEtODY5Mg_0af6a41e-7b7a-463c-9c95-8619f68881c8"
      unitRef="usd">609864000</us-gaap:LongTermNotesPayable>
    <us-gaap:LongTermNotesPayable
      contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzctMy0xLTEtODY5Ng_6197a1ef-28cd-4fb2-bb7d-ba76ac96cc8e"
      unitRef="usd">0</us-gaap:LongTermNotesPayable>
    <us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
      contextRef="ie527761fa7b14d4e8c10a419b7c96050_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzgtMS0xLTEtMjUxMA_69dcb941-5466-4972-b88b-c00cb7a900e0"
      unitRef="usd">127997000</us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent>
    <us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent
      contextRef="iff1b40e31eb94dd28c98c1b69495379f_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzgtMy0xLTEtODY5NA_d1a3ca2a-18af-4be6-a7cc-5c515825801c"
      unitRef="usd">0</us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent>
    <us-gaap:ConvertibleDebtFairValueDisclosures
      contextRef="ia32e2ae420b54b08bc61c77e24a0b664_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzktMS0xLTEtMjUxOA_f3caa687-4217-4a3a-95f6-0d320ef8a900"
      unitRef="usd">713533000</us-gaap:ConvertibleDebtFairValueDisclosures>
    <us-gaap:ConvertibleDebtFairValueDisclosures
      contextRef="i60cd2ff27aee458a876ce61408c2748a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80MzIvZnJhZzo2YmIzZjAwNTE4NjM0M2I2ODEyNzJmZTRlM2UwNjE4Ny90YWJsZTpkYWRiODc2ZDIzYjU0OWIwYmRkNmQ0NDE2N2UzZmZkYy90YWJsZXJhbmdlOmRhZGI4NzZkMjNiNTQ5YjBiZGQ2ZDQ0MTY3ZTNmZmRjXzktMy0xLTEtMjQ4OQ_4f796d07-9939-47ae-8a7f-6bfdd6018ed6"
      unitRef="usd">446360000</us-gaap:ConvertibleDebtFairValueDisclosures>
    <us-gaap:SupplementalBalanceSheetDisclosuresTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzI1Njg_e7debccb-0132-4f62-beb5-38437ed591eb">Balance Sheet Account DetailsShort-term Investments&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes the various investment categories at December&#160;31, 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:41.088235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cost&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Gross unrealized&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;gains&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Gross unrealized&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;losses&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Estimated&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;fair value&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Short-term investments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Bank deposits&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;311,066&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(29)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;311,063&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53,223&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(45)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53,179&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate equity securities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;135&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,191&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,326&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Commercial paper&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;225,731&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(76)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;225,663&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     U.S. Government bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,982&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(9)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,973&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Municipal bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,017&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,013&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;600,154&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,226&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(163)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;601,217&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Short-term investments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Bank deposits&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;80,095&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(42)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;80,059&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55,335&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(96)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55,239&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate equity securities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;207&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1689&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,896&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Commercial paper&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,933&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(20)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,913&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Agency bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     U.S. Government bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,939&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,929&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Municipal bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,028&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(13)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,015&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,528&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,695&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(182)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;181,041&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;margin-top:5pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Other current assets consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restricted cash&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking warrants&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,545&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,418&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Property and equipment is stated at cost and consists of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Lab and office equipment&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,183&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,460&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Leasehold improvements&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,418&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,917&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Computer equipment and software&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;936&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;697&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,537&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,074&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Less accumulated depreciation and amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,165)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,862)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,212&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter. Depreciation expense of $0.9 million, $0.4 million, and $0.2 million was recognized for the years ended December&#160;31, 2018, 2017, and 2016, respectively, and is included in operating expenses.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Goodwill and identifiable intangible assets consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Indefinite lived intangible assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     IPR&amp;amp;D&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,923&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;86,646&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;85,959&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Definite lived intangible assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Complete technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;235,413&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;222,900&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(35,070)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(23,301)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Trade name&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,642&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,642&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,048)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(916)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Customer relationships&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(11,744)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,264)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total goodwill and other identifiable intangible assets, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;306,439&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;314,543&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Amortization of finite lived intangible assets is computed using the straight-line method over the estimated useful life of the asset&#160;of 20 years. Amortization expense of $15.8 million, $11.3 million, and $10.6 million was recognized for the years ended December&#160;31, 2018 and&#160;2017, and 2016, respectively. Estimated amortization expense for the years ending December&#160;31, 2018 through 2023 is $13.6 million per year. For each of the years ended December&#160;31, 2018, 2017, and 2016, there was&#160;no&#160;impairment of intangible assets with finite lives.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:36pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accrued liabilities consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Compensation&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,045&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,085&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Legal&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;942&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;430&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Amounts owed to former licensees&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;428&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;396&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Royalties owed to third parties&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,025&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;954&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments due to broker for share repurchases&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,613&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Return reserve&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,590&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restructuring&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,093&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,464&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,512&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,200&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,377&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Contingent liabilities:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with the acquisition of CyDex in January 2011, we issued a series of CVRs and also assumed certain contingent liabilities. We may be required to make additional payments upon achievement of certain clinical and regulatory milestones to the CyDex shareholders and former license holders. We paid CyDex&#160;shareholders, through 2016, 20% of all&#160;CyDex-related revenue, but only to the extent that, and beginning only when,&#160;CyDex-related revenue for the year exceeds $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent, and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In connection with the acquisition of Metabasis in January 2010, we entered into four CVR agreements with Metabasis shareholders. The CVRs entitle the holders to cash payments as frequently as every six months as proceeds are received by us upon the sale or licensing of any of the Metabasis drug development programs and upon the achievement of specified milestones.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes contingent liabilities&#160;as of December 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.736842%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.265432%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.876543%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.413580%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Additions&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cydex&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(5,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(25)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,050)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;525&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Metabasis&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,900)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Crystal&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(924)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,476&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total &lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,100&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(5,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,925)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,426&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,501&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:SupplementalBalanceSheetDisclosuresTextBlock>
    <us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM1OTk_8509e45b-2a32-4f85-829b-46451978221e">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes the various investment categories at December&#160;31, 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:41.088235%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.676471%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cost&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Gross unrealized&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;gains&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Gross unrealized&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;losses&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Estimated&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;fair value&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Short-term investments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Bank deposits&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;311,066&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(29)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;311,063&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53,223&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(45)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53,179&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate equity securities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;135&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,191&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,326&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Commercial paper&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;225,731&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(76)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;225,663&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     U.S. Government bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,982&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(9)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,973&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Municipal bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,017&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,013&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;600,154&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,226&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(163)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;601,217&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Short-term investments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Bank deposits&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;80,095&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(42)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;80,059&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55,335&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(96)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55,239&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Corporate equity securities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;207&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1689&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,896&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Commercial paper&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,933&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(20)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,913&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Agency bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,991&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,990&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     U.S. Government bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,939&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,929&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Municipal bonds&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,028&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(13)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,015&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;179,528&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,695&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(182)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;181,041&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="if09401cad196425ab690698455cc8c3d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtMS0xLTEtMA_d4e75c83-3ccc-4132-a731-2df242daccf6"
      unitRef="usd">311066000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="if09401cad196425ab690698455cc8c3d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtMy0xLTEtMA_a82e30d2-57bd-497b-bd01-faa25d86c80c"
      unitRef="usd">26000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="if09401cad196425ab690698455cc8c3d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtNS0xLTEtMA_9cded3f8-6e97-45a0-8222-f88ea62e1e99"
      unitRef="usd">29000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="if09401cad196425ab690698455cc8c3d_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzMtNy0xLTEtMA_b87c2269-43a7-47d5-811a-9ce0e0d773c6"
      unitRef="usd">311063000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i68ecb47464af47feb893f53340e5806b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtMS0xLTEtMA_91f4f763-185d-4162-9327-c3473eb3d60e"
      unitRef="usd">53223000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i68ecb47464af47feb893f53340e5806b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtMy0xLTEtMA_3b182588-5829-4899-93f9-5b0ae734e1c4"
      unitRef="usd">1000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i68ecb47464af47feb893f53340e5806b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtNS0xLTEtMA_06557a01-139a-4441-93ea-efb0e69f3a32"
      unitRef="usd">45000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i68ecb47464af47feb893f53340e5806b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzQtNy0xLTEtMA_4495ea00-34c5-46f4-b08f-fd8be77c8291"
      unitRef="usd">53179000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtMS0xLTEtMA_e8b0b18f-8763-452d-aa0d-b751f5b33c3c"
      unitRef="usd">135000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtMy0xLTEtMA_454df91b-08f0-47fb-92c9-feee5ab5beb1"
      unitRef="usd">1191000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtNS0xLTEtMA_5699e679-ba9a-4d6e-b473-f35b57752807"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i873cc4ad2c4a424094af1f53ee86bf32_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzUtNy0xLTEtMA_0a22953d-e907-4f51-a009-2a869daccb6a"
      unitRef="usd">1326000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtMS0xLTEtMA_35cfc6d7-7852-488c-966d-f180eb920fd5"
      unitRef="usd">225731000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtMy0xLTEtMA_078987a9-10ac-4481-854a-cfbea720abbc"
      unitRef="usd">8000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtNS0xLTEtMA_c0cca924-e593-4dbe-904c-7bcff9f94372"
      unitRef="usd">76000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="ide49d3899c314c7a83ca6827111b97cd_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzYtNy0xLTEtMA_0548dc95-b494-4656-8c3f-222eda65ac3f"
      unitRef="usd">225663000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i40f8bac802b34bae87d73215caf27338_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtMS0xLTEtMA_6963df10-8104-4ec4-99f6-96429a46fbb7"
      unitRef="usd">7982000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i40f8bac802b34bae87d73215caf27338_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtMy0xLTEtMA_c3f3acf3-4149-42d9-abc5-e5c688c52373"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i40f8bac802b34bae87d73215caf27338_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtNS0xLTEtMA_8148f34a-ec32-4431-8902-4fc4d20fd202"
      unitRef="usd">9000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i40f8bac802b34bae87d73215caf27338_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzgtNy0xLTEtMA_d555c135-d316-4fb4-95bd-a53c883a1537"
      unitRef="usd">7973000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktMS0xLTEtMA_b1a64035-faa5-4e86-8aa6-248957ca6dec"
      unitRef="usd">2017000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktMy0xLTEtMA_08c24427-4060-46fd-87b4-4a849509a3c1"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktNS0xLTEtMA_e6c701be-4590-4c2f-8f8c-7c17eaa9641b"
      unitRef="usd">4000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="icbfd2d77cfdb42909cec6fea6491ed92_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzktNy0xLTEtMA_be1d7e08-610b-4a4d-8f6b-e21d8e17717f"
      unitRef="usd">2013000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTEtMS0xLTA_2bda60f8-400c-4350-863d-ca11229b0451"
      unitRef="usd">600154000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTMtMS0xLTA_de2e03dc-cfff-48c9-adbc-8dcee3d26f2a"
      unitRef="usd">1226000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTUtMS0xLTA_5345930a-b411-4887-a0a6-fa34f0631fba"
      unitRef="usd">163000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="ibe5aa361660c49aa9ade65790e60db3b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEwLTctMS0xLTA_43a1b85b-ca5b-4900-9de3-cd79fff42555"
      unitRef="usd">601217000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i843b12a2426b42a0a044c4840af01886_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTEtMS0xLTA_aec024db-fea7-4307-bee2-7411c4515179"
      unitRef="usd">80095000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i843b12a2426b42a0a044c4840af01886_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTMtMS0xLTA_63f30123-6553-44bf-a412-18b58fdbfe52"
      unitRef="usd">6000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i843b12a2426b42a0a044c4840af01886_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTUtMS0xLTA_58495694-f71d-4742-90ea-7ad965a62d8a"
      unitRef="usd">42000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i843b12a2426b42a0a044c4840af01886_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzEzLTctMS0xLTA_c8398a88-e9f3-47ed-a0a4-e06a1c714a45"
      unitRef="usd">80059000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTEtMS0xLTA_dbf63082-86f9-42ed-acd9-807bf1b682dc"
      unitRef="usd">55335000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTMtMS0xLTA_b89c82a5-6ccb-48ca-8f3c-fb1e1400183b"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTUtMS0xLTA_6252e79b-9377-47ba-9ef8-b342ae16dc5b"
      unitRef="usd">96000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="ia8b9071ac2ee4cdfa8c521452dba6560_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE0LTctMS0xLTA_ee17429f-8a16-48fc-ac19-a1eb596b2ea1"
      unitRef="usd">55239000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTEtMS0xLTA_9e2b8470-6945-4db8-a18a-fbad43cd151f"
      unitRef="usd">207000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTMtMS0xLTA_379bfc2c-9734-490b-baf8-756d37734ef7"
      unitRef="usd">1689000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTUtMS0xLTA_2a3d0ba4-02b6-4633-abf9-c552a11b8a2c"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i9251dd4d31b7498093e1f44f4c5947dc_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE1LTctMS0xLTA_972ceda9-2e9e-4baf-92d0-a7f64710da44"
      unitRef="usd">1896000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i314bde6d607f4e658a119ca41affb344_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTEtMS0xLTA_ead9502e-7f21-46c6-9846-1dc0e6e790ff"
      unitRef="usd">27933000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i314bde6d607f4e658a119ca41affb344_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTMtMS0xLTA_9a849405-0b39-4cbc-bef8-8a899badda55"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i314bde6d607f4e658a119ca41affb344_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTUtMS0xLTA_48da69ce-44f2-451c-815e-521a15986459"
      unitRef="usd">20000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i314bde6d607f4e658a119ca41affb344_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE2LTctMS0xLTA_12c23c10-9d54-47cf-95ec-081984ab4ddf"
      unitRef="usd">27913000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i08498294a183499a9bf71fb60b17b954_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTEtMS0xLTA_6b4f48fd-6caf-4931-82ea-cc4c4c1c305f"
      unitRef="usd">4991000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i08498294a183499a9bf71fb60b17b954_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTMtMS0xLTA_bdc44bf2-a958-4558-855c-7ec132e0a956"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i08498294a183499a9bf71fb60b17b954_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTUtMS0xLTA_e0297a65-e3c5-4988-afe0-8c6f1f576f5e"
      unitRef="usd">1000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i08498294a183499a9bf71fb60b17b954_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE3LTctMS0xLTA_9324c03d-a6e7-477c-a3ae-ec794c499c30"
      unitRef="usd">4990000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTEtMS0xLTA_0e7e0f4d-024a-43d8-b2cc-d88113eadf72"
      unitRef="usd">8939000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTMtMS0xLTA_a27722ef-1d05-484d-9604-9f34b4ce7193"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTUtMS0xLTA_73bd347d-54b5-40c2-a3e3-3a062317b757"
      unitRef="usd">10000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="i9c4120046acd4fc69f355bb557d7c4d1_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE4LTctMS0xLTA_70eae45a-11ea-49bb-a712-2eca5ceb3d76"
      unitRef="usd">8929000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTEtMS0xLTA_b3e8ea7c-5250-4b1a-bec9-a62aa34209b0"
      unitRef="usd">2028000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTMtMS0xLTA_7f94710c-86ab-44ae-9d07-c43b51066981"
      unitRef="usd">0</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTUtMS0xLTA_d21eea63-dc89-42fc-b532-00b55391c333"
      unitRef="usd">13000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="if120a59cc3604cb3ad3491acaa5c4d79_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzE5LTctMS0xLTA_b14cffa1-22f8-4844-af29-4d11e4f4434e"
      unitRef="usd">2015000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis
      contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTEtMS0xLTA_e90b725d-893a-46cf-af5f-1af2b5483777"
      unitRef="usd">179528000</us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax
      contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTMtMS0xLTA_38380b06-df7e-4d81-ad29-4f272e04a038"
      unitRef="usd">1695000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax>
    <us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
      contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTUtMS0xLTA_8f77e9e3-50c5-4e0d-b4dd-eb2ff5dc41a6"
      unitRef="usd">182000</us-gaap:AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax>
    <us-gaap:AvailableForSaleSecuritiesDebtSecurities
      contextRef="iac339cad857c45998c60f10b6d6bf7da_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplMWEzZjQzZjYyOWE0MDA2OWViODYwZWUyOGViZmRkZC90YWJsZXJhbmdlOmUxYTNmNDNmNjI5YTQwMDY5ZWI4NjBlZTI4ZWJmZGRkXzIwLTctMS0xLTA_b752c528-8386-4ddb-a77e-6830e710fe11"
      unitRef="usd">181041000</us-gaap:AvailableForSaleSecuritiesDebtSecurities>
    <us-gaap:ScheduleOfOtherCurrentAssetsTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDA_df2297b3-d2ef-4de4-8d34-bb95053fc5ed">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Other current assets consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restricted cash&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking warrants&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;9,257&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,545&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,418&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,514&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfOtherCurrentAssetsTableTextBlock>
    <us-gaap:RestrictedCashCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzMtMS0xLTEtMA_0967caec-0b68-4739-b90d-ff1c5888cc81"
      unitRef="usd">2616000</us-gaap:RestrictedCashCurrent>
    <us-gaap:RestrictedCashCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzMtMy0xLTEtMA_d1ec1b49-847e-43ac-bb4d-1c6ffd649038"
      unitRef="usd">0</us-gaap:RestrictedCashCurrent>
    <lgnd:WarrantsCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMS0xLTEtODMyNQ_1df87807-7032-4bb3-82e5-2032aa3d2997"
      unitRef="usd">9257000</lgnd:WarrantsCurrent>
    <lgnd:WarrantsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMy0xLTEtODMyMQ_7833371e-b0ca-4b12-9bab-099b1acb1ceb"
      unitRef="usd">0</lgnd:WarrantsCurrent>
    <lgnd:OtherAssetsCurrentOther
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMS0xLTEtMA_0f622cc3-6937-42cb-ab06-949226a99131"
      unitRef="usd">8545000</lgnd:OtherAssetsCurrentOther>
    <lgnd:OtherAssetsCurrentOther
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzQtMy0xLTEtMA_73e31a3d-6a61-49f3-a149-3c173c797e0c"
      unitRef="usd">1514000</lgnd:OtherAssetsCurrentOther>
    <us-gaap:OtherAssetsCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzUtMS0xLTEtMA_b171ca13-55bb-4f17-b081-0fda91d40748"
      unitRef="usd">20418000</us-gaap:OtherAssetsCurrent>
    <us-gaap:OtherAssetsCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTozNTVlYzVjYzViMTc0MWEzOTEyYTlmNGM0ZjFjZTU4OS90YWJsZXJhbmdlOjM1NWVjNWNjNWIxNzQxYTM5MTJhOWY0YzRmMWNlNTg5XzUtMy0xLTEtMA_f8c75495-222f-474f-8ca4-32889eae2787"
      unitRef="usd">1514000</us-gaap:OtherAssetsCurrent>
    <us-gaap:PropertyPlantAndEquipmentTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDE_bb7af50b-c6d2-4bdf-b782-2c323fe12c5d">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Property and equipment is stated at cost and consists of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Lab and office equipment&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,183&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,460&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Leasehold improvements&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,418&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,917&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Computer equipment and software&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;936&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;697&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,537&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,074&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Less accumulated depreciation and amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,165)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,862)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,212&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:PropertyPlantAndEquipmentTextBlock>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="i16fdeb617d3e4ad69654c02d20dca967_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzItMS0xLTEtMA_b1e942f7-5d0b-452c-89c8-7ef78d1c5b9e"
      unitRef="usd">4183000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="iac24af30dd5947d69f092c0143c72cd5_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzItMy0xLTEtMA_3b0a044d-2912-4c02-9c3b-6afe2613de02"
      unitRef="usd">3460000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="i4e5237e21cd94cbe8fb403d08bacef1f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzMtMS0xLTEtMA_3b52bd83-89f1-45dd-bbdb-95f06cbf319d"
      unitRef="usd">2418000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="i5d2d421f80254076b1c05f7d56f73e55_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzMtMy0xLTEtMA_70227321-3d56-441d-9216-77b7efabb190"
      unitRef="usd">1917000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="ic146a47155124f8587de68b7f7bf2916_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzQtMS0xLTEtMA_62d9f88d-903b-4c85-a53c-98947c6efad3"
      unitRef="usd">936000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="i2f59fb3a08394604ad40621952d209ac_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzQtMy0xLTEtMA_8aaa2ec4-6f9d-4519-b299-c45c8587f325"
      unitRef="usd">697000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzUtMS0xLTEtMA_8949223b-acbf-487d-b109-33049e5abdfa"
      unitRef="usd">7537000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:PropertyPlantAndEquipmentGross
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzUtMy0xLTEtMA_205f67cb-1a07-48c8-9eac-32ae1630018c"
      unitRef="usd">6074000</us-gaap:PropertyPlantAndEquipmentGross>
    <us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzYtMS0xLTEtMA_85df652c-ddb0-402e-8bb9-0192a5c1511b"
      unitRef="usd">2165000</us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment>
    <us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzYtMy0xLTEtMA_9290a1ff-2fe2-4985-8492-cf06a2baa2c8"
      unitRef="usd">1862000</us-gaap:AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment>
    <us-gaap:PropertyPlantAndEquipmentNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzctMS0xLTEtMA_e29c6eef-fc19-48ea-ac33-6245515452c9"
      unitRef="usd">5372000</us-gaap:PropertyPlantAndEquipmentNet>
    <us-gaap:PropertyPlantAndEquipmentNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo0ODhjMzhmNjI1NjY0MDU4YjM1MjMxZjMxMWQ0MGJmZi90YWJsZXJhbmdlOjQ4OGMzOGY2MjU2NjQwNThiMzUyMzFmMzExZDQwYmZmXzctMy0xLTEtMA_d8c43a48-c36c-45f3-a670-7d4393927db3"
      unitRef="usd">4212000</us-gaap:PropertyPlantAndEquipmentNet>
    <us-gaap:Depreciation
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY1MA_a1081043-7c8f-4d53-b198-09c6daf8b492"
      unitRef="usd">900000</us-gaap:Depreciation>
    <us-gaap:Depreciation
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY1NA_c0980122-ee6f-441f-bb6d-15a69e9ef586"
      unitRef="usd">400000</us-gaap:Depreciation>
    <us-gaap:Depreciation
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzY2Mg_9fd82494-a3bd-481b-87fe-9b274e174f11"
      unitRef="usd">200000</us-gaap:Depreciation>
    <us-gaap:ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDI_6dde6194-39ec-4ba8-952e-d7c997fc38d4">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Goodwill and identifiable intangible assets consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Indefinite lived intangible assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     IPR&amp;amp;D&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,923&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Goodwill&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;86,646&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;85,959&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Definite lived intangible assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Complete technology&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;235,413&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;222,900&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(35,070)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(23,301)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Trade name&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,642&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,642&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,048)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(916)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Customer relationships&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;          Less: Accumulated amortization&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(11,744)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,264)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total goodwill and other identifiable intangible assets, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;306,439&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;314,543&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock>
    <us-gaap:IndefiniteLivedIntangibleAssetsExcludingGoodwill
      contextRef="if00b0dbd22ec4957944d58677bc41590_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzMtMy0xLTEtMA_134e3a11-bce4-4296-bdf8-d9be18fae38e"
      unitRef="usd">7923000</us-gaap:IndefiniteLivedIntangibleAssetsExcludingGoodwill>
    <us-gaap:Goodwill
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzQtMS0xLTEtMA_918c94de-9039-43f9-a2dd-4753eea5a886"
      unitRef="usd">86646000</us-gaap:Goodwill>
    <us-gaap:Goodwill
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzQtMy0xLTEtMA_fbfa2c74-dfad-4389-a9b8-a1da564ea6fa"
      unitRef="usd">85959000</us-gaap:Goodwill>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzYtMS0xLTEtMA_64177eae-d980-4649-8580-a3aa4914ec5b"
      unitRef="usd">235413000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i17da7efba5044964a299fa1b88c45d89_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzYtMy0xLTEtMA_ce97c0d7-bf24-44f4-9dea-0a48609c3f99"
      unitRef="usd">222900000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="ifbb1af2f911649c98dc01b76a95a1b6f_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzctMS0xLTEtMA_bcaaf519-4809-4ea9-a0ad-21bc3bb742d2"
      unitRef="usd">35070000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="i17da7efba5044964a299fa1b88c45d89_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzctMy0xLTEtMA_2ddee11f-336a-4469-85dc-6514ef3a2717"
      unitRef="usd">23301000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i25a1b9803d204d8399b4072bc7f1feba_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzgtMS0xLTEtMA_2d0d495c-0bf8-4a09-bca5-7d93a49f97bd"
      unitRef="usd">2642000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i098eec66c5b3403da1e52d65ba40fb09_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzgtMy0xLTEtMA_bd3f4df9-e855-4cad-8773-c08c5f539812"
      unitRef="usd">2642000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="i25a1b9803d204d8399b4072bc7f1feba_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzktMS0xLTEtMA_31dc1cba-78a4-4b02-b4c8-1ad94f0c4711"
      unitRef="usd">1048000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="i098eec66c5b3403da1e52d65ba40fb09_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzktMy0xLTEtMA_3f1e6545-9cb8-42e7-8f1f-a73e5c9ce333"
      unitRef="usd">916000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEwLTEtMS0xLTA_b940a4db-816f-4e47-92ba-de610285cce1"
      unitRef="usd">29600000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsGross
      contextRef="ida0878f2976a419ab990ac37bb697cf4_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEwLTMtMS0xLTA_4213e99c-bbbe-46ad-b765-24b7f8619d85"
      unitRef="usd">29600000</us-gaap:FiniteLivedIntangibleAssetsGross>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="i985547ad7ca64cb5b0d3b8b61bbf2f9b_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzExLTEtMS0xLTA_68e7973e-8d02-48e3-b89c-9ec6117d896e"
      unitRef="usd">11744000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization
      contextRef="ida0878f2976a419ab990ac37bb697cf4_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzExLTMtMS0xLTA_ef6b95da-6bcf-40bb-bea9-c30dee61aa15"
      unitRef="usd">10264000</us-gaap:FiniteLivedIntangibleAssetsAccumulatedAmortization>
    <us-gaap:IntangibleAssetsNetIncludingGoodwill
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEyLTEtMS0xLTA_220bc792-b815-43b9-a20c-0e0c803ffe21"
      unitRef="usd">306439000</us-gaap:IntangibleAssetsNetIncludingGoodwill>
    <us-gaap:IntangibleAssetsNetIncludingGoodwill
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTowZGViMmQxMTk3ODU0NTU4OGRjM2YyZDA5ZTJiNTllNS90YWJsZXJhbmdlOjBkZWIyZDExOTc4NTQ1NTg4ZGMzZjJkMDllMmI1OWU1XzEyLTMtMS0xLTA_f53d13fe-c29c-45c9-99b3-c68b4f5a5d2d"
      unitRef="usd">314543000</us-gaap:IntangibleAssetsNetIncludingGoodwill>
    <us-gaap:FiniteLivedIntangibleAssetUsefulLife
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzU0OTc1NTgxNzc0NA_92d88571-6fb1-40a3-8993-a97348071153">P20Y</us-gaap:FiniteLivedIntangibleAssetUsefulLife>
    <us-gaap:AmortizationOfIntangibleAssets
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwMzI_681dfa64-f652-49a3-ae2d-08ad13b3d19f"
      unitRef="usd">15800000</us-gaap:AmortizationOfIntangibleAssets>
    <us-gaap:AmortizationOfIntangibleAssets
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwMzY_a51a4417-11db-4cfc-bf50-b59a47cd9d42"
      unitRef="usd">11300000</us-gaap:AmortizationOfIntangibleAssets>
    <us-gaap:AmortizationOfIntangibleAssets
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzEwNDQ_ab306f40-1311-4164-88e8-1e44366b3d09"
      unitRef="usd">10600000</us-gaap:AmortizationOfIntangibleAssets>
    <us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzExODk_64cc8508-fd98-44cb-93e1-4015ebf6b9dd"
      unitRef="usd">13600000</us-gaap:FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths>
    <us-gaap:ImpairmentOfIntangibleAssetsFinitelived
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzU0OTc1NTgxNzY2Mw_286b381d-656a-4834-8340-624fc7312873"
      unitRef="usd">0</us-gaap:ImpairmentOfIntangibleAssetsFinitelived>
    <us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5Xzk4OTU2MDQ2NTM2MDM_c448bdcc-2d27-4001-8412-b9921a56450f">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Accrued liabilities consist of the following (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:72.008811%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Compensation&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,045&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,085&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Legal&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;942&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;430&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Amounts owed to former licensees&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;428&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;396&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Royalties owed to third parties&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,025&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;954&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments due to broker for share repurchases&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,613&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Return reserve&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,590&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Restructuring&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,093&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,464&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,512&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,200&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7,377&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock>
    <us-gaap:EmployeeRelatedLiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzItMS0xLTEtMA_00dba084-97fa-4983-9826-4b18bbe29fc9"
      unitRef="usd">4045000</us-gaap:EmployeeRelatedLiabilitiesCurrent>
    <us-gaap:EmployeeRelatedLiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzItMy0xLTEtMA_7365ecdf-237f-4438-8d55-fbe232488ea2"
      unitRef="usd">4085000</us-gaap:EmployeeRelatedLiabilitiesCurrent>
    <us-gaap:AccruedProfessionalFeesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzMtMS0xLTEtMA_20297378-11aa-4e2a-93b1-db299158e919"
      unitRef="usd">942000</us-gaap:AccruedProfessionalFeesCurrent>
    <us-gaap:AccruedProfessionalFeesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzMtMy0xLTEtMA_5c27cc13-1be5-4fb0-b3a8-c332c374c0e4"
      unitRef="usd">430000</us-gaap:AccruedProfessionalFeesCurrent>
    <us-gaap:AccruedSalesCommissionCurrentAndNoncurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzQtMS0xLTEtMA_199e3b76-f0fd-489c-8c38-79d45e317e07"
      unitRef="usd">428000</us-gaap:AccruedSalesCommissionCurrentAndNoncurrent>
    <us-gaap:AccruedSalesCommissionCurrentAndNoncurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzQtMy0xLTEtMA_ac4a4732-e2fd-4be4-bba4-11d3fb8ea84d"
      unitRef="usd">396000</us-gaap:AccruedSalesCommissionCurrentAndNoncurrent>
    <us-gaap:AccruedRoyaltiesCurrentAndNoncurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzUtMS0xLTEtMA_84c009eb-bb02-4243-b4a7-b9b05ec31073"
      unitRef="usd">1025000</us-gaap:AccruedRoyaltiesCurrentAndNoncurrent>
    <us-gaap:AccruedRoyaltiesCurrentAndNoncurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzUtMy0xLTEtMA_e3116f74-8cbd-46d7-9af6-b510290e43e2"
      unitRef="usd">954000</us-gaap:AccruedRoyaltiesCurrentAndNoncurrent>
    <lgnd:AccruedStockRepurchases
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMS0xLTEtMTIzOTU_b9d32676-bbc8-4eeb-bb64-b97d1c37d101"
      unitRef="usd">4613000</lgnd:AccruedStockRepurchases>
    <lgnd:AccruedStockRepurchases
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMy0xLTEtMTI0MDQ_01840227-367d-40bd-b710-202f77e5e76b"
      unitRef="usd">0</lgnd:AccruedStockRepurchases>
    <lgnd:AccruedSalesReturns
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMS0xLTEtMTIzOTg_521dfc95-21f0-44db-9caf-44ffb2bc743a"
      unitRef="usd">3590000</lgnd:AccruedSalesReturns>
    <lgnd:AccruedSalesReturns
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMy0xLTEtMTI0MDc_3cb4a28d-aa71-4586-b895-20f470c00804"
      unitRef="usd">0</lgnd:AccruedSalesReturns>
    <us-gaap:RestructuringReserveCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzktMS0xLTEtMTI0MDE_0ab61afa-e8f4-424a-a35b-9810b4b47c8c"
      unitRef="usd">1093000</us-gaap:RestructuringReserveCurrent>
    <us-gaap:RestructuringReserveCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzktMy0xLTEtMTI0MTA_e35cd5c2-aa9e-4962-adab-702d1a3b13fb"
      unitRef="usd">0</us-gaap:RestructuringReserveCurrent>
    <us-gaap:OtherAccruedLiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMS0xLTEtMA_bb45ba31-c24c-4ef4-9910-217ca9f80a60"
      unitRef="usd">3464000</us-gaap:OtherAccruedLiabilitiesCurrent>
    <us-gaap:OtherAccruedLiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzctMy0xLTEtMA_0f21cd11-a3a2-43c8-947f-d7b0fe657d2e"
      unitRef="usd">1512000</us-gaap:OtherAccruedLiabilitiesCurrent>
    <us-gaap:AccruedLiabilitiesCurrent
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMS0xLTEtMA_5bb7ff54-1aa1-496d-964d-fed783e96b28"
      unitRef="usd">19200000</us-gaap:AccruedLiabilitiesCurrent>
    <us-gaap:AccruedLiabilitiesCurrent
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTplZmM3MzZhNGQyMDI0Yjg4YTQ0ODJlNzIxZDBmOWQ1Yi90YWJsZXJhbmdlOmVmYzczNmE0ZDIwMjRiODhhNDQ4MmU3MjFkMGY5ZDViXzgtMy0xLTEtMA_87899b09-bfed-46ac-9f45-3d2fda5a485b"
      unitRef="usd">7377000</us-gaap:AccruedLiabilitiesCurrent>
    <lgnd:RevenueRoyaltytoAcquireeShareholdersPercent
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE3Mjk_6758946c-1302-469a-b701-23987b5f07f9"
      unitRef="number">0.20</lgnd:RevenueRoyaltytoAcquireeShareholdersPercent>
    <lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE4NTk_a13d6ffc-562c-4b3a-ad57-6ad7f48fe136"
      unitRef="usd">15000000.0</lgnd:ThresholdRevenueAmounttoTriggerRoyaltyPayments>
    <lgnd:AdditionalRevenueRoyaltytoAcquireeShareholdersPercent
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzE4ODI_9559f44b-909a-4d8a-a63b-47553ab8dba6"
      unitRef="number">0.10</lgnd:AdditionalRevenueRoyaltytoAcquireeShareholdersPercent>
    <lgnd:ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzIwNDU_0f66db7a-540e-4064-b035-fbd9f4323df1"
      unitRef="usd">35000000.0</lgnd:ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments>
    <lgnd:ScheduleofContingentLiabilitiesTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90ZXh0cmVnaW9uOjIzMmQwZGQ0ZGE0NjQ2MjViNjNlOWIxZTk3ZWE0ZjU5XzgyNDYzMzcyMTQxMDA_47feb5ee-ac7f-471b-b2d5-22af4629fdd8">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes contingent liabilities&#160;as of December 2018 and 2017 (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.736842%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.265432%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.876543%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:7.413580%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.419753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.728395%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Additions&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Payments&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fair Value Adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Cydex&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(5,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,600&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(25)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,050)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;525&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Metabasis&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,900)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Crystal&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(924)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,476&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total &lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,100&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(5,000)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,500&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,000&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,925)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,426&#160;&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,501&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</lgnd:ScheduleofContingentLiabilitiesTableTextBlock>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="ic732878aa6064bd6999a01fcb26ffafb_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMS0xLTEtMA_39da92aa-6ce8-4c51-a7b6-ba657fa79fad"
      unitRef="usd">6600000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMi0xLTEtMA_fb9f0be1-b89d-4846-8637-177b8e49255a"
      unitRef="usd">5000000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtMy0xLTEtMA_93a2711f-b11c-4cef-ad99-2db86b9d6387"
      unitRef="usd">0</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions
      contextRef="i7a2d42893cd644a68777988972f1db82_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNS0xLTEtOTAwMg_49cfc8ff-d24c-4014-8f5f-ae250603592b"
      unitRef="usd">0</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="idfb5b3bf1daa4956a0677ba6e2b17a09_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNS0xLTEtMA_a961ee97-6463-4498-8c52-e7555469c710"
      unitRef="usd">1600000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNi0xLTEtMA_8a6fc826-4eef-460b-8b6f-9c6d31b81ac5"
      unitRef="usd">25000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="i794200b309194b26a0fa0ace6a16a745_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtNy0xLTEtMA_5c3a8ed8-35a2-4e02-b4c9-236b7630fa74"
      unitRef="usd">-1050000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i6555f01d1e2a414bb4602de9db064582_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzEtOS0xLTEtMA_8200f913-fd99-4e25-bab9-837b41ae952d"
      unitRef="usd">525000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i04a307d0dd25404c9e1b6973b4fcfcfc_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMS0xLTEtMA_7901e98d-8438-4e48-81fb-4d31494e5717"
      unitRef="usd">1500000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMi0xLTEtMA_c20eec57-7f21-4629-aaf2-c7b92ab24c9f"
      unitRef="usd">0</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItMy0xLTEtMA_7e14a5e6-d758-491a-927f-d5a974549c7b"
      unitRef="usd">2500000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions
      contextRef="ib90242a1f1084a72890da4139394161b_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNS0xLTEtOTAwNA_83ef62e0-2646-466a-b7d7-63d7270661f5"
      unitRef="usd">0</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i962f4a871df84f71a3762aabb69d87d4_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNS0xLTEtMA_1d76ebee-e553-4a0e-9e4b-e4575964d323"
      unitRef="usd">4000000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNi0xLTEtMA_08cdfddd-3274-4bbf-9bc8-6f2c960b208c"
      unitRef="usd">3900000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="iab067f7fade348cd8a79b801cff7838c_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItNy0xLTEtMA_976fcf78-e6fa-4adb-a49a-9b61cf62cb52"
      unitRef="usd">5400000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i5a6f5527bcd749ebb994ee78a83dec16_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzItOS0xLTEtMA_8e664e50-e8dc-4987-9eae-4e75fb995a31"
      unitRef="usd">5500000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i3ddcb2326de24ff388c9dabc96f2f7ab_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMS0xLTEtMA_1c916c1b-d296-423f-8587-c5dde4240c10"
      unitRef="usd">0</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMi0xLTEtMA_b11b7218-f364-4878-9e4d-73fd47679a66"
      unitRef="usd">0</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtMy0xLTEtMA_3c2e5243-b693-4a57-817d-441578736cf6"
      unitRef="usd">0</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions
      contextRef="ia96387c68e204b4388e9977b060ff288_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNS0xLTEtOTAwNg_a5f07c89-82f3-44b5-b871-3ad3e1b6480f"
      unitRef="usd">8400000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i3dc153fa027840bfaf8d39d7777fca8a_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNS0xLTEtMA_f1c707aa-bd5a-46d8-8c15-94beb67b22c6"
      unitRef="usd">8400000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNi0xLTEtMA_04f14177-7a40-4f8d-8672-ab78ebe342f7"
      unitRef="usd">1000000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="i473d204eb0a340c083969f9a7077c1ed_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtNy0xLTEtMA_de671289-3618-47f8-aeff-465cbc6b5555"
      unitRef="usd">-924000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i302632e5fe1b4a5f83193f9bdf7204aa_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzMtOS0xLTEtMA_6b0f7944-d348-478e-839e-bd14bf5f5871"
      unitRef="usd">6476000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMS0xLTEtMA_5b87a64e-a9a4-49f6-8384-bdada3ff00fe"
      unitRef="usd">8100000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMi0xLTEtMA_14fdec41-bf43-4116-b164-edcce2cddbc6"
      unitRef="usd">5000000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtMy0xLTEtMA_5c573fae-eb0e-4287-a56b-9ed12a7df405"
      unitRef="usd">2500000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNS0xLTEtOTAwOA_0099295f-7dd4-40d6-8de8-999ca68215cd"
      unitRef="usd">8400000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNS0xLTEtMA_aa2dc567-297c-4685-841b-94b051b92907"
      unitRef="usd">14000000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <lgnd:PaymentsToContingentValueRightHolders
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNi0xLTEtMA_4ecbc9a1-d929-42ae-b9a5-44c2732f7d8c"
      unitRef="usd">4925000</lgnd:PaymentsToContingentValueRightHolders>
    <lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtNy0xLTEtMA_63bc3b80-f2a5-47d9-9e9c-a942fef0993e"
      unitRef="usd">3426000</lgnd:FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities>
    <lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80NTcvZnJhZzoyMzJkMGRkNGRhNDY0NjI1YjYzZTliMWU5N2VhNGY1OS90YWJsZTo2OWVhYWEzNzY0M2Y0NWJhOTMwMzgyODkzMzJjZjU0NS90YWJsZXJhbmdlOjY5ZWFhYTM3NjQzZjQ1YmE5MzAzODI4OTMzMmNmNTQ1XzQtOS0xLTEtMA_9b255e66-b0f3-4e9c-a645-48c353123f46"
      unitRef="usd">12501000</lgnd:BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod>
    <us-gaap:StockholdersEquityNoteDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI4Njg_d62cb370-baae-46f1-9f71-82235d2d666f">Stockholders&#x2019; Equity&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Share-based Compensation Expense&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes share-based compensation expense (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:63.102639%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Share-based compensation expense as a component of:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research and development expenses&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,352&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,235&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,836&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;General and administrative expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,494&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,680&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,057&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,915&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;18,893&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Stock Plans&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;In May 2012 and May 2016, our 2002 Stock Incentive Plan was amended to increase the number of shares available for issuance by 1.8 million&#160;&#160;and 0.9 million shares, respectively.  As of December&#160;31, 2018, there were 0.6 million shares available for future option grants or direct issuance under the Amended 2002 Plan.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Following is a summary of our stock option plan activity and related information:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:48.220913%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.340206%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Exercise&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Remaining&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Contractual&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Term in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Years&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Aggregate&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Intrinsic&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Value&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;(In&#160; thousands)&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at December&#160;31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,876,332&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53.17&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.77&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;157,340&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Granted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;228,362&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;162.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercised&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(358,162)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55.24&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Forfeited&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,228)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;114.53&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,736,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125,858&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercisable at December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,313,374&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47.03&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.56&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;117,314&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Options vested and expected to vest as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,734,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125,858&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The weighted-average grant-date fair value of all stock options granted during 2018, 2017 and 2016 was $66.71, $53.17 and $46.53 per share, respectively. The total intrinsic value of all options exercised during 2018, 2017 and 2016 was approximately $51.9 million, $13.3 million and&#160;$12.0 million, respectively. &lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Cash received from options exercised, net of fees paid, in 2018, 2017 and 2016 was $19.8 million, $4.7 million and $6.2 million, respectively. &lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Following is a further breakdown of the options outstanding as of December&#160;31, 2018:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:25.366864%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.391716%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:14.568047%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Range of exercise prices&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Options&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;outstanding&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;remaining&#160; life&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;in&#160;years&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&#160;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercise price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Options&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercisable&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&#160;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercise&#160;price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$8.58 - $10.05&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;184,702&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.87&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;184,702&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$10.12 - $12.81&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,510&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.92&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,510&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$14.47 - $14.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;217,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.11&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;203,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$16.14 - $17.88&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,790&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.17&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,790&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$21.92 - $21.92&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;200,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.13&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;200,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$32.00 - $56.26&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;182,767&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.70&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;174,470&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50.10&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$63.58 - $67.53&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,434&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.44&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,153&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$74.42 - $74.42&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;190,825&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.12&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;74.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;190,825&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;74.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$85.79 - $100.38&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;299,282&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7.57&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;93.32&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;157,872&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;91.62&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$101.15 - $195.91&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;353,006&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8.79&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;148.50&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;96,064&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;131.77&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,734,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,313,374&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47.03&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.538012%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.709199%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.986944%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.541840%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.541840%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="18" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.7%-3.0%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.0%-2.2%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.3%-1.9%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expected volatility&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33%-36%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43%-47%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;48%-50%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expected term&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.1 to 5.8 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6.5 to 6.8 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6.6 to 6.7 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:27pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December&#160;31, 2018, there was $20.4 million of total unrecognized compensation cost related to non-vested stock options.  That cost is expected to be recognized over a weighted average period of 2.39 years.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:14pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Restricted Stock Activity&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following is a summary of our restricted stock activity and related information:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:71.127753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.509545%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted-Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Grant&#160;Date Fair&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Value&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Outstanding at December&#160;31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;133,294&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;91.60&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Granted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;62,133&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;169.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Vested&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(61,989)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;86.19&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Forfeited&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,165)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125.16&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Outstanding at December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;132,273&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;130.63&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December&#160;31, 2018, unrecognized compensation cost related to non-vested stock awards amounted to $9.2&#160;million. That cost is expected to be recognized over a weighted average period of&#160;1.38 years.&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Employee Stock Purchase Plan&lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December 31, 2018, 64,008 shares of our common stock are available for future issuance under the Amended Employee Stock Purchase Plan, or ESPP.  The ESPP permits eligible employees to purchase up to 1,250 shares of Ligand common stock per calendar year at a discount through payroll deductions. The price at which stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first of a six month offering period or purchase date, whichever is lower. There were 3,386, 3,061 and 1,961 shares issued under the ESPP in 2018, 2017 and 2016, respectively. &lt;/span&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;"&gt;Share Repurchases &lt;/span&gt;&lt;/div&gt;In May 2018, in conjunction with our&#160;2023 Notes debt offering,&#160;we repurchased 260,000 shares of our&#160;common stock at&#160;a cost of $191.14 per share. In September 2018, the&#160;board of directors authorized us to repurchase up to $200.0 million of our common stock&#160;from time to time over a period of up to three years&#160;(the &#x201c;Repurchase Program&#x201d;). As of December 31, 2018, $125.2 million remains available for repurchase under the&#160;authorized program.&#160;On January 23, 2019, the board of directors elected to increase the Repurchase Program, authorizing us to repurchase up to a maximum of $350.0 million of our outstanding common stock under the Repurchase Program. The Repurchase Program will expire, as originally scheduled, on September 20, 2021.&#160;Since December 31, 2018 and as of February 28, 2019, we acquired 400,177 additional shares during 2019, and the maximum dollar value of shares that may yet be purchased under the Repurchase Program was $225.9 million.During the years ended December&#160;31, 2018, 2017 and 2016, we repurchased 782,248 shares for $127.5 million, 14,000&#160;shares for $2.0 million, and&#160;40,500&#160;shares for&#160;$3.9 million, respectively.</us-gaap:StockholdersEquityNoteDisclosureTextBlock>
    <lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDQ_3a9e00bd-146e-416a-beb7-9e7b52c12ab4">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following table summarizes share-based compensation expense (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:63.102639%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.533138%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.143695%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Share-based compensation expense as a component of:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research and development expenses&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,352&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,235&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,836&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;General and administrative expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,494&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,680&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,057&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,846&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,915&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;18,893&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="idaab1982bed149178b9a7a902d4ec9b1_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtMS0xLTEtMA_93e1dbe6-9717-46d5-9aba-205600419885"
      unitRef="usd">8352000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i5525fb7204b24ebb9a94c522e3490ed3_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtMy0xLTEtMA_f1d93bc7-046e-4d52-8a1c-5eee8b8770fd"
      unitRef="usd">14235000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i660b0db80fb243a9aa215587f3e20997_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzMtNS0xLTEtMA_77e8b3d5-97cd-44fa-a60b-6bc79ac1ff7a"
      unitRef="usd">8836000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i6387378ce4f1495fbf9934bbc7f8004b_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtMS0xLTEtMA_5f71c08f-b3de-4cce-8569-8e02f9d48c0e"
      unitRef="usd">12494000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i008883d729b243ce80c4af9827bf6117_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtMy0xLTEtMA_6fbb4243-7912-404e-a086-b7bf83e3c8f0"
      unitRef="usd">10680000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i9e6c1c39ab414f958545d7f4f2e968ea_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzQtNS0xLTEtMA_4a2eccbc-238a-4cbe-ba0c-c45503e8bb2c"
      unitRef="usd">10057000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtMS0xLTEtMA_38eef9b0-fa1b-4d7b-bde7-8f59d3b89200"
      unitRef="usd">20846000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtMy0xLTEtMA_51fba997-2ddc-45d2-bf3d-b88891b2a1bf"
      unitRef="usd">24915000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZToxMDNlZDc1YmY0ODU0NDg0OTNlM2M5ZjIwNzVjZmE3Zi90YWJsZXJhbmdlOjEwM2VkNzViZjQ4NTQ0ODQ5M2UzYzlmMjA3NWNmYTdmXzUtNS0xLTEtMA_179dc4e3-2d79-4f51-890b-9eb3f56dcd1c"
      unitRef="usd">18893000</us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
      contextRef="i8122f73ad096454d8683e1fb385d450f_D20120530-20120531"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM2Mw_bef35512-3c6f-486c-8570-534edd7a558f"
      unitRef="shares">1800000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
      contextRef="i10821c8abf4c413496e40313cc3d82c6_D20160501-20160531"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM3MQ_6dc4866c-d74c-4b07-bdee-6b0275a15586"
      unitRef="shares">900000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
      contextRef="iefc813acbb6448ec99d57a49fe36770e_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzQxOA_c2dfe8b4-e03d-499e-9de7-954507a48953"
      unitRef="shares">600000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant>
    <us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDM_904f58e9-0e78-4ba5-935a-f2898483f70a">&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Following is a summary of our stock option plan activity and related information:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:48.220913%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.076583%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.340206%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Exercise&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Remaining&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Contractual&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Term in&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Years&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Aggregate&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Intrinsic&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Value&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;(In&#160; thousands)&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at December&#160;31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,876,332&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;53.17&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.77&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;157,340&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Granted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;228,362&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;162.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercised&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(358,162)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;55.24&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Forfeited&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,228)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;114.53&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at December 31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,736,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125,858&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Exercisable at December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,313,374&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47.03&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.56&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;117,314&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Options vested and expected to vest as of December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,734,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125,858&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtMS0xLTEtMA_a9aa0dec-641b-4d12-893e-a8bc698a3f19"
      unitRef="shares">1876332</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtMy0xLTEtMA_7517e4bd-6bbb-452f-8a77-fc454fde1203"
      unitRef="usdPerShare">53.17</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtNS0xLTEtMA_dcb4e79b-85c5-4578-9d18-99dcfeb3ba41">P5Y9M7D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzEtNy0xLTEtMA_59072fac-a6fe-495a-83fc-341724d7272e"
      unitRef="usd">157340000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzItMS0xLTEtMA_27c17eb1-73ee-4c1c-94a9-695d56634a02"
      unitRef="shares">228362</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross>
    <us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzItMy0xLTEtMA_b1f26c2d-2ce2-45d8-b491-35602a9c3eab"
      unitRef="usdPerShare">162.00</us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice>
    <us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzMtMS0xLTEtMA_4644c3b8-cb07-47e9-8eef-53c5effbef75"
      unitRef="shares">358162</us-gaap:StockIssuedDuringPeriodSharesStockOptionsExercised>
    <us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzMtMy0xLTEtMA_ed9cccf7-c1fd-457b-a1ff-f7c58ba22cae"
      unitRef="usdPerShare">55.24</us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzQtMS0xLTEtMA_98efe3f7-086c-4fa5-9fca-13bef89c686a"
      unitRef="shares">10228</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod>
    <us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzQtMy0xLTEtMA_c66ed5c1-c583-4bb2-abc5-70f24d1dc4e8"
      unitRef="usdPerShare">114.53</us-gaap:ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtMS0xLTEtMA_6da5f6cf-4051-4ec5-a2fd-51949391477f"
      unitRef="shares">1736304</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtMy0xLTEtMA_369489dc-e4ef-4569-8386-a93d97eaace1"
      unitRef="usdPerShare">66.71</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtNS0xLTEtMA_856b6217-f2d6-4f20-820e-f50ec721bcfe">P5Y5M19D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzUtNy0xLTEtMA_85a3dcd3-f9d9-4ac9-a1fc-ae1b2ff552c4"
      unitRef="usd">125858000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtMS0xLTEtMA_8da2e11d-9e3d-41fc-ace9-ac43c85fe2fb"
      unitRef="shares">1313374</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtMy0xLTEtMA_2cc0476f-8a57-43a1-aecf-a971679b8059"
      unitRef="usdPerShare">47.03</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtNS0xLTEtMA_ed959b33-8175-4731-af61-6e649701e8d2">P4Y6M21D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzYtNy0xLTEtMA_1660af8b-b475-4278-bb8e-dadd6d6166fd"
      unitRef="usd">117314000</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctMS0xLTEtMA_add330cd-e1af-44cf-ba6b-8b9d2d8a6d2f"
      unitRef="shares">1734304</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctMy0xLTEtMA_45fb88e3-dc67-4a7b-ab91-f3537c7e0758"
      unitRef="usdPerShare">66.71</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice>
    <us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctNS0xLTEtMA_6cfb83b9-bbab-437b-b449-651bbfb3f036">P5Y5M19D</us-gaap:SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTozYzFjZTg1NzhhMDc0MmQyYjFjMmI1NTI1ZWNkMGZhNi90YWJsZXJhbmdlOjNjMWNlODU3OGEwNzQyZDJiMWMyYjU1MjVlY2QwZmE2XzctNy0xLTEtMA_ab22621b-c956-4c55-8e01-10e94e4744f8"
      unitRef="usd">125858000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
      contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcwOQ_69a92ff4-534a-4327-94a1-64edad59de0d"
      unitRef="usdPerShare">66.71</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
      contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcxMw_825775ce-f4cd-4a9f-8793-0209caa02bf4"
      unitRef="usdPerShare">53.17</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
      contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzcyMA_3e2a1b70-c54d-4471-a098-1f5615663c08"
      unitRef="usdPerShare">46.53</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
      contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzgzOA_07d56cfd-21ca-4024-b41b-86c2879e9ec4"
      unitRef="usd">51900000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
      contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzg0Mg_1bf97062-6222-4f43-a65e-9ee1927b14d8"
      unitRef="usd">13300000</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue
      contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAwOTI_1f23faff-97aa-41cc-a424-116a60b302e4"
      unitRef="usd">12000000.0</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue>
    <us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
      contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk0Ng_9c85b438-0785-4f9e-8718-bb2ca66e481e"
      unitRef="usd">19800000</us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions>
    <us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
      contextRef="i71280c7de2894e85ba3974d9a15da431_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk1MA_1321585e-2d0c-409f-9caf-1d7bd798329c"
      unitRef="usd">4700000</us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions>
    <us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions
      contextRef="i07a3c88d732b4e45a4deaf0eee057c59_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk1Nw_81ea2cbc-6a9b-4d08-bc02-7fe2d69ac8e8"
      unitRef="usd">6200000</us-gaap:ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions>
    <us-gaap:ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDI_ae220f3a-bd1e-4f83-accf-2483a0317472">&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Following is a further breakdown of the options outstanding as of December&#160;31, 2018:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:25.366864%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.391716%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.313609%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.539645%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:14.568047%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Range of exercise prices&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Options&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;outstanding&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;remaining&#160; life&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;in&#160;years&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&#160;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercise price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Options&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercisable&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted&#160;average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;exercise&#160;price&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$8.58 - $10.05&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;184,702&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.87&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;184,702&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10.00&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$10.12 - $12.81&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,510&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.92&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,510&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$14.47 - $14.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;217,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.11&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;203,616&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$16.14 - $17.88&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,790&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.17&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,790&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$21.92 - $21.92&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;200,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;4.13&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;200,372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$32.00 - $56.26&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;182,767&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.70&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50.38&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;174,470&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50.10&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$63.58 - $67.53&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,434&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.44&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,153&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67.47&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$74.42 - $74.42&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;190,825&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.12&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;74.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;190,825&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;74.42&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$85.79 - $100.38&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;299,282&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;7.57&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;93.32&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;157,872&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;91.62&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$101.15 - $195.91&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;353,006&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8.79&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;148.50&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;96,064&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;131.77&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,734,304&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.47&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;66.71&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,313,374&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;47.03&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtMS0xLTEtMA_09763811-6b9b-479f-8f20-fad0a0c37bba"
      unitRef="shares">184702</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i40c5b8ab08a54300ac33e971b7912b8b_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtMy0xLTEtMA_155013f7-a6aa-4c9e-a473-4f7f45e217aa">P1Y10M13D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtNS0xLTEtMA_6214f3bb-ee0e-472e-a8c6-b861d20e0678"
      unitRef="usdPerShare">10.00</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtNy0xLTEtMA_ae20dc5c-41cc-4372-9406-82e9c57e49a4"
      unitRef="shares">184702</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="i02a0eae6ee8f45419024489126f96d62_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEtOS0xLTEtMA_64178e28-b898-47de-a211-aac59c442f81"
      unitRef="usdPerShare">10.00</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItMS0xLTEtMA_1ee29ff0-d792-4dea-bad0-9e4d5755cb50"
      unitRef="shares">46510</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="ie821bbf2318f4f019ee636621375f551_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItMy0xLTEtMA_b538c56c-4ee2-4f72-923f-10f6ef996dd3">P2Y11M1D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItNS0xLTEtMA_adc44775-87d1-4bee-84aa-a9420b0d3c24"
      unitRef="usdPerShare">11.40</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItNy0xLTEtMA_0f9c2a78-5700-4ccc-b2f9-c2043163e6d3"
      unitRef="shares">46510</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="ibaa7b68584894ec79dc4a5e5eb399ae5_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzItOS0xLTEtMA_66d4ecf7-a0e4-48e1-82c5-84854d018f81"
      unitRef="usdPerShare">11.40</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtMS0xLTEtMA_2da2da54-db26-493e-a981-5e0af13d9c41"
      unitRef="shares">217616</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i9f92bbf537294e04a7642b8e345dd407_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtMy0xLTEtMA_f7802f34-a0f5-4d0a-87a1-8efd76db8ef0">P3Y1M9D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtNS0xLTEtMA_25ae2a25-05fa-47aa-a2ed-b0ebfa6a94dd"
      unitRef="usdPerShare">14.47</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtNy0xLTEtMA_7b3ef50a-ab15-4d0b-8cf4-439370af783d"
      unitRef="shares">203616</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="iaaac9c476ecc4afaa2ed93f40a060882_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzMtOS0xLTEtMA_c50a0448-3245-4ec3-8d5b-e140b994777d"
      unitRef="usdPerShare">14.47</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtMS0xLTEtMA_943fd8b7-fbc1-4c1f-b01d-fe2a5bd1c155"
      unitRef="shares">38790</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i8c9d02422c1648b2929162ffecf8bf50_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtMy0xLTEtMA_1983ed97-2ebf-4184-b01a-1df559d78ad0">P0Y2M1D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtNS0xLTEtMA_25c945fe-d0a2-49f3-a1e0-f7ad96059a35"
      unitRef="usdPerShare">16.36</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtNy0xLTEtMA_43348d23-9043-4d65-a2dd-a13818cd9686"
      unitRef="shares">38790</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="i7ebf0c5934be4604a4ed15d88fe6ec86_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzQtOS0xLTEtMA_320fdcd1-118f-478b-af71-0b0bf6ce8bd8"
      unitRef="usdPerShare">16.36</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtMS0xLTEtMA_b96a8eb2-c648-4d74-937d-ec00c24f2e70"
      unitRef="shares">200372</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i0fe1bae106c24fbf9d082f542b5f17a2_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtMy0xLTEtMA_cd26258b-aa6e-4bd1-afeb-3980f7f7e52d">P4Y1M17D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtNS0xLTEtMA_6d1f6473-9747-4708-be45-0bf19d648867"
      unitRef="usdPerShare">21.92</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtNy0xLTEtMA_d080bb6a-11ed-474c-8ee8-5ef180be1f30"
      unitRef="shares">200372</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="if74d2c0621f34efba8080e1e9711fb35_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzUtOS0xLTEtMA_33dbec29-d80b-4a2a-8c22-d5caa5905d61"
      unitRef="usdPerShare">21.92</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtMS0xLTEtMA_be2f1118-3f29-427e-a081-77dd1d690ed1"
      unitRef="shares">182767</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i92faeba614e34b3493a599209d077a07_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtMy0xLTEtMA_cd83eadd-8504-4408-b583-ad4e268a5c94">P5Y8M12D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtNS0xLTEtMA_b18d7649-d5cd-4c3d-81d3-fcd0901dced8"
      unitRef="usdPerShare">50.38</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtNy0xLTEtMA_24f7073e-0391-4e05-8cb9-b6a82bab6da0"
      unitRef="shares">174470</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="ia88d9bb235ee4445acd17f3571976ef0_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzYtOS0xLTEtMA_829899a8-6f09-4e9b-8e62-0709d53074ce"
      unitRef="usdPerShare">50.10</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="i161b18328a8442d6997ff80696b788bd_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctMS0xLTEtMA_984b7d66-38a8-43f0-a3f2-d1973eb48e81"
      unitRef="shares">20434</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i49579c63871a4171a7c35e5434c6825d_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctMy0xLTEtMA_dc3953c1-e558-4dbe-a9f2-b3dd23a508b8">P5Y5M8D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="i161b18328a8442d6997ff80696b788bd_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctNS0xLTEtMA_ad252db9-0a96-4bce-b712-6c249858c0d8"
      unitRef="usdPerShare">67.42</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="i161b18328a8442d6997ff80696b788bd_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctNy0xLTEtMA_c88c0657-806f-4d46-ba64-0c109f301593"
      unitRef="shares">20153</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="i161b18328a8442d6997ff80696b788bd_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzctOS0xLTEtMA_0f03298a-d655-4d21-bd72-2229c4143afa"
      unitRef="usdPerShare">67.47</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="i4246c537469d483abd783cecc40379d0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtMS0xLTEtMA_50dd8ba1-50ca-419b-8b81-26bea2647016"
      unitRef="shares">190825</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="ib10037af667140199ebf3bd9b6cfa7b9_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtMy0xLTEtMA_e4b74d26-4df4-41ee-be37-79988ed530ad">P5Y1M13D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="i4246c537469d483abd783cecc40379d0_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtNS0xLTEtMA_253c1a56-65ec-4120-8287-d8c6d7cca605"
      unitRef="usdPerShare">74.42</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="i4246c537469d483abd783cecc40379d0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtNy0xLTEtMA_0bb4eb5c-fa58-400a-82f1-1219de7da05d"
      unitRef="shares">190825</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="i4246c537469d483abd783cecc40379d0_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzgtOS0xLTEtMA_5c7c0f5f-4ca6-4f63-8211-55f1642afeba"
      unitRef="usdPerShare">74.42</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktMS0xLTEtMA_4ca3032d-4f81-4e2b-9d6f-e26cb2c25ea5"
      unitRef="shares">299282</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i239d27b3ec29423f9178131cc573bbe6_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktMy0xLTEtMA_b12501e3-6ea5-4508-93b6-ae0507c00048">P7Y6M25D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktNS0xLTEtMA_b2297c5e-525a-445a-8541-70ae1b29543d"
      unitRef="usdPerShare">93.32</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktNy0xLTEtMA_d8a2c2ad-194c-4d3a-aec4-7e326a579d46"
      unitRef="shares">157872</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="i5974c3104a5d4b21bf3baa514858efa2_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzktOS0xLTEtMA_32db895c-9109-41f3-80bf-12d39468bdb3"
      unitRef="usdPerShare">91.62</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTEtMS0xLTA_062387dc-9e55-4db1-b1e7-9c7323dcd5c5"
      unitRef="shares">353006</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i9b8e1917f5d44958bdedd8df35f11dc5_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTMtMS0xLTA_1cdf7b00-eb75-486f-8daf-7a0279c57161">P8Y9M14D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTUtMS0xLTA_d56874df-7f7e-4fcf-854e-c51243b20550"
      unitRef="usdPerShare">148.50</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTctMS0xLTA_7a05ca30-d117-40b0-b85e-0a1dcd9adf51"
      unitRef="shares">96064</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="icd529d0655ba4752b67e7314f7cc06f6_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzEwLTktMS0xLTA_0858d52a-482e-4a8f-a9cc-21d34a3b5158"
      unitRef="usdPerShare">131.77</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions
      contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTEtMS0xLTA_08b7b253-aa18-4419-8e54-b33ef7e31730"
      unitRef="shares">1734304</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2
      contextRef="i358fc37bf7e448078b5305d7b8438a37_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTMtMS0xLTA_cf192bca-5013-4d43-9b91-0dd1c3dcc9d0">P5Y5M19D</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1
      contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTUtMS0xLTA_ac46b05c-75da-4a35-a746-244d93506033"
      unitRef="usdPerShare">66.71</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1>
    <us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions
      contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTctMS0xLTA_a01dcb72-d5bd-4161-a72f-33beb8cbbbab"
      unitRef="shares">1313374</us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions>
    <us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1
      contextRef="icf71bbc4ad954da9bce0e233b086c8bb_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTpiOWM1MjEwZDg2YjM0YTFiYjc4MTYxZmQ3ZTMwMjc3NS90YWJsZXJhbmdlOmI5YzUyMTBkODZiMzRhMWJiNzgxNjFmZDdlMzAyNzc1XzExLTktMS0xLTA_25d96541-6064-435d-9926-1528b5b5ffff"
      unitRef="usdPerShare">47.03</us-gaap:SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1>
    <us-gaap:ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDE_001bdf31-90bb-4754-bc87-9d2944eea56e">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.538012%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:51.709199%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.986944%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.541840%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:12.540059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.541840%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="18" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Risk-free interest rate&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.7%-3.0%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.0%-2.2%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.3%-1.9%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expected volatility&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33%-36%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;43%-47%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;48%-50%&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expected term&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5.1 to 5.8 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6.5 to 6.8 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6.6 to 6.7 years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock>
    <us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions
      contextRef="ia0d63b23666041d7a8b08537e54a6d2c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzEyMzk_4f8b1f26-770c-4be0-bed1-20cb4617045a"
      unitRef="usd">20400000</us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions>
    <us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
      contextRef="i28700ea37c214b3e8041db8c7f28f9d0_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzEzOTM_f6e6adfc-562b-424a-b501-a6ae3445a132">P2Y4M20D</us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1>
    <us-gaap:ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1Xzk4OTU2MDQ2NTU2NDA_c46a9ec7-1c86-4a23-8f5f-e0d300f330a7">&lt;div style="margin-top:5pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following is a summary of our restricted stock activity and related information:&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:71.127753%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.628488%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.534214%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:11.509545%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Shares&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Weighted-Average&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Grant&#160;Date Fair&lt;/span&gt;&lt;/div&gt;&lt;div style="text-align:center;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;"&gt;Value&lt;/span&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Outstanding at December&#160;31, 2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;133,294&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;91.60&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Granted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;62,133&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;169.92&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Vested&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(61,989)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;86.19&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Forfeited&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,165)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;125.16&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Outstanding at December&#160;31, 2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;132,273&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;130.63&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber
      contextRef="id920233585164484842655792fe0311e_I20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzEtMS0xLTEtMA_47dd5363-45d0-4712-be56-0775fc0c6395"
      unitRef="shares">133294</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
      contextRef="id920233585164484842655792fe0311e_I20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzEtMy0xLTEtMA_a382e64b-e0ab-44c4-adc5-6dec35a2f8e9"
      unitRef="usdPerShare">91.60</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzItMS0xLTEtMA_a3cc9c52-63b7-4d6e-83ba-67011823915d"
      unitRef="shares">62133</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzItMy0xLTEtMA_4ab1e231-3f38-4b88-935d-7b588237d824"
      unitRef="usdPerShare">169.92</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzMtMS0xLTEtMA_7864abb5-107e-4c9b-b353-fb0c731cd4e4"
      unitRef="shares">61989</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzMtMy0xLTEtMA_21ab5464-5cd7-451f-b7f7-a4400999ff7a"
      unitRef="usdPerShare">86.19</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzQtMS0xLTEtMA_0ee22e4e-93e3-4eb2-8f5d-efed0eab10f6"
      unitRef="shares">1165</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzQtMy0xLTEtMA_8557694a-c68e-4562-b596-db014df3499d"
      unitRef="usdPerShare">125.16</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber
      contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzUtMS0xLTEtMA_8f214703-7178-45d1-a57f-db5d9a984238"
      unitRef="shares">132273</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
      contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90YWJsZTo0NDMxNjkxMWQ5MjU0NzAxOWU3MjU0MTE1ZTE5ZmJkMy90YWJsZXJhbmdlOjQ0MzE2OTExZDkyNTQ3MDE5ZTcyNTQxMTVlMTlmYmQzXzUtMy0xLTEtMA_e4278283-b006-4b4b-8194-9f6cb73b2f49"
      unitRef="usdPerShare">130.63</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue>
    <us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions
      contextRef="ia8daa835bec54c7c91c9c0efb2a892d6_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE2MTQ_9b3a348b-92b9-4d5a-bf20-238a32b35017"
      unitRef="usd">9200000</us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions>
    <us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
      contextRef="iaead0586e66545bf9a546304d06af27d_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE2OTE_6b4ce40b-1b17-4218-b721-38126b61d3f2">P1Y4M17D</us-gaap:EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
      contextRef="i5049cfdd90d748e48259538705c3a2a0_I20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE3NjE_ff878e6f-1057-4e80-ad76-67bed1182219"
      unitRef="shares">64008</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee
      contextRef="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzE5NDg_da5a36ec-18d3-42d5-9802-45d42a3d5631"
      unitRef="shares">1250</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod
      contextRef="i7dbca0127b8c4fd4aa87c6d2c860766d_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNDg_91efb899-a98e-44be-b387-30ec4b1bd65e"
      unitRef="shares">3386</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod
      contextRef="ic36cfb515c93422e90d0bdcd8bd0ebee_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNTI_25ee3fa1-e855-4c9f-9cd9-ba98b52afb6b"
      unitRef="shares">3061</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
    <us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod
      contextRef="i6ec79fc5ae034975bdc7a82825400a68_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIyNTk_28abb155-6fff-4967-90fa-a37c047bbdd4"
      unitRef="shares">1961</us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyMjE_69309b25-4255-4eaf-bb62-3a6a4359ff3d"
      unitRef="shares">260000</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:AcceleratedShareRepurchasesFinalPricePaidPerShare
      contextRef="ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNDY_ebedcc6d-b652-453e-95a5-129195256f7d"
      unitRef="usdPerShare">191.14</us-gaap:AcceleratedShareRepurchasesFinalPricePaidPerShare>
    <us-gaap:StockRepurchaseProgramAuthorizedAmount1
      contextRef="ibb568ab64b614ed6a1e37b60e92b6fef_I20150930"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyMzA_a893af4e-f1f1-41ae-8090-87b9b41b3865"
      unitRef="usd">200000000.0</us-gaap:StockRepurchaseProgramAuthorizedAmount1>
    <us-gaap:StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNTU_3f553585-5a4c-49e6-924a-2701c042490a"
      unitRef="usd">125200000</us-gaap:StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1>
    <us-gaap:StockRepurchaseProgramAuthorizedAmount1
      contextRef="if2c884f969ea4a8c957cc0b0ecc3ad55_I20190123"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjEyNzI_ae4f0c45-6b87-490b-a39c-d65fadb1a528"
      unitRef="usd">350000000.0</us-gaap:StockRepurchaseProgramAuthorizedAmount1>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="i0f29d3370c15467eae1d22610a661a7f_D20190101-20190228"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjIzMTE_c07c86d8-f2a1-45b3-8291-77c60b9fd34f"
      unitRef="shares">400177</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchaseProgramAuthorizedAmount1
      contextRef="ia523a50a3e1f4636a3f2c5181779d8ee_I20190228"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzIxOTkwMjMyNjIzMjU_9c66a7ae-64fb-44ce-84d8-09b8bdbfd9ff"
      unitRef="usd">225900000</us-gaap:StockRepurchaseProgramAuthorizedAmount1>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI0MjA_24e158fd-0b94-4163-888b-e169146fd8f0"
      unitRef="shares">782248</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzI0MzQ_c9f487b4-7fb0-4314-ba4e-c66302a8a215"
      unitRef="usd">127500000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxODM_09a043b8-fe78-4797-9774-c9b13c438199"
      unitRef="shares">14000</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxOTU_ce062c3a-1f51-460f-806d-5b6f9da844ad"
      unitRef="usd">2000000.0</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:StockRepurchasedDuringPeriodShares
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="INF"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxODc_4193c9c7-21a0-42f4-bd0e-f979371c0f34"
      unitRef="shares">40500</us-gaap:StockRepurchasedDuringPeriodShares>
    <us-gaap:StockRepurchasedDuringPeriodValue
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF80ODIvZnJhZzoyMGE1YmE1MDkwYjY0MTlhOGNiNjMwMDYwZDM2MDIyNS90ZXh0cmVnaW9uOjIwYTViYTUwOTBiNjQxOWE4Y2I2MzAwNjBkMzYwMjI1XzM4NDgyOTA3MDAxOTI_2ab3cd16-e24a-4723-93a8-503e9b1719db"
      unitRef="usd">3900000</us-gaap:StockRepurchasedDuringPeriodValue>
    <us-gaap:LegalMattersAndContingenciesTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MDcvZnJhZzo0OTczMWY0YmY4ZWU0ZWQ2YmI4Mjk2ZmJhYjdjOTRjZC90ZXh0cmVnaW9uOjQ5NzMxZjRiZjhlZTRlZDZiYjgyOTZmYmFiN2M5NGNkXzk4OTU2MDQ2NTgyMTU_34d09888-f9c3-4719-8b15-85da84e64e7e">Commitment and Contingencies: Legal Proceedings&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We record an estimate of a loss when the loss is considered probable and estimable. Where a liability is probable and there is a range of estimated loss and no amount in the range is more likely than any other number in the range, we record the minimum estimated liability related to the claim in accordance with &lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;"&gt;ASC 450, Contingencies&lt;/span&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;. As additional information becomes available, we assess the potential liability related to our pending litigation and revises our estimates. Revisions in the our estimates of potential liability could materially impact our results of operations.&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;On July 27, 2018, AG Oncon, LLC, AG Ofcon, Ltd., Calamos Market Neutral Income Fund, Capital Ventures International, Citadel Equity Fund Ltd., Opti Opportunity Master Fund, Polygon Convertible Opportunity Master Fund, Wolverine Flagship Fund Trading Limited, as plaintiffs, filed a complaint in the Court of Chancery of the State of Delaware (AG Oncon, LLC v. Ligand Pharmaceuticals Inc.) alleging claims for violation of the Trust Indenture Act, breach of contract, damages and a declaratory judgment that the Supplemental Indenture, dated as of February 20, 2018, entered into by us and Wilmington Trust, National Association, as trustee, is invalid. On October 1, 2018, we filed a motion to dismiss the plaintiffs&#x2019; complaint. The hearing on our motion is currently scheduled for April 3, 2019. We believe the allegations are completely without merit, reject all claims raised by the plaintiffs and intend to vigorously defend this matter.&lt;/span&gt;&lt;/div&gt;In November 2017, CyDex, our wholly owned subsidiary, received a paragraph IV certification from Teva alleging that certain of our patents related to Captisol were invalid, unenforceable and/or will not be infringed by Teva&#x2019;s ANDA related to Spectrum Pharmaceuticals&#x2019; NDA for Evomela. On December 20, 2017, CyDex filed a complaint against Teva in the U.S. District Court for the District of Delaware, asserting that Teva&#x2019;s ANDA would infringe our patents. On March 22, 2018, Teva filed an answer and counterclaims seeking declarations of non-infringement and invalidity as to each of the asserted patents and on April 12, 2018, CyDex filed an answer to Teva&#x2019;s counterclaims. On July 24, 2018, the U.S. District Court entered a Scheduling Order, setting a hearing for April 1, 2019, and a trial may begin in January 2020.</us-gaap:LegalMattersAndContingenciesTextBlock>
    <us-gaap:IncomeTaxDisclosureTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0ODU_547c9311-1dda-4913-ba0e-5ce6d7105f04">Income Taxes&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The Tax Act was enacted on December 22, 2017 and includes a number of changes to existing tax laws that impact us, most notably it reduces the US federal corporate tax rate from 35% to 21%, for tax years beginning after December 31, 2017.&#160;The Tax Act made modifications to allowable tax depreciation, the deductability of compensation for officers, the deductibility of meals and entertainment expenses, and the deductibility of interest expense. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We remeasured our deferred tax assets and liabilities based on the impact of the federal tax rate change, recording a decrease to our net deferred tax asset balance and a corresponding increase to our income tax provision of approximately&#160;$0.6 million&#160;and $32.4 million&#160;for the year ended December 31, 2018&#160;and 2017, respectively.  We completed our accounting for the Tax Act during the fourth quarter of 2018. &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The components of the income tax expense (benefit) for continuing operations are as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.976608%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:65.503693%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.833973%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.686263%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Current expense (benefit):&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Federal&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;424&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;111&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Foreign&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(158)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;261&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;266&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred expense (benefit):&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Federal&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,928&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,075&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,534&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(185)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;228&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(240)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Foreign&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,009&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,675&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,327&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of income tax expense (benefit) from continuing operations to the amount computed by applying the statutory federal income tax rate to the net income (loss) from continuing operations is summarized as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:65.941176%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.682353%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Tax at federal statutory rate&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,031&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,786&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State, net of federal benefit&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,635&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;622&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;175&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Contingent liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;948&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;903&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,225&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Share-based compensation&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(8,131)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,019)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;263&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research and development credits&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,758)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,821)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,525)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in uncertain tax positions&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;858&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,308&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,423&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Rate change for changes in federal or state law&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;178&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;32,429&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;25&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in valuation allowance&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,225)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,169)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,283&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expired NOLs and credits&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,054&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in derivatives&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;615&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,435&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;391&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(328)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,009&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,675&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,327&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We remeasured certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which is generally 21%. &#160;Significant components of our deferred tax assets and liabilities as of December&#160;31, 2018 and 2017 are shown below. We assess the positive and negative evidence to determine if sufficient future taxable income will be generated to use the existing deferred tax assets. Our evaluation of evidence resulted in management concluding that the majority of our&#160;deferred tax assets will be realized.  However, we maintain a valuation allowance to offset certain net deferred tax assets as management believes realization of such assets are uncertain as of December&#160;31, 2018, 2017 and 2016. The valuation allowance decreased $2.5 million in 2018, decreased $8.4 million in 2017 and increased $6.3 million in 2016.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.175439%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:74.958525%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.059908%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.568049%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.213518%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(in thousands)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred tax assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net operating loss carryforwards&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;57,181&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;90,272&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research credit carryforwards&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;31,101&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,677&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fixed assets and intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,637&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,984&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Accrued expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;657&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;845&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred revenue&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;957&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Capital Loss Carryforward&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,609&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,137&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11,430&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,499&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;102,963&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;143,040&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Valuation allowance for deferred tax assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,476)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(6,987)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net deferred tax assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;98,487&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;136,053&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred tax liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Retrophin fair value adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(179)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(243)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Convertible debt&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,905)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(737)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Identified intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(44,643)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(48,237)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Identified indefinite lived intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,759)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,414)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,480)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net deferred tax liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(51,966)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(51,631)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred income taxes, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,521&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;84,422&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;As of December&#160;31, 2018, we had federal net operating loss carryforwards set to expire through 2037 of $229.9 million and $125.3 million of state net operating loss carryforwards. We also have&#160;$23.0 million of federal research and development credit carryforwards, which expire through 2037. We have&#160;$22.7 million of California research and development credit carryforwards that have no expiration date.&#160;&#160; &lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Pursuant to Section 382 and 383 of the Internal Revenue Code of 1986, as amended, utilization of our net operating losses and credits may be subject to annual limitations in the event of any significant future changes in its ownership structure. These annual limitations may result in the expiration of net operating losses and credits prior to utilization. The deferred tax assets as of December 31, 2018 are net of any previous limitations due to Section 382 and 383.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We account for income taxes by evaluating a probability threshold that a tax position must meet before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position. Our remaining liabilities for uncertain tax positions are presented net of the deferred tax asset balances on the accompanying consolidated balance sheet.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of the amount of unrecognized tax benefits at December&#160;31, 2018, 2017 and 2016 is as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.029240%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:64.769231%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.461538%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.569231%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.461538%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.569231%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.769231%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at beginning of year&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,363&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,770&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,452&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Additions based on tax positions related to the current year&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,247&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,067&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;70&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Additions for tax positions of prior years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;336&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;109&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,408&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Reductions for tax positions of prior years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(657)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,583)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(160)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at end of year&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,289&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,363&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,770&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;&lt;div style="text-indent:24pt;"&gt;&lt;span&gt;&lt;br/&gt;&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;Included in the balance of unrecognized tax benefits at December&#160;31, 2018 is $28.2 million of tax benefits that, if recognized would impact the effective rate. There are no positions for which it is reasonably possible that the uncertain tax benefit will significantly increase or decrease within twelve months.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;We recognize interest and penalties related to uncertain tax positions in income tax expense.  As of December&#160;31, 2018 and December&#160;31, 2017, we recognized an immaterial amount of interest and penalties. We file income tax returns in the United States, various state jurisdictions, United Kingdom, and Canada with varying statutes of limitations. The federal statute of limitation remains open for the 2014 tax year to the present.&#160;The state income tax returns generally remain open for the 2013 tax year through the present.&#160; Net operating loss and research credit carryforwards arising prior to these years are also open to examination if and when utilized.&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The IRS began an audit of our 2016 tax year during the quarter ended June 30, 2018. We believe our reserve for unrecognized tax benefits and contingent tax issues is adequate with respect to all open years. Notwithstanding the foregoing, we could adjust our provision for income taxes and contingent tax liability based on future developments.&lt;/span&gt;&lt;/div&gt;</us-gaap:IncomeTaxDisclosureTextBlock>
    <lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0OTc1NTgyNjE2Mg_07522b1e-4b46-429a-8f63-ddfa06107f63"
      unitRef="usd">600000</lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit>
    <lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzU0OTc1NTgxNTEyMDY_1815bf73-9203-4d56-af3d-d4080325a387"
      unitRef="usd">32400000</lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit>
    <us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMjM_65c854ce-fd69-474f-b1b5-dfd9aca58cd9">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The components of the income tax expense (benefit) for continuing operations are as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.976608%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:65.503693%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.833973%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.686263%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.192024%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Current expense (benefit):&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Federal&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;424&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;111&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Foreign&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(158)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;261&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;266&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;372&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred expense (benefit):&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Federal&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,928&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,075&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,534&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(185)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;228&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(240)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Foreign&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,009&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,675&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,327&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock>
    <us-gaap:CurrentFederalTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMS0xLTEtODcwNQ_85b1dd12-ad44-474a-9aa8-cc086e76a791"
      unitRef="usd">0</us-gaap:CurrentFederalTaxExpenseBenefit>
    <us-gaap:CurrentFederalTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMS0xLTEtMA_4060c872-aeb6-4555-94e9-f0eea1b4e9b0"
      unitRef="usd">0</us-gaap:CurrentFederalTaxExpenseBenefit>
    <us-gaap:CurrentFederalTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzMtMy0xLTEtMA_97065934-ec69-47d3-a675-0d1eadfdd4d7"
      unitRef="usd">21000</us-gaap:CurrentFederalTaxExpenseBenefit>
    <us-gaap:CurrentStateAndLocalTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMS0xLTEtODcwNw_836c1484-e82e-4a84-b3f7-00bc4c71e834"
      unitRef="usd">424000</us-gaap:CurrentStateAndLocalTaxExpenseBenefit>
    <us-gaap:CurrentStateAndLocalTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMS0xLTEtMA_2d3b9a15-a734-4fa1-87d3-eccb7642beb8"
      unitRef="usd">111000</us-gaap:CurrentStateAndLocalTaxExpenseBenefit>
    <us-gaap:CurrentStateAndLocalTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzQtMy0xLTEtMA_d5bc6587-8685-4e09-a461-3396d2f710a6"
      unitRef="usd">12000</us-gaap:CurrentStateAndLocalTaxExpenseBenefit>
    <us-gaap:CurrentForeignTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtMS0xLTEtODcwOQ_e9425a15-ad1d-4b3b-a60d-9aefc04bf77d"
      unitRef="usd">-158000</us-gaap:CurrentForeignTaxExpenseBenefit>
    <us-gaap:CurrentForeignTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtMS0xLTEtMA_c23f609f-b5ec-4589-b273-e404855a3100"
      unitRef="usd">261000</us-gaap:CurrentForeignTaxExpenseBenefit>
    <us-gaap:CurrentForeignTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzUtNS0xLTEtODcwMg_5cb222af-e8f6-45e1-a101-94a1f6e88d75"
      unitRef="usd">0</us-gaap:CurrentForeignTaxExpenseBenefit>
    <us-gaap:CurrentIncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMS0xLTEtODcxMQ_25c3fb38-15f9-4af4-9907-91b77fb5ed29"
      unitRef="usd">266000</us-gaap:CurrentIncomeTaxExpenseBenefit>
    <us-gaap:CurrentIncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMS0xLTEtMA_c0104f56-05e9-4bf8-84be-d9c03340f785"
      unitRef="usd">372000</us-gaap:CurrentIncomeTaxExpenseBenefit>
    <us-gaap:CurrentIncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzYtMy0xLTEtMA_2d067fef-1e7d-492d-9bdf-d883257dd30c"
      unitRef="usd">33000</us-gaap:CurrentIncomeTaxExpenseBenefit>
    <us-gaap:DeferredFederalIncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMS0xLTEtODcxMw_96346def-63cf-46ae-880a-e686abd33c98"
      unitRef="usd">29928000</us-gaap:DeferredFederalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredFederalIncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMS0xLTEtMA_3234f63c-e334-41ce-8dc1-d10c765372ad"
      unitRef="usd">44075000</us-gaap:DeferredFederalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredFederalIncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzgtMy0xLTEtMA_535af49e-9bca-4cb6-ad22-d661476f1cb7"
      unitRef="usd">10534000</us-gaap:DeferredFederalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMS0xLTEtODcxNQ_c631dff5-f906-48bb-8a41-61ab13606ebc"
      unitRef="usd">-185000</us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMS0xLTEtMA_a7adb7b4-4beb-485a-842f-f1a03f7bbbbd"
      unitRef="usd">228000</us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzktMy0xLTEtMA_04c95f38-0479-459f-ba52-76a140c364e7"
      unitRef="usd">-240000</us-gaap:DeferredStateAndLocalIncomeTaxExpenseBenefit>
    <us-gaap:DeferredForeignIncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTEtMS0xLTg3MTc_12664b97-c7ff-4066-964a-e6ba21d87259"
      unitRef="usd">0</us-gaap:DeferredForeignIncomeTaxExpenseBenefit>
    <us-gaap:DeferredForeignIncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTEtMS0xLTA_9afa459b-23b8-41bc-84bd-2443c4902c96"
      unitRef="usd">0</us-gaap:DeferredForeignIncomeTaxExpenseBenefit>
    <us-gaap:DeferredForeignIncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzEwLTMtMS0xLTA_f1cd708e-641f-441a-8324-b530963094ab"
      unitRef="usd">0</us-gaap:DeferredForeignIncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTEtMS0xLTg3MTk_c158d929-342b-4bda-bbc6-12fab366a0f0"
      unitRef="usd">30009000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTEtMS0xLTA_f2e24dad-619b-4cbc-99c8-f9b9a18b9df7"
      unitRef="usd">44675000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTplNzkyZDQyOTQzZTk0MGE3OWY4ZWUxNTFmMTBmYWUyOC90YWJsZXJhbmdlOmU3OTJkNDI5NDNlOTQwYTc5ZjhlZTE1MWYxMGZhZTI4XzExLTMtMS0xLTA_2bf04b08-b8b2-4ace-a2fe-a85c8180a742"
      unitRef="usd">10327000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMjk_930ce2ee-e607-47fa-84dd-ff04323b9351">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of income tax expense (benefit) from continuing operations to the amount computed by applying the statutory federal income tax rate to the net income (loss) from continuing operations is summarized as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;"&gt;&#160;&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:65.941176%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.535294%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.682353%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.147059%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Year Ended December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Tax at federal statutory rate&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,400&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,031&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,786&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;State, net of federal benefit&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,635&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;622&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;175&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Contingent liabilities&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;948&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;903&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,225&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Share-based compensation&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(8,131)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,019)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;263&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research and development credits&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,758)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,821)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,525)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in uncertain tax positions&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;858&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,308&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,423&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Rate change for changes in federal or state law&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;178&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;32,429&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;25&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in valuation allowance&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,225)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,169)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,283&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Expired NOLs and credits&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3,054&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Change in derivatives&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;615&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,435&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;391&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(328)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,009&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;44,675&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;10,327&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock>
    <us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMS0xLTEtNjI3Mg_2adf5668-95c9-414c-804a-8e55b3b17fe1"
      unitRef="usd">36400000</us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate>
    <us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMS0xLTEtMA_107fbcb4-1b30-4247-a52d-bf62115580d6"
      unitRef="usd">20031000</us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate>
    <us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzItMy0xLTEtMA_6828216a-3049-4c3b-9df3-54eae13dedd9"
      unitRef="usd">2786000</us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate>
    <us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMS0xLTEtNjI4Mg_954d5533-540e-473d-82e7-6165880e9bf4"
      unitRef="usd">1635000</us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes>
    <us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMS0xLTEtMA_508acc0b-9fbd-44c5-8a14-f61ba1dfeb53"
      unitRef="usd">622000</us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes>
    <us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzMtMy0xLTEtMA_8f62bc00-f286-465c-838a-3bc5e1a1538c"
      unitRef="usd">175000</us-gaap:IncomeTaxReconciliationStateAndLocalIncomeTaxes>
    <lgnd:IncomeTaxReconciliationContingentValueRights
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMS0xLTEtNjI4Ng_4cbd1100-3ffa-4e57-a6e6-2e1d5f2a7e0d"
      unitRef="usd">948000</lgnd:IncomeTaxReconciliationContingentValueRights>
    <lgnd:IncomeTaxReconciliationContingentValueRights
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMS0xLTEtMA_1ad5324a-309b-4fb5-bb1b-e719139dca1f"
      unitRef="usd">903000</lgnd:IncomeTaxReconciliationContingentValueRights>
    <lgnd:IncomeTaxReconciliationContingentValueRights
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzQtMy0xLTEtMA_a40d38de-6559-40f6-a372-136107ef8a22"
      unitRef="usd">1225000</lgnd:IncomeTaxReconciliationContingentValueRights>
    <us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMS0xLTEtNjI5MQ_0f768d80-384e-4e72-ab91-81a4b52539df"
      unitRef="usd">-8131000</us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost>
    <us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMS0xLTEtMA_6eaef243-b3a1-4d65-9b74-53b1d5ceef88"
      unitRef="usd">-4019000</us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost>
    <us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzUtMy0xLTEtMA_e037b3c0-5585-4633-9e14-93ea4b79c772"
      unitRef="usd">263000</us-gaap:IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost>
    <lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMS0xLTEtNjI5NA_c9fb1f28-adf0-4999-8c14-4040598a27f1"
      unitRef="usd">-2758000</lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch>
    <lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMS0xLTEtMA_d2bc4a66-a8c6-4ed2-ad59-13cb2d746557"
      unitRef="usd">-2821000</lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch>
    <lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzYtMy0xLTEtMA_464bb01b-b53f-44ae-985b-2ecbc569123d"
      unitRef="usd">-1525000</lgnd:IncomeTaxReconciliationExpiredTaxCreditsResearch>
    <lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMS0xLTEtNjI5OA_17d0039a-145e-4b25-8ab7-1f0d9face552"
      unitRef="usd">-858000</lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions>
    <lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMS0xLTEtMA_0fe105ae-3cc9-4e26-a1f7-987209353af7"
      unitRef="usd">-1308000</lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions>
    <lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzctMy0xLTEtMA_fe0c251c-137c-4d7d-b335-6b75e7f6ae22"
      unitRef="usd">-1423000</lgnd:IncomeTaxReconciliationChangeInUncertainTaxPositions>
    <us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMS0xLTEtNjMwMQ_b66b2623-dae8-48ca-83e8-a938d8ae3e23"
      unitRef="usd">178000</us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate>
    <us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMS0xLTEtMA_24764b6d-3a9c-4dd3-86a5-d87b1d656c8f"
      unitRef="usd">32429000</us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate>
    <us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzgtMy0xLTEtMA_a5e85590-9898-4358-8034-75b25d7876aa"
      unitRef="usd">25000</us-gaap:IncomeTaxReconciliationChangeInEnactedTaxRate>
    <us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMS0xLTEtNjMwNQ_defe7c90-68d2-4910-926e-5a0bba01788b"
      unitRef="usd">-4225000</us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance>
    <us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMS0xLTEtMA_38a0c0c1-4e34-4a50-900d-4f7091afd90d"
      unitRef="usd">-4169000</us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance>
    <us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzktMy0xLTEtMA_1d1a430d-d891-4139-9502-d8df8e15fd5f"
      unitRef="usd">6283000</us-gaap:IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance>
    <us-gaap:IncomeTaxReconciliationTaxCreditsOther
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTIxMjgy_7925ac21-60c6-4086-a12f-2416266b376c"
      unitRef="usd">-3054000</us-gaap:IncomeTaxReconciliationTaxCreditsOther>
    <us-gaap:IncomeTaxReconciliationTaxCreditsOther
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTMtMS0xLTIxNDM1_f252d33e-744d-4e90-bf16-ebeb0263d088"
      unitRef="usd">0</us-gaap:IncomeTaxReconciliationTaxCreditsOther>
    <us-gaap:IncomeTaxReconciliationTaxCreditsOther
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTUtMS0xLTIxNDM3_5a5fad73-7661-4154-870f-1924f65264cf"
      unitRef="usd">0</us-gaap:IncomeTaxReconciliationTaxCreditsOther>
    <lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTIxMjg2_1a6b71bd-19a2-4e39-83f2-2de2ec41f852"
      unitRef="usd">615000</lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives>
    <lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTMtMS0xLTIxNDMz_1c779846-1007-44ea-995f-64880f3b6933"
      unitRef="usd">0</lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives>
    <lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTUtMS0xLTIxNDM5_9177867a-fd0e-4f1c-a12f-3698594f39bf"
      unitRef="usd">0</lgnd:EffectiveIncomeTaxRateReconciliationChangeInDerivatives>
    <us-gaap:IncomeTaxReconciliationOtherAdjustments
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTYzMDg_17f19c78-ee84-4f30-886e-04c0a2078d15"
      unitRef="usd">1435000</us-gaap:IncomeTaxReconciliationOtherAdjustments>
    <us-gaap:IncomeTaxReconciliationOtherAdjustments
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTEtMS0xLTA_094966f3-9c68-4a64-a299-3d8e60c54b20"
      unitRef="usd">391000</us-gaap:IncomeTaxReconciliationOtherAdjustments>
    <us-gaap:IncomeTaxReconciliationOtherAdjustments
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzEwLTMtMS0xLTA_b85d761c-d42b-48f3-a7e6-fa2749803c43"
      unitRef="usd">-328000</us-gaap:IncomeTaxReconciliationOtherAdjustments>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTg3MzI_f36530d1-1e41-4ee4-954f-2a2219ff1b67"
      unitRef="usd">30009000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTEtMS0xLTA_ab513020-90ad-45c5-bb63-6dbcbc9269e4"
      unitRef="usd">44675000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTowZDkwMjhjYjI1NmY0YmEwODBmMjk1YWE0YmQyMjIzMy90YWJsZXJhbmdlOjBkOTAyOGNiMjU2ZjRiYTA4MGYyOTVhYTRiZDIyMjMzXzExLTMtMS0xLTA_a9cd072e-435c-4d67-af1d-68f9219a395d"
      unitRef="usd">10327000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMzg_3fbbc41b-b794-43a0-888d-ac9f59410038">Significant components of our deferred tax assets and liabilities as of December&#160;31, 2018 and 2017 are shown below. We assess the positive and negative evidence to determine if sufficient future taxable income will be generated to use the existing deferred tax assets. Our evaluation of evidence resulted in management concluding that the majority of our&#160;deferred tax assets will be realized.  However, we maintain a valuation allowance to offset certain net deferred tax assets as management believes realization of such assets are uncertain as of December&#160;31, 2018, 2017 and 2016. The valuation allowance decreased $2.5 million in 2018, decreased $8.4 million in 2017 and increased $6.3 million in 2016.&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.175439%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:74.958525%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.059908%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.568049%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:9.213518%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December&#160;31,&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(in thousands)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred tax assets:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net operating loss carryforwards&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;57,181&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;90,272&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Research credit carryforwards&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;31,101&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,677&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fixed assets and intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,637&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,984&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Accrued expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;657&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;845&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred revenue&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;957&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;17&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Capital Loss Carryforward&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,609&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,137&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Other&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;11,430&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;12,499&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;102,963&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;143,040&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Valuation allowance for deferred tax assets&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(4,476)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(6,987)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net deferred tax assets&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;98,487&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;136,053&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred tax liabilities:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Retrophin fair value adjustment&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(179)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(243)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Convertible debt&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,905)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(737)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Identified intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(44,643)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(48,237)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Identified indefinite lived intangibles&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,759)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,414)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Investment in Viking&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,480)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#x2014;&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net deferred tax liabilities&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(51,966)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(51,631)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Deferred income taxes, net&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;46,521&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;84,422&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;</us-gaap:ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock>
    <us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzM4NDgyOTA3MDQzNDI_f2562391-264a-4d18-9e60-bbec61bf27ea"
      unitRef="usd">-2500000</us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
    <us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzI5NjE_f77d9ea4-75e9-4b3c-ae68-1835db882e12"
      unitRef="usd">-8400000</us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
    <us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzI5ODM_07a54193-4fb2-47df-8dbc-925646473cee"
      unitRef="usd">6300000</us-gaap:ValuationAllowanceDeferredTaxAssetChangeInAmount>
    <us-gaap:DeferredTaxAssetsOperatingLossCarryforwards
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzQtMS0xLTEtMA_c46b0aff-3c84-4728-a06b-11c42dd4fe3b"
      unitRef="usd">57181000</us-gaap:DeferredTaxAssetsOperatingLossCarryforwards>
    <us-gaap:DeferredTaxAssetsOperatingLossCarryforwards
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzQtMy0xLTEtMA_462b7f5c-fd6d-48c0-9c27-1d7829b2e700"
      unitRef="usd">90272000</us-gaap:DeferredTaxAssetsOperatingLossCarryforwards>
    <us-gaap:DeferredTaxAssetsTaxCreditCarryforwards
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzUtMS0xLTEtMA_a0ac560c-2f37-413d-bbfc-19468c3583d9"
      unitRef="usd">31101000</us-gaap:DeferredTaxAssetsTaxCreditCarryforwards>
    <us-gaap:DeferredTaxAssetsTaxCreditCarryforwards
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzUtMy0xLTEtMA_c7208675-c6c5-494a-942b-389cb4904583"
      unitRef="usd">30677000</us-gaap:DeferredTaxAssetsTaxCreditCarryforwards>
    <lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzYtMS0xLTEtMA_1abb9486-971e-47f5-a730-70549e27032b"
      unitRef="usd">1637000</lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets>
    <lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzYtMy0xLTEtMA_70af7cbb-bd48-45c9-9840-de038d07367f"
      unitRef="usd">1984000</lgnd:DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets>
    <us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzctMS0xLTEtMA_d5bdcfe9-940a-4a5f-9014-8649f7357bc5"
      unitRef="usd">657000</us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities>
    <us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzctMy0xLTEtMA_b100b896-3be8-4175-b6bc-3e69ed3ed14d"
      unitRef="usd">845000</us-gaap:DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities>
    <us-gaap:DeferredTaxAssetsDeferredIncome
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzktMS0xLTEtMA_8bef427b-e8ac-4606-b4bd-03d6e25fdda6"
      unitRef="usd">957000</us-gaap:DeferredTaxAssetsDeferredIncome>
    <us-gaap:DeferredTaxAssetsDeferredIncome
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzktMy0xLTEtMA_6e8e3ddf-c5d0-41c0-adaf-ef672931fcec"
      unitRef="usd">17000</us-gaap:DeferredTaxAssetsDeferredIncome>
    <us-gaap:DeferredTaxAssetsCapitalLossCarryforwards
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEyLTEtMS0xLTA_6dfc3c6a-83d6-4e49-a8cb-193d71903e64"
      unitRef="usd">0</us-gaap:DeferredTaxAssetsCapitalLossCarryforwards>
    <us-gaap:DeferredTaxAssetsCapitalLossCarryforwards
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEyLTMtMS0xLTA_33cd9d18-ad80-457d-acca-0bb17732a734"
      unitRef="usd">1609000</us-gaap:DeferredTaxAssetsCapitalLossCarryforwards>
    <us-gaap:DeferredTaxAssetsEquityMethodInvestments
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEzLTEtMS0xLTA_5f8ffa84-db31-41ab-942e-9a4f74723ed4"
      unitRef="usd">0</us-gaap:DeferredTaxAssetsEquityMethodInvestments>
    <us-gaap:DeferredTaxAssetsEquityMethodInvestments
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzEzLTMtMS0xLTA_af80a011-de31-4c59-81af-a3f58248176e"
      unitRef="usd">5137000</us-gaap:DeferredTaxAssetsEquityMethodInvestments>
    <us-gaap:DeferredTaxAssetsOther
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE0LTEtMS0xLTA_638e78d1-7d00-421c-b836-b61a2bf124db"
      unitRef="usd">11430000</us-gaap:DeferredTaxAssetsOther>
    <us-gaap:DeferredTaxAssetsOther
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE0LTMtMS0xLTA_60f3a345-00ad-4f8b-8a28-2c245c9d5224"
      unitRef="usd">12499000</us-gaap:DeferredTaxAssetsOther>
    <us-gaap:DeferredTaxAssetsGross
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE1LTEtMS0xLTA_df8179ba-923f-41e4-9570-cc5af1ee0576"
      unitRef="usd">102963000</us-gaap:DeferredTaxAssetsGross>
    <us-gaap:DeferredTaxAssetsGross
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE1LTMtMS0xLTA_591e865d-3b78-458b-9660-62c5d3e02530"
      unitRef="usd">143040000</us-gaap:DeferredTaxAssetsGross>
    <us-gaap:DeferredTaxAssetsValuationAllowance
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE2LTEtMS0xLTA_e4e3c6cb-eeca-4f75-b5b9-e8801389cc63"
      unitRef="usd">4476000</us-gaap:DeferredTaxAssetsValuationAllowance>
    <us-gaap:DeferredTaxAssetsValuationAllowance
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE2LTMtMS0xLTA_d411ddde-c2fc-418b-bbb6-6df88b804bce"
      unitRef="usd">6987000</us-gaap:DeferredTaxAssetsValuationAllowance>
    <us-gaap:DeferredTaxAssetsNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE3LTEtMS0xLTA_4d3e6634-bf99-4a02-b9b4-377a373dd079"
      unitRef="usd">98487000</us-gaap:DeferredTaxAssetsNet>
    <us-gaap:DeferredTaxAssetsNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE3LTMtMS0xLTA_d1bdf4e6-ade2-4658-ab68-c54be22ae18f"
      unitRef="usd">136053000</us-gaap:DeferredTaxAssetsNet>
    <lgnd:DeferredTaxLiabilitiesFairValueAdjustment
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE5LTEtMS0xLTA_8711950e-4c75-404b-9d0b-f719f950017e"
      unitRef="usd">179000</lgnd:DeferredTaxLiabilitiesFairValueAdjustment>
    <lgnd:DeferredTaxLiabilitiesFairValueAdjustment
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzE5LTMtMS0xLTA_f0116818-ff5c-4f01-acf2-e9af6b70545c"
      unitRef="usd">243000</lgnd:DeferredTaxLiabilitiesFairValueAdjustment>
    <us-gaap:DeferredTaxLiabilitiesFinancingArrangements
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTEtMS0xLTA_113f2423-d95a-4729-bfab-a4e4b01864c2"
      unitRef="usd">2905000</us-gaap:DeferredTaxLiabilitiesFinancingArrangements>
    <us-gaap:DeferredTaxLiabilitiesFinancingArrangements
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTMtMS0xLTA_e3eee678-9727-4f42-afaf-fb560b3b63e4"
      unitRef="usd">737000</us-gaap:DeferredTaxLiabilitiesFinancingArrangements>
    <lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIxLTEtMS0xLTA_13a23a05-ddb4-4250-9547-53c063331f12"
      unitRef="usd">44643000</lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets>
    <lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIxLTMtMS0xLTA_dc0bcac0-43c8-4172-b935-c6a7481bac04"
      unitRef="usd">48237000</lgnd:DeferredTaxLiabilitiesFiniteLivedIntangibleAssets>
    <lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTEtMS0xLTA_77e81461-8547-44f7-ac42-887c9879f14f"
      unitRef="usd">1759000</lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets>
    <lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTMtMS0xLTA_fcd31bfd-689e-4c18-98b6-b12f01a52fa6"
      unitRef="usd">2414000</lgnd:DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets>
    <us-gaap:DeferredTaxLiabilitiesInvestments
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTEtMS0xLTYzNzU_d8f79ed2-c402-4697-96b8-8e6bff14161d"
      unitRef="usd">2480000</us-gaap:DeferredTaxLiabilitiesInvestments>
    <us-gaap:DeferredTaxLiabilitiesInvestments
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIwLTMtMS0xLTg4MDQ_bbcd312c-13fb-4bcf-9d09-a0af10b22c9b"
      unitRef="usd">0</us-gaap:DeferredTaxLiabilitiesInvestments>
    <us-gaap:DeferredIncomeTaxLiabilities
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTEtMS0xLTIxNDQx_609e440b-9e3e-43bc-8962-e67e28af3503"
      unitRef="usd">51966000</us-gaap:DeferredIncomeTaxLiabilities>
    <us-gaap:DeferredIncomeTaxLiabilities
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIyLTMtMS0xLTIxNDQz_3df98f80-7be5-4207-bbf4-2aced7a314ae"
      unitRef="usd">51631000</us-gaap:DeferredIncomeTaxLiabilities>
    <us-gaap:DeferredTaxAssetsLiabilitiesNet
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTEtMS0xLTA_14cd34b6-4627-4b8f-aa07-187260f0c159"
      unitRef="usd">46521000</us-gaap:DeferredTaxAssetsLiabilitiesNet>
    <us-gaap:DeferredTaxAssetsLiabilitiesNet
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTo1MDk3ZGUyNmVjNDA0NDBlOTE0MDllMDNmZjdjZDhkMS90YWJsZXJhbmdlOjUwOTdkZTI2ZWM0MDQ0MGU5MTQwOWUwM2ZmN2NkOGQxXzIzLTMtMS0xLTA_e09268fa-a45b-417d-8f5e-488aa81534c9"
      unitRef="usd">84422000</us-gaap:DeferredTaxAssetsLiabilitiesNet>
    <us-gaap:OperatingLossCarryforwards
      contextRef="ie84f0fb144ed4ec5926cfdf7ba32b2bb_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMxMzA_c23502d7-b28e-47fd-9baf-4b7b78e2e491"
      unitRef="usd">229900000</us-gaap:OperatingLossCarryforwards>
    <us-gaap:OperatingLossCarryforwards
      contextRef="if81fb0e1a8ac48909d921d4552f44684_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMxMzc_f63cc76b-98d9-4946-a4eb-201be174c651"
      unitRef="usd">125300000</us-gaap:OperatingLossCarryforwards>
    <us-gaap:TaxCreditCarryforwardAmount
      contextRef="ib8f1f80b43fe48948dc666b8a2639468_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMyMDQ_efb32d81-d905-48dd-a019-ec86c123bc67"
      unitRef="usd">23000000.0</us-gaap:TaxCreditCarryforwardAmount>
    <us-gaap:TaxCreditCarryforwardAmount
      contextRef="i1426778bb59d4208adce54ccb7e0983f_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzMzMDY_7fe64bdb-db7b-442c-a1d6-eedee3c86463"
      unitRef="usd">22700000</us-gaap:TaxCreditCarryforwardAmount>
    <us-gaap:ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5Xzk4OTU2MDQ2NjAzMzk_de097127-ba6b-42d5-8087-100e2375d732">&lt;div style="margin-top:9pt;"&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;A reconciliation of the amount of unrecognized tax benefits at December&#160;31, 2018, 2017 and 2016 is as follows (in thousands):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.029240%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:64.769231%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.461538%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.569231%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.461538%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.569231%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:8.769231%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;December 31,&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2016&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at beginning of year&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,363&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,770&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;36,452&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Additions based on tax positions related to the current year&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,247&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1,067&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;70&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Additions for tax positions of prior years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;336&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;109&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2,408&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Reductions for tax positions of prior years&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(657)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,583)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(160)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Balance at end of year&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;30,289&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,363&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;38,770&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItMS0xLTEtMA_7c56449a-4a90-493a-960b-ac4c660fb38a"
      unitRef="usd">29363000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItMy0xLTEtMA_8d1e6d6e-0a4c-4be3-878d-8505a7ad19e6"
      unitRef="usd">38770000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="ib4c3c6fac973483badc44a66252c9222_I20151231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzItNS0xLTEtMA_1dc0bab5-ca6d-4161-8b9b-c741e9261006"
      unitRef="usd">36452000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtMS0xLTEtMA_9363564d-869d-41ed-b293-0c5ad70e9e71"
      unitRef="usd">1247000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtMy0xLTEtMA_1da0ec23-b976-4cc3-aa80-c86596abc51f"
      unitRef="usd">1067000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzMtNS0xLTEtMA_5b330613-a6ad-44bc-af13-bd6e36b66a8a"
      unitRef="usd">70000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtMS0xLTEtMA_27280b3d-dd79-4cbf-ba96-22eac10ced0b"
      unitRef="usd">336000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtMy0xLTEtMA_44a7cc12-627c-44d0-8665-463afa2d1890"
      unitRef="usd">109000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzQtNS0xLTEtMA_f2cfaa84-1fdd-49c2-bb53-e4cec65beaef"
      unitRef="usd">2408000</us-gaap:UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtMS0xLTEtMA_30fd288d-d818-44b1-843d-0f566840d032"
      unitRef="usd">657000</us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
      contextRef="i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtMy0xLTEtMA_87586920-5c2c-4336-a969-1bc9fbfd438b"
      unitRef="usd">10583000</us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
      contextRef="i2ec9f22a045a4527ad98e4be212ef057_D20160101-20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzUtNS0xLTEtMA_00d262a5-9c43-43d4-93c9-053988858d9a"
      unitRef="usd">160000</us-gaap:UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtMS0xLTEtMA_70d1d768-14fd-4b8e-8d8f-cd9f3c42940d"
      unitRef="usd">30289000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtMy0xLTEtMA_6aec27f1-24e9-4b6f-a47b-d1376aa4301d"
      unitRef="usd">29363000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefits
      contextRef="ia2d1a8eee1564d08a05108a7d9f42143_I20161231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90YWJsZTpkZTM5NjUzODIzYzE0YTVmYTYwZGI2ODlhNTI5ZWZiMS90YWJsZXJhbmdlOmRlMzk2NTM4MjNjMTRhNWZhNjBkYjY4OWE1MjllZmIxXzYtNS0xLTEtMA_c2237c0a-69fc-4ca0-90ed-d351f59bf287"
      unitRef="usd">38770000</us-gaap:UnrecognizedTaxBenefits>
    <us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate
      contextRef="i87420e1b166545afb11eefa8eb1ab74c_I20181231"
      decimals="-5"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MTkvZnJhZzpmYjBlNmI4Y2VkNjI0YjNmYTY0NTE1MGUwZmY1ZGJkOS90ZXh0cmVnaW9uOmZiMGU2YjhjZWQ2MjRiM2ZhNjQ1MTUwZTBmZjVkYmQ5XzQ2MjE_e616864e-3f7b-4125-bdc1-4e6b09bef96a"
      unitRef="usd">28200000</us-gaap:UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate>
    <us-gaap:QuarterlyFinancialInformationTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90ZXh0cmVnaW9uOjFiZjRmNmZkYWFlNTQ0ZmQ4MDVkNmMxZDg4MmUyYTQyXzk4OTU2MDQ2NTAzNTg_cbb50369-86f7-4ca9-9e02-b31f95efc74a">Summary of Unaudited Quarterly Financial Information&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results and cash flows of interim periods. Summarized quarterly data for 2018 and 2017 are as follows (in thousands, except per share amounts):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;First Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Second Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt; Third Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fourth Quarter&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total revenues&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56,157&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;90,043&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;45,663&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;59,590&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating costs and expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,116&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,868&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,301&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,441&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Income tax (expense) benefit&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,033)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(22,419)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(11,864)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,307&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;45,279&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;73,160&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67,362&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(42,482)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Basic per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.13&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.45&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.19&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2.02)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Diluted per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.83&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.99&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.80&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2.02)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;basic&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,209&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,212&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,148&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;diluted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,800&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,438&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,052&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total revenues&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,267&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,995&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33,375&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50,465&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating costs and expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,051&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,980&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16,882&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,113&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Income tax expense&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,114)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,242)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,645)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(37,674)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,079&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,058&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,426&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(7,007)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Basic per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.24&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.29&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(0.33)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Diluted per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.22&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.26&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(0.33)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;basic&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,938&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,013&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,109&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;diluted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,019&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,216&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,109&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:QuarterlyFinancialInformationTextBlock>
    <us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock
      contextRef="id13a97144b904710b9835494780d5820_D20180101-20181231"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90ZXh0cmVnaW9uOjFiZjRmNmZkYWFlNTQ0ZmQ4MDVkNmMxZDg4MmUyYTQyXzk4OTU2MDQ2NTAzNTk_e8290a35-237c-4628-9ae5-e2c79ca01829">&lt;div&gt;&lt;span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"&gt;The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results and cash flows of interim periods. Summarized quarterly data for 2018 and 2017 are as follows (in thousands, except per share amounts):&lt;/span&gt;&lt;/div&gt;&lt;div style="margin-bottom:6pt;"&gt;&lt;table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"&gt;&lt;tr&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:45.128130%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:0.536377%;"/&gt;&lt;td style="width:0.1%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;td style="width:10.665685%;"/&gt;&lt;td style="width:1.0%;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;First Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Second Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt; Third Quarter&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Fourth Quarter&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2018&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total revenues&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;56,157&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;90,043&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;45,663&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;59,590&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating costs and expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,116&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,868&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,301&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;26,441&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Income tax (expense) benefit&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(10,033)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(22,419)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(11,864)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,307&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;td colspan="3" style="display:none;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;45,279&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;73,160&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;67,362&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(42,482)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Basic per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.13&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.45&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;3.19&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2.02)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Diluted per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;     Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;1.83&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.99&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2.80&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2.02)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;basic&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,209&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,212&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,148&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;diluted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,800&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,438&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;24,052&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;2017&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total revenues&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;29,267&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;27,995&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;33,375&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;50,465&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Total operating costs and expenses&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;19,051&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;14,980&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;16,882&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;22,113&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Income tax expense&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(1,114)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(2,242)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(3,645)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(37,674)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;5,079&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;6,058&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;8,426&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(7,007)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Basic per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.24&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.29&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.40&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(0.33)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Diluted per share amounts:&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Net income (loss)&lt;/span&gt;&lt;/td&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.22&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.26&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;0.36&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;$&lt;/span&gt;&lt;/td&gt;&lt;td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;(0.33)&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;basic&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;20,938&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,013&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,071&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,109&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;Weighted average shares&#x2014;diluted&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,019&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,216&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;23,551&#160;&lt;/span&gt;&lt;/td&gt;&lt;td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/&gt;&lt;td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"&gt;&lt;span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"&gt;21,109&#160;&lt;/span&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/table&gt;&lt;/div&gt;</us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItMS0xLTEtMA_c5b6487c-0cc0-4863-a7db-e48bbf892d66"
      unitRef="usd">56157000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItMy0xLTEtMA_e0f52162-ddd4-4bb8-b615-b3a9504e5366"
      unitRef="usd">90043000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItNS0xLTEtMA_77eabb24-e830-4273-a9de-3a2323a65d47"
      unitRef="usd">45663000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzItNy0xLTEtMA_4e4767df-48fc-4040-8f29-8910fa0247b8"
      unitRef="usd">59590000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtMS0xLTEtMA_34f24aa2-b6b0-4927-ac84-72bb30421397"
      unitRef="usd">19116000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtMy0xLTEtMA_38ee773e-293d-4aff-a305-2e4144ea3fc4"
      unitRef="usd">19868000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtNS0xLTEtMA_7941a475-cef8-4cbd-9d2f-9129c4e4f9cc"
      unitRef="usd">22301000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzMtNy0xLTEtMA_43ac6efc-3665-4791-a6f2-76dd9484969d"
      unitRef="usd">26441000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtMS0xLTEtMA_2de3c1f9-cd13-4527-bd97-751e1a550135"
      unitRef="usd">10033000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtMy0xLTEtMA_99585706-4c32-4769-b74e-d828e49f7ccb"
      unitRef="usd">22419000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtNS0xLTEtMA_7177d5d7-a18d-4ff2-8656-d00a3701b733"
      unitRef="usd">11864000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzQtNy0xLTEtMA_c20dec29-a0c9-45b2-88c0-f9efe7a6719d"
      unitRef="usd">-14307000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:NetIncomeLoss
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtMS0xLTEtMA_5a8e812e-bbe2-4f7b-b577-30794b6f19dd"
      unitRef="usd">45279000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtMy0xLTEtMA_75eeb1c2-3941-4601-a314-e6061273e128"
      unitRef="usd">73160000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtNS0xLTEtMA_00806710-1a99-4122-b4de-9ba3c1bb1075"
      unitRef="usd">67362000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzgtNy0xLTEtMA_d58ee9ea-5654-4198-92ea-f263a5ba039e"
      unitRef="usd">-42482000</us-gaap:NetIncomeLoss>
    <us-gaap:EarningsPerShareBasic
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTEtMS0xLTA_32d95318-6d47-42cd-ada4-aba756f83ab5"
      unitRef="usdPerShare">2.13</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTMtMS0xLTA_af4e93e6-1653-4fb5-a47e-23e0326d6326"
      unitRef="usdPerShare">3.45</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTUtMS0xLTA_103ba0cd-10ac-4dc0-8795-9ac14cdc3077"
      unitRef="usdPerShare">3.19</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEwLTctMS0xLTA_e76fb894-0662-4843-974b-64e198d39249"
      unitRef="usdPerShare">-2.02</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTEtMS0xLTA_6e8d1f71-2c8b-4f30-bad8-dbfa9dbe1d3a"
      unitRef="usdPerShare">1.83</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTMtMS0xLTA_0987015d-1112-4ca0-b4c1-6bb009750cce"
      unitRef="usdPerShare">2.99</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTUtMS0xLTA_c5fd65a1-b4f2-4014-8854-ea02cfbe64d6"
      unitRef="usdPerShare">2.80</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzEyLTctMS0xLTA_392964ba-3d23-404b-bbfc-39283cba17ae"
      unitRef="usdPerShare">-2.02</us-gaap:EarningsPerShareDiluted>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTEtMS0xLTA_f73691a6-18b3-475f-ae07-80fb23116bc0"
      unitRef="shares">21209000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTMtMS0xLTA_1f45013b-823e-4b17-9fe2-499048ec1714"
      unitRef="shares">21212000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTUtMS0xLTA_1196ca94-e539-478b-9b7d-c95068e1214e"
      unitRef="shares">21148000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE0LTctMS0xLTA_4dab20a6-4e35-4aef-bb72-00af91c10dd0"
      unitRef="shares">21071000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i9c14afec25f14ea987c4eca4a7931fb8_D20170101-20170331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTEtMS0xLTA_00188fdf-2c5e-40d6-a853-cc9fe6fbc8d6"
      unitRef="shares">24800000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i629fd315f0344d618e896741a9894704_D20170401-20170630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTMtMS0xLTA_8c5b3c21-cbdf-491d-b886-a4760e25c8e6"
      unitRef="shares">24438000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i9807b2d5b13a4faaab0662e544aa7fca_D20170701-20170930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTUtMS0xLTA_16cb1d58-225b-43ac-9ac5-c1a620b5c45f"
      unitRef="shares">24052000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i32f9937bb05f4ae3803659a88d077a23_D20171001-20171231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE1LTctMS0xLTA_a2c4c7a0-ca50-4bdc-b023-1697df08464d"
      unitRef="shares">21071000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTEtMS0xLTA_a5a2c105-faf0-41b7-aa2f-9edaa393bb4c"
      unitRef="usd">29267000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTMtMS0xLTA_6f01f666-3ede-435e-8995-2a4a872288d0"
      unitRef="usd">27995000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTUtMS0xLTA_72df081c-8b41-46a8-87f3-c2e8c1aef250"
      unitRef="usd">33375000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE4LTctMS0xLTA_a5082f5b-0c73-4c10-af03-b3629ebb8b86"
      unitRef="usd">50465000</us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTEtMS0xLTA_623910c3-141d-4195-9147-3911c9565bab"
      unitRef="usd">19051000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTMtMS0xLTA_fa09226c-3eb3-46b8-ab23-08421f404a1f"
      unitRef="usd">14980000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTUtMS0xLTA_66682c0c-b384-4d13-b500-3cde94ea28a0"
      unitRef="usd">16882000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:OperatingCostsAndExpenses
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzE5LTctMS0xLTA_6851dbe1-a9fc-46b3-a9c2-53834b0ed60c"
      unitRef="usd">22113000</us-gaap:OperatingCostsAndExpenses>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTEtMS0xLTA_3d516052-2ef7-463a-ac1d-4c1e81dc5455"
      unitRef="usd">1114000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTMtMS0xLTA_143bea88-4fbc-4b6f-a09c-3a1a8cd1dd1f"
      unitRef="usd">2242000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTUtMS0xLTA_811227e3-e354-4bc5-af77-edf69a3b84e2"
      unitRef="usd">3645000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:IncomeTaxExpenseBenefit
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIwLTctMS0xLTA_65845698-41c9-4aed-913e-fca62bb2ceb6"
      unitRef="usd">37674000</us-gaap:IncomeTaxExpenseBenefit>
    <us-gaap:NetIncomeLoss
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTEtMS0xLTA_aac47116-e8bd-4709-b3e0-c4552eed885b"
      unitRef="usd">5079000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTMtMS0xLTA_35e4e348-d47b-4a71-85bf-7dcd4df0f86e"
      unitRef="usd">6058000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTUtMS0xLTA_6f0ae70d-d19a-4db2-b26c-c01c1fd73a2f"
      unitRef="usd">8426000</us-gaap:NetIncomeLoss>
    <us-gaap:NetIncomeLoss
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIxLTctMS0xLTA_d62c7598-004d-4740-83a9-422cc89d8545"
      unitRef="usd">-7007000</us-gaap:NetIncomeLoss>
    <us-gaap:EarningsPerShareBasic
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTEtMS0xLTA_09306152-7ea0-402d-9299-852f2961f32f"
      unitRef="usdPerShare">0.24</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTMtMS0xLTA_6a80e477-3b7c-4b2a-8360-524bc7cf2845"
      unitRef="usdPerShare">0.29</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTUtMS0xLTA_aadaa2c1-9860-4bf9-9382-a0564d416bdf"
      unitRef="usdPerShare">0.40</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareBasic
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzIzLTctMS0xLTA_fd388af8-bf01-4a76-a39c-f800f6ab0a53"
      unitRef="usdPerShare">-0.33</us-gaap:EarningsPerShareBasic>
    <us-gaap:EarningsPerShareDiluted
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTEtMS0xLTA_fbc768b9-0406-4f5d-9032-89a0068a4b13"
      unitRef="usdPerShare">0.22</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTMtMS0xLTA_05f065fe-1f71-496b-a858-d5b3fff70385"
      unitRef="usdPerShare">0.26</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTUtMS0xLTA_061eba63-96f2-4d71-a2ed-bb3b0a2827df"
      unitRef="usdPerShare">0.36</us-gaap:EarningsPerShareDiluted>
    <us-gaap:EarningsPerShareDiluted
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="2"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI1LTctMS0xLTA_90f55a03-5cdb-4f76-932e-9dc999a95d5f"
      unitRef="usdPerShare">-0.33</us-gaap:EarningsPerShareDiluted>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTEtMS0xLTA_26221837-da1c-4518-910d-06bc72805e9a"
      unitRef="shares">20938000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTMtMS0xLTA_0f09267f-9430-4da7-938b-eff8cab64b1d"
      unitRef="shares">21013000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTUtMS0xLTA_73571307-bd4b-4794-bf01-8fedc094cd1a"
      unitRef="shares">21071000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfSharesOutstandingBasic
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI3LTctMS0xLTA_227a6ce0-7253-46f1-8911-c9e77d6331f8"
      unitRef="shares">21109000</us-gaap:WeightedAverageNumberOfSharesOutstandingBasic>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="ief940d953eac4033875ea91ff5566b14_D20180101-20180331"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTEtMS0xLTA_08dcb08a-8068-4c1f-a689-2f13053ca22d"
      unitRef="shares">23019000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="if3202f58bee349d3a9c993316dde67e4_D20180401-20180630"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTMtMS0xLTA_2bfa1ec5-50e0-42c8-814c-a4425da9ac86"
      unitRef="shares">23216000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i4368a6b5585841d18c9e17ad7ee34c67_D20180701-20180930"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTUtMS0xLTA_4507715e-27c6-43d8-a64f-70636aca738f"
      unitRef="shares">23551000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding
      contextRef="i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231"
      decimals="-3"
      id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF81MzEvZnJhZzoxYmY0ZjZmZGFhZTU0NGZkODA1ZDZjMWQ4ODJlMmE0Mi90YWJsZTpmZjQ5MzlmNjBjYjI0N2ZiYmQ0NzBmNDNkNTE0MTk4MC90YWJsZXJhbmdlOmZmNDkzOWY2MGNiMjQ3ZmJiZDQ3MGY0M2Q1MTQxOTgwXzI4LTctMS0xLTA_3fd5ae73-a884-47f4-9e8b-37a4541153a9"
      unitRef="shares">21109000</us-gaap:WeightedAverageNumberOfDilutedSharesOutstanding>
    <link:footnoteLink
      xlink:role="http://www.xbrl.org/2003/role/link"
      xlink:type="extended">
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b"
          xlink:type="locator"/>
        <link:loc
          xlink:href="#id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8"
          xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8"
          xlink:type="locator"/>
        <link:footnote id="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62" xlink:label="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62" xlink:role="http://www.xbrl.org/2003/role/footnote" xlink:type="resource" xml:lang="en-US">The sum of net income per share amounts may not equal the total due to rounding</link:footnote>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTUtMS0xLTA_99e71174-e17b-4462-9299-a9458646e4eb"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTUtMS0xLTA_1cc4df06-abf1-4388-857b-bb4c02ba9658"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTEtMS0xLTA_e02de236-c573-4cc7-a262-60c1374002a7"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTEtMS0xLTA_c99362dc-eead-44fd-b6c9-b1d1fdb5c424"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTUtMS0xLTA_8787025f-516c-4e18-aaa5-c9e69ab6c4a6"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM0LTMtMS0xLTA_acb4ef12-2bab-4f67-9fbe-3e404f54fd5a"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTUtMS0xLTA_c8394460-da1b-47dd-8c8f-d8477291b8c6"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTEtMS0xLTA_2fb21de0-d205-4602-90bc-a80acdc18988"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTUtMS0xLTA_c7a5cf76-1a9c-4628-b674-6e8b3f647668"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTEtMS0xLTA_e46d8bdc-6aaf-415b-8982-3793a8c6317b"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM5LTMtMS0xLTA_accfbf22-0f39-46a1-bc29-a56210787da5"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTEtMS0xLTA_d00fd571-d5db-4bcc-b993-d041ca149cb8"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTUtMS0xLTA_ff942b9f-a65f-4cf7-9da1-54efcf04622a"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM1LTMtMS0xLTA_d5607833-94a6-4778-a9c4-169cfd0eaca0"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTEtMS0xLTA_989b1c5a-697e-4ce8-8db1-b8393761e5c1"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzQwLTMtMS0xLTA_277b907e-bd5d-4a8a-a90d-ca0d8acf384a"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzM4LTMtMS0xLTA_d0da751c-357c-48d7-bd0d-fd29db598648"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
        <link:footnoteArc
          xlink:arcrole="http://www.xbrl.org/2003/arcrole/fact-footnote"
          xlink:from="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90YWJsZTo2YzI5YzczNjlmN2M0NmZkYjBjY2YwMTFiZGI0ODQwNi90YWJsZXJhbmdlOjZjMjljNzM2OWY3YzQ2ZmRiMGNjZjAxMWJkYjQ4NDA2XzMzLTMtMS0xLTA_3e684d00-8382-4f19-a119-71227bd789b0"
          xlink:to="id3VybDovL2RvY3MudjEvZG9jOmQ4NmQ4YjhlMzZlOTQ5NTg4MzRjMDYyNzEyNTM5NTVkL3NlYzpkODZkOGI4ZTM2ZTk0OTU4ODM0YzA2MjcxMjUzOTU1ZF8yOTcvZnJhZzo2NjJkYzRlMDM2ZGI0MmFmOTIzMmJjNjI1NzM5MmE5NS90ZXh0cmVnaW9uOjY2MmRjNGUwMzZkYjQyYWY5MjMyYmM2MjU3MzkyYTk1XzMyMA_5550fa31-235d-45fa-826c-d72bc7f5ba62"
          xlink:type="arc"/>
    </link:footnoteLink>
</xbrl>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>16
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6898584176">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Document and Entity Information - USD ($)<br> $ in Billions</strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Feb. 25, 2019</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DocumentAndEntityInformationAbstract', window );"><strong>Document and Entity Information [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">LIGAND PHARMACEUTICALS INC<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0000886163<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">10-K<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Dec. 31,  2018<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentFiscalYearFocus', window );">Document Fiscal Year Focus</a></td>
<td class="text">2018<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentFiscalPeriodFocus', window );">Document Fiscal Period Focus</a></td>
<td class="text">FY<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_CurrentFiscalYearEndDate', window );">Current Fiscal Year End Date</a></td>
<td class="text">--12-31<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityFilerCategory', window );">Entity Filer Category</a></td>
<td class="text">Large Accelerated Filer<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntitySmallBusiness', window );">Entity Small Business</a></td>
<td class="text">false<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityShellCompany', window );">Entity Shell Company</a></td>
<td class="text">false<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityCommonStockSharesOutstanding', window );">Entity Common Stock, Shares Outstanding</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20,445,407<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityPublicFloat', window );">Entity Public Float</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 3.6<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityVoluntaryFilers', window );">Entity Voluntary Filers</a></td>
<td class="text">No<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityWellKnownSeasonedIssuer', window );">Entity Well-Known Seasoned Issuer</a></td>
<td class="text">Yes<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityCurrentReportingStatus', window );">Entity Current Reporting Status</a></td>
<td class="text">Yes<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>If the value is true, then the document is an amendment to previously-filed/accepted document.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CurrentFiscalYearEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>End date of current fiscal year in the format --MM-DD.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CurrentFiscalYearEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:gMonthDayItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentFiscalPeriodFocus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>This is focus fiscal period of the document report. For a first quarter 2006 quarterly report, which may also provide financial information from prior periods, the first fiscal quarter should be given as the fiscal period focus. Values: FY, Q1, Q2, Q3, Q4, H1, H2, M9, T1, T2, T3, M8, CY.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentFiscalPeriodFocus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fiscalPeriodItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentFiscalYearFocus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>This is focus fiscal year of the document report in CCYY format. For a 2006 annual report, which may also provide financial information from prior periods, fiscal 2006 should be given as the fiscal year focus. Example: 2006.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentFiscalYearFocus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:gYearItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The end date of the period reflected on the cover page if a periodic report. For all other reports and registration statements containing historical data, it is the date up through which that historical data is presented.  If there is no historical data in the report, use the filing date. The format of the date is CCYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCommonStockSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate number of shares or other units outstanding of each of registrant's classes of capital or common stock or other ownership interests, if and as stated on cover of related periodic report. Where multiple classes or units exist define each class/interest by adding class of stock items such as Common Class A [Member], Common Class B [Member] or Partnership Interest [Member] onto the Instrument [Domain] of the Entity Listings, Instrument.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCommonStockSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCurrentReportingStatus">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' whether registrants (1) have filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that registrants were required to file such reports), and (2) have been subject to such filing requirements for the past 90 days. This information should be based on the registrant's current or most recent filing containing the related disclosure.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCurrentReportingStatus</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFilerCategory">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate whether the registrant is one of the following: (1) Large Accelerated Filer, (2) Accelerated Filer, (3) Non-accelerated Filer, (4) Smaller Reporting Company (Non-accelerated), (5) Smaller Reporting Accelerated Filer or (6) Smaller Reporting Company and Large Accelerated Filer. Definitions of these categories are stated in Rule 12b-2 of the Exchange Act. This information should be based on the registrant's current or most recent filing containing the related disclosure.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFilerCategory</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:filerCategoryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityPublicFloat">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>State aggregate market value of voting and non-voting common equity held by non-affiliates computed by reference to price at which the common equity was last sold, or average bid and asked price of such common equity, as of the last business day of registrant's most recently completed second fiscal quarter. The public float should be reported on the cover page of the registrants form 10K.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityPublicFloat</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityShellCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate if company meets the shell company criteria: a company with no or nominal operations, and with no or nominal assets or assets consisting solely of cash and cash equivalents.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityShellCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntitySmallBusiness">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicates that the company is a smaller reporting company with both a public float and revenues of less than $75 million.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntitySmallBusiness</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityVoluntaryFilers">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityVoluntaryFilers</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityWellKnownSeasonedIssuer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate 'Yes' or 'No' if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Is used on Form Type: 10-K, 10-Q, 8-K, 20-F, 6-K, 10-K/A, 10-Q/A, 20-F/A, 6-K/A, N-CSR, N-Q, N-1A.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityWellKnownSeasonedIssuer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:yesNoItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DocumentAndEntityInformationAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Document and entity information.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DocumentAndEntityInformationAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>17
<FILENAME>R2.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6899034320">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>CONSOLIDATED BALANCE SHEETS - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsCurrentAbstract', window );"><strong>Current assets:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CashAndCashEquivalentsAtCarryingValue', window );">Cash and cash equivalents</a></td>
<td class="nump">$ 117,164<span></span>
</td>
<td class="nump">$ 20,620<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShortTermInvestments', window );">Short-term investments</a></td>
<td class="nump">601,217<span></span>
</td>
<td class="nump">181,041<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquitySecuritiesFvNi', window );">Investment in Viking</a></td>
<td class="nump">46,191<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ReceivablesNetCurrent', window );">Accounts receivable, net</a></td>
<td class="nump">55,850<span></span>
</td>
<td class="nump">25,596<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NotesAndLoansReceivableGrossCurrent', window );">Note receivable from Viking</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">3,877<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InventoryNet', window );">Inventory</a></td>
<td class="nump">7,124<span></span>
</td>
<td class="nump">4,373<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeAssetsCurrent', window );">Derivative asset</a></td>
<td class="nump">22,576<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherAssetsCurrent', window );">Other current assets</a></td>
<td class="nump">20,418<span></span>
</td>
<td class="nump">1,514<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsCurrent', window );">Total current assets</a></td>
<td class="nump">870,540<span></span>
</td>
<td class="nump">237,021<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredIncomeTaxAssetsNet', window );">Deferred income taxes, net</a></td>
<td class="nump">46,521<span></span>
</td>
<td class="nump">84,422<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquityMethodInvestments', window );">Investment in Viking</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">6,438<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IntangibleAssetsNetExcludingGoodwill', window );">Intangible assets, net</a></td>
<td class="nump">219,793<span></span>
</td>
<td class="nump">228,584<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="nump">86,646<span></span>
</td>
<td class="nump">85,959<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CommercialLicenseRights', window );">Commercial license rights</a></td>
<td class="nump">31,460<span></span>
</td>
<td class="nump">19,526<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentNet', window );">Property and equipment, net</a></td>
<td class="nump">5,372<span></span>
</td>
<td class="nump">4,212<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherAssetsNoncurrent', window );">Other assets</a></td>
<td class="nump">471<span></span>
</td>
<td class="nump">4,859<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Assets', window );">Total assets</a></td>
<td class="nump">1,260,803<span></span>
</td>
<td class="nump">671,021<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesCurrentAbstract', window );"><strong>Current liabilities:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccountsPayableCurrent', window );">Accounts payable</a></td>
<td class="nump">4,183<span></span>
</td>
<td class="nump">2,259<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccruedLiabilitiesCurrent', window );">Accrued liabilities</a></td>
<td class="nump">19,200<span></span>
</td>
<td class="nump">7,377<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CurrentPortionOfLiabilityForContingentValueRights', window );">Current contingent liabilities</a></td>
<td class="nump">5,717<span></span>
</td>
<td class="nump">4,703<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ContractWithCustomerLiabilityCurrent', window );">Deferred revenue</a></td>
<td class="nump">3,286<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilitiesCurrent', window );">Derivative liability</a></td>
<td class="nump">23,430<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConvertibleDebtCurrent', window );">2019 convertible senior notes, net</a></td>
<td class="nump">26,433<span></span>
</td>
<td class="nump">224,529<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesCurrent', window );">Total current liabilities</a></td>
<td class="nump">82,249<span></span>
</td>
<td class="nump">238,868<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConvertibleDebtNoncurrent', window );">2023 convertible senior notes, net</a></td>
<td class="nump">609,864<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_LiabilityForContingentValueRights', window );">Long-term contingent liabilities</a></td>
<td class="nump">6,825<span></span>
</td>
<td class="nump">9,258<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherLiabilitiesNoncurrent', window );">Other long-term liabilities</a></td>
<td class="nump">951<span></span>
</td>
<td class="nump">4,248<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Liabilities', window );">Total liabilities</a></td>
<td class="nump">699,889<span></span>
</td>
<td class="nump">252,374<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommitmentsAndContingencies', window );">Commitments and contingencies</a></td>
<td class="text"> <span></span>
</td>
<td class="text"> <span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Equity component of currently redeemable convertible notes (Note 6)</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">18,859<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityAbstract', window );"><strong>Stockholders&#8217; equity:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockValue', window );">Common stock, $0.001 par value; 60,000,000 and 33,333,333 shares authorized; 20,765,533 and 21,148,665 shares issued and outstanding at December&#160;31, 2018 and 2017, respectively</a></td>
<td class="nump">21<span></span>
</td>
<td class="nump">21<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdditionalPaidInCapital', window );">Additional paid-in capital</a></td>
<td class="nump">791,114<span></span>
</td>
<td class="nump">798,205<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax', window );">Accumulated other comprehensive income (loss)</a></td>
<td class="num">(1,024)<span></span>
</td>
<td class="nump">2,486<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RetainedEarningsAccumulatedDeficit', window );">Accumulated deficit</a></td>
<td class="num">(229,197)<span></span>
</td>
<td class="num">(400,924)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquity', window );">Total stockholders&#8217; equity</a></td>
<td class="nump">560,914<span></span>
</td>
<td class="nump">399,788<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesAndStockholdersEquity', window );">Total liabilities and stockholders&#8217; equity</a></td>
<td class="nump">$ 1,260,803<span></span>
</td>
<td class="nump">$ 671,021<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CommercialLicenseRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Commercial License Rights</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CommercialLicenseRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CurrentPortionOfLiabilityForContingentValueRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Current portion of liability for contingent value rights.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CurrentPortionOfLiabilityForContingentValueRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_LiabilityForContingentValueRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Liability for contingent value rights.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_LiabilityForContingentValueRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccountsPayableCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.19(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccountsPayableCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccruedLiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccruedLiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=d3e637-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14A<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669686-108580<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=d3e681-108580<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdditionalPaidInCapital">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Excess of issue price over par or stated value of the entity's capital stock and amounts received from other transactions involving the entity's stock or stockholders. Includes adjustments to additional paid in capital. Some examples of such adjustments include recording the issuance of debt with a beneficial conversion feature and certain tax consequences of equity instruments awarded to employees. Use this element for the aggregate amount of additional paid-in capital associated with common and preferred stock. For additional paid-in capital associated with only common stock, use the element additional paid in capital, common stock. For additional paid-in capital associated with only preferred stock, use the element additional paid in capital, preferred stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(30)(a)(1))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdditionalPaidInCapital</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Assets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Sum of the carrying amounts as of the balance sheet date of all assets that are recognized. Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(11))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(12))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Assets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AssetsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Sum of the carrying amounts as of the balance sheet date of all assets that are expected to be realized in cash, sold, or consumed within one year (or the normal operating cycle, if longer). Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6801-107765<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.9)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AssetsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AssetsCurrentAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AssetsCurrentAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CashAndCashEquivalentsAtCarryingValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3044-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.1)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CashAndCashEquivalentsAtCarryingValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommitmentsAndContingencies">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Represents the caption on the face of the balance sheet to indicate that the entity has entered into (1) purchase or supply arrangements that will require expending a portion of its resources to meet the terms thereof, and (2) is exposed to potential losses or, less frequently, gains, arising from (a) possible claims against a company's resources due to future performance under contract terms, and (b) possible losses or likely gains from uncertainties that will ultimately be resolved when one or more future events that are deemed likely to occur do occur or fail to occur.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.25)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03.(a),19)<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03.17)<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 450<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=82911808&amp;loc=d3e14326-108349<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommitmentsAndContingencies</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Aggregate par or stated value of issued nonredeemable common stock (or common stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable common shares, par value and other disclosure concepts are in another section within stockholders' equity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ContractWithCustomerLiabilityCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable, classified as current.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=82913815&amp;loc=SL49130532-203044<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=82913815&amp;loc=SL49130531-203044<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130549-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ContractWithCustomerLiabilityCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConvertibleDebtCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of the carrying value of long-term convertible debt as of the balance sheet date that is scheduled to be repaid within one year or in the normal operating cycle if longer. Convertible debt is a financial instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConvertibleDebtCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConvertibleDebtNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying amount of long-term convertible debt as of the balance sheet date, net of the amount due in the next twelve months or greater than the normal operating cycle, if longer. The debt is convertible into another form of financial instrument, typically the entity's common stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConvertibleDebtNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The carrying amount of the equity component of convertible debt which may be settled in cash upon conversion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031897-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredIncomeTaxAssetsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, with jurisdictional netting.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredIncomeTaxAssetsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeAssetsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value, after the effects of master netting arrangements, of a financial asset or other contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 20<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=51824906&amp;loc=SL20225862-175312<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeAssetsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeLiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value, after the effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 20<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=51824906&amp;loc=SL20225862-175312<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeLiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquityMethodInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>This item represents the carrying amount on the entity's balance sheet of its investment in common stock of an equity method investee. This is not an indicator of the fair value of the investment, rather it is the initial cost adjusted for the entity's share of earnings and losses of the investee, adjusted for any distributions (dividends) and other than temporary impairment (OTTI) losses recognized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 323<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109237563&amp;loc=d3e33749-111570<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 25<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8813-108599<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.12)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquityMethodInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquitySecuritiesFvNi">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -URI http://asc.fasb.org/extlink&amp;oid=99377092&amp;loc=SL75136599-209740<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquitySecuritiesFvNi</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Goodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=77989000&amp;loc=SL49117168-202975<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=99380562&amp;loc=d3e13770-109266<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Goodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IntangibleAssetsNetExcludingGoodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph ((a)(1),(b))<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6388964&amp;loc=d3e16212-109274<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IntangibleAssetsNetExcludingGoodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InventoryNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after valuation and LIFO reserves of inventory expected to be sold, or consumed within one year or operating cycle, if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 35<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=68049868&amp;loc=d3e3927-108312<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.6(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InventoryNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Liabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Sum of the carrying amounts as of the balance sheet date of all liabilities that are recognized. Liabilities are probable future sacrifices of economic benefits arising from present obligations of an entity to transfer assets or provide services to other entities in the future.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.19-26)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Liabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LiabilitiesAndStockholdersEquity">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities and equity items, including the portion of equity attributable to noncontrolling interests, if any.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(25))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(32))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LiabilitiesAndStockholdersEquity</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Total obligations incurred as part of normal operations that are expected to be paid during the following twelve months or within one business cycle, if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.21)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LiabilitiesCurrentAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LiabilitiesCurrentAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NotesAndLoansReceivableGrossCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>An amount representing an agreement for an unconditional promise by the maker to pay the Entity (holder) a definite sum of money at a future date(s) within one year of the balance sheet date or the normal operating cycle, whichever is longer. Such amount may include accrued interest receivable in accordance with the terms of the debt. The debt also may contain provisions including a discount or premium, payable on demand, secured, or unsecured, interest bearing or noninterest bearing, among a myriad of other features and characteristics. This amount does not include amounts related to receivables held-for-sale.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.3(a),(b))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 310<br> -SubTopic 10<br> -Section 45<br> -Paragraph 9<br> -URI http://asc.fasb.org/extlink&amp;oid=82891408&amp;loc=d3e4531-111522<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NotesAndLoansReceivableGrossCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherAssetsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current assets classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.8)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherAssetsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherAssetsNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of noncurrent assets classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.17)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherAssetsNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherLiabilitiesNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities classified as other, due after one year or the normal operating cycle, if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.24)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherLiabilitiesNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(14))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(8))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(13))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ReceivablesNetCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The total amount due to the entity within one year of the balance sheet date (or one operating cycle, if longer) from outside sources, including trade accounts receivable, notes and loans receivable, as well as any other types of receivables, net of allowances established for the purpose of reducing such receivables to an amount that approximates their net realizable value.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(5))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(3))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 946<br> -SubTopic 210<br> -Section S99<br> -Paragraph 3<br> -Subparagraph (SX 210.6-06(3))<br> -URI http://asc.fasb.org/extlink&amp;oid=6488278&amp;loc=d3e604059-122996<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ReceivablesNetCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RetainedEarningsAccumulatedDeficit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cumulative amount of the reporting entity's undistributed earnings or deficit.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(30)(a)(3))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(23)(a)(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RetainedEarningsAccumulatedDeficit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShortTermInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of investments including trading securities, available-for-sale securities, held-to-maturity securities, and short-term investments classified as other and current.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(6))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(5))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(1)(g))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShortTermInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockholdersEquity">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 310<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SAB Topic 4.E)<br> -URI http://asc.fasb.org/extlink&amp;oid=27010918&amp;loc=d3e74512-122707<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(31))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(30))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockholdersEquity</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockholdersEquityAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockholdersEquityAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>18
<FILENAME>R3.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817447312">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares<br></strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementOfFinancialPositionAbstract', window );"><strong>Statement of Financial Position [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockParOrStatedValuePerShare', window );">Common stock, par value (USD per share)</a></td>
<td class="nump">$ 0.001<span></span>
</td>
<td class="nump">$ 0.001<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockSharesAuthorized', window );">Common stock, shares authorized (shares)</a></td>
<td class="nump">60,000,000<span></span>
</td>
<td class="nump">33,333,333<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockSharesIssued', window );">Common stock, shares issued (shares)</a></td>
<td class="nump">20,765,533<span></span>
</td>
<td class="nump">21,148,665<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockSharesOutstanding', window );">Common stock, shares outstanding (shares)</a></td>
<td class="nump">20,765,533<span></span>
</td>
<td class="nump">21,148,665<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockParOrStatedValuePerShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Face amount or stated value per share of common stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockParOrStatedValuePerShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockSharesAuthorized">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The maximum number of common shares permitted to be issued by an entity's charter and bylaws.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockSharesAuthorized</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockSharesIssued">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockSharesIssued</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares of common stock outstanding. Common stock represent the ownership interest in a corporation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementOfFinancialPositionAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementOfFinancialPositionAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>19
<FILENAME>R4.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6899295664">
<tr>
<th class="tl" colspan="2" rowspan="2"><div style="width: 200px;"><strong>CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)<br> shares in Thousands, $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenuesAbstract', window );"><strong>Revenues:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">$ 251,453<span></span>
</td>
<td class="nump">$ 141,102<span></span>
</td>
<td class="nump">$ 108,973<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingCostsAndExpensesAbstract', window );"><strong>Operating costs and expenses:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CostOfGoodsAndServicesSold', window );">Cost of material sales</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">6,337<span></span>
</td>
<td class="nump">5,366<span></span>
</td>
<td class="nump">5,571<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CostOfGoodsAndServicesSoldAmortization', window );">Amortization of intangibles</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">15,792<span></span>
</td>
<td class="nump">12,120<span></span>
</td>
<td class="nump">10,643<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ResearchAndDevelopmentExpense', window );">Research and development</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">27,863<span></span>
</td>
<td class="nump">26,887<span></span>
</td>
<td class="nump">21,221<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_GeneralAndAdministrativeExpense', window );">General and administrative</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">37,734<span></span>
</td>
<td class="nump">28,653<span></span>
</td>
<td class="nump">27,653<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingCostsAndExpenses', window );">Total operating costs and expenses</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">87,726<span></span>
</td>
<td class="nump">73,026<span></span>
</td>
<td class="nump">65,088<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingIncomeLoss', window );">Income from operations</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">163,727<span></span>
</td>
<td class="nump">68,076<span></span>
</td>
<td class="nump">43,885<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherNonoperatingIncomeExpenseAbstract', window );"><strong>Other income (expense):</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquitySecuritiesFvNiGainLoss', window );">Gain (loss) from Viking</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">50,187<span></span>
</td>
<td class="num">(2,048)<span></span>
</td>
<td class="num">(23,132)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentIncomeNonoperating', window );">Interest income</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">13,999<span></span>
</td>
<td class="nump">2,060<span></span>
</td>
<td class="nump">664<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InterestExpense', window );">Interest expense</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="num">(48,276)<span></span>
</td>
<td class="num">(13,460)<span></span>
</td>
<td class="num">(12,842)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherNonoperatingIncomeExpense', window );">Other income (expense), net</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="num">(6,307)<span></span>
</td>
<td class="nump">2,603<span></span>
</td>
<td class="num">(615)<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NonoperatingIncomeExpense', window );">Total other income (expense), net</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">9,603<span></span>
</td>
<td class="num">(10,845)<span></span>
</td>
<td class="num">(35,925)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments', window );">Income before income tax expense</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">173,330<span></span>
</td>
<td class="nump">57,231<span></span>
</td>
<td class="nump">7,960<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxExpenseBenefit', window );">Income tax expense</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="num">(30,009)<span></span>
</td>
<td class="num">(44,675)<span></span>
</td>
<td class="num">(10,327)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest', window );">Income (loss) from operations</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">143,321<span></span>
</td>
<td class="nump">12,556<span></span>
</td>
<td class="num">(2,367)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract', window );"><strong>Discontinued operations:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax', window );">Gain on sale of Oncology Product Line before income taxes</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">1,139<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation', window );">Income tax expense on discontinued operations</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="num">(408)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax', window );">Income from discontinued operations</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">731<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">$ 143,321<span></span>
</td>
<td class="nump">$ 12,556<span></span>
</td>
<td class="num">$ (1,636)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareBasicAbstract', window );"><strong>Basic per share amounts:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare', window );">Income (loss) from continuing operations (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">$ 6.77<span></span>
</td>
<td class="nump">$ 0.60<span></span>
</td>
<td class="num">$ (0.11)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare', window );">Income from discontinued operations (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0.04<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareBasic', window );">Net income (loss) - Basic (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">6.77<span></span>
</td>
<td class="nump">0.60<span></span>
</td>
<td class="num">(0.08)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareDilutedAbstract', window );"><strong>Diluted per share amounts:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare', window );">Income (loss) from continuing operations (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">5.96<span></span>
</td>
<td class="nump">0.53<span></span>
</td>
<td class="num">(0.11)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare', window );">Income from discontinued operations (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0.04<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareDiluted', window );">Net (loss) income - Diluted (USD per share)</a></td>
<td class="th" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">$ 5.96<span></span>
</td>
<td class="nump">$ 0.53<span></span>
</td>
<td class="num">$ (0.08)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract', window );"><strong>Weighted average common shares outstanding:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic', window );">Basic (shares)</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">21,160<span></span>
</td>
<td class="nump">21,032<span></span>
</td>
<td class="nump">20,831<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding', window );">Diluted (shares)</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">24,067<span></span>
</td>
<td class="nump">23,481<span></span>
</td>
<td class="nump">20,831<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=us-gaap_RoyaltyMember', window );">Royalties</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenuesAbstract', window );"><strong>Revenues:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">$ 128,556<span></span>
</td>
<td class="nump">$ 88,685<span></span>
</td>
<td class="nump">$ 59,423<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember', window );">Material sales</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenuesAbstract', window );"><strong>Revenues:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">29,123<span></span>
</td>
<td class="nump">22,070<span></span>
</td>
<td class="nump">22,502<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember', window );">License fees, milestones and other revenues</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenuesAbstract', window );"><strong>Revenues:</strong></a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="th" style="border-bottom: 0px;"><sup></sup></td>
<td class="nump">$ 93,774<span></span>
</td>
<td class="nump">$ 30,347<span></span>
</td>
<td class="nump">$ 27,048<span></span>
</td>
</tr>
<tr><td colspan="5"></td></tr>
<tr><td colspan="5"><table class="outerFootnotes" width="100%"><tr class="outerFootnote">
<td style="vertical-align: top; width: 12pt;" valign="top">[1]</td>
<td style="vertical-align: top;" valign="top">The sum of net income per share amounts may not equal the total due to rounding</td>
</tr></table></td></tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CostOfGoodsAndServicesSold">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.2(a),(d))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CostOfGoodsAndServicesSold</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CostOfGoodsAndServicesSoldAmortization">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(b)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CostOfGoodsAndServicesSoldAmortization</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before tax of gain (loss) not previously recognized resulting from the disposal of a discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=d3e1361-107760<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=d3e957-107759<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3B<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=SL51721525-107759<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of gain (loss) not previously recognized resulting from the disposal of a discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=d3e957-107759<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=d3e1361-107760<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3B<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=SL51721525-107759<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5C<br> -Subparagraph (b)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=SL51721675-107760<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of tax expense (benefit) on gain (loss) not previously recognized resulting from the disposal of a discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3B<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=SL51721525-107759<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5C<br> -Subparagraph (b)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=SL51721675-107760<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 10<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32672-109319<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=d3e1361-107760<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareBasic">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 3: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 55<br> -Paragraph 52<br> -URI http://asc.fasb.org/extlink&amp;oid=109256448&amp;loc=d3e4984-109258<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 250<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=109234566&amp;loc=d3e22694-107794<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareBasic</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareBasicAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareBasicAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareDiluted">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 55<br> -Paragraph 52<br> -URI http://asc.fasb.org/extlink&amp;oid=109256448&amp;loc=d3e4984-109258<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 250<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=109234566&amp;loc=d3e22694-107794<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareDiluted</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareDilutedAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareDilutedAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquitySecuritiesFvNiGainLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of unrealized and realized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 321<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=84241550&amp;loc=SL75117546-209714<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquitySecuritiesFvNiGainLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_GeneralAndAdministrativeExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.4)<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_GeneralAndAdministrativeExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of income (loss) from continuing operations before deduction of income tax expense (benefit) and income (loss) attributable to noncontrolling interest, and addition of income (loss) from equity method investments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(h)(1)(i))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of income (loss) from continuing operations including portion attributable to the noncontrolling interest.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 45<br> -Paragraph 19<br> -URI http://asc.fasb.org/extlink&amp;oid=108774443&amp;loc=SL4569616-111683<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromContinuingOperationsPerBasicShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) from continuing operations per each share of common stock or unit outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(11))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-03(13))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868656-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromContinuingOperationsPerBasicShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) derived from continuing operations during the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(11))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-03(13))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868656-224227<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Per basic share amount, after tax, of income (loss) from the day-to-day business activities of the discontinued operation and gain (loss) from the disposal of the discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1278-109256<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(12))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(14))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Per diluted share amount, after tax, of income (loss) from the day-to-day business activities of the discontinued operation and gain (loss) from the disposal of the discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section S99<br> -Paragraph 5<br> -Subparagraph (SAB Topic 5.E)<br> -URI http://asc.fasb.org/extlink&amp;oid=27015204&amp;loc=d3e355146-122828<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1278-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (h)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InterestExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the cost of borrowed funds accounted for as interest expense.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6450988&amp;loc=d3e26243-108391<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28555-108399<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (210.5-03(11))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04.9)<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InterestExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentIncomeNonoperating">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate amount of income from investments (for example, dividends) not considered a component of the entity's core operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentIncomeNonoperating</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(22))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(18))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NonoperatingIncomeExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate amount of income or expense from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NonoperatingIncomeExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingCostsAndExpenses">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Excludes Selling, General and Administrative Expense.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingCostsAndExpenses</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingCostsAndExpensesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingCostsAndExpensesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The net result for the period of deducting operating expenses from operating revenues.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherNonoperatingIncomeExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of income (expense) related to nonoperating activities, classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.9)<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherNonoperatingIncomeExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherNonoperatingIncomeExpenseAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherNonoperatingIncomeExpenseAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ResearchAndDevelopmentExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 985<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6501960&amp;loc=d3e128462-111756<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 730<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6420194&amp;loc=d3e21568-108373<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ResearchAndDevelopmentExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130543-203045<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130539-203045<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130545-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenuesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenuesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 16<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1505-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1448-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfSharesOutstandingBasic</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=us-gaap_RoyaltyMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=us-gaap_RoyaltyMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>20
<FILENAME>R5.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6815967072">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract', window );"><strong>Statement of Comprehensive Income [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="nump">$ 143,321<span></span>
</td>
<td class="nump">$ 12,556<span></span>
</td>
<td class="num">$ (1,636)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax', window );">Unrealized net gain on available-for-sale securities, net of tax</a></td>
<td class="nump">73<span></span>
</td>
<td class="nump">143<span></span>
</td>
<td class="nump">93<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax', window );">Foreign currency translation</a></td>
<td class="num">(921)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax', window );">Less:Reclassification of net realized gains included in net income (loss), net of tax</a></td>
<td class="nump">0<span></span>
</td>
<td class="num">(400)<span></span>
</td>
<td class="num">(2,253)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ComprehensiveIncomeNetOfTax', window );">Comprehensive income (loss)</a></td>
<td class="nump">$ 142,473<span></span>
</td>
<td class="nump">$ 12,299<span></span>
</td>
<td class="num">$ (3,796)<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ComprehensiveIncomeNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=d3e557-108580<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ComprehensiveIncomeNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(22))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(18))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax and reclassification adjustments, of appreciation (loss) in value of unsold available-for-sale securities. Excludes amounts related to other than temporary impairment (OTTI) loss.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10A<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669646-108580<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax and reclassification adjustments of gain (loss) on foreign currency translation adjustments, foreign currency transactions designated and effective as economic hedges of a net investment in a foreign entity and intra-entity foreign currency transactions that are of a long-term-investment nature.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669646-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 830<br> -SubTopic 30<br> -Section 45<br> -Paragraph 20<br> -Subparagraph (b,c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109240241&amp;loc=d3e32211-110900<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of reclassification adjustment from accumulated other comprehensive income for unrealized gain (loss) realized upon the sale of available-for-sale securities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=d3e689-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=d3e637-108580<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=82897076&amp;loc=d3e27357-111563<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 17A<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL34724391-108580<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>21
<FILENAME>R6.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6900681872">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Total</div></th>
<th class="th"><div>2019 Convertible Senior Notes</div></th>
<th class="th"><div>2023 Convertible Senior Notes</div></th>
<th class="th"><div>Common Stock</div></th>
<th class="th"><div>Additional paid-in capital</div></th>
<th class="th">
<div>Additional paid-in capital </div>
<div>2019 Convertible Senior Notes</div>
</th>
<th class="th">
<div>Additional paid-in capital </div>
<div>2023 Convertible Senior Notes</div>
</th>
<th class="th"><div>Accumulated other comprehensive income (loss)</div></th>
<th class="th"><div>Accumulated deficit</div></th>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharesOutstanding', window );">Balance at beginning of period (shares) at Dec. 31, 2015</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">19,949,012<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest', window );">Balance at beginning of period at Dec. 31, 2015</a></td>
<td class="nump">$ 237,282<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 20<span></span>
</td>
<td class="nump">$ 661,850<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 4,903<span></span>
</td>
<td class="num">$ (429,491)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward', window );"><strong>Increase (Decrease) in Stockholders' Equity [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans', window );">Issuance of common stock under employee stock compensation plans, net (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">210,626<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation', window );">Issuance of common stock under employee stock compensation plans, net</a></td>
<td class="nump">5,416<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5,416<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodSharesAcquisitions', window );">Shares issued in OMT acquisition (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">790,163<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions', window );">Shares issued in OMT acquisition</a></td>
<td class="nump">77,331<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 1<span></span>
</td>
<td class="nump">77,330<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt', window );">Reclassification of equity component of currently redeemable convertible notes</a></td>
<td class="nump">10,065<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10,065<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue', window );">Stock-based compensation</a></td>
<td class="nump">$ 18,893<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">18,893<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodShares', window );">Repurchase of common stock (shares)</a></td>
<td class="num">(40,500)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(40,500)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodValue', window );">Repurchase of common stock</a></td>
<td class="num">$ (3,901)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(3,901)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossNetOfTax', window );">Other comprehensive income (loss)</a></td>
<td class="num">(2,160)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(2,160)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="num">(1,636)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(1,636)<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharesOutstanding', window );">Balance at end of period (shares) at Dec. 31, 2016</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20,909,301<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest', window );">Balance at end of period at Dec. 31, 2016</a></td>
<td class="nump">341,290<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 21<span></span>
</td>
<td class="nump">769,653<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,743<span></span>
</td>
<td class="num">(431,127)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward', window );"><strong>Increase (Decrease) in Stockholders' Equity [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans', window );">Issuance of common stock under employee stock compensation plans, net (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">253,364<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation', window );">Issuance of common stock under employee stock compensation plans, net</a></td>
<td class="num">(5,558)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(5,558)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions', window );">Shares issued in OMT acquisition</a></td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt', window );">Reclassification of equity component of currently redeemable convertible notes</a></td>
<td class="nump">10,704<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10,704<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue', window );">Stock-based compensation</a></td>
<td class="nump">$ 24,916<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">24,916<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodShares', window );">Repurchase of common stock (shares)</a></td>
<td class="num">(14,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(14,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodValue', window );">Repurchase of common stock</a></td>
<td class="num">$ (1,966)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(1,966)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossNetOfTax', window );">Other comprehensive income (loss)</a></td>
<td class="num">(257)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(257)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="nump">12,556<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">12,556<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharesOutstanding', window );">Balance at end of period (shares) at Dec. 31, 2017</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">21,148,665<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest', window );">Balance at end of period at Dec. 31, 2017</a></td>
<td class="nump">399,788<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 21<span></span>
</td>
<td class="nump">798,205<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,486<span></span>
</td>
<td class="num">(400,924)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward', window );"><strong>Increase (Decrease) in Stockholders' Equity [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans', window );">Issuance of common stock under employee stock compensation plans, net (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">399,116<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation', window );">Issuance of common stock under employee stock compensation plans, net</a></td>
<td class="nump">16,417<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">16,417<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions', window );">Shares issued in OMT acquisition</a></td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt', window );">Reclassification of equity component of currently redeemable convertible notes</a></td>
<td class="nump">18,859<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">18,859<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue', window );">Stock-based compensation</a></td>
<td class="nump">$ 20,846<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20,846<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodShares', window );">Repurchase of common stock (shares)</a></td>
<td class="num">(782,248)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(782,248)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodValue', window );">Repurchase of common stock</a></td>
<td class="num">$ (127,481)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(127,481)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherComprehensiveIncomeLossNetOfTax', window );">Other comprehensive income (loss)</a></td>
<td class="nump">73<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">73<span></span>
</td>
<td class="text"> <span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature', window );">Convertible bond hedge and warrant transactions, net of tax</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,559)<span></span>
</td>
<td class="num">$ (1,807)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,559)<span></span>
</td>
<td class="num">$ (1,807)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes', window );">Loss on settlement of Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,187<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,187<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased', window );">Warrant repurchase</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(30,472)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(30,472)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants', window );">Loss on repurchase of warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,792<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,792<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions', window );">Tax effect for Notes transactions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,680)<span></span>
</td>
<td class="num">(3,181)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,680)<span></span>
</td>
<td class="num">(3,181)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued', window );">Warrant derivative</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 97,805<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 97,805<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment', window );">Foreign currency translation adjustment</a></td>
<td class="num">(921)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(921)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther', window );">Other tax reclassifications</a></td>
<td class="nump">346<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">183<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">163<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="nump">143,321<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">143,321<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharesOutstanding', window );">Balance at end of period (shares) at Dec. 31, 2018</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20,765,533<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rc">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest', window );">Balance at end of period at Dec. 31, 2018</a></td>
<td class="nump">$ 560,914<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 21<span></span>
</td>
<td class="nump">$ 791,114<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,024)<span></span>
</td>
<td class="num">$ (229,197)<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, Foreign Currency Translation Adjustment</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, (Gain) Loss on Repurchase of Warrants</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, Loss on Settlement of Convertible Senior Notes</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, Tax Effect of Convertible Senior Notes Transactions</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, Warrants Repurchased</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in additional paid in capital (APIC) resulting from recognition of deferred taxes for convertible debt with a beneficial conversion feature.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 55<br> -Paragraph 51<br> -URI http://asc.fasb.org/extlink&amp;oid=109238393&amp;loc=d3e34017-109320<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustment to additional paid in capital resulting from the recognition of convertible debt instruments as two separate components - a debt component and an equity component. This bifurcation may result in a basis difference associated with the liability component that represents a temporary difference for purposes of applying accounting for income taxes. The initial recognition of deferred taxes for the tax effect of that temporary difference is as an adjustment to additional paid in capital.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 25<br> -Paragraph 22<br> -URI http://asc.fasb.org/extlink&amp;oid=51819886&amp;loc=SL6014347-161799<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalOther">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of other increase (decrease) in additional paid in capital (APIC).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalOther</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase to additional paid-in capital (APIC) from recognition of equity-based compensation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 20<br> -Section 55<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=109196918&amp;loc=d3e11149-113907<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5047-113901<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 20<br> -Section 55<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=109196918&amp;loc=d3e11178-113907<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 35<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=79507207&amp;loc=d3e4534-113899<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase in additional paid in capital (APIC) resulting from the issuance of warrants. Includes allocation of proceeds of debt securities issued with detachable stock purchase warrants.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 25<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109126253&amp;loc=d3e4724-112606<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInStockholdersEquityRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(22))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(18))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherComprehensiveIncomeLossNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax and reclassification adjustments of other comprehensive income (loss).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 55<br> -Paragraph 15<br> -URI http://asc.fasb.org/extlink&amp;oid=109228884&amp;loc=d3e1436-108581<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherComprehensiveIncomeLossNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares issued which are neither cancelled nor held in the treasury.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodSharesAcquisitions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares of stock issued during the period pursuant to acquisitions.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodSharesAcquisitions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares issued during the period as a result of an employee stock purchase plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of stock issued pursuant to acquisitions during the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.29-31)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodValueAcquisitions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of stock (or other type of equity) issued during the period as a result of any equity-based compensation plan other than an employee stock ownership plan (ESOP), net of stock value of such awards forfeited. Stock issued could result from the issuance of restricted stock, the exercise of stock options, stock issued under employee stock purchase plans, and/or other employee benefit plans.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5047-113901<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (d)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchasedDuringPeriodShares">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares that have been repurchased during the period and have not been retired and are not held in treasury. Some state laws may govern the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchasedDuringPeriodShares</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchasedDuringPeriodValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Equity impact of the value of stock that has been repurchased during the period and has not been retired and is not held in treasury. Some state laws may mandate the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchasedDuringPeriodValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of stockholders' equity (deficit), net of receivables from officers, directors, owners, and affiliates of the entity, attributable to both the parent and noncontrolling interests. Amount excludes temporary equity. Alternate caption for the concept is permanent equity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 45<br> -Paragraph 16<br> -URI http://asc.fasb.org/extlink&amp;oid=108774443&amp;loc=SL4568740-111683<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 55<br> -Paragraph 4I<br> -URI http://asc.fasb.org/extlink&amp;oid=84234705&amp;loc=SL4590271-111686<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -URI http://asc.fasb.org/extlink&amp;oid=108774443&amp;loc=SL4568447-111683<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>22
<FILENAME>R7.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6899250784">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract', window );"><strong>Operating activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProfitLoss', window );">Net income (loss)</a></td>
<td class="nump">$ 143,321<span></span>
</td>
<td class="nump">$ 12,556<span></span>
</td>
<td class="num">$ (1,636)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax', window );">Less: gain from discontinued operations</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">731<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest', window );">Income (loss) from continuing operations</a></td>
<td class="nump">143,321<span></span>
</td>
<td class="nump">12,556<span></span>
</td>
<td class="num">(2,367)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract', window );"><strong>Adjustments to reconcile net income to net cash provided by operating activities:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights', window );">Change in estimated fair value of contingent liabilities</a></td>
<td class="nump">3,448<span></span>
</td>
<td class="nump">2,580<span></span>
</td>
<td class="nump">3,334<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RealizedInvestmentGainsLosses', window );">Realized gain on sale of short-term investment</a></td>
<td class="num">(2,611)<span></span>
</td>
<td class="num">(831)<span></span>
</td>
<td class="num">(2,352)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DepreciationDepletionAndAmortization', window );">Depreciation and amortization</a></td>
<td class="nump">14,718<span></span>
</td>
<td class="nump">11,714<span></span>
</td>
<td class="nump">11,290<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeLossFromEquityMethodInvestments', window );">Loss on equity investment in Viking</a></td>
<td class="num">(42,346)<span></span>
</td>
<td class="nump">2,048<span></span>
</td>
<td class="nump">23,132<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant', window );">Change in fair value of the convertible debt receivable from Viking and warrants</a></td>
<td class="num">(5,411)<span></span>
</td>
<td class="num">(4,032)<span></span>
</td>
<td class="num">(462)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments', window );">Amortization of premium (discount) on investments, net</a></td>
<td class="num">(5,452)<span></span>
</td>
<td class="num">(81)<span></span>
</td>
<td class="nump">348<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AmortizationOfFinancingCostsAndDiscounts', window );">Amortization of debt discount and issuance fees</a></td>
<td class="nump">43,954<span></span>
</td>
<td class="nump">11,619<span></span>
</td>
<td class="nump">10,925<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensation', window );">Stock-based compensation</a></td>
<td class="nump">20,846<span></span>
</td>
<td class="nump">24,915<span></span>
</td>
<td class="nump">18,893<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes', window );">Deferred income taxes</a></td>
<td class="nump">29,739<span></span>
</td>
<td class="nump">44,518<span></span>
</td>
<td class="nump">10,697<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement', window );">Royalties recorded in retained earnings upon adoption of ASC 606</a></td>
<td class="nump">32,707<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue', window );">Change in derivative asset and liability fair value</a></td>
<td class="nump">2,931<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract', window );"><strong>Changes in operating assets and liabilities, net of acquisition:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInAccountsReceivable', window );">Accounts receivable, net</a></td>
<td class="num">(29,544)<span></span>
</td>
<td class="num">(8,358)<span></span>
</td>
<td class="num">(8,525)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInInventories', window );">Inventory</a></td>
<td class="num">(2,559)<span></span>
</td>
<td class="num">(843)<span></span>
</td>
<td class="num">(244)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets', window );">Other current assets</a></td>
<td class="num">(868)<span></span>
</td>
<td class="nump">402<span></span>
</td>
<td class="nump">526<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets', window );">Other long term assets</a></td>
<td class="nump">728<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">183<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities', window );">Accounts payable and accrued liabilities</a></td>
<td class="num">(4,542)<span></span>
</td>
<td class="num">(1,713)<span></span>
</td>
<td class="num">(2,369)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncreaseDecreaseInContingentLiabilities', window );">Contingent liabilities</a></td>
<td class="num">(3,842)<span></span>
</td>
<td class="num">(4,998)<span></span>
</td>
<td class="num">(2,268)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInContractWithCustomerLiability', window );">Deferred revenue</a></td>
<td class="num">(1,158)<span></span>
</td>
<td class="num">(926)<span></span>
</td>
<td class="num">(8)<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInOperatingActivities', window );">Net cash provided by operating activities</a></td>
<td class="nump">194,059<span></span>
</td>
<td class="nump">88,570<span></span>
</td>
<td class="nump">60,733<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract', window );"><strong>Investing activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PurchaseforCommercialLicenseRights', window );">Purchase of commercial license rights</a></td>
<td class="num">(10,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="num">(17,695)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired', window );">Cash paid for acquisition, net of cash acquired</a></td>
<td class="num">(5,856)<span></span>
</td>
<td class="num">(26,653)<span></span>
</td>
<td class="num">(92,502)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity', window );">Payments to CVR holders and other contingency payments</a></td>
<td class="num">(1,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment', window );">Purchases of property and equipment</a></td>
<td class="num">(887)<span></span>
</td>
<td class="num">(2,156)<span></span>
</td>
<td class="num">(1,850)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireShortTermInvestments', window );">Purchases of short-term investments</a></td>
<td class="num">(1,434,255)<span></span>
</td>
<td class="num">(254,258)<span></span>
</td>
<td class="num">(164,438)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromSaleOfShortTermInvestments', window );">Proceeds from sale of short-term investments</a></td>
<td class="nump">131,942<span></span>
</td>
<td class="nump">86,985<span></span>
</td>
<td class="nump">24,596<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments', window );">Proceeds from maturity of short-term investments</a></td>
<td class="nump">892,873<span></span>
</td>
<td class="nump">109,649<span></span>
</td>
<td class="nump">118,874<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromLicenseFeesReceived', window );">Proceeds from commercial license rights</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">7,054<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromCollectionOfNotesReceivable', window );">Proceeds received from repayment of Viking note receivable</a></td>
<td class="nump">3,914<span></span>
</td>
<td class="nump">200<span></span>
</td>
<td class="nump">300<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivities', window );">Net cash used in investing activities</a></td>
<td class="num">(423,269)<span></span>
</td>
<td class="num">(79,179)<span></span>
</td>
<td class="num">(134,415)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract', window );"><strong>Financing activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RepaymentsOfLongTermDebt', window );">Repayments of debt</a></td>
<td class="num">(217,674)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromNotesPayable', window );">Gross proceeds from issuance of 2023 Convertible Senior Notes</a></td>
<td class="nump">750,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsOfDebtIssuanceCosts', window );">Payment of debt issuance costs</a></td>
<td class="num">(16,900)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromIssuanceOfWarrants', window );">Proceeds from issuance of warrants</a></td>
<td class="nump">90,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PurchaseOfConvertibleBondHedge', window );">Purchase of convertible bond hedge</a></td>
<td class="num">(140,250)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromHedgeFinancingActivities', window );">Proceeds from bond hedge</a></td>
<td class="nump">439,559<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsForHedgeFinancingActivities', window );">Payments to convert holders for bond conversion</a></td>
<td class="num">(439,581)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromStockOptionsExercised', window );">Net proceeds from stock option exercises and ESPP</a></td>
<td class="nump">20,183<span></span>
</td>
<td class="nump">4,517<span></span>
</td>
<td class="nump">6,415<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation', window );">Taxes paid related to net share settlement of equity awards</a></td>
<td class="num">(3,765)<span></span>
</td>
<td class="num">(10,074)<span></span>
</td>
<td class="num">(999)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsForRepurchaseOfCommonStock', window );">Share repurchases</a></td>
<td class="num">(122,868)<span></span>
</td>
<td class="num">(1,966)<span></span>
</td>
<td class="num">(3,901)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsForRepurchaseOfWarrants', window );">Repurchase of warrants</a></td>
<td class="num">(30,094)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity', window );">Payments to CVR holders</a></td>
<td class="num">(25)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="num">(6,509)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInFinancingActivities', window );">Net cash (used in) provided by financing activities</a></td>
<td class="nump">328,585<span></span>
</td>
<td class="num">(7,523)<span></span>
</td>
<td class="num">(4,994)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents', window );">Effect of exchange rate changes on cash</a></td>
<td class="num">(215)<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect', window );">Net increase (decrease) in cash and cash equivalents</a></td>
<td class="nump">99,375<span></span>
</td>
<td class="nump">1,868<span></span>
</td>
<td class="num">(78,676)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents', window );">Cash, cash equivalents, and restricted cash at end of year</a></td>
<td class="nump">119,780<span></span>
</td>
<td class="nump">20,620<span></span>
</td>
<td class="nump">18,752<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents', window );">Cash, cash equivalents, and restricted cash at beginning of year</a></td>
<td class="nump">20,620<span></span>
</td>
<td class="nump">18,752<span></span>
</td>
<td class="nump">97,428<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SupplementalCashFlowInformationAbstract', window );"><strong>Supplemental disclosure of cash flow information</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InterestPaidNet', window );">Interest paid</a></td>
<td class="nump">1,513<span></span>
</td>
<td class="nump">1,838<span></span>
</td>
<td class="nump">1,838<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxesPaid', window );">Taxes paid</a></td>
<td class="nump">341<span></span>
</td>
<td class="nump">157<span></span>
</td>
<td class="nump">38<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract', window );"><strong>Supplemental schedule of non-cash investing and financing activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions', window );">Stock issued for acquisition, net of issuance cost</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="num">(77,331)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_EquityReceivedinRepaymentofNoteReceivable', window );">Stock and warrant received for repayment of Viking notes receivable</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">1,200<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AccruedInventoryPurchases', window );">Accrued inventory purchases</a></td>
<td class="nump">2,059<span></span>
</td>
<td class="nump">1,007<span></span>
</td>
<td class="nump">646<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrealizedGainLossOnInvestments', window );">Unrealized gain on AFS investments</a></td>
<td class="nump">48<span></span>
</td>
<td class="nump">144<span></span>
</td>
<td class="num">(1,109)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_VikingTherapeuticsInc.Member', window );">Viking Therapeutics, Inc.</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract', window );"><strong>Investing activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireEquityMethodInvestments', window );">Common stock and warrants in equity method investments</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="num">(700)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_PurchaseofCommonStockMember', window );">Purchase of Common Stock</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract', window );"><strong>Investing activities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireEquityMethodInvestments', window );">Common stock and warrants in equity method investments</a></td>
<td class="nump">$ 0<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="num">$ (1,000)<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AccruedInventoryPurchases">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accrued Inventory Purchases</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AccruedInventoryPurchases</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ChangeInDerivativeAssetAndLiabilityFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Change in Derivative Asset and Liability Fair Value</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ChangeInDerivativeAssetAndLiabilityFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_EquityReceivedinRepaymentofNoteReceivable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Equity Received in Repayment of Note Receivable</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_EquityReceivedinRepaymentofNoteReceivable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncreaseDecreaseInContingentLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Increase (Decrease) in Contingent Liabilities</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncreaseDecreaseInContingentLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Increase (Decrease) in Fair Value of Convertible Debt Receivable and Warrant</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Non-cash change in estimated fair value of contingent value rights.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Payments to Contingent Value Right Holders and Other Contingency Payments, Investing Activity</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PaymentsToContingentValueRightHoldersFinancingActivity">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Payments to Contingent Value Right Holders, Financing Activity</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PaymentsToContingentValueRightHoldersFinancingActivity</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PurchaseOfConvertibleBondHedge">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Purchase of Convertible Bond Hedge</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PurchaseOfConvertibleBondHedge</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PurchaseforCommercialLicenseRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Purchase for Commercial License Rights</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PurchaseforCommercialLicenseRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Royalties Recorded upon Adoption of New Accounting Pronouncement</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AmortizationOfFinancingCostsAndDiscounts">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense attributable to debt discount (premium) and debt issuance costs.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28555-108399<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AmortizationOfFinancingCostsAndDiscounts</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage. Excludes amount for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3044-108585<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=SL98516268-108586<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; excluding effect from exchange rate change. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 830<br> -SubTopic 230<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=98513438&amp;loc=d3e33268-110906<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DepreciationDepletionAndAmortization">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DepreciationDepletionAndAmortization</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of income (loss) from operations classified as a discontinued operation. Excludes gain (loss) on disposal and provision for gain (loss) until disposal.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5C<br> -Subparagraph (b)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=SL51721675-107760<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=d3e957-107759<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3A<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=SL51721523-107759<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) from effect of exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies. Excludes amounts for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 830<br> -SubTopic 230<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=98513438&amp;loc=d3e33268-110906<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of income (loss) from continuing operations including portion attributable to the noncontrolling interest.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 45<br> -Paragraph 19<br> -URI http://asc.fasb.org/extlink&amp;oid=108774443&amp;loc=SL4569616-111683<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeLossFromEquityMethodInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>This item represents the entity's proportionate share for the period of the net income (loss) of its investee (such as unconsolidated subsidiaries and joint ventures) to which the equity method of accounting is applied. This item includes income or expense related to stock-based compensation based on the investor's grant of stock to employees of an equity method investee.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(12))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(10))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(13)(f))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (g)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 323<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109237563&amp;loc=d3e33749-111570<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeLossFromEquityMethodInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxesPaid">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of cash paid during the current period to foreign, federal, state, and local authorities as taxes on income.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4297-108586<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -Subparagraph (f)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxesPaid</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the reporting period in the amounts payable to vendors for goods and services received and the amount of obligations and expenses incurred but not paid.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInAccountsReceivable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the reporting period in amount due within one year (or one business cycle) from customers for the credit sale of goods and services.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInAccountsReceivable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInContractWithCustomerLiability">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in obligation to transfer good or service to customer for which consideration has been received or is receivable.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInContractWithCustomerLiability</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInDeferredIncomeTaxes">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the reporting period in the account that represents the temporary difference that results from Income or Loss that is recognized for accounting purposes but not for tax purposes and vice versa.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInDeferredIncomeTaxes</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInInventories">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the reporting period in the aggregate value of all inventory held by the reporting entity, associated with underlying transactions that are classified as operating activities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInInventories</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInOperatingCapitalAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in noncurrent assets classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInOtherNoncurrentAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in prepaid expenses, and assets classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InterestPaidNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash paid for interest, excluding capitalized interest, classified as operating activity. Includes, but is not limited to, payment to settle zero-coupon bond for accreted interest of debt discount and debt instrument with insignificant coupon interest rate in relation to effective interest rate of borrowing attributable to accreted interest of debt discount.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4297-108586<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 17<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3367-108585<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InterestPaidNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInFinancingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from financing activities, including discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInFinancingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInInvestingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from investing activities, including discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInInvestingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInOperatingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInOperatingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsForHedgeFinancingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow for a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 27<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3581-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsForHedgeFinancingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsForRepurchaseOfCommonStock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow to reacquire common stock during the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsForRepurchaseOfCommonStock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsForRepurchaseOfWarrants">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate amount paid by the entity to reacquire the right to purchase equity shares at a predetermined price, usually issued together with corporate debt.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsForRepurchaseOfWarrants</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsOfDebtIssuanceCosts">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsOfDebtIssuanceCosts</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash outflow to satisfy an employee's income tax withholding obligation as part of a net-share settlement of a share-based award.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 25<br> -Paragraph 19A<br> -URI http://asc.fasb.org/extlink&amp;oid=107668666&amp;loc=SL79513924-113897<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow associated with the acquisition of a business, net of the cash acquired from the purchase.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquireEquityMethodInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquireEquityMethodInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquirePropertyPlantAndEquipment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquireShortTermInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquireShortTermInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromCollectionOfNotesReceivable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow associated with principal collections from a borrowing supported by a written promise to pay an obligation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 12<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3179-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromCollectionOfNotesReceivable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromHedgeFinancingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 27<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3581-108585<br><br>Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromHedgeFinancingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromIssuanceOfWarrants">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromIssuanceOfWarrants</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromLicenseFeesReceived">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash received from licensees for license fees during the current period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromLicenseFeesReceived</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from maturities, prepayments, calls and collections of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3179-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromNotesPayable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from a borrowing supported by a written promise to pay an obligation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromNotesPayable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromSaleOfShortTermInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3179-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromSaleOfShortTermInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromStockOptionsExercised">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=SL79508275-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromStockOptionsExercised</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProfitLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1A<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109239629&amp;loc=SL4573702-111684<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1A<br> -Subparagraph (c)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109239629&amp;loc=SL4573702-111684<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 6: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 55<br> -Paragraph 4J<br> -URI http://asc.fasb.org/extlink&amp;oid=84234705&amp;loc=SL4591551-111686<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3000-108585<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 45<br> -Paragraph 19<br> -URI http://asc.fasb.org/extlink&amp;oid=108774443&amp;loc=SL4569616-111683<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 32<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8933-108599<br><br>Reference 10: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 55<br> -Paragraph 4K<br> -URI http://asc.fasb.org/extlink&amp;oid=84234705&amp;loc=SL4591552-111686<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProfitLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RealizedInvestmentGainsLosses">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The net realized gains or losses on investments during the period, not including gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04.3(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RealizedInvestmentGainsLosses</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RepaymentsOfLongTermDebt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RepaymentsOfLongTermDebt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodValueAcquisitions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of stock issued pursuant to acquisitions during the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.29-31)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodValueAcquisitions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SupplementalCashFlowInformationAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SupplementalCashFlowInformationAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrealizedGainLossOnInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrealizedGainLossOnInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_VikingTherapeuticsInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_VikingTherapeuticsInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_PurchaseofCommonStockMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis=lgnd_PurchaseofCommonStockMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>23
<FILENAME>R8.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889563888">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract', window );"><strong>Organization, Consolidation and Presentation of Financial Statements [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock', window );">Basis of Presentation and Summary of Significant Accounting Policies</a></td>
<td class="text">Basis of Presentation and Summary of Significant Accounting Policies<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Business</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ligand is a biopharmaceutical company with a business model based on developing or acquiring assets which generate royalty, milestone or other passive revenue for the Company using a lean corporate cost structure. We operate in one business segment: development and licensing of biopharmaceutical assets.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Principles of Consolidation</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The accompanying consolidated financial statements include Ligand and its wholly-owned subsidiaries.  All significant intercompany accounts and transactions have been eliminated in consolidation.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Basis of Presentation</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our consolidated financial statements have been prepared in accordance with U.S. GAAP and include the accounts of our parent company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Reclassifications</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Certain reclassifications have been made to the previously issued statement of operations to conform with the current period presentation. See detail in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Accounting Standards Recently Adopted</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> subsection below for further information. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Use of Estimates</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preparation of consolidated financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes.  Actual results may differ from those estimates.</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Concentrations of Business Risk</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Financial instruments that potentially subject to significant concentrations of credit risk consist primarily of cash equivalents and investments. We invest&#160;excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A relatively small number of partners account for a significant percentage of our revenue. Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:52.344624%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner A</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">40&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">41&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner B</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">13&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner C</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; 10%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; 10%&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We obtain Captisol from two sites at a single supplier, Hovione.&#160;If this supplier were not able to supply the requested amounts of Captisol from each site, and if our safety stocks of material were depleted, we would be unable to continue to derive revenues from the sale of Captisol until we obtained material from an alternative source, which could take a considerable length of time.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Cash Equivalents &amp; Short Term Investments</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Cash equivalents consist of all investments with maturities of&#160;three months or less from the date of acquisition. Short-term investments primarily consist of investments in debt securities that have effective maturities greater than&#160;three&#160;months and less than twelve months from the date of acquisition. We classify our short-term investments as "available-for-sale". Such investments are carried at fair value, with unrealized gains and losses included in the statement of comprehensive income (loss).&#160;We determine the cost of investments based on the specific identification method.&#160;</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounts Receivable</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Trade accounts receivable are recorded at the net invoice value and are not interest bearing. We consider receivables past due based on the contractual payment terms which range from 30 to 90 days. We&#160;reserve specific receivables if collectability is no longer reasonably assured. We re-evaluate such reserves on a regular basis and adjust the reserves as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Inventory</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Inventory, which consists of finished goods, is stated at the lower of cost or market value. We&#160;determine cost using the first-in, first-out method. We analyze our inventory levels periodically and write down inventory to net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements. There were no write downs related to obsolete inventory recorded for the years ended December&#160;31, 2018,&#160;2017 and&#160;2016.  </span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and Equipment</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, which generally range from three to ten years, using the straight-line method. Amortization of leasehold improvements is recorded over the shorter of the lease term or estimated useful life of the related asset. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Business Combinations</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition method of accounting for business combinations requires us to use significant estimates and assumptions, including fair value estimates, as of the business combination date and to refine those estimates as necessary during the measurement period (defined as the period, not to exceed one year, in which we may adjust the provisional amounts recognized for a business combination).</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting, we recognize separately from goodwill the identifiable assets acquired, the liabilities assumed, including contingent consideration and all contractual contingencies, generally at the acquisition date fair value. Contingent purchase consideration to be settled in cash are remeasured to estimated fair value at each reporting period with the change in fair value recorded in other income (expense), net. Costs that we incur to complete the business combination such as investment banking, legal and other professional fees are not considered part of consideration and we charge them to general and administrative expense as they are incurred. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We measure goodwill as of the acquisition date as the excess of consideration transferred, which we also measure at fair value, over the net of the acquisition date amounts of the identifiable assets acquired and liabilities assumed. In addition, IPR&amp;D is capitalized and assessed for impairment annually.  IPR&amp;D is amortized upon product commercialization or upon out-licensing the underlying intellectual property where we have no active involvement in the licensee's development activities. IPR&amp;D is amortized over the estimated life of the commercial product or licensing arrangement.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Should the initial accounting for a business combination be incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date and we record those adjustments to our financial statements in the period of change, if any.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting for business combinations, if we identify changes to acquired deferred tax asset valuation allowances or liabilities related to uncertain tax positions during the measurement period and they relate to new information obtained about facts and circumstances that existed as of the acquisition date, those changes are considered a</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> measurement period adjustment and we record the offset to goodwill. We record all other changes to deferred tax asset valuation allowances and liabilities related to uncertain tax positions in current period income tax expense. </span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Contingent Liabilities</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of Crystal in October 2017, we may be required to pay up to an additional $10.5 million in purchase consideration upon achievement of certain commercial and development milestones to the Crystal shareholders. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of CyDex in January 2011, we recorded a contingent liability for amounts potentially due to holders of the CyDex CVRs and former license holders. The liability is periodically assessed based on events and circumstances related to the underlying milestones, royalties and material sales.  In connection with the acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs for each Metabasis share. The fair values of the CVRs are remeasured at each reporting date through the term of the related agreement. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Any change in fair value is recorded in our consolidated statement of operations. For additional information, see &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (4), Fair Value Measurement and Note (7), Balance Sheet Account Details</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">.&#8221; &#160;&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill, Intangible Assets and Other Long-Lived Assets</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if an event occurs indicating the potential for impairment. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than the carrying amount, including goodwill. We operate in one reporting unit. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair value of our reporting unit is less than the carrying amount, then no additional assessment is deemed necessary. Otherwise, we proceed to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with the carrying value, including goodwill. If the carrying amount of the reporting unit exceeds the fair value, the second step of the goodwill impairment test is performed to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. We may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. We performed the annual assessment for goodwill impairment during the fourth quarter of 2018, noting no impairment. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our identifiable intangible assets are typically composed of&#160;acquired core technologies, licensed technologies, customer relationships and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets&#8217; respective estimated useful lives. We regularly perform reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows, and the pattern of utilization of a particular asset.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Commercial license rights</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights consist of the following (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"/><td style="width:71.893805%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.537463%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, </span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo &amp; CorMatrix</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,298&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,298&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less: accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,838)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,772)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total commercial license rights, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">31,460&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,526&#160;</span></td></tr></table></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights represent a portfolio of future milestone and royalty payment rights acquired from Selexis in April 2013 and April 2015, CorMatrix in May 2016, and Pavella in December 2018. Individual commercial license rights acquired are accounted for as financial assets further discussed below. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In December 2018, we entered into a development funding and royalties agreement with Palvella.&#160;Pursuant to the agreement, we will receive up to $8.0 million of milestone payments upon the achievement by&#160;Palvella of certain regulatory milestones for PTX-022, a&#160;product candidate being developed to treat pachyonychia congentia, and corporate and financing milestones. In addition to the milestone payments,&#160;Palvella will pay us&#160;tiered royalties from 5.0% to 9.8% based on aggregate annual worldwide net sales of any PTX-022 products, if&#160;approved, subject to Palvella&#8217;s right to reduce the royalty rates by making payments in certain circumstances. We paid Palvella an upfront payment of $10.0 million, which Palvella is required to use to fund the development of PTX-022. We will not incur any expenses to develop or commercialize PTX-022. Our director,&#160;Todd Davis, is also a director of Palvella, who beneficially owns 2% of Palvella's outstanding equity. Mr. Davis recused himself from all of the board's consideration of the purchase agreement between us and Palvella, including any financial analysis, the terms of the purchase agreement and the vote to approve the purchase agreement and the related transactions.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2017, we entered into a royalty agreement with Aziyo pursuant to which we will receive royalties from certain marketed products that Aziyo acquired from CorMatrix. Pursuant to the agreement, we received $10.0 million in 2017 from Aziyo to buydown the royalty rates on the products CorMatrix sold to Aziyo. The agreement closed on May 31, 2017, in connection with the closing of the asset sale from CorMatrix to Aziyo (the &#8220;CorMatrix Asset Sale&#8221;). Per the agreement, we will receive a 5% royalty on the products Aziyo acquired in the CorMatrix Asset Sale, reduced from the original 20% royalty from CorMatrix pursuant to the previously disclosed interest purchase agreement, dated May 3, 2016 (the &#8220;Original Interest Purchase Agreement&#8221;) between CorMatrix and us. In addition, Aziyo has agreed to pay us up to $10.0 million of additional milestones tied to cumulative net sales of the products Aziyo acquired in the CorMatrix Asset Sale and to extend the term on these royalties by one year. The royalty agreement will terminate on May 31, 2027. In addition, in May 2017, we entered into an amended and restated interest purchase agreement (the &#8220;Amended Interest Purchase Agreement&#8221;) with CorMatrix, which supersedes in its entirety the Original Interest Purchase Agreement. Other than removing the commercial products sold to Aziyo in the CorMatrix Sale, the terms of the Amended Interest Purchase Agreement remain unchanged with respect to the CorMatrix developmental pipeline products, including the royalty rate of 5% on such pipeline products. The Amended Interest Purchase Agreement will terminate 10 years from the date of the first commercial sale of such products. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for the Aziyo commercial license right as a financial asset in accordance with ASC 310 and amortize the commercial license right using the&#160;effective interest method whereby we forecast expected cash flows over the term of the arrangement to arrive at an annualized effective interest. The annual effective interest associated with the forecasted cash flows from the royalty agreement with Aziyo as of December 31, 2018 is 26%. Revenue is calculated by multiplying the carrying value of the commercial license right by the effective interest. The payments received in 2018 were accordingly allocated between revenue and the amortization of the commercial license rights.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We elected a prospective approach to account for changes in estimated cash flows and selected a method for determining when an impairment would be recognized and how to measure that impairment. In circumstances where our new estimate of expected cash flows is greater than previously expected, we will update our yield prospectively. While it has not occurred to date, in circumstances where our new estimate of expected cash flows is less than previously expected and below our original estimated yield we will record an impairment. Impairment will be recognized by reducing the financial asset to an amount that represents the present value of our most recent estimate of expected cash flows discounted by the original effective interest rate.&#160; In circumstances where our new estimate of expected cash flows is less than previously expected, but not below our original estimated yield, we will update our yield prospectively.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for commercial license rights related to developmental pipeline products on a non-accrual basis. These developmental pipeline products are non-commercialized, non-approved products that require FDA or other regulatory approval, and thus have uncertain cash flows. The developmental pipeline products are on a non-accrual basis as we are not yet able to forecast future cash flows given their pre-commercial stages of development. We will prospectively update the yield model under the effective interest method once the underlying products are commercialized and we can reliably forecast expected cash flows. Income will be calculated by multiplying the carrying value of the commercial license right by the effective interest rate.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Revenue Recognition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our revenue is generated primarily from royalties on sales of products commercialized by our partners, Captisol material sales, license fees and development, regulatory and sales based milestone payments.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 1, 2018, we adopted ASC 606 which amends the guidance for recognition of revenue from contracts with customers by using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. The results for reporting periods beginning January 1, 2018, are presented in accordance with the new standard, although comparative information has not been restated and continues to be reported under the accounting standards and policies in effect for those periods. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Upon adoption, we recorded a net decrease of&#160;$25.6 million to accumulated deficit due to the cumulative impact of adopting the new standard, with the impact related primarily to the acceleration of royalty revenue, net of related deferred tax impact. See additional information in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> subsection below. Our accounting policies under the new standard were applied prospectively and are noted below.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Royalties, License Fees and Milestones</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own&#160;under the&#160;contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment.  These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Material Sales</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize revenue when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The timing of revenue recognition, billings and cash collections results in billed accounts receivable, unbilled receivables (contract assets), and customer advances and deposits (contract liabilities) on the Consolidated Balance Sheet.  Except for royalty revenue, we generally receive payment at the point we satisfy our obligation or soon after.  Therefore, we do not generally carry a contract asset or deferred revenue balance.   </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We have revenue sharing arrangements whereby certain revenue proceeds are shared with a third party.  The revenue standard requires an entity to determine whether it is a principal or an agent in these transactions by evaluating the nature of its promise to the customer. We received a $4.6 million milestone payment from a license partner during 2018 of which $3.0 million was paid to a third-party in-licensor. We recorded net revenue of $1.6 million as we believe we are an agent in the transaction. We record amounts due to third-party in-licensors as general and administrative expenses when we are the principal in the transaction. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Disaggregation of Revenue </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under ASC 605, the legacy revenue standard, we would have reported total royalty revenue of $121.0&#160;million&#160;during 2018, disaggregated as follows: Promacta $92.3&#160;million, Kyprolis&#160;$20.9&#160;million, Evomela $5.7&#160;million, and Other $2.1&#160;million. During 2017, royalty revenue continued to be reported in accordance with ASC 605 and was $88.7 million&#160;or disaggregated as follows: Promacta $62.9 million, Kyprolis $16.4 million, Evomela $7.2 million and Other&#160;$2.2 million. During 2016, royalty revenue continued to be reported in accordance with ASC 605 and was $59.4 million&#160;or disaggregated as follows: Promacta $43.0 million, Kyprolis $12.1 million, Evomela $1.4&#160;million and Other $2.9&#160;million.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under ASC 606, royalty revenue was $128.6&#160;million&#160;during 2018 or disaggregated as follows: Promacta $99.3&#160;million, Kyprolis $21.7&#160;million, Evomela $5.7&#160;million and Other $1.9&#160;million.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands), which are not affected by the adoption of ASC 606:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.982456%;"><tr><td style="width:1.0%;"/><td style="width:31.490566%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.428931%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.900629%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.428931%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year ended December 31,&#160;</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material Sales&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Captisol&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,123&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,070&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,502&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones and other&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     License fees&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">78,195&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">13,665&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,570&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Milestones&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,577&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,093&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16,091&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Other&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,002&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,589&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">387&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93,774&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,347&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,048&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Preclinical Study and Clinical Trial Accruals</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Substantial portions of our preclinical studies and all of our clinical trials have been performed by third-party laboratories, CROs.&#160;We account for a significant portion of&#160;the clinical study costs according to the terms of our contracts with CROs. The terms of the CRO contracts may result in payment flows that do not match the periods over which services are provided to us under such contracts. Our objective is to reflect the appropriate preclinical and clinical trial expenses in our financial statements in the same period as the services occur. As part of the process of preparing our financial statements, we rely on cost information provided by our CROs. We are also required to estimate certain of our expenses resulting from the obligations under the CRO contracts. Accordingly, our preclinical study and clinical trial accrual is dependent upon the timely and accurate reporting of CROs and other third-party vendors. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate as more information becomes available concerning changing circumstances, and conditions or events that may affect such estimates.&#160;No material adjustments to preclinical study and clinical trial accrued expenses have been recognized to date.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Research and Development Expenses</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Research and development expense consists of labor, material, equipment, and allocated facilities costs of our scientific staff who are working pursuant to our collaborative agreements and other research and development projects. Also included in research and development expenses are third-party costs incurred for our research programs including in-licensing costs, CRO costs and costs incurred by other research and development service vendors. We expense these costs as they are incurred. When we make payments for research and development services prior to the services being rendered, we record those amounts as prepaid assets on our consolidated balance sheet and we expense them as the services are provided.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share-Based Compensation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We incur share-based compensation expense related to restricted stock, ESPP, and stock options.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Restricted stock unit (RSU) and performance stock unit (PSU) are all considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. We recognize share-based compensation expense based on the fair value on a straight-line basis over the requisite service periods of the awards, taking into consideration of forfeitures. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we&#160;reassess the probability of the achievement of such corporate performance goals and any expense change resulting from an adjustment in the estimated shares to be released are treated as a cumulative catch-up in the period of adjustment.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We use the Black-Scholes-Merton option-pricing model to estimate the fair value of stock purchases under ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. We&#160;look to historical and implied volatilities of our stock to determine the expected volatility. The expected term of an award is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that&#160;except for 2007, during which we declared a cash dividend on our common stock of $2.50&#160;per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future.&#160;The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We grant options,&#160;RSUs and PSUs to employees and non-employee directors. Non-employee directors are accounted for as employees. Options and RSUs granted to certain non-employee directors vest one year from the date of grant. Options granted to employees vest 1/8 on the six month anniversary of the date of grant, and 1/48 each month thereafter for forty-two months. RSUs and PSUs granted to employees vest over three years. All option awards generally expire ten years from the date of grant.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Derivatives</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2018, we issued $750.0 million aggregate principal amount of&#160;2023 Notes, bearing cash interest at a rate of 0.75%&#160;per year, payable semi-annually, as further described&#160;in &#8220;Footnote 6. Convertible Senior Notes.&#8221; Concurrently with the issuance of the notes, we entered into a series of convertible note hedge&#160;and warrant transactions which in combination are designed to reduce the potential dilution to our stockholders and/or offset the cash&#160;payments we are required to make in excess of the principal amount upon conversion of the notes. The conversion option associated with&#160;the 2023 Notes temporarily met the criteria for an embedded derivative liability which required bifurcation and separate accounting. In&#160;addition, the note hedge and warrants were also temporarily classified as a derivative asset and liability, respectively, on our consolidated balance sheet. As a result of shareholder approval to increase the number of authorized shares of our common stock on June&#160;19, 2018, as discussed in &#8220;Footnote&#160;6. Convertible Senior Notes,&#8221; the derivative asset and liabilities were reclassified to additional paid-in&#160;capital. Changes in the fair value of these derivatives prior to being classified in equity were reflected in other expense, net, in our consolidated statements of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the assets and the&#160;inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liabilities associated with the 2023 Notes:</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"/><td style="width:51.698225%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.575148%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:21.076923%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.131361%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:18.118343%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of June 19, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$187.09&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$195.91&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$248.48&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$248.48&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, warrant&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">315.38&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">315.38&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.9%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.8%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.05&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.98&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with our 2019 Notes, which we issued in August 2014 for $245.0 million aggregate principal amount, on May 22, 2018, we amended it making an irrevocable election to settle the entire note in cash. As a result, we&#160;reclassified from equity to derivative liability the fair value of the conversion premium as of May 22, 2018. Amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the corresponding convertible bond hedge. As a result, we reclassified&#160;from equity to derivative asset the fair value of the bond hedge as of May 22, 2018. Changes in the fair value of these derivatives are&#160;reflected in other expense, net, in our condensed consolidated statements of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the derivative&#160;assets and the inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liability associated with the&#160;2019 Notes:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:51.812317%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.973021%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.554252%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.973021%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:20.287390%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of December 31, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$187.09&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$135.70&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$75.05&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$75.05&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.47%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.60%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.25&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.63&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income Taxes</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize the impact of a tax position in the financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Discontinued Operations</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel. During the year ended December 31, 2016 we recognized a $1.1 million gain due to subsequent changes in certain estimates and liabilities previously recorded.  We recorded a provision for income taxes related to the gain of $0.4 million.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income (loss) Per Share</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Basic income (loss) per share is calculated by dividing net income by the weighted-average number of common shares outstanding during the period. Diluted income per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares outstanding during the period.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Potentially dilutive common shares consist of shares issuable under 2019 and 2023 convertible senior notes, stock options and restricted stock. 2019 and 2023 convertible senior notes have a dilutive impact when the average market price of the Company&#8217;s common stock exceeds the applicable conversion price of the respective notes. It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion. In addition, post May 22, 2018, the 2019 Notes can only be settled in cash and therefore there will be no further impact on income (loss) per share of these notes. Potentially dilutive common shares from stock options and restricted stock are determined using the average share price for each period under the treasury stock method. In addition, the following amounts are assumed to be used to repurchase shares: proceeds from exercise of stock options and the average amount of unrecognized compensation expense for restricted stock.  In loss periods, basic net loss per share and diluted net loss per share are identical since the effect of otherwise dilutive potential common shares is anti-dilutive and therefore excluded</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:61.343109%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares outstanding:</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,160&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,032&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dilutive potential common shares:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Restricted stock</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">72&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">141&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Stock options</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,125&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Warrants associated with 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,017&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">94&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   2019 Convertible Senior Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">693&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,214&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares used to compute diluted income per share</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,067&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,481&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Potentially dilutive shares excluded from calculation due to anti-dilutive effect</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,845&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">335&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,544&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Comprehensive Income (Loss)</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Comprehensive income (loss) represents net income (loss) adjusted for the change during the periods presented in unrealized gains and losses on available-for-sale securities, foreign currency translation adjustments, and reclassification adjustments for realized gains or losses included in net income (loss). The unrealized gains or losses are reported on the Consolidated Statements of Comprehensive Income (Loss).</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Foreign Currency Translation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">The British Pound Sterling is the functional currency of Vernalis and the corresponding financial statements have been translated into U.S. Dollars in accordance with ASC 830-30, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">Translation of Financial Statements</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">. Assets and liabilities are translated at end-of-period rates while revenues and expenses are translated at average rates in effect during the period in which the activity took place. Equity is translated at historical rates and the resulting cumulative translation adjustments are included as a component of accumulated other comprehensive income (loss).</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounting Standards Recently Adopted</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue Recognition </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In May 2014, the FASB issued new guidance related to revenue recognition, ASU 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10 and 2016-12, which outlines a comprehensive revenue recognition model and supersedes most current revenue recognition guidance. The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services. ASC 606 defines a five-step approach for recognizing revenue, which may require a company to use more judgment and make more estimates than under the current guidance. We adopted this new standard as of January 1, 2018, by using the modified-retrospective method. See </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Royalties</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Licenses Fees and Milestones</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Material Sales</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, and </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> subsections mentioned above for further information. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10), which requires equity investments (other than those accounted for under the equity method or those that result in consolidation) to be measured at fair value, with changes in fair value recognized in net income. We have strategic investments, including Viking, that fall under this guidance update. We have adopted ASU 2016-01 effective January 1, 2018 as a cumulative-effect adjustment and reclassified $2.7 million unrealized gains on equity investments, net of tax, from accumulated other comprehensive income to accumulated deficit on our consolidated balance sheet. Effective January 1, 2018, our results of operations include the changes in fair value of these financial instruments. S</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">ee &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (2), Investment in Viking</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional information.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Stock Compensation</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;font-style:italic;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718), which aims to simplify the accounting for share-based payment transactions, including accounting for income taxes, classification on the statement of cash flows, accounting for forfeitures, and classification of awards as either liabilities or equity. We have adopted this standard effective January 1, 2017. This standard increases the volatility of net income by requiring excess tax benefits from share-based payment arrangements to be classified as discrete items within the provision for income taxes, rather than recognizing excess tax benefits in additional paid-in capital. Upon adoption in the first quarter of 2017, we recorded $17.6 million to accumulated deficit on our consolidated balance sheet, primarily related to unrealized tax benefits associated with share-based compensation. Also, as a result of the adoption of this new standard, we made an accounting policy election to recognize forfeitures as they occur and will no longer estimate expected forfeitures.&#160;In addition, excess income tax benefits from share-based compensation arrangements are classified as cash flows from operations, rather than cash flows from financing activities. We elected to apply the cash flows classification guidance prospectively and have not adjusted prior periods.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Statement of Cash Flows</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In August 2016 the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments. The new standard clarifies certain aspects of the statement of cash flows, and aims to reduce diversity in practice regarding how certain transactions are classified in the statement of cash flows. This standard was effective January 1, 2018. We adopted ASU 2016-15 effective January 1, 2018. For the year ended December 31, 2017, we have reclassed&#160;$5.0 million&#160;payments to CVR holders and other contingency payments from investing activities to operating activities. For the year ended December 31, 2016, we have reclassed $8.8 million&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">payments to CVR holders and other contingency payments from investing activities to operating activities and financing activities in amount of $2.3 million and $6.5 million, respectively.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#160;In addition, in November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230), Restricted Cash. The standard requires that a statement of cash flows explains the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, restricted cash should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The new guidance is effective for interim and annual periods beginning after December 15, 2017. We adopted this standard retrospectively, effective January 1, 2018 and included restricted cash amount of&#160;$2.6 million, which was included in other current assets in our consolidated balance sheet as of December&#160;31, 2018, in the consolidated statement of cash flows. </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">See additional information in &#8220;Footnote 7. Balance Sheet Account Details.&#8221;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">We did not have any restricted cash as of December&#160;31, 2017 and&#160;2016&#160;.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounting Standards Not Yet Adopted</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Leases</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This standard requires organizations that lease assets to recognize the assets and liabilities created by those leases. The standard also will require disclosures to help investors and other financial statement users better understand the amount, timing, and uncertainty of cash flows arising from leases. The ASU becomes effective for public companies for fiscal years and interim periods within those fiscal years, beginning after December 15, 2018. In 2018, the FASB issued guidance that provides an optional transition method for adoption of this standard, which allows organizations to initially apply the new requirements at the effective date, recognize a cumulative effect adjustment to the opening balance of retained earnings, and continue to apply the legacy guidance in ASC 840, Leases,</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> including its disclosure requirements, in the comparative periods presented. We adopted this standard on January 1, 2019 by applying&#160;this optional transition method. For leases with a term of 12 months or less, we elected to not recognize lease assets and lease liabilities and expense the leases over a straight-line basis for the term of those leases. The adoption of this standards update resulted in no material impact to our balance sheet, statement of operations, equity&#160;or cash flows.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. ASU 2016-13 is effective for us beginning in the first quarter of 2020, with early adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Fair Value Measurement</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement: Disclosure Framework&#8212; Changes to the Disclosure Requirements for Fair Value Measurement (Topic 820), which modifies the disclosure requirements on fair value measurements. ASU 2018-13 is effective for us beginning in the first quarter of 2020, with earlier adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We do not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on our consolidated financial statements or disclosures.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for the organization, consolidation and basis of presentation of financial statements disclosure, and significant accounting policies of the reporting entity. May be provided in more than one note to the financial statements, as long as users are provided with an understanding of (1) the significant judgments and assumptions made by an enterprise in determining whether it must consolidate a VIE and/or disclose information about its involvement with a VIE, (2) the nature of restrictions on a consolidated VIE's assets reported by an enterprise in its statement of financial position, including the carrying amounts of such assets, (3) the nature of, and changes in, the risks associated with an enterprise's involvement with the VIE, and (4) how an enterprise's involvement with the VIE affects the enterprise's financial position, financial performance, and cash flows.  Describes procedure if disclosures are provided in more than one note to the financial statements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -URI http://asc.fasb.org/topic&amp;trid=2122149<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -URI http://asc.fasb.org/topic&amp;trid=2197479<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -URI http://asc.fasb.org/topic&amp;trid=2122369<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -URI http://asc.fasb.org/topic&amp;trid=2134479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>24
<FILENAME>R9.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817411648">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Investment in Viking<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract', window );"><strong>Organization, Consolidation and Presentation of Financial Statements [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityDisclosureTextBlock', window );">Investment in Viking</a></td>
<td class="text">Investment in Viking<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our current ownership in Viking is approximately&#160;8.8%&#160;and&#160;we account it as investment in an available-for-sale security&#160;due to the fact that 1) we do not have the ability to exercise significant&#160;influence over Viking,&#160;2) we are not involved in Viking's&#160;ongoing operations, and 3) Viking does not rely on us to provide technology products, expertise, support or services.&#160;Our investment in Viking is measured at fair value, with changes in fair value recognized in net income.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our ownership in Viking was 17.6%&#160;and 30.3%&#160;as of December 31, 2017 and 2016, respectively. As a result of Viking's public stock offerings, we recorded a dilution gain of $2.7 million and a dilution loss of $10.7 million for the years ended December 31, 2017 and 2016, respectively. These amounts were recognized in Loss from Viking in our consolidated statement of operations. Our equity ownership interest in Viking decreased during the first quarter of 2018 to approximately 12.4% due to Viking's financing events in February 2018. As a result, in February 2018, we concluded that we did not exert significant influence over Viking and discontinued accounting for our investment in Viking under the equity method. Viking is considered a related party as we maintain a seat on Viking's board of directors.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Ligand and&#160;Viking were previously parties to a Loan and Security Agreement, dated May 21, 2014 (as amended by the First&#160;Amendment to Loan and Security Agreement, dated April 8, 2015, and the Second Amendment to Loan and Security Agreement, dated&#160;January 22, 2016, the &#8220;Loan and Security Agreement&#8221;), pursuant to which we loaned $2.5 million to Viking. Such debt was&#160;evidenced by a Senior Convertible Promissory Note (the &#8220;Convertible Note&#8221;).&#160;Pursuant to the terms of the Loan and Security Agreement, upon the consummation of the Follow-On Public Offering on April 13,&#160;2016, Viking repaid us&#160;$1.5 million, which payment was composed of&#160;$0.3 million in cash, with the remaining balance paid&#160;in Viking&#8217;s equity securities, resulting in the issuance of 960,000 shares of common stock to us in the Follow-On Public&#160;Offering. Such payment was applied, first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal&#160;amount of the Convertible Note. On July 15, 2017, Viking repaid an additional $0.2 million in cash. Such payment was applied,&#160;first, to accrued and unpaid interest on the Convertible Note and, second, to the unpaid principal amount of the Convertible Note. On&#160;May 23, 2018, the Convertible Note was repurchased in full by Viking for $3.9 million in cash. As of December 31, 2018, the Convertible Note and Loan and&#160;Security Agreement are no longer outstanding.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We also have outstanding warrants to purchase 1.5 million shares of Viking's common stock at an exercise price of $1.50 per share. We recorded the warrants in other current assets in our consolidated balance sheets at fair value of $9.3 million and $3.9 million at December&#160;31, 2018 and 2017, respectively.&#160;For the years ended December&#160;31, 2018, 2017 and 2016, a gain of $5.4 million, $3.2 million and $0.3 million on the fair market value of the warrants, respectively, was included within other income. See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (4), Fair Value Measurement.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Prior to the adoption of ASU 2016-01, we reviewed our investment in Viking on a regular basis and assess whether events, changes in circumstances or the passage of time, in management's judgment, indicate that a loss in the market value of the investment may be other than temporary. This might include, but would not necessarily be limited to, the period of time during which the carrying value of our investment is significantly above the observed market value, a deterioration in Viking's financial condition, or an adverse event relating to its lead clinical programs. </span></div>Based on a sustained low Viking common stock unit price during the year ended December 31, 2016, we determined that an other than temporary decrease in the value of our investment in Viking had occurred. We wrote down the value of our&#160;investment in Viking to its estimated fair value which resulted in impairment charges of&#160;$7.4 million&#160;for the year ended December 31, 2016. Subsequent to the adoption of ASU 2016-01, we no longer account for our investment in Viking under the equity method; instead, it&#160;is measured at fair value, with changes in fair value recognized in net income.<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VariableInterestEntityDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for a variable interest entity (VIE), including but not limited to, judgments and assumptions in determining whether to consolidate and in identifying the primary beneficiary, gain (loss) recognized on the initial consolidation of the VIE, terms of arrangements, amounts and classification of the VIE's assets and liabilities, and the entity's maximum exposure to loss.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -URI http://asc.fasb.org/topic&amp;trid=2197479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VariableInterestEntityDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>25
<FILENAME>R10.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889566336">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Business Combinations<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationsAbstract', window );"><strong>Business Combinations [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationDisclosureTextBlock', window );">Business Combinations</a></td>
<td class="text">Business Combinations<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">As set forth below, we completed three acquisitions from January 1, 2016 through December 31, 2018, and all were</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> accounted for as business combinations.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> We applied&#160;the acquisition method of accounting. Accordingly, we recorded the tangible and intangible assets acquired and liabilities assumed at their estimated fair values as of the applicable date of acquisition. For each acquisition, we did not incur any material&#160;acquisition&#160;related costs.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Vernalis Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In October 2018, we acquired Vernalis, a structure-based drug discovery biotechnology company for $43.0 million, funded through cash on hand. The acquisition of Vernalis increases our overall portfolio of fully-funded programs. As&#160;Vernalis' operations are not considered material, pro forma information is not provided.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preliminary allocation of the consideration&#160;was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:97.076023%;"><tr><td style="width:1.0%;"/><td style="width:77.518072%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.481928%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash and cash equivalents&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">34,286&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,836&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other assets&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,383&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts payable and accrued liabilities&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,403)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring and product reserves&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(7,118)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(746)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Intangibles assets with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,740&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">42,978&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">None of the goodwill is deductible for tax purposes. The fair value of the core technologies were based on the discounted cash flow method that estimated the present value of the hypothetical royalty/milestone streams derived from the licensing of the related technologies.  These projected cash flows were discounted to present value using a discount rate of&#160;34.0%. The fair value of the core technology is being amortized on a straight-line basis over the weighted average estimated useful life of approximately nine years.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The estimated fair values of assets acquired and liabilities assumed, including deferred tax assets and liabilities, purchased intangibles and deferred revenue are provisional. The accounting for these amounts falls within the measurement period and therefore we may adjust these provisional amounts to reflect new information obtained about facts and circumstances that existed as of the acquisition date.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Crystal Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On October 6, 2017, we acquired all of the assets and liabilities of Crystal. Crystal is a biotechnology company focused in avian genetics and the generation of fully-human therapeutic engineering of animals for the generation of fully-human therapeutic antibodies through its OmniChicken&#174; technology. Under the terms of the agreement, we were to pay Crystal selling shareholders $27.2 million in cash including a $2.2 million&#160;working capital adjustment, and up to an additional $10.5 million&#160;of cash consideration based on Crystal&#8217;s achievement of certain research and business milestones prior to December&#160;31, 2019. In addition, Crystal&#8217;s selling shareholders will receive 10% of revenues realized by Ligand above&#160;$15 million between the closing date and December&#160;31, 2022 from&#160;existing collaboration agreements between Crystal and&#160;three&#160;of its collaborators, and Crystal&#8217;s selling shareholders will receive 20% of revenues above&#160;$1.5 million&#160;generated between the closing date and </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> December&#160;31, 2022 pursuant to a fourth existing collaboration agreement with a large pharmaceutical company. As of December&#160;31, 2018, $0.2 million of the initial $27.2 million of cash consideration remained outstanding.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At the closing of the acquisition, we recorded an&#160;$8.4 million contingent liability for amounts potentially due to Crystal shareholders. The initial fair value of the liability was determined using a probability weighted income approach incorporating the estimated future cash flows from potential milestones and revenue sharing. These cash flows were then discounted to present value using discount rates based on&#160;our estimated corporate credit rating, and averaged to approximately 4.6%. Refer to </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note 4 Fair Value Measurement </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">for further discussion. The liability has been periodically assessed based on events and circumstances related to the underlying milestones, and any changes in fair value are recorded in our consolidated statements of operations. The carrying amount of the liability may fluctuate significantly and actual amounts paid may be materially different than the carrying amount of the liability. There was no change in the fair value of the contingent liabilities from the initial valuation date to December&#160;31, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The aggregate acquisition consideration was determined to be $35.7 million, consisting of (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"/><td style="width:77.411765%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.588235%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash paid to Crystal shareholders</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash payable to Crystal Shareholders</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">336&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assumed liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">129&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of contingent consideration</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">35,743&#160;</span></td></tr></table></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:78.498534%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:17.501466%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">224&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,513&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">201&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Property and equipment, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">589&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Current liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(354)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,624)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Deferred tax liabilities, net</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(9,503)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Intangible asset with finite life - core technology</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,697&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">35,743&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The fair value of the core technology, or OmniChicken technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniChicken technology. These projected cash flows were discounted to present value using a discount rate of&#160;10.8%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of&#160;20 years.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $10.7 million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to Crystal&#8217;s potential revenue growth from combining the Crystal and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">OMT Acquisition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 8, 2016, we acquired substantially all of the assets and liabilities of OMT. OMT is a biotechnology company engaged in the genetic engineering of animals for the generation of human therapeutic antibodies through its OmniAb&#174; technology. The aggregate acquisition consideration was $173.4 million, consisting of (in thousands, except per share amounts):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"/><td style="width:77.411765%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.588235%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">96,006&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Actual number of shares issued</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">790&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Multiplied by: Ligand closing share price on January 8, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">98&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">77,373&#160;</span></td></tr><tr><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173,379&#160;</span></td></tr></table></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:78.498534%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:17.501466%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,504&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Income tax receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">136&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred tax liabilities, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(55,708)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Intangible asset with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">167,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,528)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,969&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173,379&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The fair value of the core technology, or OMT's OmniAb technology, was based on the discounted cash flow method that estimated the present value of a hypothetical royalty stream derived from the licensing of the OmniAb technology. These projected cash flows were discounted to present value using a discount rate of 15.5%.  The fair value of the core technology is being amortized on a straight-line basis over the estimated useful life of 20 years.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The excess of the acquisition date consideration over the fair values assigned to the assets acquired and the liabilities assumed was $60.0 million and was recorded as goodwill, which is not deductible for tax purposes and is primarily attributable to OMT&#8217;s potential revenue growth from combining the OMT and Ligand businesses and workforce, as well as the benefits of access to different markets and customers.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for a business combination (or series of individually immaterial business combinations) completed during the period, including background, timing, and recognized assets and liabilities. The disclosure may include leverage buyout transactions (as applicable).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -URI http://asc.fasb.org/topic&amp;trid=2303972<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>26
<FILENAME>R11.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817403728">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Fair Value Measurement<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueDisclosuresAbstract', window );"><strong>Fair Value Disclosures [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FinancialInstrumentsDisclosureTextBlock', window );">Fair Value Measurement</a></td>
<td class="text">Fair Value Measurement<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We measure certain financial assets and liabilities at fair value on a recurring basis.  Fair value is a market-based measurement that should be determined using assumptions that market participants would use in pricing an asset or liability. We establish a three-level hierarchy to prioritize the inputs used in measuring fair value. The levels are described in the below with level 1 having the highest priority and level 3 having the lowest:</span></div><div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 1 - Observable inputs such as quoted prices in active markets </span></div><div style="text-indent:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 2 - Inputs other than the quoted prices in active markets that are observable either directly or indirectly </span></div><div style="padding-left:36pt;margin-top:5pt;margin-bottom:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Level 3 - Unobservable inputs in which there is little or no market data, which require the Company to develop its own assumptions</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">647,408&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47,517&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">599,891&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">656,665&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56,774&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">599,891&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,477&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,477&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">514&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">514&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,741&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,991&#160;</span></td></tr></table></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">181,041&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,896&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Note receivable Viking </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(2)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,846&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,846&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">188,764&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,742&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,145&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,589&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,589&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,245&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,990&#160;</span></td></tr></table></div><div style="text-indent:36pt;"><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(1) Amounts Investments in equity securities (including investments in Viking), are classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities. Short-term investments in marketable securities with maturities greater than 90 days are classified as level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(2) The fair value of the Convertible Note receivable from Viking at&#160;December&#160;31, 2017&#160;approximated the book value since the contractual maturity date was within five months from the end of 2017, and there was no plan to extend the maturity date. The fair value at</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017 was determined using a probability weighted option pricing model. The fair value is subjective and is affected by certain significant input to the valuation model such as the estimated volatility of the common stock, which was estimated to be 75% at December&#160;31, 2017. Changes in these assumptions may materially affect the fair value estimate. For the years ended December&#160;31, 2018</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017, and December&#160;31, 2016, we reported an increase in the fair value of 0.0 million, an increase in the fair value of&#160;$0.9 million, and a decrease in the fair value of $0.2 million, respectively in "Other, net" of the consolidated statement of operations.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;&#160;&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(3) Investment in warrants, which we received as a result of Viking&#8217;s partial repayment of the Viking note receivable and our purchase of Viking common stock and warrants in April 2016, is classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(4) The fair value of Crystal contingent liabilities was determined using a probability weighted income approach. Most of the contingent payments are based on development or regulatory milestones as defined in the merger agreement with Crystal. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates regarding the timing and probability of achievement of certain developmental and regulatory milestones. At </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"> December&#160;31, 2018, most of the development and regulatory milestones were estimated to be highly probable of being achieved in 2019. Changes in these estimates may materially affect the fair value. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(5) The fair value of CyDex contingent liabilities was determined based on the income approach. To the extent the estimated future income may vary significantly given the long-term nature of the estimate, we utilize a Monte Carlo model. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates of timing and probability of achievement of certain revenue thresholds and developmental and regulatory milestones&#160;which may be achieved and affect amounts owed to former license holders.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(6) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-&#946; agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375.0 million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a&#160;$10.0 million payment upon initiation of a Phase 3 clinical trial. Another Metabasis drug development program, RVT-1502, has been outlicensed to Metavant. RVT-1502 is a novel, orally-bioavailable, small molecule, glucagon receptor antagonist or &#8220;GRA.&#8221; We may be entitled to up to $529.0 million in milestone payments and royalties.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(7) The liability for amounts owed to a former licensor is determined using quoted market prices in active markets for the underlying investment received from a partner, a portion of which is owed to a former licensor.</span></div><div><span><br/></span></div><div><span><br/></span></div><div><span><br/></span></div><div style="text-align:center;"><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the level 3 financial instruments as of December&#160;31, 2018 is as follows (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:81.284457%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:14.715543%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Cash payment received as repayment of note receivable</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,877)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instrument assets as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,990&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to CVR holders and other contingency payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,025)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value adjustments to contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,974)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,991&#160;</span></td></tr></table></div><div style="text-align:center;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Assets Measured on a Non-Recurring Basis</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We apply fair value techniques on a non-recurring basis associated with valuing potential impairment losses related to our&#160;goodwill,&#160;indefinite-lived intangible assets, long-lived assets, and equity investments.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We evaluate goodwill and indefinite-lived intangible assets annually for impairment and whenever circumstances occur indicating that&#160;goodwill might be impaired. We determine the fair value of our reporting unit based on a combination of inputs, including the market&#160;capitalization of Ligand, as well as Level 3 inputs such as discounted cash flows, which are not observable from the market, directly or indirectly. We determine the fair value of our indefinite-lived intangible assets using the income approach based on Level 3 inputs.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Other than certain indefinite-lived intangible asset, there were no impairment of our goodwill, indefinite-lived assets, or long-lived assets recorded during the three years ended December&#160;31, 2018,&#160;2017 and 2016.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Fair Value of Financial Instruments</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014 and May 2018, we issued the 2019 Notes and 2023 Notes, respectively. We use&#160;quoted market rates in an inactive market, which are classified as a Level 2 input, to estimate the current fair value of our 2019 and 2023 Notes. The carrying value of the notes does not reflect the market rate. See &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Note (6), Convertible Senior Notes</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional information related to the fair value.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueDisclosuresAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueDisclosuresAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FinancialInstrumentsDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for financial instruments. This disclosure includes, but is not limited to, fair value measurements of short and long term marketable securities, international currencies forward contracts, and auction rate securities. Financial instruments may include hedging and non-hedging currency exchange instruments, derivatives, securitizations and securities available for sale at fair value. Also included are investment results, realized and unrealized gains and losses as well as impairments and risk management disclosures.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FinancialInstrumentsDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>27
<FILENAME>R12.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889566336">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Lease Obligations<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesAbstract', window );"><strong>Leases [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOfLesseeDisclosureTextBlock', window );">Lease Obligations</a></td>
<td class="text">Lease Obligations<div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We lease office facilities&#160;under various operating leases. These leases expire between 2019 and 2023. Total rent expense, net under all office leases for 2018, 2017 and 2016 was $1.0 million, $0.3 million and $0.3 million, respectively.  The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of December&#160;31, 2018 (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"><tr><td style="width:1.0%;"/><td style="width:39.679627%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.577605%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.975117%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.577605%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.975117%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.044168%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:7.797823%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.044168%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.108865%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.733126%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:7.486781%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Operating lease obligations:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Lease</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Termination</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Date</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Less than 1</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">year</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1-2 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3-4 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corporate headquarters - San Diego, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2023</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">135&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">283&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">616&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">373&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">373&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Bioscience and Technology Business Center - Lawrence, KS</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 2020</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">57&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">113&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Emeryville, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">260&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">455&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">715&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Emeryville, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">203&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">351&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">554&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Winnersh, United Kingdom</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Cambridge, United Kingdom</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">September 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">549&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">549&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,620&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,963&#160;</span></td></tr><tr><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sublease payments expected to be received:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">360&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">360&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,260&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,603&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeasesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeasesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeasesOfLesseeDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for lessee entity's leasing arrangements including, but not limited to, all of the following: (a.) The basis on which contingent rental payments are determined, (b.) The existence and terms of renewal or purchase options and escalation clauses, (c.) Restrictions imposed by lease agreements, such as those concerning dividends, additional debt, and further leasing.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 842<br> -SubTopic 20<br> -URI http://asc.fasb.org/subtopic&amp;trid=77888251<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -URI http://asc.fasb.org/topic&amp;trid=2208923<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeasesOfLesseeDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>28
<FILENAME>R13.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6818602176">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Convertible Senior Notes<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtDisclosureAbstract', window );"><strong>Debt Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtDisclosureTextBlock', window );">Convertible Senior Notes</a></td>
<td class="text">Convertible Senior Notes<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">0.75% Convertible Senior Notes&#160;due 2019</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014, we issued $245.0 million aggregate principal amount of 2019&#160;Notes, resulting in net proceeds of $239.3 million. The implied estimated effective rate of the liability component of the 2019 Notes was 5.83%.&#160;The 2019 Notes are convertible into common stock at an initial conversion rate of 13.3251 shares per $1,000 principal amount of convertible notes, subject to adjustment upon certain events, which is equivalent to an initial conversion price of approximately $75.05 per share of common stock. The notes bear cash interest at a rate of 0.75% per year, payable semi-annually. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Holders of the 2019 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding May 15, 2019, under any of the following circumstances: </span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) during any fiscal quarter (and only during such fiscal quarter) commencing after December&#160;31, 2014, if,</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">for at least 20 trading days (whether or not consecutive) during the&#160;30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than 130% of the conversion price on such trading day; </span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(2) during the five business day period immediately following any&#160;10 consecutive trading day period, in which the trading price per $1,000 principal amount of notes was less than 98% of the product of the last reported sale price of our common stock on such trading day and the conversion rate on each such trading day; or </span></div><div style="padding-left:36pt;"><span><br/></span></div><div style="padding-left:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes. </span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2017, our last reported sale price of our common stock exceeded the 130% threshold described above and accordingly&#160;the 2019&#160;Notes were classified as a current liability. As a result, the related unamortized&#160;discount of $18.9 million&#160;at December 31, 2017, was classified as temporary equity component&#160;of currently redeemable convertible notes on our consolidated balance sheet.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2018, our 2019 Notes are due in less than one year, and accordingly have been&#160;classified as a current liability. Under the original indenture conversion, we were obligated to deliver cash to settle the principal and may&#160;deliver cash or shares of common stock, at our option, to settle any premium due upon conversion for any conversion notices received prior&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> to May 22, 2018. We made an irrevocable election to settle the entire&#160;note in cash&#160;per&#160;a supplemental indenture entered into on May 22, 2018. As such, we must deliver cash to settle the principal and any premium due upon conversion for any conversion notices&#160;received on or after May 22, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As a result of the requirement to deliver cash to settle any premium due upon conversion, on May 22, 2018, we reclassified from equity to liability the conversion option (a derivative) fair value of $341.6 million. In accordance with ASC 815, Derivatives and Hedging, the derivative was adjusted to its fair value as of December 31, 2018 to $23.4 million with the resulting $118.7 million increase, net of payments made, reflected in other expense, net, in our consolidated statements of operations for the year ended December 31, 2018.  </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:10pt;line-height:115%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In March and April 2018, we received notices for conversion of $21.8 million of principal amount of the 2019 Notes which were settled in&#160;May and June 2018. We paid the noteholders the conversion value of the notes in cash, up to the principal amount of the 2019 Notes. The&#160;excess of the conversion value over the principal amount, totaling&#160;$31.6 million, was paid in shares of common stock.&#160;In July and&#160;August 2018, we received notices for conversion of&#160;$195.9 million&#160;of principal amount of the 2019 Notes which were settled in October and November 2018. We paid the noteholders the&#160;$195.9 million&#160;principal amount and the excess of&#160;conversion value over the principal amount, totaling&#160;$439.6 million, in cash. The equity dilution and&#160;cash conversion premium payment&#160;upon conversion of the 2019 Notes was offset by the reacquisition of the shares and cash under the convertible bond hedge transactions entered into in connection with the offering of the 2019 Notes.&#160;As a result of the conversions, we recorded a&#160;$3.2 million loss on extinguishment of debt calculated as the difference between the estimated fair value of the debt and the carrying value of the 2019 Notes as of the settlement dates. To measure the fair value of the converted 2019 Notes as of the settlement dates, the applicable interest rates were estimated using Level 2 observable inputs and applied to the converted notes using the same methodology as in the issuance date valuation.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;&#160;</span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Convertible Bond Hedge and Warrant Transactions</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In August 2014, to minimize the impact of potential dilution to our common stock upon conversion of the 2019 Notes, we entered into convertible bond hedges and sold warrants covering 3,264,643 shares of our common stock. The convertible bond hedges have an exercise price of $75.05 per share and are exercisable when and if the 2019 Notes are converted. If upon conversion of the 2019 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into by us and are not part of the terms of the 2019 Notes. Holders of the 2019 Notes and warrants will not have any rights with respect to the convertible bond hedges. We paid $48.1 million for these convertible bond hedges and recorded the amount as a reduction to additional paid-in capital.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Conversion notices received after May 22, 2018 relating to the 2019 Notes must be fully settled in cash and amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the convertible bond hedge. As a result of the irrevocable cash election, on&#160;May 22, 2018, we reclassified from equity to derivative asset the remaining bond hedge fair value of&#160;$340.0 million and marked it to&#160;market as of December 31, 2018 to&#160;$22.6 million with the resulting $119.4 million&#160;increase, net of $471.2 million in payments received, reflected in other expense,&#160;net, in our consolidated statements of operations for the year ended December 31, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants to acquire&#160;3,264,643 shares of common stock with an exercise price of&#160;$125.08 per share, subject to certain adjustments.&#160;The warrants have various expiration dates ranging from November 13, 2019 to April 22, 2020. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise price of the warrants, as measured under the terms of the warrant transactions. We received $11.6 million for these warrants and recorded this amount to additional paid-in capital. The common stock issuable upon exercise of the warrants will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC registering the issuance of the shares under the warrants.&#160;We continue to have the ability to avoid&#160;settling the warrants associated with the 2019 Notes in cash after May 22, 2018.&#160;Accordingly, the warrants continue to be classified in&#160;additional paid in capital.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In November 2018, we modified agreements with one of the bond hedge counterparties to cash settle a total of 525,000&#160;warrants. As the modifications required the warrants to be cash settled, the fair value of the warrants was reclassified from stockholders&#8217; equity to a derivative liability on the modification dates, resulting in a $28.3 million deduction to additional paid-in-capital during 2018. We settled these repurchases for total consideration of $30.1 million and recorded a&#160;$1.8 million loss during 2018 on the change in the fair value of the derivative liabilities between their modification and settlement dates, which is included in other&#160;expense, net in the accompanying consolidated statement of operations. As a result, as of December 31, 2018,&#160;2,739,643 warrants remain outstanding.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">0.75% Convertible Senior Notes due 2023</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2018, we issued $750 million aggregate principal amount of 2023 Notes, bearing cash interest at a rate of&#160;0.75%&#160;per year, payable semi-annually. The net proceeds from the offering,&#160;after deducting the initial purchasers' discount and offering expenses, were approximately $733.1 million. The 2023 Notes will be&#160;convertible into cash, shares of common stock, or a combination of cash and shares of common stock, at our election, based on an initial&#160;conversion rate, subject to adjustment, of 4.0244 shares per $1,000 principal amount of the 2023 Notes which represents an initial&#160;conversion price of approximately $248.48 per share.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Holders of the 2023 Notes may convert the notes at any time prior to the close of business on the business day immediately preceding&#160;November 15, 2022, under any of the following circumstances:</span></div><div><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(1) during any fiscal quarter (and only during such fiscal quarter) commencing after September 30, 2018, if, for at least&#160;20&#160;trading&#160;days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately&#160;preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than&#160;130% of the&#160;conversion price on such trading day;</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(2) during the&#160;five business day period immediately following any&#160;10 consecutive trading day period, in which the trading price per&#160;$1,000 principal amount of notes was less than&#160;98% of the product of the last reported sale price of our common stock on such&#160;trading day and the conversion rate on each such trading day; or</span></div><div style="text-indent:36pt;"><span><br/></span></div><div style="text-indent:36pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">(3) upon the occurrence of certain specified corporate events as specified in the indenture governing the notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">At the May 22, 2018 issuance date of the 2023 Notes, we did not have the necessary number of authorized but unissued shares of&#160;our common stock available to settle the conversion option of the 2023 Notes in shares. Therefore, in accordance with guidance found in ASC&#160;815-15 &#8211; Embedded Derivatives, the conversion option of the Notes was deemed an embedded derivative requiring bifurcation from the&#160;2023 Notes (host contract) and separate accounting as a derivative liability. The fair value of the conversion option derivative liability at&#160;May 22, 2018 was $144.0 million, which was recorded as a reduction to the carrying value of the debt. This debt discount is amortized to&#160;interest expense over the term of the debt using the effective interest method. Up to the date in which we received shareholder approval on&#160;June 19, 2018 to increase the authorized number of shares of our common stock, the conversion option was accounted for as a liability with&#160;the resulting change in fair value of $13.5 million during that period reflected in other expense, net, in our consolidated&#160;statements of operations for the year ended December 31, 2018. As of December 31, 2018, the debt discount remains and&#160;continues to be amortized to interest expense.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The notes will have a dilutive effect to the extent the average market price per share of common stock for a given reporting period exceeds&#160;the conversion price of $248.48. As of December 31, 2018, the &#8220;if-converted value&#8221; did not exceed the principal amount of the 2023&#160;Notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the issuance of the 2023 Notes, we incurred $16.9 million of issuance costs, which primarily consisted of underwriting,&#160;legal and other professional fees. The portion of these costs allocated to the conversion option totaling&#160;$3.2 million was recorded as interest&#160;expense for the twelve months ended&#160;December&#160;31, 2018. The portion of these costs allocated to the liability component totaling&#160;$13.7 million is amortized to interest expense using the effective interest method over the five year expected life of the 2023 Notes.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the&#160;principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Convertible Bond Hedge and Warrant Transactions</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In conjunction with the 2023 Notes, in May 2018, we entered into convertible bond hedges and sold warrants covering 3,018,327 shares of&#160;our common stock to minimize the impact of potential dilution to our common stock and/or offset the cash payments we are required to&#160;make in excess of the principal amount upon conversion of the 2023 Notes. The convertible bond hedges have an exercise price of $248.48&#160;per share and are exercisable when and if the 2023 Notes are converted. We paid&#160;$140.3 million for these convertible bond hedges. If upon&#160;conversion of the 2023 Notes, the price of our common stock is above the exercise price of the convertible bond hedges, the counterparties&#160;will deliver shares of common stock and/or cash with an aggregate value approximately equal to the difference between the price of&#160;common stock at the conversion date and the exercise price, multiplied by the number of shares of common stock related to the convertible&#160;bond hedge transaction being exercised. The convertible bond hedges and warrants described below are separate transactions entered into&#160;by us and are not part of the terms of the 2023 Notes. Holders of the 2023 Notes and warrants will not have any rights with respect to the&#160;convertible bond hedges.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Concurrently with the convertible bond hedge transactions, we entered into warrant transactions whereby we sold warrants covering&#160;3,018,327 shares of common stock with an exercise price of $315.38 per share, subject to certain adjustments.&#160;We received $90.0 million for these warrants. The warrants have various expiration dates ranging from August 15, 2023 to February 6,&#160;2024. The warrants will have a dilutive effect to the extent the market price per share of common stock exceeds the applicable exercise&#160;price of the warrants, as measured under the terms of the warrant transactions. The common stock issuable upon exercise of the warrants&#160;will be in unregistered shares, and we do not have the obligation and do not intend to file any registration statement with the SEC&#160;registering the issuance of the shares under the warrants.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">For the period from May 22, 2018, the issuance date of the bond hedge and warrant transactions, to June 19, 2018, the date shareholders&#160;approved an increase in our authorized shares of common stock, the bond hedges and warrants required cash settlement and were accounted&#160;for as a derivative asset and liability, respectively, with the resulting increase in fair value of $19.2 million&#160;and $7.5 million&#160;reflected in other expense, net, in our consolidated statements of operations for twelve months ended&#160;December&#160;31, 2018.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes information about the equity and liability components of the 2019 Notes and 2023 Notes (in thousands).</span></div><div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:57.970674%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:16.768328%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:2.292669%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:16.768328%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2019 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,326&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">245,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(893)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(20,471)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total current portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,433&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">224,529&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2023 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">750,000&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(140,136)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total long-term portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">609,864&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Carrying value of equity component of 2023 Notes</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">127,997&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of convertible senior notes outstanding (Level 2)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">713,533&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">446,360&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr></table></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, there were no events of default or violation of any covenants under our financing obligations.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -URI http://asc.fasb.org/topic&amp;trid=2208564<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>29
<FILENAME>R14.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817198816">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Balance Sheet Account Details<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OtherBalanceSheetDetailsAbstract', window );"><strong>Other Balance Sheet Details [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock', window );">Balance Sheet Account Details</a></td>
<td class="text">Balance Sheet Account DetailsShort-term Investments<div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the various investment categories at December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"/><td style="width:41.088235%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cost</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">gains</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">losses</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Estimated</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">fair value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">311,066&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(29)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">311,063&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53,223&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(45)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53,179&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">135&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,191&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,326&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">225,731&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(76)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">225,663&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,982&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(9)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,973&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,017&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,013&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">600,154&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,226&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(163)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">601,217&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">80,095&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(42)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">80,059&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55,335&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(96)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55,239&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">207&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1689&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,896&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,933&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(20)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,913&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Agency bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,991&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,990&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,939&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,929&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,028&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(13)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,015&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,528&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,695&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(182)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">181,041&#160;</span></td></tr></table></div><div style="text-indent:24pt;margin-top:5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Other current assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking warrants</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,545&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,514&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,418&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,514&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and equipment is stated at cost and consists of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lab and office equipment</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,183&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,460&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Leasehold improvements</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,418&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,917&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Computer equipment and software</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">936&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">697&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,537&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,074&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less accumulated depreciation and amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,165)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,862)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,372&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,212&#160;</span></td></tr></table></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Depreciation of equipment is computed using the straight-line method over the estimated useful lives of the assets which range from three to ten years. Leasehold improvements are amortized using the straight-line method over their estimated useful lives or their related lease term, whichever is shorter. Depreciation expense of $0.9 million, $0.4 million, and $0.2 million was recognized for the years ended December&#160;31, 2018, 2017, and 2016, respectively, and is included in operating expenses.</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill and identifiable intangible assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indefinite lived intangible assets</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     IPR&amp;D</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,923&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">86,646&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">85,959&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Definite lived intangible assets</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Complete technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">235,413&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">222,900&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(35,070)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(23,301)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Trade name</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,642&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,642&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,048)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(916)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Customer relationships</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,600&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,600&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(11,744)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,264)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total goodwill and other identifiable intangible assets, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">306,439&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">314,543&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Amortization of finite lived intangible assets is computed using the straight-line method over the estimated useful life of the asset&#160;of 20 years. Amortization expense of $15.8 million, $11.3 million, and $10.6 million was recognized for the years ended December&#160;31, 2018 and&#160;2017, and 2016, respectively. Estimated amortization expense for the years ending December&#160;31, 2018 through 2023 is $13.6 million per year. For each of the years ended December&#160;31, 2018, 2017, and 2016, there was&#160;no&#160;impairment of intangible assets with finite lives.</span></div><div style="text-indent:24pt;"><span><br/></span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accrued liabilities consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Compensation</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,045&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,085&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Legal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">942&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">430&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amounts owed to former licensees</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">428&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">396&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties owed to third parties</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,025&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">954&#160;</span></td></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments due to broker for share repurchases</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,613&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Return reserve</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,590&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,093&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,464&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,512&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,200&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,377&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Contingent liabilities:</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of CyDex in January 2011, we issued a series of CVRs and also assumed certain contingent liabilities. We may be required to make additional payments upon achievement of certain clinical and regulatory milestones to the CyDex shareholders and former license holders. We paid CyDex&#160;shareholders, through 2016, 20% of all&#160;CyDex-related revenue, but only to the extent that, and beginning only when,&#160;CyDex-related revenue for the year exceeds $15.0 million; plus an additional 10% of all CyDex-related revenue recognized during such year, but only to the extent, and beginning only when aggregate CyDex-related revenue for such year exceeds $35.0 million.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with the acquisition of Metabasis in January 2010, we entered into four CVR agreements with Metabasis shareholders. The CVRs entitle the holders to cash payments as frequently as every six months as proceeds are received by us upon the sale or licensing of any of the Metabasis drug development programs and upon the achievement of specified milestones.</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes contingent liabilities&#160;as of December 2018 and 2017 (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.736842%;"><tr><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.265432%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:7.876543%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/><td colspan="3" style="display:none;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:7.413580%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Additions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cydex</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,600&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(5,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,600&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(25)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,050)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">525&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,500&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,500&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,000&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,900)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,500&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(924)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,476&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,100&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(5,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,500&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,000&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,925)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,426&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,501&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OtherBalanceSheetDetailsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Other Balance Sheet Details [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OtherBalanceSheetDetailsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SupplementalBalanceSheetDisclosuresTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -URI http://asc.fasb.org/topic&amp;trid=2122208<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SupplementalBalanceSheetDisclosuresTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>30
<FILENAME>R15.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889564320">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquityAbstract', window );"><strong>Equity [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockholdersEquityNoteDisclosureTextBlock', window );">Stockholders' Equity</a></td>
<td class="text">Stockholders&#8217; Equity<div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share-based Compensation Expense</span></div><div><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes share-based compensation expense (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:63.102639%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation expense as a component of:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development expenses</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,352&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,235&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,836&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,494&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,680&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,057&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,846&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,915&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">18,893&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Stock Plans</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2012 and May 2016, our 2002 Stock Incentive Plan was amended to increase the number of shares available for issuance by 1.8 million&#160;&#160;and 0.9 million shares, respectively.  As of December&#160;31, 2018, there were 0.6 million shares available for future option grants or direct issuance under the Amended 2002 Plan.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a summary of our stock option plan activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:48.220913%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.340206%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Exercise</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Remaining</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Contractual</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Term in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Aggregate</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Intrinsic</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">(In&#160; thousands)</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,876,332&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53.17&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.77</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">157,340&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">228,362&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">162.00&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercised</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(358,162)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55.24&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,228)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">114.53&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December 31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,736,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125,858&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercisable at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,313,374&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47.03&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.56</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">117,314&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Options vested and expected to vest as of December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,734,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125,858&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The weighted-average grant-date fair value of all stock options granted during 2018, 2017 and 2016 was $66.71, $53.17 and $46.53 per share, respectively. The total intrinsic value of all options exercised during 2018, 2017 and 2016 was approximately $51.9 million, $13.3 million and&#160;$12.0 million, respectively. </span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Cash received from options exercised, net of fees paid, in 2018, 2017 and 2016 was $19.8 million, $4.7 million and $6.2 million, respectively. </span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a further breakdown of the options outstanding as of December&#160;31, 2018:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"/><td style="width:25.366864%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.391716%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:14.568047%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Range of exercise prices</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">outstanding</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">remaining&#160; life</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">in&#160;years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercisable</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise&#160;price</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$8.58 - $10.05</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">184,702&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.87</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.00&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">184,702&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.00&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$10.12 - $12.81</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,510&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.92</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.40&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,510&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.40&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$14.47 - $14.47</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">217,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.11</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14.47&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">203,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14.47&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$16.14 - $17.88</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,790&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.17</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16.36&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,790&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16.36&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$21.92 - $21.92</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">200,372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.13</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21.92&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">200,372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21.92&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$32.00 - $56.26</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">182,767&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.70</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50.38&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">174,470&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50.10&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$63.58 - $67.53</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,434&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.44</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67.42&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,153&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67.47&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$74.42 - $74.42</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">190,825&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.12</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">74.42&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">190,825&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">74.42&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$85.79 - $100.38</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">299,282&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.57</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93.32&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">157,872&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">91.62&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$101.15 - $195.91</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">353,006&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.79</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">148.50&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">96,064&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">131.77&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,734,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,313,374&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47.03&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.538012%;"><tr><td style="width:1.0%;"/><td style="width:51.709199%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.986944%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.541840%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.541840%;"/><td style="width:0.1%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="18" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.7%-3.0%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0%-2.2%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.3%-1.9%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected volatility</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33%-36%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43%-47%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">48%-50%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected term</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.1 to 5.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.5 to 6.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.6 to 6.7 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr></table></div><div style="text-indent:27pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, there was $20.4 million of total unrecognized compensation cost related to non-vested stock options.  That cost is expected to be recognized over a weighted average period of 2.39 years.</span></div><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Restricted Stock Activity</span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following is a summary of our restricted stock activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:71.127753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.509545%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted-Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Grant&#160;Date Fair</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">133,294&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">91.60&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">62,133&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">169.92&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vested</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(61,989)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">86.19&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,165)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125.16&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">132,273&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">130.63&#160;</span></td></tr></table></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, unrecognized compensation cost related to non-vested stock awards amounted to $9.2&#160;million. That cost is expected to be recognized over a weighted average period of&#160;1.38 years.</span></div><div style="text-indent:24pt;"><span><br/></span></div><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Employee Stock Purchase Plan</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December 31, 2018, 64,008 shares of our common stock are available for future issuance under the Amended Employee Stock Purchase Plan, or ESPP.  The ESPP permits eligible employees to purchase up to 1,250 shares of Ligand common stock per calendar year at a discount through payroll deductions. The price at which stock is purchased under the ESPP is equal to 85% of the fair market value of the common stock on the first of a six month offering period or purchase date, whichever is lower. There were 3,386, 3,061 and 1,961 shares issued under the ESPP in 2018, 2017 and 2016, respectively. </span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share Repurchases </span></div>In May 2018, in conjunction with our&#160;2023 Notes debt offering,&#160;we repurchased 260,000 shares of our&#160;common stock at&#160;a cost of $191.14 per share. In September 2018, the&#160;board of directors authorized us to repurchase up to $200.0 million of our common stock&#160;from time to time over a period of up to three years&#160;(the &#8220;Repurchase Program&#8221;). As of December 31, 2018, $125.2 million remains available for repurchase under the&#160;authorized program.&#160;On January 23, 2019, the board of directors elected to increase the Repurchase Program, authorizing us to repurchase up to a maximum of $350.0 million of our outstanding common stock under the Repurchase Program. The Repurchase Program will expire, as originally scheduled, on September 20, 2021.&#160;Since December 31, 2018 and as of February 28, 2019, we acquired 400,177 additional shares during 2019, and the maximum dollar value of shares that may yet be purchased under the Repurchase Program was $225.9 million.During the years ended December&#160;31, 2018, 2017 and 2016, we repurchased 782,248 shares for $127.5 million, 14,000&#160;shares for $2.0 million, and&#160;40,500&#160;shares for&#160;$3.9 million, respectively.<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquityAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquityAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockholdersEquityNoteDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -URI http://asc.fasb.org/topic&amp;trid=2208762<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockholdersEquityNoteDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>31
<FILENAME>R16.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6885335808">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Commitments and Contingencies: Legal Proceedings<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommitmentsAndContingenciesDisclosureAbstract', window );"><strong>Commitments and Contingencies Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LegalMattersAndContingenciesTextBlock', window );">Commitments and Contingencies: Legal Proceedings</a></td>
<td class="text">Commitment and Contingencies: Legal Proceedings<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We record an estimate of a loss when the loss is considered probable and estimable. Where a liability is probable and there is a range of estimated loss and no amount in the range is more likely than any other number in the range, we record the minimum estimated liability related to the claim in accordance with </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">ASC 450, Contingencies</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">. As additional information becomes available, we assess the potential liability related to our pending litigation and revises our estimates. Revisions in the our estimates of potential liability could materially impact our results of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On July 27, 2018, AG Oncon, LLC, AG Ofcon, Ltd., Calamos Market Neutral Income Fund, Capital Ventures International, Citadel Equity Fund Ltd., Opti Opportunity Master Fund, Polygon Convertible Opportunity Master Fund, Wolverine Flagship Fund Trading Limited, as plaintiffs, filed a complaint in the Court of Chancery of the State of Delaware (AG Oncon, LLC v. Ligand Pharmaceuticals Inc.) alleging claims for violation of the Trust Indenture Act, breach of contract, damages and a declaratory judgment that the Supplemental Indenture, dated as of February 20, 2018, entered into by us and Wilmington Trust, National Association, as trustee, is invalid. On October 1, 2018, we filed a motion to dismiss the plaintiffs&#8217; complaint. The hearing on our motion is currently scheduled for April 3, 2019. We believe the allegations are completely without merit, reject all claims raised by the plaintiffs and intend to vigorously defend this matter.</span></div>In November 2017, CyDex, our wholly owned subsidiary, received a paragraph IV certification from Teva alleging that certain of our patents related to Captisol were invalid, unenforceable and/or will not be infringed by Teva&#8217;s ANDA related to Spectrum Pharmaceuticals&#8217; NDA for Evomela. On December 20, 2017, CyDex filed a complaint against Teva in the U.S. District Court for the District of Delaware, asserting that Teva&#8217;s ANDA would infringe our patents. On March 22, 2018, Teva filed an answer and counterclaims seeking declarations of non-infringement and invalidity as to each of the asserted patents and on April 12, 2018, CyDex filed an answer to Teva&#8217;s counterclaims. On July 24, 2018, the U.S. District Court entered a Scheduling Order, setting a hearing for April 1, 2019, and a trial may begin in January 2020.<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommitmentsAndContingenciesDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommitmentsAndContingenciesDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LegalMattersAndContingenciesTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for legal proceedings, legal contingencies, litigation, regulatory and environmental matters and other contingencies.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 450<br> -URI http://asc.fasb.org/topic&amp;trid=2127136<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LegalMattersAndContingenciesTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>32
<FILENAME>R17.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889564320">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxDisclosureAbstract', window );"><strong>Income Tax Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxDisclosureTextBlock', window );">Income Taxes</a></td>
<td class="text">Income Taxes<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The Tax Act was enacted on December 22, 2017 and includes a number of changes to existing tax laws that impact us, most notably it reduces the US federal corporate tax rate from 35% to 21%, for tax years beginning after December 31, 2017.&#160;The Tax Act made modifications to allowable tax depreciation, the deductability of compensation for officers, the deductibility of meals and entertainment expenses, and the deductibility of interest expense. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We remeasured our deferred tax assets and liabilities based on the impact of the federal tax rate change, recording a decrease to our net deferred tax asset balance and a corresponding increase to our income tax provision of approximately&#160;$0.6 million&#160;and $32.4 million&#160;for the year ended December 31, 2018&#160;and 2017, respectively.  We completed our accounting for the Tax Act during the fourth quarter of 2018. </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The components of the income tax expense (benefit) for continuing operations are as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.976608%;"><tr><td style="width:1.0%;"/><td style="width:65.503693%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.833973%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.686263%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current expense (benefit):</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">424&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">111&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(158)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">261&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">266&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred expense (benefit):</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,928&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,075&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,534&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(185)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">228&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(240)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,009&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,675&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,327&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of income tax expense (benefit) from continuing operations to the amount computed by applying the statutory federal income tax rate to the net income (loss) from continuing operations is summarized as follows (in thousands):</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"/><td style="width:65.941176%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.682353%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax at federal statutory rate</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,400&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,031&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,786&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State, net of federal benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,635&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">622&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">175&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">948&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">903&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,225&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(8,131)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,019)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">263&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,758)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,821)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,525)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in uncertain tax positions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">858&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,308&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,423&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Rate change for changes in federal or state law</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">178&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">32,429&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">25&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in valuation allowance</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,225)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,169)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,283&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expired NOLs and credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,054&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in derivatives</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">615&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,435&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">391&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(328)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,009&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,675&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,327&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We remeasured certain deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future, which is generally 21%. &#160;Significant components of our deferred tax assets and liabilities as of December&#160;31, 2018 and 2017 are shown below. We assess the positive and negative evidence to determine if sufficient future taxable income will be generated to use the existing deferred tax assets. Our evaluation of evidence resulted in management concluding that the majority of our&#160;deferred tax assets will be realized.  However, we maintain a valuation allowance to offset certain net deferred tax assets as management believes realization of such assets are uncertain as of December&#160;31, 2018, 2017 and 2016. The valuation allowance decreased $2.5 million in 2018, decreased $8.4 million in 2017 and increased $6.3 million in 2016.</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.175439%;"><tr><td style="width:1.0%;"/><td style="width:74.958525%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.059908%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.568049%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.213518%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands)</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating loss carryforwards</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">57,181&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">90,272&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research credit carryforwards</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">31,101&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,677&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fixed assets and intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,637&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,984&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accrued expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">657&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">845&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">957&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Capital Loss Carryforward</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,609&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,137&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,430&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,499&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">102,963&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,040&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Valuation allowance for deferred tax assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,476)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,987)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">98,487&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">136,053&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin fair value adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(179)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(243)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Convertible debt</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,905)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(737)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(44,643)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(48,237)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified indefinite lived intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,759)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,414)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,480)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(51,966)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(51,631)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred income taxes, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,521&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">84,422&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">As of December&#160;31, 2018, we had federal net operating loss carryforwards set to expire through 2037 of $229.9 million and $125.3 million of state net operating loss carryforwards. We also have&#160;$23.0 million of federal research and development credit carryforwards, which expire through 2037. We have&#160;$22.7 million of California research and development credit carryforwards that have no expiration date.&#160;&#160; </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Pursuant to Section 382 and 383 of the Internal Revenue Code of 1986, as amended, utilization of our net operating losses and credits may be subject to annual limitations in the event of any significant future changes in its ownership structure. These annual limitations may result in the expiration of net operating losses and credits prior to utilization. The deferred tax assets as of December 31, 2018 are net of any previous limitations due to Section 382 and 383.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for income taxes by evaluating a probability threshold that a tax position must meet before a financial statement benefit is recognized. The minimum threshold is a tax position that is more likely than not to be sustained upon examination by the applicable taxing authority, including resolution of any related appeals or litigation processes, based on the technical merits of the position. Our remaining liabilities for uncertain tax positions are presented net of the deferred tax asset balances on the accompanying consolidated balance sheet.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the amount of unrecognized tax benefits at December&#160;31, 2018, 2017 and 2016 is as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.029240%;"><tr><td style="width:1.0%;"/><td style="width:64.769231%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.461538%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.569231%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.461538%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.569231%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.769231%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,&#160;</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at beginning of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,363&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,770&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,452&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions based on tax positions related to the current year</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,247&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,067&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">70&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">336&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">109&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,408&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Reductions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(657)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,583)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(160)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at end of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,289&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,363&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,770&#160;</span></td></tr></table></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Included in the balance of unrecognized tax benefits at December&#160;31, 2018 is $28.2 million of tax benefits that, if recognized would impact the effective rate. There are no positions for which it is reasonably possible that the uncertain tax benefit will significantly increase or decrease within twelve months.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize interest and penalties related to uncertain tax positions in income tax expense.  As of December&#160;31, 2018 and December&#160;31, 2017, we recognized an immaterial amount of interest and penalties. We file income tax returns in the United States, various state jurisdictions, United Kingdom, and Canada with varying statutes of limitations. The federal statute of limitation remains open for the 2014 tax year to the present.&#160;The state income tax returns generally remain open for the 2013 tax year through the present.&#160; Net operating loss and research credit carryforwards arising prior to these years are also open to examination if and when utilized.</span></div><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The IRS began an audit of our 2016 tax year during the quarter ended June 30, 2018. We believe our reserve for unrecognized tax benefits and contingent tax issues is adequate with respect to all open years. Notwithstanding the foregoing, we could adjust our provision for income taxes and contingent tax liability based on future developments.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxDisclosureTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -URI http://asc.fasb.org/topic&amp;trid=2144680<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxDisclosureTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>33
<FILENAME>R18.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817404160">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Summary of Unaudited Quarterly Financial Information<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract', window );"><strong>Quarterly Financial Information Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_QuarterlyFinancialInformationTextBlock', window );">Summary of Unaudited Quarterly Financial Information</a></td>
<td class="text">Summary of Unaudited Quarterly Financial Information<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results and cash flows of interim periods. Summarized quarterly data for 2018 and 2017 are as follows (in thousands, except per share amounts):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">First Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"> Third Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fourth Quarter</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56,157&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">90,043&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">45,663&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,590&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,116&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,868&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,301&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,441&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax (expense) benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,033)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(22,419)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(11,864)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,307&#160;</span></td></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">45,279&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">73,160&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67,362&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(42,482)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.13&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.45&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.19&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2.02)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.83&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.99&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.80&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2.02)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,209&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,212&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,148&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,800&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,438&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,052&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,267&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,995&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33,375&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50,465&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,051&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,980&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16,882&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,113&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,114)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,242)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,645)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(37,674)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,079&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,058&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,426&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(7,007)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.24&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.29&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.40&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.33)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.22&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.26&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.36&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.33)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,938&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,013&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,109&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,019&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,216&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,109&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_QuarterlyFinancialInformationDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_QuarterlyFinancialInformationTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 270<br> -URI http://asc.fasb.org/topic&amp;trid=2126967<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_QuarterlyFinancialInformationTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>34
<FILENAME>R19.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6886028416">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies (Policies)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract', window );"><strong>Organization, Consolidation and Presentation of Financial Statements [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConsolidationPolicyTextBlock', window );">Principles of Consolidation</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Principles of Consolidation</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The accompanying consolidated financial statements include Ligand and its wholly-owned subsidiaries.  All significant intercompany accounts and transactions have been eliminated in consolidation.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BasisOfAccountingPolicyPolicyTextBlock', window );">Basis of Presentation</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Basis of Presentation</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our consolidated financial statements have been prepared in accordance with U.S. GAAP and include the accounts of our parent company and its wholly-owned subsidiaries. All intercompany transactions and balances have been eliminated in consolidation.</span></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PriorPeriodReclassificationAdjustmentDescription', window );">Reclassifications</a></td>
<td class="text">Reclassifications<span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Certain reclassifications have been made to the previously issued statement of operations to conform with the current period presentation. See detail in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Accounting Standards Recently Adopted</span> subsection below for further information.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UseOfEstimates', window );">Use of Estimates</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Use of Estimates</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preparation of consolidated financial statements in conformity with U.S. GAAP requires the use of estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes.  Actual results may differ from those estimates.</span></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskCreditRisk', window );">Concentrations of Business Risk</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Concentrations of Business Risk</span></div><div style="text-indent:24pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Financial instruments that potentially subject to significant concentrations of credit risk consist primarily of cash equivalents and investments. We invest&#160;excess cash principally in United States government debt securities, investment grade corporate debt securities and certificates of deposit. We have established guidelines relative to diversification and maturities that maintain safety and liquidity. These guidelines are periodically reviewed and modified to take advantage of trends in yields and interest rates.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock', window );">Cash Equivalents &amp; Short Term Investments</a></td>
<td class="text">Cash Equivalents &amp; Short Term InvestmentsCash equivalents consist of all investments with maturities of&#160;three months or less from the date of acquisition. Short-term investments primarily consist of investments in debt securities that have effective maturities greater than&#160;three&#160;months and less than twelve months from the date of acquisition. We classify our short-term investments as "available-for-sale". Such investments are carried at fair value, with unrealized gains and losses included in the statement of comprehensive income (loss).&#160;We determine the cost of investments based on the specific identification method.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock', window );">Accounts Receivable</a></td>
<td class="text"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounts Receivable</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Trade accounts receivable are recorded at the net invoice value and are not interest bearing. We consider receivables past due based on the contractual payment terms which range from 30 to 90 days. We&#160;reserve specific receivables if collectability is no longer reasonably assured. We re-evaluate such reserves on a regular basis and adjust the reserves as needed. Once a receivable is deemed to be uncollectible, such balance is charged against the reserve.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InventoryPolicyTextBlock', window );">Inventory</a></td>
<td class="text">InventoryInventory, which consists of finished goods, is stated at the lower of cost or market value. We&#160;determine cost using the first-in, first-out method. We analyze our inventory levels periodically and write down inventory to net realizable value if it has become obsolete, has a cost basis in excess of its expected net realizable value or is in excess of expected requirements.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock', window );">Property and Equipment</a></td>
<td class="text"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and Equipment</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Property and equipment are stated at cost, subject to review for impairment, and depreciated over the estimated useful lives of the assets, which generally range from three to ten years, using the straight-line method. Amortization of leasehold improvements is recorded over the shorter of the lease term or estimated useful life of the related asset. Maintenance and repairs are charged to operations as incurred. When assets are sold, or otherwise disposed of, the cost and related accumulated depreciation are removed from the accounts and any gain or loss is included in operating expense.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationsPolicy', window );">Business Combinations</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Business Combinations</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition method of accounting for business combinations requires us to use significant estimates and assumptions, including fair value estimates, as of the business combination date and to refine those estimates as necessary during the measurement period (defined as the period, not to exceed one year, in which we may adjust the provisional amounts recognized for a business combination).</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting, we recognize separately from goodwill the identifiable assets acquired, the liabilities assumed, including contingent consideration and all contractual contingencies, generally at the acquisition date fair value. Contingent purchase consideration to be settled in cash are remeasured to estimated fair value at each reporting period with the change in fair value recorded in other income (expense), net. Costs that we incur to complete the business combination such as investment banking, legal and other professional fees are not considered part of consideration and we charge them to general and administrative expense as they are incurred. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We measure goodwill as of the acquisition date as the excess of consideration transferred, which we also measure at fair value, over the net of the acquisition date amounts of the identifiable assets acquired and liabilities assumed. In addition, IPR&amp;D is capitalized and assessed for impairment annually.  IPR&amp;D is amortized upon product commercialization or upon out-licensing the underlying intellectual property where we have no active involvement in the licensee's development activities. IPR&amp;D is amortized over the estimated life of the commercial product or licensing arrangement.  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Should the initial accounting for a business combination be incomplete by the end of a reporting period that falls within the measurement period, we report provisional amounts in our financial statements. During the measurement period, we adjust the provisional amounts recognized at the acquisition date to reflect new information obtained about facts and circumstances that existed as of the acquisition date that, if known, would have affected the measurement of the amounts recognized as of that date and we record those adjustments to our financial statements in the period of change, if any.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Under the acquisition method of accounting for business combinations, if we identify changes to acquired deferred tax asset valuation allowances or liabilities related to uncertain tax positions during the measurement period and they relate to new information obtained about facts and circumstances that existed as of the acquisition date, those changes are considered a</span></div> measurement period adjustment and we record the offset to goodwill. We record all other changes to deferred tax asset valuation allowances and liabilities related to uncertain tax positions in current period income tax expense.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy', window );">Goodwill, Intangible Assets and Other Long-Lived Assets</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill, Intangible Assets and Other Long-Lived Assets</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:700;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Goodwill, which has an indefinite useful life, represents the excess of cost over fair value of net assets acquired. Goodwill is reviewed for impairment at least annually during the fourth quarter, or more frequently if an event occurs indicating the potential for impairment. During the goodwill impairment review, we assess qualitative factors to determine whether it is more likely than not that the fair value of our reporting unit is less than the carrying amount, including goodwill. We operate in one reporting unit. The qualitative factors include, but are not limited to, macroeconomic conditions, industry and market considerations, and the overall financial performance. If, after assessing the totality of these qualitative factors, we determine that it is not more likely than not that the fair value of our reporting unit is less than the carrying amount, then no additional assessment is deemed necessary. Otherwise, we proceed to perform the two-step test for goodwill impairment. The first step involves comparing the estimated fair value of the reporting unit with the carrying value, including goodwill. If the carrying amount of the reporting unit exceeds the fair value, the second step of the goodwill impairment test is performed to determine the amount of loss, which involves comparing the implied fair value of the goodwill to the carrying value of the goodwill. We may also elect to bypass the qualitative assessment in a period and elect to proceed to perform the first step of the goodwill impairment test. We performed the annual assessment for goodwill impairment during the fourth quarter of 2018, noting no impairment. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our identifiable intangible assets are typically composed of&#160;acquired core technologies, licensed technologies, customer relationships and trade names. The cost of identifiable intangible assets with finite lives is generally amortized on a straight-line basis over the assets&#8217; respective estimated useful lives. We regularly perform reviews to determine if any event has occurred that may indicate that intangible assets with finite useful lives and other long-lived assets are potentially impaired. If indicators of impairment exist, an impairment test is performed to assess the recoverability of the affected assets by determining whether the carrying amount of such assets exceeds the undiscounted expected future cash flows. If the affected assets are not recoverable, we estimate the fair value of the assets and record an impairment loss if the carrying value of the assets exceeds the fair value. Factors that may indicate potential impairment include a significant decline in our stock price and market capitalization compared to the net book value, significant changes in the ability of a particular asset to generate positive cash flows, and the pattern of utilization of a particular asset.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CommercialLicenseRightsPolicyTextBlock', window );">Commercial license rights</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Commercial license rights</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights consist of the following (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"/><td style="width:71.893805%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.537463%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, </span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo &amp; CorMatrix</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,298&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,298&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less: accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,838)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,772)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total commercial license rights, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">31,460&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,526&#160;</span></td></tr></table></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights represent a portfolio of future milestone and royalty payment rights acquired from Selexis in April 2013 and April 2015, CorMatrix in May 2016, and Pavella in December 2018. Individual commercial license rights acquired are accounted for as financial assets further discussed below. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In December 2018, we entered into a development funding and royalties agreement with Palvella.&#160;Pursuant to the agreement, we will receive up to $8.0 million of milestone payments upon the achievement by&#160;Palvella of certain regulatory milestones for PTX-022, a&#160;product candidate being developed to treat pachyonychia congentia, and corporate and financing milestones. In addition to the milestone payments,&#160;Palvella will pay us&#160;tiered royalties from 5.0% to 9.8% based on aggregate annual worldwide net sales of any PTX-022 products, if&#160;approved, subject to Palvella&#8217;s right to reduce the royalty rates by making payments in certain circumstances. We paid Palvella an upfront payment of $10.0 million, which Palvella is required to use to fund the development of PTX-022. We will not incur any expenses to develop or commercialize PTX-022. Our director,&#160;Todd Davis, is also a director of Palvella, who beneficially owns 2% of Palvella's outstanding equity. Mr. Davis recused himself from all of the board's consideration of the purchase agreement between us and Palvella, including any financial analysis, the terms of the purchase agreement and the vote to approve the purchase agreement and the related transactions.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In May 2017, we entered into a royalty agreement with Aziyo pursuant to which we will receive royalties from certain marketed products that Aziyo acquired from CorMatrix. Pursuant to the agreement, we received $10.0 million in 2017 from Aziyo to buydown the royalty rates on the products CorMatrix sold to Aziyo. The agreement closed on May 31, 2017, in connection with the closing of the asset sale from CorMatrix to Aziyo (the &#8220;CorMatrix Asset Sale&#8221;). Per the agreement, we will receive a 5% royalty on the products Aziyo acquired in the CorMatrix Asset Sale, reduced from the original 20% royalty from CorMatrix pursuant to the previously disclosed interest purchase agreement, dated May 3, 2016 (the &#8220;Original Interest Purchase Agreement&#8221;) between CorMatrix and us. In addition, Aziyo has agreed to pay us up to $10.0 million of additional milestones tied to cumulative net sales of the products Aziyo acquired in the CorMatrix Asset Sale and to extend the term on these royalties by one year. The royalty agreement will terminate on May 31, 2027. In addition, in May 2017, we entered into an amended and restated interest purchase agreement (the &#8220;Amended Interest Purchase Agreement&#8221;) with CorMatrix, which supersedes in its entirety the Original Interest Purchase Agreement. Other than removing the commercial products sold to Aziyo in the CorMatrix Sale, the terms of the Amended Interest Purchase Agreement remain unchanged with respect to the CorMatrix developmental pipeline products, including the royalty rate of 5% on such pipeline products. The Amended Interest Purchase Agreement will terminate 10 years from the date of the first commercial sale of such products. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for the Aziyo commercial license right as a financial asset in accordance with ASC 310 and amortize the commercial license right using the&#160;effective interest method whereby we forecast expected cash flows over the term of the arrangement to arrive at an annualized effective interest. The annual effective interest associated with the forecasted cash flows from the royalty agreement with Aziyo as of December 31, 2018 is 26%. Revenue is calculated by multiplying the carrying value of the commercial license right by the effective interest. The payments received in 2018 were accordingly allocated between revenue and the amortization of the commercial license rights.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We elected a prospective approach to account for changes in estimated cash flows and selected a method for determining when an impairment would be recognized and how to measure that impairment. In circumstances where our new estimate of expected cash flows is greater than previously expected, we will update our yield prospectively. While it has not occurred to date, in circumstances where our new estimate of expected cash flows is less than previously expected and below our original estimated yield we will record an impairment. Impairment will be recognized by reducing the financial asset to an amount that represents the present value of our most recent estimate of expected cash flows discounted by the original effective interest rate.&#160; In circumstances where our new estimate of expected cash flows is less than previously expected, but not below our original estimated yield, we will update our yield prospectively.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We account for commercial license rights related to developmental pipeline products on a non-accrual basis. These developmental pipeline products are non-commercialized, non-approved products that require FDA or other regulatory approval, and thus have uncertain cash flows. The developmental pipeline products are on a non-accrual basis as we are not yet able to forecast future cash flows given their pre-commercial stages of development. We will prospectively update the yield model under the effective interest method once the underlying products are commercialized and we can reliably forecast expected cash flows. Income will be calculated by multiplying the carrying value of the commercial license right by the effective interest rate.</span></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock', window );">Revenue Recognition</a></td>
<td class="text"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Revenue Recognition</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our revenue is generated primarily from royalties on sales of products commercialized by our partners, Captisol material sales, license fees and development, regulatory and sales based milestone payments.</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">On January 1, 2018, we adopted ASC 606 which amends the guidance for recognition of revenue from contracts with customers by using the modified-retrospective method applied to those contracts that were not completed as of January 1, 2018. The results for reporting periods beginning January 1, 2018, are presented in accordance with the new standard, although comparative information has not been restated and continues to be reported under the accounting standards and policies in effect for those periods. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Upon adoption, we recorded a net decrease of&#160;$25.6 million to accumulated deficit due to the cumulative impact of adopting the new standard, with the impact related primarily to the acceleration of royalty revenue, net of related deferred tax impact. See additional information in </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> subsection below. Our accounting policies under the new standard were applied prospectively and are noted below.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Royalties, License Fees and Milestones</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We receive royalty revenue on sales by our partners of products covered by patents that we or our partners own&#160;under the&#160;contractual agreements. We do not have future performance obligations under these license arrangements. We generally satisfy our obligation to grant intellectual property rights on the effective date of the contract. However, we apply the royalty recognition constraint required under the guidance for sales-based royalties which requires a sales-based royalty to be recorded no sooner than the underlying sale. Therefore, royalties on sales of products commercialized by our partners are recognized in the quarter the product is sold. Our partners generally report sales information to us on a one quarter lag. Thus, we estimate the expected royalty proceeds based on an analysis of historical experience and interim data provided by our partners including their publicly announced sales. Differences between actual and estimated royalty revenues are adjusted for in the period in which they become known, typically the following quarter. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Our contracts with customers often will include future contingent milestone based payments. We include contingent milestone based payments in the estimated transaction price when there is a basis to reasonably estimate the amount of the payment.  These estimates are based on historical experience, anticipated results and our best judgment at the time. If the contingent milestone based payment is sales-based, we apply the royalty recognition constraint and record revenue when the underlying sale has taken place. Significant judgments must be made in determining the transaction price for our sales of intellectual property. Because of the risk that products in development with our partners will not reach development based milestones or receive regulatory approval, we generally recognize any contingent payments that would be due to us upon or after the development milestone or regulatory approval.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Material Sales</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize revenue when control of Captisol material or intellectual property license rights is transferred to our customers in an amount that reflects the consideration we expect to receive from our customers in exchange for those products. This process involves identifying the contract with a customer, determining the performance obligations in the contract, determining the contract price, allocating the contract price to the distinct performance obligations in the contract, and recognizing revenue when the performance obligations have been satisfied. A performance obligation is considered distinct from other obligations in a contract when it provides a benefit to the customer either on its own or together with other resources that are readily available to the customer and is separately identified in the contract. We consider a performance obligation satisfied once we have transferred control of the product, meaning the customer has the ability to use and obtain the benefit of the Captisol material or intellectual property license right. We recognize revenue for satisfied performance obligations only when we determine there are no uncertainties regarding payment terms or transfer of control. Sales tax and other taxes we collect concurrent with revenue-producing activities are excluded from revenue. We expense incremental costs of obtaining a contract when incurred if the expected amortization period of the asset that we would have recognized is one year or less or the amount is immaterial. We did not incur any incremental costs of obtaining a contract during the periods reported.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Depending on the terms of the arrangement, we may also defer a portion of the consideration received because we have to satisfy a future obligation. We use an observable price to determine the stand-alone selling price for separate performance obligations or a cost plus margin approach when one is not available. We have elected to recognize the cost for freight and shipping when control over Captisol material has transferred to the customer as an expense in cost of material sales.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The timing of revenue recognition, billings and cash collections results in billed accounts receivable, unbilled receivables (contract assets), and customer advances and deposits (contract liabilities) on the Consolidated Balance Sheet.  Except for royalty revenue, we generally receive payment at the point we satisfy our obligation or soon after.  Therefore, we do not generally carry a contract asset or deferred revenue balance.   </span></div>We have revenue sharing arrangements whereby certain revenue proceeds are shared with a third party.  The revenue standard requires an entity to determine whether it is a principal or an agent in these transactions by evaluating the nature of its promise to the customer. We received a $4.6 million milestone payment from a license partner during 2018 of which $3.0 million was paid to a third-party in-licensor. We recorded net revenue of $1.6 million as we believe we are an agent in the transaction. We record amounts due to third-party in-licensors as general and administrative expenses when we are the principal in the transaction.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock', window );">Preclinical Study and Clinical Trial Accruals</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Preclinical Study and Clinical Trial Accruals</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Substantial portions of our preclinical studies and all of our clinical trials have been performed by third-party laboratories, CROs.&#160;We account for a significant portion of&#160;the clinical study costs according to the terms of our contracts with CROs. The terms of the CRO contracts may result in payment flows that do not match the periods over which services are provided to us under such contracts. Our objective is to reflect the appropriate preclinical and clinical trial expenses in our financial statements in the same period as the services occur. As part of the process of preparing our financial statements, we rely on cost information provided by our CROs. We are also required to estimate certain of our expenses resulting from the obligations under the CRO contracts. Accordingly, our preclinical study and clinical trial accrual is dependent upon the timely and accurate reporting of CROs and other third-party vendors. We periodically evaluate our estimates to determine if adjustments are necessary or appropriate as more information becomes available concerning changing circumstances, and conditions or events that may affect such estimates.&#160;No material adjustments to preclinical study and clinical trial accrued expenses have been recognized to date.</span></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ResearchAndDevelopmentExpensePolicy', window );">Research and Development Expenses</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Research and Development Expenses</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Research and development expense consists of labor, material, equipment, and allocated facilities costs of our scientific staff who are working pursuant to our collaborative agreements and other research and development projects. Also included in research and development expenses are third-party costs incurred for our research programs including in-licensing costs, CRO costs and costs incurred by other research and development service vendors. We expense these costs as they are incurred. When we make payments for research and development services prior to the services being rendered, we record those amounts as prepaid assets on our consolidated balance sheet and we expense them as the services are provided.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy', window );">Share-Based Compensation</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Share-Based Compensation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We incur share-based compensation expense related to restricted stock, ESPP, and stock options.</span></div><div style="text-indent:45pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Restricted stock unit (RSU) and performance stock unit (PSU) are all considered restricted stock. The fair value of restricted stock is determined by the closing market price of our common stock on the date of grant. We recognize share-based compensation expense based on the fair value on a straight-line basis over the requisite service periods of the awards, taking into consideration of forfeitures. PSU represents a right to receive a certain number of shares of common stock based on the achievement of corporate performance goals and continued employment during the vesting period. At each reporting period, we&#160;reassess the probability of the achievement of such corporate performance goals and any expense change resulting from an adjustment in the estimated shares to be released are treated as a cumulative catch-up in the period of adjustment.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We use the Black-Scholes-Merton option-pricing model to estimate the fair value of stock purchases under ESPP and stock options granted. The model assumptions include expected volatility, term, dividends, and the risk-free interest rate. We&#160;look to historical and implied volatilities of our stock to determine the expected volatility. The expected term of an award is based on historical forfeiture experience, exercise activity, and on the terms and conditions of the stock awards. The expected dividend yield is determined to be 0% given that&#160;except for 2007, during which we declared a cash dividend on our common stock of $2.50&#160;per share, we have not paid any dividends on our common stock in the past and currently do not expect to pay cash dividends or make any other distributions on common stock in the future.&#160;The risk-free interest rate is based upon U.S. Treasury securities with remaining terms similar to the expected term of the share-based awards.</span></div><div style="text-indent:22.5pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We grant options,&#160;RSUs and PSUs to employees and non-employee directors. Non-employee directors are accounted for as employees. Options and RSUs granted to certain non-employee directors vest one year from the date of grant. Options granted to employees vest 1/8 on the six month anniversary of the date of grant, and 1/48 each month thereafter for forty-two months. RSUs and PSUs granted to employees vest over three years. All option awards generally expire ten years from the date of grant.</span></div>Share-based compensation expense for awards to employees and non-employee directors is recognized on a straight-line basis over the vesting period until the last tranche vests.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxPolicyTextBlock', window );">Income Taxes</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income Taxes</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in the provision for income taxes in the period that includes the enactment date. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Deferred tax assets are regularly assessed to determine the likelihood they will be recovered from future taxable income. A valuation allowance is established when we believe it is more likely than not the future realization of all or some of a deferred tax asset will not be achieved. In evaluating the ability to recover deferred tax assets within the jurisdiction which they arise we consider all available positive and negative evidence. Factors reviewed include the cumulative pre-tax book income for the past three years, scheduled reversals of deferred tax liabilities, history of earnings and reliable forecasting, projections of pre-tax book income over the foreseeable future, and the impact of any feasible and prudent tax planning strategies.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We recognize the impact of a tax position in the financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationsPolicyTextBlock', window );">Discontinued Operations</a></td>
<td class="text">Discontinued OperationsIn 2006, we entered into a purchase agreement with Eisai pursuant to which Eisai agreed to acquire our Oncology product line which included four marketed oncology drugs: ONTAK, Targretin capsules, Targretin gel and Panretin gel.<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerSharePolicyTextBlock', window );">Income (Loss) Per Share</a></td>
<td class="text"><div style="margin-top:14pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Income (loss) Per Share</span></div><div style="text-indent:36pt;"><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Basic income (loss) per share is calculated by dividing net income by the weighted-average number of common shares outstanding during the period. Diluted income per share is computed based on the sum of the weighted average number of common shares and potentially dilutive common shares outstanding during the period. Diluted loss per share is computed based on the sum of the weighted average number of common shares outstanding during the period.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">Potentially dilutive common shares consist of shares issuable under 2019 and 2023 convertible senior notes, stock options and restricted stock. 2019 and 2023 convertible senior notes have a dilutive impact when the average market price of the Company&#8217;s common stock exceeds the applicable conversion price of the respective notes. It is our intent and policy to settle conversions through combination settlement, which essentially involves payment in cash equal to the principal portion and delivery of shares of common stock for the excess of the conversion value over the principal portion. In addition, post May 22, 2018, the 2019 Notes can only be settled in cash and therefore there will be no further impact on income (loss) per share of these notes. Potentially dilutive common shares from stock options and restricted stock are determined using the average share price for each period under the treasury stock method. In addition, the following amounts are assumed to be used to repurchase shares: proceeds from exercise of stock options and the average amount of unrecognized compensation expense for restricted stock.  In loss periods, basic net loss per share and diluted net loss per share are identical since the effect of otherwise dilutive potential common shares is anti-dilutive and therefore excluded</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock', window );">Comprehensive Income (Loss)</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Comprehensive Income (Loss)</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Comprehensive income (loss) represents net income (loss) adjusted for the change during the periods presented in unrealized gains and losses on available-for-sale securities, foreign currency translation adjustments, and reclassification adjustments for realized gains or losses included in net income (loss). The unrealized gains or losses are reported on the Consolidated Statements of Comprehensive Income (Loss).</span></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock', window );">Foreign Currency Translation</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Foreign Currency Translation</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">The British Pound Sterling is the functional currency of Vernalis and the corresponding financial statements have been translated into U.S. Dollars in accordance with ASC 830-30, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:115%;">Translation of Financial Statements</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:115%;">. Assets and liabilities are translated at end-of-period rates while revenues and expenses are translated at average rates in effect during the period in which the activity took place. Equity is translated at historical rates and the resulting cumulative translation adjustments are included as a component of accumulated other comprehensive income (loss).</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock', window );">Accounting Standards Recently Adopted and Accounting Standards Not Yet Adopted</a></td>
<td class="text">Accounting Standards Recently Adopted<div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue Recognition </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In May 2014, the FASB issued new guidance related to revenue recognition, ASU 2014-09, Revenue from Contracts with Customers (Topic 606), and the amendments in ASUs 2015-14, 2016-10 and 2016-12, which outlines a comprehensive revenue recognition model and supersedes most current revenue recognition guidance. The new guidance requires a company to recognize revenue upon transfer of goods or services to a customer at an amount that reflects the expected consideration to be received in exchange for those goods or services. ASC 606 defines a five-step approach for recognizing revenue, which may require a company to use more judgment and make more estimates than under the current guidance. We adopted this new standard as of January 1, 2018, by using the modified-retrospective method. See </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Royalties</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Licenses Fees and Milestones</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Material Sales</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">, and </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Disaggregation of Revenue</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> subsections mentioned above for further information. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10), which requires equity investments (other than those accounted for under the equity method or those that result in consolidation) to be measured at fair value, with changes in fair value recognized in net income. We have strategic investments, including Viking, that fall under this guidance update. We have adopted ASU 2016-01 effective January 1, 2018 as a cumulative-effect adjustment and reclassified $2.7 million unrealized gains on equity investments, net of tax, from accumulated other comprehensive income to accumulated deficit on our consolidated balance sheet. Effective January 1, 2018, our results of operations include the changes in fair value of these financial instruments. S</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">ee &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Item 8. Financial Statements and Supplementary Data&#8212;Notes to Consolidated Financial Statements&#8212;Note (2), Investment in Viking</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#8221; for additional information.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Stock Compensation</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Arial;font-size:12pt;font-style:italic;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">- In March 2016, the FASB issued ASU 2016-09, Compensation - Stock Compensation (Topic 718), which aims to simplify the accounting for share-based payment transactions, including accounting for income taxes, classification on the statement of cash flows, accounting for forfeitures, and classification of awards as either liabilities or equity. We have adopted this standard effective January 1, 2017. This standard increases the volatility of net income by requiring excess tax benefits from share-based payment arrangements to be classified as discrete items within the provision for income taxes, rather than recognizing excess tax benefits in additional paid-in capital. Upon adoption in the first quarter of 2017, we recorded $17.6 million to accumulated deficit on our consolidated balance sheet, primarily related to unrealized tax benefits associated with share-based compensation. Also, as a result of the adoption of this new standard, we made an accounting policy election to recognize forfeitures as they occur and will no longer estimate expected forfeitures.&#160;In addition, excess income tax benefits from share-based compensation arrangements are classified as cash flows from operations, rather than cash flows from financing activities. We elected to apply the cash flows classification guidance prospectively and have not adjusted prior periods.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:400;line-height:120%;">Statement of Cash Flows</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;"> - In August 2016 the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments. The new standard clarifies certain aspects of the statement of cash flows, and aims to reduce diversity in practice regarding how certain transactions are classified in the statement of cash flows. This standard was effective January 1, 2018. We adopted ASU 2016-15 effective January 1, 2018. For the year ended December 31, 2017, we have reclassed&#160;$5.0 million&#160;payments to CVR holders and other contingency payments from investing activities to operating activities. For the year ended December 31, 2016, we have reclassed $8.8 million&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">payments to CVR holders and other contingency payments from investing activities to operating activities and financing activities in amount of $2.3 million and $6.5 million, respectively.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">&#160;In addition, in November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230), Restricted Cash. The standard requires that a statement of cash flows explains the change during the period in the total of cash, cash equivalents, and amounts generally described as restricted cash or restricted cash equivalents. Therefore, restricted cash should be included with cash and cash equivalents when reconciling the beginning-of-period and end-of-period total amounts shown on the statement of cash flows. The new guidance is effective for interim and annual periods beginning after December 15, 2017. We adopted this standard retrospectively, effective January 1, 2018 and included restricted cash amount of&#160;$2.6 million, which was included in other current assets in our consolidated balance sheet as of December&#160;31, 2018, in the consolidated statement of cash flows. </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">See additional information in &#8220;Footnote 7. Balance Sheet Account Details.&#8221;&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:120%;">We did not have any restricted cash as of December&#160;31, 2017 and&#160;2016&#160;.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accounting Standards Not Yet Adopted</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Leases</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842). This standard requires organizations that lease assets to recognize the assets and liabilities created by those leases. The standard also will require disclosures to help investors and other financial statement users better understand the amount, timing, and uncertainty of cash flows arising from leases. The ASU becomes effective for public companies for fiscal years and interim periods within those fiscal years, beginning after December 15, 2018. In 2018, the FASB issued guidance that provides an optional transition method for adoption of this standard, which allows organizations to initially apply the new requirements at the effective date, recognize a cumulative effect adjustment to the opening balance of retained earnings, and continue to apply the legacy guidance in ASC 840, Leases,</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> including its disclosure requirements, in the comparative periods presented. We adopted this standard on January 1, 2019 by applying&#160;this optional transition method. For leases with a term of 12 months or less, we elected to not recognize lease assets and lease liabilities and expense the leases over a straight-line basis for the term of those leases. The adoption of this standards update resulted in no material impact to our balance sheet, statement of operations, equity&#160;or cash flows.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Financial Instruments</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In June 2016, the FASB issued ASU 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (Topic 326), which amends the impairment model by requiring entities to use a forward-looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. ASU 2016-13 is effective for us beginning in the first quarter of 2020, with early adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;line-height:120%;">Fair Value Measurement</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;"> - In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement: Disclosure Framework&#8212; Changes to the Disclosure Requirements for Fair Value Measurement (Topic 820), which modifies the disclosure requirements on fair value measurements. ASU 2018-13 is effective for us beginning in the first quarter of 2020, with earlier adoption permitted. We are currently evaluating the impact of this ASU on our consolidated financial statements.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">We do not believe that any other recently issued, but not yet effective accounting pronouncements, if adopted, would have a material impact on our consolidated financial statements or disclosures.</span></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Allowance for doubtful accounts.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash, Cash Equivalents, and Short-term Investments [Policy Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CommercialLicenseRightsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Commercial License Rights [Policy Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CommercialLicenseRightsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Preclinical Study and Clinical Trial Accruals [Policy Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BasisOfAccountingPolicyPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for basis of accounting, or basis of presentation, used to prepare the financial statements (for example, US Generally Accepted Accounting Principles, Other Comprehensive Basis of Accounting, IFRS).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BasisOfAccountingPolicyPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationsPolicy">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for completed business combinations (purchase method, acquisition method or combination of entities under common control). This accounting policy may include a general discussion of the purchase method or acquisition method of accounting (including for example, the treatment accorded contingent consideration, the identification of assets and liabilities, the purchase price allocation process, how the fair values of acquired assets and liabilities are determined) and the entity's specific application thereof. An entity that acquires another entity in a leveraged buyout transaction generally discloses the accounting policy followed by the acquiring entity in determining the basis used to value its interest in the acquired entity, and the rationale for that accounting policy.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 10<br> -Section 05<br> -Paragraph 4<br> -Subparagraph (a)-(d)<br> -URI http://asc.fasb.org/extlink&amp;oid=6909625&amp;loc=d3e227-128457<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationsPolicy</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ComprehensiveIncomePolicyPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for comprehensive income.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ComprehensiveIncomePolicyPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConcentrationRiskCreditRisk">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for credit risk.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e5967-108592<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 825<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=108315417&amp;loc=d3e61044-112788<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConcentrationRiskCreditRisk</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConsolidationPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy regarding (1) the principles it follows in consolidating or combining the separate financial statements, including the principles followed in determining the inclusion or exclusion of subsidiaries or other entities in the consolidated or combined financial statements and (2) its treatment of interests (for example, common stock, a partnership interest or other means of exerting influence) in other entities, for example consolidation or use of the equity or cost methods of accounting.  The accounting policy may also address the accounting treatment for intercompany accounts and transactions, noncontrolling interest, and the income statement treatment in consolidation for issuances of stock by a subsidiary.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.3A-02)<br> -URI http://asc.fasb.org/extlink&amp;oid=27015204&amp;loc=d3e355033-122828<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section S99<br> -Paragraph 3<br> -Subparagraph (SX 210.3A-03)<br> -URI http://asc.fasb.org/extlink&amp;oid=27015204&amp;loc=d3e355100-122828<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109239629&amp;loc=d3e5614-111684<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConsolidationPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for discontinued operations. Includes, but is not limited to, method of interest allocation to a discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=d3e1361-107760<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section S99<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=26872618&amp;loc=d3e7436-122677<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerSharePolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for computing basic and diluted earnings or loss per share for each class of common stock and participating security. Addresses all significant policy factors, including any antidilutive items that have been excluded from the computation and takes into account stock dividends, splits and reverse splits that occur after the balance sheet date of the latest reporting period but before the issuance of the financial statements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3630-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerSharePolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for (1) transactions denominated in a currency other than the reporting enterprise's functional currency, (2) translating foreign currency financial statements that are incorporated into the financial statements of the reporting enterprise by consolidation, combination, or the equity method of accounting, and (3) remeasurement of the financial statements of a foreign reporting enterprise in a hyperinflationary economy.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 830<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6450520&amp;loc=d3e32583-110901<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 830<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6450222&amp;loc=d3e30840-110895<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for goodwill. This accounting policy also may address how an entity assesses and measures impairment of goodwill, how reporting units are determined, how goodwill is allocated to such units, and how the fair values of the reporting units are determined.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=108376223&amp;loc=d3e13816-109267<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for income taxes, which may include its accounting policies for recognizing and measuring deferred tax assets and liabilities and related valuation allowances, recognizing investment tax credits, operating loss carryforwards, tax credit carryforwards, and other carryforwards, methodologies for determining its effective income tax rate and the characterization of interest and penalties in the financial statements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32847-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 954<br> -SubTopic 740<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6491622&amp;loc=d3e9504-115650<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 17<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32809-109319<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 19<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32840-109319<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e32247-109318<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e32280-109318<br><br>Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 30<br> -Section 05<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=65884525&amp;loc=d3e40913-109327<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InventoryPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of inventory accounting policy for inventory classes, including, but not limited to, basis for determining inventory amounts, methods by which amounts are added and removed from inventory classes, loss recognition on impairment of inventories, and situations in which inventories are stated above cost.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=66092785&amp;loc=d3e4556-108314<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6361739&amp;loc=d3e7789-107766<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 270<br> -SubTopic 10<br> -Section 45<br> -Paragraph 6<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109236672&amp;loc=d3e543-108305<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=66092785&amp;loc=d3e4492-108314<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.6(b))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InventoryPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy pertaining to new accounting pronouncements that may impact the entity's financial reporting. Includes, but is not limited to, quantification of the expected or actual impact.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PriorPeriodReclassificationAdjustmentDescription">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for reclassifications that affects the comparability of the financial statements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6359566&amp;loc=d3e326-107755<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PriorPeriodReclassificationAdjustmentDescription</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for long-lived, physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, basis of assets, depreciation and depletion methods used, including composite deprecation, estimated useful lives, capitalization policy, accounting treatment for costs incurred for repairs and maintenance, capitalized interest and the method it is calculated, disposals and impairments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.13(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ResearchAndDevelopmentExpensePolicy">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for costs it has incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 730<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6420194&amp;loc=d3e21568-108373<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ResearchAndDevelopmentExpensePolicy</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenueFromContractWithCustomerPolicyTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for revenue from contract with customer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18823-107790<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -URI http://asc.fasb.org/topic&amp;trid=49130388<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenueFromContractWithCustomerPolicyTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for stock option and stock incentive plans. This disclosure may include (1) the types of stock option or incentive plans sponsored by the entity (2) the groups that participate in (or are covered by) each plan (3) significant plan provisions and (4) how stock compensation is measured, and the methodologies and significant assumptions used to determine that measurement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=84158767&amp;loc=d3e18780-107790<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b),(f)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5047-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UseOfEstimates">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Disclosure of accounting policy for the use of estimates in the preparation of financial statements in conformity with generally accepted accounting principles.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6191-108592<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6161-108592<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6143-108592<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e5967-108592<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6061-108592<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6132-108592<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e5967-108592<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UseOfEstimates</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>35
<FILENAME>R20.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6885780656">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract', window );"><strong>Organization, Consolidation and Presentation of Financial Statements [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock', window );">Schedule of Major Customers</a></td>
<td class="text">Revenue from significant partners, which is defined as 10% or more of our total revenue, was as follows:<table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:52.344624%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.727541%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:9pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner A</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">40&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">41&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner B</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">13&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Partner C</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; 10%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&lt; 10%&#160;</span></td></tr></table><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock', window );">Schedule of Commercial License Rights</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Commercial license rights consist of the following (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.122807%;"><tr><td style="width:1.0%;"/><td style="width:71.893805%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.537463%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.684366%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, </span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Aziyo &amp; CorMatrix</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17,696&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Palvella</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Selexis</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,602&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,298&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,298&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less: accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,838)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,772)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total commercial license rights, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">31,460&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,526&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueTableTextBlock', window );">Schedule of Disaggregation of Revenue</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table represents disaggregation of Material Sales and License fees, milestone and other (in thousands), which are not affected by the adoption of ASC 606:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:92.982456%;"><tr><td style="width:1.0%;"/><td style="width:31.490566%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.428931%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.900629%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.428931%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.383648%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year ended December 31,&#160;</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Material Sales&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Captisol&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,123&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,070&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,502&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">License fees, milestones and other&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     License fees&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">78,195&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">13,665&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,570&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Milestones&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,577&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,093&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16,091&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Other&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,002&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,589&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">387&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93,774&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,347&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,048&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock', window );">Schedule of Inputs and Assumptions Used to Calculate Fair Value of Derivatives</a></td>
<td class="text">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the assets and the&#160;inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liabilities associated with the 2023 Notes:<div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"/><td style="width:51.698225%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.575148%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:21.076923%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.131361%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:18.118343%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of June 19, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$187.09&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$195.91&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$248.48&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$248.48&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, warrant&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">315.38&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">315.38&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.9%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.8%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.05&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.98&#160;</span></td></tr></table></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">In connection with our 2019 Notes, which we issued in August 2014 for $245.0 million aggregate principal amount, on May 22, 2018, we amended it making an irrevocable election to settle the entire note in cash. As a result, we&#160;reclassified from equity to derivative liability the fair value of the conversion premium as of May 22, 2018. Amounts paid in excess of the&#160;principal amount will be offset by an equal receipt of cash under the corresponding convertible bond hedge. As a result, we reclassified&#160;from equity to derivative asset the fair value of the bond hedge as of May 22, 2018. Changes in the fair value of these derivatives are&#160;reflected in other expense, net, in our condensed consolidated statements of operations.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the inputs and assumptions used in the Black-Scholes model to calculate the fair value of the derivative&#160;assets and the inputs and assumptions used in the Binomial model to calculate the fair value of the derivative liability associated with the&#160;2019 Notes:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span></div><div><span><br/></span></div><div><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:51.812317%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.973021%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:19.554252%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.973021%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:20.287390%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of May 22, 2018&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">As of December 31, 2018&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Common stock price&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$187.09&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$135.70&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercise price, conversion premium and bond hedge&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$75.05&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$75.05&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.47%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.60%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Volatility&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30%-35%&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dividend yield&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Annual coupon rate&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:top;padding-left:1pt;padding-right:0%;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.75%&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:top;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Remaining contractual term (in years)&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.25&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.63&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock', window );">Schedule of Computation of Basic and Diluted Net Income (Loss) per Share</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table presents the calculation of weighted average shares used to calculate basic and diluted earnings per share (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:61.343109%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.730205%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares outstanding:</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,160&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,032&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Dilutive potential common shares:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Restricted stock</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">72&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">141&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Stock options</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,125&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,000&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   Warrants associated with 2019 Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,017&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">94&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">   2019 Convertible Senior Notes</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">693&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,214&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares used to compute diluted income per share</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,067&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,481&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,831&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Potentially dilutive shares excluded from calculation due to anti-dilutive effect</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,845&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">335&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,544&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ScheduleofCommercialLicenseRightsTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Schedule of Commercial License Rights [Table Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ScheduleofCommercialLicenseRightsTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DisaggregationOfRevenueTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130545-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DisaggregationOfRevenueTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfDerivativeInstrumentsTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of pertinent information about a derivative or group of derivatives on a disaggregated basis, such as for individual instruments, or small groups of similar instruments. May include a combination of the type of instrument, risks being hedged, notional amount, hedge designation, related hedged item, inception date, maturity date, or other relevant item.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4B<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5624163-113959<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1B<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5580258-113959<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=d3e41620-113959<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1A<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5579245-113959<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=d3e41638-113959<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=d3e41678-113959<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=d3e41641-113959<br><br>Reference 8: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4C<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5624171-113959<br><br>Reference 9: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(n)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5579240-113959<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfDerivativeInstrumentsTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the nature of a concentration, a benchmark to which it is compared, and the percentage that the risk is to the benchmark.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 50<br> -Paragraph 21<br> -URI http://asc.fasb.org/extlink&amp;oid=109250915&amp;loc=d3e13537-108611<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 50<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=109250915&amp;loc=d3e13531-108611<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6404-108592<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 16<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6327-108592<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 18<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6351-108592<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 21<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6442-108592<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>36
<FILENAME>R21.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6884710736">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Business Combinations (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember', window );">Vernalis</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock', window );">Schedule of Recognized Identified Assets Acquired and Liabilities Assumed</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The preliminary allocation of the consideration&#160;was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:97.076023%;"><tr><td style="width:1.0%;"/><td style="width:77.518072%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.481928%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash and cash equivalents&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">34,286&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,836&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other assets&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,383&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accounts payable and accrued liabilities&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,403)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring and product reserves&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(7,118)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(746)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Intangibles assets with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#ffffff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,740&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;border-bottom:3pt double #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">42,978&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock', window );">Schedule of Recognized Identified Assets Acquired and Liabilities Assumed</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:78.498534%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:17.501466%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">224&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,513&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">201&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Property and equipment, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">589&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Current liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(354)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,624)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Deferred tax liabilities, net</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(9,503)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">     Intangible asset with finite life - core technology</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,697&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">35,743&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock', window );">Schedule of Business Acquisitions</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The aggregate acquisition consideration was determined to be $35.7 million, consisting of (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"/><td style="width:77.411765%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.588235%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash paid to Crystal shareholders</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash payable to Crystal Shareholders</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">336&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assumed liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">129&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of contingent consideration</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">35,743&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member', window );">OMT</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock', window );">Schedule of Recognized Identified Assets Acquired and Liabilities Assumed</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The acquisition consideration was allocated to the acquisition date fair values of acquired assets and assumed liabilities as follows (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:78.498534%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:17.501466%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Cash and cash equivalents</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,504&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Accounts receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Income tax receivable</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">136&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Prepaid expenses and other current assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Deferred tax liabilities, net</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(55,708)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Intangible asset with finite life - core technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">167,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Liabilities assumed</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,528)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,969&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173,379&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock', window );">Schedule of Business Acquisitions</a></td>
<td class="text">The aggregate acquisition consideration was $173.4 million, consisting of (in thousands, except per share amounts):<table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.444444%;"><tr><td style="width:1.0%;"/><td style="width:77.411765%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:18.588235%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cash consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">96,006&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Actual number of shares issued</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">790&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">  Multiplied by: Ligand closing share price on January 8, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">98&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total share consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">77,373&#160;</span></td></tr><tr><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:5pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total consideration</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">173,379&#160;</span></td></tr></table><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Schedule of Business Acquisitions by Acquisition, Consideration Transferred [Table Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the amounts recognized as of the acquisition date for each major class of assets acquired and liabilities assumed. May include but not limited to the following: (a) acquired receivables; (b) contingencies recognized at the acquisition date; and (c) the fair value of noncontrolling interests in the acquiree.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>37
<FILENAME>R22.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6884269040">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Fair Value Measurement (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueDisclosuresAbstract', window );"><strong>Fair Value Disclosures [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock', window );">Schedule of Assets and Liabilities Measured on Recurring Basis</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table provides a summary of the assets and liabilities that are measured at fair value on a recurring basis as of December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">647,408&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47,517&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">599,891&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">656,665&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56,774&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">599,891&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,477&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,477&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">514&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">514&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,741&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">199&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,991&#160;</span></td></tr></table></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="24" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Measurements at Reporting Date Using</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Quoted Prices in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Active Markets</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">for Identical</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Assets</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Other</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Observable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Significant</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Unobservable</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Inputs</span></div></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;2)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(Level&#160;3)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Short-term investments</span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;"> (1)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">181,041&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,896&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Note receivable Viking </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(2)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Investment in warrants </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(3)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,846&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,846&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">188,764&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,742&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,145&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Crystal </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">4</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,401&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Cydex </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">5</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,589&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,589&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Contingent liabilities - Metabasis </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">6</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Liability for amounts owed to a former licensor </span><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">(</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">7</sup><sup style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:6.5pt;font-weight:400;line-height:100%;vertical-align:top;">)</sup></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Total liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,245&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">284&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,971&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,990&#160;</span></td></tr></table></div><div style="text-indent:36pt;"><span><br/></span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(1) Amounts Investments in equity securities (including investments in Viking), are classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities. Short-term investments in marketable securities with maturities greater than 90 days are classified as level 2 of the fair value hierarchy, as these investment securities are valued based upon quoted prices for identical or similar instruments in markets that are not active, and model-based valuation techniques for which all significant assumptions are observable in the market.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(2) The fair value of the Convertible Note receivable from Viking at&#160;December&#160;31, 2017&#160;approximated the book value since the contractual maturity date was within five months from the end of 2017, and there was no plan to extend the maturity date. The fair value at</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">&#160;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017 was determined using a probability weighted option pricing model. The fair value is subjective and is affected by certain significant input to the valuation model such as the estimated volatility of the common stock, which was estimated to be 75% at December&#160;31, 2017. Changes in these assumptions may materially affect the fair value estimate. For the years ended December&#160;31, 2018</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">, </span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">December&#160;31, 2017, and December&#160;31, 2016, we reported an increase in the fair value of 0.0 million, an increase in the fair value of&#160;$0.9 million, and a decrease in the fair value of $0.2 million, respectively in "Other, net" of the consolidated statement of operations.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;&#160;&#160;</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(3) Investment in warrants, which we received as a result of Viking&#8217;s partial repayment of the Viking note receivable and our purchase of Viking common stock and warrants in April 2016, is classified as level 1 as the fair value is determined using quoted market prices in active markets for the same securities.&#160;See further discussion in &#8220;</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-style:italic;line-height:120%;">Note (2), Investment in Viking.</span><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">&#8221;  </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(4) The fair value of Crystal contingent liabilities was determined using a probability weighted income approach. Most of the contingent payments are based on development or regulatory milestones as defined in the merger agreement with Crystal. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates regarding the timing and probability of achievement of certain developmental and regulatory milestones. At </span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;"> December&#160;31, 2018, most of the development and regulatory milestones were estimated to be highly probable of being achieved in 2019. Changes in these estimates may materially affect the fair value. </span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(5) The fair value of CyDex contingent liabilities was determined based on the income approach. To the extent the estimated future income may vary significantly given the long-term nature of the estimate, we utilize a Monte Carlo model. The fair value is subjective and is affected by changes in inputs to the valuation model including management&#8217;s estimates of timing and probability of achievement of certain revenue thresholds and developmental and regulatory milestones&#160;which may be achieved and affect amounts owed to former license holders.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(6) In connection with our acquisition of Metabasis in January 2010, we issued Metabasis stockholders four tradable CVRs, one CVR from each of four respective series of CVR, for each Metabasis share. The CVRs entitle Metabasis stockholders to cash payments as frequently as every six months as cash is received by us from proceeds from the sale or partnering of any of the Metabasis drug development programs, among other triggering events. The liability for the CVRs is determined using quoted prices in a market that is not active for the underlying CVR. The carrying amount of the liability may fluctuate significantly based upon quoted market prices and actual amounts paid under the agreements may be materially different than the carrying amount of the liability. Several of the Metabasis drug development programs have been outlicensed to Viking, including VK2809. VK2809 is a novel selective TR-&#946; agonist with potential in multiple indications, including hypercholesterolemia, dyslipidemia, NASH, and X-ALD. Under the terms of the agreement with Viking, we may be entitled to up to $375.0 million of development, regulatory and commercial milestones and tiered royalties on potential future sales including a&#160;$10.0 million payment upon initiation of a Phase 3 clinical trial. Another Metabasis drug development program, RVT-1502, has been outlicensed to Metavant. RVT-1502 is a novel, orally-bioavailable, small molecule, glucagon receptor antagonist or &#8220;GRA.&#8221; We may be entitled to up to $529.0 million in milestone payments and royalties.</span></div><div><span><br/></span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;line-height:120%;">(7) The liability for amounts owed to a former licensor is determined using quoted market prices in active markets for the underlying investment received from a partner, a portion of which is owed to a former licensor.</span></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock', window );">Schedule of Reconciliation of Level 3 Financial Instruments</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the level 3 financial instruments as of December&#160;31, 2018 is as follows (in thousands):</span></div><div style="text-indent:45pt;"><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:81.284457%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:14.715543%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,877&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-weight:400;line-height:100%;">Cash payment received as repayment of note receivable</span></div><div><span><br/></span></div></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,877)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instrument assets as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Liabilities</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December 31, 2017</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,990&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments to CVR holders and other contingency payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,025)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value adjustments to contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,974)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of level 3 financial instruments as of December&#160;31, 2018</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,991&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19279-110258<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2C<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=SL7498348-110258<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19190-110258<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (bb)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueDisclosuresAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueDisclosuresAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>38
<FILENAME>R23.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817459168">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Lease Obligations (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesAbstract', window );"><strong>Leases [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock', window );">Schedule of Operating Lease Obligations and Payments Expected to be Received from Sublease Agreements</a></td>
<td class="text">The following table provides a summary of operating lease obligations and payments expected to be received from sublease agreements as of December&#160;31, 2018 (in thousands):<table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.005848%;"><tr><td style="width:1.0%;"/><td style="width:39.679627%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.577605%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.975117%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.577605%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.975117%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.044168%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:7.797823%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:1.044168%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.108865%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.733126%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:7.486781%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Operating lease obligations:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Lease</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Termination</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Date</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Less than 1</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">year</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1-2 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3-4 years</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Corporate headquarters - San Diego, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2023</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">135&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">283&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">616&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">373&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">373&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Bioscience and Technology Business Center - Lawrence, KS</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 2020</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">57&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">113&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Emeryville, CA</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">260&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">455&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">715&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Emeryville, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">August 2021</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">203&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">351&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">554&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office - Winnersh, United Kingdom</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">April 2019</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research Facility  - Cambridge, United Kingdom</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">September 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">549&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">549&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,620&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,963&#160;</span></td></tr><tr><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:8pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Sublease payments expected to be received:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Office and research facility - La Jolla, CA</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">June 2019</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">360&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">360&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating lease obligations</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,260&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,145&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">198&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,603&#160;</span></td></tr></table><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeasesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeasesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of lessor's property under leasing agreements and property available for lease (not currently under lease) by property class, the gross amount, accumulated depreciation and net amount of  as of the balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 20<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84164653&amp;loc=d3e41551-112718<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>39
<FILENAME>R24.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6603446736">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Convertible Senior Notes (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtDisclosureAbstract', window );"><strong>Debt Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfDebtTableTextBlock', window );">Schedule of Equity and Liability Components of the Convertible Senior Notes</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes information about the equity and liability components of the 2019 Notes and 2023 Notes (in thousands).</span></div><div style="text-align:center;margin-top:9pt;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:57.970674%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:16.768328%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:2.292669%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:16.768328%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2019 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,326&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">245,000&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(893)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(20,471)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total current portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,433&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">224,529&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Principle amount of 2023 Notes outstanding</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">750,000&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Unamortized discount (including unamortized debt issuance cost)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(140,136)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total long-term portion of notes payable</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">609,864&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Carrying value of equity component of 2023 Notes</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">127,997&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair value of convertible senior notes outstanding (Level 2)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">713,533&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">446,360&#160;</span></td></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfDebtTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of information pertaining to short-term and long-debt instruments or arrangements, including but not limited to identification of terms, features, collateral requirements and other information necessary to a fair presentation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfDebtTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>40
<FILENAME>R25.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817314080">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Balance Sheet Account Details (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OtherBalanceSheetDetailsAbstract', window );"><strong>Other Balance Sheet Details [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock', window );">Schedule of Investment Categories</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes the various investment categories at December&#160;31, 2018 and 2017 (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"/><td style="width:41.088235%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.676471%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cost</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">gains</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Gross unrealized</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">losses</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Estimated</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">fair value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">311,066&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(29)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">311,063&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53,223&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(45)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53,179&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">135&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,191&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,326&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">225,731&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(76)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">225,663&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,982&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(9)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,973&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,017&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,013&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">600,154&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,226&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(163)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">601,217&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Short-term investments</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Bank deposits</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">80,095&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(42)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">80,059&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55,335&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(96)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55,239&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Corporate equity securities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">207&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1689&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,896&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Commercial paper</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,933&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(20)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,913&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Agency bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,991&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,990&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     U.S. Government bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,939&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,929&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Municipal bonds</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,028&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(13)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,015&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">179,528&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,695&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(182)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">181,041&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock', window );">Schedule of Other Current Assets</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Other current assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restricted cash</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking warrants</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">9,257&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,545&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,514&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,418&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,514&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentTextBlock', window );">Schedule of Property and Equipment</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Property and equipment is stated at cost and consists of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Lab and office equipment</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,183&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,460&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Leasehold improvements</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,418&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,917&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Computer equipment and software</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">936&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">697&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,537&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,074&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Less accumulated depreciation and amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,165)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,862)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,372&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,212&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock', window );">Schedule of Goodwill and Other Identifiable Intangible Assets</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Goodwill and identifiable intangible assets consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:12pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="9" style="padding-top:2px;padding-bottom:2px;height:12pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Indefinite lived intangible assets</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     IPR&amp;D</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,923&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Goodwill</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">86,646&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">85,959&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Definite lived intangible assets</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Complete technology</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">235,413&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">222,900&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(35,070)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(23,301)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Trade name</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,642&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,642&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,048)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(916)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Customer relationships</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,600&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,600&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">          Less: Accumulated amortization</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(11,744)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,264)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total goodwill and other identifiable intangible assets, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">306,439&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">314,543&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock', window );">Schedule of Accrued Liabilities</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;font-style:italic;font-weight:700;line-height:120%;">Accrued liabilities consist of the following (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:72.008811%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Compensation</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,045&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,085&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Legal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">942&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">430&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Amounts owed to former licensees</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">428&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">396&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Royalties owed to third parties</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,025&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">954&#160;</span></td></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments due to broker for share repurchases</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,613&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Return reserve</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,590&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Restructuring</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,093&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,464&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,512&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,200&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7,377&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ScheduleofContingentLiabilitiesTableTextBlock', window );">Schedule of Contingent Liabilities</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes contingent liabilities&#160;as of December 2018 and 2017 (in thousands):</span></div><div><span><br/></span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:94.736842%;"><tr><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.265432%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:7.876543%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/><td colspan="3" style="display:none;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:7.413580%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.419753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.728395%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2016</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Additions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Payments</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fair Value Adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31, 2018</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Cydex</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,600&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(5,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,600&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(25)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,050)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">525&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Metabasis</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,500&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,500&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4,000&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,900)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,500&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Crystal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(924)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,476&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total </span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,100&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(5,000)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,500&#160;</span></td><td colspan="3" style="display:none;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,400&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,000&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,925)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,426&#160;</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,501&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OtherBalanceSheetDetailsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Other Balance Sheet Details [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OtherBalanceSheetDetailsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ScheduleofContingentLiabilitiesTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Schedule of Contingent Liabilities [Table Text Block]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ScheduleofContingentLiabilitiesTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -URI http://asc.fasb.org/topic&amp;trid=2196928<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(13))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the components of accrued liabilities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of goodwill and intangible assets, which may be broken down by segment or major class.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=108376223&amp;loc=d3e13816-109267<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the carrying amounts of other current assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>41
<FILENAME>R26.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817929728">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquityAbstract', window );"><strong>Equity [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock', window );">Schedule of Accounting for Share-Based Compensation</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following table summarizes share-based compensation expense (in thousands):</span></div><div style="text-align:center;margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.707602%;"><tr><td style="width:1.0%;"/><td style="width:63.102639%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.533138%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.143695%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation expense as a component of:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development expenses</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,352&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,235&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,836&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">General and administrative expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,494&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,680&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,057&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,846&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,915&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">18,893&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock', window );">Schedule of Stock Option Plan Activity</a></td>
<td class="text"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a summary of our stock option plan activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:48.220913%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.076583%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.340206%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Exercise</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Remaining</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Contractual</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Term in</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Aggregate</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Intrinsic</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">(In&#160; thousands)</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,876,332&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">53.17&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.77</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">157,340&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">228,362&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">162.00&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercised</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(358,162)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">55.24&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,228)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">114.53&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at December 31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,736,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125,858&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Exercisable at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,313,374&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47.03&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.56</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">117,314&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Options vested and expected to vest as of December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,734,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125,858&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock', window );">Schedule of Stock Option Plan Activity by Exercise Price Range</a></td>
<td class="text"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">Following is a further breakdown of the options outstanding as of December&#160;31, 2018:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.830409%;"><tr><td style="width:1.0%;"/><td style="width:25.366864%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.391716%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.313609%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.539645%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:14.568047%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Range of exercise prices</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">outstanding</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">remaining&#160; life</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">in&#160;years</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise price</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Options</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercisable</span></div></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted&#160;average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">exercise&#160;price</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$8.58 - $10.05</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">184,702&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.87</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.00&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">184,702&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10.00&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$10.12 - $12.81</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,510&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.92</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.40&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,510&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11.40&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$14.47 - $14.47</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">217,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.11</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14.47&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">203,616&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14.47&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$16.14 - $17.88</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,790&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.17</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16.36&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,790&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16.36&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$21.92 - $21.92</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">200,372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">4.13</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21.92&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">200,372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21.92&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$32.00 - $56.26</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">182,767&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.70</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50.38&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">174,470&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50.10&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$63.58 - $67.53</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,434&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.44</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67.42&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,153&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67.47&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$74.42 - $74.42</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">190,825&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.12</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">74.42&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">190,825&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">74.42&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$85.79 - $100.38</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">299,282&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">7.57</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">93.32&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">157,872&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">91.62&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$101.15 - $195.91</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">353,006&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8.79</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">148.50&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">96,064&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">131.77&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,734,304&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.47</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">66.71&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,313,374&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">47.03&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock', window );">Schedule of Stock Option Weighted-Average Assumptions</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The assumptions used for the specified reporting periods and the resulting estimates of weighted-average grant date fair value per share of options granted:</span></div><div><span><br/></span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.538012%;"><tr><td style="width:1.0%;"/><td style="width:51.709199%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.986944%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.541840%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:12.540059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.541840%;"/><td style="width:0.1%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="18" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Risk-free interest rate</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.7%-3.0%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.0%-2.2%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.3%-1.9%</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected volatility</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33%-36%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">43%-47%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">48%-50%</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expected term</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5.1 to 5.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.5 to 6.8 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6.6 to 6.7 years</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock', window );">Schedule of Restricted Stock Activity</a></td>
<td class="text"><div style="margin-top:5pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following is a summary of our restricted stock activity and related information:</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.561404%;"><tr><td style="width:1.0%;"/><td style="width:71.127753%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.628488%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.534214%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:11.509545%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Shares</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Weighted-Average</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Grant&#160;Date Fair</span></div><div style="text-align:center;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:8pt;font-weight:700;line-height:100%;">Value</span></div></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2017</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">133,294&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">91.60&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Granted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">62,133&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">169.92&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Vested</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(61,989)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">86.19&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Forfeited</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,165)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">125.16&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Outstanding at December&#160;31, 2018</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">132,273&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">130.63&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Schedule for share based compensation expense for awards to employees and directors.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquityAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquityAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the changes in outstanding nonvested restricted stock units.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (f)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>42
<FILENAME>R27.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817450960">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxDisclosureAbstract', window );"><strong>Income Tax Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock', window );">Schedule of Components of Income Tax Benefit</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The components of the income tax expense (benefit) for continuing operations are as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:98.976608%;"><tr><td style="width:1.0%;"/><td style="width:65.503693%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.833973%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.686263%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.192024%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Current expense (benefit):</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">424&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">111&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(158)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">261&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">266&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">372&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred expense (benefit):</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Federal</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,928&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,075&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,534&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(185)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">228&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(240)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Foreign</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,009&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,675&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,327&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock', window );">Schedule of Effective Income Tax Rate Reconciliation</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of income tax expense (benefit) from continuing operations to the amount computed by applying the statutory federal income tax rate to the net income (loss) from continuing operations is summarized as follows (in thousands):</span></div><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:9pt;line-height:120%;">&#160;</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.415205%;"><tr><td style="width:1.0%;"/><td style="width:65.941176%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.535294%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.682353%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.147059%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="15" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Year Ended December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Tax at federal statutory rate</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,400&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,031&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,786&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">State, net of federal benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,635&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">622&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">175&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Contingent liabilities</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">948&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">903&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,225&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Share-based compensation</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(8,131)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,019)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">263&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research and development credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,758)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,821)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,525)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in uncertain tax positions</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">858&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,308&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,423&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Rate change for changes in federal or state law</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">178&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">32,429&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">25&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in valuation allowance</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,225)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,169)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,283&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Expired NOLs and credits</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3,054&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Change in derivatives</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">615&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,435&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">391&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(328)</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,009&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">44,675&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">10,327&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock', window );">Schedule of Deferred Tax Assets and Liabilities</a></td>
<td class="text">Significant components of our deferred tax assets and liabilities as of December&#160;31, 2018 and 2017 are shown below. We assess the positive and negative evidence to determine if sufficient future taxable income will be generated to use the existing deferred tax assets. Our evaluation of evidence resulted in management concluding that the majority of our&#160;deferred tax assets will be realized.  However, we maintain a valuation allowance to offset certain net deferred tax assets as management believes realization of such assets are uncertain as of December&#160;31, 2018, 2017 and 2016. The valuation allowance decreased $2.5 million in 2018, decreased $8.4 million in 2017 and increased $6.3 million in 2016.<table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.175439%;"><tr><td style="width:1.0%;"/><td style="width:74.958525%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:9.059908%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.568049%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:9.213518%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December&#160;31,</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="9" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(in thousands)</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax assets:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net operating loss carryforwards</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">57,181&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">90,272&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Research credit carryforwards</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">31,101&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,677&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fixed assets and intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,637&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,984&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Accrued expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">657&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">845&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred revenue</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">957&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">17&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Capital Loss Carryforward</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,609&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,137&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Other</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">11,430&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">12,499&#160;</span></td></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">102,963&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">143,040&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Valuation allowance for deferred tax assets</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(4,476)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(6,987)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax assets</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">98,487&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">136,053&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred tax liabilities:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Retrophin fair value adjustment</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(179)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(243)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Convertible debt</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,905)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(737)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(44,643)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(48,237)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Identified indefinite lived intangibles</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,759)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,414)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Investment in Viking</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,480)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#8212;&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net deferred tax liabilities</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(51,966)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(51,631)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Deferred income taxes, net</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">46,521&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">84,422&#160;</span></td></tr></table><span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock', window );">Schedule of Unrecognized Tax Benefits</a></td>
<td class="text"><div style="margin-top:9pt;"><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">A reconciliation of the amount of unrecognized tax benefits at December&#160;31, 2018, 2017 and 2016 is as follows (in thousands):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:95.029240%;"><tr><td style="width:1.0%;"/><td style="width:64.769231%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:8.461538%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.569231%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.461538%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.569231%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:8.769231%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="height:15pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="15" style="padding-top:2px;padding-bottom:2px;height:15pt;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">December 31,&#160;</span></td><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2016</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at beginning of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,363&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,770&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">36,452&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions based on tax positions related to the current year</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,247&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1,067&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">70&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Additions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">336&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">109&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2,408&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Reductions for tax positions of prior years</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(657)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,583)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(160)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Balance at end of year</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">30,289&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,363&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;border-bottom:3pt double #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">38,770&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of the change in unrecognized tax benefits, excluding amounts pertaining to examined tax returns.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>43
<FILENAME>R28.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6889511360">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Summary of Unaudited Quarterly Financial Information (Tables)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th"><div>Dec. 31, 2018</div></th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract', window );"><strong>Quarterly Financial Information Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock', window );">Schedule of Quarterly Financial Information</a></td>
<td class="text"><div><span style="background-color:rgb(255,255,255, 0.0);color:#000000;font-family:Times New Roman;font-size:10pt;line-height:120%;">The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results and cash flows of interim periods. Summarized quarterly data for 2018 and 2017 are as follows (in thousands, except per share amounts):</span></div><div style="margin-bottom:6pt;"><table style="margin-left:auto;margin-right:auto;border-collapse:collapse;text-align:left;text-indent:0pt;display:inline-table;width:99.269006%;"><tr><td style="width:1.0%;"/><td style="width:45.128130%;"/><td style="width:1.0%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/><td style="width:0.1%;"/><td style="width:0.536377%;"/><td style="width:0.1%;"/><td style="width:1.0%;"/><td style="width:10.665685%;"/><td style="width:1.0%;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">&#160;</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">First Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Second Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);"> Third Quarter</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:center;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:8pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Fourth Quarter</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2018</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">56,157&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">90,043&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">45,663&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">59,590&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,116&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,868&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,301&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">26,441&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax (expense) benefit</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(10,033)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(22,419)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(11,864)</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,307&#160;</span></td></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/><td colspan="3" style="display:none;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">45,279&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">73,160&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">67,362&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Arial;color:#000000;background-color:rgb(255,255,255, 0.0);"/></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(42,482)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.13&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.45&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">3.19&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2.02)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">     Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">1.83&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.99&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2.80&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2.02)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,209&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,212&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,148&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,800&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,438&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">24,052&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:3pt double #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:700;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">2017</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total revenues</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">29,267&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">27,995&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">33,375&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">50,465&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Total operating costs and expenses</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">19,051&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">14,980&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">16,882&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">22,113&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Income tax expense</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(1,114)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(2,242)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(3,645)</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(37,674)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">5,079&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">6,058&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">8,426&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(7,007)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Basic per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.24&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.29&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.40&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.33)</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Diluted per share amounts:</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Net income (loss)</span></td><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.22&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.26&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">0.36&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">$</span></td><td colspan="2" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;border-top:1pt solid #000000;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">(0.33)</span></td></tr><tr><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="height:13pt;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;border-top:1pt solid #000000;padding-left:1pt;padding-right:1pt;"/></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;basic</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">20,938&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,013&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,071&#160;</span></td><td colspan="3" style="background-color:#cceeff;text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:#cceeff;text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,109&#160;</span></td></tr><tr><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:top;padding-left:12pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">Weighted average shares&#8212;diluted</span></td><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,019&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,216&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">23,551&#160;</span></td><td colspan="3" style="background-color:rgb(255,255,255, 0.0);text-align:left;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"/><td colspan="3" style="padding-top:2px;padding-bottom:2px;background-color:rgb(255,255,255, 0.0);text-align:right;vertical-align:bottom;padding-left:1pt;padding-right:1pt;"><span style="font-size:10pt;font-weight:400;font-family:Times New Roman;color:#000000;background-color:rgb(255,255,255, 0.0);">21,109&#160;</span></td></tr></table></div><span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_QuarterlyFinancialInformationDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 270<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=109225645&amp;loc=d3e1280-108306<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>nonnum:textBlockItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>44
<FILENAME>R29.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6914852848">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)<br></strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="7">12 Months Ended</th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
</tr>
<tr>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Sep. 30, 2018 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Jun. 30, 2018 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Mar. 31, 2018 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Dec. 31, 2017 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Sep. 30, 2017 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Jun. 30, 2017 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Mar. 31, 2017 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th" colspan="2">
<div>Dec. 31, 2018 </div>
<div>USD ($) </div>
<div>trading_day </div>
<div>$ / shares</div>
</th>
<th class="th" colspan="2">
<div>Dec. 31, 2017 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th" colspan="2">
<div>Dec. 31, 2016 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Dec. 31, 2007 </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Jan. 01, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Oct. 06, 2017 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Jan. 01, 2017 </div>
<div>USD ($)</div>
</th>
<th class="th"><div>May 03, 2016</div></th>
<th class="th">
<div>Jan. 31, 2010 </div>
<div>right</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrealizedGainLossOnInvestments', window );">Unrealized gain on AFS investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 48,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 144,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">$ (1,109,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum', window );">Maturity period of cash and cash equivalents, maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">3 months<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InventoryWriteDown', window );">Write-downs related to obsolete inventory</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RetainedEarningsAccumulatedDeficit', window );">Retained earnings (accumulated deficit)</a></td>
<td class="num">$ (229,197,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (400,924,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(229,197,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(400,924,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived', window );">Milestone payment received</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">4,600,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived', window );">Third-party portion of milestone payment received</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ContractWithCustomerLiabilityRevenueRecognized', window );">Revenue recognized</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,600,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="nump">50,465,000<span></span>
</td>
<td class="nump">$ 33,375,000<span></span>
</td>
<td class="nump">$ 27,995,000<span></span>
</td>
<td class="nump">$ 29,267,000<span></span>
</td>
<td class="nump">59,590,000<span></span>
</td>
<td class="nump">$ 45,663,000<span></span>
</td>
<td class="nump">$ 90,043,000<span></span>
</td>
<td class="nump">$ 56,157,000<span></span>
</td>
<td class="nump">251,453,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">141,102,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">108,973,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="num">$ (7,007,000)<span></span>
</td>
<td class="nump">$ 8,426,000<span></span>
</td>
<td class="nump">$ 6,058,000<span></span>
</td>
<td class="nump">$ 5,079,000<span></span>
</td>
<td class="num">$ (42,482,000)<span></span>
</td>
<td class="nump">$ 67,362,000<span></span>
</td>
<td class="nump">$ 73,160,000<span></span>
</td>
<td class="nump">$ 45,279,000<span></span>
</td>
<td class="nump">$ 143,321,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 12,556,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">$ (1,636,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareDiluted', window );">Earnings per share - diluted (USD per share) | $ / shares</a></td>
<td class="num">$ (0.33)<span></span>
</td>
<td class="nump">$ 0.36<span></span>
</td>
<td class="nump">$ 0.26<span></span>
</td>
<td class="nump">$ 0.22<span></span>
</td>
<td class="num">$ (2.02)<span></span>
</td>
<td class="nump">$ 2.80<span></span>
</td>
<td class="nump">$ 2.99<span></span>
</td>
<td class="nump">$ 1.83<span></span>
</td>
<td class="nump">$ 5.96<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">$ 0.53<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="num">$ (0.08)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CommonStockDividendsPerShareDeclared', window );">Dividend declared (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 2.50<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_GainLossOnSaleOfBusiness', window );">Gain on disposition of product line</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 1,100,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation', window );">Provision for taxes on gain from discontinued operations</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">408,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Equity component of currently redeemable convertible notes (Note 6)</a></td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 18,859,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">18,859,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivities', window );">Net cash used in investing activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(423,269,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(79,179,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(134,415,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInOperatingActivities', window );">Net cash provided by operating activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">194,059,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">88,570,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">60,733,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInFinancingActivities', window );">Net cash provided by financing activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 328,585,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(7,523,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(4,994,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember', window );">Stock Options | 2002 Stock Incentive Plan</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod', window );">Award expiration period</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">10 years<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember', window );">Stock Options | Vest 1/8 on the six month anniversary of the date of grant | 2002 Stock Incentive Plan</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1', window );">Award vesting period</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">6 months<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage', window );">Award vesting right (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">12.50%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember', window );">Stock Options | Vest 1/48 each month for forty-two months | 2002 Stock Incentive Plan</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1', window );">Award vesting period</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">42 months<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage', window );">Award vesting right (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2.08%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MinimumMember', window );">Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentUsefulLife', window );">Property and equipment, useful life</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">3 years<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MaximumMember', window );">Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentUsefulLife', window );">Property and equipment, useful life</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">10 years<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned', window );">Value of share consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 10,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember', window );">Metabasis Therapeutics</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_NumberOfContingentValueRightsIssued', window );">Number of contingent value rights | right</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">4<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_RoyaltyAgreementsMember', window );">Royalty Agreements</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ProductRoyaltyPercentage', window );">Product royalty (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember', window );">Palvella | Royalty Agreements</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones', window );">Additional royalties receivable under sales-based milestones</a></td>
<td class="nump">$ 8,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 8,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember', window );">Palvella | Royalty Agreements | Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ProductRoyaltyPercentage', window );">Product royalty (as a percent)</a></td>
<td class="nump">5.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5.00%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember', window );">Palvella | Royalty Agreements | Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ProductRoyaltyPercentage', window );">Product royalty (as a percent)</a></td>
<td class="nump">9.80%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">9.80%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_CounterpartyNameAxis=lgnd_AziyoMember', window );">Aziyo | Royalty Agreements</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromRoyaltiesReceived', window );">Proceeds from royalties received</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">10,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ProductRoyaltyPercentage', window );">Product royalty (as a percent)</a></td>
<td class="nump">5.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5.00%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones', window );">Additional royalties receivable under sales-based milestones</a></td>
<td class="nump">$ 10,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 10,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent', window );">Effective interest rate of forecasted cash flows (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">26.00%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_CounterpartyNameAxis=lgnd_CorMatrixMember', window );">CorMatrix | Royalty Agreements</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ProductRoyaltyPercentage', window );">Product royalty (as a percent)</a></td>
<td class="nump">5.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5.00%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RoyaltyAgreementExpirationPeriod', window );">Expiration period of royalty agreement</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">10 years<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member', window );">2023 Convertible Senior Notes | Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentFaceAmount', window );">Principal amount outstanding</a></td>
<td class="nump">$ 750,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 750,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentInterestRateStatedPercentage', window );">Interest on debt instrument (as a percent)</a></td>
<td class="nump">0.75%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.75%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member', window );">2019 Convertible Senior Notes | Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal', window );">Threshold business days for repayment of principal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">3 days<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1', window );">Number of consecutive trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">50<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member', window );">Accounting Standards Update 2016-09</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 18,103,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201409Member', window );">Accounting Standards Update 2014-09</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 25,581,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member', window );">Accounting Standards Update 2016-01</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201615Member', window );">Accounting Standards Update 2016-15</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInInvestingActivities', window );">Net cash used in investing activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(5,000,000.0)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(8,800,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInOperatingActivities', window );">Net cash provided by operating activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">5,000,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">2,300,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetCashProvidedByUsedInFinancingActivities', window );">Net cash provided by financing activities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">6,500,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementEquityComponentsAxis=us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember', window );">AOCI Including Portion Attributable to Noncontrolling Interest | Accounting Standards Update 2016-01</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(2,700,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember', window );">Retained Earnings</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net income (loss)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 143,321,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">12,556,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(1,636,000)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember', window );">Retained Earnings | Accounting Standards Update 2016-09</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 17,647,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember', window );">Retained Earnings | Accounting Standards Update 2014-09</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">25,581,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember', window );">Retained Earnings | Accounting Standards Update 2016-01</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative-effect adjustment from adoption of ASU</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,662,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis=us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member', window );">Difference between Revenue Guidance in Effect before and after Topic 606 | Accounting Standards Update 2014-09</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RetainedEarningsAccumulatedDeficit', window );">Retained earnings (accumulated deficit)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (25,600,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputExpectedDividendRateMember', window );">Dividend yield</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationAbstract', window );"><strong>Share-based Compensation</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquitySecuritiesFvNiMeasurementInput', window );">Measurement input</a></td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_LegalEntityAxis=lgnd_PalvellaTherapeuticsIncMember', window );">Palvella | Director</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OwnershipInEntityByDirectorPercentage', window );">Ownership in entity by director (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2.00%<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=us-gaap_RoyaltyMember', window );">Royalties</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 128,556,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">88,685,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">59,423,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=us-gaap_RoyaltyMember', window );">Royalties | Calculated under Revenue Guidance in Effect before Topic 606</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">121,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">88,700,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">59,400,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyPromactaMember', window );">Royalty, Promacta</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">99,300,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyPromactaMember', window );">Royalty, Promacta | Calculated under Revenue Guidance in Effect before Topic 606</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">92,300,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">62,900,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">43,000,000.0<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyKyprolisMember', window );">Royalty, Kyprolis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">21,700,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyKyprolisMember', window );">Royalty, Kyprolis | Calculated under Revenue Guidance in Effect before Topic 606</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20,900,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">16,400,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">12,100,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyEvomelaMember', window );">Royalty, Evomela</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5,700,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyEvomelaMember', window );">Royalty, Evomela | Calculated under Revenue Guidance in Effect before Topic 606</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5,700,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">7,200,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">1,400,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyOtherMember', window );">Royalty, Other</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,900,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_RoyaltyOtherMember', window );">Royalty, Other | Calculated under Revenue Guidance in Effect before Topic 606</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BasisOfPresentationLineItems', window );"><strong>Basis of Presentation [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 2,100,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 2,200,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 2,900,000<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr><td colspan="21"></td></tr>
<tr><td colspan="21"><table class="outerFootnotes" width="100%"><tr class="outerFootnote">
<td style="vertical-align: top; width: 12pt;" valign="top">[1]</td>
<td style="vertical-align: top;" valign="top">The sum of net income per share amounts may not equal the total due to rounding</td>
</tr></table></td></tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Additional Royalties Receivable Under Sales-based Milestones</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BasisOfPresentationLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Basis of presentation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BasisOfPresentationLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ForecastedCashFlowsEffectiveInterestRatePercent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Forecasted Cash Flows, Effective Interest Rate, Percent</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ForecastedCashFlowsEffectiveInterestRatePercent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Maturity period of highly liquid securities maximum.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_NumberOfContingentValueRightsIssued">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of Contingent Value Rights Issued</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_NumberOfContingentValueRightsIssued</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:integerItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OwnershipInEntityByDirectorPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Ownership in Entity by Director, Percentage</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OwnershipInEntityByDirectorPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ProductRoyaltyPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Product Royalty Percentage</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ProductRoyaltyPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Revenue Recognition, Milestone Method Milestone Payment Received</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Revenue Recognition, Milestone Method Third-Party Portion of Milestone Payment Received</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RoyaltyAgreementExpirationPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Royalty Agreement, Expiration Period</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RoyaltyAgreementExpirationPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ThresholdBusinessDaysforRepaymentofPrincipal">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold Business Days for Repayment of Principal</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ThresholdBusinessDaysforRepaymentofPrincipal</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of equity interests (such as common shares, preferred shares, or partnership interest) issued or issuable to acquire the entity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(4)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CommonStockDividendsPerShareDeclared">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Aggregate dividends declared during the period for each share of common stock outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CommonStockDividendsPerShareDeclared</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ContractWithCustomerLiabilityRevenueRecognized">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130549-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ContractWithCustomerLiabilityRevenueRecognized</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of increase (decrease) to equity or (increase) decrease to net assets, resulting from the cumulative effect adjustment of a new accounting principle applied in the period of adoption.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The carrying amount of the equity component of convertible debt which may be settled in cash upon conversion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031897-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold period of specified consecutive trading days within which common stock price to conversion price of convertible debt instrument must exceed threshold percentage for specified number of trading days to trigger conversion feature.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:integerItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentFaceAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Face (par) amount of debt instrument at time of issuance.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28551-108399<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 55<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=114775985&amp;loc=d3e28878-108400<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentFaceAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentInterestRateStatedPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Contractual interest rate for funds borrowed, under the debt agreement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22(a)(1))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentInterestRateStatedPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of tax expense (benefit) on gain (loss) not previously recognized resulting from the disposal of a discontinued operation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 45<br> -Paragraph 3B<br> -URI http://asc.fasb.org/extlink&amp;oid=109222160&amp;loc=SL51721525-107759<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5C<br> -Subparagraph (b)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=SL51721675-107760<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 10<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32672-109319<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 205<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109222650&amp;loc=d3e1361-107760<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareDiluted">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 55<br> -Paragraph 52<br> -URI http://asc.fasb.org/extlink&amp;oid=109256448&amp;loc=d3e4984-109258<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 250<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=109234566&amp;loc=d3e22694-107794<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareDiluted</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquitySecuritiesFvNiMeasurementInput">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of input used to measure investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (bbb)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquitySecuritiesFvNiMeasurementInput</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:decimalItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_GainLossOnSaleOfBusiness">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of gain (loss) from sale and disposal of integrated set of activities and assets capable of being conducted and managed for purpose of providing return in form of dividend, lower cost, or other economic benefit to investor, owner, member and participant.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109239629&amp;loc=SL4582445-111684<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_GainLossOnSaleOfBusiness</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InventoryWriteDown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of loss from reductions in inventory due to subsequent measurement adjustments, including, but not limited to, physical deterioration, obsolescence, or changes in price levels.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 35<br> -Paragraph 1B<br> -URI http://asc.fasb.org/extlink&amp;oid=68049868&amp;loc=SL66093879-108312<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03.2)<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 35<br> -Paragraph 1C<br> -URI http://asc.fasb.org/extlink&amp;oid=68049868&amp;loc=SL66093883-108312<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 330<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=66092785&amp;loc=d3e4542-108314<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InventoryWriteDown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInFinancingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from financing activities, including discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInFinancingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInInvestingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from investing activities, including discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInInvestingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetCashProvidedByUsedInOperatingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 24<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3521-108585<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetCashProvidedByUsedInOperatingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(22))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(18))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromRoyaltiesReceived">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash received for royalties during the current period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 25<br> -Subparagraph (a),(c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3536-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromRoyaltiesReceived</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentUsefulLife">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentUsefulLife</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RetainedEarningsAccumulatedDeficit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cumulative amount of the reporting entity's undistributed earnings or deficit.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(30)(a)(3))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(23)(a)(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RetainedEarningsAccumulatedDeficit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130543-203045<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130539-203045<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130545-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Percentage of vesting of share-based compensation awards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrealizedGainLossOnInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrealizedGainLossOnInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PlanNameAxis=lgnd_TwoThousandTwoStockIncentivePlanMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PlanNameAxis=lgnd_TwoThousandTwoStockIncentivePlanMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VestingAxis=lgnd_VestingPeriodOneMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VestingAxis=lgnd_VestingPeriodOneMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VestingAxis=lgnd_VestingPeriodTwoMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VestingAxis=lgnd_VestingPeriodTwoMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MinimumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MinimumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MaximumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MaximumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_RoyaltyAgreementsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_RoyaltyAgreementsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_AziyoMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_AziyoMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_CorMatrixMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_CorMatrixMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongtermDebtTypeAxis=us-gaap_SeniorNotesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongtermDebtTypeAxis=us-gaap_SeniorNotesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201409Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201409Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201615Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201615Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementEquityComponentsAxis=us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementEquityComponentsAxis=us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementEquityComponentsAxis=us-gaap_RetainedEarningsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis=us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis=us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputExpectedDividendRateMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputExpectedDividendRateMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LegalEntityAxis=lgnd_PalvellaTherapeuticsIncMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LegalEntityAxis=lgnd_PalvellaTherapeuticsIncMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_TitleOfIndividualAxis=us-gaap_DirectorMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_TitleOfIndividualAxis=us-gaap_DirectorMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=us-gaap_RoyaltyMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=us-gaap_RoyaltyMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis=us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis=us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_RoyaltyPromactaMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_RoyaltyPromactaMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_RoyaltyKyprolisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_RoyaltyKyprolisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_RoyaltyEvomelaMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_RoyaltyEvomelaMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_RoyaltyOtherMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_RoyaltyOtherMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>45
<FILENAME>R30.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6914938272">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details) - Customer Concentration Risk - Revenue<br></strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskByTypeAxis=us-gaap_CustomerConcentrationRiskMember', window );">Partner A</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EntityWideRevenueMajorCustomerLineItems', window );"><strong>Revenue, Major Customer</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskPercentage1', window );">Total revenues (as a percent)</a></td>
<td class="nump">40.00%<span></span>
</td>
<td class="nump">46.00%<span></span>
</td>
<td class="nump">41.00%<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskByTypeAxis=us-gaap_CustomerConcentrationRiskMember', window );">Partner B</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EntityWideRevenueMajorCustomerLineItems', window );"><strong>Revenue, Major Customer</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskPercentage1', window );">Total revenues (as a percent)</a></td>
<td class="nump">13.00%<span></span>
</td>
<td class="nump">19.00%<span></span>
</td>
<td class="nump">14.00%<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskByTypeAxis=us-gaap_CustomerConcentrationRiskMember', window );">Partner C</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EntityWideRevenueMajorCustomerLineItems', window );"><strong>Revenue, Major Customer</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConcentrationRiskPercentage1', window );">Total revenues (as a percent)</a></td>
<td class="nump">20.00%<span></span>
</td>
<td class="nump">1000.00%<span></span>
</td>
<td class="nump">1000.00%<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConcentrationRiskPercentage1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 18<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6351-108592<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 50<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=109250915&amp;loc=d3e13531-108611<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 50<br> -Paragraph 21<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109250915&amp;loc=d3e13537-108611<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 275<br> -SubTopic 10<br> -Section 50<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=99393423&amp;loc=d3e6404-108592<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConcentrationRiskPercentage1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EntityWideRevenueMajorCustomerLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EntityWideRevenueMajorCustomerLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConcentrationRiskByTypeAxis=us-gaap_CustomerConcentrationRiskMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConcentrationRiskByTypeAxis=us-gaap_CustomerConcentrationRiskMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConcentrationRiskByBenchmarkAxis=us-gaap_SalesRevenueNetMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConcentrationRiskByBenchmarkAxis=us-gaap_SalesRevenueNetMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_MajorCustomersAxis=lgnd_PartnerAMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_MajorCustomersAxis=lgnd_PartnerAMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_MajorCustomersAxis=lgnd_PartnerBMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_MajorCustomersAxis=lgnd_PartnerBMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_MajorCustomersAxis=lgnd_PartnerCMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_MajorCustomersAxis=lgnd_PartnerCMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>46
<FILENAME>R31.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6886590816">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Sep. 30, 2018</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Sep. 30, 2017</div></th>
<th class="th"><div>Jun. 30, 2017</div></th>
<th class="th"><div>Mar. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="nump">$ 50,465<span></span>
</td>
<td class="nump">$ 33,375<span></span>
</td>
<td class="nump">$ 27,995<span></span>
</td>
<td class="nump">$ 29,267<span></span>
</td>
<td class="nump">$ 59,590<span></span>
</td>
<td class="nump">$ 45,663<span></span>
</td>
<td class="nump">$ 90,043<span></span>
</td>
<td class="nump">$ 56,157<span></span>
</td>
<td class="nump">$ 251,453<span></span>
</td>
<td class="nump">$ 141,102<span></span>
</td>
<td class="nump">$ 108,973<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember', window );">Material sales</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">29,123<span></span>
</td>
<td class="nump">22,070<span></span>
</td>
<td class="nump">22,502<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember', window );">License fees, milestones and other revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">93,774<span></span>
</td>
<td class="nump">30,347<span></span>
</td>
<td class="nump">27,048<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMember', window );">License fees</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">78,195<span></span>
</td>
<td class="nump">13,665<span></span>
</td>
<td class="nump">10,570<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_MilestoneMember', window );">Milestones</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">6,577<span></span>
</td>
<td class="nump">11,093<span></span>
</td>
<td class="nump">16,091<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesAndOtherProductOtherMember', window );">Other</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DisaggregationOfRevenueLineItems', window );"><strong>Disaggregation of Revenue [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 9,002<span></span>
</td>
<td class="nump">$ 5,589<span></span>
</td>
<td class="nump">$ 387<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DisaggregationOfRevenueLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DisaggregationOfRevenueLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130543-203045<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130539-203045<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130545-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_MaterialSalesCaptisolMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesandProductOtherMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_LicenseFeesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_MilestoneMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_MilestoneMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesAndOtherProductOtherMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_LicenseFeesMilestonesAndOtherProductOtherMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>47
<FILENAME>R32.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6885680896">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details) - Licensing Agreements - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">$ 36,298<span></span>
</td>
<td class="nump">$ 26,298<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization', window );">Less: accumulated amortization</a></td>
<td class="num">(4,838)<span></span>
</td>
<td class="num">(6,772)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsNet', window );">Total commercial license rights, net</a></td>
<td class="nump">31,460<span></span>
</td>
<td class="nump">19,526<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_LicensingAgreementsMember', window );">Aziyo &amp; CorMatrix</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">17,696<span></span>
</td>
<td class="nump">17,696<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_LicensingAgreementsMember', window );">Palvella</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">10,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_LicensingAgreementsMember', window );">Selexis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">$ 8,602<span></span>
</td>
<td class="nump">$ 8,602<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accumulated amount of amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 928<br> -SubTopic 340<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6473545&amp;loc=d3e61844-108004<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_LicensingAgreementsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_LicensingAgreementsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_AziyoandCorMatrixMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_AziyoandCorMatrixMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_PalvellaTherapeuticsIncMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_CounterpartyNameAxis=lgnd_SelexisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_CounterpartyNameAxis=lgnd_SelexisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>48
<FILENAME>R33.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6913056384">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)<br></strong></div></th>
<th class="th">
<div>Jun. 19, 2018 </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>May 22, 2018 </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>Aug. 31, 2014 </div>
<div>$ / shares</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharePrice', window );">Common stock price (USD per share)</a></td>
<td class="nump">$ 195.91<span></span>
</td>
<td class="nump">$ 187.09<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share)</a></td>
<td class="nump">248.48<span></span>
</td>
<td class="nump">248.48<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_invest_InvestmentWarrantsExercisePrice', window );">Exercise price, warrants (USD per share)</a></td>
<td class="nump">$ 315.38<span></span>
</td>
<td class="nump">$ 315.38<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Risk-free interest rate</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">0.028<span></span>
</td>
<td class="nump">0.029<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Volatility | Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">0.3<span></span>
</td>
<td class="nump">0.3<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Volatility | Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">0.35<span></span>
</td>
<td class="nump">0.35<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Dividend yield</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Annual coupon rate</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">0.0075<span></span>
</td>
<td class="nump">0.0075<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Remaining contractual term (in years)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="nump">4.98<span></span>
</td>
<td class="nump">5.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharePrice', window );">Common stock price (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 187.09<span></span>
</td>
<td class="nump">$ 135.70<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Risk-free interest rate</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.0247<span></span>
</td>
<td class="nump">0.0260<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Volatility | Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.3<span></span>
</td>
<td class="nump">0.3<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Volatility | Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.35<span></span>
</td>
<td class="nump">0.35<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Dividend yield</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Annual coupon rate</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.0075<span></span>
</td>
<td class="nump">0.0075<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Remaining contractual term (in years)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems', window );"><strong>Derivative Instruments and Hedging Activities Disclosures [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeLiabilityMeasurementInput', window );">Derivative liability, measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1.25<span></span>
</td>
<td class="nump">0.63<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_invest_InvestmentWarrantsExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Exercise price of the warrants.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation S-X (SX)<br> -Number 210<br> -Article 12<br> -Section 13<br> -Sentence Column A<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">invest_InvestmentWarrantsExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>invest_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ExercisePriceofConvertibleBondHedge">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Exercise Price of Convertible Bond Hedge</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ExercisePriceofConvertibleBondHedge</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeLiabilityMeasurementInput">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of input used to measure derivative liability.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (bbb)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeLiabilityMeasurementInput</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:decimalItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Price of a single share of a number of saleable stocks of a company.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputRiskFreeInterestRateMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputRiskFreeInterestRateMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputPriceVolatilityMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputPriceVolatilityMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MinimumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MinimumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MaximumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MaximumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputExpectedDividendRateMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputExpectedDividendRateMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=lgnd_MeasurementInputCouponRateMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=lgnd_MeasurementInputCouponRateMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=lgnd_MeasurementInputRemainingTermMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=lgnd_MeasurementInputRemainingTermMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>49
<FILENAME>R34.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6915072704">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details) - shares<br> shares in Thousands</strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Sep. 30, 2018</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Sep. 30, 2017</div></th>
<th class="th"><div>Jun. 30, 2017</div></th>
<th class="th"><div>Mar. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract', window );"><strong>Organization, Consolidation and Presentation of Financial Statements [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic', window );">Weighted-average common shares outstanding - basic (shares)</a></td>
<td class="nump">21,109<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">21,013<span></span>
</td>
<td class="nump">20,938<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">21,148<span></span>
</td>
<td class="nump">21,212<span></span>
</td>
<td class="nump">21,209<span></span>
</td>
<td class="nump">21,160<span></span>
</td>
<td class="nump">21,032<span></span>
</td>
<td class="nump">20,831<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareBasicAndDilutedAbstract', window );"><strong>Dilutive potential common shares:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfSharesRestrictedStock', window );">Restricted stock (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">72<span></span>
</td>
<td class="nump">141<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements', window );">Stock options (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,125<span></span>
</td>
<td class="nump">1,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants', window );">Warrants (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,017<span></span>
</td>
<td class="nump">94<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities', window );">2019 Convertible Senior Notes (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">693<span></span>
</td>
<td class="nump">1,214<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding', window );">Shares used to compute diluted income per share (shares)</a></td>
<td class="nump">21,109<span></span>
</td>
<td class="nump">23,551<span></span>
</td>
<td class="nump">23,216<span></span>
</td>
<td class="nump">23,019<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">24,052<span></span>
</td>
<td class="nump">24,438<span></span>
</td>
<td class="nump">24,800<span></span>
</td>
<td class="nump">24,067<span></span>
</td>
<td class="nump">23,481<span></span>
</td>
<td class="nump">20,831<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount', window );">Potentially dilutive shares excluded from calculation due to anti-dilutive effect (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,845<span></span>
</td>
<td class="nump">335<span></span>
</td>
<td class="nump">3,544<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareBasicAndDilutedAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareBasicAndDilutedAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of call options and warrants using the treasury stock method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of convertible debt securities using the if-converted method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 40<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1930-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of share based payment arrangements using the treasury stock method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28A<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1500-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 16<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1505-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1448-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfSharesOutstandingBasic</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfSharesRestrictedStock">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares of restricted stock determined by relating the portion of time within a reporting period that restricted shares have been outstanding to the total time in that period. Restricted shares are subject to sales, contractual, regulatory or other restrictions that prevent or inhibit the holder from freely disposing of them before the restriction ends.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e2646-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfSharesRestrictedStock</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>50
<FILENAME>R35.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6813130480">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Investment in Viking - Narrative (Details) - USD ($)<br> $ / shares in Units, $ in Thousands</strong></div></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1">1 Months Ended</th>
<th class="th" colspan="1">3 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
</tr>
<tr>
<th class="th"><div>May 23, 2018</div></th>
<th class="th"><div>Apr. 13, 2016</div></th>
<th class="th"><div>May 31, 2014</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
<th class="th"><div>Jul. 15, 2017</div></th>
<th class="th"><div>Apr. 30, 2016</div></th>
<th class="th"><div>Jan. 31, 2016</div></th>
<th class="th"><div>Aug. 31, 2014</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityLineItems', window );"><strong>Variable Interest Entity [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromCollectionOfNotesReceivable', window );">Proceeds received from repayment of Viking note receivable</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 3,914<span></span>
</td>
<td class="nump">$ 200<span></span>
</td>
<td class="nump">$ 300<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1', window );">Value of consideration received for repayment of convertible notes</a></td>
<td class="nump">$ 3,900<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1', window );">Exercise price of warrants (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 125.08<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WarrantsAndRightsOutstanding', window );">Warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">9,300<span></span>
</td>
<td class="nump">$ 3,900<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeInstrumentRiskAxis=us-gaap_DebtMember', window );">Debt | Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityLineItems', window );"><strong>Variable Interest Entity [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount', window );">Convertible loan facility extended</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 2,500<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis=us-gaap_EquityMethodInvesteeMember', window );">Equity Method Investee</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityLineItems', window );"><strong>Variable Interest Entity [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EquityMethodInvestmentOwnershipPercentage', window );">Aggregate ownership (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">17.60%<span></span>
</td>
<td class="nump">30.30%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncreaseDecreaseinEquityMethodInvestment', window );">Increase (decrease) in equity method investment</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 2,700<span></span>
</td>
<td class="num">$ (10,700)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded', window );">Loss recorded (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">12.40%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_NoteReceivableAmountDueUponTriggeringEvent', window );">Amount of loan to be repaid upon consummation of first capital financing transaction</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 1,500<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromCollectionOfNotesReceivable', window );">Proceeds received from repayment of Viking note receivable</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 300<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement', window );">Shares received pursuant to MLA amendment (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">960,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_NoteReceivableCashDueUponTriggeringEvent', window );">Amount of loan to be repaid in cash upon consummation of first capital financing transaction</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 200<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1', window );">Exercise price of warrants (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 1.50<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ImpairmentOfInvestments', window );">Other than temporary impairment of investment in Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">7,400<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FinancialInstrumentAxis=us-gaap_WarrantMember', window );">Warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityLineItems', window );"><strong>Variable Interest Entity [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueOptionChangesInFairValueGainLoss1', window );">Gain on changes in fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 5,400<span></span>
</td>
<td class="nump">$ 3,200<span></span>
</td>
<td class="nump">$ 300<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_OwnershipAxis=lgnd_VikingTherapeuticsInc.Member', window );">Viking Therapeutics, Inc.</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_VariableInterestEntityLineItems', window );"><strong>Variable Interest Entity [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest', window );">Ownership interest (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">8.80%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Equity Method Investment, Shares Received, Licensing Agreement</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncreaseDecreaseinEquityMethodInvestment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Increase (Decrease) in Equity Method Investment</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncreaseDecreaseinEquityMethodInvestment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_NoteReceivableAmountDueUponTriggeringEvent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Note Receivable, Amount Due Upon Triggering Event</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_NoteReceivableAmountDueUponTriggeringEvent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_NoteReceivableCashDueUponTriggeringEvent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Note Receivable, Cash Due Upon Triggering Event</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_NoteReceivableCashDueUponTriggeringEvent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Variable Interest Entity, Qualitative or Quantitative Information, Loss Percentage Recorded</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Exercise price per share or per unit of warrants or rights outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(i)(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EquityMethodInvestmentOwnershipPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 323<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=114001798&amp;loc=d3e33918-111571<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EquityMethodInvestmentOwnershipPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueOptionChangesInFairValueGainLoss1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>For each line item in the statement of financial position, the amounts of gains and losses from fair value changes included in earnings.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 825<br> -SubTopic 10<br> -Section 50<br> -Paragraph 30<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=75031198&amp;loc=d3e14172-108612<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueOptionChangesInFairValueGainLoss1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ImpairmentOfInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount by which the fair value of an investment is less than the amortized cost basis or carrying amount of that investment at the balance sheet date and the decline in fair value is deemed to be other than temporary, before considering whether or not such amount is recognized in earnings or other comprehensive income.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 45<br> -Paragraph 8A<br> -URI http://asc.fasb.org/extlink&amp;oid=109979856&amp;loc=SL6284422-111562<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ImpairmentOfInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Percentage investment held by members or limited partners of limited liability company (LLC) or limited partnership (LP).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 272<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=6373374&amp;loc=d3e70478-108055<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The value of the noncash (or part noncash) consideration received in a transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of a transaction not resulting in cash receipts or cash payments in the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4313-108586<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4304-108586<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4332-108586<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromCollectionOfNotesReceivable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow associated with principal collections from a borrowing supported by a written promise to pay an obligation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 12<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3179-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromCollectionOfNotesReceivable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of financial or other support the reporting entity has provided (explicitly or implicitly) to the Variable Interest Entity (VIE) that it was not previously contractually required to provide or that the reporting entity intends to provide, including, for example, situations in which the reporting entity assisted the VIE in obtaining another type of support.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 810<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5A<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=108788376&amp;loc=SL6759159-111685<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VariableInterestEntityLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VariableInterestEntityLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WarrantsAndRightsOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(i))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WarrantsAndRightsOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeInstrumentRiskAxis=us-gaap_DebtMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeInstrumentRiskAxis=us-gaap_DebtMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis=us-gaap_VariableInterestEntityPrimaryBeneficiaryMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis=us-gaap_VariableInterestEntityPrimaryBeneficiaryMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis=us-gaap_EquityMethodInvesteeMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RelatedPartyTransactionsByRelatedPartyAxis=us-gaap_EquityMethodInvesteeMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FinancialInstrumentAxis=us-gaap_WarrantMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FinancialInstrumentAxis=us-gaap_WarrantMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_OwnershipAxis=lgnd_VikingTherapeuticsInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_OwnershipAxis=lgnd_VikingTherapeuticsInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>51
<FILENAME>R36.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6899333872">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Business Combinations - Narrative (Details)<br></strong></div></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1">1 Months Ended</th>
<th class="th" colspan="2">12 Months Ended</th>
</tr>
<tr>
<th class="th">
<div>Oct. 06, 2017 </div>
<div>USD ($) </div>
<div>numberOfCollaborationAgreements</div>
</th>
<th class="th">
<div>Jan. 08, 2016 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Oct. 31, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2017 </div>
<div>USD ($)</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent', window );">Revenue royalty payable on all Cydex-related revenue (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20.00%<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments', window );">Cydex-related revenue amount that triggers royalty payments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 15,000,000.0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife', window );">Finite-lived intangible asset, useful life</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">20 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 86,646,000<span></span>
</td>
<td class="nump">$ 85,959,000<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember', window );">Vernalis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesGross', window );">Gross payments to acquire business</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 43,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate', window );">Projected cash flow discount rate (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">34.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 3,740,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesGross', window );">Gross payments to acquire business</a></td>
<td class="nump">$ 27,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_WorkingCapitalAdjustment', window );">Working capital adjustment</a></td>
<td class="nump">2,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned', window );">Total share consideration</a></td>
<td class="nump">10,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CashPayable', window );">Cash payable to Crystal Shareholders</a></td>
<td class="nump">336,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration', window );">Fair value of contingent consideration</a></td>
<td class="nump">8,401,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="nump">$ 10,697,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member', window );">OMT</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesGross', window );">Gross payments to acquire business</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 96,006,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned', window );">Total share consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">77,373,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">59,969,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationConsiderationTransferred1', window );">Consideration transferred</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 173,400,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_DevelopedTechnologyRightsMember', window );">Core Technology | Vernalis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife', window );">Finite-lived intangible asset, useful life</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">9 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_DevelopedTechnologyRightsMember', window );">Core Technology | Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate', window );">Projected cash flow discount rate (as a percent)</a></td>
<td class="nump">10.80%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate', window );">Average cash flow discount rate (as a percent)</a></td>
<td class="nump">4.60%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife', window );">Finite-lived intangible asset, useful life</a></td>
<td class="text">20 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_DevelopedTechnologyRightsMember', window );">Core Technology | OMT</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate', window );">Projected cash flow discount rate (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">15.50%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife', window );">Finite-lived intangible asset, useful life</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">20 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember', window );">Threshold of Revenues above $15 million with Three Collaboration Agreements | Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent', window );">Revenue royalty payable on all Cydex-related revenue (as a percent)</a></td>
<td class="nump">10.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments', window );">Cydex-related revenue amount that triggers royalty payments</a></td>
<td class="nump">$ 15,000,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember', window );">Threshold of Revenues above $1.5 million with Four Collaboration Agreements | Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent', window );">Revenue royalty payable on all Cydex-related revenue (as a percent)</a></td>
<td class="nump">20.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments', window );">Cydex-related revenue amount that triggers royalty payments</a></td>
<td class="nump">$ 1,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_NumberofCollaborationAgreements', window );">Number of collaboration agreements | numberOfCollaborationAgreements</a></td>
<td class="nump">4<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business Combination, Assumptions Used Estimated Future Cash Flows, Average Discount Rate</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business Combination, Assumptions Used Estimated Future Cash Flows, Discount Rate</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CashPayable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash Payable</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CashPayable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_NumberofCollaborationAgreements">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of Collaboration Agreements</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_NumberofCollaborationAgreements</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:integerItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Revenue Royalty to Acquiree Shareholders, Percent</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RevenueRoyaltytoAcquireeShareholdersPercent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold Revenue Amount to Trigger Royalty Payments</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_WorkingCapitalAdjustment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Working Capital Adjustment</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_WorkingCapitalAdjustment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of equity interests (such as common shares, preferred shares, or partnership interest) issued or issuable to acquire the entity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(4)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationConsiderationTransferred1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of consideration transferred, consisting of acquisition-date fair value of assets transferred by the acquirer, liabilities incurred by the acquirer, and equity interest issued by the acquirer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 30<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=109124213&amp;loc=d3e6613-128477<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 30<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109124213&amp;loc=d3e6578-128477<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationConsiderationTransferred1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetUsefulLife</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Goodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=77989000&amp;loc=SL49117168-202975<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=99380562&amp;loc=d3e13770-109266<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Goodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquireBusinessesGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow associated with the acquisition of business during the period. The cash portion only of the acquisition price.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquireBusinessesGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_DevelopedTechnologyRightsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_DevelopedTechnologyRightsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_VariableRateComponentAxis=lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>52
<FILENAME>R37.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817877424">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Business Combinations - Assets Acquired and Liabilities Assumed (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Oct. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Oct. 06, 2017</div></th>
<th class="th"><div>Jan. 08, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="nump">$ 86,646<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 85,959<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember', window );">Vernalis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents', window );">Cash and cash equivalents</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 34,286<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash', window );">Restricted cash</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,836<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets', window );">Other assets</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">6,383<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable', window );">Accounts payable and accrued liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(3,403)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RestructuringReserve', window );">Restructuring and product reserves</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(7,118)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue', window );">Deferred revenue</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(746)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles', window );">Intangible asset with finite life - core technology</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">7,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,740<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet', window );">Total consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 42,978<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents', window );">Cash and cash equivalents</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 224<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables', window );">Accounts receivable</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,513<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets', window );">Prepaid expenses and other current assets</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">201<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment', window );">Property and equipment, net</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">589<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities', window );">Current liabilities assumed</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(354)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue', window );">Deferred revenue</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(4,624)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities', window );">Deferred tax liabilities, net</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(9,503)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles', window );">Intangible asset with finite life - core technology</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">36,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities', window );">Liabilities assumed</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(129)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10,697<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet', window );">Total consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 35,743<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member', window );">OMT</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents', window );">Cash and cash equivalents</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 3,504<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables', window );">Accounts receivable</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables', window );">Income tax receivable</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">136<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets', window );">Prepaid expenses and other current assets</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities', window );">Deferred tax liabilities, net</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(55,708)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles', window );">Intangible asset with finite life - core technology</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">167,000<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities', window );">Liabilities assumed</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(1,528)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">59,969<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet', window );">Total consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 173,379<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Restricted Cash</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Income Tax Receivables</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of currency on hand as well as demand deposits with banks or financial institutions, acquired at the acquisition date. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets that are expected to be realized or consumed within one year or the normal operating cycle, if longer, acquired at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount due from customers or clients for goods or services, including trade receivables, that have been delivered or sold in the normal course of business, and amounts due from others, including related parties expected to be converted to cash, sold or exchanged within one year or the normal operating cycle, if longer, acquired at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities due within one year or within the normal operating cycle, if longer, assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities incurred for goods and services received that are used in an entity's business and related party payables, assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred revenue expected to be recognized as such within one year or the normal operating cycle, if longer, assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred tax liability attributable to taxable temporary differences assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e31917-109318<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of identifiable intangible assets recognized as of the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 10<br> -Section 55<br> -Paragraph 37<br> -URI http://asc.fasb.org/extlink&amp;oid=108330185&amp;loc=d3e2207-128464<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount recognized as of the acquisition date for the identifiable assets acquired in excess of (less than) the aggregate liabilities assumed.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 10<br> -Section 55<br> -Paragraph 37<br> -URI http://asc.fasb.org/extlink&amp;oid=108330185&amp;loc=d3e2207-128464<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of other assets expected to be realized or consumed after one year or the normal operating cycle, if longer, acquired at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of property, plant, and equipment recognized as of the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 10<br> -Section 55<br> -Paragraph 37<br> -URI http://asc.fasb.org/extlink&amp;oid=108330185&amp;loc=d3e2207-128464<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Goodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=77989000&amp;loc=SL49117168-202975<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=99380562&amp;loc=d3e13770-109266<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Goodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RestructuringReserve">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying amount (including both current and noncurrent portions of the accrual) as of the balance sheet date pertaining to a specified type of cost associated with exit from or disposal of business activities or restructuring pursuant to a duly authorized plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 420<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=6394359&amp;loc=d3e17939-110869<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 420<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SAB TOPIC 5.P.4(b))<br> -URI http://asc.fasb.org/extlink&amp;oid=115931487&amp;loc=d3e140904-122747<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RestructuringReserve</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_VernalisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>53
<FILENAME>R38.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817440192">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Business Combinations - Consideration Transferred (Details) - USD ($)<br> $ / shares in Units, shares in Thousands</strong></div></th>
<th class="th"><div>Oct. 06, 2017</div></th>
<th class="th"><div>Jan. 08, 2016</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CashPaidtoAcquireBusiness', window );">Cash paid to Crystal shareholders</a></td>
<td class="nump">$ 26,877,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CashPayable', window );">Cash payable to Crystal Shareholders</a></td>
<td class="nump">336,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 200,000<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities', window );">Assumed liabilities</a></td>
<td class="nump">129,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration', window );">Fair value of contingent consideration</a></td>
<td class="nump">8,401,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesGross', window );">Cash consideration</a></td>
<td class="nump">27,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned', window );">Total share consideration</a></td>
<td class="nump">10,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet', window );">Total consideration</a></td>
<td class="nump">$ 35,743,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member', window );">OMT</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities', window );">Assumed liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 1,528,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsToAcquireBusinessesGross', window );">Cash consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 96,006,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued', window );">Actual number of shares issued (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">790<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharePrice', window );">Common stock price (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 98<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned', window );">Total share consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 77,373,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet', window );">Total consideration</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 173,379,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CashPaidtoAcquireBusiness">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash Paid to Acquire Business</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CashPaidtoAcquireBusiness</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CashPayable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cash Payable</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CashPayable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of equity interests (such as common shares, preferred shares, or partnership interest) issued or issuable to acquire the entity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(4)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares of equity interests issued or issuable to acquire entity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(4)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of liabilities assumed at the acquisition date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount recognized as of the acquisition date for the identifiable assets acquired in excess of (less than) the aggregate liabilities assumed.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 10<br> -Section 55<br> -Paragraph 37<br> -URI http://asc.fasb.org/extlink&amp;oid=108330185&amp;loc=d3e2207-128464<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 20<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84161108&amp;loc=d3e4845-128472<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsToAcquireBusinessesGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash outflow associated with the acquisition of business during the period. The cash portion only of the acquisition price.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 805<br> -SubTopic 30<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=35744584&amp;loc=d3e6927-128479<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 13<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3213-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsToAcquireBusinessesGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Price of a single share of a number of saleable stocks of a company.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_OMTInc.Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>54
<FILENAME>R39.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6914061792">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2017 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2016 </div>
<div>USD ($)</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements', window );">Notes receivable fair market value adjustment</a></td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease', window );">Increase (decrease) in notes receivable fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (900)<span></span>
</td>
<td class="num">$ (200)<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">656,665<span></span>
</td>
<td class="nump">188,764<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">12,741<span></span>
</td>
<td class="nump">14,245<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Contingent liabilities - Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">6,477<span></span>
</td>
<td class="nump">8,401<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Contingent liabilities - CyDex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">514<span></span>
</td>
<td class="nump">1,589<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Contingent liabilities - Metabasis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">5,551<span></span>
</td>
<td class="nump">3,971<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Liability for restricted investments owed to former licensees</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">199<span></span>
</td>
<td class="nump">284<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Short-term investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">647,408<span></span>
</td>
<td class="nump">181,041<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Notes receivable Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,877<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Investment in warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">9,257<span></span>
</td>
<td class="nump">3,846<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">56,774<span></span>
</td>
<td class="nump">5,742<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">199<span></span>
</td>
<td class="nump">284<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - CyDex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Contingent liabilities - Metabasis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Liability for restricted investments owed to former licensees</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">199<span></span>
</td>
<td class="nump">284<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Short-term investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">47,517<span></span>
</td>
<td class="nump">1,896<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Notes receivable Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Quoted Prices in Active Markets for Identical Assets (Level 1) | Investment in warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">9,257<span></span>
</td>
<td class="nump">3,846<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">599,891<span></span>
</td>
<td class="nump">179,145<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">5,551<span></span>
</td>
<td class="nump">3,971<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - CyDex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Contingent liabilities - Metabasis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">5,551<span></span>
</td>
<td class="nump">3,971<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Liability for restricted investments owed to former licensees</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Short-term investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">599,891<span></span>
</td>
<td class="nump">179,145<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Notes receivable Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Other Observable Inputs (Level 2) | Investment in warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">3,877<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">6,991<span></span>
</td>
<td class="nump">9,990<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">6,477<span></span>
</td>
<td class="nump">8,401<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - CyDex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">514<span></span>
</td>
<td class="nump">1,589<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Contingent liabilities - Metabasis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Liability for restricted investments owed to former licensees</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LiabilitiesFairValueDisclosure', window );">Liabilities, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Short-term investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Notes receivable Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,877<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember', window );">Recurring | Significant Unobservable Inputs (Level 3) | Investment in warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AssetsFairValueDisclosure', window );">Assets, fair value</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputPriceVolatilityMember', window );">Volatility | Recurring | Notes receivable Viking</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AlternativeInvestmentMeasurementInput', window );">Measurement input</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.75<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_TimingOfTransferOfGoodOrServiceAxis=us-gaap_TransferredOverTimeMember', window );">Transferred over Time | Phase 3 Clinical Trial</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ContractWithCustomerAssetGross', window );">Gross contract asset</a></td>
<td class="nump">10,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MaximumMember', window );">Maximum | Transferred over Time | Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ContractWithCustomerAssetGross', window );">Gross contract asset</a></td>
<td class="nump">375,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MaximumMember', window );">Maximum | Transferred over Time | Milestone Payments and Royalties</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems', window );"><strong>Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ContractWithCustomerAssetGross', window );">Gross contract asset</a></td>
<td class="nump">$ 529,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Convertible Notes Receivable, Fair Value, Period Increase (Decrease)</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AlternativeInvestmentMeasurementInput">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Value of input used to measure alternative investment.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (bbb)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AlternativeInvestmentMeasurementInput</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:decimalItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AssetsFairValueDisclosure">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AssetsFairValueDisclosure</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ContractWithCustomerAssetGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before allowance for credit loss, of right to consideration in exchange for good or service transferred to customer, when right is conditioned on something other than passage of time.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=82913815&amp;loc=SL49130531-203044<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130549-203045<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=82913815&amp;loc=SL49130533-203044<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ContractWithCustomerAssetGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of settlement of financial instrument classified as an asset measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LiabilitiesFairValueDisclosure">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value of financial and nonfinancial obligations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LiabilitiesFairValueDisclosure</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByMeasurementFrequencyAxis=us-gaap_FairValueMeasurementsRecurringMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyCrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyCrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyCydexMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyCydexMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByLiabilityClassAxis=lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByAssetClassAxis=us-gaap_ShortTermInvestmentsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByAssetClassAxis=us-gaap_ShortTermInvestmentsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByAssetClassAxis=us-gaap_NotesReceivableMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByAssetClassAxis=us-gaap_NotesReceivableMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByAssetClassAxis=us-gaap_WarrantMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByAssetClassAxis=us-gaap_WarrantMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel1Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel1Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel2Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel2Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel3Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel3Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputPriceVolatilityMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_MeasurementInputTypeAxis=us-gaap_MeasurementInputPriceVolatilityMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_TimingOfTransferOfGoodOrServiceAxis=us-gaap_TransferredOverTimeMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_TimingOfTransferOfGoodOrServiceAxis=us-gaap_TransferredOverTimeMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_Phase3ClinicalTrialMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_Phase3ClinicalTrialMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MaximumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MaximumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_ProductOrServiceAxis=lgnd_MilestonePaymentsAndRoyaltiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_ProductOrServiceAxis=lgnd_MilestonePaymentsAndRoyaltiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>55
<FILENAME>R40.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6818006800">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="2">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward', window );"><strong>Assets:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue', window );">Fair value of level 3 financial instruments at beginning of period</a></td>
<td class="nump">$ 3,877<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3', window );">Cash payment received as partial repayment of note receivable</a></td>
<td class="num">(3,877)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue', window );">Fair value of level 3 financial instruments at end of period</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">$ 3,877<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward', window );"><strong>Liabilities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue', window );">Fair value of level 3 financial instruments at beginning of period</a></td>
<td class="nump">9,990<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments to CVR holders and other contingency payments</a></td>
<td class="num">(4,925)<span></span>
</td>
<td class="num">(5,000)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair value adjustments to contingent liabilities</a></td>
<td class="nump">3,426<span></span>
</td>
<td class="nump">2,500<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue', window );">Fair value of level 3 financial instruments at end of period</a></td>
<td class="nump">6,991<span></span>
</td>
<td class="nump">9,990<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward', window );"><strong>Liabilities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments to CVR holders and other contingency payments</a></td>
<td class="num">(1,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair value adjustments to contingent liabilities</a></td>
<td class="num">(924)<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexMember', window );">Cydex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward', window );"><strong>Liabilities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments to CVR holders and other contingency payments</a></td>
<td class="num">(1,025)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexandCrystalMember', window );">Cydex and Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward', window );"><strong>Liabilities</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair value adjustments to contingent liabilities</a></td>
<td class="num">$ (1,974)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PaymentsToContingentValueRightHolders">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Payments to contingent value right holders</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PaymentsToContingentValueRightHolders</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of transfer of financial instrument classified as an asset into level 3 of the fair value hierarchy.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value of financial instrument classified as an asset measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 820<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=99377789&amp;loc=d3e19207-110258<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CydexMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexandCrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CydexandCrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>56
<FILENAME>R41.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6818778208">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Lease Obligations - Narrative (Details) - USD ($)<br> $ in Millions</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesAbstract', window );"><strong>Leases [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeaseAndRentalExpense', window );">Rent expense</a></td>
<td class="nump">$ 1.0<span></span>
</td>
<td class="nump">$ 0.3<span></span>
</td>
<td class="nump">$ 0.3<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeaseAndRentalExpense">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of rent expense incurred for leased assets, including but not limited to, furniture and equipment, that is not directly or indirectly associated with the manufacture, sale or creation of a product or product line.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeaseAndRentalExpense</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeasesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeasesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>57
<FILENAME>R42.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817875840">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Lease Obligations - Operating Lease Obligations and Payments (Details)<br> $ in Thousands</strong></div></th>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($)</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">$ 1,620<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears', window );">Operating lease obligation, 1-2 years</a></td>
<td class="nump">1,145<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears', window );">Operating leases obligation, 3-4 years</a></td>
<td class="nump">198<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">2,963<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet', window );">Operating lease obligation, Less than 1 year, net</a></td>
<td class="nump">1,260<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet', window );">Operating lease obligation, 1-2 years, net</a></td>
<td class="nump">1,145<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet', window );">Operating lease obligation, 3-4 years, net</a></td>
<td class="nump">198<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet', window );">Operating lease obligation, net, Total</a></td>
<td class="nump">2,603<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_CorporateHeadquartersSanDiegoCAMember', window );">Corporate headquarters-San Diego, CA | California</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">135<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears', window );">Operating lease obligation, 1-2 years</a></td>
<td class="nump">283<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears', window );">Operating leases obligation, 3-4 years</a></td>
<td class="nump">198<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">616<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeandResearchFacilityLaJollaCAMember', window );">Office and research facility-La Jolla, CA | California</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">373<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears', window );">Operating leases obligation, 3-4 years</a></td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">373<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths', window );">Sublease payments expected to be received, Less than 1 year</a></td>
<td class="nump">360<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears', window );">Sublease payments expected to be received, 1-2 years</a></td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears', window );">Sublease payments expected to be received, 3-4 years</a></td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals', window );">Sublease payments expected to be received, Total</a></td>
<td class="nump">360<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember', window );">Bioscience and Technology Business Center-Lawrence, KS | Kansas</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">57<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears', window );">Operating lease obligation, 1-2 years</a></td>
<td class="nump">56<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">113<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeEmeryvilleCAMember', window );">Office - Emeryville, CA | California</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">260<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears', window );">Operating lease obligation, 1-2 years</a></td>
<td class="nump">455<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">715<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityEmeryvilleCAMember', window );">Research Facility - Emeryville, CA | California</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">203<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears', window );">Operating lease obligation, 1-2 years</a></td>
<td class="nump">351<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">554<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeWinnershUnitedKingdomMember', window );">Office - Winnersh, United Kingdom | United Kingdom</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">43<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">43<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityCambridgeUnitedKingdomMember', window );">Research Facility - Cambridge, United Kingdom | United Kingdom</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LeasesOperatingAbstract', window );"><strong>Payments expected to received from sublease agreements</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent', window );">Operating lease obligation, Less than 1 year</a></td>
<td class="nump">549<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue', window );">Operating lease obligation, Total</a></td>
<td class="nump">$ 549<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due Next Twelve Months</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in One and Two Years</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in Three and Four Years</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments Due, Net</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments Due, Next Twelve Months, Net</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments, Due in One and Two Years</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments, Due in One and Two Years, Net</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments, Due in Three and Four Years</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Operating Leases, Future Minimum Payments, Due in Three and Four Years, Net</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LeasesOperatingAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LeasesOperatingAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 10<br> -Section 55<br> -Paragraph 40<br> -Subparagraph (Note 3)<br> -URI http://asc.fasb.org/extlink&amp;oid=82846649&amp;loc=d3e38371-112697<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 20<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=77902758&amp;loc=d3e41502-112717<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingLeasesFutureMinimumPaymentsDue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 20<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=77902758&amp;loc=d3e41502-112717<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 10<br> -Section 55<br> -Paragraph 40<br> -Subparagraph (Note 3)<br> -URI http://asc.fasb.org/extlink&amp;oid=82846649&amp;loc=d3e38371-112697<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Contractually required future rental payments receivable on noncancelable subleasing arrangements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 840<br> -SubTopic 20<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=77902758&amp;loc=d3e41502-112717<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_CorporateHeadquartersSanDiegoCAMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_CorporateHeadquartersSanDiegoCAMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_StatementGeographicalAxis=stpr_CA">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_StatementGeographicalAxis=stpr_CA</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeandResearchFacilityLaJollaCAMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeandResearchFacilityLaJollaCAMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_StatementGeographicalAxis=stpr_KS">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_StatementGeographicalAxis=stpr_KS</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeEmeryvilleCAMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeEmeryvilleCAMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityEmeryvilleCAMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityEmeryvilleCAMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeWinnershUnitedKingdomMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_OfficeWinnershUnitedKingdomMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_StatementGeographicalAxis=country_GB">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_StatementGeographicalAxis=country_GB</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityCambridgeUnitedKingdomMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis=lgnd_ResearchFacilityCambridgeUnitedKingdomMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>58
<FILENAME>R43.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6905933824">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Convertible Senior Notes - Narrative (Details)<br></strong></div></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="4">1 Months Ended</th>
<th class="th" colspan="3">2 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($) </div>
<div>$ / shares </div>
<div>shares</div>
</th>
<th class="th">
<div>May 22, 2018 </div>
<div>USD ($) </div>
<div>$ / shares </div>
<div>shares</div>
</th>
<th class="th">
<div>Nov. 30, 2018 </div>
<div>USD ($) </div>
<div>shares</div>
</th>
<th class="th">
<div>Jun. 19, 2018 </div>
<div>USD ($) </div>
<div>$ / shares</div>
</th>
<th class="th">
<div>May 31, 2018 </div>
<div>trading_day</div>
</th>
<th class="th">
<div>Aug. 31, 2014 </div>
<div>USD ($) </div>
<div>day </div>
<div>trading_day </div>
<div>$ / shares </div>
<div>shares</div>
</th>
<th class="th">
<div>Nov. 30, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Aug. 31, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Apr. 30, 2018 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2018 </div>
<div>USD ($) </div>
<div>$ / shares </div>
<div>shares</div>
</th>
<th class="th">
<div>Dec. 31, 2017 </div>
<div>USD ($)</div>
</th>
<th class="th">
<div>Dec. 31, 2016 </div>
<div>USD ($)</div>
</th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Carrying value of equity component of convertible notes</a></td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="nump">$ 18,859,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights', window );">Warrants issued in public offering (shares) | shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,264,643<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeAssetsCurrent', window );">Derivative asset</a></td>
<td class="nump">22,576,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">22,576,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeGainLossOnDerivativeNet', window );">Net change in fair value of derivatives</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1', window );">Warrant exercise price (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 125.08<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued', window );">Value of warrants issued</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 11,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt', window );">Debt issuance costs related to the equity component of convertible debt</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">18,859,000<span></span>
</td>
<td class="nump">10,704,000<span></span>
</td>
<td class="nump">$ 10,065,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConvertibleDebtNoncurrent', window );">Convertible debt, noncurrent</a></td>
<td class="nump">$ 609,864,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">609,864,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_WarrantsSettled', window );">Warrants settled (in shares) | shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">525,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled', window );">Deduction to additional paid-in-capital for warrants settled</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">28,300,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PaymentsForRepurchaseOfWarrants', window );">Payments for repurchase of warrants</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 30,100,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">30,094,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeGainLossOnDerivativeNet', window );">Gain (loss) on derivative liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (1,800,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightOutstanding', window );">Warrants outstanding (in shares) | shares</a></td>
<td class="nump">2,739,643<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">2,739,643<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member', window );">2023 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued', window );">Value of warrants issued</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 97,805,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentFaceAmount', window );">Principal amount outstanding</a></td>
<td class="nump">$ 27,326,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">245,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">27,326,000<span></span>
</td>
<td class="nump">245,000,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromDebtNetOfIssuanceCosts', window );">Net proceeds from debt issuance</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 239,300,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentInterestRateEffectivePercentage', window );">Effective rate (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5.83%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleConversionRatio1', window );">Convertible debt conversion ratio</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.0133251<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleConversionPrice1', window );">Debt conversion price per share (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentInterestRateStatedPercentage', window );">Interest on debt instrument (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.75%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal', window );">If-converted value in excess of principal</a></td>
<td class="nump">$ 23,400,000<span></span>
</td>
<td class="nump">$ 341,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal', window );">Increase (decrease) in if-converted value in excess of principal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">118,700,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtConversionConvertedInstrumentAmount1', window );">Notices for conversion</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 195,900,000<span></span>
</td>
<td class="nump">$ 21,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature', window );">Conversion value over the principal amount</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 439,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 31,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_GainsLossesOnExtinguishmentOfDebt', window );">Gain (loss) on extinguishment of debt</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">$ (3,200,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share) | $ / shares</a></td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 75.05<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsforConvertibleBondHedges', window );">Payments for convertible bond hedges</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 48,100,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeAssetsCurrent', window );">Derivative asset</a></td>
<td class="nump">$ 22,600,000<span></span>
</td>
<td class="nump">$ 340,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 22,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeGainLossOnDerivativeNet', window );">Net change in fair value of derivatives</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(119,400,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities', window );">Proceeds from derivative instrument</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">471,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DerivativeGainLossOnDerivativeNet', window );">Gain (loss) on derivative liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">119,400,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Redemption Period One</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdTradingDays', window );">Number of trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1', window );">Number of consecutive trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">30<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger', window );">Stock price trigger to classify convertible debt as current (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">130.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes | Redemption Period Two</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdTradingDays', window );">Number of trading days | day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1', window );">Number of consecutive trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger', window );">Maximum threshold of debt trading price trigger (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">98.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentFaceAmount', window );">Principal amount outstanding</a></td>
<td class="nump">750,000,000<span></span>
</td>
<td class="nump">750,000,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">750,000,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromDebtNetOfIssuanceCosts', window );">Net proceeds from debt issuance</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 733,100,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleConversionRatio1', window );">Convertible debt conversion ratio</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.0040244<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleConversionPrice1', window );">Debt conversion price per share (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 248.48<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentInterestRateStatedPercentage', window );">Interest on debt instrument (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0.75%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Carrying value of equity component of convertible notes</a></td>
<td class="nump">$ 127,997,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">127,997,000<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights', window );">Warrants issued in public offering (shares) | shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,018,327<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ExercisePriceofConvertibleBondHedge', window );">Exercise price of convertible bond hedge (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 248.48<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 248.48<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsforConvertibleBondHedges', window );">Payments for convertible bond hedges</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 140,300,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1', window );">Warrant exercise price (USD per share) | $ / shares</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 315.38<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued', window );">Value of warrants issued</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 90,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability', window );">Fair value of the conversion option derivative liability</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">144,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredFinanceCostsGross', window );">Debt issuance costs</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">16,900,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt', window );">Debt issuance costs related to the equity component of convertible debt</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentUnamortizedPremium', window );">Debt issuance costs related to the liability component of convertible debt</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 13,700,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInDerivativeAssets', window );">Increase (decrease) in derivative assets</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">19,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncreaseDecreaseInDerivativeLiabilities', window );">Increase (decrease) in derivative liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 13,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 7,500,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Redemption Period One</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdTradingDays', window );">Number of trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1', window );">Number of consecutive trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">30<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger', window );">Stock price trigger to classify convertible debt as current (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">130.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes | Redemption Period Two</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentLineItems', window );"><strong>Debt Instrument [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdTradingDays', window );">Number of trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">5<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1', window );">Number of consecutive trading days | trading_day</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger', window );">Maximum threshold of debt trading price trigger (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">98.00%<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustments to Additional Paid in Capital, Warrants Settled</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Debt Instrument, Convertible, Increase (Decrease) If-Converted Value in Excess of Principal</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Debt Instrument, Convertible, Maximum Threshold Percentage of Debt Trading Price Trigger</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ExercisePriceofConvertibleBondHedge">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Exercise Price of Convertible Bond Hedge</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ExercisePriceofConvertibleBondHedge</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PaymentsforConvertibleBondHedges">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Payments for Convertible Bond Hedges</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PaymentsforConvertibleBondHedges</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_WarrantsSettled">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Warrants Settled</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_WarrantsSettled</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Adjustment to additional paid in capital resulting from the recognition of convertible debt instruments as two separate components - a debt component and an equity component. This bifurcation may result in a basis difference associated with the liability component that represents a temporary difference for purposes of applying accounting for income taxes. The initial recognition of deferred taxes for the tax effect of that temporary difference is as an adjustment to additional paid in capital.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 25<br> -Paragraph 22<br> -URI http://asc.fasb.org/extlink&amp;oid=51819886&amp;loc=SL6014347-161799<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase in additional paid in capital (APIC) resulting from the issuance of warrants. Includes allocation of proceeds of debt securities issued with detachable stock purchase warrants.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 25<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109126253&amp;loc=d3e4724-112606<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Exercise price per share or per unit of warrants or rights outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(i)(4))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(i)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ClassOfWarrantOrRightOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of warrants or rights outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(i))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ClassOfWarrantOrRightOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConvertibleDebtNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying amount of long-term convertible debt as of the balance sheet date, net of the amount due in the next twelve months or greater than the normal operating cycle, if longer. The debt is convertible into another form of financial instrument, typically the entity's common stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConvertibleDebtNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtConversionConvertedInstrumentAmount1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The value of the financial instrument(s) that the original debt is being converted into in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4304-108586<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=d3e4332-108586<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtConversionConvertedInstrumentAmount1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of a favorable spread to a debt holder between the amount of debt being converted and the value of the securities received upon conversion. This is an embedded conversion feature of convertible debt issued that is in-the-money at the commitment date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21538-112644<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The carrying amount of the equity component of convertible debt which may be settled in cash upon conversion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031897-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleConversionPrice1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The price per share of the conversion feature embedded in the debt instrument.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031898-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleConversionPrice1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleConversionRatio1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Ratio applied to the conversion of debt instrument into equity with equity shares divided by debt principal amount.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21521-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21506-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22(a)(5))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21475-112644<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleConversionRatio1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:pureItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount by which the convertible debt's if-converted value exceeds its principle amount at the balance sheet date, regardless of whether the instrument is currently convertible. This element applies to public companies only.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 5<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031898-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold period of specified consecutive trading days within which common stock price to conversion price of convertible debt instrument must exceed threshold percentage for specified number of trading days to trigger conversion feature.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:integerItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Minimum percentage of common stock price to conversion price of convertible debt instruments to determine eligibility of conversion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleThresholdTradingDays">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold number of specified trading days that common stock price to conversion price of convertible debt instruments must exceed threshold percentage within a specified consecutive trading period to trigger conversion feature.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleThresholdTradingDays</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:integerItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentFaceAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Face (par) amount of debt instrument at time of issuance.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28551-108399<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 55<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=114775985&amp;loc=d3e28878-108400<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentFaceAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentInterestRateEffectivePercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 6<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6036836-161870<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28551-108399<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22(a)(1))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentInterestRateEffectivePercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentInterestRateStatedPercentage">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Contractual interest rate for funds borrowed, under the debt agreement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22(a)(1))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentInterestRateStatedPercentage</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentUnamortizedPremium">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, after accumulated amortization, of debt premium.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 55<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=114775985&amp;loc=d3e28878-108400<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 1A<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28541-108399<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentUnamortizedPremium</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredFinanceCostsGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 3<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28555-108399<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredFinanceCostsGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeAssetsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value, after the effects of master netting arrangements, of a financial asset or other contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 20<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=51824906&amp;loc=SL20225862-175312<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeAssetsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DerivativeGainLossOnDerivativeNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in the fair value of derivatives recognized in the income statement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4A<br> -Subparagraph (b)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5618551-113959<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DerivativeGainLossOnDerivativeNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 815<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4B<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=109980867&amp;loc=SL5624163-113959<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_GainsLossesOnExtinguishmentOfDebt">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 50<br> -Section 40<br> -Paragraph 4<br> -URI http://asc.fasb.org/extlink&amp;oid=114001942&amp;loc=d3e12355-112629<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 50<br> -Section 40<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=114001942&amp;loc=d3e12317-112629<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_GainsLossesOnExtinguishmentOfDebt</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInDerivativeAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the period in the carrying value of derivative instruments reported as assets that are due to be disposed of within one year (or the normal operating cycle, if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInDerivativeAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncreaseDecreaseInDerivativeLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The increase (decrease) during the period in the carrying value of derivative instruments reported as liabilities that are due to be disposed of within one year (or the normal operating cycle, if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncreaseDecreaseInDerivativeLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PaymentsForRepurchaseOfWarrants">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate amount paid by the entity to reacquire the right to purchase equity shares at a predetermined price, usually issued together with corporate debt.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3291-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PaymentsForRepurchaseOfWarrants</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromDebtNetOfIssuanceCosts">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow from additional borrowings, net of cash paid to third parties in connection with debt origination.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromDebtNetOfIssuanceCosts</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The cash inflow provided by derivative instruments during the period, which are classified as investing activities, excluding those designated as hedging instruments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3179-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentRedemptionPeriodAxis=us-gaap_DebtInstrumentRedemptionPeriodOneMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentRedemptionPeriodAxis=us-gaap_DebtInstrumentRedemptionPeriodOneMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentRedemptionPeriodAxis=us-gaap_DebtInstrumentRedemptionPeriodTwoMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentRedemptionPeriodAxis=us-gaap_DebtInstrumentRedemptionPeriodTwoMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>59
<FILENAME>R44.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6888552960">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details) - USD ($)<br></strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>May 22, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Aug. 31, 2014</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract', window );"><strong>Notes Payable, Current and Noncurrent</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Carrying value of equity component of 2023 Notes</a></td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 18,859,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract', window );"><strong>Notes Payable, Current and Noncurrent</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NotesPayableCurrent', window );">Total current portion of notes payable</a></td>
<td class="nump">26,433,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">224,529,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongTermNotesPayable', window );">Total long-term portion of notes payable</a></td>
<td class="nump">609,864,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ConvertibleDebtFairValueDisclosures', window );">Fair value of convertible senior notes outstanding (Level 2)</a></td>
<td class="nump">713,533,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">446,360,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2019 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract', window );"><strong>Notes Payable, Current and Noncurrent</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentFaceAmount', window );">Principal amount outstanding</a></td>
<td class="nump">27,326,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">245,000,000<span></span>
</td>
<td class="nump">$ 245,000,000.0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentUnamortizedDiscount', window );">Unamortized discount</a></td>
<td class="num">(893,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(20,471,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember', window );">Convertible Notes | 2023 Convertible Senior Notes</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract', window );"><strong>Notes Payable, Current and Noncurrent</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentFaceAmount', window );">Principal amount outstanding</a></td>
<td class="nump">750,000,000<span></span>
</td>
<td class="nump">$ 750,000,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentUnamortizedDiscount', window );">Unamortized discount</a></td>
<td class="num">(140,136,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent', window );">Carrying value of equity component of 2023 Notes</a></td>
<td class="nump">$ 127,997,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ConvertibleDebtFairValueDisclosures">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair value portion of borrowing which can be exchanged for a specified number of another security at the option of the issuer or the holder, for example, but not limited to, the entity's common stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ConvertibleDebtFairValueDisclosures</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The carrying amount of the equity component of convertible debt which may be settled in cash upon conversion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 470<br> -SubTopic 20<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109500613&amp;loc=SL6031897-161870<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentFaceAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Face (par) amount of debt instrument at time of issuance.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28551-108399<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 55<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=114775985&amp;loc=d3e28878-108400<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentFaceAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentUnamortizedDiscount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, after accumulated amortization, of debt discount.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 45<br> -Paragraph 1A<br> -URI http://asc.fasb.org/extlink&amp;oid=114775744&amp;loc=d3e28541-108399<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 835<br> -SubTopic 30<br> -Section 55<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=114775985&amp;loc=d3e28878-108400<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentUnamortizedDiscount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongTermNotesPayable">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of notes payable (with maturities initially due after one year or beyond the operating cycle if longer), excluding current portion.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.22)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongTermNotesPayable</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NotesPayableCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Sum of the carrying values as of the balance sheet date of the portions of long-term notes payable due within one year or the operating cycle if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.19,20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NotesPayableCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_LongtermDebtTypeAxis=us-gaap_ConvertibleNotesPayableMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2019Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DebtInstrumentAxis=lgnd_ConvertibleSeniorNotes2023Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>60
<FILENAME>R45.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6815368160">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Balance Sheet Account Details - Investment Categories (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_ShortTermInvestmentsMember', window );">Short-term investments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">$ 600,154<span></span>
</td>
<td class="nump">$ 179,528<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">1,226<span></span>
</td>
<td class="nump">1,695<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(163)<span></span>
</td>
<td class="num">(182)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">601,217<span></span>
</td>
<td class="nump">181,041<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_DemandDepositsMember', window );">Bank deposits</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">311,066<span></span>
</td>
<td class="nump">80,095<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">26<span></span>
</td>
<td class="nump">6<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(29)<span></span>
</td>
<td class="num">(42)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">311,063<span></span>
</td>
<td class="nump">80,059<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_CorporateDebtSecuritiesMember', window );">Corporate bonds</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">53,223<span></span>
</td>
<td class="nump">55,335<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">1<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(45)<span></span>
</td>
<td class="num">(96)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">53,179<span></span>
</td>
<td class="nump">55,239<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_EquitySecuritiesMember', window );">Corporate equity securities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">135<span></span>
</td>
<td class="nump">207<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">1,191<span></span>
</td>
<td class="nump">1,689<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">1,326<span></span>
</td>
<td class="nump">1,896<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_CommercialPaperMember', window );">Commercial paper</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">225,731<span></span>
</td>
<td class="nump">27,933<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">8<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(76)<span></span>
</td>
<td class="num">(20)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">225,663<span></span>
</td>
<td class="nump">27,913<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_USGovernmentAgenciesDebtSecuritiesMember', window );">Agency bonds</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">4,991<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(1)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">4,990<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_USTreasurySecuritiesMember', window );">U.S. Government bonds</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">7,982<span></span>
</td>
<td class="nump">8,939<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(9)<span></span>
</td>
<td class="num">(10)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">7,973<span></span>
</td>
<td class="nump">8,929<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_InvestmentTypeAxis=us-gaap_MunicipalBondsMember', window );">Municipal bonds</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems', window );"><strong>Debt Securities, Available-for-sale [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis', window );">Cost</a></td>
<td class="nump">2,017<span></span>
</td>
<td class="nump">2,028<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax', window );">Gross unrealized gains</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax', window );">Gross unrealized losses</a></td>
<td class="num">(4)<span></span>
</td>
<td class="num">(13)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities', window );">Estimated fair value</a></td>
<td class="nump">$ 2,013<span></span>
</td>
<td class="nump">$ 2,015<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=82897076&amp;loc=d3e27161-111563<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before tax, of unrealized loss in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=82897076&amp;loc=d3e27161-111563<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=82897076&amp;loc=d3e27161-111563<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AvailableForSaleSecuritiesDebtSecurities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109979856&amp;loc=d3e26610-111562<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 320<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (aa)<br> -URI http://asc.fasb.org/extlink&amp;oid=82897076&amp;loc=d3e27161-111563<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AvailableForSaleSecuritiesDebtSecurities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_ShortTermInvestmentsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_ShortTermInvestmentsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_DemandDepositsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_DemandDepositsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_CorporateDebtSecuritiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_CorporateDebtSecuritiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_EquitySecuritiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_EquitySecuritiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_CommercialPaperMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_CommercialPaperMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_USGovernmentAgenciesDebtSecuritiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_USGovernmentAgenciesDebtSecuritiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_USTreasurySecuritiesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_USTreasurySecuritiesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_InvestmentTypeAxis=us-gaap_MunicipalBondsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_InvestmentTypeAxis=us-gaap_MunicipalBondsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>61
<FILENAME>R46.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6887636976">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Balance Sheet Account Details - Other Current Assets (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OtherBalanceSheetDetailsAbstract', window );"><strong>Other Balance Sheet Details [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RestrictedCashCurrent', window );">Restricted cash</a></td>
<td class="nump">$ 2,616<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_WarrantsCurrent', window );">Investment in Viking warrants</a></td>
<td class="nump">9,257<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OtherAssetsCurrentOther', window );">Other</a></td>
<td class="nump">8,545<span></span>
</td>
<td class="nump">1,514<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherAssetsCurrent', window );">Other current assets</a></td>
<td class="nump">$ 20,418<span></span>
</td>
<td class="nump">$ 1,514<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OtherAssetsCurrentOther">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Other Assets, Current, Other</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OtherAssetsCurrentOther</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OtherBalanceSheetDetailsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Other Balance Sheet Details [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OtherBalanceSheetDetailsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_WarrantsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Warrants, Current</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_WarrantsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherAssetsCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current assets classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.8)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherAssetsCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RestrictedCashCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=98513485&amp;loc=SL98516268-108586<br><br>Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(1))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6676-107765<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RestrictedCashCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>62
<FILENAME>R47.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6818006272">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Balance Sheet Account Details - Property and Equipment (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentGross', window );">Property and equipment , gross</a></td>
<td class="nump">$ 7,537<span></span>
</td>
<td class="nump">$ 6,074<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment', window );">Less accumulated depreciation and amortization</a></td>
<td class="num">(2,165)<span></span>
</td>
<td class="num">(1,862)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentNet', window );">Property and equipment, net</a></td>
<td class="nump">5,372<span></span>
</td>
<td class="nump">4,212<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Depreciation', window );">Depreciation expense</a></td>
<td class="nump">900<span></span>
</td>
<td class="nump">400<span></span>
</td>
<td class="nump">$ 200<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_OfficeEquipmentMember', window );">Lab and office equipment</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentGross', window );">Property and equipment , gross</a></td>
<td class="nump">4,183<span></span>
</td>
<td class="nump">3,460<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_LeaseholdImprovementsMember', window );">Leasehold improvements</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentGross', window );">Property and equipment , gross</a></td>
<td class="nump">2,418<span></span>
</td>
<td class="nump">1,917<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=lgnd_ComputerEquipmentAndSoftwareMember', window );">Computer equipment and software</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentGross', window );">Property and equipment , gross</a></td>
<td class="nump">$ 936<span></span>
</td>
<td class="nump">$ 697<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MinimumMember', window );">Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentUsefulLife', window );">Property and equipment, useful life</a></td>
<td class="text">3 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MaximumMember', window );">Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentLineItems', window );"><strong>Property, Plant and Equipment [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PropertyPlantAndEquipmentUsefulLife', window );">Property and equipment, useful life</a></td>
<td class="text">10 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.14)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Depreciation">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Depreciation</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.13)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(14))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 360<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6391035&amp;loc=d3e2868-110229<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(8))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(13))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentUsefulLife">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentUsefulLife</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_OfficeEquipmentMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_OfficeEquipmentMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_LeaseholdImprovementsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentByTypeAxis=us-gaap_LeaseholdImprovementsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PropertyPlantAndEquipmentByTypeAxis=lgnd_ComputerEquipmentAndSoftwareMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PropertyPlantAndEquipmentByTypeAxis=lgnd_ComputerEquipmentAndSoftwareMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MinimumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MinimumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MaximumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MaximumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>63
<FILENAME>R48.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6906405104">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details) - USD ($)<br></strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_Goodwill', window );">Goodwill</a></td>
<td class="nump">$ 86,646,000<span></span>
</td>
<td class="nump">$ 85,959,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IntangibleAssetsNetIncludingGoodwill', window );">Total goodwill and other identifiable intangible assets, net</a></td>
<td class="nump">$ 306,439,000<span></span>
</td>
<td class="nump">314,543,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife', window );">Finite-lived intangible asset, useful life</a></td>
<td class="text">20 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AmortizationOfIntangibleAssets', window );">Amortization expense</a></td>
<td class="nump">$ 15,800,000<span></span>
</td>
<td class="nump">11,300,000<span></span>
</td>
<td class="nump">$ 10,600,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths', window );">Amortization expense, 2019</a></td>
<td class="nump">13,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo', window );">Amortization expense, 2020</a></td>
<td class="nump">12,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree', window );">Amortization expense, 2021</a></td>
<td class="nump">12,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour', window );">Amortization expense, 2022</a></td>
<td class="nump">12,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive', window );">Amortization expense, 2023</a></td>
<td class="nump">12,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ImpairmentOfIntangibleAssetsFinitelived', window );">Impairment of intangible assets with finite lives</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_PatentedTechnologyMember', window );">Complete technology</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">235,413,000<span></span>
</td>
<td class="nump">222,900,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization', window );">Less: Accumulated amortization</a></td>
<td class="num">(35,070,000)<span></span>
</td>
<td class="num">(23,301,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_TradeNamesMember', window );">Trade name</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">2,642,000<span></span>
</td>
<td class="nump">2,642,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization', window );">Less: Accumulated amortization</a></td>
<td class="num">(1,048,000)<span></span>
</td>
<td class="num">(916,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_CustomerRelationshipsMember', window );">Customer relationships</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsGross', window );">Definite lived intangible assets</a></td>
<td class="nump">29,600,000<span></span>
</td>
<td class="nump">29,600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization', window );">Less: Accumulated amortization</a></td>
<td class="num">$ (11,744,000)<span></span>
</td>
<td class="num">(10,264,000)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis=lgnd_AcquiredInProcessResearchAndDevelopmentMember', window );">IPR&amp;D</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_FiniteLivedIntangibleAssetsLineItems', window );"><strong>Finite-Lived Intangible Assets [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill', window );">IPR&amp;D</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 7,923,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AmortizationOfIntangibleAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=6388964&amp;loc=d3e16225-109274<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AmortizationOfIntangibleAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetUsefulLife">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetUsefulLife</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accumulated amount of amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the fifth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the fourth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the third fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 928<br> -SubTopic 340<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6473545&amp;loc=d3e61844-108004<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_Goodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=77989000&amp;loc=SL49117168-202975<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 20<br> -Section 45<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=99380562&amp;loc=d3e13770-109266<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_Goodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ImpairmentOfIntangibleAssetsFinitelived">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of a finite-lived intangible asset to fair value.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16373-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ImpairmentOfIntangibleAssetsFinitelived</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 350<br> -SubTopic 30<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=66006027&amp;loc=d3e16323-109275<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IntangibleAssetsNetIncludingGoodwill">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying amount of finite-lived intangible assets, indefinite-lived intangible assets and goodwill. Goodwill is an asset representing the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized. Intangible assets are assets, not including financial assets, lacking physical substance.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IntangibleAssetsNetIncludingGoodwill</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_PatentedTechnologyMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_PatentedTechnologyMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_TradeNamesMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_TradeNamesMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_CustomerRelationshipsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis=us-gaap_CustomerRelationshipsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis=lgnd_AcquiredInProcessResearchAndDevelopmentMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis=lgnd_AcquiredInProcessResearchAndDevelopmentMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>64
<FILENAME>R49.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6817650256">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Balance Sheet Account Details - Accrued Liabilities (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_OtherBalanceSheetDetailsAbstract', window );"><strong>Other Balance Sheet Details [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmployeeRelatedLiabilitiesCurrent', window );">Compensation</a></td>
<td class="nump">$ 4,045<span></span>
</td>
<td class="nump">$ 4,085<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccruedProfessionalFeesCurrent', window );">Legal</a></td>
<td class="nump">942<span></span>
</td>
<td class="nump">430<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent', window );">Amounts owed to former licensees</a></td>
<td class="nump">428<span></span>
</td>
<td class="nump">396<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent', window );">Royalties owed to third parties</a></td>
<td class="nump">1,025<span></span>
</td>
<td class="nump">954<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AccruedStockRepurchases', window );">Payments due to broker for share repurchase</a></td>
<td class="nump">4,613<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AccruedSalesReturns', window );">Return reserve</a></td>
<td class="nump">3,590<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RestructuringReserveCurrent', window );">Restructuring</a></td>
<td class="nump">1,093<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OtherAccruedLiabilitiesCurrent', window );">Other</a></td>
<td class="nump">3,464<span></span>
</td>
<td class="nump">1,512<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AccruedLiabilitiesCurrent', window );">Accrued liabilities</a></td>
<td class="nump">$ 19,200<span></span>
</td>
<td class="nump">$ 7,377<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AccruedSalesReturns">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accrued Sales Returns</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AccruedSalesReturns</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AccruedStockRepurchases">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Accrued Stock Repurchases</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AccruedStockRepurchases</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_OtherBalanceSheetDetailsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Other Balance Sheet Details [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_OtherBalanceSheetDetailsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccruedLiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccruedLiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccruedProfessionalFeesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6911-107765<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6935-107765<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccruedProfessionalFeesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccruedRoyaltiesCurrentAndNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of obligations incurred through that date and payable for royalties.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03.15(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03.15(5))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccruedRoyaltiesCurrentAndNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AccruedSalesCommissionCurrentAndNoncurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying value as of the balance sheet date of obligations incurred through that date and payable for sales commissions.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(a)(15)(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(15)(5))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(24))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AccruedSalesCommissionCurrentAndNoncurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EmployeeRelatedLiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EmployeeRelatedLiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OtherAccruedLiabilitiesCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of expenses incurred but not yet paid classified as other, due within one year or the normal operating cycle, if longer.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02.20)<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6911-107765<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 9<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e7018-107765<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section 45<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=82887183&amp;loc=d3e6935-107765<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OtherAccruedLiabilitiesCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RestructuringReserveCurrent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Carrying amount as of the balance sheet date of known and estimated obligations associated with exit from or disposal of business activities or restructurings pursuant to a duly authorized plan, which are expected to be paid in the next twelve months or in the normal operating cycle if longer. Costs of such activities include those for one-time termination benefits, termination of an operating lease or other contract, consolidating or closing facilities, relocating employees, and costs associated with an ongoing benefit arrangement, but excludes costs associated with the retirement of a long-lived asset.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 420<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=6394359&amp;loc=d3e17939-110869<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 420<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SAB Topic 5.P.4(b)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=115931487&amp;loc=d3e140904-122747<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RestructuringReserveCurrent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>65
<FILENAME>R50.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6915073888">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Balance Sheet Account Details - Contingent Liabilities (Details) - USD ($)<br></strong></div></th>
<th class="th" colspan="2">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionLineItems', window );"><strong>Business Acquisition [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent', window );">Revenue royalty payable on all Cydex-related revenue (as a percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">20.00%<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments', window );">Cydex-related revenue amount that triggers royalty payments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 15,000,000.0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent', window );">Additional revenue royalty payable when higher threshold of Cydex-related revenue met (percent)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">10.00%<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments', window );">Cydex-related revenue amount that triggers additional royalty payments</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 35,000,000.0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ContingentLiabilityRollForward', window );"><strong>Contingent Liability [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at beginning of period</a></td>
<td class="nump">$ 14,000,000<span></span>
</td>
<td class="nump">8,100,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments</a></td>
<td class="num">(4,925,000)<span></span>
</td>
<td class="num">(5,000,000)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair Value Adjustment</a></td>
<td class="nump">3,426,000<span></span>
</td>
<td class="nump">2,500,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions', window );">Additions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">8,400,000<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at end of period</a></td>
<td class="nump">12,501,000<span></span>
</td>
<td class="nump">14,000,000<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexPharmaceuticalsIncMember', window );">Cydex</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ContingentLiabilityRollForward', window );"><strong>Contingent Liability [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at beginning of period</a></td>
<td class="nump">1,600,000<span></span>
</td>
<td class="nump">6,600,000<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments</a></td>
<td class="num">(25,000)<span></span>
</td>
<td class="num">(5,000,000)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair Value Adjustment</a></td>
<td class="num">(1,050,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions', window );">Additions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at end of period</a></td>
<td class="nump">525,000<span></span>
</td>
<td class="nump">1,600,000<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember', window );">Metabasis</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ContingentLiabilityRollForward', window );"><strong>Contingent Liability [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at beginning of period</a></td>
<td class="nump">4,000,000<span></span>
</td>
<td class="nump">1,500,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments</a></td>
<td class="num">(3,900,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair Value Adjustment</a></td>
<td class="nump">5,400,000<span></span>
</td>
<td class="nump">2,500,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions', window );">Additions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at end of period</a></td>
<td class="nump">5,500,000<span></span>
</td>
<td class="nump">4,000,000<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember', window );">Crystal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_ContingentLiabilityRollForward', window );"><strong>Contingent Liability [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at beginning of period</a></td>
<td class="nump">8,400,000<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_PaymentsToContingentValueRightHolders', window );">Payments</a></td>
<td class="num">(1,000,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities', window );">Fair Value Adjustment</a></td>
<td class="num">(924,000)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions', window );">Additions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">8,400,000<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod', window );">Commercial rights at end of period</a></td>
<td class="nump">$ 6,476,000<span></span>
</td>
<td class="nump">$ 8,400,000<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Additional Revenue Royalty to Acquiree Shareholders, Percent</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business Acquisition Contingent Consideration Potential Cash Payment Additions</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Business acquisition contingent consideration, potential cash payment at end of period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ContingentLiabilityRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Contingent Liability [Roll Forward]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ContingentLiabilityRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_PaymentsToContingentValueRightHolders">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Payments to contingent value right holders</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_PaymentsToContingentValueRightHolders</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_RevenueRoyaltytoAcquireeShareholdersPercent">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Revenue Royalty to Acquiree Shareholders, Percent</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_RevenueRoyaltytoAcquireeShareholdersPercent</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold Revenue Amount to Trigger Additional Royalty Payments</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Threshold Revenue Amount to Trigger Royalty Payments</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CydexPharmaceuticalsIncMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CydexPharmaceuticalsIncMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_MetabasisTherapeuticsMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_BusinessAcquisitionAxis=lgnd_CrystalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>66
<FILENAME>R51.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6813810224">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Narrative (Details) - USD ($)<br></strong></div></th>
<th class="th" colspan="1"></th>
<th class="th" colspan="3">1 Months Ended</th>
<th class="th" colspan="1">2 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
<th class="th" colspan="1"></th>
</tr>
<tr>
<th class="th"><div>May 31, 2012</div></th>
<th class="th"><div>May 31, 2018</div></th>
<th class="th"><div>May 31, 2016</div></th>
<th class="th"><div>Sep. 30, 2015</div></th>
<th class="th"><div>Feb. 28, 2019</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
<th class="th"><div>Jan. 23, 2019</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CorporateShareRepurchaseAbstract', window );"><strong>Corporate Share Repurchase</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodShares', window );">Shares repurchased in period (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">260,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">782,248<span></span>
</td>
<td class="nump">14,000<span></span>
</td>
<td class="nump">40,500<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare', window );">Price per share of shares repurchased (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 191.14<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodValue', window );">Shares repurchased in period</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 127,481,000<span></span>
</td>
<td class="nump">$ 1,966,000<span></span>
</td>
<td class="nump">$ 3,901,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchaseProgramAuthorizedAmount1', window );">Stock repurchase program, authorized amount</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 200,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchaseProgramPeriodInForce1', window );">Stock repurchase program, period in force</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">3 years<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1', window );">Stock repurchase program, remaining authorized repurchase amount</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 125,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember', window );">Stock Options</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue', window );">Weighted-average grant date fair value per share of stock options (USD per share)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 66.71<span></span>
</td>
<td class="nump">$ 53.17<span></span>
</td>
<td class="nump">$ 46.53<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue', window );">Intrinsic value of options exercised</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 51,900,000<span></span>
</td>
<td class="nump">$ 13,300,000<span></span>
</td>
<td class="nump">$ 12,000,000.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions', window );">Cash received from options exercised</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">19,800,000<span></span>
</td>
<td class="nump">$ 4,700,000<span></span>
</td>
<td class="nump">$ 6,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions', window );">Unrecognized compensation cost</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 20,400,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1', window );">Weighted-average period in which cost is expected to be recognized</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">2 years 4 months 20 days<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AwardTypeAxis=us-gaap_RestrictedStockMember', window );">Restricted Stock</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1', window );">Weighted-average period in which cost is expected to be recognized</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">1 year 4 months 17 days<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions', window );">Unrecognized compensation cost, restricted stock</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 9,200,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PlanNameAxis=lgnd_TwoThousandTwoStockIncentivePlanMember', window );">2002 Stock Incentive Plan | Stock Options</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized', window );">Increase the number of shares under the 2002 Stock Incentive Plan (shares)</a></td>
<td class="nump">1,800,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">900,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant', window );">Shares available for future option grants (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">600,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_PlanNameAxis=lgnd_AmendedESPPMember', window );">Amended ESPP</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant', window );">Shares available for future option grants (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">64,008<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_EmployeeStockPurchasePlanAbstract', window );"><strong>Employee Stock Purchase Plan</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee', window );">Shares allowed to purchase in employee stock purchase plan per employee (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,250<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod', window );">Common stock issued under amended ESSP (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,386<span></span>
</td>
<td class="nump">3,061<span></span>
</td>
<td class="nump">1,961<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember', window );">Subsequent Event</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_CorporateShareRepurchaseAbstract', window );"><strong>Corporate Share Repurchase</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchasedDuringPeriodShares', window );">Shares repurchased in period (shares)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">400,177<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockRepurchaseProgramAuthorizedAmount1', window );">Stock repurchase program, authorized amount</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 225,900,000<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 350,000,000.0<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_CorporateShareRepurchaseAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Corporate Share Repurchase [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_CorporateShareRepurchaseAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_EmployeeStockPurchasePlanAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Employee Stock Purchase Plan [Abstract]</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_EmployeeStockPurchasePlanAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Final price paid per share for the purchase of the targeted number of shares, determined by an average market price over a fixed period of time.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 30<br> -Section 25<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=6405686&amp;loc=d3e22802-112653<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (i)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Unrecognized cost of unvested share-based awards, other than options, awarded to employees as compensation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (i)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Unrecognized cost of unvested options awarded to employees as compensation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (i)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of cash inflow from issuance of shares under share-based compensation arrangement. Issuance includes, but is not limited to, exercise of stock options and similar instruments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=SL79508275-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 14<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3255-108585<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The highest quantity of shares an employee can purchase under the plan per period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of additional shares authorized for issuance under an established share-based compensation plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (d)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (d)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of share instruments newly issued under a share-based compensation plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchaseProgramAuthorizedAmount1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of stock repurchase plan authorized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchaseProgramAuthorizedAmount1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchaseProgramPeriodInForce1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Period which shares may be purchased under a stock repurchase plan authorized by an entity's Board of Directors, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchaseProgramPeriodInForce1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount remaining of a stock repurchase plan authorized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchasedDuringPeriodShares">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of shares that have been repurchased during the period and have not been retired and are not held in treasury. Some state laws may govern the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchasedDuringPeriodShares</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockRepurchasedDuringPeriodValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Equity impact of the value of stock that has been repurchased during the period and has not been retired and is not held in treasury. Some state laws may mandate the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockRepurchasedDuringPeriodValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AwardTypeAxis=us-gaap_EmployeeStockOptionMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AwardTypeAxis=us-gaap_RestrictedStockMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AwardTypeAxis=us-gaap_RestrictedStockMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PlanNameAxis=lgnd_TwoThousandTwoStockIncentivePlanMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PlanNameAxis=lgnd_TwoThousandTwoStockIncentivePlanMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_PlanNameAxis=lgnd_AmendedESPPMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_PlanNameAxis=lgnd_AmendedESPPMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>67
<FILENAME>R52.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6715482528">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Share-Based Compensation (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax', window );">Share-based compensation expense</a></td>
<td class="nump">$ 20,846<span></span>
</td>
<td class="nump">$ 24,915<span></span>
</td>
<td class="nump">$ 18,893<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeStatementLocationAxis=us-gaap_ResearchAndDevelopmentExpenseMember', window );">Research and development expenses</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax', window );">Share-based compensation expense</a></td>
<td class="nump">8,352<span></span>
</td>
<td class="nump">14,235<span></span>
</td>
<td class="nump">8,836<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeStatementLocationAxis=us-gaap_GeneralAndAdministrativeExpenseMember', window );">General and administrative expenses</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax', window );">Share-based compensation expense</a></td>
<td class="nump">$ 12,494<span></span>
</td>
<td class="nump">$ 10,680<span></span>
</td>
<td class="nump">$ 10,057<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeStatementLocationAxis=us-gaap_ResearchAndDevelopmentExpenseMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeStatementLocationAxis=us-gaap_ResearchAndDevelopmentExpenseMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeStatementLocationAxis=us-gaap_GeneralAndAdministrativeExpenseMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeStatementLocationAxis=us-gaap_GeneralAndAdministrativeExpenseMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>68
<FILENAME>R53.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6886353472">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Stock Option Plan Activity (Details) - USD ($)<br> $ / shares in Units, $ in Thousands</strong></div></th>
<th class="th" colspan="2">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward', window );"><strong>Shares [Rollforward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber', window );">Balance at beginning of period (shares)</a></td>
<td class="nump">1,876,332<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross', window );">Granted (shares)</a></td>
<td class="nump">228,362<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised', window );">Exercised (shares)</a></td>
<td class="num">(358,162)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod', window );">Forfeited (shares)</a></td>
<td class="num">(10,228)<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber', window );">Balance at end of period (shares)</a></td>
<td class="nump">1,736,304<span></span>
</td>
<td class="nump">1,876,332<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber', window );">Exercisable at end of period (shares)</a></td>
<td class="nump">1,313,374<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber', window );">Options vested and expected to vest at end of period (shares)</a></td>
<td class="nump">1,734,304<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward', window );"><strong>Weighted Average Exercise Price [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice', window );">Balance at beginning of period (USD per share)</a></td>
<td class="nump">$ 53.17<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice', window );">Granted (USD per share)</a></td>
<td class="nump">162.00<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice', window );">Exercised (USD per share)</a></td>
<td class="nump">55.24<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice', window );">Forfeited (USD per share)</a></td>
<td class="nump">114.53<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice', window );">Balance at end of period (USD per share)</a></td>
<td class="nump">66.71<span></span>
</td>
<td class="nump">$ 53.17<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice', window );">Exercisable at end of period (USD per share)</a></td>
<td class="nump">47.03<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice', window );">Options vested and expected to vest at end of period (USD per share)</a></td>
<td class="nump">$ 66.71<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2', window );">Weighted Average Remaining Contractual Term in Years</a></td>
<td class="text">5 years 5 months 19 days<span></span>
</td>
<td class="text">5 years 9 months 7 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1', window );">Exercisable, Weighted Average Remaining Contractual Term in Years</a></td>
<td class="text">4 years 6 months 21 days<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1', window );">Options vested and expected to vest, Weighted Average Remaining Contractual Term in Years</a></td>
<td class="text">5 years 5 months 19 days<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue', window );">Aggregate Intrinsic Value</a></td>
<td class="nump">$ 125,858<span></span>
</td>
<td class="nump">$ 157,340<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1', window );">Exercisable, Aggregate Intrinsic Value</a></td>
<td class="nump">117,314<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue', window );">Options vested and expected to vest, Aggregate Intrinsic Value</a></td>
<td class="nump">$ 125,858<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iv)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Gross number of share options (or share units) granted during the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of options outstanding, including both vested and non-vested options.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(i)-(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(i)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average price at which option holders acquired shares when converting their stock options into shares.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of share options (or share units) exercised during the current period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iv)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.3-04)<br> -URI http://asc.fasb.org/extlink&amp;oid=27012166&amp;loc=d3e187085-122770<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(28))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(29))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 505<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109259400&amp;loc=d3e21463-112644<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>69
<FILENAME>R54.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6813517520">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Breakdown of Options Outstanding (Details)<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th">
<div>Dec. 31, 2018 </div>
<div>$ / shares </div>
<div>shares</div>
</th></tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeElevenMember', window );">$8.58 &#8211; $195.91</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">$ 8.58<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 195.91<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">1,734,304<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">5 years 5 months 19 days<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 66.71<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">1,313,374<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 47.03<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeOneMember', window );">$8.58 - $10.05</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">8.58<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 10.05<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">184,702<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">1 year 10 months 13 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 10.00<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">184,702<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 10.00<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTwoMember', window );">$10.12 - $12.81</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">10.12<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 12.81<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">46,510<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">2 years 11 months 1 day<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 11.40<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">46,510<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 11.40<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeThreeMember', window );">$14.47 - $14.47</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">14.47<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 14.47<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">217,616<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">3 years 1 month 9 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 14.47<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">203,616<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 14.47<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFourMember', window );">$16.14 - $17.88</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">16.14<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 17.88<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">38,790<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">2 months 1 day<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 16.36<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">38,790<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 16.36<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFiveMember', window );">$21.92 - $21.92</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">21.92<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 21.92<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">200,372<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">4 years 1 month 17 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 21.92<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">200,372<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 21.92<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSixMember', window );">$32.00 - $56.26</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">32.00<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 56.26<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">182,767<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">5 years 8 months 12 days<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 50.38<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">174,470<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 50.10<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSevenMember', window );">$63.58 - $67.53</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">63.58<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 67.53<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">20,434<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">5 years 5 months 8 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 67.42<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">20,153<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 67.47<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeNineMember', window );">$74.42 - $74.42</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">74.42<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 74.42<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">190,825<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">5 years 1 month 13 days<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 74.42<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">190,825<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 74.42<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTenMember', window );">$85.79 - $100.38</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">85.79<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 100.38<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">299,282<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">7 years 6 months 25 days<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 93.32<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">157,872<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 91.62<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeEightMember', window );">$101.15 - $195.91</a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit', window );">Lower range of exercise prices (USD per share)</a></td>
<td class="nump">101.15<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit', window );">Upper range of exercise prices (USD per share)</a></td>
<td class="nump">$ 195.91<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions', window );">Options outstanding (shares) | shares</a></td>
<td class="nump">353,006<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2', window );">Weighted average remaining life in years</a></td>
<td class="text">8 years 9 months 14 days<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 148.50<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions', window );">Options exercisable (shares) | shares</a></td>
<td class="nump">96,064<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1', window );">Weighted average exercise price (USD per share)</a></td>
<td class="nump">$ 131.77<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (g)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(iii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(i)-(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The ceiling of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (g)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(i)-(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (e)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeElevenMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeElevenMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeOneMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeOneMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTwoMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTwoMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeThreeMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeThreeMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFourMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFourMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFiveMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeFiveMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSixMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSixMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSevenMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeSevenMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeNineMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeNineMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTenMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeTenMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeEightMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis=lgnd_ExercisePriceRangeEightMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>70
<FILENAME>R55.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6816543632">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Assumptions (Details)<br></strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MinimumMember', window );">Minimum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate', window );">Risk-free interest rate (as a percent)</a></td>
<td class="nump">2.70%<span></span>
</td>
<td class="nump">2.00%<span></span>
</td>
<td class="nump">1.30%<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate', window );">Expected volatility (as a percent)</a></td>
<td class="nump">33.00%<span></span>
</td>
<td class="nump">43.00%<span></span>
</td>
<td class="nump">48.00%<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1', window );">Expected term</a></td>
<td class="text">5 years 1 month 6 days<span></span>
</td>
<td class="text">6 years 6 months<span></span>
</td>
<td class="text">6 years 7 months 6 days<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_srt_RangeAxis=srt_MaximumMember', window );">Maximum</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems', window );"><strong>Share-based Compensation Arrangement by Share-based Payment Award [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate', window );">Risk-free interest rate (as a percent)</a></td>
<td class="nump">3.00%<span></span>
</td>
<td class="nump">2.20%<span></span>
</td>
<td class="nump">1.90%<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate', window );">Expected volatility (as a percent)</a></td>
<td class="nump">36.00%<span></span>
</td>
<td class="nump">47.00%<span></span>
</td>
<td class="nump">50.00%<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1', window );">Expected term</a></td>
<td class="text">5 years 9 months 18 days<span></span>
</td>
<td class="text">6 years 9 months 18 days<span></span>
</td>
<td class="text">6 years 8 months 12 days<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (f)(2)(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The risk-free interest rate assumption that is used in valuing an option on its own shares.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (f)(2)(iv)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:percentItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (f)(2)(i)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 14.D.2)<br> -URI http://asc.fasb.org/extlink&amp;oid=115993241&amp;loc=d3e301413-122809<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:durationItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MinimumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MinimumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_srt_RangeAxis=srt_MaximumMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">srt_RangeAxis=srt_MaximumMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>71
<FILENAME>R56.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6908272912">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Stockholders' Equity - Restricted Stock Activity (Details) - Restricted Stock<br></strong></div></th>
<th class="th" colspan="1">12 Months Ended</th>
</tr>
<tr><th class="th">
<div>Dec. 31, 2018 </div>
<div>$ / shares </div>
<div>shares</div>
</th></tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward', window );"><strong>Shares [Rollforward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber', window );">Outstanding at beginning of period (shares) | shares</a></td>
<td class="nump">133,294<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod', window );">Granted (shares) | shares</a></td>
<td class="nump">62,133<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod', window );">Vested (shares) | shares</a></td>
<td class="num">(61,989)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod', window );">Forfeited (shares) | shares</a></td>
<td class="num">(1,165)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber', window );">Outstanding at end of period (shares) | shares</a></td>
<td class="nump">132,273<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward', window );"><strong>Weighted-Average Grant Date Fair Value [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue', window );">Outstanding at beginning of period (USD per share) | $ / shares</a></td>
<td class="nump">$ 91.60<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue', window );">Granted (USD per share) | $ / shares</a></td>
<td class="nump">169.92<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue', window );">Vested (USD per share) | $ / shares</a></td>
<td class="nump">86.19<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue', window );">Forfeited (USD per share) | $ / shares</a></td>
<td class="nump">125.16<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue', window );">Outstanding at end of period (USD per share) | $ / shares</a></td>
<td class="nump">$ 130.63<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(1)(iv)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Weighted average fair value as of the grant date of equity-based award plans other than stock (unit) option plans that were not exercised or put into effect as a result of the occurrence of a terminating event.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(iii)(3)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(iii)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(iii)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(i)-(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(i)-(ii)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(iii)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The weighted average fair value as of grant date pertaining to an equity-based award plan other than a stock (or unit) option plan for which the grantee gained the right during the reporting period, by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash in accordance with the terms of the arrangement.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 718<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)(2)(iii)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=109197908&amp;loc=d3e5070-113901<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AwardTypeAxis=us-gaap_RestrictedStockMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AwardTypeAxis=us-gaap_RestrictedStockMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>72
<FILENAME>R57.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6885611136">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes - Narrative (Details) - USD ($)<br> $ in Millions</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwardsLineItems', window );"><strong>Operating Loss Carryforwards [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit', window );">Income tax expense (benefit) from the Tax Act</a></td>
<td class="nump">$ 0.6<span></span>
</td>
<td class="nump">$ 32.4<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount', window );">Valuation allowance, change in amount</a></td>
<td class="num">(2.5)<span></span>
</td>
<td class="num">$ (8.4)<span></span>
</td>
<td class="nump">$ 6.3<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate', window );">Unrecognized tax benefits that would impact effective tax rate</a></td>
<td class="nump">28.2<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_TaxCreditCarryforwardAxis=us-gaap_ResearchMember', window );">Research Tax Credit Carryforward</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwardsLineItems', window );"><strong>Operating Loss Carryforwards [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_TaxCreditCarryforwardAmount', window );">Tax credit carryforward</a></td>
<td class="nump">23.0<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_TaxCreditCarryforwardAxis=lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember', window );">California and New Jersey Research Tax Credit Carryforward</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwardsLineItems', window );"><strong>Operating Loss Carryforwards [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_TaxCreditCarryforwardAmount', window );">Tax credit carryforward</a></td>
<td class="nump">22.7<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxAuthorityAxis=us-gaap_InternalRevenueServiceIRSMember', window );">Internal Revenue Service (IRS)</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwardsLineItems', window );"><strong>Operating Loss Carryforwards [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwards', window );">Operating loss carryforward</a></td>
<td class="nump">229.9<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxAuthorityAxis=us-gaap_StateAndLocalJurisdictionMember', window );">State and Local Jurisdiction</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwardsLineItems', window );"><strong>Operating Loss Carryforwards [Line Items]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingLossCarryforwards', window );">Operating loss carryforward</a></td>
<td class="nump">$ 125.3<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Tax Cuts and Jobs Act of 2017, Income Tax Expense (Benefit)</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingLossCarryforwards">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32559-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingLossCarryforwards</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingLossCarryforwardsLineItems">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingLossCarryforwardsLineItems</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_TaxCreditCarryforwardAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32559-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_TaxCreditCarryforwardAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The total amount of unrecognized tax benefits that, if recognized, would affect the effective tax rate.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e32123-109318<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_TaxCreditCarryforwardAxis=us-gaap_ResearchMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_TaxCreditCarryforwardAxis=us-gaap_ResearchMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_TaxCreditCarryforwardAxis=lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_TaxCreditCarryforwardAxis=lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxAuthorityAxis=us-gaap_InternalRevenueServiceIRSMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxAuthorityAxis=us-gaap_InternalRevenueServiceIRSMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxAuthorityAxis=us-gaap_StateAndLocalJurisdictionMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxAuthorityAxis=us-gaap_StateAndLocalJurisdictionMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>73
<FILENAME>R58.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6813277792">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes - Components of Income Tax Expense (Benefit) (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Sep. 30, 2018</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Sep. 30, 2017</div></th>
<th class="th"><div>Jun. 30, 2017</div></th>
<th class="th"><div>Mar. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract', window );"><strong>Current expense (benefit):</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CurrentFederalTaxExpenseBenefit', window );">Federal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="nump">$ 0<span></span>
</td>
<td class="nump">$ 21<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CurrentStateAndLocalTaxExpenseBenefit', window );">State</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">424<span></span>
</td>
<td class="nump">111<span></span>
</td>
<td class="nump">12<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CurrentForeignTaxExpenseBenefit', window );">Foreign</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(158)<span></span>
</td>
<td class="nump">261<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CurrentIncomeTaxExpenseBenefit', window );">Total Current Income Tax Benefit</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">266<span></span>
</td>
<td class="nump">372<span></span>
</td>
<td class="nump">33<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract', window );"><strong>Deferred expense (benefit):</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredFederalIncomeTaxExpenseBenefit', window );">Federal</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">29,928<span></span>
</td>
<td class="nump">44,075<span></span>
</td>
<td class="nump">10,534<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit', window );">State</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(185)<span></span>
</td>
<td class="nump">228<span></span>
</td>
<td class="num">(240)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredForeignIncomeTaxExpenseBenefit', window );">Foreign</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxExpenseBenefit', window );">Income tax expense from continuing operations</a></td>
<td class="nump">$ 37,674<span></span>
</td>
<td class="nump">$ 3,645<span></span>
</td>
<td class="nump">$ 2,242<span></span>
</td>
<td class="nump">$ 1,114<span></span>
</td>
<td class="num">$ (14,307)<span></span>
</td>
<td class="nump">$ 11,864<span></span>
</td>
<td class="nump">$ 22,419<span></span>
</td>
<td class="nump">$ 10,033<span></span>
</td>
<td class="nump">$ 30,009<span></span>
</td>
<td class="nump">$ 44,675<span></span>
</td>
<td class="nump">$ 10,327<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CurrentFederalTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current federal tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CurrentFederalTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CurrentForeignTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current foreign income tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08.(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CurrentForeignTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CurrentIncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current income tax expense (benefit) pertaining to taxable income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CurrentIncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CurrentStateAndLocalTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current state and local tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CurrentStateAndLocalTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredFederalIncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred federal income tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredFederalIncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredForeignIncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred foreign income tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredForeignIncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred state and local tax expense (benefit) pertaining to income (loss) from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SAB Topic 6.I.7)<br> -URI http://asc.fasb.org/extlink&amp;oid=34349781&amp;loc=d3e330036-122817<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 9<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32639-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (h)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>74
<FILENAME>R59.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6818256240">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Sep. 30, 2018</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Sep. 30, 2017</div></th>
<th class="th"><div>Jun. 30, 2017</div></th>
<th class="th"><div>Mar. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract', window );"><strong>Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate', window );">Tax at federal statutory rate</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">$ 36,400<span></span>
</td>
<td class="nump">$ 20,031<span></span>
</td>
<td class="nump">$ 2,786<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes', window );">State, net of federal benefit</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,635<span></span>
</td>
<td class="nump">622<span></span>
</td>
<td class="nump">175<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncomeTaxReconciliationContingentValueRights', window );">Contingent liabilities</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">948<span></span>
</td>
<td class="nump">903<span></span>
</td>
<td class="nump">1,225<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost', window );">Stock-based compensation</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(8,131)<span></span>
</td>
<td class="num">(4,019)<span></span>
</td>
<td class="nump">263<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch', window );">Research and development credits</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(2,758)<span></span>
</td>
<td class="num">(2,821)<span></span>
</td>
<td class="num">(1,525)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions', window );">Change in uncertain tax positions</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">858<span></span>
</td>
<td class="nump">1,308<span></span>
</td>
<td class="nump">1,423<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate', window );">Rate change for changes in federal or state law</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">178<span></span>
</td>
<td class="nump">32,429<span></span>
</td>
<td class="nump">25<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance', window );">Change in valuation allowance</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="num">(4,225)<span></span>
</td>
<td class="num">(4,169)<span></span>
</td>
<td class="nump">6,283<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationTaxCreditsOther', window );">Expired NOLs and credits</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">3,054<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives', window );">Change in derivatives</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">615<span></span>
</td>
<td class="nump">0<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxReconciliationOtherAdjustments', window );">Other</a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="nump">1,435<span></span>
</td>
<td class="nump">391<span></span>
</td>
<td class="num">(328)<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxExpenseBenefit', window );">Income tax expense from continuing operations</a></td>
<td class="nump">$ 37,674<span></span>
</td>
<td class="nump">$ 3,645<span></span>
</td>
<td class="nump">$ 2,242<span></span>
</td>
<td class="nump">$ 1,114<span></span>
</td>
<td class="num">$ (14,307)<span></span>
</td>
<td class="nump">$ 11,864<span></span>
</td>
<td class="nump">$ 22,419<span></span>
</td>
<td class="nump">$ 10,033<span></span>
</td>
<td class="nump">$ 30,009<span></span>
</td>
<td class="nump">$ 44,675<span></span>
</td>
<td class="nump">$ 10,327<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Effective Income Tax Rate Reconciliation, Change in Derivatives</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Income Tax Reconciliation, Change in Uncertain Tax Positions</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncomeTaxReconciliationContingentValueRights">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Income Tax Reconciliation, Contingent Value Rights</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncomeTaxReconciliationContingentValueRights</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Income Tax Reconciliation, Expired Tax Credits, Research</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (h)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e32123-109318<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations, attributable to increase (decrease) in the income tax rates.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 15<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=d3e32059-109318<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to nondeductible equity-based compensation costs.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationOtherAdjustments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationOtherAdjustments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to state and local income tax expense (benefit).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxReconciliationTaxCreditsOther">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other tax credits.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 13<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32698-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 12<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32687-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxReconciliationTaxCreditsOther</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>75
<FILENAME>R60.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6814481024">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Income Taxes - Deferred Taxes (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsGrossAbstract', window );"><strong>Deferred assets:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards', window );">Net operating loss carryforwards</a></td>
<td class="nump">$ 57,181<span></span>
</td>
<td class="nump">$ 90,272<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards', window );">Research credit carryforwards</a></td>
<td class="nump">31,101<span></span>
</td>
<td class="nump">30,677<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets', window );">Fixed assets and intangibles</a></td>
<td class="nump">1,637<span></span>
</td>
<td class="nump">1,984<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities', window );">Accrued expenses</a></td>
<td class="nump">657<span></span>
</td>
<td class="nump">845<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsDeferredIncome', window );">Deferred revenue</a></td>
<td class="nump">957<span></span>
</td>
<td class="nump">17<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards', window );">Capital Loss Carryforward</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">1,609<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsEquityMethodInvestments', window );">Investment in Viking</a></td>
<td class="nump">0<span></span>
</td>
<td class="nump">5,137<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsOther', window );">Other</a></td>
<td class="nump">11,430<span></span>
</td>
<td class="nump">12,499<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsGross', window );">Deferred tax assets</a></td>
<td class="nump">102,963<span></span>
</td>
<td class="nump">143,040<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsValuationAllowance', window );">Valuation allowance for deferred tax assets</a></td>
<td class="num">(4,476)<span></span>
</td>
<td class="num">(6,987)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsNet', window );">Net deferred tax assets</a></td>
<td class="nump">98,487<span></span>
</td>
<td class="nump">136,053<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxLiabilitiesAbstract', window );"><strong>Deferred tax liabilities:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DeferredTaxLiabilitiesFairValueAdjustment', window );">Retrophin fair value adjustment</a></td>
<td class="num">(179)<span></span>
</td>
<td class="num">(243)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxLiabilitiesFinancingArrangements', window );">Convertible debt</a></td>
<td class="num">(2,905)<span></span>
</td>
<td class="num">(737)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets', window );">Identified intangibles</a></td>
<td class="num">(44,643)<span></span>
</td>
<td class="num">(48,237)<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets', window );">Identified indefinite lived intangibles</a></td>
<td class="num">(1,759)<span></span>
</td>
<td class="num">(2,414)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxLiabilitiesInvestments', window );">Investment in Viking</a></td>
<td class="num">(2,480)<span></span>
</td>
<td class="nump">0<span></span>
</td>
</tr>
<tr class="reu">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredIncomeTaxLiabilities', window );">Net deferred tax liabilities</a></td>
<td class="num">(51,966)<span></span>
</td>
<td class="num">(51,631)<span></span>
</td>
</tr>
<tr class="rou">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_DeferredTaxAssetsLiabilitiesNet', window );">Total</a></td>
<td class="nump">$ 46,521<span></span>
</td>
<td class="nump">$ 84,422<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Deferred Tax Assets, Property, Plant and Equipment and Intangible Assets</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DeferredTaxLiabilitiesFairValueAdjustment">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Deferred Tax Liabilities, Fair Value Adjustment</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DeferredTaxLiabilitiesFairValueAdjustment</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Deferred Tax Liabilities, Finite-Lived Intangible Assets</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Deferred Tax Liabilities, Indefinite-Lived Intangible Assets</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>lgnd_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredIncomeTaxLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred tax liability attributable to taxable temporary differences.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(26)(b))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-03(15)(b)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=6879938&amp;loc=d3e572229-122910<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 210<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-03(15)(2))<br> -URI http://asc.fasb.org/extlink&amp;oid=6876686&amp;loc=d3e534808-122878<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 210<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.5-02(26)(a))<br> -URI http://asc.fasb.org/extlink&amp;oid=6877327&amp;loc=d3e13212-122682<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredIncomeTaxLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsCapitalLossCarryforwards">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible capital loss carryforwards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsCapitalLossCarryforwards</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsDeferredIncome">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from deferred income.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsDeferredIncome</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsEquityMethodInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from equity method investments.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsEquityMethodInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsGross">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsGross</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsGrossAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsGrossAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsLiabilitiesNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsLiabilitiesNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsNet">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (b),(c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsNet</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsOperatingLossCarryforwards">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsOperatingLossCarryforwards</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsOther">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsOther</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsTaxCreditCarryforwards">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 3<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32559-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsTaxCreditCarryforwards</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -Subparagraph (b)<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxAssetsValuationAllowance">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 2<br> -Subparagraph (c)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32537-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxAssetsValuationAllowance</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxLiabilitiesAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxLiabilitiesAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxLiabilitiesFinancingArrangements">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred tax liability attributable to taxable temporary differences from financing arrangements.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 6<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32621-109319<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 25<br> -Paragraph 20<br> -URI http://asc.fasb.org/extlink&amp;oid=115928272&amp;loc=d3e28680-109314<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 8<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=d3e32632-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxLiabilitiesFinancingArrangements</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_DeferredTaxLiabilitiesInvestments">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of deferred tax liability attributable to taxable temporary differences from investments (excludes investments in subsidiaries and equity method investments).</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_DeferredTaxLiabilitiesInvestments</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>76
<FILENAME>R61.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6885246480">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details) - USD ($)<br> $ in Thousands</strong></div></th>
<th class="th" colspan="3">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward', window );"><strong>Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefits', window );">Balance at beginning of period</a></td>
<td class="nump">$ 29,363<span></span>
</td>
<td class="nump">$ 38,770<span></span>
</td>
<td class="nump">$ 36,452<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions', window );">Additions based on tax positions related to the current year</a></td>
<td class="nump">1,247<span></span>
</td>
<td class="nump">1,067<span></span>
</td>
<td class="nump">70<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions', window );">Additions for tax positions of prior years</a></td>
<td class="nump">336<span></span>
</td>
<td class="nump">109<span></span>
</td>
<td class="nump">2,408<span></span>
</td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions', window );">Reductions for tax positions of prior years</a></td>
<td class="num">(657)<span></span>
</td>
<td class="num">(10,583)<span></span>
</td>
<td class="num">(160)<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_UnrecognizedTaxBenefits', window );">Balance at end of period</a></td>
<td class="nump">$ 30,289<span></span>
</td>
<td class="nump">$ 29,363<span></span>
</td>
<td class="nump">$ 38,770<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrecognizedTaxBenefits">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of unrecognized tax benefits.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10B<br> -URI http://asc.fasb.org/extlink&amp;oid=84176650&amp;loc=SL37586934-109318<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrecognizedTaxBenefits</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of decrease in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase in unrecognized tax benefits resulting from tax positions that have been or will be taken in current period tax return.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -Subparagraph (a)(2)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of increase in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 10<br> -Section 50<br> -Paragraph 15A<br> -Subparagraph (a)(1)<br> -URI http://asc.fasb.org/extlink&amp;oid=84230637&amp;loc=SL6600010-109319<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>77
<FILENAME>R62.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6671235840">
<tr>
<th class="tl" colspan="1" rowspan="2"><div style="width: 200px;"><strong>Summary of Unaudited Quarterly Financial Information - Summary (Details) - USD ($)<br> $ / shares in Units, shares in Thousands, $ in Thousands</strong></div></th>
<th class="th" colspan="8">3 Months Ended</th>
<th class="th" colspan="6">12 Months Ended</th>
</tr>
<tr>
<th class="th"><div>Dec. 31, 2018</div></th>
<th class="th"><div>Sep. 30, 2018</div></th>
<th class="th"><div>Jun. 30, 2018</div></th>
<th class="th"><div>Mar. 31, 2018</div></th>
<th class="th"><div>Dec. 31, 2017</div></th>
<th class="th"><div>Sep. 30, 2017</div></th>
<th class="th"><div>Jun. 30, 2017</div></th>
<th class="th"><div>Mar. 31, 2017</div></th>
<th class="th" colspan="2"><div>Dec. 31, 2018</div></th>
<th class="th" colspan="2"><div>Dec. 31, 2017</div></th>
<th class="th" colspan="2"><div>Dec. 31, 2016</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract', window );"><strong>Quarterly Financial Information Disclosure [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax', window );">Total revenues</a></td>
<td class="nump">$ 50,465<span></span>
</td>
<td class="nump">$ 33,375<span></span>
</td>
<td class="nump">$ 27,995<span></span>
</td>
<td class="nump">$ 29,267<span></span>
</td>
<td class="nump">$ 59,590<span></span>
</td>
<td class="nump">$ 45,663<span></span>
</td>
<td class="nump">$ 90,043<span></span>
</td>
<td class="nump">$ 56,157<span></span>
</td>
<td class="nump">$ 251,453<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 141,102<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 108,973<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_OperatingCostsAndExpenses', window );">Total operating costs and expenses</a></td>
<td class="nump">22,113<span></span>
</td>
<td class="nump">16,882<span></span>
</td>
<td class="nump">14,980<span></span>
</td>
<td class="nump">19,051<span></span>
</td>
<td class="nump">26,441<span></span>
</td>
<td class="nump">22,301<span></span>
</td>
<td class="nump">19,868<span></span>
</td>
<td class="nump">19,116<span></span>
</td>
<td class="nump">87,726<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">73,026<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">65,088<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_IncomeTaxExpenseBenefit', window );">Income tax (expense) benefit</a></td>
<td class="num">(37,674)<span></span>
</td>
<td class="num">(3,645)<span></span>
</td>
<td class="num">(2,242)<span></span>
</td>
<td class="num">(1,114)<span></span>
</td>
<td class="nump">14,307<span></span>
</td>
<td class="num">(11,864)<span></span>
</td>
<td class="num">(22,419)<span></span>
</td>
<td class="num">(10,033)<span></span>
</td>
<td class="num">(30,009)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(44,675)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">(10,327)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_NetIncomeLoss', window );">Net Income (loss)</a></td>
<td class="num">$ (7,007)<span></span>
</td>
<td class="nump">$ 8,426<span></span>
</td>
<td class="nump">$ 6,058<span></span>
</td>
<td class="nump">$ 5,079<span></span>
</td>
<td class="num">$ (42,482)<span></span>
</td>
<td class="nump">$ 67,362<span></span>
</td>
<td class="nump">$ 73,160<span></span>
</td>
<td class="nump">$ 45,279<span></span>
</td>
<td class="nump">$ 143,321<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">$ 12,556<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="num">$ (1,636)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareBasicAbstract', window );"><strong>Basic per share amounts:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareBasic', window );">Net income (loss) - Basic (USD per share)</a></td>
<td class="num">$ (0.33)<span></span>
</td>
<td class="nump">$ 0.40<span></span>
</td>
<td class="nump">$ 0.29<span></span>
</td>
<td class="nump">$ 0.24<span></span>
</td>
<td class="num">$ (2.02)<span></span>
</td>
<td class="nump">$ 3.19<span></span>
</td>
<td class="nump">$ 3.45<span></span>
</td>
<td class="nump">$ 2.13<span></span>
</td>
<td class="nump">$ 6.77<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">$ 0.60<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="num">$ (0.08)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareDilutedAbstract', window );"><strong>Diluted per share amounts:</strong></a></td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_EarningsPerShareDiluted', window );">Net income (loss) - Diluted (USD per share)</a></td>
<td class="num">$ (0.33)<span></span>
</td>
<td class="nump">$ 0.36<span></span>
</td>
<td class="nump">$ 0.26<span></span>
</td>
<td class="nump">$ 0.22<span></span>
</td>
<td class="num">$ (2.02)<span></span>
</td>
<td class="nump">$ 2.80<span></span>
</td>
<td class="nump">$ 2.99<span></span>
</td>
<td class="nump">$ 1.83<span></span>
</td>
<td class="nump">$ 5.96<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="nump">$ 0.53<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
<td class="num">$ (0.08)<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"><sup>[1]</sup></td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic', window );">Weighted average shares&#8212;basic (shares)</a></td>
<td class="nump">21,109<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">21,013<span></span>
</td>
<td class="nump">20,938<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">21,148<span></span>
</td>
<td class="nump">21,212<span></span>
</td>
<td class="nump">21,209<span></span>
</td>
<td class="nump">21,160<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">21,032<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">20,831<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding', window );">Weighted average shares&#8212;diluted (shares)</a></td>
<td class="nump">21,109<span></span>
</td>
<td class="nump">23,551<span></span>
</td>
<td class="nump">23,216<span></span>
</td>
<td class="nump">23,019<span></span>
</td>
<td class="nump">21,071<span></span>
</td>
<td class="nump">24,052<span></span>
</td>
<td class="nump">24,438<span></span>
</td>
<td class="nump">24,800<span></span>
</td>
<td class="nump">24,067<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">23,481<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
<td class="nump">20,831<span></span>
</td>
<td class="fn" style="border-bottom: 0px;"></td>
</tr>
<tr><td colspan="15"></td></tr>
<tr><td colspan="15"><table class="outerFootnotes" width="100%"><tr class="outerFootnote">
<td style="vertical-align: top; width: 12pt;" valign="top">[1]</td>
<td style="vertical-align: top;" valign="top">The sum of net income per share amounts may not equal the total due to rounding</td>
</tr></table></td></tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareBasic">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 3: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 55<br> -Paragraph 52<br> -URI http://asc.fasb.org/extlink&amp;oid=109256448&amp;loc=d3e4984-109258<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 250<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=109234566&amp;loc=d3e22694-107794<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareBasic</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareBasicAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareBasicAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareDiluted">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/exampleRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 55<br> -Paragraph 52<br> -URI http://asc.fasb.org/extlink&amp;oid=109256448&amp;loc=d3e4984-109258<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 2<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1252-109256<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 4: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(23))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 5: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 250<br> -SubTopic 10<br> -Section 50<br> -Paragraph 11<br> -URI http://asc.fasb.org/extlink&amp;oid=109234566&amp;loc=d3e22694-107794<br><br>Reference 6: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 7<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1337-109256<br><br>Reference 7: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(21))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 8: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 60B<br> -Subparagraph (d)<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=SL5780133-109256<br><br>Reference 9: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(19))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareDiluted</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>num:perShareItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_EarningsPerShareDilutedAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_EarningsPerShareDilutedAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_IncomeTaxExpenseBenefit">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 280<br> -SubTopic 10<br> -Section 50<br> -Paragraph 22<br> -Subparagraph (h)<br> -URI http://asc.fasb.org/extlink&amp;oid=115929826&amp;loc=d3e8736-108599<br><br>Reference 2: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 235<br> -SubTopic 10<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.4-08(h))<br> -URI http://asc.fasb.org/extlink&amp;oid=26873400&amp;loc=d3e23780-122690<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 740<br> -SubTopic 20<br> -Section 45<br> -Paragraph 2<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109238882&amp;loc=d3e38679-109324<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_IncomeTaxExpenseBenefit</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_NetIncomeLoss">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1A<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669619-108580<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 942<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.9-04(22))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873765&amp;loc=SL114874048-224260<br><br>Reference 3: http://www.xbrl.org/2003/role/disclosureRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section 45<br> -Paragraph 1B<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=114867106&amp;loc=SL7669625-108580<br><br>Reference 4: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 944<br> -SubTopic 220<br> -Section S99<br> -Paragraph 1<br> -Subparagraph (SX 210.7-04(18))<br> -URI http://asc.fasb.org/extlink&amp;oid=114873790&amp;loc=SL114874131-224263<br><br>Reference 5: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 220<br> -SubTopic 10<br> -Section S99<br> -Paragraph 2<br> -Subparagraph (SX 210.5-03(20))<br> -URI http://asc.fasb.org/extlink&amp;oid=115205541&amp;loc=SL114868664-224227<br><br>Reference 6: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 230<br> -SubTopic 10<br> -Section 45<br> -Paragraph 28<br> -URI http://asc.fasb.org/extlink&amp;oid=109223946&amp;loc=d3e3602-108585<br><br>Reference 7: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_NetIncomeLoss</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_OperatingCostsAndExpenses">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Excludes Selling, General and Administrative Expense.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_OperatingCostsAndExpenses</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>debit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_QuarterlyFinancialInformationDisclosureAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- References</a><div><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_QuarterlyFinancialInformationDisclosureAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 4<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130543-203045<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130539-203045<br><br>Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 606<br> -SubTopic 10<br> -Section 50<br> -Paragraph 5<br> -URI http://asc.fasb.org/extlink&amp;oid=109196051&amp;loc=SL49130545-203045<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 16<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1505-109256<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 45<br> -Paragraph 10<br> -URI http://asc.fasb.org/extlink&amp;oid=109260490&amp;loc=d3e1448-109256<br><br>Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef<br> -Publisher FASB<br> -Name Accounting Standards Codification<br> -Topic 260<br> -SubTopic 10<br> -Section 50<br> -Paragraph 1<br> -Subparagraph (a)<br> -URI http://asc.fasb.org/extlink&amp;oid=6371337&amp;loc=d3e3550-109257<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_WeightedAverageNumberOfSharesOutstandingBasic</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:sharesItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>78
<FILENAME>R9999.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.10.0.1</span><table class="report" border="0" cellspacing="2" id="idp6716697760">
<tr>
<th class="tl" colspan="1">Label</th>
<th class="tl"><strong>Element</strong></th>
<th class="th" colspan="1">Value</th>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member', window );">Accounting Standards Update 2016-09 [Member] | Additional Paid-in Capital [Member]</a></td>
<td class="th" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative Effect of New Accounting Principle in Period of Adoption</a></td>
<td class="th" style="border-bottom: 0px;">us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption</td>
<td class="nump">$ 456,000<span></span>
</td>
</tr>
<tr class="rh">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member', window );">Accounting Standards Update 2016-01 [Member] | AOCI Attributable to Parent [Member]</a></td>
<td class="th" style="border-bottom: 0px;"></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption', window );">Cumulative Effect of New Accounting Principle in Period of Adoption</a></td>
<td class="th" style="border-bottom: 0px;">us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption</td>
<td class="num">$ (2,662,000)<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Amount after tax of increase (decrease) to equity or (increase) decrease to net assets, resulting from the cumulative effect adjustment of a new accounting principle applied in the period of adoption.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>us-gaap_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:monetaryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>credit</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>instant</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201609Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementEquityComponentsAxis=us-gaap_AdditionalPaidInCapitalMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementEquityComponentsAxis=us-gaap_AdditionalPaidInCapitalMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_AdjustmentsForNewAccountingPronouncementsAxis=us-gaap_AccountingStandardsUpdate201601Member</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_us-gaap_StatementEquityComponentsAxis=us-gaap_AccumulatedOtherComprehensiveIncomeMember">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Details</a><div><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">us-gaap_StatementEquityComponentsAxis=us-gaap_AccumulatedOtherComprehensiveIncomeMember</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td></td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td></td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EXCEL
<SEQUENCE>79
<FILENAME>Financial_Report.xlsx
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 Financial_Report.xlsx
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MMWF\81AU8\K(XK%T-8943OTJDH\ Q:X831F:3LTXXFBD(3^ G/,6+V2?$9/
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MZ+"C"+SDP)IIHC^-;0U7P 0C#"Y^%]#,Q%S]$YL[P,[),=HY-0Q#.2QR+NW
MX?WYZ36O6]@NDNHTIE_12CIY7+/+Y+?%P^-VPQI1\?NB$H6XV_*5%$O);S\F
MUQ]^5V'7&[NS_]CX(MC4\.LNFB]02P,$%     @ -(-<3IE<G",0!@  G"<
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M.AQG0GS/]O:1I24RS^_Y"NM./&<?5I:P7<_/Y)Z,<B.[W?98??9/1VXCUZG
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MKB\X":&YV4H\,SER,;WE,*GX2=OAW(QEUV!U$RW:OGF,A@YV\P]02P,$%
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M:*2>IFK.I[MA"B0;YFL/+7=O\0=02P,$%     @ -(-<3AE=B&G*!0  31X
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MUG0<%N.&DWZ:@]X\C/._4$L#!!0    ( #2#7$[NL+U\$@8  'T@   8
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M+*("NK[ \RP+0:3K*ZJ02<4L!I<%%94<I-)JV*BG4DM"(6O<^FQ#8[L86A9
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M"?Y7=[3HL9FEE!I:)TU++%09O4OVAUW(CPF_)0QN89/0R<F8Y^!\*S.Z"8)
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MO8A/O#_RT)LJ.E,KTET0[X+W6G*>Y>P:B>:8TQ3#5S'[)8(%]B4%WTIQXO_
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MT?F7C?VO$!UX*9LK/T*-_V"S(:%RX7CCSV8<L]%PV$T_B,W?./\+4$L#!!0
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MV/_:& ^82G*%(]3B!UL,!;4/Q\]XMM.8388W_?R#V/*-BW]02P,$%     @
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M6:>%@*OUTYV;ZZ&_# NKNK%UTJE_YW\ 4$L#!!0    ( #2#7$ZKV J([0$
M &8%   9    >&PO=V]R:W-H965T<R]S:&5E=#(V+GAM;'54VXZ;,!#]%<0'
MK D00B- VFQ5M5(K15NU?79@N&AM3&T3MG]?V["4TNE+;(_/9<9D)IN$?%$M
M@/9>.>M5[K=:#V="5-D"I^I!#-";FUI(3K4YRH:H00*M'(DS$@9!0CCM>K_(
M7.PJBTR,FG4]7*6G1LZI_'4!)J;</_AO@>>N:;4-D"(;: -?07\;KM*<R*I2
M=1QZU8G>DU#G_N/A?$DMW@&^=S"IS=ZSE=R$>+&'3U7N!S8A8%!JJT#-<H<G
M8,P*F31^+IK^:FF)V_V;^@=7NZGE1A4\"?:CJW2;^ZGO55#3D>EG,7V$I9ZC
M[RW%?X8[, .WF1B/4C#E?KUR5%KP1<6DPNGKO':]6Z?Y)HD6&DX(%T*X$E+G
M0V8CE_E[JFF123%Y<G[[@=I/?#B'YFU*&W1/X>Y,\LI$[T44)1FY6Z$%<YDQ
MX09S6!'$J*\6(69Q"?^AAS@]0C.,'#W:TJ,3+A"C K$3B/\J\;0K$<.DN,D1
M-3DB N]V)@@F#G"3!#5)$('#S@3#_.>]3ZC)"1&(=B88)L9-4M0D102..Q,,
MD^Q,R.9_SD$VKL.55XJQ=]-E$UV'R&/H^N0/?)Y 7ZALNEYY-Z%-M[F>J(70
M8%()'LRG:\W06P\,:FVW)[.7<^O/!RV&9:J1=;06OP%02P,$%     @ -(-<
M3@%!BTWB 0   04  !D   !X;"]W;W)K<VAE971S+W-H965T,C<N>&UL=53;
M;MP@$/T5Q <$KR_K[<JVE$T4M5(KK5*U?6;M\44!XP*[3O^^@!W7=<B+888S
MY\R,&;)1R!?5 FCTREFO<MQJ/1P)464+G*H[,4!O3FHA.=7&E U1@P1:N2#.
M2!@$>\)IU^,B<[ZS+#)QU:SKX2R1NG).Y9\3,#'F>(??',]=TVKK($4VT :^
M@_XQG*6QR,)2=1QZU8D>2:AS?+\[GE*+=X"?'8QJM4>VDHL0+];X4N4XL D!
M@U);!FJ6&SP 8Y;(I/%[YL2+I U<[]_8GUSMII8+5? @V*^NTFV.#QA54-,K
MT\]B_ QS/0E&<_%?X0;,P&TF1J,43+DO*J]*"SZSF%0X?9W6KG?K.)TDT1SF
M#PCG@' ).#@=,@FYS!^IID4FQ8CDU/N!VE^\.X:F-Z5UNE:X,Y.\,MY;$<5I
M1FZ6:,:<)DRXPNP6!#'LBT3HDSB%[\)#?WCDS3!RX=$Z/([\!+&7('8$\7\E
M'C8E^C"?_"*)5R1Y3Y $&Q$?YH-.[KTB>P]!N!'Q83YH5^H523T$\4;$ATDV
M(F1U!3G(Q@V?0J6X]F[P5]YEON]#=X7_P:?'X1N53=<K=!':#(*[KK40&DPJ
MP9WI:FO>H\5@4&N[3<U>3E,Y&5H,\X-#EE>O^ M02P,$%     @ -(-<3A1H
MT<JW 0  T@,  !D   !X;"]W;W)K<VAE971S+W-H965T,C@N>&UL;5/;;IPP
M$/T5RQ\0[[)DLUH!4C95E4JMM$K4]MD+ UCQA=AF2?\^8T,H37FQ/>-SSEP\
MS@9C7UP+X,F;DMKEM/6^.S+FRA84=S>F XTWM;&*>S1MPUQG@5>1I"1+-IL]
M4UQH6F31=[9%9GHOA8:S):Y7BML_)Y!FR.F6?CB>1-/ZX&!%UO$&GL'_[,X6
M+3:K5$*!=L)H8J'.Z?WV>$H#/@)^"1C<XDQ")1=C7H+QK<KI)B0$$DH?%#AN
M5W@ *8,0IO$Z:=(Y9" NSQ_J7V/M6,N%.W@P\K>H?)O3 R45U+R7_LD,CS#5
M<TO)5/QWN()$>,@$8Y1&NKB2LG?>J$D%4U'\;=R%COLPWNR3B;9.2"9",A,.
M,0X; \7,OW#/B\R:@=BQ]QT/3[P])MB;,CAC*^(=)N_0>RUVM_N,78/0A#F-
MF&2!V<X(ANISB&0MQ"GYCYZLTW>K&>XB?;>DI_MU@715((T"Z3\EWGTJ<0US
M^!2$+7JJP#9QFAPI3:_C)"^\\\#>QT=D?^'CM/_@MA':D8OQ^+*Q_[4Q'C"5
MS0V.4(L?;#8DU#X<[_!LQS$;#6^ZZ0>Q^1L7[U!+ P04    "  T@UQ.Y0L/
M,-$*  #510  &0   'AL+W=O<FMS:&5E=',O<VAE970R.2YX;6R57%M7VT@3
M_"L<WH/5<],,!S@GSMWKL&RR^?;9"4K@K(U9VPF[__Z3;1FLZ2IAO80@:BX]
MT]7=,RK[[&&^^'MY4U6KHW]GT[OE^?'-:G5_.A@LO]U4L\GR9'Y?W=5_^3Y?
MS":K^M?%C\'R?E%-KC>-9M.!*8HPF$UN[XXOSC;/KA879_.?J^GM776U.%K^
MG,TFB_^&U73^<'XLQ[L'GVY_W*S6#P879_>3']7G:O7E_FI1_S9X[.7Z=E;=
M+6_G=T>+ZOOY\4LY_2+.K5ML(/^[K1Z6>_\_6MOR=3[_>_W+A^OSXV(]I6I:
M?5NM^YC4/WY5KZKI=-U5/9%_FEZ/'P==-]S__Z[WMQOK:VN^3I;5J_GTK]OK
MU<WY<3P^NJZ^3WY.5Y_F#^^KQB)_?-28/ZY^5=,:OIY)/<:W^72Y^??HV\_E
M:CYK>JFG,IO\N_UY>[?Y^=#TOVN&&YBF@3FT@6T:V,<&5CH;N*:!.[2!;QKX
M0QN$ID$XM$'9-"@/;1";!O'0!JEID YM(,5NYXK')LYT-WG<[*?==MTM=KLM
MYN!Y[?9;[*&#[#9<#MYQV6VY^$,'V>VY/&VZ>:;);M?E:=O-,_/:[;O$@YOL
M=E[2H4W,;NO-T];7J]W99+?UYFGKZP'7,6@;(#81Y_5D-;DX6\P?CA;;J'D_
M60=G.:U;U9VOGVYBV.:/==19UD]_75B?S@:_UCTUF.$68_8QH6AC1AHCCXA!
M/87'>1@XCZ$!8TA[C%<(8]J8UPACVY@W"./:F+<(X]N8=P@3VICW"%.V,1\0
M)F;KBS#9/HT/F/,EP)397EXA3+87?R!,MA>?$";;B\\(D^W%GPB3V?4%80+V
M0(N98#<]V%8/)>[!X1[<I@>WUX.1S-[1%E-N,'<;C(M%D>W 6*/JFD7!+C7L
MA4B1]H&M>7L\;Z_F;<O<_Q FX5$"'B7H'F(>18(R*%^9+<)#1&L6)9Y%"6:1
M^?:PU,MJ3))4JAUX"Z#U/B6C-VM4JIFS7L< JGMM61NQM1%8F[%T%-5@+A0%
M'2GAD1(8*??]I$:R1<=(ZTH(IJP"C)7%C%$#VA],NLP2EA]%#9:OX+#![(_E
M"Q>\VMA7#7+?7ZRM@YE"O@9(4Z:DD6\0,ID G!7-,_E4*.0[T*?S(5B%? ^0
M=8=.(S\ I _B]3Q'8)[&B_.ZTS& BJMCH-'!$D&+F$K+?0+7*B_%*)^0PN9.
M871HJ&W5YKX"R.A, #ZA@:'P.GV\ 4!?E EX!)BD,R[JY7N'!B_K^@NXA$:6
M=DN^W"4TTGD#)CH"2''6&@$N :#&>[V>E\AZ"39PAR"E@U@0D7SN$%M0VA^M
M.+$V]P8-JU$A=P6$,B'W X@RN1. B9F3PN0.H&'F).9[CT IY?NN47*BT@5
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MR/:7U?S^?/LE*H/';W*Y^#]02P,$%     @ -(-<3I=12J \ @  @0<  !D
M  !X;"]W;W)K<VAE971S+W-H965T,S N>&ULC57MCMHP$'R5* ]PSA<!3B'2
M :I:J9705;W^-F$AT=EQ:AMR??O:3LA!V+OR!]N;F?'N8'NS5LA750)H[XVS
M6BW\4NOFD1!5E,"I>A -U.;+7DA.M5G* U&-!+IS),Y(% 0IX;2J_3QSL8W,
M,W'4K*IA(SUUY)S*OTM@HEWXH7\./%>'4ML R;.&'N GZ%_-1IH5&51V%8=:
M5:+V).P7_E/XN X=P2%>*FC5Q=RSI6R%>+6+;[N%']B,@$&AK00UPPE6P)A5
M,GG\Z47]84]+O)R?U;^XXDTQ6ZI@)=CO:J?+A3_SO1WLZ9'I9]%^A;Z@B>_U
MU7^'$S #MYF8/0K!E/OUBJ/2@O<J)A5.W[JQJMW8]OIG&DZ(>D(T$,+T4T+<
M$^)W0O(I(>D)R8A NE*<-VNJ:9Y)T7JR^WL;:D]1^)@8]PL;=&:[;\8>9:*G
M/)E,,W*R0CUFV6&B"TPX((A1'[:(L"V6T0T]NMY@=8N(XVO(^A8R"_ D8K3.
MV/&3JSIGN$"""B1.(+X2F.,"$U1@<IM!&HR<QC#AR"P,,S)TC6%B/-D4339%
M!!)<8(H*3.^W:X8*S.ZP"\-,1G9AF'1D%X:9XLG.T63GB, 'IRL,\'L8W&]8
M^,%5#N^P# .%XR.&*LU'IOT'U&5,+MXA#O+@WGCE%>)8:WN=+Z)#'WF*[#LV
MBB]M?W'OV[M,UYQ^4'FH:N5MA3:OI'O+]D)H,#D&#^8BE*8?#@L&>VVG4S.7
M75/H%EHT?<,C0]?-_P%02P,$%     @ -(-<3M+-OD^  P  *@\  !D   !X
M;"]W;W)K<VAE971S+W-H965T,S$N>&ULE5?9<ILP%/T5A@\H$MI0QO9,G'1)
MXLYDVFG[3&S99@K(!1RW?U^QF&#IDI 7 _(Y1W?3E30[Z>)WN5>J\OYF:5[.
M_7U5':Z"H%SO51:7'_1!Y>:?K2ZRN#*?Q2XH#X6*-PTI2X,0(1YD<9+[BUDS
M]E@L9OI8I4FN'@NO/&997/Q;JE2?YC[VSP/?DMV^J@>"Q>P0[]1W5?TX/!;F
M*^A5-DFF\C+1N5>H[=R_QE<K+&M"@_B9J%,Y>/=J5YZT_EU_W&WF/JHM4JE:
M5[5$;![/ZD:E::UD[/C3B?K]G#5Q^'Y6_]0X;YQYBDMUH]-?R:;:S_W(]S9J
M&Q_3ZIL^?5&=0\SW.N]7ZEFE!EY;8N98Z[1L?KWUL:QTUJD84[+X;_M,\N9Y
MZO3/-)@0=H2P)YBY7R.0CD!>"/15 NT(="J!=00VE< [ I]*$!U!3"5$'2&:
M2I =04XE8'3.''JA\-<I?;+QY%G.Z<:A10G:PFHJ]3:NXL6LT">O:!?;(:[7
M-+XR+"->CS:UW_QIJK4TH\\+*M L>*Z5.LRRQ80##.$6YM[%X!X1&!-Z.T+0
MCF7H\,/+&6Y<!!7X$G,+8"X1'R$5:Z9/+H:02\AG2,;"?($PECEW$(99H7TS
M- ]O&[QR(1&"$T3@0B&- +FPE,,*%%:@C0(=FF YLFPAHH'D#80ARJV W+@H
M0H@=MEL7%0HI+=1' "5#+JR* .R23%IKX+.+HHQSNRQ<E$2(6J@[8$:.F677
M/6 ]PY198@\N#%.,D17]%0!#D1S4]466&9QEYF098P8K<%B!3Z\T 2N(-ROM
MOH6PB[SCT X<@ J1W1]7$(H-HGMA<@2;' %A&W%:P@IR>MCJO0G<#-#;@>LP
M0V\E$79C>P!@!!%J%? *@(4"T6C$[K%-##MV4R%&-. -Z!J'[XC?2(_$9$+\
MB..QB+#=EQX &";<;H4K"(:8&&GM>*0S8[<U4S&6@Y%UC]D[XC>R\C&?$#_N
M>,R9$';X7)1I>-+>%2$81W+DZ()'V@UV^PT5<D1C9/WCZ!WA&^D 6$X(GX2V
M'_M  : 8BZ0=/1=%(GO9!8.C:*:*77/I*KVU/N95[>]@M+_878?U4=8:7^*K
M.PR,W]<7P>;H^R+?WB*_QL4NR4OO25?F"-V<<K=:5\K8CCZ8G._-Q;7_2-6V
MJE^%>2_:VUO[4>E#=S,-^NOQXC]02P,$%     @ -(-<3B.^YEQ6 @  ) @
M !D   !X;"]W;W)K<VAE971S+W-H965T,S(N>&ULE99OKYHP%,:_"N'];FGY
MJT&2Z;)LR9;<W&7;ZZI5R"V4M57OOOW:@D3@F.M\(6UYSM/?.<*I^47(5U4R
MIKVWFC=JY9=:MTN$U*YD-55/HF6-N7,0LJ;:3.41J58RNG=!-4<D"!)4TZKQ
MB]RM/<LB%R?-JX8]2T^=ZIK*OVO&Q67E8_^Z\%(=2VT74)&W],A^,/VS?99F
MA@:7?56S1E6B\20[K/R/>+G!D0UPBE\5NZB;L6=3V0KQ:B=?]RL_L$2,LYVV
M%M1<SFS#.+=.AN-/;^H/>]K V_'5_;-+WB2SI8IM!/]=[76Y\C/?V[,#/7']
M(BY?6)]0['M]]M_8F7$CMR1FCYW@RGU[NY/2HNY=#$I-W[IKU;CKI?>_AL$!
MI \@0T!7G+L!81\03@)01^92_40U+7(I+I[L?JV6VH<"+T-3S)U==+5S]TRV
MRJR>BR@+<G2V1KUFW6G(C8:,%9NY(@P'"3(  P4!*8B+#T<4&#8(08/0&40C
M@PGDNM.D3M-TD E99)-4YBHR4HU@(A F F#""4RGB6^V^6!$4QA E:0I@6%B
M$"8&8*()3#S;)L11,GD,-G,57L0D@6$2$"8!8&+8( 4-TL<?E PTR!YX4+)Y
MHFFR2";E>$\U@EF , L YHX!#N#7-WB\(/A.!\ /E*07C;(-S&?:!^:RX X,
MW @P 6#2.Q9P*\#A?Y0$?H$Q] ;/2A+-.D66!+/.^(ZJPT$W[=J>G]^I/%:-
M\K9"F\[O^O-!",V,8_!DJEN:(WN8<';0=IB:L>S.K6ZB1=N?R6CX8U#\ U!+
M P04    "  T@UQ.-U%T%_4#  !!%0  &0   'AL+W=O<FMS:&5E=',O<VAE
M970S,RYX;6R5F.N.HT80A5_%X@&@KUQ&MJ4=>U>)E$BCC9+\9NSV&"T7!YCQ
MYNW#;1PW?=K GS$PIZM/%7S=!>MK4?ZHSDK5JY]9FE<;YUS7ER?/JPYGE<65
M6UQ4WOSG5)197#>GY9M774H5'[M!6>HQ0GPOBY/<V:Z[:R_E=EV\UVF2JY=R
M5;UG65S^^ZS2XKIQJ/-YX7OR=J[;"]YV?8G?U!^J_O/R4C9GWBW*,<E47B5%
MOBK5:>-\H4]?1=@.Z!1_)>I:W1VOVE1>B^)'>_+K<>.0UI%*U:%N0\3-SX?:
MJ31M(S4^_AF".K<YVX'WQY_1OW7)-\F\QI7:%>G?R;$^;YS061W5*7Y/Z^_%
M]1<U)"2=U9#];^I#I8V\==+,<2C2JON[.KQ7=9$-41HK6?RS_TWR[O<ZQ/\<
MA@>P80"[#6#BX0 ^#.#_#^ /!XAA@)@[@QP&R-$ K\^]*^8^KN/MNBRNJ[)_
M'BYQ^]C1)]G<KD-[L;L[W?^:>E;-U8^M",.U]]$&&C3/O89IFDC7[( F(KIF
MCS14UWQ%&G;3>$TNMX083(AU ;@6@., ' ;@70"A!1 CE[TFZC1YIPFD2R2>
M1L!I!)C&$D#" ')^HCX,X ,'_NC6^T:B-)+N^*[M@"P,7!)A.P&T$TS7_;G7
M4'(W$1.A*T9/[&Y:IQD*H:$0& I&AD(C<4ZER\=^)F6:G0C:B8 =2X V<<0Z
MF?_(4,MR08&+:+Q>#(L*O<N7N(2-JV+361X;BH&GS+ D";&$P,A3OJ P&&>*
M>#8*TXLHTQ+FX[),J'0[>'&@$A2%6D+@Y8'Z"XJ"D::(::,H -8F73FNRI1,
M-X21IB;3DEBV%XHQI-'\LC#,(2,SRC*(Y'VZHY(\E.A&,,W,I%D26RZ6[7;!
M?LLP?0SMN$8Y>A'E^EI!@O%S,D.HF\(\,Y-G280E!&:0+=BA&6:0H3W:*(UO
MDB'<:+S:(IF]:6&8:&82+:TA,(,L7% 6S"!#>Z$_SC>::DKZKA3IN'0#[(AC
MI#E">M2][ :1O6WL#4W*=$,8;8[0]BTA,-I\22MMZ:5GH+WCF%@F@G%A+$);
M6IALCLBVW6U,-E] -L=D\QED[P;1XWYA/Z72[6"N.>+:TEURS#5?P#7'7'/$
MM5&4:$Z_L)^4Z>]H&&MA8BUM;S4"@RCH_+((#*(P.URS+(/H0;^P?RC1C6"<
MA8FSI+80EM=>L: <F#YA]K:@'')>O["?(=1-89Z%R;.DEH9;8 9%L* TF$&!
MWEF-TH0F&=1E1F& C+C^V)!W]Z6I_;CX>UR^)7FU>BWJNLBZ3TNGHJA5$Y*X
M3:W/*C[>3E)UJMO#H#DN^X]Z_4E=7(8/EM[MJ^GV/U!+ P04    "  T@UQ.
M89>$UU,#  "4#@  &0   'AL+W=O<FMS:&5E=',O<VAE970S-"YX;6R-E]MN
MXC 0AE\ER@,T<<ZI *GTQ&FEJJO=O4[!0-0D9A,#W;=?VS$IC(<V-Y"8[Y_Y
M'<^8>'!D]7NSI91;'V51-4-[R_GNUG&:Y9:667/#=K02OZQ9769<W-8;I]G5
M-%LI45DXGNM&3IGEE3T:J+&7>C1@>U[D%7VIK69?EEG];TP+=AS:Q#X-O.:;
M+9<#SFBPRS;T)^6_=B^UN'.Z**N\I%63L\JJZ7IHWY';!5$"1?S.Z;$YN[;D
M5-X8>Y<WT]70=J4C6M EER$R\76@][0H9"3AXZ\.:G<YI?#\^A3]24U>3.8M
M:^@]*_[D*[X=VHEMK>@ZVQ?\E1TG5$\HM"T]^P4]T$+@THG(L61%HSZMY;[A
MK-11A)4R^VB_\TI]'W7\DPP7>%K@=0*1^RN!KP7^IR#X4A!H0=!7$&I!V%<0
M:4'45Q!K0=Q7D&A!TE>0:D':5T#<T\JYGY+H:TFWV*1WEM-R$P](G+:P5*4^
M9#P;#6IVM.JVV7:9[&ER*U0BN!Q5M:]^%-7:B-'#*"3>P#G(2)H9MXQWQOB1
M>\G,3(9TA",L=#X\U,?8,_3 Q;U)!#&Y9!X0YI)XQ** 3$\FX_N7R#,6!C 3
MC %VIA@3@D?[[:.9?V]X82*)BR^0CQ>*KP+XYRY(@D<(\ B!BA!<E!JP.6Z9
M4#&5SD+<%)0"1KE&,: 4S/B(4&[J)Z D>F5\1MT'(-8$HSS8=%.4@D]BAF:$
MS3E'W?L@XP)[$HE_I8U#?(U#HTI"$N 1(CQ"A%0)[(C(< I[>&XB) #+M3"9
M*RT1XU9CQ&H$K,:F#^*!^<P1R'7!(BY,Z(K;!'>;(&YCX#9!C$!H;D(IV-86
M)G+%:XI[31&OH(UFJ9$C2D%SSTU&=!HT:T)7S,J_=/0_U$7L@DX=:^B[K0W#
M_#"$>QN*>;#Z'E',A=Z>4&_F]H9A@1N"UIN@6 "WU"F*);#L9WC2"!8E.M,@
M@2V/8=<W.7+MI8F8"^X9QHF9*@E@ZR.4[X?0-0*% =Q7G;.7OI+6&W6\::PE
MVU=<[LEGH]T1ZLZ3+XU@?$QNIP09G\DCEWK)_ S?GM=^9/4FKQKKC7'QLJK>
M)]>,<2K,NS?"]E8<$;N;@JZYO(S%==V>D]H;SG;Z#.AT!]'1?U!+ P04
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M81"F$]\R@2$<* 0"Z4N_P]!>H"30A_8^_$31$9Q+!.02P HQK!"/7XX)K)
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M.U,TP_]@]]:TIAR]=$,ILU^7:UX-U_/H_\,,&]#1@%X-!)TU8*,!NQI0,FO
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MH0]M?ZNZ^_KRP>ORT)K3^#$ONGY17/T'4$L#!!0    ( #2#7$[VJ*@*WP,
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MB,D^#7D?;;Z_7I3VT(^GR7#>7CYE7"[ZYN0^T\37;T6;?P!02P,$%     @
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ME=3;9[7G=MBL(5D_O2-H?LRR_U!+ P04    "  T@UQ.J6K9J9T#  "'$P
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MB@2V Q%2%0G7#BAU#CH@RG<8);!MB)":2+Q7\,Q<@FLB@6U%A-1$ M5$-A.
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MR<88JYU.<N^ZLG/#[>DFTQM;7RIW7;837GMCS;Z;7H/3"#W[!U!+ P04
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M&?8MA@NCS^.>3'#;&-K\#U!+ P04    "  T@UQ.PG9 M0D$  !-$P  &0
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M8;.84HKL5_]].';?9YO_(PP/X#: 7P) 3 8(&R"^&A#9@.BK ;$-B#\#Y&2
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M<KUKVM/$G%?]"Y[^HBE/]N55>'F#MOH?4$L#!!0    ( #2#7$[3Z:M/40(
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M8R;;SH5W\T'?'*_GJL+-J;3QYC]02P,$%     @ -(-<3M6)#[US @  #@D
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MI3L;X_M#R#TD8V >((QAYQ'"&(__Z=-'L_S<<&I#8@1/D \'Q5<"_B H(:Q
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MX>-@:%AS&#]\DLO7U^(/4$L#!!0    ( #2#7$YQ]7A+: (  *$'   9
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M\4E% +]"'9(U,'8II8VA9>%2(6.*4%-@T7!-_)H![S57FBB;NQA7G#,2_07
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M3I]AR9.A: G_%<[ +=PYL6LTDFO_C)J3-E(L*M:*H*_SR 8_3HO^A18FD(5
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M:79\[5U$BU$!R$1!'\?$%V$"I!W$Z/ARX^+E4CQFI \;UD&>C8KC';T^OB@
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M78CKRI&83(X_5[H@0(@P($^F4O7!9+B6I@9#*TJ@O+_-L8@1)[RSN, = $L
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MKKR>NXC)H#=ZH??(P=\7K13_)TSV.KLNM3_'K$;5ZU_''&2NCCD-U=8 :[R
MVZ=O'SNML'J'&MIKG8V*KCM@:B0P_+1CI[\C07L?E]=,+D&.*G0]YE$W3M%@
MY.%#%12IC(.W8[W-;]GHOG0W)"N#:G!4\U=:+ %JI(RC5TK,+MH*P@T8!T?1
M*:IH(IZ(#^@U'3&5K=)R2D>,RG5IN7WKV)NOK[@ _G-'<TU;F/E.6 \5E>O
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M:LVW:VH3RZ3JR*+6+DX[2H-RUYB$11J%9<W>=JM9=-K/&A[G4)4@(D7][+6
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MR#G0U'0;02*VZ\4^S+Z/V[1ANXNZ/CPWXC\E]D^-@OP/T(:/5QSJ)02X;@#
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M&;E'/;3X!1_Q7R=#HF3PPA@0 V:=#>+IA A@/QKW,6XJF8Y  J._8!\GDZ%
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M Z1 E ;ZK$OTBZ85 D0GXFD&R: _3,@%/9U-^(2,N9Y?%_"A]WTXCB:#093
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M[2(N%X]2B:G#K 4Q.03YWIPB2 09BG-8A) ZX/AK=85R)<GAL'Z.![M8%O<
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MJFY>$>A!6<[&!?RDDI>W(H\U$\E7"UW\;BA;1/<TUG3FO*1X?A<(JRD=WMO
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M"4A2@X^VY?0^W"UN6J/%Z)J>"<RG6!DQLX9O<-Y=@=DK0;LVC+;[&WN 6(E
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MS\AZ+FP6;:H-JHP';3@3F8Z/\#9RZ\_=8C@5OFG9HF!=DBK=9L#5M4]L=%I
MZEP^!2BKWN2J+@$?8S9?P*E=7+,X-49Y>C^TTU>+#(&%*L]M[A4MPQFV^(ZD
M;IMJ:>R?P[-HA;DOTD>'PF9L@63V"ZR#W'?M'%3]M$^CBYA1"BL4;B4A'\&
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M%Z)WM7MXD.0E"^%H=-A+11X^_4);O!9P="7Q\UC&Q]F_0U.<5_PH+'2VW%D
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M+O7Q_P5+/9O ]1U&*(,EQV[(:9H-AF:Q4,Z:.:DE5^T4ZNJ3AE6=!_ZT97O
M X.1_+]G>V2323H>T:Z B<R#!G(]+]L;K*W%]H9^=]#NR,B!5NT#?WKP#NG#
M;2TSHV?_>MD.R2<#^G?0#H'+,0TGOG BU8,2 #ND1VM$[?;OS=HI7/ZH <D]
MM?0 P;.\9,[22);0DE>PHM^;XRR$.N84[?_@_6;1H03[@M.TS;:C '-D5+&1
M4@U; 4K@5]D87L']?9AM]>\["M^5Q"48G_GL.9;ZQ)W*7>2 []1] 9K*^N;^
M.94>$X>4VRFF:BR5WIE;A&(9 .DY1<([\8+Q80));$+,?.>,!D&^;AHS#@@E
M@[KD>'E8348+_(^=U.0B78/ $FNL)[0F+ZO$;,^U=TEB?(F:Z:VML"INR&0G
M,F>VC46+8Z#>[TI12[Z8\C<IWP,,6?NU3.@SWXQ0GY9XXUM:1!P?ZO!\"1I;
M<Q,=PA"]MBH)(I(B 7_?+L23$11?XRF(]J%R(^;%/@O0[)VU6D.X+,1[K1:,
M&=TY"B,*L=X$T0T:GVBGDEPP>H/TRX"]+82;+[O4X]R'R:P2\^M<(C;AP= (
MTWT?W0NQL:@ZRS:+8(DABH1&=BT=ETUEEVE=83K5IC%HHQZU(U,=3[UR $6S
ME<OMC;OV>M[UF^Y_^J37G=K'YX0UN^>-/)Y(A<__-](NZ$;\WZRU-IX48GV$
MF!2B&!,8"[?;;,*$D*0]D[WK4ME/R:H54P6,^]P!DE0R:;DP!_B',6P")RV)
MS](I$0^KBN@@\P%R2"F0FBLRQ,VC!%I54%")@[VUE.DN-O^U!]:/FXA!3/JJ
M7G035U:.D4OBIM&XZ6[RL?3!<S'BYH#DVQ+SA(S,-@S*!RWJV;)88[YS!=U5
M>O4"J>A%C_BC&Z2A5W4>9JL9)T&[=>H!:WRV+ 7\,QND^ <L3TF5/T6$LQD4
MX;V(C@L1I$3RP![,!-CQ;2P()G.]J$GJ>YC@Y;,TF2TB#$:L0-<X7.CSBXAN
M/Q2'"&[0$8;15?K\9O'[@6LT %ZMK<DORM5 $)_A62;HW_(.MO<;&F7,"0GM
M5J:-!:7:LRJYFC&;ZFU0(!T5.SP<*8/G([0>V877R_+%9_8/7IW8X&.7I/HU
M$/5[@^9SI1 ]:*4:*"@#E,Y'G:0U5:XXP05GH9G,L%#(:1:-T+*F4PSD<->M
M(@!"ZJ4F<LL_1$>"^@4(S1D3,VCA7_SR>9,2_04F57.@$&:(8':'H-4H8-0&
M66$8HO"7SZF'#C7UH&F3UP"6RQDIRT532R@>@3T9(CU1125"ABVA["/-'ZW6
MWU6#50R&8N,/6 *[XJ:':*)\^N#N7FNLN%B3*5B?E[9O&^)95PGIB",NQ1G$
M%^G(VJZ+NSLNB5D(N</+X%:[U2%H.4#-R:F'*9,3;,Q=QI5& 6&<*P8%<YW$
M .&A5[5+AD,#%N7M$KVX>"L(=WW]!A:>Z.P@ILO%S(:Y^<@T0^\GJ]\(0V70
MV":"D+6_N:@:$"+7$7-CP"0)%>^&X\9@:2F(E8&U^D<^Z8%$YY\DB6"D4?79
M<,@AE/3E<^>__S_3P>BOT+MRA:'RM =]. I>/=D/@&)U+A@70=;3_3.HG1Q%
M!L,!/QZ*69K,GS?+XA&NMO37S^=7_\SZ\/_HG']XTTV^>N3=@#D[U *T4\*A
M?;W0/<;@+X_X_TE_;,,SRUL[<*D58IPWZ:+E*\'9<!*1U]<APN$-S8V#G"Q$
M#&U!D)*3K%='F>!UQIFC#K$HN20-ME]AW43 ?MYJ^^<_33[_\J63#3'U&5FN
M8PL!2_E&)#[ZK)EZD'T$3-"Y+DJ7EY8FFP>T"3S W-WL\.\[V$2X($CJ/&[1
M;@6G@JP0^$LTU[]_/K?9XLU3-,RG9I!P3;FX?B\-5V;PX708GT4$S7[SV0]0
MX8WL,88=)X 95DU%;!K2N;O4G,86UHD@*]% !-#@EHW8@N,)E =Y)<\][$,0
M];.4DJ-IC8U>IZ+5HZP&Z]#C_I*:QLX\?&$.S>">&5PBJS?'4WKY[(B6.*==
M0\^CSIP?U%.VU5Z^#/3E-$M[^3#H:H7]MT'OAA>GX\$Q8]0V.NR1J:YN2CM/
M/AGFZ$/\M9\<5$W]_1D1:TC?WX8,3)^#37JUN^9L[W-W=']'&&K,U^LA=;BB
MLM).-T<UIBC;SHVVTS((-XQS=<=]:F[!:QF\+R0->>^3+^P#<VV"GI(Q2E'6
MR<6^UN\,Y#?V-%PXFLW[Q6PNN:GH KF"M]\4B[LR32[.G;V%<J*R/CLCZ/<I
M+8ULE'RZO<58 0'Q9SY?(6)^AO(^S))_021L*DZ3TZ<)1@G4O%/PV4]%26S-
M4N(7'_OA8SH1HV!-13^MF=_Q'U=^1#&Y-AF.DZ'W8&597YO92=Z"T'[^!D?6
M@GNH62%YEN2C7C(8#MU[XVSHJ:K?^3ZU%='K)WWC1SU)AL.!K_S78H6IGO<I
M*$H%+IM_P S/8:DXP]8T&=1'!CZ*M>-B]G"]+N9WBUIQ5W"Z.VRF:3(<U%UA
M^!FOA;;%#C.=CG+*,A3?'L]\GDY'?;\1]^V'UR]=)J->?9G 9QB0OJ_9^2C6
M[%&O'NW5&!!]B$@3C',;@O),$?4$1.XTX*8Z?D26G44&FEV7.S&?^(9Y9>NF
MUC 3+CY3DACI?2"2NA&A53_R+CE9:&FI+4P-ECJ'TAC[.;JV\\&0XKJ^KB0Q
M=C$GFRJ58)R7._L]8BT0;0X*"R0@/TM.)],^_)_WTL$X<XFT$J!FM#EFO-'0
M0PI('/0Y[7.0@E+;T TW,F$WQD-."/:*Q'?W(QOTTJP_.JOZAYUAJZ4SH]XT
MG9!CWN$HZ(W5Z0*R-@*\?-,_C,X8P[%O8U1JP99Q&B$[-#[T 08IZZ=#&N/!
M8)3B'JYG[[>@5QVT%8V9_0*AH4NT]/RH--9O\#OL!7MUN'&5Q/QE+9%<%VC^
M_?L:"5AJ -"UCP6YY*VWAOJ9J-?9X$?_:;;Z#98:\<%1&"BF'H]H[^%_I_GT
MS'W:-]H!)C]MDF$_S6%Q9,GI /11^"L;3\U#]8 #5!5 \DXS$WF!6]VD]#_.
M,.PQSX?IN)\EH "-8;GCGR-H #%H_!V1>E8TTMP,6)*3W)5X"DV&3T!I^+B#
M>S=E*/)S.:6]N.= $\9/^K0W8%\-!WP^<,^S49]"LGJ8^3*.B+0#1W0"0F"*
M)PV5.J!%CY\-I_7A'*:8N^([ CV'S_)^^Z#FO7&2C4Q4"T<&U<<41J7OE0@0
MAV?T&8S .5\QN!D#4NS=8R P!W1=B0_^! J=FJ>A4/@(9&5D]/.)>;#/PS^4
M"*%A/F&M@@;K-)OD-MBI]?) 5R6-].<KZ4&[^U,L4/EE&!(^1:R:LT+*139J
M#$,4]Z;S9H8QB-S$23H<X,;!,+X33)\:9#Q8^$';T 3I$6\U/>*@P8EG5B0,
M;25\+7@J*3P9#MKFQ:/V87;-UUY6!WU]<"ZD&5TM^@1K05<<O"@C2,RZ_";7
MIYR&!.ZWV5C2%A=K4PH6O2EOMT_HP9SV1PGF6XSAX!G#-;8W'O 5*42JAJ&X
M*3Q43 C-D:?9:(@',ARIM%!AZXYS:BW,6^N<N$!T+)7G5S/!)%[0!< ?L9:#
M4@M;7E$)J/_^)?Y^13Y=#LAG;V*UBO>7GPDYY4T0IP?"!HX+U]3)*!T-1LED
MF$Y!&K[95R;.ZQ(AT4WD?]X?PLSWX8" FP=F !"DRGDCI H\WAOW4!?LI_T>
MZH*$X;5"+S[LTT$N_^\K!Z420K-,,Y#1"OC#2.5XT;@O'C<(&@+GBO[86V*6
MC@<#7%(]N*(,5$N]L_/*1J'VV74P,#U47J=T>H/RNB>%Z%QRY8RIZS!C8R3'
M[GN75\!L@#NJ1S<U^#D9PC#>P:A,88H&_9Z+=(S['J$M SA5^G 8>N(7?71[
M7ZSG'*#"&;'Y,)F""N!,39)H>KTN?UNL/5V"H?G#HW*4^1/U\V*[6Z\T@Q!3
M:J8]\Z7-.&2 EU#*HX ;D%#/&;TGI\L#IDZ,]^1I.W/?L?.W1\%M,"16C%7M
M2FTM(LL/L0GG/O?@F.>";;N)W2/;7XWD^U/L+UHK1S2:IW2C/&L(),[T*;2O
MGM V']+#0U@=WE]#1V]PL\-3OOK)0&Y_IWT437Q(#.B3(3VKD3SQIH31S3WS
M\S33+IQ.,5&1\P8T_0>?RRI=U;9I"9EK&FAVW%58?*3W9OAL1-\RGNU_4MO&
M09DX(=4'Y?!U?B+GK-WG/V*Q-M(>*-CG@?*'UNC5OL)JQ'*OO2VN$E_AT^-P
M"OK#7(*XR6XZH9SFOS.$.&L:\X<"/6\"P^I>AJD93 >4+3KI$=K8<,SJ((;E
MH[4$U!]2IZ',:;N\9QR!3QR8>HD1L>="U'?03+QSLU!4+>2[=<!MRN&VC@60
M[7S*B>C,4Z\54<!A*YP+MH(#XZ",C?KW'N_BPL0+?^%;&2$Z;.!VHSEZH%N!
M^$5H"!8=I^_MBG! V=&(7U#UQB.XH.'L#?M=^&38I6R=; @B>M"#&_J,Z+'R
M'"9YE,.=+._V/)P()1S#WD1]<3CLY@,,=46&#TI2A$,?LQ2S;- =]ML:@EKN
MN \-Z0V2T:@[SJ 9 V@=W) G0P?JQ-&4\;?[&>;;#9+!N-OK)U#?"*J%+L!=
MXI/$[.(%1:)\K.7V&U',-W@JL%D#:M:);=B):]K+UB,&P%06P6<,JGK).M6X
MS.OU8O;;G'#M64=10 UKI6KHYVNNGJQE 5#,QHV>+:4&%K)V"Y:26163I?Y@
M6+HK?&$F>-\[)Y,NC'N'@Q;@ CD9I.,>+,PNX<?AASWWH?Z-SX("@B_EW4F6
M#$:@D/00[@M>S+JPSN43_N,$%BS,<D=_R1$5$>0G;) LD8]Z??J(_SK)1EU8
M:1TB"IJ =C9),?NTAQL*O@)9*)_P'R=YAC5W]!?0B>BF->BBUA]\Q'^=]&G7
MP0O#41>.M&R2I^,1;=9>,NPAI%DV'L"!27]!/TY&?1FET1CW'EZO^P-<O+#!
MQMT!H;=D\ 7^ >T?#_"SCOZ234'^@G8PQ%$+/^*_3B90]91G@:K/IZ#:3>#A
M+J8<]KL@45"$3* +TZP+@@,>S+H@R3L.[*T_[%.&[P1+R@8PK3U*^D5]L9^A
M&/*[3W8=;T&_VT]DOQ^\"W5Q=534&KS 6+9L#0/*A4B# .%@[+7+T5-L<<62
M\@2O0;"CABIW=('?$4)=)3\^9![7O7S'XOA@6)]FV*;QJTZ_VT/HIMZK3M[-
M7\$.ZK_J9(B YQS2)J^B#U_V1Z_@AO*J@Y!/@\FKSK!GGB6C(2P8E*G#[D0D
M %*LP <C\\&(/QCS!^V1),[LQ+-XU'D>:E:Q,[U.Q'[LD>[6$9V3[)DV6OPG
M*WJCYV^_G^937,BX2_QQ.\I3^ K$Q12W_R]\<IV.LG0ZF9XE$Y VT^"D9<L-
M'$I=]%*WUPJRHI^G^9C=W%' + %'^(($; =IQ*$/T+^>_,0D7@=/6-UG9QC!
MG,XKU&!GM!V%1H#B1#T[(U/:-P;Y'+A_U !;J_EU\FXQ)^TV?K_),Z8!@LLZ
MB#,\-O)$Z;Q/LR%H1?G(VZ/S$9P0("IARAVB1$N5^11N.)-D #>>,0.N@FSG
MZDZSR1!="Q.X[@W@GJ1U5AW+OJ5]=.A-R5>5CL:D:L/1D[??SCUAIIGKS]B
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M7PEA[H]@HTTQ! "4G<](A7O@FZ<@'MCA.IS@BLU&O< &+#@2TF\01OED&AF
MVAKQ-^>OJQF<:=CG?^50ZN5SD-GAXS,/N3GN*>,%-WT;\^_;(D#F!%*8K/#C
MI4$I,[D&AHS#,<B5C[#!>3G[$Q.W%V+'X[!07@_+GP#-P)N!-AZDD%D,Z9(3
M\ UVA;J']L9_N'&9S[:4@!-1G)HV0RO:WCNB:))Q3ZYPP[JI1.+)M?_K78G&
M9?<G->"+9>2A4W"49N2T@5.P-Z"H1PYL0PPQ<A=70Z\QQ":@K-N@9SA#<RJ&
M<TX0\;S?RRA4=9!9J,93>>',W69PI??Z% F+,A9E;88!+"!L,[0=CDF<AE<X
M:%\^GB;C/L%9C\;DV3@=H!C.SP02O#9RKR,%P;[I4JQ=O\M84&B704]KMP<%
M*:+X@45E70H)RKN$$99W)SU?5 ,\MYP8# R>@[A!D9%1M YB=<,=#K&ZQ]F>
M]Q7B.A^D$PSN@&,"3;IPIQOF6@*MN=K<@]C(1\+2,J4@MSY:9@E(KI<.1L,#
MY[XW1,,Z* 5H(D\GDQR7 *8RO(_8 :!G>);"L9ECZ.%I'PYG/,+[8]"L!F>1
MP<4 F2E&1<']<4).X5,$UQP?.=D]='#1CRG]()CCTUX7E]^1DPUEY/QC1#_Z
M(U_409/=2Z=]GE[R&? <H88Y/72R^WAEQQ\Y;#SX@9AT4L*?0C;627[&>$"Z
MP)U*J'/M:.@30L']AJTCU6_AA.^ZT_WKU9OD].3L)/F+=+!VS"P>NWC"'?;T
MO^Q61SS]<;8^HB6VW>.CVKW_:=ON_4_;=N]_.C;>B$, \_J_Y[/GPUX<'5--
M;]S2TQGTM!>VI@9F?+.%9T9!_]K*:7H&>3=Z?6Y_]'WI7(]XR@[;+VUP^A\5
MK4OXRLO;9A[T%)20WXN'W4-]\S#F0O7S7Z'D10=]PX&^6EYO2HH]Q%#O%1H6
MJR]^KA+W)J=A/"D:6[;UP:MF1KO<J+J/#=2-#@:L/=LTCUIJ=6,!RC3H;Q75
M)][6.3(ZCM3A%*???7&6_)&T;$MC!&T)\_F;XSJ9(Z'/^LA:_HZ6%40B*C:J
MX[.*STC^2.!;?>42TSH)D$EN!YSXCRD6;*VFM!SF6IX;>W6U'#RG&-V#\T3)
M;"[:-.'LD'.L;CO\FW6Q;J!W.;*Z\8=P?N--&40^!D!47SPGL\0";:HS902%
MU5]]+.LU^ HK]:*?+,G^,E'<'8=" MMH52#?C8$W)G\K_,[>UZ,;C?=X[_2M
M/C-JV(GANR0[8$NA:Q+Q)Z#2VE[*\NZP]^K GH/"1_@NW&GB.(=-]=S9/I4*
MQW)$1P=Y0R] )YW4FO01KD@1F=1$9K#;+&YW2XH7J8NQZ&Q_C L]1^<70>FN
M%>&B'>'*N)X]+G;;XJ:^#QR@N D59;.2<'+^D43%/@?D/C>G:N-H,"&'/-D^
M]SD&K]0&VG%S_I'LKU!M#JBVNW!A S' T# $"2*BS4.*'%4Q?-BP H9'=P++
MBD_V%&Y%M;*8U/20T;@,P(:J Q(Y.YR;,PR?(*@E>&FV<2DQ?*G?,Y^CV%!X
M'M9#NO"V*BRQ,;J<7.Y]?27E_68NI#_:LG3_=EGEQ#.A8/7  1DFPM+#9$\/
M3=$^-L3T56]V&X53>[._*#18<JW9](23>TNX?@9UPW'^U>40OM J'3!CC=:'
M:,5<Q1^)49)KJ]5?C:YP%,DW\/61CB/4-CN]:6V%L,8%]72$%,J8MQG*)6"(
M_7IDG8-(G?N;F1W]2C:LO?+IXCV>0N(ENQ05\'P+^^%ZMU6VE)_+%2'GELLE
M/N96V1_)"YKIE%K5#/<^<% ]M1%\03&QB7A9:VJ]?B/@7C<(O;5]0M EU9W_
MOBOF9!X&?9$E'CR"\DT0\<@N2-SRH][H99T(^?_JQ[)GPB!(P9;3XDT!<A?N
M*K6+WQ.!312/A J.\$T493N7Q_=)YIA@]ODU?W@.8453VS]X;L@:U(04,QD?
M0*N>[7W@SVK /YY!U8^PP=4>^+,:\/9;^0 7TGW?_UG5DW^S_=L?7/4/LJ1I
M"Q@BR#PN%/8;;V%#[!3-Y8.C%)>_Z \8'.K+JN\Y*BDY;[ARIZ"C_7NY=H77
MSM_05MR^_P9137<0U9<&65RAY.;^5+M ]6./9]/HIX.VHB_J]])>M-T_>))!
MC%V5N_7-(IA4,5PE)[CZOJCGI]4&VFK$;+5"MAH=6VV,]9-@H_12HJ]H-]O,
M8Y9OOM':5/LFNKU_T.08) )MW&>^'-I)XJ_P57.[.73NWE%40><#1174,JA;
MQVM?WG%M?"F1=]:0R!O?V@:&4G%Q^7I,<0?Q2QKE3R?NQM-TSM?7XA)CL_ZD
MJ7QC0O,:'1.TXI7+OLV^[OF:#[2K-S]VOKMSCPW:2G/TTN\MRAV,PS\OYG>T
M^ISM#A2H#?*?[3",O6T)A8S151P<0Q1=L6[6K[<AJP:;H%JNH_4":NS6>ZJL
MDEU[VI\?W%2\L<<S+%KFR %4I4JAUJSXOJ1%AH:[T2;S_>7&[3,O*;?];O"2
M$NMTXC]DI@]A(3^LHA:KQG<7</B:?$G1+U]<QY1[S.)J+_<EBZN]Q)<NKCU3
M]I+%]:-4F9"0/G"873&IO%%IA&13N39;])=?JXEN 2]\D%':$7+[4_ZNUM.]
M)//U2THEM:NIY)!\ONDI1T#?]$#[_#96?B3E?%,Y/YYUOJFF: !K-+(C4'/_
M8M8+PG>"CMBN^Y(>U8_?3,X?X7Z1-3CG\455F>HZW!)>',8O)E2J7&E:7?ZU
M+P,UK>Z>6CL()!;%;]DXU:9[_6*@!PVMK$?<K=JPK6JVBATC=6WN4*5(EWY=
MH[E& RPO@381N"QG*P]_R@QE$5<+PV]\7&SOR[G$22]JHM6C'I3.WK?'?SKN
MCNHW]'ZOVZ]_^EYYL4XU]>#,< P^<-,\+E[M$H4!]QB(L,;MMM>M.XAXLER<
M- V:XLHRB<.C<#"C:%=9?4NQG#<2\>]]]7""K#:SF]CE362.6TN/NS7B<1+C
MVL</YW#Q@_EAATV##&AK)0P7N<-^5&O9!L=\%(L'A N$4ZUX@+K6NO:+B$BJ
M%J-1%39!S"4+M)F29<^V3^8DYI7T&,[EP[5 5Q\8!!<+8F*6ZT^W%X@<?%VR
M1&AV$W*,TR0(P(I6TV^/IXI%@+4]TQ1/Y>)TQ%.I$*Z<-L*(1AV-3=*$EO91
MC[\C/DK.MV+>EXVM-3I:8FF)&TM:8Q7RAM 41C9]-&#XPG7OO)&U,WQ=_OOB
M)O G>SQ=\CJW#T<_:KO\M5PSTYQL.N\XC!MU#@BB4"X#=<XIY!,)%H%3J@UP
M%5!7PRK::PI./Y(2G.92?Q!M[AY!#P-BUJM9Q+,QC4]7O0#I5=WD&XU 4 7W
M13,WB)U0]19]^OBEUIIA+#C(>[Z]=76#8-D@<TXRGVA']#3X,")V&ZD21F(T
M#T1DN;57W:W4C>D%+ZC:>N#MNS/[[I'RLDE:BZWUG#?OO)I%R_@A>-H?;9D/
MI&_K"= JVULN/K@:HU\[Q#XA7..0),ZFJ;7S?44<\M0Y\_(MAE/>X&+U")9-
M]N*6K2XW4QN;5!>0K&*XO %#*1+ W=:VDGP;YB73O$7LYM&TNZA)^\/^\DSZ
M0G/'FM9>*/Z^>/%W^"7K@%NZB/-B;F7YID66ZY)?-B:3<YE[YIL,'"NWE;6E
M3(37I'H:;!4;--!I2'+7APC8U[R+SD^7^\56%#^D[=LV%MG>W,IT;\."IN!3
M/Y>K=:5M;5=%-C!8IFJL7&BBJKFP!UYX5M$RH[JR:WMDE1!P:_.K'^SV.J &
M/!":R.P;3HK#WD5:SQ>]Z<))V][^$)!_&<@A"[#>A/7:5G <J[WMC=I:B5^6
M["MQTN2V-_Z5B<HN'4/9.4=0?C0,9>\=6[QL#V%/R"+WAA]5\G<NGS^Q\GWK
M[\^K^J %_-W5_VD[X+M;=OP6^NXJ7[ 'O[O.XS>Q=1JP">;3-:J'8LDDUE_'
M>/+#"OK.+?KCZMJW(W]830=MP&-K^_-.G",;<OSV.K:&%^RF8ZOXOLWS=54V
ME=X_>..T%O(#-\W+ZSEFP[RXEJ,WR[Z:_E,VRKY&?-\FV5?Z=VZ0?<4?MCD"
MY_X+%%)[]46JGN1+ 9?J/QP9\862$7]!,N*X*5;=ZFPCJ'L-*>( RFRJZXTE
M9/[L")E3%]+F@N$^AIS,7YB3V063'U^U3Z>]M$3#C24V7I*/9.9]@5%+N'/;
MS;][R%DK"#WQ!,M&0ETBOZ# XV9BW>]LGD#HQ!O6#+'WMV.Y;:,.C^B'M!X:
MA'V=?':_NQZF^",;:B."R,.A'E+5P2RXAQI@+F/TFWNY:&L&UD9"S;1&+7O,
MNXZ%=L]+F^ MQUA[3%5D5?V>?D6-F@=U[N@W70>/?G.%#KAH5^.TOIV0U)>R
M-PHXNU=%+:JXC::U$Y"TMI5R,"_L_H5U1%&-Z^R(,AI7W1%E1&?F8&+C3D!K
M_$?R#XP#J&^"!CKCMEDY@,KX@*710F+\1^6#0QK0S&&\K[3&R+*#X@G:87/V
M![(?^,K/Y;<:@DX+9HT&TQ^ 6>-"NB9MB;4V#$L*A<>B>#6'=Z"MEL9G3"A9
M<]#$]=8H6ZTV_L,X;??&@+D@1G&RP"G["#N]N$' V 6IY.IW@049'Z*79@4D
M;9@G!#SBD))O VW,X"8W]*=*$'),S2[0[BD<F^AL!<3%->3'?5."Z?!MVQJ_
MA^,.%'1V5S;.'FC8VR7ZR J-?FV>KC>*'$D1*!X+ OU]G6+5<;%8(%">*A4T
M*EX2?2B$<7;T:E<O#+L2S+/28F"WJ;FNHP&]\@&=Q67T&" \!'S3M:7LP!T.
MB-$8=B?]2(Q&!4V6YYN@>,CM&5U&YB%>L":^]XBE^_ZV(\L+B3IH'6.LXN\(
M2=D*:]#@]"M>6AX<1&28%BX&Z5M\K*C7LK>_+9A*Q14LL5M[%M'B=]04=\7F
M7F]WL9T5+-:XB-J##F(6J[__M:V PT/]YXL'(85B!(]/=4PG'^-R.++$E<F0
MDM WNEPN9YM-<?M<DT9X7=;(B3W1JOUHM,^/Z?V7I]H^:>Q]I-=J/]G:T"/J
MGKX;CDA[3Z>36$=# P'A_/KE+,@;$>%6:VOD&'G!2>.*/^ZP:=CWIMWQ\)G]
M[[79+%Z4:'7 !ODQ!4?67HNJ+3'J-I;CN4)]\\X%-9_C*7:W:+2DM2G<\2"/
M2XZY3!TKC82+-"@,AVF--&:'99[5S+(<UB6-,?!]'#\B(:+QMY;EZHZ-WH>^
M5PLA=8W;\"SQVX'2T.2A_+J2]&8$,91(S=HE5C"SK^X7"Y<YE<@\PC0:T_<%
M[,Z[<ETL7F(RI0U_A49Q"84Y_P8%X ATX.SJ(#17^^4 1$3<Y(U8ZTP@05B
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MRF)[.:,-7A^'OVPVV[_]?U!+ P04    "  T@UQ.N-E.2GX"   ,#P  #0
M 'AL+W-T>6QE<RYX;6S5EVUOFS 0Q[^*Y4Y3*TT!DB5I5T#:*E6:M$V5FA=[
M5SG!@"4_,&.RI)]^-B9 B)*L63J5-^%\Y_O?SV"<P\_5FN+'%&,%5HSR/("I
M4MDGQ\D7*68H'X@,<QV)A61(Z:%,G#R3&$6Y26+4&;KNQ&&(<!CZO&#W3.5@
M(0JN GA=NX#-OQ,1#N#3Y?M?A5"W[X"]7GRXN' '[M/5;3=R686N(+ Z7Z,
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M;V-0<F]P<R]A<' N>&UL4$L! A0#%     @ -(-<3NZIZ/[O    *P(  !$
M             ( !F0$  &1O8U!R;W!S+V-O<F4N>&UL4$L! A0#%     @
M-(-<3IE<G",0!@  G"<  !,              ( !MP(  'AL+W1H96UE+W1H
M96UE,2YX;6Q02P$"% ,4    "  T@UQ.Z[O8KK\"  #-"@  &
M    @ 'X"   >&PO=V]R:W-H965T<R]S:&5E=#$N>&UL4$L! A0#%     @
M-(-<3O5WU.^_!   QA<  !@              ( ![0L  'AL+W=O<FMS:&5E
M=',O<VAE970R+GAM;%!+ 0(4 Q0    ( #2#7$Y+ M"U^ $  (<%   8
M          "  >(0  !X;"]W;W)K<VAE971S+W-H965T,RYX;6Q02P$"% ,4
M    "  T@UQ.&5V(:<H%  !-'@  &               @ $0$P  >&PO=V]R
M:W-H965T<R]S:&5E=#0N>&UL4$L! A0#%     @ -(-<3F7JA_MB @  F <
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M965T.2YX;6Q02P$"% ,4    "  T@UQ._"=BZK,!  #2 P  &0
M    @ 'S+0  >&PO=V]R:W-H965T<R]S:&5E=#$P+GAM;%!+ 0(4 Q0    (
M #2#7$ZH4K/DM $  -(#   9              "  =TO  !X;"]W;W)K<VAE
M971S+W-H965T,3$N>&UL4$L! A0#%     @ -(-<3B*>A-^T 0  T@,  !D
M             ( !R#$  'AL+W=O<FMS:&5E=',O<VAE970Q,BYX;6Q02P$"
M% ,4    "  T@UQ.V>08+;,!  #2 P  &0              @ &S,P  >&PO
M=V]R:W-H965T<R]S:&5E=#$S+GAM;%!+ 0(4 Q0    ( #2#7$[7WWXIM0$
M -(#   9              "  9TU  !X;"]W;W)K<VAE971S+W-H965T,30N
M>&UL4$L! A0#%     @ -(-<3A]+4T"U 0  T@,  !D              ( !
MB3<  'AL+W=O<FMS:&5E=',O<VAE970Q-2YX;6Q02P$"% ,4    "  T@UQ.
MA$3W/+0!  #2 P  &0              @ %U.0  >&PO=V]R:W-H965T<R]S
M:&5E=#$V+GAM;%!+ 0(4 Q0    ( #2#7$[G9<$5M $  -(#   9
M      "  6 [  !X;"]W;W)K<VAE971S+W-H965T,3<N>&UL4$L! A0#%
M  @ -(-<3A.B=*BU 0  T@,  !D              ( !2ST  'AL+W=O<FMS
M:&5E=',O<VAE970Q."YX;6Q02P$"% ,4    "  T@UQ.4]0:KM,"  !*#
M&0              @ $W/P  >&PO=V]R:W-H965T<R]S:&5E=#$Y+GAM;%!+
M 0(4 Q0    ( #2#7$YP<XXLYP$  &8%   9              "  4%"  !X
M;"]W;W)K<VAE971S+W-H965T,C N>&UL4$L! A0#%     @ -(-<3BY4S885
M @  M@8  !D              ( !7T0  'AL+W=O<FMS:&5E=',O<VAE970R
M,2YX;6Q02P$"% ,4    "  T@UQ.31<1 <,!   W!   &0
M@ &K1@  >&PO=V]R:W-H965T<R]S:&5E=#(R+GAM;%!+ 0(4 Q0    ( #2#
M7$Y+\\D^LP$  -(#   9              "  :5(  !X;"]W;W)K<VAE971S
M+W-H965T,C,N>&UL4$L! A0#%     @ -(-<3L'+<%VV 0  T@,  !D
M         ( !CTH  'AL+W=O<FMS:&5E=',O<VAE970R-"YX;6Q02P$"% ,4
M    "  T@UQ.MJH#P/@!  #+!0  &0              @ %\3   >&PO=V]R
M:W-H965T<R]S:&5E=#(U+GAM;%!+ 0(4 Q0    ( #2#7$ZKV J([0$  &8%
M   9              "  :M.  !X;"]W;W)K<VAE971S+W-H965T,C8N>&UL
M4$L! A0#%     @ -(-<3@%!BTWB 0   04  !D              ( !SU
M 'AL+W=O<FMS:&5E=',O<VAE970R-RYX;6Q02P$"% ,4    "  T@UQ.%&C1
MRK<!  #2 P  &0              @ 'H4@  >&PO=V]R:W-H965T<R]S:&5E
M=#(X+GAM;%!+ 0(4 Q0    ( #2#7$[E"P\PT0H  -5%   9
M  "  =94  !X;"]W;W)K<VAE971S+W-H965T,CDN>&UL4$L! A0#%     @
M-(-<3I=12J \ @  @0<  !D              ( !WE\  'AL+W=O<FMS:&5E
M=',O<VAE970S,"YX;6Q02P$"% ,4    "  T@UQ.TLV^3X #   J#P  &0
M            @ %18@  >&PO=V]R:W-H965T<R]S:&5E=#,Q+GAM;%!+ 0(4
M Q0    ( #2#7$XCON9<5@(  "0(   9              "  0AF  !X;"]W
M;W)K<VAE971S+W-H965T,S(N>&UL4$L! A0#%     @ -(-<3C=1=!?U P
M014  !D              ( !E6@  'AL+W=O<FMS:&5E=',O<VAE970S,RYX
M;6Q02P$"% ,4    "  T@UQ.89>$UU,#  "4#@  &0              @ '!
M;   >&PO=V]R:W-H965T<R]S:&5E=#,T+GAM;%!+ 0(4 Q0    ( #2#7$Y=
M+:/(< ,  /P/   9              "  4MP  !X;"]W;W)K<VAE971S+W-H
M965T,S4N>&UL4$L! A0#%     @ -(-<3N0*"D'^ P  710  !D
M     ( !\G,  'AL+W=O<FMS:&5E=',O<VAE970S-BYX;6Q02P$"% ,4
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M+GAM;%!+ 0(4 Q0    ( #2#7$Z4[2^\[ $  -@$   9              "
M 2B)  !X;"]W;W)K<VAE971S+W-H965T-#$N>&UL4$L! A0#%     @ -(-<
M3JEJV:F= P  AQ,  !D              ( !2XL  'AL+W=O<FMS:&5E=',O
M<VAE970T,BYX;6Q02P$"% ,4    "  T@UQ.&*#,)O8&  "G*   &0
M        @ $?CP  >&PO=V]R:W-H965T<R]S:&5E=#0S+GAM;%!+ 0(4 Q0
M   ( #2#7$[#+5\=T (  /D*   9              "  4R6  !X;"]W;W)K
M<VAE971S+W-H965T-#0N>&UL4$L! A0#%     @ -(-<3H%XC*UR!   2!@
M !D              ( !4YD  'AL+W=O<FMS:&5E=',O<VAE970T-2YX;6Q0
M2P$"% ,4    "  T@UQ.[A0SJ/H!  !M!0  &0              @ '\G0
M>&PO=V]R:W-H965T<R]S:&5E=#0V+GAM;%!+ 0(4 Q0    ( #2#7$ZL$YEW
MYP(  )(+   9              "  2V@  !X;"]W;W)K<VAE971S+W-H965T
M-#<N>&UL4$L! A0#%     @ -(-<3IC4Z59T P  3@\  !D
M ( !2Z,  'AL+W=O<FMS:&5E=',O<VAE970T."YX;6Q02P$"% ,4    "  T
M@UQ.3DF/GV8"   E"   &0              @ 'VI@  >&PO=V]R:W-H965T
M<R]S:&5E=#0Y+GAM;%!+ 0(4 Q0    ( #2#7$[9]4:/Q0,  "02   9
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M970U-"YX;6Q02P$"% ,4    "  T@UQ.U8D/O7,"   ."0  &0
M    @ &@O@  >&PO=V]R:W-H965T<R]S:&5E=#4U+GAM;%!+ 0(4 Q0    (
M #2#7$Y?[-.U<0(  -L'   9              "  4K!  !X;"]W;W)K<VAE
M971S+W-H965T-38N>&UL4$L! A0#%     @ -(-<3O'E UVD @  A@D  !D
M             ( !\L,  'AL+W=O<FMS:&5E=',O<VAE970U-RYX;6Q02P$"
M% ,4    "  T@UQ.'',D8U #   -#@  &0              @ '-Q@  >&PO
M=V]R:W-H965T<R]S:&5E=#4X+GAM;%!+ 0(4 Q0    ( #2#7$YP7>RBP ,
M *P0   9              "  53*  !X;"]W;W)K<VAE971S+W-H965T-3DN
M>&UL4$L! A0#%     @ -(-<3LD<P-!" P  B0T  !D              ( !
M2\X  'AL+W=O<FMS:&5E=',O<VAE970V,"YX;6Q02P$"% ,4    "  T@UQ.
M<?5X2V@"  "A!P  &0              @ '$T0  >&PO=V]R:W-H965T<R]S
M:&5E=#8Q+GAM;%!+ 0(4 Q0    ( #2#7$Y=P9M5(@4  $P9   9
M      "  6/4  !X;"]W;W)K<VAE971S+W-H965T-C(N>&UL4$L! A0#%
M  @ -(-<3C6\4U'. 0  I00  !D              ( !O-D  'AL+W=O<FMS
M:&5E=',O<VAE970V,RYX;6Q02P$"% ,4    "  T@UQ.XG&KQ9++  ! ( ,
M%               @ '!VP  >&PO<VAA<F5D4W1R:6YG<RYX;6Q02P$"% ,4
M    "  T@UQ.N-E.2GX"   ,#P  #0              @ &%IP$ >&PO<W1Y
M;&5S+GAM;%!+ 0(4 Q0    ( #2#7$[A#\/0# 4  #4J   /
M  "  2ZJ 0!X;"]W;W)K8F]O:RYX;6Q02P$"% ,4    "  T@UQ.N/4##B,"
M   2)@  &@              @ %GKP$ >&PO7W)E;',O=V]R:V)O;VLN>&UL
M+G)E;'-02P$"% ,4    "  T@UQ.=1XKO^\!  !])0  $P
M@ '"L0$ 6T-O;G1E;G1?5'EP97-=+GAM;%!+!08     2 !( *H3  #BLP$
"   !

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>80
<FILENAME>Show.js
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
// Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission.  Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105.
var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0);
e.removeAttribute('id');a.parentNode.appendChild(e)}}
if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'}
e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>81
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
/* Updated 2009-11-04 */
/* v2.2.0.24 */

/* DefRef Styles */
..report table.authRefData{
	background-color: #def;
	border: 2px solid #2F4497;
	font-size: 1em;
	position: absolute;
}

..report table.authRefData a {
	display: block;
	font-weight: bold;
}

..report table.authRefData p {
	margin-top: 0px;
}

..report table.authRefData .hide {
	background-color: #2F4497;
	padding: 1px 3px 0px 0px;
	text-align: right;
}

..report table.authRefData .hide a:hover {
	background-color: #2F4497;
}

..report table.authRefData .body {
	height: 150px;
	overflow: auto;
	width: 400px;
}

..report table.authRefData table{
	font-size: 1em;
}

/* Report Styles */
..pl a, .pl a:visited {
	color: black;
	text-decoration: none;
}

/* table */
..report {
	background-color: white;
	border: 2px solid #acf;
	clear: both;
	color: black;
	font: normal 8pt Helvetica, Arial, san-serif;
	margin-bottom: 2em;
}

..report hr {
	border: 1px solid #acf;
}

/* Top labels */
..report th {
	background-color: #acf;
	color: black;
	font-weight: bold;
	text-align: center;
}

..report th.void	{
	background-color: transparent;
	color: #000000;
	font: bold 10pt Helvetica, Arial, san-serif;
	text-align: left;
}

..report .pl {
	text-align: left;
	vertical-align: top;
	white-space: normal;
	width: 200px;
	white-space: normal; /* word-wrap: break-word; */
}

..report td.pl a.a {
	cursor: pointer;
	display: block;
	width: 200px;
	overflow: hidden;
}

..report td.pl div.a {
	width: 200px;
}

..report td.pl a:hover {
	background-color: #ffc;
}

/* Header rows... */
..report tr.rh {
	background-color: #acf;
	color: black;
	font-weight: bold;
}

/* Calendars... */
..report .rc {
	background-color: #f0f0f0;
}

/* Even rows... */
..report .re, .report .reu {
	background-color: #def;
}

..report .reu td {
	border-bottom: 1px solid black;
}

/* Odd rows... */
..report .ro, .report .rou {
	background-color: white;
}

..report .rou td {
	border-bottom: 1px solid black;
}

..report .rou table td, .report .reu table td {
	border-bottom: 0px solid black;
}

/* styles for footnote marker */
..report .fn {
	white-space: nowrap;
}

/* styles for numeric types */
..report .num, .report .nump {
	text-align: right;
	white-space: nowrap;
}

..report .nump {
	padding-left: 2em;
}

..report .nump {
	padding: 0px 0.4em 0px 2em;
}

/* styles for text types */
..report .text {
	text-align: left;
	white-space: normal;
}

..report .text .big {
	margin-bottom: 1em;
	width: 17em;
}

..report .text .more {
	display: none;
}

..report .text .note {
	font-style: italic;
	font-weight: bold;
}

..report .text .small {
	width: 10em;
}

..report sup {
	font-style: italic;
}

..report .outerFootnotes {
	font-size: 1em;
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>83
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version='1.0' encoding='utf-8'?>
<FilingSummary>
  <Version>3.10.0.1</Version>
  <ProcessingTime/>
  <ReportFormat>html</ReportFormat>
  <ContextCount>397</ContextCount>
  <ElementCount>478</ElementCount>
  <EntityCount>1</EntityCount>
  <FootnotesReported>true</FootnotesReported>
  <SegmentCount>129</SegmentCount>
  <ScenarioCount>0</ScenarioCount>
  <TuplesReported>false</TuplesReported>
  <UnitCount>8</UnitCount>
  <MyReports>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R1.htm</HtmlFileName>
      <LongName>0001001 - Document - Document and Entity Information</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/DocumentandEntityInformation</Role>
      <ShortName>Document and Entity Information</ShortName>
      <MenuCategory>Cover</MenuCategory>
      <Position>1</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R2.htm</HtmlFileName>
      <LongName>1001002 - Statement - CONSOLIDATED BALANCE SHEETS</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS</Role>
      <ShortName>CONSOLIDATED BALANCE SHEETS</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>2</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R3.htm</HtmlFileName>
      <LongName>1002003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical</Role>
      <ShortName>CONSOLIDATED BALANCE SHEETS (Parenthetical)</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>3</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R4.htm</HtmlFileName>
      <LongName>1003004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS</Role>
      <ShortName>CONSOLIDATED STATEMENTS OF OPERATIONS</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>4</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R5.htm</HtmlFileName>
      <LongName>1004005 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS</Role>
      <ShortName>CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>5</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R6.htm</HtmlFileName>
      <LongName>1005006 - Statement - CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY</Role>
      <ShortName>CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>6</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R7.htm</HtmlFileName>
      <LongName>1006007 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS</Role>
      <ShortName>CONSOLIDATED STATEMENTS OF CASH FLOWS</ShortName>
      <MenuCategory>Statements</MenuCategory>
      <Position>7</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R8.htm</HtmlFileName>
      <LongName>2101101 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>8</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R9.htm</HtmlFileName>
      <LongName>2110102 - Disclosure - Investment in Viking</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/InvestmentinViking</Role>
      <ShortName>Investment in Viking</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>9</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R10.htm</HtmlFileName>
      <LongName>2112103 - Disclosure - Business Combinations</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BusinessCombinations</Role>
      <ShortName>Business Combinations</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>10</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R11.htm</HtmlFileName>
      <LongName>2117104 - Disclosure - Fair Value Measurement</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/FairValueMeasurement</Role>
      <ShortName>Fair Value Measurement</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>11</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R12.htm</HtmlFileName>
      <LongName>2121105 - Disclosure - Lease Obligations</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/LeaseObligations</Role>
      <ShortName>Lease Obligations</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>12</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R13.htm</HtmlFileName>
      <LongName>2125106 - Disclosure - Convertible Senior Notes</LongName>
      <ReportType>Notes</ReportType>
      <Role>http://www.ligand.com/role/ConvertibleSeniorNotes</Role>
      <ShortName>Convertible Senior Notes</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>13</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R14.htm</HtmlFileName>
      <LongName>2129107 - Disclosure - Balance Sheet Account Details</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetails</Role>
      <ShortName>Balance Sheet Account Details</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>14</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R15.htm</HtmlFileName>
      <LongName>2137108 - Disclosure - Stockholders' Equity</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquity</Role>
      <ShortName>Stockholders' Equity</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>15</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R16.htm</HtmlFileName>
      <LongName>2145109 - Disclosure - Commitments and Contingencies: Legal Proceedings</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings</Role>
      <ShortName>Commitments and Contingencies: Legal Proceedings</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>16</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R17.htm</HtmlFileName>
      <LongName>2146110 - Disclosure - Income Taxes</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxes</Role>
      <ShortName>Income Taxes</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>17</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R18.htm</HtmlFileName>
      <LongName>2153111 - Disclosure - Summary of Unaudited Quarterly Financial Information</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation</Role>
      <ShortName>Summary of Unaudited Quarterly Financial Information</ShortName>
      <MenuCategory>Notes</MenuCategory>
      <Position>18</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R19.htm</HtmlFileName>
      <LongName>2202201 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies (Policies)</ShortName>
      <MenuCategory>Policies</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies</ParentRole>
      <Position>19</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R20.htm</HtmlFileName>
      <LongName>2303301 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies</ParentRole>
      <Position>20</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R21.htm</HtmlFileName>
      <LongName>2313302 - Disclosure - Business Combinations (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BusinessCombinationsTables</Role>
      <ShortName>Business Combinations (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BusinessCombinations</ParentRole>
      <Position>21</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R22.htm</HtmlFileName>
      <LongName>2318303 - Disclosure - Fair Value Measurement (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/FairValueMeasurementTables</Role>
      <ShortName>Fair Value Measurement (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/FairValueMeasurement</ParentRole>
      <Position>22</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R23.htm</HtmlFileName>
      <LongName>2322304 - Disclosure - Lease Obligations (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/LeaseObligationsTables</Role>
      <ShortName>Lease Obligations (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/LeaseObligations</ParentRole>
      <Position>23</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R24.htm</HtmlFileName>
      <LongName>2326305 - Disclosure - Convertible Senior Notes (Tables)</LongName>
      <ReportType>Notes</ReportType>
      <Role>http://www.ligand.com/role/ConvertibleSeniorNotesTables</Role>
      <ShortName>Convertible Senior Notes (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/ConvertibleSeniorNotes</ParentRole>
      <Position>24</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R25.htm</HtmlFileName>
      <LongName>2330306 - Disclosure - Balance Sheet Account Details (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsTables</Role>
      <ShortName>Balance Sheet Account Details (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BalanceSheetAccountDetails</ParentRole>
      <Position>25</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R26.htm</HtmlFileName>
      <LongName>2338307 - Disclosure - Stockholders' Equity (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityTables</Role>
      <ShortName>Stockholders' Equity (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/StockholdersEquity</ParentRole>
      <Position>26</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R27.htm</HtmlFileName>
      <LongName>2347308 - Disclosure - Income Taxes (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesTables</Role>
      <ShortName>Income Taxes (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/IncomeTaxes</ParentRole>
      <Position>27</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R28.htm</HtmlFileName>
      <LongName>2354309 - Disclosure - Summary of Unaudited Quarterly Financial Information (Tables)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables</Role>
      <ShortName>Summary of Unaudited Quarterly Financial Information (Tables)</ShortName>
      <MenuCategory>Tables</MenuCategory>
      <ParentRole>http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation</ParentRole>
      <Position>28</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R29.htm</HtmlFileName>
      <LongName>2404401 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables</ParentRole>
      <Position>29</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R30.htm</HtmlFileName>
      <LongName>2405402 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>30</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R31.htm</HtmlFileName>
      <LongName>2406403 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>31</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R32.htm</HtmlFileName>
      <LongName>2407404 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>32</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R33.htm</HtmlFileName>
      <LongName>2408405 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <ParentRole>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables</ParentRole>
      <Position>33</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R34.htm</HtmlFileName>
      <LongName>2409406 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails</Role>
      <ShortName>Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>34</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R35.htm</HtmlFileName>
      <LongName>2411407 - Disclosure - Investment in Viking - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/InvestmentinVikingNarrativeDetails</Role>
      <ShortName>Investment in Viking - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>35</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R36.htm</HtmlFileName>
      <LongName>2414408 - Disclosure - Business Combinations - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BusinessCombinationsNarrativeDetails</Role>
      <ShortName>Business Combinations - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>36</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R37.htm</HtmlFileName>
      <LongName>2415409 - Disclosure - Business Combinations - Assets Acquired and Liabilities Assumed (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails</Role>
      <ShortName>Business Combinations - Assets Acquired and Liabilities Assumed (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>37</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R38.htm</HtmlFileName>
      <LongName>2416410 - Disclosure - Business Combinations - Consideration Transferred (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails</Role>
      <ShortName>Business Combinations - Consideration Transferred (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>38</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R39.htm</HtmlFileName>
      <LongName>2419411 - Disclosure - Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails</Role>
      <ShortName>Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>39</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R40.htm</HtmlFileName>
      <LongName>2420412 - Disclosure - Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails</Role>
      <ShortName>Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>40</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R41.htm</HtmlFileName>
      <LongName>2423413 - Disclosure - Lease Obligations - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/LeaseObligationsNarrativeDetails</Role>
      <ShortName>Lease Obligations - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>41</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R42.htm</HtmlFileName>
      <LongName>2424414 - Disclosure - Lease Obligations - Operating Lease Obligations and Payments (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails</Role>
      <ShortName>Lease Obligations - Operating Lease Obligations and Payments (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>42</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R43.htm</HtmlFileName>
      <LongName>2427415 - Disclosure - Convertible Senior Notes - Narrative (Details)</LongName>
      <ReportType>Notes</ReportType>
      <Role>http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails</Role>
      <ShortName>Convertible Senior Notes - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>43</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R44.htm</HtmlFileName>
      <LongName>2428416 - Disclosure - Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details)</LongName>
      <ReportType>Notes</ReportType>
      <Role>http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails</Role>
      <ShortName>Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>44</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R45.htm</HtmlFileName>
      <LongName>2431417 - Disclosure - Balance Sheet Account Details - Investment Categories (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails</Role>
      <ShortName>Balance Sheet Account Details - Investment Categories (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>45</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R46.htm</HtmlFileName>
      <LongName>2432418 - Disclosure - Balance Sheet Account Details - Other Current Assets (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails</Role>
      <ShortName>Balance Sheet Account Details - Other Current Assets (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>46</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R47.htm</HtmlFileName>
      <LongName>2433419 - Disclosure - Balance Sheet Account Details - Property and Equipment (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails</Role>
      <ShortName>Balance Sheet Account Details - Property and Equipment (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>47</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R48.htm</HtmlFileName>
      <LongName>2434420 - Disclosure - Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails</Role>
      <ShortName>Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>48</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R49.htm</HtmlFileName>
      <LongName>2435421 - Disclosure - Balance Sheet Account Details - Accrued Liabilities (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails</Role>
      <ShortName>Balance Sheet Account Details - Accrued Liabilities (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>49</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R50.htm</HtmlFileName>
      <LongName>2436422 - Disclosure - Balance Sheet Account Details - Contingent Liabilities (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails</Role>
      <ShortName>Balance Sheet Account Details - Contingent Liabilities (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>50</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R51.htm</HtmlFileName>
      <LongName>2439423 - Disclosure - Stockholders' Equity - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityNarrativeDetails</Role>
      <ShortName>Stockholders' Equity - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>51</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R52.htm</HtmlFileName>
      <LongName>2440424 - Disclosure - Stockholders' Equity - Share-Based Compensation (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails</Role>
      <ShortName>Stockholders' Equity - Share-Based Compensation (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>52</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R53.htm</HtmlFileName>
      <LongName>2441425 - Disclosure - Stockholders' Equity - Stock Option Plan Activity (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails</Role>
      <ShortName>Stockholders' Equity - Stock Option Plan Activity (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>53</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R54.htm</HtmlFileName>
      <LongName>2442426 - Disclosure - Stockholders' Equity - Breakdown of Options Outstanding (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails</Role>
      <ShortName>Stockholders' Equity - Breakdown of Options Outstanding (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>54</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R55.htm</HtmlFileName>
      <LongName>2443427 - Disclosure - Stockholders' Equity - Assumptions (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityAssumptionsDetails</Role>
      <ShortName>Stockholders' Equity - Assumptions (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>55</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R56.htm</HtmlFileName>
      <LongName>2444428 - Disclosure - Stockholders' Equity - Restricted Stock Activity (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails</Role>
      <ShortName>Stockholders' Equity - Restricted Stock Activity (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>56</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R57.htm</HtmlFileName>
      <LongName>2448429 - Disclosure - Income Taxes - Narrative (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesNarrativeDetails</Role>
      <ShortName>Income Taxes - Narrative (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>57</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R58.htm</HtmlFileName>
      <LongName>2449430 - Disclosure - Income Taxes - Components of Income Tax Expense (Benefit) (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails</Role>
      <ShortName>Income Taxes - Components of Income Tax Expense (Benefit) (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>58</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R59.htm</HtmlFileName>
      <LongName>2450431 - Disclosure - Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails</Role>
      <ShortName>Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>59</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R60.htm</HtmlFileName>
      <LongName>2451432 - Disclosure - Income Taxes - Deferred Taxes (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails</Role>
      <ShortName>Income Taxes - Deferred Taxes (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>60</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R61.htm</HtmlFileName>
      <LongName>2452433 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails</Role>
      <ShortName>Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <Position>61</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R62.htm</HtmlFileName>
      <LongName>2455434 - Disclosure - Summary of Unaudited Quarterly Financial Information - Summary (Details)</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails</Role>
      <ShortName>Summary of Unaudited Quarterly Financial Information - Summary (Details)</ShortName>
      <MenuCategory>Details</MenuCategory>
      <ParentRole>http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables</ParentRole>
      <Position>62</Position>
    </Report>
    <Report instance="lgnd-20181231.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R9999.htm</HtmlFileName>
      <LongName>Uncategorized Items - lgnd-20181231.htm</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://xbrl.sec.gov/role/uncategorizedFacts</Role>
      <ShortName>Uncategorized Items - lgnd-20181231.htm</ShortName>
      <MenuCategory>Cover</MenuCategory>
      <Position>63</Position>
    </Report>
    <Report>
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <LongName>All Reports</LongName>
      <ReportType>Book</ReportType>
      <ShortName>All Reports</ShortName>
    </Report>
  </MyReports>
  <InputFiles>
    <File doctype="10-K" original="lgnd-20181231.htm">lgnd-20181231.htm</File>
    <File>lgnd-20181231.xsd</File>
    <File>lgnd-20181231_cal.xml</File>
    <File>lgnd-20181231_def.xml</File>
    <File>lgnd-20181231_lab.xml</File>
    <File>lgnd-20181231_pre.xml</File>
    <File>lgnd123118exhibit1048-.htm</File>
    <File>lgnd123118exhibit211-n.htm</File>
    <File>lgnd123118exhibit231-n.htm</File>
    <File>lgnd123118exhibit311-n.htm</File>
    <File>lgnd123118exhibit312-n.htm</File>
    <File>lgnd123118exhibit321-n.htm</File>
  </InputFiles>
  <SupplementalFiles/>
  <BaseTaxonomies>
    <BaseTaxonomy>http://xbrl.sec.gov/dei/2018-01-31</BaseTaxonomy>
    <BaseTaxonomy>http://xbrl.sec.gov/stpr/2018-01-31</BaseTaxonomy>
    <BaseTaxonomy>http://fasb.org/us-gaap/2018-01-31</BaseTaxonomy>
    <BaseTaxonomy>http://xbrl.sec.gov/invest/2013-01-31</BaseTaxonomy>
    <BaseTaxonomy>http://fasb.org/srt/2018-01-31</BaseTaxonomy>
    <BaseTaxonomy>http://xbrl.sec.gov/country/2017-01-31</BaseTaxonomy>
  </BaseTaxonomies>
  <HasPresentationLinkbase>true</HasPresentationLinkbase>
  <HasCalculationLinkbase>true</HasCalculationLinkbase>
</FilingSummary>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>JSON
<SEQUENCE>85
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
{
 "instance": {
  "lgnd-20181231.htm": {
   "axisCustom": 1,
   "axisStandard": 41,
   "contextCount": 397,
   "dts": {
    "calculationLink": {
     "local": [
      "lgnd-20181231_cal.xml"
     ]
    },
    "definitionLink": {
     "local": [
      "lgnd-20181231_def.xml"
     ],
     "remote": [
      "http://xbrl.fasb.org/srt/2018/elts/srt-eedm1-def-2018-01-31.xml",
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-eedm-def-2018-01-31.xml"
     ]
    },
    "inline": {
     "local": [
      "lgnd-20181231.htm"
     ]
    },
    "labelLink": {
     "local": [
      "lgnd-20181231_lab.xml"
     ],
     "remote": [
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-doc-2018-01-31.xml",
      "http://xbrl.sec.gov/invest/2013/invest-doc-2013-01-31.xml",
      "https://xbrl.sec.gov/dei/2018/dei-doc-2018-01-31.xml"
     ]
    },
    "presentationLink": {
     "local": [
      "lgnd-20181231_pre.xml"
     ]
    },
    "referenceLink": {
     "remote": [
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-ref-2018-01-31.xml",
      "http://xbrl.sec.gov/invest/2013/invest-ref-2013-01-31.xml",
      "https://xbrl.sec.gov/dei/2018/dei-ref-2018-01-31.xml"
     ]
    },
    "schema": {
     "local": [
      "lgnd-20181231.xsd"
     ],
     "remote": [
      "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xl-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xlink-2003-12-31.xsd",
      "http://www.xbrl.org/2005/xbrldt-2005.xsd",
      "http://www.xbrl.org/2006/ref-2006-02-27.xsd",
      "http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd",
      "http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/deprecated-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/net-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/reference-2009-12-16.xsd",
      "http://xbrl.fasb.org/srt/2018/elts/srt-2018-01-31.xsd",
      "http://xbrl.fasb.org/srt/2018/elts/srt-roles-2018-01-31.xsd",
      "http://xbrl.fasb.org/srt/2018/elts/srt-types-2018-01-31.xsd",
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-gaap-2018-01-31.xsd",
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-parts-codification-2018-01-31.xsd",
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-roles-2018-01-31.xsd",
      "http://xbrl.fasb.org/us-gaap/2018/elts/us-types-2018-01-31.xsd",
      "http://xbrl.sec.gov/country/2017/country-2017-01-31.xsd",
      "http://xbrl.sec.gov/invest/2013/invest-2013-01-31.xsd",
      "https://xbrl.sec.gov/dei/2018/dei-2018-01-31.xsd",
      "https://xbrl.sec.gov/stpr/2018/stpr-2018-01-31.xsd"
     ]
    }
   },
   "elementCount": 774,
   "entityCount": 1,
   "hidden": {
    "http://fasb.org/us-gaap/2018-01-31": 77,
    "http://www.ligand.com/20181231": 2,
    "http://xbrl.sec.gov/dei/2018-01-31": 14,
    "total": 93
   },
   "keyCustom": 89,
   "keyStandard": 389,
   "memberCustom": 64,
   "memberStandard": 61,
   "nsprefix": "lgnd",
   "nsuri": "http://www.ligand.com/20181231",
   "report": {
    "R1": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "dei:DocumentType",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "document",
     "isDefault": "true",
     "longName": "0001001 - Document - Document and Entity Information",
     "role": "http://www.ligand.com/role/DocumentandEntityInformation",
     "shortName": "Document and Entity Information",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "dei:DocumentType",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R10": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:BusinessCombinationDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2112103 - Disclosure - Business Combinations",
     "role": "http://www.ligand.com/role/BusinessCombinations",
     "shortName": "Business Combinations",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:BusinessCombinationDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R11": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:FinancialInstrumentsDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2117104 - Disclosure - Fair Value Measurement",
     "role": "http://www.ligand.com/role/FairValueMeasurement",
     "shortName": "Fair Value Measurement",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:FinancialInstrumentsDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R12": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:LeasesOfLesseeDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2121105 - Disclosure - Lease Obligations",
     "role": "http://www.ligand.com/role/LeaseObligations",
     "shortName": "Lease Obligations",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:LeasesOfLesseeDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R13": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:DebtDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2125106 - Disclosure - Convertible Senior Notes",
     "role": "http://www.ligand.com/role/ConvertibleSeniorNotes",
     "shortName": "Convertible Senior Notes",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:DebtDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R14": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:SupplementalBalanceSheetDisclosuresTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2129107 - Disclosure - Balance Sheet Account Details",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetails",
     "shortName": "Balance Sheet Account Details",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:SupplementalBalanceSheetDisclosuresTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R15": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:StockholdersEquityNoteDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2137108 - Disclosure - Stockholders' Equity",
     "role": "http://www.ligand.com/role/StockholdersEquity",
     "shortName": "Stockholders' Equity",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:StockholdersEquityNoteDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R16": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:LegalMattersAndContingenciesTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2145109 - Disclosure - Commitments and Contingencies: Legal Proceedings",
     "role": "http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings",
     "shortName": "Commitments and Contingencies: Legal Proceedings",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:LegalMattersAndContingenciesTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R17": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:IncomeTaxDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2146110 - Disclosure - Income Taxes",
     "role": "http://www.ligand.com/role/IncomeTaxes",
     "shortName": "Income Taxes",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:IncomeTaxDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R18": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:QuarterlyFinancialInformationTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2153111 - Disclosure - Summary of Unaudited Quarterly Financial Information",
     "role": "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation",
     "shortName": "Summary of Unaudited Quarterly Financial Information",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:QuarterlyFinancialInformationTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R19": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ConsolidationPolicyTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2202201 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Policies)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies (Policies)",
     "subGroupType": "policies",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ConsolidationPolicyTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R2": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:CashAndCashEquivalentsAtCarryingValue",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1001002 - Statement - CONSOLIDATED BALANCE SHEETS",
     "role": "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS",
     "shortName": "CONSOLIDATED BALANCE SHEETS",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:CashAndCashEquivalentsAtCarryingValue",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R20": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2303301 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies (Tables)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:SchedulesOfConcentrationOfRiskByRiskFactorTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R21": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2313302 - Disclosure - Business Combinations (Tables)",
     "role": "http://www.ligand.com/role/BusinessCombinationsTables",
     "shortName": "Business Combinations (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ic90a03fb8e984ef897589ce2505086d1_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R22": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2318303 - Disclosure - Fair Value Measurement (Tables)",
     "role": "http://www.ligand.com/role/FairValueMeasurementTables",
     "shortName": "Fair Value Measurement (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R23": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2322304 - Disclosure - Lease Obligations (Tables)",
     "role": "http://www.ligand.com/role/LeaseObligationsTables",
     "shortName": "Lease Obligations (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R24": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfDebtTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2326305 - Disclosure - Convertible Senior Notes (Tables)",
     "role": "http://www.ligand.com/role/ConvertibleSeniorNotesTables",
     "shortName": "Convertible Senior Notes (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfDebtTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R25": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2330306 - Disclosure - Balance Sheet Account Details (Tables)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsTables",
     "shortName": "Balance Sheet Account Details (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R26": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2338307 - Disclosure - Stockholders' Equity (Tables)",
     "role": "http://www.ligand.com/role/StockholdersEquityTables",
     "shortName": "Stockholders' Equity (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R27": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2347308 - Disclosure - Income Taxes (Tables)",
     "role": "http://www.ligand.com/role/IncomeTaxesTables",
     "shortName": "Income Taxes (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R28": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2354309 - Disclosure - Summary of Unaudited Quarterly Financial Information (Tables)",
     "role": "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables",
     "shortName": "Summary of Unaudited Quarterly Financial Information (Tables)",
     "subGroupType": "tables",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R29": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:UnrealizedGainLossOnInvestments",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2404401 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "INF",
      "lang": null,
      "name": "us-gaap:InventoryWriteDown",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R3": {
     "firstAnchor": null,
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1002003 - Statement - CONSOLIDATED BALANCE SHEETS (Parenthetical)",
     "role": "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical",
     "shortName": "CONSOLIDATED BALANCE SHEETS (Parenthetical)",
     "subGroupType": "parenthetical",
     "uniqueAnchor": null
    },
    "R30": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231",
      "decimals": "2",
      "first": true,
      "lang": null,
      "name": "us-gaap:ConcentrationRiskPercentage1",
      "reportCount": 1,
      "unique": true,
      "unitRef": "number",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2405402 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Revenue from Significant Partners (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ia4bf7b0f978d4ad39d50b4ae9dde5b46_D20180101-20181231",
      "decimals": "2",
      "first": true,
      "lang": null,
      "name": "us-gaap:ConcentrationRiskPercentage1",
      "reportCount": 1,
      "unique": true,
      "unitRef": "number",
      "xsiNil": "false"
     }
    },
    "R31": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2406403 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Revenue by Source (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:DisaggregationOfRevenueTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i1d2a7464c56c40d39f92de328c3dd17e_D20180101-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R32": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleofCommercialLicenseRightsTableTextBlock",
       "lgnd:CommercialLicenseRightsPolicyTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id9810b34412c4c1692e219b8fa0e1127_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:FiniteLivedIntangibleAssetsGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2407404 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Commercial License Rights (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleofCommercialLicenseRightsTableTextBlock",
       "lgnd:CommercialLicenseRightsPolicyTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id9810b34412c4c1692e219b8fa0e1127_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:FiniteLivedIntangibleAssetsGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R33": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i37074bf992d247a491292198d0359ff0_I20140831",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "lgnd:ExercisePriceofConvertibleBondHedge",
      "reportCount": 1,
      "unitRef": "usdPerShare",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2408405 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Derivatives (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "ix:continuation",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id59bcc52dcb84716a983b5657976b3d8_I20180619",
      "decimals": "2",
      "lang": null,
      "name": "us-gaap:SharePrice",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usdPerShare",
      "xsiNil": "false"
     }
    },
    "R34": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:WeightedAverageNumberOfSharesOutstandingBasic",
      "reportCount": 1,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2409406 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details)",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies - Calculation of Earnings per Share (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:WeightedAverageNumberOfSharesRestrictedStock",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R35": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:ProceedsFromCollectionOfNotesReceivable",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2411407 - Disclosure - Investment in Viking - Narrative (Details)",
     "role": "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails",
     "shortName": "Investment in Viking - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i77dbc1a726434cedaf60137ef4ee8652_D20180523-20180523",
      "decimals": "-5",
      "lang": null,
      "name": "us-gaap:OtherSignificantNoncashTransactionValueOfConsiderationReceived1",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R36": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "lgnd:RevenueRoyaltytoAcquireeShareholdersPercent",
      "reportCount": 1,
      "unitRef": "number",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2414408 - Disclosure - Business Combinations - Narrative (Details)",
     "role": "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
     "shortName": "Business Combinations - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i38901eeb0e374312bb0a645919532284_D20181001-20181031",
      "decimals": "-5",
      "lang": null,
      "name": "us-gaap:PaymentsToAcquireBusinessesGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R37": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:Goodwill",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2415409 - Disclosure - Business Combinations - Assets Acquired and Liabilities Assumed (Details)",
     "role": "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
     "shortName": "Business Combinations - Assets Acquired and Liabilities Assumed (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ia38dbfb0e11c4a9a882737b3a381dc65_I20181031",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R38": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "lgnd:CashPaidtoAcquireBusiness",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2416410 - Disclosure - Business Combinations - Consideration Transferred (Details)",
     "role": "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
     "shortName": "Business Combinations - Consideration Transferred (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id9d39dc29e40466e8cff92154f8dd23e_D20171006-20171006",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "lgnd:CashPaidtoAcquireBusiness",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R39": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2419411 - Disclosure - Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)",
     "role": "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
     "shortName": "Fair Value Measurement - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "us-gaap:FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R4": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1003004 - Statement - CONSOLIDATED STATEMENTS OF OPERATIONS",
     "role": "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
     "shortName": "CONSOLIDATED STATEMENTS OF OPERATIONS",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:CostOfGoodsAndServicesSold",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R40": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2420412 - Disclosure - Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details)",
     "role": "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails",
     "shortName": "Fair Value Measurement - Reconciliation of Level 3 Financial Instruments (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R41": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "us-gaap:LeaseAndRentalExpense",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2423413 - Disclosure - Lease Obligations - Narrative (Details)",
     "role": "http://www.ligand.com/role/LeaseObligationsNarrativeDetails",
     "shortName": "Lease Obligations - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "us-gaap:LeaseAndRentalExpense",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R42": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2424414 - Disclosure - Lease Obligations - Operating Lease Obligations and Payments (Details)",
     "role": "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails",
     "shortName": "Lease Obligations - Operating Lease Obligations and Payments (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:OperatingLeasesFutureMinimumPaymentsDueCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R43": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2427415 - Disclosure - Convertible Senior Notes - Narrative (Details)",
     "role": "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
     "shortName": "Convertible Senior Notes - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i37074bf992d247a491292198d0359ff0_I20140831",
      "decimals": "INF",
      "lang": null,
      "name": "us-gaap:ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R44": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2428416 - Disclosure - Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details)",
     "role": "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
     "shortName": "Convertible Senior Notes - Equity and Liability Components of Financing Arrangements (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfDebtTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ia32e2ae420b54b08bc61c77e24a0b664_I20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:NotesPayableCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R45": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ibe5aa361660c49aa9ade65790e60db3b_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2431417 - Disclosure - Balance Sheet Account Details - Investment Categories (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails",
     "shortName": "Balance Sheet Account Details - Investment Categories (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:DebtSecuritiesAvailableForSaleTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ibe5aa361660c49aa9ade65790e60db3b_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:AvailableForSaleDebtSecuritiesAmortizedCostBasis",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R46": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfOtherCurrentAssetsTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:RestrictedCashCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2432418 - Disclosure - Balance Sheet Account Details - Other Current Assets (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails",
     "shortName": "Balance Sheet Account Details - Other Current Assets (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfOtherCurrentAssetsTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:RestrictedCashCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R47": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:PropertyPlantAndEquipmentTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:PropertyPlantAndEquipmentGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2433419 - Disclosure - Balance Sheet Account Details - Property and Equipment (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
     "shortName": "Balance Sheet Account Details - Property and Equipment (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:PropertyPlantAndEquipmentTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:PropertyPlantAndEquipmentGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R48": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:Goodwill",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2434420 - Disclosure - Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
     "shortName": "Balance Sheet Account Details - Goodwill and Other Intangible Assets (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:IntangibleAssetsNetIncludingGoodwill",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R49": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:EmployeeRelatedLiabilitiesCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2435421 - Disclosure - Balance Sheet Account Details - Accrued Liabilities (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails",
     "shortName": "Balance Sheet Account Details - Accrued Liabilities (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfAccruedLiabilitiesTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:EmployeeRelatedLiabilitiesCurrent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R5": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:NetIncomeLoss",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1004005 - Statement - CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)",
     "role": "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS",
     "shortName": "CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R50": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "lgnd:RevenueRoyaltytoAcquireeShareholdersPercent",
      "reportCount": 1,
      "unitRef": "number",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2436422 - Disclosure - Balance Sheet Account Details - Contingent Liabilities (Details)",
     "role": "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
     "shortName": "Balance Sheet Account Details - Contingent Liabilities (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i59c0e127fb46414194fa0c5be5b4ce81_D20170101-20171231",
      "decimals": "INF",
      "lang": null,
      "name": "lgnd:AdditionalRevenueRoyaltytoAcquireeShareholdersPercent",
      "reportCount": 1,
      "unique": true,
      "unitRef": "number",
      "xsiNil": "false"
     }
    },
    "R51": {
     "firstAnchor": {
      "ancestors": [
       "ix:continuation",
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:StockRepurchasedDuringPeriodShares",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2439423 - Disclosure - Stockholders' Equity - Narrative (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
     "shortName": "Stockholders' Equity - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "ix:continuation",
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "ifbd7cb0cba444ec384334a9d717a6135_D20180501-20180531",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:StockRepurchasedDuringPeriodShares",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R52": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2440424 - Disclosure - Stockholders' Equity - Share-Based Compensation (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails",
     "shortName": "Stockholders' Equity - Share-Based Compensation (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "lgnd:ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:AllocatedShareBasedCompensationExpenseNetOfTax",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R53": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber",
      "reportCount": 1,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2441425 - Disclosure - Stockholders' Equity - Stock Option Plan Activity (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails",
     "shortName": "Stockholders' Equity - Stock Option Plan Activity (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "INF",
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R54": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "icf71bbc4ad954da9bce0e233b086c8bb_I20181231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2442426 - Disclosure - Stockholders' Equity - Breakdown of Options Outstanding (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails",
     "shortName": "Stockholders' Equity - Breakdown of Options Outstanding (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "icf71bbc4ad954da9bce0e233b086c8bb_I20181231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R55": {
     "firstAnchor": null,
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2443427 - Disclosure - Stockholders' Equity - Assumptions (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails",
     "shortName": "Stockholders' Equity - Assumptions (Details)",
     "subGroupType": "details",
     "uniqueAnchor": null
    },
    "R56": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id920233585164484842655792fe0311e_I20171231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2444428 - Disclosure - Stockholders' Equity - Restricted Stock Activity (Details)",
     "role": "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails",
     "shortName": "Stockholders' Equity - Restricted Stock Activity (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id920233585164484842655792fe0311e_I20171231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R57": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2448429 - Disclosure - Income Taxes - Narrative (Details)",
     "role": "http://www.ligand.com/role/IncomeTaxesNarrativeDetails",
     "shortName": "Income Taxes - Narrative (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-5",
      "first": true,
      "lang": null,
      "name": "lgnd:TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R58": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:CurrentFederalTaxExpenseBenefit",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2449430 - Disclosure - Income Taxes - Components of Income Tax Expense (Benefit) (Details)",
     "role": "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails",
     "shortName": "Income Taxes - Components of Income Tax Expense (Benefit) (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:CurrentFederalTaxExpenseBenefit",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R59": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2450431 - Disclosure - Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)",
     "role": "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails",
     "shortName": "Income Taxes - Reconciliation of Income Tax Expense (Benefit) (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R6": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "if12b4d59cd2641ccb993432a96845435_I20151231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:SharesOutstanding",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     },
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1005006 - Statement - CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY",
     "role": "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
     "shortName": "CONSOLIDATED STATEMENT OF STOCKHOLDERS' EQUITY",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "if12b4d59cd2641ccb993432a96845435_I20151231",
      "decimals": "INF",
      "first": true,
      "lang": null,
      "name": "us-gaap:SharesOutstanding",
      "reportCount": 1,
      "unique": true,
      "unitRef": "shares",
      "xsiNil": "false"
     }
    },
    "R60": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:DeferredTaxAssetsOperatingLossCarryforwards",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2451432 - Disclosure - Income Taxes - Deferred Taxes (Details)",
     "role": "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails",
     "shortName": "Income Taxes - Deferred Taxes (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "ix:continuation",
       "div",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i87420e1b166545afb11eefa8eb1ab74c_I20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:DeferredTaxAssetsOperatingLossCarryforwards",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R61": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "if1ac2c619ec8404fb65adfdabc0cb2f7_I20171231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:UnrecognizedTaxBenefits",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2452433 - Disclosure - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)",
     "role": "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails",
     "shortName": "Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "ib4c3c6fac973483badc44a66252c9222_I20151231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:UnrecognizedTaxBenefits",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R62": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:RevenueFromContractWithCustomerExcludingAssessedTax",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2455434 - Disclosure - Summary of Unaudited Quarterly Financial Information - Summary (Details)",
     "role": "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails",
     "shortName": "Summary of Unaudited Quarterly Financial Information - Summary (Details)",
     "subGroupType": "details",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "us-gaap:ScheduleOfQuarterlyFinancialInformationTableTextBlock",
       "ix:continuation",
       "body",
       "html"
      ],
      "contextRef": "i167ff833955b42d2b9bfa5b0ca4353ea_D20181001-20181231",
      "decimals": "-3",
      "lang": null,
      "name": "us-gaap:OperatingCostsAndExpenses",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R7": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:ProfitLoss",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "statement",
     "isDefault": "false",
     "longName": "1006007 - Statement - CONSOLIDATED STATEMENTS OF CASH FLOWS",
     "role": "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
     "shortName": "CONSOLIDATED STATEMENTS OF CASH FLOWS",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:ProfitLoss",
      "reportCount": 1,
      "unique": true,
      "unitRef": "usd",
      "xsiNil": "false"
     }
    },
    "R8": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2101101 - Disclosure - Basis of Presentation and Summary of Significant Accounting Policies",
     "role": "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies",
     "shortName": "Basis of Presentation and Summary of Significant Accounting Policies",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R9": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:VariableInterestEntityDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "disclosure",
     "isDefault": "false",
     "longName": "2110102 - Disclosure - Investment in Viking",
     "role": "http://www.ligand.com/role/InvestmentinViking",
     "shortName": "Investment in Viking",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "contextRef": "id13a97144b904710b9835494780d5820_D20180101-20181231",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "us-gaap:VariableInterestEntityDisclosureTextBlock",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    },
    "R9999": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "td",
       "tr",
       "table",
       "div",
       "body",
       "html"
      ],
      "contextRef": "i56fd83bc6dc042639ae1df971a9f4d20_I20170101",
      "decimals": "-3",
      "first": true,
      "lang": null,
      "name": "us-gaap:CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption",
      "reportCount": 1,
      "unitRef": "usd",
      "xsiNil": "false"
     },
     "groupType": "",
     "isDefault": "false",
     "longName": "Uncategorized Items - lgnd-20181231.htm",
     "role": "http://xbrl.sec.gov/role/uncategorizedFacts",
     "shortName": "Uncategorized Items - lgnd-20181231.htm",
     "subGroupType": "",
     "uniqueAnchor": null
    }
   },
   "segmentCount": 129,
   "tag": {
    "country_GB": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "UNITED KINGDOM",
        "terseLabel": "United Kingdom"
       }
      }
     },
     "localname": "GB",
     "nsuri": "http://xbrl.sec.gov/country/2017-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "dei_AmendmentFlag": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "If the value is true, then the document is an amendment to previously-filed/accepted document.",
        "label": "Amendment Flag",
        "terseLabel": "Amendment Flag"
       }
      }
     },
     "localname": "AmendmentFlag",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_CurrentFiscalYearEndDate": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "End date of current fiscal year in the format --MM-DD.",
        "label": "Current Fiscal Year End Date",
        "terseLabel": "Current Fiscal Year End Date"
       }
      }
     },
     "localname": "CurrentFiscalYearEndDate",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "gMonthDayItemType"
    },
    "dei_DocumentFiscalPeriodFocus": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This is focus fiscal period of the document report. For a first quarter 2006 quarterly report, which may also provide financial information from prior periods, the first fiscal quarter should be given as the fiscal period focus. Values: FY, Q1, Q2, Q3, Q4, H1, H2, M9, T1, T2, T3, M8, CY.",
        "label": "Document Fiscal Period Focus",
        "terseLabel": "Document Fiscal Period Focus"
       }
      }
     },
     "localname": "DocumentFiscalPeriodFocus",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "fiscalPeriodItemType"
    },
    "dei_DocumentFiscalYearFocus": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This is focus fiscal year of the document report in CCYY format. For a 2006 annual report, which may also provide financial information from prior periods, fiscal 2006 should be given as the fiscal year focus. Example: 2006.",
        "label": "Document Fiscal Year Focus",
        "terseLabel": "Document Fiscal Year Focus"
       }
      }
     },
     "localname": "DocumentFiscalYearFocus",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "gYearItemType"
    },
    "dei_DocumentPeriodEndDate": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The end date of the period reflected on the cover page if a periodic report. For all other reports and registration statements containing historical data, it is the date up through which that historical data is presented.  If there is no historical data in the report, use the filing date. The format of the date is CCYY-MM-DD.",
        "label": "Document Period End Date",
        "terseLabel": "Document Period End Date"
       }
      }
     },
     "localname": "DocumentPeriodEndDate",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "dateItemType"
    },
    "dei_DocumentType": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.",
        "label": "Document Type",
        "terseLabel": "Document Type"
       }
      }
     },
     "localname": "DocumentType",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "submissionTypeItemType"
    },
    "dei_EntityCentralIndexKey": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.",
        "label": "Entity Central Index Key",
        "terseLabel": "Entity Central Index Key"
       }
      }
     },
     "localname": "EntityCentralIndexKey",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "centralIndexKeyItemType"
    },
    "dei_EntityCommonStockSharesOutstanding": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate number of shares or other units outstanding of each of registrant's classes of capital or common stock or other ownership interests, if and as stated on cover of related periodic report. Where multiple classes or units exist define each class/interest by adding class of stock items such as Common Class A [Member], Common Class B [Member] or Partnership Interest [Member] onto the Instrument [Domain] of the Entity Listings, Instrument.",
        "label": "Entity Common Stock, Shares Outstanding",
        "terseLabel": "Entity Common Stock, Shares Outstanding"
       }
      }
     },
     "localname": "EntityCommonStockSharesOutstanding",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "sharesItemType"
    },
    "dei_EntityCurrentReportingStatus": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate 'Yes' or 'No' whether registrants (1) have filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that registrants were required to file such reports), and (2) have been subject to such filing requirements for the past 90 days. This information should be based on the registrant's current or most recent filing containing the related disclosure.",
        "label": "Entity Current Reporting Status",
        "terseLabel": "Entity Current Reporting Status"
       }
      }
     },
     "localname": "EntityCurrentReportingStatus",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "yesNoItemType"
    },
    "dei_EntityDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "All the names of the entities being reported upon in a document. Any legal structure used to conduct activities or to hold assets. Some examples of such structures are corporations, partnerships, limited liability companies, grantor trusts, and other trusts. This item does not include business and geographical segments which are included in the geographical or business segments domains.",
        "label": "Entity [Domain]",
        "terseLabel": "Entity [Domain]"
       }
      }
     },
     "localname": "EntityDomain",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "dei_EntityEmergingGrowthCompany": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate if registrant meets the emerging growth company criteria.",
        "label": "Entity Emerging Growth Company",
        "terseLabel": "Entity Emerging Growth Company"
       }
      }
     },
     "localname": "EntityEmergingGrowthCompany",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_EntityFilerCategory": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate whether the registrant is one of the following: (1) Large Accelerated Filer, (2) Accelerated Filer, (3) Non-accelerated Filer, (4) Smaller Reporting Company (Non-accelerated), (5) Smaller Reporting Accelerated Filer or (6) Smaller Reporting Company and Large Accelerated Filer. Definitions of these categories are stated in Rule 12b-2 of the Exchange Act. This information should be based on the registrant's current or most recent filing containing the related disclosure.",
        "label": "Entity Filer Category",
        "terseLabel": "Entity Filer Category"
       }
      }
     },
     "localname": "EntityFilerCategory",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "filerCategoryItemType"
    },
    "dei_EntityPublicFloat": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "State aggregate market value of voting and non-voting common equity held by non-affiliates computed by reference to price at which the common equity was last sold, or average bid and asked price of such common equity, as of the last business day of registrant's most recently completed second fiscal quarter. The public float should be reported on the cover page of the registrants form 10K.",
        "label": "Entity Public Float",
        "terseLabel": "Entity Public Float"
       }
      }
     },
     "localname": "EntityPublicFloat",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "monetaryItemType"
    },
    "dei_EntityRegistrantName": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.",
        "label": "Entity Registrant Name",
        "terseLabel": "Entity Registrant Name"
       }
      }
     },
     "localname": "EntityRegistrantName",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityShellCompany": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate if company meets the shell company criteria: a company with no or nominal operations, and with no or nominal assets or assets consisting solely of cash and cash equivalents.",
        "label": "Entity Shell Company",
        "terseLabel": "Entity Shell Company"
       }
      }
     },
     "localname": "EntityShellCompany",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_EntitySmallBusiness": {
     "auth_ref": [
      "r519"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicates that the company is a smaller reporting company with both a public float and revenues of less than $75 million.",
        "label": "Entity Small Business",
        "terseLabel": "Entity Small Business"
       }
      }
     },
     "localname": "EntitySmallBusiness",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_EntityVoluntaryFilers": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate 'Yes' or 'No' if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act.",
        "label": "Entity Voluntary Filers",
        "terseLabel": "Entity Voluntary Filers"
       }
      }
     },
     "localname": "EntityVoluntaryFilers",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "yesNoItemType"
    },
    "dei_EntityWellKnownSeasonedIssuer": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Indicate 'Yes' or 'No' if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Is used on Form Type: 10-K, 10-Q, 8-K, 20-F, 6-K, 10-K/A, 10-Q/A, 20-F/A, 6-K/A, N-CSR, N-Q, N-1A.",
        "label": "Entity Well-known Seasoned Issuer",
        "terseLabel": "Entity Well-Known Seasoned Issuer"
       }
      }
     },
     "localname": "EntityWellKnownSeasonedIssuer",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/DocumentandEntityInformation"
     ],
     "xbrltype": "yesNoItemType"
    },
    "dei_LegalEntityAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The set of legal entities associated with a report.",
        "label": "Legal Entity [Axis]",
        "terseLabel": "Legal Entity [Axis]"
       }
      }
     },
     "localname": "LegalEntityAxis",
     "nsuri": "http://xbrl.sec.gov/dei/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "invest_InvestmentWarrantsExercisePrice": {
     "auth_ref": [
      "r520"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise price of the warrants.",
        "label": "Investment Warrants, Exercise Price",
        "terseLabel": "Exercise price, warrants (USD per share)"
       }
      }
     },
     "localname": "InvestmentWarrantsExercisePrice",
     "nsuri": "http://xbrl.sec.gov/invest/2013-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "lgnd_AccruedInventoryPurchases": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accrued Inventory Purchases",
        "label": "Accrued Inventory Purchases",
        "terseLabel": "Accrued inventory purchases"
       }
      }
     },
     "localname": "AccruedInventoryPurchases",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AccruedSalesReturns": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 6.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accrued Sales Returns",
        "label": "Accrued Sales Returns",
        "terseLabel": "Return reserve"
       }
      }
     },
     "localname": "AccruedSalesReturns",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AccruedStockRepurchases": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accrued Stock Repurchases",
        "label": "Accrued Stock Repurchases",
        "terseLabel": "Payments due to broker for share repurchase"
       }
      }
     },
     "localname": "AccruedStockRepurchases",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AcquiredInProcessResearchAndDevelopmentMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Acquired in process research and development.",
        "label": "Acquired In Process Research And Development [Member]",
        "verboseLabel": "IPR&amp;D"
       }
      }
     },
     "localname": "AcquiredInProcessResearchAndDevelopmentMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_AdditionalRevenueRoyaltytoAcquireeShareholdersPercent": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additional Revenue Royalty to Acquiree Shareholders, Percent",
        "label": "Additional Revenue Royalty to Acquiree Shareholders, Percent",
        "terseLabel": "Additional revenue royalty payable when higher threshold of Cydex-related revenue met (percent)"
       }
      }
     },
     "localname": "AdditionalRevenueRoyaltytoAcquireeShareholdersPercent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_AdditionalRoyaltiesReceivableUnderSalesbasedMilestones": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additional Royalties Receivable Under Sales-based Milestones",
        "label": "Additional Royalties Receivable Under Sales-based Milestones",
        "terseLabel": "Additional royalties receivable under sales-based milestones"
       }
      }
     },
     "localname": "AdditionalRoyaltiesReceivableUnderSalesbasedMilestones",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, Foreign Currency Translation Adjustment",
        "label": "Adjustments to Additional Paid in Capital, Foreign Currency Translation Adjustment",
        "terseLabel": "Foreign currency translation adjustment"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalForeignCurrencyTranslationAdjustment",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, (Gain) Loss on Repurchase of Warrants",
        "label": "Adjustments to Additional Paid in Capital, (Gain) Loss on Repurchase of Warrants",
        "terseLabel": "Loss on repurchase of warrants"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalGainLossOnRepurchaseOfWarrants",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, Loss on Settlement of Convertible Senior Notes",
        "label": "Adjustments to Additional Paid in Capital, Loss on Settlement of Convertible Senior Notes",
        "terseLabel": "Loss on settlement of Notes"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalLossOnSettlementOfConvertibleSeniorNotes",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, Tax Effect of Convertible Senior Notes Transactions",
        "label": "Adjustments to Additional Paid in Capital, Tax Effect of Convertible Senior Notes Transactions",
        "negatedLabel": "Tax effect for Notes transactions"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalTaxEffectOfConvertibleSeniorNotesTransactions",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, Warrants Repurchased",
        "label": "Adjustments to Additional Paid in Capital, Warrants Repurchased",
        "negatedLabel": "Warrant repurchase"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalWarrantsRepurchased",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AdjustmentsToAdditionalPaidInCapitalWarrantsSettled": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustments to Additional Paid in Capital, Warrants Settled",
        "label": "Adjustments to Additional Paid in Capital, Warrants Settled",
        "terseLabel": "Deduction to additional paid-in-capital for warrants settled"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalWarrantsSettled",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_AllowanceForDoubtfulAccountsPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Allowance for doubtful accounts.",
        "label": "Allowance For Doubtful Accounts [Policy Text Block]",
        "verboseLabel": "Accounts Receivable"
       }
      }
     },
     "localname": "AllowanceForDoubtfulAccountsPolicyTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_AmendedESPPMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amended ESPP [Member]",
        "label": "Amended ESPP [Member]",
        "terseLabel": "Amended ESPP"
       }
      }
     },
     "localname": "AmendedESPPMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_AziyoMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Aziyo [Member]",
        "label": "Aziyo [Member]",
        "terseLabel": "Aziyo"
       }
      }
     },
     "localname": "AziyoMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_AziyoandCorMatrixMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Aziyo and CorMatrix [Member]",
        "label": "Aziyo and CorMatrix [Member]",
        "terseLabel": "Aziyo &amp; CorMatrix"
       }
      }
     },
     "localname": "AziyoandCorMatrixMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_BasisOfPresentationLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Basis of presentation.",
        "label": "Basis of Presentation [Line Items]",
        "terseLabel": "Basis of Presentation [Line Items]"
       }
      }
     },
     "localname": "BasisOfPresentationLineItems",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_BasisOfPresentationTable": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Basis of Presentation.",
        "label": "Basis of Presentation [Table]",
        "terseLabel": "Basis of Presentation [Table]"
       }
      }
     },
     "localname": "BasisOfPresentationTable",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_BioscienceandTechnologyBusinessCenterLawrenceKSMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Bioscience and Technology Business Center - Lawrence, KS [Member]",
        "label": "Bioscience and Technology Business Center - Lawrence, KS [Member]",
        "terseLabel": "Bioscience and Technology Business Center-Lawrence, KS"
       }
      }
     },
     "localname": "BioscienceandTechnologyBusinessCenterLawrenceKSMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business Acquisition Contingent Consideration Potential Cash Payment Additions",
        "label": "Business Acquisition Contingent Consideration Potential Cash Payment Additions",
        "terseLabel": "Additions"
       }
      }
     },
     "localname": "BusinessAcquisitionContingentConsiderationPotentialCashPaymentAdditions",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business acquisition contingent consideration, potential cash payment at end of period.",
        "label": "Business Acquisition Contingent Consideration Potential Cash Payment At End Of Period",
        "periodEndLabel": "Commercial rights at end of period",
        "periodStartLabel": "Commercial rights at beginning of period"
       }
      }
     },
     "localname": "BusinessAcquisitionContingentConsiderationPotentialCashPaymentAtEndOfPeriod",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business Combination, Assumptions Used Estimated Future Cash Flows, Average Discount Rate",
        "label": "Business Combination, Assumptions Used Estimated Future Cash Flows, Average Discount Rate",
        "terseLabel": "Average cash flow discount rate (as a percent)"
       }
      }
     },
     "localname": "BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsAverageDiscountRate",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business Combination, Assumptions Used Estimated Future Cash Flows, Discount Rate",
        "label": "Business Combination, Assumptions Used Estimated Future Cash Flows, Discount Rate",
        "terseLabel": "Projected cash flow discount rate (as a percent)"
       }
      }
     },
     "localname": "BusinessCombinationAssumptionsUsedEstimatedFutureCashFlowsDiscountRate",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Restricted Cash",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Restricted Cash",
        "terseLabel": "Restricted cash"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedRestrictedCash",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 10.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Income Tax Receivables",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Income Tax Receivables",
        "terseLabel": "Income tax receivable"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredandLiabilitiesAssumedCurrentAssetsIncomeTaxReceivables",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "California and New Jersey Research Tax Credit Carryforward [Member]",
        "label": "California and New Jersey Research Tax Credit Carryforward [Member]",
        "terseLabel": "California and New Jersey Research Tax Credit Carryforward"
       }
      }
     },
     "localname": "CaliforniaAndNewJerseyResearchTaxCreditCarryforwardMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cash, Cash Equivalents, and Short-term Investments [Policy Text Block]",
        "label": "Cash, Cash Equivalents, and Short-term Investments [Policy Text Block]",
        "verboseLabel": "Cash Equivalents &amp; Short Term Investments"
       }
      }
     },
     "localname": "CashCashEquivalentsandShorttermInvestmentsPolicyTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_CashPaidtoAcquireBusiness": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cash Paid to Acquire Business",
        "label": "Cash Paid to Acquire Business",
        "terseLabel": "Cash paid to Crystal shareholders"
       }
      }
     },
     "localname": "CashPaidtoAcquireBusiness",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_CashPayable": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cash Payable",
        "label": "Cash Payable",
        "terseLabel": "Cash payable to Crystal Shareholders"
       }
      }
     },
     "localname": "CashPayable",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ChangeInDerivativeAssetAndLiabilityFairValue": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 18.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Change in Derivative Asset and Liability Fair Value",
        "label": "Change in Derivative Asset and Liability Fair Value",
        "terseLabel": "Change in derivative asset and liability fair value"
       }
      }
     },
     "localname": "ChangeInDerivativeAssetAndLiabilityFairValue",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_CommercialLicenseRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 6.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Commercial License Rights",
        "label": "Commercial License Rights",
        "terseLabel": "Commercial license rights"
       }
      }
     },
     "localname": "CommercialLicenseRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_CommercialLicenseRightsPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Commercial License Rights [Policy Text Block]",
        "label": "Commercial License Rights [Policy Text Block]",
        "terseLabel": "Commercial license rights"
       }
      }
     },
     "localname": "CommercialLicenseRightsPolicyTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_ComputerEquipmentAndSoftwareMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Computer equipment and software.",
        "label": "Computer Equipment And Software [Member]",
        "verboseLabel": "Computer equipment and software"
       }
      }
     },
     "localname": "ComputerEquipmentAndSoftwareMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ContingentLiabilityRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contingent Liability [Roll Forward]",
        "label": "Contingent Liability [Roll Forward]",
        "terseLabel": "Contingent Liability [Roll Forward]"
       }
      }
     },
     "localname": "ContingentLiabilityRollForward",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Convertible Notes Receivable, Fair Value, Period Increase (Decrease)",
        "label": "Convertible Notes Receivable, Fair Value, Period Increase (Decrease)",
        "terseLabel": "Increase (decrease) in notes receivable fair value"
       }
      }
     },
     "localname": "ConvertibleNotesReceivableFairValuePeriodIncreaseDecrease",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ConvertibleSeniorNotes2019Member": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Convertible Senior Notes, 2019 [Member]",
        "label": "Convertible Senior Notes, 2019 [Member]",
        "terseLabel": "2019 Convertible Senior Notes"
       }
      }
     },
     "localname": "ConvertibleSeniorNotes2019Member",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ConvertibleSeniorNotes2023Member": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Convertible Senior Notes, 2023",
        "label": "Convertible Senior Notes, 2023 [Member]",
        "terseLabel": "2023 Convertible Senior Notes"
       }
      }
     },
     "localname": "ConvertibleSeniorNotes2023Member",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CorMatrixMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "CorMatrix [Member]",
        "label": "CorMatrix [Member]",
        "terseLabel": "CorMatrix"
       }
      }
     },
     "localname": "CorMatrixMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CorporateHeadquartersSanDiegoCAMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Corporate Headquarters - San Diego, CA [Member]",
        "label": "Corporate Headquarters - San Diego, CA [Member]",
        "terseLabel": "Corporate headquarters-San Diego, CA"
       }
      }
     },
     "localname": "CorporateHeadquartersSanDiegoCAMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CorporateShareRepurchaseAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Corporate Share Repurchase [Abstract]",
        "label": "Corporate Share Repurchase [Abstract]",
        "terseLabel": "Corporate Share Repurchase"
       }
      }
     },
     "localname": "CorporateShareRepurchaseAbstract",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_CrystalMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Crystal [Member]",
        "label": "Crystal [Member]",
        "terseLabel": "Crystal"
       }
      }
     },
     "localname": "CrystalMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CurrentPortionOfLiabilityForContingentValueRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Current portion of liability for contingent value rights.",
        "label": "Current Portion of Liability for Contingent Value Rights",
        "terseLabel": "Current contingent liabilities"
       }
      }
     },
     "localname": "CurrentPortionOfLiabilityForContingentValueRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_CydexMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cydex [Member]",
        "label": "Cydex [Member]",
        "terseLabel": "Cydex"
       }
      }
     },
     "localname": "CydexMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CydexPharmaceuticalsIncMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cydex Pharmaceuticals, Inc.",
        "label": "Cydex Pharmaceuticals, Inc [Member]",
        "verboseLabel": "Cydex"
       }
      }
     },
     "localname": "CydexPharmaceuticalsIncMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_CydexandCrystalMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cydex and Crystal [Member]",
        "label": "Cydex and Crystal [Member]",
        "terseLabel": "Cydex and Crystal"
       }
      }
     },
     "localname": "CydexandCrystalMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Debt Instrument, Convertible, Increase (Decrease) If-Converted Value in Excess of Principal",
        "label": "Debt Instrument, Convertible, Increase (Decrease) If-Converted Value in Excess of Principal",
        "terseLabel": "Increase (decrease) in if-converted value in excess of principal"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleIncreaseDecreaseIfConvertedValueInExcessOfPrincipal",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Debt Instrument, Convertible, Maximum Threshold Percentage of Debt Trading Price Trigger",
        "label": "Debt Instrument, Convertible, Maximum Threshold Percentage of Debt Trading Price Trigger",
        "terseLabel": "Maximum threshold of debt trading price trigger (as a percent)"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleMaximumThresholdPercentageofDebtTradingPriceTrigger",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Deferred Tax Assets, Property, Plant and Equipment and Intangible Assets",
        "label": "Deferred Tax Assets, Property, Plant and Equipment and Intangible Assets",
        "terseLabel": "Fixed assets and intangibles"
       }
      }
     },
     "localname": "DeferredTaxAssetsPropertyPlantAndEquipmentAndIntangibleAssets",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_DeferredTaxLiabilitiesFairValueAdjustment": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_DeferredIncomeTaxLiabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Deferred Tax Liabilities, Fair Value Adjustment",
        "label": "Deferred Tax Liabilities, Fair Value Adjustment",
        "negatedTerseLabel": "Retrophin fair value adjustment"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesFairValueAdjustment",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_DeferredTaxLiabilitiesFiniteLivedIntangibleAssets": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_DeferredIncomeTaxLiabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Deferred Tax Liabilities, Finite-Lived Intangible Assets",
        "label": "Deferred Tax Liabilities, Finite-Lived Intangible Assets",
        "negatedTerseLabel": "Identified intangibles"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesFiniteLivedIntangibleAssets",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_DeferredIncomeTaxLiabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Deferred Tax Liabilities, Indefinite-Lived Intangible Assets",
        "label": "Deferred Tax Liabilities, Indefinite-Lived Intangible Assets",
        "negatedTerseLabel": "Identified indefinite lived intangibles"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesIndefiniteLivedIntangibleAssets",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties",
        "label": "Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties [Member]",
        "terseLabel": "Development, Regulatory, &amp; Commercial Milestones and Tiered Royalties"
       }
      }
     },
     "localname": "DevelopmentRegulatoryCommercialMilestonesAndTieredRoyaltiesMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_DocumentAndEntityInformationAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Document and entity information.",
        "label": "Document and Entity Information [Abstract]"
       }
      }
     },
     "localname": "DocumentAndEntityInformationAbstract",
     "nsuri": "http://www.ligand.com/20181231",
     "xbrltype": "stringItemType"
    },
    "lgnd_EffectiveIncomeTaxRateReconciliationChangeInDerivatives": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 10.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Effective Income Tax Rate Reconciliation, Change in Derivatives",
        "label": "Effective Income Tax Rate Reconciliation, Change in Derivatives",
        "terseLabel": "Change in derivatives"
       }
      }
     },
     "localname": "EffectiveIncomeTaxRateReconciliationChangeInDerivatives",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_EmployeeStockPurchasePlanAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Employee Stock Purchase Plan [Abstract]",
        "label": "Employee Stock Purchase Plan [Abstract]",
        "terseLabel": "Employee Stock Purchase Plan"
       }
      }
     },
     "localname": "EmployeeStockPurchasePlanAbstract",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_EquityMethodInvestmentSharesReceivedLicensingAgreement": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Equity Method Investment, Shares Received, Licensing Agreement",
        "label": "Equity Method Investment, Shares Received, Licensing Agreement",
        "terseLabel": "Shares received pursuant to MLA amendment (shares)"
       }
      }
     },
     "localname": "EquityMethodInvestmentSharesReceivedLicensingAgreement",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "lgnd_EquityReceivedinRepaymentofNoteReceivable": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Equity Received in Repayment of Note Receivable",
        "label": "Equity Received in Repayment of Note Receivable",
        "terseLabel": "Stock and warrant received for repayment of Viking notes receivable"
       }
      }
     },
     "localname": "EquityReceivedinRepaymentofNoteReceivable",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ExercisePriceRangeEightMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Eight [Member]",
        "label": "Exercise Price Range Eight [Member]",
        "terseLabel": "$101.15 - $195.91"
       }
      }
     },
     "localname": "ExercisePriceRangeEightMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeElevenMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Eleven [Member]",
        "label": "Exercise Price Range Eleven [Member]",
        "terseLabel": "$8.58 \u2013 $195.91"
       }
      }
     },
     "localname": "ExercisePriceRangeElevenMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeFiveMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Five [Member]",
        "label": "Exercise Price Range Five [Member]",
        "terseLabel": "$21.92 - $21.92"
       }
      }
     },
     "localname": "ExercisePriceRangeFiveMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeFourMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Four [Member]",
        "label": "Exercise Price Range Four [Member]",
        "terseLabel": "$16.14 - $17.88"
       }
      }
     },
     "localname": "ExercisePriceRangeFourMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeNineMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Nine [Member]",
        "label": "Exercise Price Range Nine [Member]",
        "terseLabel": "$74.42 - $74.42"
       }
      }
     },
     "localname": "ExercisePriceRangeNineMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeOneMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range One [Member]",
        "label": "Exercise Price Range One [Member]",
        "terseLabel": "$8.58 - $10.05"
       }
      }
     },
     "localname": "ExercisePriceRangeOneMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeSevenMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Seven [Member]",
        "label": "Exercise Price Range Seven [Member]",
        "terseLabel": "$63.58 - $67.53"
       }
      }
     },
     "localname": "ExercisePriceRangeSevenMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeSixMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Six [Member]",
        "label": "Exercise Price Range Six [Member]",
        "terseLabel": "$32.00 - $56.26"
       }
      }
     },
     "localname": "ExercisePriceRangeSixMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeTenMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Ten [Member]",
        "label": "Exercise Price Range Ten [Member]",
        "terseLabel": "$85.79 - $100.38"
       }
      }
     },
     "localname": "ExercisePriceRangeTenMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeThreeMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Three [Member]",
        "label": "Exercise Price Range Three [Member]",
        "terseLabel": "$14.47 - $14.47"
       }
      }
     },
     "localname": "ExercisePriceRangeThreeMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceRangeTwoMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price Range Two [Member]",
        "label": "Exercise Price Range Two [Member]",
        "terseLabel": "$10.12 - $12.81"
       }
      }
     },
     "localname": "ExercisePriceRangeTwoMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ExercisePriceofConvertibleBondHedge": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise Price of Convertible Bond Hedge",
        "label": "Exercise Price of Convertible Bond Hedge",
        "terseLabel": "Exercise price of convertible bond hedge (USD per share)"
       }
      }
     },
     "localname": "ExercisePriceofConvertibleBondHedge",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "lgnd_FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]",
        "label": "Fair Value, Assets and Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]",
        "terseLabel": "Schedule of Reconciliation of Level 3 Financial Instruments"
       }
      }
     },
     "localname": "FairValueAssetsAndLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTableTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value Adjustment, Contingent Liabilities",
        "terseLabel": "Fair value adjustments to contingent liabilities",
        "verboseLabel": "Fair Value Adjustment"
       }
      }
     },
     "localname": "FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueAdjustmentContingentLiabilities",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Fair Value of Contingent Consideration",
        "verboseLabel": "Fair value of contingent consideration"
       }
      }
     },
     "localname": "FairValueMeasurementwithUnobservableInputsReconciliationRecurringBasisLiabilityFairValueofContingentConsideration",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ForecastedCashFlowsEffectiveInterestRatePercent": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Forecasted Cash Flows, Effective Interest Rate, Percent",
        "label": "Forecasted Cash Flows, Effective Interest Rate, Percent",
        "terseLabel": "Effective interest rate of forecasted cash flows (as a percent)"
       }
      }
     },
     "localname": "ForecastedCashFlowsEffectiveInterestRatePercent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_IncomeTaxReconciliationChangeInUncertainTaxPositions": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 6.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Income Tax Reconciliation, Change in Uncertain Tax Positions",
        "label": "Income Tax Reconciliation, Change in Uncertain Tax Positions",
        "negatedTerseLabel": "Change in uncertain tax positions"
       }
      }
     },
     "localname": "IncomeTaxReconciliationChangeInUncertainTaxPositions",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_IncomeTaxReconciliationContingentValueRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Income Tax Reconciliation, Contingent Value Rights",
        "label": "Income Tax Reconciliation, Contingent Value Rights",
        "terseLabel": "Contingent liabilities"
       }
      }
     },
     "localname": "IncomeTaxReconciliationContingentValueRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_IncomeTaxReconciliationExpiredTaxCreditsResearch": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Income Tax Reconciliation, Expired Tax Credits, Research",
        "label": "Income Tax Reconciliation, Expired Tax Credits, Research",
        "terseLabel": "Research and development credits"
       }
      }
     },
     "localname": "IncomeTaxReconciliationExpiredTaxCreditsResearch",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_IncreaseDecreaseInContingentLiabilities": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 17.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Increase (Decrease) in Contingent Liabilities",
        "label": "Increase (Decrease) in Contingent Liabilities",
        "terseLabel": "Contingent liabilities"
       }
      }
     },
     "localname": "IncreaseDecreaseInContingentLiabilities",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_IncreaseDecreaseinEquityMethodInvestment": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Increase (Decrease) in Equity Method Investment",
        "label": "Increase (Decrease) in Equity Method Investment",
        "terseLabel": "Increase (decrease) in equity method investment"
       }
      }
     },
     "localname": "IncreaseDecreaseinEquityMethodInvestment",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 6.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Increase (Decrease) in Fair Value of Convertible Debt Receivable and Warrant",
        "label": "Increase (Decrease) in Fair Value of Convertible Debt Receivable and Warrant",
        "negatedTerseLabel": "Change in fair value of the convertible debt receivable from Viking and warrants"
       }
      }
     },
     "localname": "IncreaseDecreaseinFairValueofConvertibleDebtReceivableandWarrant",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_LiabilityForContingentValueRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_Liabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Liability for contingent value rights.",
        "label": "Liability for Contingent Value Rights",
        "verboseLabel": "Long-term contingent liabilities"
       }
      }
     },
     "localname": "LiabilityForContingentValueRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_LiabilityForContingentValueRightsCompanyCrystalMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Liability For Contingent Value Rights Company, Crystal [Member]",
        "label": "Liability For Contingent Value Rights Company, Crystal [Member]",
        "terseLabel": "Contingent liabilities - Crystal"
       }
      }
     },
     "localname": "LiabilityForContingentValueRightsCompanyCrystalMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LiabilityForContingentValueRightsCompanyCydexMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Liability For Contingent Value Rights Company, Cydex",
        "label": "Liability For Contingent Value Rights Company, Cydex [Member]",
        "verboseLabel": "Contingent liabilities - CyDex"
       }
      }
     },
     "localname": "LiabilityForContingentValueRightsCompanyCydexMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LiabilityForContingentValueRightsCompanyMetabasisMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Liability For Contingent Value Rights Company, Metabasis",
        "label": "Liability For Contingent Value Rights Company, Metabasis [Member]",
        "terseLabel": "Contingent liabilities - Metabasis"
       }
      }
     },
     "localname": "LiabilityForContingentValueRightsCompanyMetabasisMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Liability for Restricted Investments Owed to Former Licensees [Member]",
        "label": "Liability for Restricted Investments Owed to Former Licensees [Member]",
        "terseLabel": "Liability for restricted investments owed to former licensees"
       }
      }
     },
     "localname": "LiabilityForRestrictedInvestmentsOwedToFormerLicenseesMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LicenseFeesMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "License Fees",
        "label": "License Fees [Member]",
        "terseLabel": "License fees"
       }
      }
     },
     "localname": "LicenseFeesMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LicenseFeesMilestonesAndOtherProductOtherMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "License Fees, Milestones, and Other Product, Other",
        "label": "License Fees, Milestones, and Other Product, Other [Member]",
        "terseLabel": "Other"
       }
      }
     },
     "localname": "LicenseFeesMilestonesAndOtherProductOtherMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_LicenseFeesMilestonesandProductOtherMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "License Fees, Milestones, and Product, Other [Member]",
        "label": "License Fees, Milestones, and Product, Other [Member]",
        "terseLabel": "License fees, milestones and other revenues"
       }
      }
     },
     "localname": "LicenseFeesMilestonesandProductOtherMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MaterialSalesCaptisolMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Material Sales, Captisol [Member]",
        "label": "Material Sales, Captisol [Member]",
        "terseLabel": "Material sales"
       }
      }
     },
     "localname": "MaterialSalesCaptisolMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MaturityPeriodOfHighlyLiquidSecuritiesMaximum": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Maturity period of highly liquid securities maximum.",
        "label": "Maturity Period Of Highly Liquid Securities Maximum",
        "terseLabel": "Maturity period of cash and cash equivalents, maximum"
       }
      }
     },
     "localname": "MaturityPeriodOfHighlyLiquidSecuritiesMaximum",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "lgnd_MeasurementInputCouponRateMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement Input, Coupon Rate",
        "label": "Measurement Input, Coupon Rate [Member]",
        "terseLabel": "Annual coupon rate"
       }
      }
     },
     "localname": "MeasurementInputCouponRateMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MeasurementInputRemainingTermMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement Input, Remaining Term",
        "label": "Measurement Input, Remaining Term [Member]",
        "terseLabel": "Remaining contractual term (in years)"
       }
      }
     },
     "localname": "MeasurementInputRemainingTermMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MetabasisTherapeuticsMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Metabasis Therapeutics [Member]",
        "label": "Metabasis Therapeutics [Member]",
        "terseLabel": "Metabasis Therapeutics",
        "verboseLabel": "Metabasis"
       }
      }
     },
     "localname": "MetabasisTherapeuticsMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MilestoneMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Milestone",
        "label": "Milestone [Member]",
        "terseLabel": "Milestones"
       }
      }
     },
     "localname": "MilestoneMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_MilestonePaymentsAndRoyaltiesMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Milestone Payments and Royalties",
        "label": "Milestone Payments and Royalties [Member]",
        "terseLabel": "Milestone Payments and Royalties"
       }
      }
     },
     "localname": "MilestonePaymentsAndRoyaltiesMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_NonCashChangeInEstimatedFairValueOfContingentValueRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 2.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Non-cash change in estimated fair value of contingent value rights.",
        "label": "Non-cash change in estimated fair value of contingent value rights",
        "negatedLabel": "Change in estimated fair value of contingent liabilities"
       }
      }
     },
     "localname": "NonCashChangeInEstimatedFairValueOfContingentValueRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_NoteReceivableAmountDueUponTriggeringEvent": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Note Receivable, Amount Due Upon Triggering Event",
        "label": "Note Receivable, Amount Due Upon Triggering Event",
        "terseLabel": "Amount of loan to be repaid upon consummation of first capital financing transaction"
       }
      }
     },
     "localname": "NoteReceivableAmountDueUponTriggeringEvent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_NoteReceivableCashDueUponTriggeringEvent": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Note Receivable, Cash Due Upon Triggering Event",
        "label": "Note Receivable, Cash Due Upon Triggering Event",
        "terseLabel": "Amount of loan to be repaid in cash upon consummation of first capital financing transaction"
       }
      }
     },
     "localname": "NoteReceivableCashDueUponTriggeringEvent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_NumberOfContingentValueRightsIssued": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of Contingent Value Rights Issued",
        "label": "Number of Contingent Value Rights Issued",
        "terseLabel": "Number of contingent value rights"
       }
      }
     },
     "localname": "NumberOfContingentValueRightsIssued",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "integerItemType"
    },
    "lgnd_NumberofCollaborationAgreements": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of Collaboration Agreements",
        "label": "Number of Collaboration Agreements",
        "terseLabel": "Number of collaboration agreements"
       }
      }
     },
     "localname": "NumberofCollaborationAgreements",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "integerItemType"
    },
    "lgnd_OMTInc.Member": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "OMT, Inc. [Member]",
        "label": "OMT, Inc. [Member]",
        "terseLabel": "OMT"
       }
      }
     },
     "localname": "OMTInc.Member",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_OfficeEmeryvilleCAMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Office - Emeryville, CA [Member]",
        "label": "Office - Emeryville, CA [Member]",
        "terseLabel": "Office - Emeryville, CA"
       }
      }
     },
     "localname": "OfficeEmeryvilleCAMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_OfficeWinnershUnitedKingdomMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Office - Winnersh, United Kingdom",
        "label": "Office - Winnersh, United Kingdom [Member]",
        "terseLabel": "Office - Winnersh, United Kingdom"
       }
      }
     },
     "localname": "OfficeWinnershUnitedKingdomMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_OfficeandResearchFacilityLaJollaCAMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Office and Research Facility - La Jolla, CA [Member]",
        "label": "Office and Research Facility - La Jolla, CA [Member]",
        "terseLabel": "Office and research facility-La Jolla, CA"
       }
      }
     },
     "localname": "OfficeandResearchFacilityLaJollaCAMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 2.0,
       "parentTag": "lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due Next Twelve Months",
        "label": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due Next Twelve Months",
        "terseLabel": "Sublease payments expected to be received, Less than 1 year"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueNextTwelveMonths",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in One and Two Years",
        "label": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in One and Two Years",
        "terseLabel": "Sublease payments expected to be received, 1-2 years"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinOneandTwoYears",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in Three and Four Years",
        "label": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals, Due in Three and Four Years",
        "terseLabel": "Sublease payments expected to be received, 3-4 years"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentalsDueinThreeandFourYears",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueNet": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments Due, Net",
        "label": "Operating Leases, Future Minimum Payments Due, Net",
        "totalLabel": "Operating lease obligation, net, Total"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueNet",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments Due, Next Twelve Months, Net",
        "label": "Operating Leases, Future Minimum Payments Due, Next Twelve Months, Net",
        "totalLabel": "Operating lease obligation, Less than 1 year, net"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueNextTwelveMonthsNet",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_OperatingLeasesFutureMinimumPaymentsDue",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments, Due in One and Two Years",
        "label": "Operating Leases, Future Minimum Payments, Due in One and Two Years",
        "terseLabel": "Operating lease obligation, 1-2 years"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYears",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments, Due in One and Two Years, Net",
        "label": "Operating Leases, Future Minimum Payments, Due in One and Two Years, Net",
        "totalLabel": "Operating lease obligation, 1-2 years, net"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueinOneandTwoYearsNet",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_OperatingLeasesFutureMinimumPaymentsDue",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments, Due in Three and Four Years",
        "label": "Operating Leases, Future Minimum Payments, Due in Three and Four Years",
        "terseLabel": "Operating leases obligation, 3-4 years"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYears",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Operating Leases, Future Minimum Payments, Due in Three and Four Years, Net",
        "label": "Operating Leases, Future Minimum Payments, Due in Three and Four Years, Net",
        "totalLabel": "Operating lease obligation, 3-4 years, net"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueinThreeandFourYearsNet",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OtherAssetsCurrentOther": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_OtherAssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Other Assets, Current, Other",
        "label": "Other Assets, Current, Other",
        "terseLabel": "Other"
       }
      }
     },
     "localname": "OtherAssetsCurrentOther",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_OtherBalanceSheetDetailsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Other Balance Sheet Details [Abstract]",
        "label": "Other Balance Sheet Details [Abstract]"
       }
      }
     },
     "localname": "OtherBalanceSheetDetailsAbstract",
     "nsuri": "http://www.ligand.com/20181231",
     "xbrltype": "stringItemType"
    },
    "lgnd_OwnershipInEntityByDirectorPercentage": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Ownership in Entity by Director, Percentage",
        "label": "Ownership in Entity by Director, Percentage",
        "terseLabel": "Ownership in entity by director (as a percent)"
       }
      }
     },
     "localname": "OwnershipInEntityByDirectorPercentage",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_PalvellaTherapeuticsIncMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Palvella Therapeutics, Inc.",
        "label": "Palvella Therapeutics, Inc. [Member]",
        "terseLabel": "Palvella"
       }
      }
     },
     "localname": "PalvellaTherapeuticsIncMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_PartnerAMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Partner A [Member]",
        "label": "Partner A [Member]",
        "terseLabel": "Partner A"
       }
      }
     },
     "localname": "PartnerAMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_PartnerBMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Partner B [Member]",
        "label": "Partner B [Member]",
        "terseLabel": "Partner B"
       }
      }
     },
     "localname": "PartnerBMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_PartnerCMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Partner C [Member]",
        "label": "Partner C [Member]",
        "terseLabel": "Partner C"
       }
      }
     },
     "localname": "PartnerCMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_PaymentsToContingentValueRightHolders": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Payments to contingent value right holders",
        "label": "Payments to Contingent Value Right Holders",
        "negatedLabel": "Payments to CVR holders and other contingency payments",
        "negatedTerseLabel": "Payments"
       }
      }
     },
     "localname": "PaymentsToContingentValueRightHolders",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 10.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Payments to Contingent Value Right Holders and Other Contingency Payments, Investing Activity",
        "label": "Payments to Contingent Value Right Holders and Other Contingency Payments, Investing Activity",
        "negatedLabel": "Payments to CVR holders and other contingency payments"
       }
      }
     },
     "localname": "PaymentsToContingentValueRightHoldersAndOtherContingencyPaymentsInvestingActivity",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_PaymentsToContingentValueRightHoldersFinancingActivity": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 12.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Payments to Contingent Value Right Holders, Financing Activity",
        "label": "Payments to Contingent Value Right Holders, Financing Activity",
        "negatedLabel": "Payments to CVR holders"
       }
      }
     },
     "localname": "PaymentsToContingentValueRightHoldersFinancingActivity",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_PaymentsforConvertibleBondHedges": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Payments for Convertible Bond Hedges",
        "label": "Payments for Convertible Bond Hedges",
        "terseLabel": "Payments for convertible bond hedges"
       }
      }
     },
     "localname": "PaymentsforConvertibleBondHedges",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_Phase3ClinicalTrialMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Phase 3 Clinical Trial",
        "label": "Phase 3 Clinical Trial [Member]",
        "terseLabel": "Phase 3 Clinical Trial"
       }
      }
     },
     "localname": "Phase3ClinicalTrialMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Preclinical Study and Clinical Trial Accruals [Policy Text Block]",
        "label": "Preclinical Study and Clinical Trial Accruals [Policy Text Block]",
        "terseLabel": "Preclinical Study and Clinical Trial Accruals"
       }
      }
     },
     "localname": "PreclinicalStudyAndClinicalTrialAccrualsPolicyTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_ProductRoyaltyPercentage": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Product Royalty Percentage",
        "label": "Product Royalty Percentage",
        "terseLabel": "Product royalty (as a percent)"
       }
      }
     },
     "localname": "ProductRoyaltyPercentage",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_PurchaseOfConvertibleBondHedge": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 5.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Purchase of Convertible Bond Hedge",
        "label": "Purchase of Convertible Bond Hedge",
        "negatedLabel": "Purchase of convertible bond hedge"
       }
      }
     },
     "localname": "PurchaseOfConvertibleBondHedge",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_PurchaseforCommercialLicenseRights": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 1.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Purchase for Commercial License Rights",
        "label": "Purchase for Commercial License Rights",
        "negatedLabel": "Purchase of commercial license rights"
       }
      }
     },
     "localname": "PurchaseforCommercialLicenseRights",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_PurchaseofCommonStockMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Purchase of Common Stock [Member]",
        "label": "Purchase of Common Stock [Member]",
        "terseLabel": "Purchase of Common Stock"
       }
      }
     },
     "localname": "PurchaseofCommonStockMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ResearchFacilityCambridgeUnitedKingdomMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Research Facility - Cambridge, United Kingdom",
        "label": "Research Facility - Cambridge, United Kingdom [Member]",
        "terseLabel": "Research Facility - Cambridge, United Kingdom"
       }
      }
     },
     "localname": "ResearchFacilityCambridgeUnitedKingdomMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ResearchFacilityEmeryvilleCAMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Research Facility - Emeryville, CA [Member]",
        "label": "Research Facility - Emeryville, CA [Member]",
        "terseLabel": "Research Facility - Emeryville, CA"
       }
      }
     },
     "localname": "ResearchFacilityEmeryvilleCAMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_RevenueRecognitionMilestoneMethodMilestonePaymentReceived": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Revenue Recognition, Milestone Method Milestone Payment Received",
        "label": "Revenue Recognition, Milestone Method Milestone Payment Received",
        "terseLabel": "Milestone payment received"
       }
      }
     },
     "localname": "RevenueRecognitionMilestoneMethodMilestonePaymentReceived",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Revenue Recognition, Milestone Method Third-Party Portion of Milestone Payment Received",
        "label": "Revenue Recognition, Milestone Method Third-Party Portion of Milestone Payment Received",
        "terseLabel": "Third-party portion of milestone payment received"
       }
      }
     },
     "localname": "RevenueRecognitionMilestoneMethodThirdPartyPortionOfMilestonePaymentReceived",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_RevenueRoyaltytoAcquireeShareholdersPercent": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Revenue Royalty to Acquiree Shareholders, Percent",
        "label": "Revenue Royalty to Acquiree Shareholders, Percent",
        "terseLabel": "Revenue royalty payable on all Cydex-related revenue (as a percent)"
       }
      }
     },
     "localname": "RevenueRoyaltytoAcquireeShareholdersPercent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 16.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalties Recorded upon Adoption of New Accounting Pronouncement",
        "label": "Royalties Recorded upon Adoption of New Accounting Pronouncement",
        "terseLabel": "Royalties recorded in retained earnings upon adoption of ASC 606"
       }
      }
     },
     "localname": "RoyaltiesRecordedUponAdoptionOfNewAccountingPronouncement",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_RoyaltyAgreementExpirationPeriod": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalty Agreement, Expiration Period",
        "label": "Royalty Agreement, Expiration Period",
        "terseLabel": "Expiration period of royalty agreement"
       }
      }
     },
     "localname": "RoyaltyAgreementExpirationPeriod",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "lgnd_RoyaltyEvomelaMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalty, Evomela",
        "label": "Royalty, Evomela [Member]",
        "terseLabel": "Royalty, Evomela"
       }
      }
     },
     "localname": "RoyaltyEvomelaMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_RoyaltyKyprolisMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalty, Kyprolis",
        "label": "Royalty, Kyprolis [Member]",
        "terseLabel": "Royalty, Kyprolis"
       }
      }
     },
     "localname": "RoyaltyKyprolisMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_RoyaltyOtherMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalty, Other",
        "label": "Royalty, Other [Member]",
        "terseLabel": "Royalty, Other"
       }
      }
     },
     "localname": "RoyaltyOtherMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_RoyaltyPromactaMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Royalty, Promacta",
        "label": "Royalty, Promacta [Member]",
        "terseLabel": "Royalty, Promacta"
       }
      }
     },
     "localname": "RoyaltyPromactaMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule for share based compensation expense for awards to employees and directors.",
        "label": "Schedule For Share Based Compensation Expense for Awards to Employees and Directors [Table Text Block]",
        "terseLabel": "Schedule of Accounting for Share-Based Compensation"
       }
      }
     },
     "localname": "ScheduleForShareBasedCompensationExpenseForAwardsToEmployeesAndDirectorsTableTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule of Business Acquisitions by Acquisition, Consideration Transferred [Table Text Block]",
        "label": "Schedule of Business Acquisitions by Acquisition, Consideration Transferred [Table Text Block]",
        "terseLabel": "Schedule of Business Acquisitions"
       }
      }
     },
     "localname": "ScheduleofBusinessAcquisitionsbyAcquisitionConsiderationTransferredTableTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_ScheduleofCommercialLicenseRightsTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule of Commercial License Rights [Table Text Block]",
        "label": "Schedule of Commercial License Rights [Table Text Block]",
        "terseLabel": "Schedule of Commercial License Rights"
       }
      }
     },
     "localname": "ScheduleofCommercialLicenseRightsTableTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_ScheduleofContingentLiabilitiesTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule of Contingent Liabilities [Table Text Block]",
        "label": "Schedule of Contingent Liabilities [Table Text Block]",
        "terseLabel": "Schedule of Contingent Liabilities"
       }
      }
     },
     "localname": "ScheduleofContingentLiabilitiesTableTextBlock",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "lgnd_SelexisMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Selexis [Member]",
        "label": "Selexis [Member]",
        "terseLabel": "Selexis"
       }
      }
     },
     "localname": "SelexisMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tax Cuts and Jobs Act of 2017, Income Tax Expense (Benefit)",
        "label": "Tax Cuts and Jobs Act of 2017, Income Tax Expense (Benefit)",
        "terseLabel": "Income tax expense (benefit) from the Tax Act"
       }
      }
     },
     "localname": "TaxCutsAndJobsActOf2017IncomeTaxExpenseBenefit",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ThresholdBusinessDaysforRepaymentofPrincipal": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold Business Days for Repayment of Principal",
        "label": "Threshold Business Days for Repayment of Principal",
        "terseLabel": "Threshold business days for repayment of principal"
       }
      }
     },
     "localname": "ThresholdBusinessDaysforRepaymentofPrincipal",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "lgnd_ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold Revenue Amount to Trigger Additional Royalty Payments",
        "label": "Threshold Revenue Amount to Trigger Additional Royalty Payments",
        "terseLabel": "Cydex-related revenue amount that triggers additional royalty payments"
       }
      }
     },
     "localname": "ThresholdRevenueAmounttoTriggerAdditionalRoyaltyPayments",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ThresholdRevenueAmounttoTriggerRoyaltyPayments": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold Revenue Amount to Trigger Royalty Payments",
        "label": "Threshold Revenue Amount to Trigger Royalty Payments",
        "terseLabel": "Cydex-related revenue amount that triggers royalty payments"
       }
      }
     },
     "localname": "ThresholdRevenueAmounttoTriggerRoyaltyPayments",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold of Revenues above $1.5 million with Four Collaboration Agreements [Member]",
        "label": "Threshold of Revenues above $1.5 million with Four Collaboration Agreements [Member]",
        "terseLabel": "Threshold of Revenues above $1.5 million with Four Collaboration Agreements"
       }
      }
     },
     "localname": "ThresholdofRevenuesabove1.5millionwithFourCollaborationAgreementsMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold of Revenues above $15 million with Three Collaboration Agreements [Member]",
        "label": "Threshold of Revenues above $15 million with Three Collaboration Agreements [Member]",
        "terseLabel": "Threshold of Revenues above $15 million with Three Collaboration Agreements"
       }
      }
     },
     "localname": "ThresholdofRevenuesabove15millionwithThreeCollaborationAgreementsMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_TwoThousandTwoStockIncentivePlanMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Two thousand two Stock Incentive Plan.",
        "label": "Two thousand Two Stock Incentive Plan [Member]",
        "terseLabel": "2002 Stock Incentive Plan"
       }
      }
     },
     "localname": "TwoThousandTwoStockIncentivePlanMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Variable Interest Entity, Qualitative or Quantitative Information, Loss Percentage Recorded",
        "label": "Variable Interest Entity, Qualitative or Quantitative Information, Loss Percentage Recorded",
        "terseLabel": "Loss recorded (as a percent)"
       }
      }
     },
     "localname": "VariableInterestEntityQualitativeorQuantitativeInformationLossPercentageRecorded",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "lgnd_VariableRateComponentAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Variable Rate Component [Axis]",
        "label": "Variable Rate Component [Axis]",
        "terseLabel": "Variable Rate Component [Axis]"
       }
      }
     },
     "localname": "VariableRateComponentAxis",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "lgnd_VariableRateComponentDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "[Domain] for Variable Rate Component [Axis]",
        "label": "Variable Rate Component [Domain]",
        "terseLabel": "Variable Rate Component [Domain]"
       }
      }
     },
     "localname": "VariableRateComponentDomain",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_VernalisMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Vernalis",
        "label": "Vernalis [Member]",
        "terseLabel": "Vernalis"
       }
      }
     },
     "localname": "VernalisMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_VestingPeriodOneMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Vesting Period One [Member]",
        "label": "Vesting Period One [Member]",
        "terseLabel": "Vest 1/8 on the six month anniversary of the date of grant"
       }
      }
     },
     "localname": "VestingPeriodOneMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_VestingPeriodTwoMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Vesting Period Two [Member]",
        "label": "Vesting Period Two [Member]",
        "terseLabel": "Vest 1/48 each month for forty-two months"
       }
      }
     },
     "localname": "VestingPeriodTwoMember",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_VikingTherapeuticsInc.Member": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Viking Therapeutics, Inc. [Member]",
        "label": "Viking Therapeutics, Inc. [Member]",
        "terseLabel": "Viking Therapeutics, Inc."
       }
      }
     },
     "localname": "VikingTherapeuticsInc.Member",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails",
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "lgnd_WarrantsCurrent": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_OtherAssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Warrants, Current",
        "label": "Warrants, Current",
        "terseLabel": "Investment in Viking warrants"
       }
      }
     },
     "localname": "WarrantsCurrent",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "lgnd_WarrantsSettled": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Warrants Settled",
        "label": "Warrants Settled",
        "terseLabel": "Warrants settled (in shares)"
       }
      }
     },
     "localname": "WarrantsSettled",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "lgnd_WorkingCapitalAdjustment": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Working Capital Adjustment",
        "label": "Working Capital Adjustment",
        "terseLabel": "Working capital adjustment"
       }
      }
     },
     "localname": "WorkingCapitalAdjustment",
     "nsuri": "http://www.ligand.com/20181231",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "srt_CounterpartyNameAxis": {
     "auth_ref": [
      "r62",
      "r128"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Counterparty Name [Axis]",
        "terseLabel": "Counterparty Name [Axis]"
       }
      }
     },
     "localname": "CounterpartyNameAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_EquityMethodInvesteeNameDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Investment, Name [Domain]",
        "terseLabel": "Investment, Name [Domain]"
       }
      }
     },
     "localname": "EquityMethodInvesteeNameDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_MajorCustomersAxis": {
     "auth_ref": [
      "r180",
      "r253",
      "r258"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Customer [Axis]",
        "terseLabel": "Customer [Axis]"
       }
      }
     },
     "localname": "MajorCustomersAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_MaximumMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Maximum [Member]",
        "terseLabel": "Maximum"
       }
      }
     },
     "localname": "MaximumMember",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_MinimumMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Minimum [Member]",
        "terseLabel": "Minimum"
       }
      }
     },
     "localname": "MinimumMember",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_NameOfMajorCustomerDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Customer [Domain]",
        "terseLabel": "Customer [Domain]"
       }
      }
     },
     "localname": "NameOfMajorCustomerDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_OwnershipAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Ownership [Axis]",
        "terseLabel": "Ownership [Axis]"
       }
      }
     },
     "localname": "OwnershipAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_OwnershipDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Ownership [Domain]",
        "terseLabel": "Ownership [Domain]"
       }
      }
     },
     "localname": "OwnershipDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_ProductOrServiceAxis": {
     "auth_ref": [
      "r178",
      "r253",
      "r256",
      "r503"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Product and Service [Axis]",
        "terseLabel": "Product and Service [Axis]"
       }
      }
     },
     "localname": "ProductOrServiceAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_ProductsAndServicesDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Product and Service [Domain]",
        "terseLabel": "Product and Service [Domain]"
       }
      }
     },
     "localname": "ProductsAndServicesDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_RangeAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Range [Axis]",
        "terseLabel": "Range [Axis]"
       }
      }
     },
     "localname": "RangeAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_RangeMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Range [Domain]",
        "terseLabel": "Range [Domain]"
       }
      }
     },
     "localname": "RangeMember",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis": {
     "auth_ref": [
      "r517"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Name of Property [Axis]",
        "terseLabel": "Name of Property [Axis]"
       }
      }
     },
     "localname": "RealEstateAndAccumulatedDepreciationDescriptionOfPropertyAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_RealEstateAndAccumulatedDepreciationNameOfPropertyDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Name of Property [Domain]",
        "terseLabel": "Name of Property [Domain]"
       }
      }
     },
     "localname": "RealEstateAndAccumulatedDepreciationNameOfPropertyDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_RepurchaseAgreementCounterpartyNameDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Counterparty Name [Domain]",
        "terseLabel": "Counterparty Name [Domain]"
       }
      }
     },
     "localname": "RepurchaseAgreementCounterpartyNameDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis": {
     "auth_ref": [
      "r194"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Investment, Name [Axis]",
        "terseLabel": "Investment, Name [Axis]"
       }
      }
     },
     "localname": "ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "srt_SegmentGeographicalDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Geographical [Domain]",
        "terseLabel": "Segment, Geographical [Domain]"
       }
      }
     },
     "localname": "SegmentGeographicalDomain",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "srt_StatementGeographicalAxis": {
     "auth_ref": [
      "r179",
      "r253",
      "r257",
      "r514",
      "r516"
     ],
     "lang": {
      "en-US": {
       "role": {
        "label": "Geographical [Axis]",
        "terseLabel": "Geographical [Axis]"
       }
      }
     },
     "localname": "StatementGeographicalAxis",
     "nsuri": "http://fasb.org/srt/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "stpr_CA": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "CALIFORNIA",
        "terseLabel": "California"
       }
      }
     },
     "localname": "CA",
     "nsuri": "http://xbrl.sec.gov/stpr/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "stpr_KS": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "KANSAS",
        "verboseLabel": "Kansas"
       }
      }
     },
     "localname": "KS",
     "nsuri": "http://xbrl.sec.gov/stpr/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AcceleratedShareRepurchasesFinalPricePaidPerShare": {
     "auth_ref": [
      "r246"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Final price paid per share for the purchase of the targeted number of shares, determined by an average market price over a fixed period of time.",
        "label": "Accelerated Share Repurchases, Final Price Paid Per Share",
        "terseLabel": "Price per share of shares repurchased (USD per share)"
       }
      }
     },
     "localname": "AcceleratedShareRepurchasesFinalPricePaidPerShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_AccountingStandardsUpdate201409Member": {
     "auth_ref": [
      "r261"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accounting Standards Update 2014-09 Revenue from Contracts with Customers (Topic 606).",
        "label": "Accounting Standards Update 2014-09 [Member]",
        "terseLabel": "Accounting Standards Update 2014-09"
       }
      }
     },
     "localname": "AccountingStandardsUpdate201409Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AccountingStandardsUpdate201601Member": {
     "auth_ref": [
      "r425"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accounting Standards Update 2016-01 Financial Instruments-Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities.",
        "label": "Accounting Standards Update 2016-01 [Member]",
        "terseLabel": "Accounting Standards Update 2016-01"
       }
      }
     },
     "localname": "AccountingStandardsUpdate201601Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AccountingStandardsUpdate201609Member": {
     "auth_ref": [
      "r303",
      "r304",
      "r305",
      "r306",
      "r307",
      "r308",
      "r309",
      "r310",
      "r311",
      "r312"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accounting Standards Update 2016-09 Compensation - Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting.",
        "label": "Accounting Standards Update 2016-09 [Member]",
        "terseLabel": "Accounting Standards Update 2016-09"
       }
      }
     },
     "localname": "AccountingStandardsUpdate201609Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AccountingStandardsUpdate201615Member": {
     "auth_ref": [
      "r123"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accounting Standards Update 2016-15 Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments (a consensus of the FASB Emerging Issues Task Force).",
        "label": "Accounting Standards Update 2016-15 [Member]",
        "terseLabel": "Accounting Standards Update 2016-15"
       }
      }
     },
     "localname": "AccountingStandardsUpdate201615Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AccountsPayableCurrent": {
     "auth_ref": [
      "r45"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of liabilities incurred (and for which invoices have typically been received) and payable to vendors for goods and services received that are used in an entity's business. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).",
        "label": "Accounts Payable, Current",
        "verboseLabel": "Accounts payable"
       }
      }
     },
     "localname": "AccountsPayableCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments": {
     "auth_ref": [
      "r116"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 7.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The sum of the periodic adjustments of the differences between securities' face values and purchase prices that are charged against earnings. This is called accretion if the security was purchased at a discount and amortization if it was purchased at premium. As a noncash item, this element is an adjustment to net income when calculating cash provided by or used in operations using the indirect method.",
        "label": "Accretion (Amortization) of Discounts and Premiums, Investments",
        "negatedTerseLabel": "Amortization of premium (discount) on investments, net"
       }
      }
     },
     "localname": "AccretionAmortizationOfDiscountsAndPremiumsInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccruedLiabilitiesCurrent": {
     "auth_ref": [
      "r48"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      },
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of obligations incurred and payable, pertaining to costs that are statutory in nature, are incurred on contractual obligations, or accumulate over time and for which invoices have not yet been received or will not be rendered. Examples include taxes, interest, rent and utilities. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).",
        "label": "Accrued Liabilities, Current",
        "totalLabel": "Accrued liabilities",
        "verboseLabel": "Accrued liabilities"
       }
      }
     },
     "localname": "AccruedLiabilitiesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccruedProfessionalFeesCurrent": {
     "auth_ref": [
      "r15",
      "r16",
      "r48"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of obligations incurred through that date and payable for professional fees, such as for legal and accounting services received. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).",
        "label": "Accrued Professional Fees, Current",
        "terseLabel": "Legal"
       }
      }
     },
     "localname": "AccruedProfessionalFeesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccruedRoyaltiesCurrentAndNoncurrent": {
     "auth_ref": [
      "r474",
      "r496"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of obligations incurred through that date and payable for royalties.",
        "label": "Accrued Royalties",
        "terseLabel": "Royalties owed to third parties"
       }
      }
     },
     "localname": "AccruedRoyaltiesCurrentAndNoncurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccruedSalesCommissionCurrentAndNoncurrent": {
     "auth_ref": [
      "r25",
      "r27",
      "r467",
      "r490"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of obligations incurred through that date and payable for sales commissions.",
        "label": "Accrued Sales Commission",
        "terseLabel": "Amounts owed to former licensees"
       }
      }
     },
     "localname": "AccruedSalesCommissionCurrentAndNoncurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment": {
     "auth_ref": [
      "r43",
      "r219"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_PropertyPlantAndEquipmentNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.",
        "label": "Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment",
        "negatedLabel": "Less accumulated depreciation and amortization"
       }
      }
     },
     "localname": "AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax": {
     "auth_ref": [
      "r67",
      "r68",
      "r69"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_StockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accumulated change in equity from transactions and other events and circumstances from non-owner sources, net of tax effect, at period end. Excludes Net Income (Loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners. Includes foreign currency translation items, certain pension adjustments, unrealized gains and losses on certain investments in debt and equity securities, other than temporary impairment (OTTI) losses related to factors other than credit losses on available-for-sale and held-to-maturity debt securities that an entity does not intend to sell and it is not more likely than not that the entity will be required to sell before recovery of the amortized cost basis, as well as changes in the fair value of derivatives related to the effective portion of a designated cash flow hedge.",
        "label": "Accumulated Other Comprehensive Income (Loss), Net of Tax",
        "terseLabel": "Accumulated other comprehensive income (loss)"
       }
      }
     },
     "localname": "AccumulatedOtherComprehensiveIncomeLossNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AccumulatedOtherComprehensiveIncomeMember": {
     "auth_ref": [
      "r66",
      "r69",
      "r72",
      "r379"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accumulated increase (decrease) in equity from transactions and other events and circumstances from non-owner sources, attributable to the parent. Excludes net income (loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners.",
        "label": "AOCI Attributable to Parent [Member]",
        "terseLabel": "Accumulated other comprehensive income (loss)"
       }
      }
     },
     "localname": "AccumulatedOtherComprehensiveIncomeMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AdditionalPaidInCapital": {
     "auth_ref": [
      "r33"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_StockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Excess of issue price over par or stated value of the entity's capital stock and amounts received from other transactions involving the entity's stock or stockholders. Includes adjustments to additional paid in capital. Some examples of such adjustments include recording the issuance of debt with a beneficial conversion feature and certain tax consequences of equity instruments awarded to employees. Use this element for the aggregate amount of additional paid-in capital associated with common and preferred stock. For additional paid-in capital associated with only common stock, use the element additional paid in capital, common stock. For additional paid-in capital associated with only preferred stock, use the element additional paid in capital, preferred stock.",
        "label": "Additional Paid in Capital",
        "verboseLabel": "Additional paid-in capital"
       }
      }
     },
     "localname": "AdditionalPaidInCapital",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdditionalPaidInCapitalMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Excess of issue price over par or stated value of the entity's capital stock and amounts received from other transactions involving the entity's stock or stockholders.",
        "label": "Additional Paid-in Capital [Member]",
        "terseLabel": "Additional paid-in capital"
       }
      }
     },
     "localname": "AdditionalPaidInCapitalMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_AdjustmentsForNewAccountingPronouncementsAxis": {
     "auth_ref": [
      "r137"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by new accounting pronouncement.",
        "label": "Adjustments for New Accounting Pronouncements [Axis]",
        "terseLabel": "Adjustments for New Accounting Pronouncements [Axis]"
       }
      }
     },
     "localname": "AdjustmentsForNewAccountingPronouncementsAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature": {
     "auth_ref": [
      "r239",
      "r245",
      "r350"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in additional paid in capital (APIC) resulting from recognition of deferred taxes for convertible debt with a beneficial conversion feature.",
        "label": "Adjustments to Additional Paid in Capital, Convertible Debt with Conversion Feature",
        "terseLabel": "Convertible bond hedge and warrant transactions, net of tax"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalConvertibleDebtWithConversionFeature",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt": {
     "auth_ref": [
      "r231"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adjustment to additional paid in capital resulting from the recognition of convertible debt instruments as two separate components - a debt component and an equity component. This bifurcation may result in a basis difference associated with the liability component that represents a temporary difference for purposes of applying accounting for income taxes. The initial recognition of deferred taxes for the tax effect of that temporary difference is as an adjustment to additional paid in capital.",
        "label": "Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt",
        "terseLabel": "Reclassification of equity component of currently redeemable convertible notes",
        "verboseLabel": "Debt issuance costs related to the equity component of convertible debt"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalEquityComponentOfConvertibleDebt",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdjustmentsToAdditionalPaidInCapitalOther": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of other increase (decrease) in additional paid in capital (APIC).",
        "label": "Adjustments to Additional Paid in Capital, Other",
        "terseLabel": "Other tax reclassifications"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalOther",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue": {
     "auth_ref": [
      "r268",
      "r270",
      "r314",
      "r315"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase to additional paid-in capital (APIC) from recognition of equity-based compensation.",
        "label": "Adjustments to Additional Paid in Capital, Share-based Compensation, Requisite Service Period Recognition",
        "terseLabel": "Stock-based compensation"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdjustmentsToAdditionalPaidInCapitalWarrantIssued": {
     "auth_ref": [
      "r230",
      "r239",
      "r245"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase in additional paid in capital (APIC) resulting from the issuance of warrants. Includes allocation of proceeds of debt securities issued with detachable stock purchase warrants.",
        "label": "Adjustments to Additional Paid in Capital, Warrant Issued",
        "terseLabel": "Warrant derivative",
        "verboseLabel": "Value of warrants issued"
       }
      }
     },
     "localname": "AdjustmentsToAdditionalPaidInCapitalWarrantIssued",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]",
        "verboseLabel": "Adjustments to reconcile net income to net cash provided by operating activities:"
       }
      }
     },
     "localname": "AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_AllocatedShareBasedCompensationExpenseNetOfTax": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of expense, net of income tax, recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.",
        "label": "Allocated Share-based Compensation Expense, Net of Tax",
        "terseLabel": "Share-based compensation expense"
       }
      }
     },
     "localname": "AllocatedShareBasedCompensationExpenseNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AlternativeInvestmentMeasurementInput": {
     "auth_ref": [
      "r413"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of input used to measure alternative investment.",
        "label": "Alternative Investment, Measurement Input",
        "terseLabel": "Measurement input"
       }
      }
     },
     "localname": "AlternativeInvestmentMeasurementInput",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "decimalItemType"
    },
    "us-gaap_AmortizationOfFinancingCostsAndDiscounts": {
     "auth_ref": [
      "r115",
      "r433"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 8.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense attributable to debt discount (premium) and debt issuance costs.",
        "label": "Amortization of Debt Issuance Costs and Discounts",
        "terseLabel": "Amortization of debt discount and issuance fees"
       }
      }
     },
     "localname": "AmortizationOfFinancingCostsAndDiscounts",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AmortizationOfIntangibleAssets": {
     "auth_ref": [
      "r115",
      "r205",
      "r212"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate expense charged against earnings to allocate the cost of intangible assets (nonphysical assets not used in production) in a systematic and rational manner to the periods expected to benefit from such assets. As a noncash expense, this element is added back to net income when calculating cash provided by or used in operations using the indirect method.",
        "label": "Amortization of Intangible Assets",
        "verboseLabel": "Amortization expense"
       }
      }
     },
     "localname": "AmortizationOfIntangibleAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount": {
     "auth_ref": [
      "r149"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) or earnings per unit (EPU) in the future that were not included in the computation of diluted EPS or EPU because to do so would increase EPS or EPU amounts or decrease loss per share or unit amounts for the period presented.",
        "label": "Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount",
        "terseLabel": "Potentially dilutive shares excluded from calculation due to anti-dilutive effect (shares)"
       }
      }
     },
     "localname": "AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_AociIncludingPortionAttributableToNoncontrollingInterestMember": {
     "auth_ref": [
      "r66",
      "r69",
      "r72",
      "r379"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accumulated change in equity from transactions and other events and circumstances from non-owner sources, including the portion attributable to the noncontrolling interest. Excludes net income (loss), and accumulated changes in equity from transactions resulting from investments by owners and distributions to owners.",
        "label": "AOCI Including Portion Attributable to Noncontrolling Interest [Member]",
        "terseLabel": "AOCI Including Portion Attributable to Noncontrolling Interest"
       }
      }
     },
     "localname": "AociIncludingPortionAttributableToNoncontrollingInterestMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_Assets": {
     "auth_ref": [
      "r175",
      "r464",
      "r489"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Sum of the carrying amounts as of the balance sheet date of all assets that are recognized. Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.",
        "label": "Assets",
        "totalLabel": "Total assets"
       }
      }
     },
     "localname": "Assets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AssetsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Assets [Abstract]",
        "verboseLabel": "ASSETS"
       }
      }
     },
     "localname": "AssetsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_AssetsCurrent": {
     "auth_ref": [
      "r13",
      "r14",
      "r60"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Sum of the carrying amounts as of the balance sheet date of all assets that are expected to be realized in cash, sold, or consumed within one year (or the normal operating cycle, if longer). Assets are probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.",
        "label": "Assets, Current",
        "totalLabel": "Total current assets"
       }
      }
     },
     "localname": "AssetsCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AssetsCurrentAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Assets, Current [Abstract]",
        "verboseLabel": "Current assets:"
       }
      }
     },
     "localname": "AssetsCurrentAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_AssetsFairValueDisclosure": {
     "auth_ref": [
      "r409"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events.",
        "label": "Assets, Fair Value Disclosure",
        "verboseLabel": "Assets, fair value"
       }
      }
     },
     "localname": "AssetsFairValueDisclosure",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax": {
     "auth_ref": [
      "r187"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before tax, of unrealized gain in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale, Accumulated Gross Unrealized Gain, before Tax",
        "terseLabel": "Gross unrealized gains"
       }
      }
     },
     "localname": "AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax": {
     "auth_ref": [
      "r188"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before tax, of unrealized loss in accumulated other comprehensive income (AOCI) on investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale, Accumulated Gross Unrealized Loss, before Tax",
        "negatedTerseLabel": "Gross unrealized losses"
       }
      }
     },
     "localname": "AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis": {
     "auth_ref": [
      "r185"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amortized cost of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale, Amortized Cost",
        "totalLabel": "Cost"
       }
      }
     },
     "localname": "AvailableForSaleDebtSecuritiesAmortizedCostBasis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AvailableForSaleSecuritiesDebtSecurities": {
     "auth_ref": [
      "r183",
      "r186"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale",
        "terseLabel": "Estimated fair value"
       }
      }
     },
     "localname": "AvailableForSaleSecuritiesDebtSecurities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_AwardTypeAxis": {
     "auth_ref": [
      "r272",
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by award type pertaining to equity-based compensation.",
        "label": "Award Type [Axis]",
        "terseLabel": "Award Type [Axis]"
       }
      }
     },
     "localname": "AwardTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_BasisOfAccountingPolicyPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for basis of accounting, or basis of presentation, used to prepare the financial statements (for example, US Generally Accepted Accounting Principles, Other Comprehensive Basis of Accounting, IFRS).",
        "label": "Basis of Accounting, Policy [Policy Text Block]",
        "terseLabel": "Basis of Presentation"
       }
      }
     },
     "localname": "BasisOfAccountingPolicyPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_BusinessAcquisitionAcquireeDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Identification of the acquiree in a material business combination (or series of individually immaterial business combinations), which may include the name or other type of identification of the acquiree.",
        "label": "Business Acquisition, Acquiree [Domain]",
        "terseLabel": "Business Acquisition, Acquiree [Domain]"
       }
      }
     },
     "localname": "BusinessAcquisitionAcquireeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_BusinessAcquisitionAxis": {
     "auth_ref": [
      "r357",
      "r358"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by business combination or series of individually immaterial business combinations.",
        "label": "Business Acquisition [Axis]",
        "terseLabel": "Business Acquisition [Axis]"
       }
      }
     },
     "localname": "BusinessAcquisitionAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned": {
     "auth_ref": [
      "r371"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of equity interests (such as common shares, preferred shares, or partnership interest) issued or issuable to acquire the entity.",
        "label": "Business Acquisition, Equity Interest Issued or Issuable, Value Assigned",
        "terseLabel": "Total share consideration",
        "verboseLabel": "Value of share consideration"
       }
      }
     },
     "localname": "BusinessAcquisitionEquityInterestIssuedOrIssuableValueAssigned",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued": {
     "auth_ref": [
      "r371"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares of equity interests issued or issuable to acquire entity.",
        "label": "Business Acquisition, Equity Interest Issued or Issuable, Number of Shares",
        "terseLabel": "Actual number of shares issued (shares)"
       }
      }
     },
     "localname": "BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_BusinessAcquisitionLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Business Acquisition [Line Items]",
        "terseLabel": "Business Acquisition [Line Items]"
       }
      }
     },
     "localname": "BusinessAcquisitionLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_BusinessCombinationConsiderationTransferred1": {
     "auth_ref": [
      "r367",
      "r368",
      "r369"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of consideration transferred, consisting of acquisition-date fair value of assets transferred by the acquirer, liabilities incurred by the acquirer, and equity interest issued by the acquirer.",
        "label": "Business Combination, Consideration Transferred",
        "terseLabel": "Consideration transferred"
       }
      }
     },
     "localname": "BusinessCombinationConsiderationTransferred1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationDisclosureTextBlock": {
     "auth_ref": [
      "r372"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for a business combination (or series of individually immaterial business combinations) completed during the period, including background, timing, and recognized assets and liabilities. The disclosure may include leverage buyout transactions (as applicable).",
        "label": "Business Combination Disclosure [Text Block]",
        "terseLabel": "Business Combinations"
       }
      }
     },
     "localname": "BusinessCombinationDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinations"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of currency on hand as well as demand deposits with banks or financial institutions, acquired at the acquisition date. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Cash and Equivalents",
        "terseLabel": "Cash and cash equivalents"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of asset related to consideration paid in advance for costs that provide economic benefits in future periods, and amount of other assets that are expected to be realized or consumed within one year or the normal operating cycle, if longer, acquired at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Prepaid Expense and Other Assets",
        "terseLabel": "Prepaid expenses and other current assets"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsPrepaidExpenseAndOtherAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount due from customers or clients for goods or services, including trade receivables, that have been delivered or sold in the normal course of business, and amounts due from others, including related parties expected to be converted to cash, sold or exchanged within one year or the normal operating cycle, if longer, acquired at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Assets, Receivables",
        "terseLabel": "Accounts receivable"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 8.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of liabilities due within one year or within the normal operating cycle, if longer, assumed at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities",
        "negatedTerseLabel": "Current liabilities assumed"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable": {
     "auth_ref": [
      "r360"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of liabilities incurred for goods and services received that are used in an entity's business and related party payables, assumed at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Accounts Payable",
        "negatedLabel": "Accounts payable and accrued liabilities"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesAccountsPayable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 7.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred revenue expected to be recognized as such within one year or the normal operating cycle, if longer, assumed at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Current Liabilities, Deferred Revenue",
        "negatedTerseLabel": "Deferred revenue"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilitiesDeferredRevenue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities": {
     "auth_ref": [
      "r325",
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred tax liability attributable to taxable temporary differences assumed at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Deferred Tax Liabilities",
        "negatedTerseLabel": "Deferred tax liabilities, net"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles": {
     "auth_ref": [
      "r359",
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of identifiable intangible assets recognized as of the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Finite-Lived Intangibles",
        "terseLabel": "Intangible asset with finite life - core technology"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibles",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities": {
     "auth_ref": [
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 11.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of liabilities assumed at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Liabilities",
        "negatedTerseLabel": "Liabilities assumed",
        "verboseLabel": "Assumed liabilities"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet": {
     "auth_ref": [
      "r359",
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount recognized as of the acquisition date for the identifiable assets acquired in excess of (less than) the aggregate liabilities assumed.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net",
        "terseLabel": "Total consideration",
        "totalLabel": "Total consideration"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets": {
     "auth_ref": [
      "r360"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of other assets expected to be realized or consumed after one year or the normal operating cycle, if longer, acquired at the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Other Noncurrent Assets",
        "terseLabel": "Other assets"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedOtherNoncurrentAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment": {
     "auth_ref": [
      "r359",
      "r360"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 9.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of property, plant, and equipment recognized as of the acquisition date.",
        "label": "Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Property, Plant, and Equipment",
        "terseLabel": "Property and equipment, net"
       }
      }
     },
     "localname": "BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_BusinessCombinationsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Business Combinations [Abstract]"
       }
      }
     },
     "localname": "BusinessCombinationsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_BusinessCombinationsPolicy": {
     "auth_ref": [
      "r124",
      "r356"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for completed business combinations (purchase method, acquisition method or combination of entities under common control). This accounting policy may include a general discussion of the purchase method or acquisition method of accounting (including for example, the treatment accorded contingent consideration, the identification of assets and liabilities, the purchase price allocation process, how the fair values of acquired assets and liabilities are determined) and the entity's specific application thereof. An entity that acquires another entity in a leveraged buyout transaction generally discloses the accounting policy followed by the acquiring entity in determining the basis used to value its interest in the acquired entity, and the rationale for that accounting policy.",
        "label": "Business Combinations Policy [Policy Text Block]",
        "terseLabel": "Business Combinations"
       }
      }
     },
     "localname": "BusinessCombinationsPolicy",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member": {
     "auth_ref": [
      "r260"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Calculated under guidance for revenue recognition in effect prior to change to new guidance for revenue from contract with customer when using transition method for cumulative effect in period including initial date of application.",
        "label": "Calculated under Revenue Guidance in Effect before Topic 606 [Member]",
        "terseLabel": "Calculated under Revenue Guidance in Effect before Topic 606"
       }
      }
     },
     "localname": "CalculatedUnderRevenueGuidanceInEffectBeforeTopic606Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CashAndCashEquivalentsAtCarryingValue": {
     "auth_ref": [
      "r9",
      "r39",
      "r117"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Also includes short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. Excludes cash and cash equivalents within disposal group and discontinued operation.",
        "label": "Cash and Cash Equivalents, at Carrying Value",
        "verboseLabel": "Cash and cash equivalents"
       }
      }
     },
     "localname": "CashAndCashEquivalentsAtCarryingValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents": {
     "auth_ref": [
      "r107",
      "r117",
      "r122"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage. Excludes amount for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.",
        "label": "Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents",
        "periodEndLabel": "Cash, cash equivalents, and restricted cash at end of year",
        "periodStartLabel": "Cash, cash equivalents, and restricted cash at beginning of year"
       }
      }
     },
     "localname": "CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect": {
     "auth_ref": [
      "r107",
      "r427"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; excluding effect from exchange rate change. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.",
        "label": "Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Excluding Exchange Rate Effect",
        "totalLabel": "Net increase (decrease) in cash and cash equivalents"
       }
      }
     },
     "localname": "CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]",
        "terseLabel": "Supplemental schedule of non-cash investing and financing activities"
       }
      }
     },
     "localname": "CashFlowNoncashInvestingAndFinancingActivitiesDisclosureAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1": {
     "auth_ref": [
      "r133"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exercise price per share or per unit of warrants or rights outstanding.",
        "label": "Class of Warrant or Right, Exercise Price of Warrants or Rights",
        "terseLabel": "Exercise price of warrants (USD per share)",
        "verboseLabel": "Warrant exercise price (USD per share)"
       }
      }
     },
     "localname": "ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights": {
     "auth_ref": [
      "r132"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of securities into which the class of warrant or right may be converted. For example, but not limited to, 500,000 warrants may be converted into 1,000,000 shares.",
        "label": "Class of Warrant or Right, Number of Securities Called by Warrants or Rights",
        "terseLabel": "Warrants issued in public offering (shares)"
       }
      }
     },
     "localname": "ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ClassOfWarrantOrRightOutstanding": {
     "auth_ref": [
      "r134"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of warrants or rights outstanding.",
        "label": "Class of Warrant or Right, Outstanding",
        "terseLabel": "Warrants outstanding (in shares)"
       }
      }
     },
     "localname": "ClassOfWarrantOrRightOutstanding",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ClassificationOfVariableInterestEntityDomain": {
     "auth_ref": [
      "r381",
      "r382",
      "r384",
      "r385"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Categorization of Variable Interest Entities (VIE) for consolidation and (or) disclosure purposes, whether individually or in aggregate, by: (1) VIEs consolidated because the entity is the primary beneficiary, (2) VIEs not consolidated because the entity is not the primary beneficiary, and (3) VIEs or potential VIEs that are not consolidated because necessary information is not available. In general, a VIE is a corporation, partnership, trust, or any other legal structure used for business purposes that either (a) does not have equity investors with voting rights or (b) has equity investors that do not provide sufficient financial resources for the entity to support its activities. A VIE often holds financial assets, including loans or receivables, real estate or other property. A VIE may be essentially passive or it may engage in research and development or other activities on behalf of another company.",
        "label": "Variable Interest Entity, Classification [Domain]",
        "terseLabel": "Variable Interest Entity, Classification [Domain]"
       }
      }
     },
     "localname": "ClassificationOfVariableInterestEntityDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CommercialPaperMember": {
     "auth_ref": [
      "r228"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Unsecured promissory note (generally negotiable) that provides institutions with short-term funds.",
        "label": "Commercial Paper [Member]",
        "terseLabel": "Commercial paper"
       }
      }
     },
     "localname": "CommercialPaperMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CommitmentsAndContingencies": {
     "auth_ref": [
      "r54",
      "r226",
      "r475",
      "r495"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_LiabilitiesAndStockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Represents the caption on the face of the balance sheet to indicate that the entity has entered into (1) purchase or supply arrangements that will require expending a portion of its resources to meet the terms thereof, and (2) is exposed to potential losses or, less frequently, gains, arising from (a) possible claims against a company's resources due to future performance under contract terms, and (b) possible losses or likely gains from uncertainties that will ultimately be resolved when one or more future events that are deemed likely to occur do occur or fail to occur.",
        "label": "Commitments and Contingencies",
        "verboseLabel": "Commitments and contingencies"
       }
      }
     },
     "localname": "CommitmentsAndContingencies",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CommitmentsAndContingenciesDisclosureAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Commitments and Contingencies Disclosure [Abstract]"
       }
      }
     },
     "localname": "CommitmentsAndContingenciesDisclosureAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_CommonStockDividendsPerShareDeclared": {
     "auth_ref": [
      "r245"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Aggregate dividends declared during the period for each share of common stock outstanding.",
        "label": "Common Stock, Dividends, Per Share, Declared",
        "terseLabel": "Dividend declared (USD per share)"
       }
      }
     },
     "localname": "CommonStockDividendsPerShareDeclared",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_CommonStockMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Stock that is subordinate to all other stock of the issuer.",
        "label": "Common Stock [Member]",
        "terseLabel": "Common Stock"
       }
      }
     },
     "localname": "CommonStockMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CommonStockParOrStatedValuePerShare": {
     "auth_ref": [
      "r31"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Face amount or stated value per share of common stock.",
        "label": "Common Stock, Par or Stated Value Per Share",
        "verboseLabel": "Common stock, par value (USD per share)"
       }
      }
     },
     "localname": "CommonStockParOrStatedValuePerShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_CommonStockSharesAuthorized": {
     "auth_ref": [
      "r31"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The maximum number of common shares permitted to be issued by an entity's charter and bylaws.",
        "label": "Common Stock, Shares Authorized",
        "verboseLabel": "Common stock, shares authorized (shares)"
       }
      }
     },
     "localname": "CommonStockSharesAuthorized",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_CommonStockSharesIssued": {
     "auth_ref": [
      "r31"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury.",
        "label": "Common Stock, Shares, Issued",
        "verboseLabel": "Common stock, shares issued (shares)"
       }
      }
     },
     "localname": "CommonStockSharesIssued",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_CommonStockSharesOutstanding": {
     "auth_ref": [
      "r31",
      "r239"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares of common stock outstanding. Common stock represent the ownership interest in a corporation.",
        "label": "Common Stock, Shares, Outstanding",
        "terseLabel": "Common stock, shares outstanding (shares)"
       }
      }
     },
     "localname": "CommonStockSharesOutstanding",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETSParenthetical"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_CommonStockValue": {
     "auth_ref": [
      "r31"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_StockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Aggregate par or stated value of issued nonredeemable common stock (or common stock redeemable solely at the option of the issuer). This item includes treasury stock repurchased by the entity. Note: elements for number of nonredeemable common shares, par value and other disclosure concepts are in another section within stockholders' equity.",
        "label": "Common Stock, Value, Issued",
        "verboseLabel": "Common stock, $0.001 par value; 60,000,000 and 33,333,333 shares authorized; 20,765,533 and 21,148,665 shares issued and outstanding at December\u00a031, 2018 and 2017, respectively"
       }
      }
     },
     "localname": "CommonStockValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ComprehensiveIncomeNetOfTax": {
     "auth_ref": [
      "r75",
      "r77",
      "r78"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.",
        "label": "Comprehensive Income (Loss), Net of Tax, Attributable to Parent",
        "totalLabel": "Comprehensive income (loss)"
       }
      }
     },
     "localname": "ComprehensiveIncomeNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ComprehensiveIncomePolicyPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for comprehensive income.",
        "label": "Comprehensive Income, Policy [Policy Text Block]",
        "terseLabel": "Comprehensive Income (Loss)"
       }
      }
     },
     "localname": "ComprehensiveIncomePolicyPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ConcentrationRiskBenchmarkDomain": {
     "auth_ref": [
      "r164",
      "r165",
      "r421",
      "r422"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The denominator in a calculation of a disclosed concentration risk percentage.",
        "label": "Concentration Risk Benchmark [Domain]",
        "terseLabel": "Concentration Risk Benchmark [Domain]"
       }
      }
     },
     "localname": "ConcentrationRiskBenchmarkDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ConcentrationRiskByBenchmarkAxis": {
     "auth_ref": [
      "r164",
      "r165",
      "r421",
      "r422",
      "r505"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by benchmark of concentration risk.",
        "label": "Concentration Risk Benchmark [Axis]",
        "terseLabel": "Concentration Risk Benchmark [Axis]"
       }
      }
     },
     "localname": "ConcentrationRiskByBenchmarkAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ConcentrationRiskByTypeAxis": {
     "auth_ref": [
      "r164",
      "r165",
      "r421",
      "r422",
      "r505"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of concentration risk, for example, but not limited to, asset, liability, net assets, geographic, customer, employees, supplier, lender.",
        "label": "Concentration Risk Type [Axis]",
        "terseLabel": "Concentration Risk Type [Axis]"
       }
      }
     },
     "localname": "ConcentrationRiskByTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ConcentrationRiskCreditRisk": {
     "auth_ref": [
      "r159",
      "r484"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for credit risk.",
        "label": "Concentration Risk, Credit Risk, Policy [Policy Text Block]",
        "verboseLabel": "Concentrations of Business Risk"
       }
      }
     },
     "localname": "ConcentrationRiskCreditRisk",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ConcentrationRiskPercentage1": {
     "auth_ref": [
      "r164",
      "r165",
      "r421",
      "r422"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the \"benchmark\" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.",
        "label": "Concentration Risk, Percentage",
        "terseLabel": "Total revenues (as a percent)"
       }
      }
     },
     "localname": "ConcentrationRiskPercentage1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_ConcentrationRiskTypeDomain": {
     "auth_ref": [
      "r164",
      "r165",
      "r421",
      "r422"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "For an entity that discloses a concentration risk as a percentage of some financial balance or benchmark, identifies the type (for example, asset, liability, net assets, geographic, customer, employees, supplier, lender) of the concentration.",
        "label": "Concentration Risk Type [Domain]",
        "terseLabel": "Concentration Risk Type [Domain]"
       }
      }
     },
     "localname": "ConcentrationRiskTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ConsolidationPolicyTextBlock": {
     "auth_ref": [
      "r124",
      "r376",
      "r390",
      "r391"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy regarding (1) the principles it follows in consolidating or combining the separate financial statements, including the principles followed in determining the inclusion or exclusion of subsidiaries or other entities in the consolidated or combined financial statements and (2) its treatment of interests (for example, common stock, a partnership interest or other means of exerting influence) in other entities, for example consolidation or use of the equity or cost methods of accounting.  The accounting policy may also address the accounting treatment for intercompany accounts and transactions, noncontrolling interest, and the income statement treatment in consolidation for issuances of stock by a subsidiary.",
        "label": "Consolidation, Policy [Policy Text Block]",
        "verboseLabel": "Principles of Consolidation"
       }
      }
     },
     "localname": "ConsolidationPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ContractWithCustomerAssetGross": {
     "auth_ref": [
      "r248",
      "r250",
      "r254"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before allowance for credit loss, of right to consideration in exchange for good or service transferred to customer, when right is conditioned on something other than passage of time.",
        "label": "Contract with Customer, Asset, Gross",
        "terseLabel": "Gross contract asset"
       }
      }
     },
     "localname": "ContractWithCustomerAssetGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ContractWithCustomerLiabilityCurrent": {
     "auth_ref": [
      "r248",
      "r249",
      "r254"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 5.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable, classified as current.",
        "label": "Contract with Customer, Liability, Current",
        "terseLabel": "Deferred revenue"
       }
      }
     },
     "localname": "ContractWithCustomerLiabilityCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ContractWithCustomerLiabilityRevenueRecognized": {
     "auth_ref": [
      "r255"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of revenue recognized that was previously included in balance of obligation to transfer good or service to customer for which consideration from customer has been received or is due.",
        "label": "Contract with Customer, Liability, Revenue Recognized",
        "terseLabel": "Revenue recognized"
       }
      }
     },
     "localname": "ContractWithCustomerLiabilityRevenueRecognized",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ConvertibleDebtCurrent": {
     "auth_ref": [
      "r23"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The portion of the carrying value of long-term convertible debt as of the balance sheet date that is scheduled to be repaid within one year or in the normal operating cycle if longer. Convertible debt is a financial instrument which can be exchanged for a specified amount of another security, typically the entity's common stock, at the option of the issuer or the holder.",
        "label": "Convertible Debt, Current",
        "terseLabel": "2019 convertible senior notes, net"
       }
      }
     },
     "localname": "ConvertibleDebtCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ConvertibleDebtFairValueDisclosures": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value portion of borrowing which can be exchanged for a specified number of another security at the option of the issuer or the holder, for example, but not limited to, the entity's common stock.",
        "label": "Convertible Debt, Fair Value Disclosures",
        "terseLabel": "Fair value of convertible debt",
        "verboseLabel": "Fair value of convertible senior notes outstanding (Level 2)"
       }
      }
     },
     "localname": "ConvertibleDebtFairValueDisclosures",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ConvertibleDebtNoncurrent": {
     "auth_ref": [
      "r52"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_Liabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying amount of long-term convertible debt as of the balance sheet date, net of the amount due in the next twelve months or greater than the normal operating cycle, if longer. The debt is convertible into another form of financial instrument, typically the entity's common stock.",
        "label": "Convertible Debt, Noncurrent",
        "terseLabel": "Convertible debt, noncurrent",
        "verboseLabel": "2023 convertible senior notes, net"
       }
      }
     },
     "localname": "ConvertibleDebtNoncurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ConvertibleNotesPayableMember": {
     "auth_ref": [
      "r23",
      "r465",
      "r486",
      "r506"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Written promise to pay a note which can be exchanged for a specified quantity of securities (typically common stock), at the option of the issuer or the holder.",
        "label": "Convertible Notes Payable [Member]",
        "terseLabel": "Convertible Notes"
       }
      }
     },
     "localname": "ConvertibleNotesPayableMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CorporateDebtSecuritiesMember": {
     "auth_ref": [
      "r263",
      "r266"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Debt securities issued by domestic or foreign corporate business, banks and other entities with a promise of repayment.",
        "label": "Corporate Debt Securities [Member]",
        "terseLabel": "Corporate bonds"
       }
      }
     },
     "localname": "CorporateDebtSecuritiesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CostOfGoodsAndServicesSold": {
     "auth_ref": [
      "r88"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 4.0,
       "parentTag": "us-gaap_OperatingCostsAndExpenses",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate costs related to goods produced and sold and services rendered by an entity during the reporting period. This excludes costs incurred during the reporting period related to financial services rendered and other revenue generating activities.",
        "label": "Cost of Goods and Services Sold",
        "terseLabel": "Cost of material sales"
       }
      }
     },
     "localname": "CostOfGoodsAndServicesSold",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CostOfGoodsAndServicesSoldAmortization": {
     "auth_ref": [
      "r87"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 3.0,
       "parentTag": "us-gaap_OperatingCostsAndExpenses",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of expense for allocation of cost of intangible asset over its useful life directly used in production of good and rendering of service.",
        "label": "Cost, Amortization",
        "terseLabel": "Amortization of intangibles"
       }
      }
     },
     "localname": "CostOfGoodsAndServicesSoldAmortization",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of increase (decrease) to equity or (increase) decrease to net assets, resulting from the cumulative effect adjustment of a new accounting principle applied in the period of adoption.",
        "label": "Cumulative Effect of New Accounting Principle in Period of Adoption",
        "terseLabel": "Cumulative-effect adjustment from adoption of ASU"
       }
      }
     },
     "localname": "CumulativeEffectOfNewAccountingPrincipleInPeriodOfAdoption",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CurrentFederalTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r347",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_CurrentIncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current federal tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Current Federal Tax Expense (Benefit)",
        "terseLabel": "Federal"
       }
      }
     },
     "localname": "CurrentFederalTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CurrentForeignTaxExpenseBenefit": {
     "auth_ref": [
      "r131",
      "r349"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_CurrentIncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current foreign income tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Current Foreign Tax Expense (Benefit)",
        "terseLabel": "Foreign"
       }
      }
     },
     "localname": "CurrentForeignTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CurrentIncomeTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r347",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current income tax expense (benefit) pertaining to taxable income (loss) from continuing operations.",
        "label": "Current Income Tax Expense (Benefit)",
        "totalLabel": "Total Current Income Tax Benefit"
       }
      }
     },
     "localname": "CurrentIncomeTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Current Income Tax Expense (Benefit), Continuing Operations [Abstract]",
        "terseLabel": "Current expense (benefit):"
       }
      }
     },
     "localname": "CurrentIncomeTaxExpenseBenefitContinuingOperationsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_CurrentStateAndLocalTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r347",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_CurrentIncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current state and local tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Current State and Local Tax Expense (Benefit)",
        "terseLabel": "State"
       }
      }
     },
     "localname": "CurrentStateAndLocalTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_CustomerConcentrationRiskMember": {
     "auth_ref": [
      "r163"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Reflects the percentage that revenues in the period from one or more significant customers is to net revenues, as defined by the entity, such as total net revenues, product line revenues, segment revenues. The risk is the materially adverse effects of loss of a significant customer.",
        "label": "Customer Concentration Risk [Member]",
        "terseLabel": "Customer Concentration Risk"
       }
      }
     },
     "localname": "CustomerConcentrationRiskMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_CustomerRelationshipsMember": {
     "auth_ref": [
      "r363"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Customer relationship that exists between an entity and its customer, for example, but not limited to, tenant relationships.",
        "label": "Customer Relationships [Member]",
        "verboseLabel": "Customer relationships"
       }
      }
     },
     "localname": "CustomerRelationshipsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtConversionConvertedInstrumentAmount1": {
     "auth_ref": [
      "r119",
      "r121"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The value of the financial instrument(s) that the original debt is being converted into in a noncash (or part noncash) transaction. \"Part noncash\" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period.",
        "label": "Debt Conversion, Converted Instrument, Amount",
        "terseLabel": "Notices for conversion"
       }
      }
     },
     "localname": "DebtConversionConvertedInstrumentAmount1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtDisclosureAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Debt Disclosure [Abstract]"
       }
      }
     },
     "localname": "DebtDisclosureAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtDisclosureTextBlock": {
     "auth_ref": [
      "r238"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.",
        "label": "Debt Disclosure [Text Block]",
        "terseLabel": "Convertible Senior Notes"
       }
      }
     },
     "localname": "DebtDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotes"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_DebtInstrumentAxis": {
     "auth_ref": [
      "r23",
      "r25",
      "r26",
      "r465",
      "r468",
      "r486"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of debt instrument, including, but not limited to, draws against credit facilities.",
        "label": "Debt Instrument [Axis]",
        "terseLabel": "Debt Instrument [Axis]"
       }
      }
     },
     "localname": "DebtInstrumentAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtInstrumentConvertibleBeneficialConversionFeature": {
     "auth_ref": [
      "r244"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of a favorable spread to a debt holder between the amount of debt being converted and the value of the securities received upon conversion. This is an embedded conversion feature of convertible debt issued that is in-the-money at the commitment date.",
        "label": "Debt Instrument, Convertible, Beneficial Conversion Feature",
        "terseLabel": "Conversion value over the principal amount"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleBeneficialConversionFeature",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent": {
     "auth_ref": [
      "r232"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_LiabilitiesAndStockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The carrying amount of the equity component of convertible debt which may be settled in cash upon conversion.",
        "label": "Debt Instrument, Convertible, Carrying Amount of Equity Component",
        "netLabel": "Carrying value of equity component of 2023 Notes",
        "terseLabel": "Equity component of currently redeemable convertible notes (Note 6)",
        "verboseLabel": "Carrying value of equity component of convertible notes"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleCarryingAmountOfTheEquityComponent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtInstrumentConvertibleConversionPrice1": {
     "auth_ref": [
      "r233"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The price per share of the conversion feature embedded in the debt instrument.",
        "label": "Debt Instrument, Convertible, Conversion Price",
        "terseLabel": "Debt conversion price per share (USD per share)"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleConversionPrice1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_DebtInstrumentConvertibleConversionRatio1": {
     "auth_ref": [
      "r51",
      "r240",
      "r241",
      "r243"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Ratio applied to the conversion of debt instrument into equity with equity shares divided by debt principal amount.",
        "label": "Debt Instrument, Convertible, Conversion Ratio",
        "terseLabel": "Convertible debt conversion ratio"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleConversionRatio1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "pureItemType"
    },
    "us-gaap_DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal": {
     "auth_ref": [
      "r234"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount by which the convertible debt's if-converted value exceeds its principle amount at the balance sheet date, regardless of whether the instrument is currently convertible. This element applies to public companies only.",
        "label": "Debt Instrument, Convertible, If-converted Value in Excess of Principal",
        "terseLabel": "If-converted value in excess of principal"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleIfConvertedValueInExcessOfPrincipal",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtInstrumentConvertibleThresholdConsecutiveTradingDays1": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold period of specified consecutive trading days within which common stock price to conversion price of convertible debt instrument must exceed threshold percentage for specified number of trading days to trigger conversion feature.",
        "label": "Debt Instrument, Convertible, Threshold Consecutive Trading Days",
        "terseLabel": "Number of consecutive trading days"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleThresholdConsecutiveTradingDays1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "integerItemType"
    },
    "us-gaap_DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Minimum percentage of common stock price to conversion price of convertible debt instruments to determine eligibility of conversion.",
        "label": "Debt Instrument, Convertible, Threshold Percentage of Stock Price Trigger",
        "terseLabel": "Stock price trigger to classify convertible debt as current (as a percent)"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleThresholdPercentageOfStockPriceTrigger",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_DebtInstrumentConvertibleThresholdTradingDays": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Threshold number of specified trading days that common stock price to conversion price of convertible debt instruments must exceed threshold percentage within a specified consecutive trading period to trigger conversion feature.",
        "label": "Debt Instrument, Convertible, Threshold Trading Days",
        "terseLabel": "Number of trading days"
       }
      }
     },
     "localname": "DebtInstrumentConvertibleThresholdTradingDays",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "integerItemType"
    },
    "us-gaap_DebtInstrumentFaceAmount": {
     "auth_ref": [
      "r432",
      "r434"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Face (par) amount of debt instrument at time of issuance.",
        "label": "Debt Instrument, Face Amount",
        "terseLabel": "Principal amount outstanding"
       }
      }
     },
     "localname": "DebtInstrumentFaceAmount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtInstrumentInterestRateEffectivePercentage": {
     "auth_ref": [
      "r50",
      "r235",
      "r432"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Effective interest rate for the funds borrowed under the debt agreement considering interest compounding and original issue discount or premium.",
        "label": "Debt Instrument, Interest Rate, Effective Percentage",
        "terseLabel": "Effective rate (as a percent)"
       }
      }
     },
     "localname": "DebtInstrumentInterestRateEffectivePercentage",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_DebtInstrumentInterestRateStatedPercentage": {
     "auth_ref": [
      "r50"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contractual interest rate for funds borrowed, under the debt agreement.",
        "label": "Debt Instrument, Interest Rate, Stated Percentage",
        "terseLabel": "Interest on debt instrument (as a percent)"
       }
      }
     },
     "localname": "DebtInstrumentInterestRateStatedPercentage",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_DebtInstrumentLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Debt Instrument [Line Items]",
        "terseLabel": "Debt Instrument [Line Items]"
       }
      }
     },
     "localname": "DebtInstrumentLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtInstrumentNameDomain": {
     "auth_ref": [
      "r52"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The name for the particular debt instrument or borrowing that distinguishes it from other debt instruments or borrowings, including draws against credit facilities.",
        "label": "Debt Instrument, Name [Domain]",
        "terseLabel": "Debt Instrument, Name [Domain]"
       }
      }
     },
     "localname": "DebtInstrumentNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtInstrumentRedemptionPeriodAxis": {
     "auth_ref": [
      "r482"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information about timing of debt redemption features under terms of the debt agreement.",
        "label": "Debt Instrument, Redemption, Period [Axis]",
        "terseLabel": "Debt Instrument, Redemption, Period [Axis]"
       }
      }
     },
     "localname": "DebtInstrumentRedemptionPeriodAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtInstrumentRedemptionPeriodDomain": {
     "auth_ref": [
      "r482"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period as defined under terms of the debt agreement for debt redemption features.",
        "label": "Debt Instrument, Redemption, Period [Domain]",
        "terseLabel": "Debt Instrument, Redemption, Period [Domain]"
       }
      }
     },
     "localname": "DebtInstrumentRedemptionPeriodDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtInstrumentRedemptionPeriodOneMember": {
     "auth_ref": [
      "r482"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period one representing most current period of debt redemption features under terms of the debt agreement.",
        "label": "Debt Instrument, Redemption, Period One [Member]",
        "terseLabel": "Redemption Period One"
       }
      }
     },
     "localname": "DebtInstrumentRedemptionPeriodOneMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtInstrumentRedemptionPeriodTwoMember": {
     "auth_ref": [
      "r482"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period two representing second most current period of debt redemption features under terms of the debt agreement.",
        "label": "Debt Instrument, Redemption, Period Two [Member]",
        "terseLabel": "Redemption Period Two"
       }
      }
     },
     "localname": "DebtInstrumentRedemptionPeriodTwoMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtInstrumentTable": {
     "auth_ref": [
      "r52",
      "r129",
      "r240",
      "r242",
      "r243",
      "r244",
      "r431",
      "r432",
      "r434",
      "r483"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A table or schedule providing information pertaining to long-term debt instruments or arrangements, including identification, terms, features, collateral requirements and other information necessary to a fair presentation. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the company, if longer.",
        "label": "Schedule of Long-term Debt Instruments [Table]",
        "terseLabel": "Schedule of Long-term Debt Instruments [Table]"
       }
      }
     },
     "localname": "DebtInstrumentTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtInstrumentUnamortizedDiscount": {
     "auth_ref": [
      "r431",
      "r434"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, after accumulated amortization, of debt discount.",
        "label": "Debt Instrument, Unamortized Discount",
        "negatedTerseLabel": "Unamortized discount"
       }
      }
     },
     "localname": "DebtInstrumentUnamortizedDiscount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtInstrumentUnamortizedPremium": {
     "auth_ref": [
      "r431",
      "r434"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, after accumulated amortization, of debt premium.",
        "label": "Debt Instrument, Unamortized Premium",
        "terseLabel": "Debt issuance costs related to the liability component of convertible debt"
       }
      }
     },
     "localname": "DebtInstrumentUnamortizedPremium",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DebtMember": {
     "auth_ref": [
      "r319"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contractual obligation to pay money on demand or on fixed or determinable dates.",
        "label": "Debt [Member]",
        "terseLabel": "Debt"
       }
      }
     },
     "localname": "DebtMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DebtSecuritiesAvailableForSaleTable": {
     "auth_ref": [
      "r190"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of information about investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale [Table]",
        "terseLabel": "Debt Securities, Available-for-sale [Table]"
       }
      }
     },
     "localname": "DebtSecuritiesAvailableForSaleTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DebtSecuritiesAvailableForSaleTableTextBlock": {
     "auth_ref": [
      "r190"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).",
        "label": "Debt Securities, Available-for-sale [Table Text Block]",
        "terseLabel": "Schedule of Investment Categories"
       }
      }
     },
     "localname": "DebtSecuritiesAvailableForSaleTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_DeferredFederalIncomeTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r348",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred federal income tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Deferred Federal Income Tax Expense (Benefit)",
        "terseLabel": "Federal"
       }
      }
     },
     "localname": "DeferredFederalIncomeTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredFinanceCostsGross": {
     "auth_ref": [
      "r433"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before accumulated amortization, of debt issuance costs. Includes, but is not limited to, legal, accounting, underwriting, printing, and registration costs.",
        "label": "Debt Issuance Costs, Gross",
        "terseLabel": "Debt issuance costs"
       }
      }
     },
     "localname": "DeferredFinanceCostsGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredForeignIncomeTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r348",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred foreign income tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Deferred Foreign Income Tax Expense (Benefit)",
        "terseLabel": "Foreign"
       }
      }
     },
     "localname": "DeferredForeignIncomeTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredIncomeTaxAssetsNet": {
     "auth_ref": [
      "r341"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, with jurisdictional netting.",
        "label": "Deferred Income Tax Assets, Net",
        "terseLabel": "Deferred income taxes, net"
       }
      }
     },
     "localname": "DeferredIncomeTaxAssetsNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]",
        "terseLabel": "Deferred expense (benefit):"
       }
      }
     },
     "localname": "DeferredIncomeTaxExpenseBenefitContinuingOperationsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DeferredIncomeTaxLiabilities": {
     "auth_ref": [
      "r28",
      "r29",
      "r337",
      "r466",
      "r485"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_DeferredTaxAssetsLiabilitiesNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred tax liability attributable to taxable temporary differences.",
        "label": "Deferred Tax Liabilities, Gross",
        "negatedTotalLabel": "Net deferred tax liabilities"
       }
      }
     },
     "localname": "DeferredIncomeTaxLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r348",
      "r351"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred state and local tax expense (benefit) pertaining to income (loss) from continuing operations.",
        "label": "Deferred State and Local Income Tax Expense (Benefit)",
        "terseLabel": "State"
       }
      }
     },
     "localname": "DeferredStateAndLocalIncomeTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsCapitalLossCarryforwards": {
     "auth_ref": [
      "r318",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 6.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible capital loss carryforwards.",
        "label": "Deferred Tax Assets, Capital Loss Carryforwards",
        "terseLabel": "Capital Loss Carryforward"
       }
      }
     },
     "localname": "DeferredTaxAssetsCapitalLossCarryforwards",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsDeferredIncome": {
     "auth_ref": [
      "r318",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from deferred income.",
        "label": "Deferred Tax Assets, Deferred Income",
        "terseLabel": "Deferred revenue"
       }
      }
     },
     "localname": "DeferredTaxAssetsDeferredIncome",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsEquityMethodInvestments": {
     "auth_ref": [
      "r318",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 7.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from equity method investments.",
        "label": "Deferred Tax Assets, Equity Method Investments",
        "terseLabel": "Investment in Viking"
       }
      }
     },
     "localname": "DeferredTaxAssetsEquityMethodInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsGross": {
     "auth_ref": [
      "r338"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_DeferredTaxAssetsNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.",
        "label": "Deferred Tax Assets, Gross",
        "totalLabel": "Deferred tax assets"
       }
      }
     },
     "localname": "DeferredTaxAssetsGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsGrossAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Deferred Tax Assets, Gross [Abstract]",
        "terseLabel": "Deferred assets:"
       }
      }
     },
     "localname": "DeferredTaxAssetsGrossAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DeferredTaxAssetsLiabilitiesNet": {
     "auth_ref": [
      "r341"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, after allocation of valuation allowances and deferred tax liability, of deferred tax asset attributable to deductible differences and carryforwards, without jurisdictional netting.",
        "label": "Deferred Tax Assets, Net",
        "totalLabel": "Total"
       }
      }
     },
     "localname": "DeferredTaxAssetsLiabilitiesNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsNet": {
     "auth_ref": [
      "r339"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_DeferredTaxAssetsLiabilitiesNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.",
        "label": "Deferred Tax Assets, Net of Valuation Allowance",
        "totalLabel": "Net deferred tax assets"
       }
      }
     },
     "localname": "DeferredTaxAssetsNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsOperatingLossCarryforwards": {
     "auth_ref": [
      "r317",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible operating loss carryforwards.",
        "label": "Deferred Tax Assets, Operating Loss Carryforwards",
        "terseLabel": "Net operating loss carryforwards"
       }
      }
     },
     "localname": "DeferredTaxAssetsOperatingLossCarryforwards",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsOther": {
     "auth_ref": [
      "r318",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 8.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before allocation of valuation allowance, of deferred tax asset attributable to deductible temporary differences, classified as other.",
        "label": "Deferred Tax Assets, Other",
        "terseLabel": "Other"
       }
      }
     },
     "localname": "DeferredTaxAssetsOther",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsTaxCreditCarryforwards": {
     "auth_ref": [
      "r343",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, before allocation of a valuation allowances, of deferred tax assets attributable to deductible tax credit carryforwards including, but not limited to, research, foreign, general business, alternative minimum tax, and other deductible tax credit carryforwards.",
        "label": "Deferred Tax Assets, Tax Credit Carryforwards",
        "terseLabel": "Research credit carryforwards"
       }
      }
     },
     "localname": "DeferredTaxAssetsTaxCreditCarryforwards",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities": {
     "auth_ref": [
      "r317",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_DeferredTaxAssetsGross",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from accrued liabilities.",
        "label": "Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Accrued Liabilities",
        "terseLabel": "Accrued expenses"
       }
      }
     },
     "localname": "DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxAssetsValuationAllowance": {
     "auth_ref": [
      "r340"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_DeferredTaxAssetsNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized.",
        "label": "Deferred Tax Assets, Valuation Allowance",
        "negatedTerseLabel": "Valuation allowance for deferred tax assets"
       }
      }
     },
     "localname": "DeferredTaxAssetsValuationAllowance",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxLiabilitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Deferred Tax Liabilities, Gross [Abstract]",
        "terseLabel": "Deferred tax liabilities:"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DeferredTaxLiabilitiesFinancingArrangements": {
     "auth_ref": [
      "r318",
      "r345",
      "r346"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_DeferredIncomeTaxLiabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred tax liability attributable to taxable temporary differences from financing arrangements.",
        "label": "Deferred Tax Liabilities, Financing Arrangements",
        "negatedTerseLabel": "Convertible debt"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesFinancingArrangements",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DeferredTaxLiabilitiesInvestments": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_DeferredIncomeTaxLiabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of deferred tax liability attributable to taxable temporary differences from investments (excludes investments in subsidiaries and equity method investments).",
        "label": "Deferred Tax Liabilities, Investments",
        "negatedLabel": "Investment in Viking"
       }
      }
     },
     "localname": "DeferredTaxLiabilitiesInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesDeferredTaxesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DemandDepositsMember": {
     "auth_ref": [
      "r508"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accounts that may or may not bear interest and that depositor is entitled to withdraw at anytime without prior notice. Checking and negotiable order of withdrawal (NOW) accounts are the most common forms of demand deposits.",
        "label": "Demand Deposits [Member]",
        "terseLabel": "Bank deposits"
       }
      }
     },
     "localname": "DemandDepositsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_Depreciation": {
     "auth_ref": [
      "r115",
      "r217"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.",
        "label": "Depreciation",
        "verboseLabel": "Depreciation expense"
       }
      }
     },
     "localname": "Depreciation",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DepreciationDepletionAndAmortization": {
     "auth_ref": [
      "r115",
      "r172"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 4.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate expense recognized in the current period that allocates the cost of tangible assets, intangible assets, or depleting assets to periods that benefit from use of the assets.",
        "label": "Depreciation, Depletion and Amortization",
        "verboseLabel": "Depreciation and amortization"
       }
      }
     },
     "localname": "DepreciationDepletionAndAmortization",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DerivativeAssetsCurrent": {
     "auth_ref": [
      "r61"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 7.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value, after the effects of master netting arrangements, of a financial asset or other contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.",
        "label": "Derivative Asset, Current",
        "terseLabel": "Derivative asset"
       }
      }
     },
     "localname": "DerivativeAssetsCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DerivativeContractTypeDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Financial instrument or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset.",
        "label": "Derivative Contract [Domain]",
        "terseLabel": "Derivative Contract [Domain]"
       }
      }
     },
     "localname": "DerivativeContractTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DerivativeGainLossOnDerivativeNet": {
     "auth_ref": [
      "r400"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in the fair value of derivatives recognized in the income statement.",
        "label": "Derivative, Gain (Loss) on Derivative, Net",
        "negatedLabel": "Net change in fair value of derivatives",
        "terseLabel": "Gain (loss) on derivative liabilities"
       }
      }
     },
     "localname": "DerivativeGainLossOnDerivativeNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DerivativeInstrumentRiskAxis": {
     "auth_ref": [
      "r399",
      "r402",
      "r404",
      "r405"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of derivative contract.",
        "label": "Derivative Instrument [Axis]",
        "terseLabel": "Derivative, by Nature [Axis]"
       }
      }
     },
     "localname": "DerivativeInstrumentRiskAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Derivative Instruments and Hedging Activities Disclosures [Line Items]",
        "terseLabel": "Derivative Instruments and Hedging Activities Disclosures [Line Items]"
       }
      }
     },
     "localname": "DerivativeInstrumentsAndHedgingActivitiesDisclosuresLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of information about derivatives and hedging activities.",
        "label": "Derivative Instruments and Hedging Activities Disclosures [Table]",
        "terseLabel": "Derivative Instruments and Hedging Activities Disclosures [Table]"
       }
      }
     },
     "localname": "DerivativeInstrumentsAndHedgingActivitiesDisclosuresTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DerivativeLiabilitiesCurrent": {
     "auth_ref": [
      "r61"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 6.0,
       "parentTag": "us-gaap_LiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value, after the effects of master netting arrangements, of a financial liability or contract with one or more underlyings, notional amount or payment provision or both, and the contract can be net settled by means outside the contract or delivery of an asset, expected to be settled within one year or normal operating cycle, if longer. Includes assets not subject to a master netting arrangement and not elected to be offset.",
        "label": "Derivative Liability, Current",
        "terseLabel": "Derivative liability"
       }
      }
     },
     "localname": "DerivativeLiabilitiesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DerivativeLiabilityMeasurementInput": {
     "auth_ref": [
      "r413"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of input used to measure derivative liability.",
        "label": "Derivative Liability, Measurement Input",
        "terseLabel": "Derivative liability, measurement input"
       }
      }
     },
     "localname": "DerivativeLiabilityMeasurementInput",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "decimalItemType"
    },
    "us-gaap_DevelopedTechnologyRightsMember": {
     "auth_ref": [
      "r366"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Rights to developed technology, which can include the right to develop, use, market, sell, or offer for sale products, compounds, or intellectual property.",
        "label": "Developed Technology Rights [Member]",
        "terseLabel": "Core Technology"
       }
      }
     },
     "localname": "DevelopedTechnologyRightsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member": {
     "auth_ref": [
      "r260"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Effect in current period from application of guidance for revenue from contract with customer compared with guidance for revenue recognition applicable prior to change when using transition method for cumulative effect in period including initial date of application.",
        "label": "Difference between Revenue Guidance in Effect before and after Topic 606 [Member]",
        "terseLabel": "Difference between Revenue Guidance in Effect before and after Topic 606"
       }
      }
     },
     "localname": "DifferenceBetweenRevenueGuidanceInEffectBeforeAndAfterTopic606Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DirectorMember": {
     "auth_ref": [
      "r442"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Person serving on the board of directors (who collectively have responsibility for governing the entity).",
        "label": "Director [Member]",
        "terseLabel": "Director"
       }
      }
     },
     "localname": "DirectorMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_DisaggregationOfRevenueLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Disaggregation of Revenue [Line Items]",
        "terseLabel": "Disaggregation of Revenue [Line Items]"
       }
      }
     },
     "localname": "DisaggregationOfRevenueLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DisaggregationOfRevenueTable": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of information about disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor.",
        "label": "Disaggregation of Revenue [Table]",
        "terseLabel": "Disaggregation of Revenue [Table]"
       }
      }
     },
     "localname": "DisaggregationOfRevenueTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DisaggregationOfRevenueTableTextBlock": {
     "auth_ref": [
      "r253"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor.",
        "label": "Disaggregation of Revenue [Table Text Block]",
        "terseLabel": "Schedule of Disaggregation of Revenue"
       }
      }
     },
     "localname": "DisaggregationOfRevenueTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Disclosure of Compensation Related Costs, Share-based Payments [Abstract]"
       }
      }
     },
     "localname": "DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax": {
     "auth_ref": [
      "r1",
      "r3",
      "r4"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before tax of gain (loss) not previously recognized resulting from the disposal of a discontinued operation.",
        "label": "Discontinued Operation, Gain (Loss) from Disposal of Discontinued Operation, before Income Tax",
        "terseLabel": "Gain on sale of Oncology Product Line before income taxes"
       }
      }
     },
     "localname": "DiscontinuedOperationGainLossFromDisposalOfDiscontinuedOperationBeforeIncomeTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax": {
     "auth_ref": [
      "r1",
      "r3",
      "r4",
      "r6"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_NetIncomeLoss",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of gain (loss) not previously recognized resulting from the disposal of a discontinued operation.",
        "label": "Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax",
        "totalLabel": "Income from discontinued operations"
       }
      }
     },
     "localname": "DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Discontinued Operation, Gain (Loss) on Disposal of Discontinued Operation, Net of Tax [Abstract]",
        "verboseLabel": "Discontinued operations:"
       }
      }
     },
     "localname": "DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTaxAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax": {
     "auth_ref": [
      "r1",
      "r2",
      "r6"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 1.0,
       "parentTag": "us-gaap_ProfitLoss",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of income (loss) from operations classified as a discontinued operation. Excludes gain (loss) on disposal and provision for gain (loss) until disposal.",
        "label": "Discontinued Operation, Income (Loss) from Discontinued Operation During Phase-out Period, Net of Tax",
        "terseLabel": "Less: gain from discontinued operations"
       }
      }
     },
     "localname": "DiscontinuedOperationIncomeLossFromDiscontinuedOperationDuringPhaseOutPeriodNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation": {
     "auth_ref": [
      "r3",
      "r4",
      "r6",
      "r326",
      "r353"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_DiscontinuedOperationGainLossOnDisposalOfDiscontinuedOperationNetOfTax",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of tax expense (benefit) on gain (loss) not previously recognized resulting from the disposal of a discontinued operation.",
        "label": "Discontinued Operation, Tax Effect of Gain (Loss) from Disposal of Discontinued Operation",
        "negatedTerseLabel": "Income tax expense on discontinued operations",
        "terseLabel": "Provision for taxes on gain from discontinued operations"
       }
      }
     },
     "localname": "DiscontinuedOperationTaxEffectOfIncomeLossFromDisposalOfDiscontinuedOperation",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_DiscontinuedOperationsPolicyTextBlock": {
     "auth_ref": [
      "r5",
      "r7",
      "r124",
      "r150"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for discontinued operations. Includes, but is not limited to, method of interest allocation to a discontinued operation.",
        "label": "Discontinued Operations, Policy [Policy Text Block]",
        "terseLabel": "Discontinued Operations"
       }
      }
     },
     "localname": "DiscontinuedOperationsPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_EarningsPerShareBasic": {
     "auth_ref": [
      "r85",
      "r138",
      "r142",
      "r146",
      "r147",
      "r148",
      "r152",
      "r480",
      "r501"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.",
        "label": "Earnings Per Share, Basic",
        "terseLabel": "Net income (loss) - Basic (USD per share)",
        "totalLabel": "Net income (loss) - Basic (USD per share)"
       }
      }
     },
     "localname": "EarningsPerShareBasic",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_EarningsPerShareBasicAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Earnings Per Share, Basic [Abstract]",
        "terseLabel": "Basic per share amounts:",
        "verboseLabel": "Basic per share amounts:"
       }
      }
     },
     "localname": "EarningsPerShareBasicAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_EarningsPerShareBasicAndDilutedAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Earnings Per Share, Basic and Diluted [Abstract]",
        "verboseLabel": "Dilutive potential common shares:"
       }
      }
     },
     "localname": "EarningsPerShareBasicAndDilutedAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_EarningsPerShareDiluted": {
     "auth_ref": [
      "r85",
      "r138",
      "r142",
      "r146",
      "r147",
      "r148",
      "r152",
      "r480",
      "r501"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.",
        "label": "Earnings Per Share, Diluted",
        "terseLabel": "Net income (loss) - Diluted (USD per share)",
        "totalLabel": "Net (loss) income - Diluted (USD per share)",
        "verboseLabel": "Earnings per share - diluted (USD per share)"
       }
      }
     },
     "localname": "EarningsPerShareDiluted",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_EarningsPerShareDilutedAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Earnings Per Share, Diluted [Abstract]",
        "terseLabel": "Diluted per share amounts:",
        "verboseLabel": "Diluted per share amounts:"
       }
      }
     },
     "localname": "EarningsPerShareDilutedAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_EarningsPerSharePolicyTextBlock": {
     "auth_ref": [
      "r124",
      "r149",
      "r150",
      "r151"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for computing basic and diluted earnings or loss per share for each class of common stock and participating security. Addresses all significant policy factors, including any antidilutive items that have been excluded from the computation and takes into account stock dividends, splits and reverse splits that occur after the balance sheet date of the latest reporting period but before the issuance of the financial statements.",
        "label": "Earnings Per Share, Policy [Policy Text Block]",
        "verboseLabel": "Income (Loss) Per Share"
       }
      }
     },
     "localname": "EarningsPerSharePolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents": {
     "auth_ref": [
      "r427"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) from effect of exchange rate changes on cash and cash equivalents, and cash and cash equivalents restricted to withdrawal or usage; held in foreign currencies. Excludes amounts for disposal group and discontinued operations. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. Cash equivalents include, but are not limited to, short-term, highly liquid investments that are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates.",
        "label": "Effect of Exchange Rate on Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents",
        "terseLabel": "Effect of exchange rate changes on cash"
       }
      }
     },
     "localname": "EffectOfExchangeRateOnCashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability": {
     "auth_ref": [
      "r401"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value as of the balance sheet date of the embedded derivative or group of embedded derivatives classified as a liability.",
        "label": "Embedded Derivative, Fair Value of Embedded Derivative Liability",
        "terseLabel": "Fair value of the conversion option derivative liability"
       }
      }
     },
     "localname": "EmbeddedDerivativeFairValueOfEmbeddedDerivativeLiability",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EmployeeRelatedLiabilitiesCurrent": {
     "auth_ref": [
      "r48"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Total of the carrying values as of the balance sheet date of obligations incurred through that date and payable for obligations related to services received from employees, such as accrued salaries and bonuses, payroll taxes and fringe benefits. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer).",
        "label": "Employee-related Liabilities, Current",
        "terseLabel": "Compensation"
       }
      }
     },
     "localname": "EmployeeRelatedLiabilitiesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1": {
     "auth_ref": [
      "r300"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition",
        "verboseLabel": "Weighted-average period in which cost is expected to be recognized"
       }
      }
     },
     "localname": "EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions": {
     "auth_ref": [
      "r300"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Unrecognized cost of unvested share-based awards, other than options, awarded to employees as compensation.",
        "label": "Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options",
        "verboseLabel": "Unrecognized compensation cost, restricted stock"
       }
      }
     },
     "localname": "EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedShareBasedAwardsOtherThanOptions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions": {
     "auth_ref": [
      "r300"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Unrecognized cost of unvested options awarded to employees as compensation.",
        "label": "Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options",
        "verboseLabel": "Unrecognized compensation cost"
       }
      }
     },
     "localname": "EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EmployeeStockOptionMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "An arrangement whereby an employee is entitled to receive in the future, subject to vesting and other restrictions, a number of shares in the entity at a specified price, as defined in the agreement. Although there are variations, normally, after vesting, when an option is exercised, the employee-holder pays the strike value in cash to the issuing employer-entity and receives equity shares. The equity shares can be sold into the market for cash at the current market price without restriction. Options may be used to attract, retain and incentivize employees, in addition to their regular salary and other benefits.",
        "label": "Employee Stock Option [Member]",
        "terseLabel": "Stock Options"
       }
      }
     },
     "localname": "EmployeeStockOptionMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_EntityWideRevenueMajorCustomerLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Revenue, Major Customer [Line Items]",
        "terseLabel": "Revenue, Major Customer"
       }
      }
     },
     "localname": "EntityWideRevenueMajorCustomerLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_EquityAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Equity [Abstract]"
       }
      }
     },
     "localname": "EquityAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_EquityComponentDomain": {
     "auth_ref": [
      "r239"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Components of equity are the parts of the total Equity balance including that which is allocated to common, preferred, treasury stock, retained earnings, etc.",
        "label": "Equity Component [Domain]",
        "terseLabel": "Total stockholders\u2019 equity",
        "verboseLabel": "Equity Component [Domain]"
       }
      }
     },
     "localname": "EquityComponentDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_EquityMethodInvesteeMember": {
     "auth_ref": [
      "r192",
      "r453",
      "r455",
      "r457",
      "r459",
      "r461",
      "r463"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "An entity that issued voting stock held by an investor and that is accounted for under the equity method of accounting by the investor.",
        "label": "Equity Method Investee [Member]",
        "terseLabel": "Equity Method Investee"
       }
      }
     },
     "localname": "EquityMethodInvesteeMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_EquityMethodInvestmentOwnershipPercentage": {
     "auth_ref": [
      "r194"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting.",
        "label": "Equity Method Investment, Ownership Percentage",
        "terseLabel": "Aggregate ownership (as a percent)"
       }
      }
     },
     "localname": "EquityMethodInvestmentOwnershipPercentage",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_EquityMethodInvestments": {
     "auth_ref": [
      "r40",
      "r176",
      "r193"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 8.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This item represents the carrying amount on the entity's balance sheet of its investment in common stock of an equity method investee. This is not an indicator of the fair value of the investment, rather it is the initial cost adjusted for the entity's share of earnings and losses of the investee, adjusted for any distributions (dividends) and other than temporary impairment (OTTI) losses recognized.",
        "label": "Equity Method Investments",
        "terseLabel": "Investment in Viking"
       }
      }
     },
     "localname": "EquityMethodInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EquitySecuritiesFvNi": {
     "auth_ref": [
      "r420"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).",
        "label": "Equity Securities, FV-NI",
        "terseLabel": "Investment in Viking"
       }
      }
     },
     "localname": "EquitySecuritiesFvNi",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EquitySecuritiesFvNiGainLoss": {
     "auth_ref": [
      "r191"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_NonoperatingIncomeExpense",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of unrealized and realized gain (loss) on investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).",
        "label": "Equity Securities, FV-NI, Gain (Loss)",
        "terseLabel": "Gain (loss) from Viking"
       }
      }
     },
     "localname": "EquitySecuritiesFvNiGainLoss",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_EquitySecuritiesFvNiMeasurementInput": {
     "auth_ref": [
      "r413"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of input used to measure investment in equity security measured at fair value with change in fair value recognized in net income (FV-NI).",
        "label": "Equity Securities, FV-NI, Measurement Input",
        "terseLabel": "Measurement input"
       }
      }
     },
     "localname": "EquitySecuritiesFvNiMeasurementInput",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "decimalItemType"
    },
    "us-gaap_EquitySecuritiesMember": {
     "auth_ref": [
      "r20",
      "r24",
      "r190",
      "r473",
      "r487",
      "r513"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Ownership interest or right to acquire or dispose of ownership interest in corporations and other legal entities for which ownership interest is represented by shares of common or preferred stock, convertible securities, stock rights, or stock warrants.",
        "label": "Equity Securities [Member]",
        "terseLabel": "Corporate equity securities"
       }
      }
     },
     "localname": "EquitySecuritiesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]",
        "terseLabel": "Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]"
       }
      }
     },
     "localname": "FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable": {
     "auth_ref": [
      "r408",
      "r409",
      "r410",
      "r411",
      "r418",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of information about financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.",
        "label": "Fair Value Measurements, Recurring and Nonrecurring [Table]",
        "terseLabel": "Fair Value Measurements, Recurring and Nonrecurring [Table]"
       }
      }
     },
     "localname": "FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock": {
     "auth_ref": [
      "r408",
      "r409",
      "r410",
      "r411",
      "r418",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of financial instruments measured at fair value, including those classified in shareholders' equity measured on a recurring or nonrecurring basis. Disclosures include, but are not limited to, fair value measurements recorded and the reasons for the measurements, level within the fair value hierarchy in which the fair value measurements are categorized and transfers between levels 1 and 2. Nonrecurring fair value measurements are those that are required or permitted in the statement of financial position in particular circumstances.",
        "label": "Fair Value Measurements, Recurring and Nonrecurring [Table Text Block]",
        "terseLabel": "Schedule of Assets and Liabilities Measured on Recurring Basis"
       }
      }
     },
     "localname": "FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain": {
     "auth_ref": [
      "r414",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Class of asset.",
        "label": "Asset Class [Domain]",
        "terseLabel": "Fair Value by Asset Class [Domain]"
       }
      }
     },
     "localname": "FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationByAssetClassDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]",
        "terseLabel": "Assets:"
       }
      }
     },
     "localname": "FairValueAssetsMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueByAssetClassAxis": {
     "auth_ref": [
      "r409",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by class of asset.",
        "label": "Asset Class [Axis]",
        "terseLabel": "Asset Class [Axis]"
       }
      }
     },
     "localname": "FairValueByAssetClassAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueByFairValueHierarchyLevelAxis": {
     "auth_ref": [
      "r263",
      "r264",
      "r266",
      "r410",
      "r446"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by level within fair value hierarchy and fair value measured at net asset value per share as practical expedient.",
        "label": "Fair Value Hierarchy and NAV [Axis]",
        "terseLabel": "Fair Value Hierarchy and NAV [Axis]"
       }
      }
     },
     "localname": "FairValueByFairValueHierarchyLevelAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueByLiabilityClassAxis": {
     "auth_ref": [
      "r417",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by class of liability.",
        "label": "Liability Class [Axis]",
        "terseLabel": "Liability Class [Axis]"
       }
      }
     },
     "localname": "FairValueByLiabilityClassAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueByMeasurementFrequencyAxis": {
     "auth_ref": [
      "r408"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by measurement frequency.",
        "label": "Measurement Frequency [Axis]",
        "terseLabel": "Measurement Frequency [Axis]"
       }
      }
     },
     "localname": "FairValueByMeasurementFrequencyAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueDisclosuresAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Fair Value Disclosures [Abstract]"
       }
      }
     },
     "localname": "FairValueDisclosuresAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueInputsLevel1Member": {
     "auth_ref": [
      "r263",
      "r264",
      "r266",
      "r410",
      "r447"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Quoted prices in active markets for identical assets or liabilities that the reporting entity can access at the measurement date.",
        "label": "Fair Value, Inputs, Level 1 [Member]",
        "verboseLabel": "Quoted Prices in Active Markets for Identical Assets (Level 1)"
       }
      }
     },
     "localname": "FairValueInputsLevel1Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueInputsLevel2Member": {
     "auth_ref": [
      "r263",
      "r264",
      "r266",
      "r410",
      "r448"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Inputs other than quoted prices included within level 1 that are observable for an asset or liability, either directly or indirectly, including, but not limited to, quoted prices for similar assets or liabilities in active markets, or quoted prices for identical or similar assets or liabilities in inactive markets.",
        "label": "Fair Value, Inputs, Level 2 [Member]",
        "verboseLabel": "Significant Other Observable Inputs (Level 2)"
       }
      }
     },
     "localname": "FairValueInputsLevel2Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueInputsLevel3Member": {
     "auth_ref": [
      "r263",
      "r264",
      "r266",
      "r410",
      "r449"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.",
        "label": "Fair Value, Inputs, Level 3 [Member]",
        "verboseLabel": "Significant Unobservable Inputs (Level 3)"
       }
      }
     },
     "localname": "FairValueInputsLevel3Member",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain": {
     "auth_ref": [
      "r414",
      "r419"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Represents classes of liabilities measured and disclosed at fair value.",
        "label": "Fair Value by Liability Class [Domain]",
        "terseLabel": "Fair Value by Liability Class [Domain]"
       }
      }
     },
     "localname": "FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]",
        "terseLabel": "Liabilities"
       }
      }
     },
     "localname": "FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FairValueMeasurementFrequencyDomain": {
     "auth_ref": [
      "r408",
      "r417"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Provides the general categories used to describe the frequency with which financial assets and liabilities (as defined) are measured at fair value (on a recurring or nonrecurring basis).",
        "label": "Fair Value, Measurement Frequency [Domain]",
        "terseLabel": "Fair Value, Measurement Frequency [Domain]"
       }
      }
     },
     "localname": "FairValueMeasurementFrequencyDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements": {
     "auth_ref": [
      "r415"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of settlement of financial instrument classified as an asset measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Settlements",
        "terseLabel": "Notes receivable fair market value adjustment"
       }
      }
     },
     "localname": "FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetSettlements",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3": {
     "auth_ref": [
      "r416"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of transfer of financial instrument classified as an asset into level 3 of the fair value hierarchy.",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Transfers Into Level 3",
        "negatedTerseLabel": "Cash payment received as partial repayment of note receivable"
       }
      }
     },
     "localname": "FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetTransfersIntoLevel3",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue": {
     "auth_ref": [
      "r414"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value of financial instrument classified as an asset measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset Value",
        "periodEndLabel": "Fair value of level 3 financial instruments at end of period",
        "periodStartLabel": "Fair value of level 3 financial instruments at beginning of period"
       }
      }
     },
     "localname": "FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisAssetValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue": {
     "auth_ref": [
      "r414"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value of financial instrument classified as a liability measured using unobservable inputs that reflect the entity's own assumption about the assumptions market participants would use in pricing.",
        "label": "Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value",
        "periodEndLabel": "Fair value of level 3 financial instruments at end of period",
        "periodStartLabel": "Fair value of level 3 financial instruments at beginning of period"
       }
      }
     },
     "localname": "FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FairValueMeasurementsFairValueHierarchyDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Categories used to prioritize the inputs to valuation techniques to measure fair value.",
        "label": "Fair Value Hierarchy and NAV [Domain]",
        "terseLabel": "Fair Value, Measurements, Fair Value Hierarchy [Domain]"
       }
      }
     },
     "localname": "FairValueMeasurementsFairValueHierarchyDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueMeasurementsRecurringMember": {
     "auth_ref": [
      "r408",
      "r417"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This item represents a description of the frequency with which certain items are measured at fair value. Items measured at fair value on a recurring basis generally include those items for which measurement inputs are readily available and which are measured at fair value at successive reporting periods.",
        "label": "Fair Value, Measurements, Recurring [Member]",
        "verboseLabel": "Recurring"
       }
      }
     },
     "localname": "FairValueMeasurementsRecurringMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FairValueOptionChangesInFairValueGainLoss1": {
     "auth_ref": [
      "r424"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "For each line item in the statement of financial position, the amounts of gains and losses from fair value changes included in earnings.",
        "label": "Fair Value, Option, Changes in Fair Value, Gain (Loss)",
        "terseLabel": "Gain on changes in fair value"
       }
      }
     },
     "localname": "FairValueOptionChangesInFairValueGainLoss1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FinancialInstrumentAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of financial instrument.",
        "label": "Financial Instrument [Axis]",
        "terseLabel": "Financial Instrument [Axis]"
       }
      }
     },
     "localname": "FinancialInstrumentAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FinancialInstrumentsDisclosureTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for financial instruments. This disclosure includes, but is not limited to, fair value measurements of short and long term marketable securities, international currencies forward contracts, and auction rate securities. Financial instruments may include hedging and non-hedging currency exchange instruments, derivatives, securitizations and securities available for sale at fair value. Also included are investment results, realized and unrealized gains and losses as well as impairments and risk management disclosures.",
        "label": "Financial Instruments Disclosure [Text Block]",
        "terseLabel": "Fair Value Measurement"
       }
      }
     },
     "localname": "FinancialInstrumentsDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurement"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetUsefulLife": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Useful life of finite-lived intangible assets, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Finite-Lived Intangible Asset, Useful Life",
        "verboseLabel": "Finite-lived intangible asset, useful life"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetUsefulLife",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization": {
     "auth_ref": [
      "r211"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_IntangibleAssetsNetIncludingGoodwill",
       "weight": -1.0
      },
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_FiniteLivedIntangibleAssetsNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Accumulated amount of amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.",
        "label": "Finite-Lived Intangible Assets, Accumulated Amortization",
        "negatedLabel": "Less: Accumulated amortization",
        "negatedTerseLabel": "Less: accumulated amortization"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAccumulatedAmortization",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths": {
     "auth_ref": [
      "r213"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Finite-Lived Intangible Assets, Amortization Expense, Next Twelve Months",
        "verboseLabel": "Amortization expense, 2019"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive": {
     "auth_ref": [
      "r213"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the fifth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Finite-Lived Intangible Assets, Amortization Expense, Year Five",
        "terseLabel": "Amortization expense, 2023"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAmortizationExpenseYearFive",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour": {
     "auth_ref": [
      "r213"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the fourth fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Finite-Lived Intangible Assets, Amortization Expense, Year Four",
        "terseLabel": "Amortization expense, 2022"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAmortizationExpenseYearFour",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree": {
     "auth_ref": [
      "r213"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the third fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Finite-Lived Intangible Assets, Amortization Expense, Year Three",
        "terseLabel": "Amortization expense, 2021"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAmortizationExpenseYearThree",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo": {
     "auth_ref": [
      "r213"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of amortization expense for assets, excluding financial assets and goodwill, lacking physical substance with a finite life expected to be recognized during the second fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Finite-Lived Intangible Assets, Amortization Expense, Year Two",
        "terseLabel": "Amortization expense, 2020"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsByMajorClassAxis": {
     "auth_ref": [
      "r206",
      "r208",
      "r211",
      "r215",
      "r451"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by major type or class of finite-lived intangible assets.",
        "label": "Finite-Lived Intangible Assets by Major Class [Axis]",
        "terseLabel": "Finite-Lived Intangible Assets by Major Class [Axis]"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsByMajorClassAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsGross": {
     "auth_ref": [
      "r211",
      "r451"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_IntangibleAssetsNetIncludingGoodwill",
       "weight": 1.0
      },
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_FiniteLivedIntangibleAssetsNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.",
        "label": "Finite-Lived Intangible Assets, Gross",
        "verboseLabel": "Definite lived intangible assets"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Finite-Lived Intangible Assets [Line Items]",
        "terseLabel": "Finite-Lived Intangible Assets [Line Items]"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsMajorClassNameDomain": {
     "auth_ref": [
      "r206",
      "r210"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The major class of finite-lived intangible asset (for example, patents, trademarks, copyrights, etc.) A major class is composed of intangible assets that can be grouped together because they are similar, either by their nature or by their use in the operations of a company.",
        "label": "Finite-Lived Intangible Assets, Major Class Name [Domain]",
        "terseLabel": "Finite-Lived Intangible Assets, Major Class Name [Domain]"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsMajorClassNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_FiniteLivedIntangibleAssetsNet": {
     "auth_ref": [
      "r211"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after amortization of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.",
        "label": "Finite-Lived Intangible Assets, Net",
        "totalLabel": "Total commercial license rights, net"
       }
      }
     },
     "localname": "FiniteLivedIntangibleAssetsNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock": {
     "auth_ref": [
      "r124",
      "r426",
      "r429"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for (1) transactions denominated in a currency other than the reporting enterprise's functional currency, (2) translating foreign currency financial statements that are incorporated into the financial statements of the reporting enterprise by consolidation, combination, or the equity method of accounting, and (3) remeasurement of the financial statements of a foreign reporting enterprise in a hyperinflationary economy.",
        "label": "Foreign Currency Transactions and Translations Policy [Policy Text Block]",
        "terseLabel": "Foreign Currency Translation"
       }
      }
     },
     "localname": "ForeignCurrencyTransactionsAndTranslationsPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_GainLossOnSaleOfBusiness": {
     "auth_ref": [
      "r115",
      "r380"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of gain (loss) from sale and disposal of integrated set of activities and assets capable of being conducted and managed for purpose of providing return in form of dividend, lower cost, or other economic benefit to investor, owner, member and participant.",
        "label": "Gain (Loss) on Disposition of Business",
        "terseLabel": "Gain on disposition of product line"
       }
      }
     },
     "localname": "GainLossOnSaleOfBusiness",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_GainsLossesOnExtinguishmentOfDebt": {
     "auth_ref": [
      "r115",
      "r236",
      "r237"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Difference between the fair value of payments made and the carrying amount of debt which is extinguished prior to maturity.",
        "label": "Gain (Loss) on Extinguishment of Debt",
        "terseLabel": "Gain (loss) on extinguishment of debt"
       }
      }
     },
     "localname": "GainsLossesOnExtinguishmentOfDebt",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_GeneralAndAdministrativeExpense": {
     "auth_ref": [
      "r90"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_OperatingCostsAndExpenses",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.",
        "label": "General and Administrative Expense",
        "verboseLabel": "General and administrative"
       }
      }
     },
     "localname": "GeneralAndAdministrativeExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_GeneralAndAdministrativeExpenseMember": {
     "auth_ref": [
      "r86"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Primary financial statement caption encompassing general and administrative expense.",
        "label": "General and Administrative Expense [Member]",
        "terseLabel": "General and administrative expenses"
       }
      }
     },
     "localname": "GeneralAndAdministrativeExpenseMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_Goodwill": {
     "auth_ref": [
      "r201",
      "r202"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 6.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": 1.0
      },
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 5.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after accumulated impairment loss of an asset representing future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized.",
        "label": "Goodwill",
        "terseLabel": "Goodwill",
        "verboseLabel": "Goodwill"
       }
      }
     },
     "localname": "Goodwill",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_GoodwillAndIntangibleAssetsGoodwillPolicy": {
     "auth_ref": [
      "r124",
      "r203"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for goodwill. This accounting policy also may address how an entity assesses and measures impairment of goodwill, how reporting units are determined, how goodwill is allocated to such units, and how the fair values of the reporting units are determined.",
        "label": "Goodwill and Intangible Assets, Goodwill, Policy [Policy Text Block]",
        "terseLabel": "Goodwill, Intangible Assets and Other Long-Lived Assets"
       }
      }
     },
     "localname": "GoodwillAndIntangibleAssetsGoodwillPolicy",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ImpairmentOfIntangibleAssetsFinitelived": {
     "auth_ref": [
      "r115",
      "r216"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of a finite-lived intangible asset to fair value.",
        "label": "Impairment of Intangible Assets, Finite-lived",
        "terseLabel": "Impairment of intangible assets with finite lives"
       }
      }
     },
     "localname": "ImpairmentOfIntangibleAssetsFinitelived",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ImpairmentOfInvestments": {
     "auth_ref": [
      "r184"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount by which the fair value of an investment is less than the amortized cost basis or carrying amount of that investment at the balance sheet date and the decline in fair value is deemed to be other than temporary, before considering whether or not such amount is recognized in earnings or other comprehensive income.",
        "label": "Other than Temporary Impairment Losses, Investments",
        "terseLabel": "Other than temporary impairment of investment in Viking"
       }
      }
     },
     "localname": "ImpairmentOfInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments": {
     "auth_ref": [
      "r130"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of income (loss) from continuing operations before deduction of income tax expense (benefit) and income (loss) attributable to noncontrolling interest, and addition of income (loss) from equity method investments.",
        "label": "Income (Loss) from Continuing Operations before Equity Method Investments, Income Taxes, Noncontrolling Interest",
        "totalLabel": "Income before income tax expense"
       }
      }
     },
     "localname": "IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest": {
     "auth_ref": [
      "r375"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 2.0,
       "parentTag": "us-gaap_ProfitLoss",
       "weight": 1.0
      },
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_NetIncomeLoss",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of income (loss) from continuing operations including portion attributable to the noncontrolling interest.",
        "label": "Income (Loss) from Continuing Operations, Net of Tax, Including Portion Attributable to Noncontrolling Interest",
        "terseLabel": "Income (loss) from continuing operations",
        "totalLabel": "Income (loss) from operations"
       }
      }
     },
     "localname": "IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeLossFromContinuingOperationsPerBasicShare": {
     "auth_ref": [
      "r80",
      "r85",
      "r142",
      "r146",
      "r147",
      "r476",
      "r478",
      "r480",
      "r498"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_EarningsPerShareBasic",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of net income (loss) from continuing operations per each share of common stock or unit outstanding during the reporting period.",
        "label": "Income (Loss) from Continuing Operations, Per Basic Share",
        "verboseLabel": "Income (loss) from continuing operations (USD per share)"
       }
      }
     },
     "localname": "IncomeLossFromContinuingOperationsPerBasicShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_IncomeLossFromContinuingOperationsPerDilutedShare": {
     "auth_ref": [
      "r80",
      "r85",
      "r142",
      "r146",
      "r147",
      "r148",
      "r480",
      "r498",
      "r501"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_EarningsPerShareDiluted",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of net income (loss) derived from continuing operations during the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.",
        "label": "Income (Loss) from Continuing Operations, Per Diluted Share",
        "verboseLabel": "Income (loss) from continuing operations (USD per share)"
       }
      }
     },
     "localname": "IncomeLossFromContinuingOperationsPerDilutedShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare": {
     "auth_ref": [
      "r83",
      "r85",
      "r144",
      "r146",
      "r147",
      "r480",
      "r499",
      "r501"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_EarningsPerShareBasic",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Per basic share amount, after tax, of income (loss) from the day-to-day business activities of the discontinued operation and gain (loss) from the disposal of the discontinued operation.",
        "label": "Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share",
        "terseLabel": "Income from discontinued operations (USD per share)"
       }
      }
     },
     "localname": "IncomeLossFromDiscontinuedOperationsNetOfTaxPerBasicShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare": {
     "auth_ref": [
      "r144",
      "r146",
      "r147",
      "r392"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_EarningsPerShareDiluted",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Per diluted share amount, after tax, of income (loss) from the day-to-day business activities of the discontinued operation and gain (loss) from the disposal of the discontinued operation.",
        "label": "Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Diluted Share",
        "terseLabel": "Income from discontinued operations (USD per share)"
       }
      }
     },
     "localname": "IncomeLossFromDiscontinuedOperationsNetOfTaxPerDilutedShare",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_IncomeLossFromEquityMethodInvestments": {
     "auth_ref": [
      "r82",
      "r115",
      "r173",
      "r193",
      "r477",
      "r497"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 5.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This item represents the entity's proportionate share for the period of the net income (loss) of its investee (such as unconsolidated subsidiaries and joint ventures) to which the equity method of accounting is applied. This item includes income or expense related to stock-based compensation based on the investor's grant of stock to employees of an equity method investee.",
        "label": "Income (Loss) from Equity Method Investments",
        "negatedTerseLabel": "Loss on equity investment in Viking"
       }
      }
     },
     "localname": "IncomeLossFromEquityMethodInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeStatementAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Income Statement [Abstract]",
        "terseLabel": "Condensed Statement of Operations:"
       }
      }
     },
     "localname": "IncomeStatementAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncomeStatementLocationAxis": {
     "auth_ref": [
      "r221"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by location in the income statement.",
        "label": "Income Statement Location [Axis]",
        "terseLabel": "Income Statement Location [Axis]"
       }
      }
     },
     "localname": "IncomeStatementLocationAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncomeStatementLocationDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Location in the income statement.",
        "label": "Income Statement Location [Domain]",
        "terseLabel": "Income Statement Location [Domain]"
       }
      }
     },
     "localname": "IncomeStatementLocationDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_IncomeTaxAuthorityAxis": {
     "auth_ref": [
      "r329"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by tax jurisdiction.",
        "label": "Income Tax Authority [Axis]",
        "terseLabel": "Income Tax Authority [Axis]"
       }
      }
     },
     "localname": "IncomeTaxAuthorityAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncomeTaxAuthorityDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Agency, division or body classification that levies income taxes, examines tax returns for compliance, or grants exemptions from or makes other decisions pertaining to income taxes.",
        "label": "Income Tax Authority [Domain]",
        "terseLabel": "Income Tax Authority [Domain]"
       }
      }
     },
     "localname": "IncomeTaxAuthorityDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_IncomeTaxDisclosureAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Income Tax Disclosure [Abstract]"
       }
      }
     },
     "localname": "IncomeTaxDisclosureAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncomeTaxDisclosureTextBlock": {
     "auth_ref": [
      "r355"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.",
        "label": "Income Tax Disclosure [Text Block]",
        "terseLabel": "Income Taxes"
       }
      }
     },
     "localname": "IncomeTaxDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxes"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_IncomeTaxExpenseBenefit": {
     "auth_ref": [
      "r127",
      "r174",
      "r352"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_IncomeLossFromContinuingOperationsIncludingPortionAttributableToNoncontrollingInterest",
       "weight": -1.0
      },
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      },
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations.",
        "label": "Income Tax Expense (Benefit)",
        "negatedLabel": "Income tax expense",
        "negatedTerseLabel": "Income tax (expense) benefit",
        "totalLabel": "Income tax expense from continuing operations"
       }
      }
     },
     "localname": "IncomeTaxExpenseBenefit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/IncomeTaxesComponentsofIncomeTaxExpenseBenefitDetails",
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Effective Income Tax Rate Reconciliation, Amount [Abstract]",
        "terseLabel": "Income Tax Expense (Benefit), Continuing Operations, Income Tax Reconciliation [Abstract]"
       }
      }
     },
     "localname": "IncomeTaxExpenseBenefitContinuingOperationsIncomeTaxReconciliationAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncomeTaxPolicyTextBlock": {
     "auth_ref": [
      "r124",
      "r323",
      "r324",
      "r335",
      "r336",
      "r342",
      "r354",
      "r515"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for income taxes, which may include its accounting policies for recognizing and measuring deferred tax assets and liabilities and related valuation allowances, recognizing investment tax credits, operating loss carryforwards, tax credit carryforwards, and other carryforwards, methodologies for determining its effective income tax rate and the characterization of interest and penalties in the financial statements.",
        "label": "Income Tax, Policy [Policy Text Block]",
        "verboseLabel": "Income Taxes"
       }
      }
     },
     "localname": "IncomeTaxPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance": {
     "auth_ref": [
      "r322",
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 8.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to increase (decrease) in the valuation allowance for deferred tax assets.",
        "label": "Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount",
        "terseLabel": "Change in valuation allowance"
       }
      }
     },
     "localname": "IncomeTaxReconciliationChangeInDeferredTaxAssetsValuationAllowance",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationChangeInEnactedTaxRate": {
     "auth_ref": [
      "r321",
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 7.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations, attributable to increase (decrease) in the income tax rates.",
        "label": "Effective Income Tax Rate Reconciliation, Change in Enacted Tax Rate, Amount",
        "terseLabel": "Rate change for changes in federal or state law"
       }
      }
     },
     "localname": "IncomeTaxReconciliationChangeInEnactedTaxRate",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate": {
     "auth_ref": [
      "r126",
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of income tax expense or benefit for the period computed by applying the domestic federal statutory tax rates to pretax income from continuing operations.",
        "label": "Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount",
        "terseLabel": "Tax at federal statutory rate"
       }
      }
     },
     "localname": "IncomeTaxReconciliationIncomeTaxExpenseBenefitAtFederalStatutoryIncomeTaxRate",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost": {
     "auth_ref": [
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to nondeductible equity-based compensation costs.",
        "label": "Effective Income Tax Rate Reconciliation, Nondeductible Expense, Share-based Compensation Cost, Amount",
        "terseLabel": "Stock-based compensation"
       }
      }
     },
     "localname": "IncomeTaxReconciliationNondeductibleExpenseShareBasedCompensationCost",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationOtherAdjustments": {
     "auth_ref": [
      "r327"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 9.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other adjustments.",
        "label": "Effective Income Tax Rate Reconciliation, Other Adjustments, Amount",
        "terseLabel": "Other"
       }
      }
     },
     "localname": "IncomeTaxReconciliationOtherAdjustments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationStateAndLocalIncomeTaxes": {
     "auth_ref": [
      "r126",
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to state and local income tax expense (benefit).",
        "label": "Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Amount",
        "terseLabel": "State, net of federal benefit"
       }
      }
     },
     "localname": "IncomeTaxReconciliationStateAndLocalIncomeTaxes",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxReconciliationTaxCreditsOther": {
     "auth_ref": [
      "r327",
      "r328"
     ],
     "calculation": {
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails": {
       "order": 11.0,
       "parentTag": "us-gaap_IncomeTaxExpenseBenefit",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to other tax credits.",
        "label": "Effective Income Tax Rate Reconciliation, Tax Credit, Other, Amount",
        "negatedLabel": "Expired NOLs and credits"
       }
      }
     },
     "localname": "IncomeTaxReconciliationTaxCreditsOther",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofIncomeTaxExpenseBenefitDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncomeTaxesPaid": {
     "auth_ref": [
      "r111",
      "r118"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of cash paid during the current period to foreign, federal, state, and local authorities as taxes on income.",
        "label": "Income Taxes Paid",
        "terseLabel": "Taxes paid"
       }
      }
     },
     "localname": "IncomeTaxesPaid",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 14.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the reporting period in the amounts payable to vendors for goods and services received and the amount of obligations and expenses incurred but not paid.",
        "label": "Increase (Decrease) in Accounts Payable and Accrued Liabilities",
        "terseLabel": "Accounts payable and accrued liabilities"
       }
      }
     },
     "localname": "IncreaseDecreaseInAccountsPayableAndAccruedLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInAccountsReceivable": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 11.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the reporting period in amount due within one year (or one business cycle) from customers for the credit sale of goods and services.",
        "label": "Increase (Decrease) in Accounts Receivable",
        "negatedLabel": "Accounts receivable, net"
       }
      }
     },
     "localname": "IncreaseDecreaseInAccountsReceivable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInContractWithCustomerLiability": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 15.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in obligation to transfer good or service to customer for which consideration has been received or is receivable.",
        "label": "Increase (Decrease) in Contract with Customer, Liability",
        "terseLabel": "Deferred revenue"
       }
      }
     },
     "localname": "IncreaseDecreaseInContractWithCustomerLiability",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInDeferredIncomeTaxes": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 10.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the reporting period in the account that represents the temporary difference that results from Income or Loss that is recognized for accounting purposes but not for tax purposes and vice versa.",
        "label": "Increase (Decrease) in Deferred Income Taxes",
        "negatedLabel": "Deferred income taxes"
       }
      }
     },
     "localname": "IncreaseDecreaseInDeferredIncomeTaxes",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInDerivativeAssets": {
     "auth_ref": [
      "r114"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the period in the carrying value of derivative instruments reported as assets that are due to be disposed of within one year (or the normal operating cycle, if longer).",
        "label": "Increase (Decrease) in Derivative Assets",
        "terseLabel": "Increase (decrease) in derivative assets"
       }
      }
     },
     "localname": "IncreaseDecreaseInDerivativeAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInDerivativeLiabilities": {
     "auth_ref": [
      "r114"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the period in the carrying value of derivative instruments reported as liabilities that are due to be disposed of within one year (or the normal operating cycle, if longer).",
        "label": "Increase (Decrease) in Derivative Liabilities",
        "terseLabel": "Increase (decrease) in derivative liabilities"
       }
      }
     },
     "localname": "IncreaseDecreaseInDerivativeLiabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInInventories": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 12.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The increase (decrease) during the reporting period in the aggregate value of all inventory held by the reporting entity, associated with underlying transactions that are classified as operating activities.",
        "label": "Increase (Decrease) in Inventories",
        "negatedLabel": "Inventory"
       }
      }
     },
     "localname": "IncreaseDecreaseInInventories",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInOperatingCapitalAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Increase (Decrease) in Operating Capital [Abstract]",
        "verboseLabel": "Changes in operating assets and liabilities, net of acquisition:"
       }
      }
     },
     "localname": "IncreaseDecreaseInOperatingCapitalAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncreaseDecreaseInOtherNoncurrentAssets": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 19.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in noncurrent assets classified as other.",
        "label": "Increase (Decrease) in Other Noncurrent Assets",
        "negatedLabel": "Other long term assets"
       }
      }
     },
     "localname": "IncreaseDecreaseInOtherNoncurrentAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 13.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in prepaid expenses, and assets classified as other.",
        "label": "Increase (Decrease) in Prepaid Expense and Other Assets",
        "negatedLabel": "Other current assets"
       }
      }
     },
     "localname": "IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IncreaseDecreaseInStockholdersEquityRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Increase (Decrease) in Stockholders' Equity [Roll Forward]",
        "terseLabel": "Increase (Decrease) in Stockholders' Equity [Roll Forward]"
       }
      }
     },
     "localname": "IncreaseDecreaseInStockholdersEquityRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IncrementalCommonSharesAttributableToCallOptionsAndWarrants": {
     "auth_ref": [
      "r148"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": 5.0,
       "parentTag": "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of call options and warrants using the treasury stock method.",
        "label": "Incremental Common Shares Attributable to Dilutive Effect of Call Options and Warrants",
        "terseLabel": "Warrants (shares)"
       }
      }
     },
     "localname": "IncrementalCommonSharesAttributableToCallOptionsAndWarrants",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_IncrementalCommonSharesAttributableToConversionOfDebtSecurities": {
     "auth_ref": [
      "r145",
      "r150"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": 3.0,
       "parentTag": "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of convertible debt securities using the if-converted method.",
        "label": "Incremental Common Shares Attributable to Dilutive Effect of Conversion of Debt Securities",
        "terseLabel": "2019 Convertible Senior Notes (shares)"
       }
      }
     },
     "localname": "IncrementalCommonSharesAttributableToConversionOfDebtSecurities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements": {
     "auth_ref": [
      "r143",
      "r150"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additional shares included in the calculation of diluted EPS as a result of the potentially dilutive effect of share based payment arrangements using the treasury stock method.",
        "label": "Incremental Common Shares Attributable to Dilutive Effect of Share-based Payment Arrangements",
        "terseLabel": "Stock options (shares)"
       }
      }
     },
     "localname": "IncrementalCommonSharesAttributableToShareBasedPaymentArrangements",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_IndefiniteLivedIntangibleAssetsByMajorClassAxis": {
     "auth_ref": [
      "r207",
      "r214"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type or class of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit.",
        "label": "Indefinite-lived Intangible Assets [Axis]",
        "terseLabel": "Indefinite-lived Intangible Assets [Axis]"
       }
      }
     },
     "localname": "IndefiniteLivedIntangibleAssetsByMajorClassAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_IndefiniteLivedIntangibleAssetsExcludingGoodwill": {
     "auth_ref": [
      "r214"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of assets, excluding financial assets and goodwill, lacking physical substance and having a projected indefinite period of benefit.",
        "label": "Indefinite-lived Intangible Assets (Excluding Goodwill)",
        "terseLabel": "IPR&amp;D"
       }
      }
     },
     "localname": "IndefiniteLivedIntangibleAssetsExcludingGoodwill",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IndefiniteLivedIntangibleAssetsMajorClassNameDomain": {
     "auth_ref": [
      "r207",
      "r214"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The major class of indefinite-lived intangible asset (for example, trade names, etc. but not all-inclusive), excluding goodwill. A major class is composed of intangible assets that can be grouped together because they are similar, either by their nature or by their use in the operations of the company.",
        "label": "Indefinite-lived Intangible Assets, Major Class Name [Domain]",
        "terseLabel": "Indefinite-lived Intangible Assets, Major Class Name [Domain]"
       }
      }
     },
     "localname": "IndefiniteLivedIntangibleAssetsMajorClassNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_InitialApplicationPeriodCumulativeEffectTransitionAxis": {
     "auth_ref": [
      "r260"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information about effect of transition method for cumulative effect in initial period of application.",
        "label": "Initial Application Period Cumulative Effect Transition [Axis]",
        "terseLabel": "Initial Application Period Cumulative Effect Transition [Axis]"
       }
      }
     },
     "localname": "InitialApplicationPeriodCumulativeEffectTransitionAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_InitialApplicationPeriodCumulativeEffectTransitionDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Effect of transition method for cumulative effect in initial period of application.",
        "label": "Initial Application Period Cumulative Effect Transition [Domain]",
        "terseLabel": "Initial Application Period Cumulative Effect Transition [Domain]"
       }
      }
     },
     "localname": "InitialApplicationPeriodCumulativeEffectTransitionDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_IntangibleAssetsNetExcludingGoodwill": {
     "auth_ref": [
      "r204",
      "r209"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges.",
        "label": "Intangible Assets, Net (Excluding Goodwill)",
        "verboseLabel": "Intangible assets, net"
       }
      }
     },
     "localname": "IntangibleAssetsNetExcludingGoodwill",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_IntangibleAssetsNetIncludingGoodwill": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying amount of finite-lived intangible assets, indefinite-lived intangible assets and goodwill. Goodwill is an asset representing the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized. Intangible assets are assets, not including financial assets, lacking physical substance.",
        "label": "Intangible Assets, Net (Including Goodwill)",
        "totalLabel": "Total goodwill and other identifiable intangible assets, net"
       }
      }
     },
     "localname": "IntangibleAssetsNetIncludingGoodwill",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InterestExpense": {
     "auth_ref": [
      "r81",
      "r171",
      "r430",
      "r433",
      "r481"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 4.0,
       "parentTag": "us-gaap_NonoperatingIncomeExpense",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of the cost of borrowed funds accounted for as interest expense.",
        "label": "Interest Expense",
        "negatedLabel": "Interest expense"
       }
      }
     },
     "localname": "InterestExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InterestPaidNet": {
     "auth_ref": [
      "r105",
      "r110",
      "r118"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash paid for interest, excluding capitalized interest, classified as operating activity. Includes, but is not limited to, payment to settle zero-coupon bond for accreted interest of debt discount and debt instrument with insignificant coupon interest rate in relation to effective interest rate of borrowing attributable to accreted interest of debt discount.",
        "label": "Interest Paid, Excluding Capitalized Interest, Operating Activities",
        "terseLabel": "Interest paid"
       }
      }
     },
     "localname": "InterestPaidNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InternalRevenueServiceIRSMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Designated tax department of the United States of America government entitled to levy and collect income taxes from the entity.",
        "label": "Internal Revenue Service (IRS) [Member]",
        "terseLabel": "Internal Revenue Service (IRS)"
       }
      }
     },
     "localname": "InternalRevenueServiceIRSMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_InventoryNet": {
     "auth_ref": [
      "r10",
      "r57",
      "r197"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 6.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after valuation and LIFO reserves of inventory expected to be sold, or consumed within one year or operating cycle, if longer.",
        "label": "Inventory, Net",
        "verboseLabel": "Inventory"
       }
      }
     },
     "localname": "InventoryNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InventoryPolicyTextBlock": {
     "auth_ref": [
      "r18",
      "r58",
      "r124",
      "r153",
      "r198",
      "r200"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of inventory accounting policy for inventory classes, including, but not limited to, basis for determining inventory amounts, methods by which amounts are added and removed from inventory classes, loss recognition on impairment of inventories, and situations in which inventories are stated above cost.",
        "label": "Inventory, Policy [Policy Text Block]",
        "verboseLabel": "Inventory"
       }
      }
     },
     "localname": "InventoryPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_InventoryWriteDown": {
     "auth_ref": [
      "r89",
      "r195",
      "r196",
      "r199"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of loss from reductions in inventory due to subsequent measurement adjustments, including, but not limited to, physical deterioration, obsolescence, or changes in price levels.",
        "label": "Inventory Write-down",
        "terseLabel": "Write-downs related to obsolete inventory"
       }
      }
     },
     "localname": "InventoryWriteDown",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InvestmentIncomeNonoperating": {
     "auth_ref": [
      "r91"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 3.0,
       "parentTag": "us-gaap_NonoperatingIncomeExpense",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate amount of income from investments (for example, dividends) not considered a component of the entity's core operations.",
        "label": "Investment Income, Nonoperating",
        "terseLabel": "Interest income"
       }
      }
     },
     "localname": "InvestmentIncomeNonoperating",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_InvestmentTypeAxis": {
     "auth_ref": [
      "r509",
      "r510",
      "r511",
      "r512"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of investments.",
        "label": "Investment Type [Axis]",
        "terseLabel": "Investment Type [Axis]"
       }
      }
     },
     "localname": "InvestmentTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_InvestmentTypeCategorizationMember": {
     "auth_ref": [
      "r509",
      "r510",
      "r511",
      "r512"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Asset obtained to generate income or appreciate in value.",
        "label": "Investments [Domain]",
        "terseLabel": "Investments [Domain]"
       }
      }
     },
     "localname": "InvestmentTypeCategorizationMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_LeaseAndRentalExpense": {
     "auth_ref": [],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of rent expense incurred for leased assets, including but not limited to, furniture and equipment, that is not directly or indirectly associated with the manufacture, sale or creation of a product or product line.",
        "label": "Operating Leases, Rent Expense",
        "terseLabel": "Rent expense"
       }
      }
     },
     "localname": "LeaseAndRentalExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LeaseholdImprovementsMember": {
     "auth_ref": [
      "r218"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Additions or improvements to assets held under a lease arrangement.",
        "label": "Leasehold Improvements [Member]",
        "verboseLabel": "Leasehold improvements"
       }
      }
     },
     "localname": "LeaseholdImprovementsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_LeasesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Leases [Abstract]"
       }
      }
     },
     "localname": "LeasesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_LeasesOfLesseeDisclosureTextBlock": {
     "auth_ref": [
      "r439",
      "r440"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for lessee entity's leasing arrangements including, but not limited to, all of the following: (a.) The basis on which contingent rental payments are determined, (b.) The existence and terms of renewal or purchase options and escalation clauses, (c.) Restrictions imposed by lease agreements, such as those concerning dividends, additional debt, and further leasing.",
        "label": "Leases of Lessee Disclosure [Text Block]",
        "verboseLabel": "Lease Obligations"
       }
      }
     },
     "localname": "LeasesOfLesseeDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligations"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_LeasesOperatingAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Leases, Operating [Abstract]",
        "terseLabel": "Payments expected to received from sublease agreements"
       }
      }
     },
     "localname": "LeasesOperatingAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_LegalMattersAndContingenciesTextBlock": {
     "auth_ref": [
      "r227"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for legal proceedings, legal contingencies, litigation, regulatory and environmental matters and other contingencies.",
        "label": "Legal Matters and Contingencies [Text Block]",
        "terseLabel": "Commitments and Contingencies: Legal Proceedings"
       }
      }
     },
     "localname": "LegalMattersAndContingenciesTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CommitmentsandContingenciesLegalProceedings"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_Liabilities": {
     "auth_ref": [
      "r47"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_LiabilitiesAndStockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Sum of the carrying amounts as of the balance sheet date of all liabilities that are recognized. Liabilities are probable future sacrifices of economic benefits arising from present obligations of an entity to transfer assets or provide services to other entities in the future.",
        "label": "Liabilities",
        "totalLabel": "Total liabilities"
       }
      }
     },
     "localname": "Liabilities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LiabilitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Liabilities [Abstract]",
        "terseLabel": "Liabilities:"
       }
      }
     },
     "localname": "LiabilitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_LiabilitiesAndStockholdersEquity": {
     "auth_ref": [
      "r37",
      "r469",
      "r492"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of liabilities and equity items, including the portion of equity attributable to noncontrolling interests, if any.",
        "label": "Liabilities and Equity",
        "totalLabel": "Total liabilities and stockholders\u2019 equity"
       }
      }
     },
     "localname": "LiabilitiesAndStockholdersEquity",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LiabilitiesAndStockholdersEquityAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Liabilities and Equity [Abstract]",
        "verboseLabel": "LIABILITIES AND STOCKHOLDERS\u2019 EQUITY"
       }
      }
     },
     "localname": "LiabilitiesAndStockholdersEquityAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_LiabilitiesCurrent": {
     "auth_ref": [
      "r49"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_Liabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Total obligations incurred as part of normal operations that are expected to be paid during the following twelve months or within one business cycle, if longer.",
        "label": "Liabilities, Current",
        "totalLabel": "Total current liabilities"
       }
      }
     },
     "localname": "LiabilitiesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LiabilitiesCurrentAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Liabilities, Current [Abstract]",
        "verboseLabel": "Current liabilities:"
       }
      }
     },
     "localname": "LiabilitiesCurrentAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_LiabilitiesFairValueDisclosure": {
     "auth_ref": [
      "r409"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Fair value of financial and nonfinancial obligations.",
        "label": "Financial and Nonfinancial Liabilities, Fair Value Disclosure",
        "verboseLabel": "Liabilities, fair value"
       }
      }
     },
     "localname": "LiabilitiesFairValueDisclosure",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LicensingAgreementsMember": {
     "auth_ref": [
      "r364"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Rights, generally of limited duration, under a license arrangement (for example, to sell or otherwise utilize specified products or processes in a specified territory).",
        "label": "Licensing Agreements [Member]",
        "terseLabel": "Licensing Agreements"
       }
      }
     },
     "localname": "LicensingAgreementsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest": {
     "auth_ref": [
      "r156"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Percentage investment held by members or limited partners of limited liability company (LLC) or limited partnership (LP).",
        "label": "Limited Liability Company or Limited Partnership, Members or Limited Partners, Ownership Interest",
        "terseLabel": "Ownership interest (as a percent)"
       }
      }
     },
     "localname": "LimitedLiabilityCompanyLLCOrLimitedPartnershipLPMembersOrLimitedPartnersOwnershipInterest",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_LongTermNotesPayable": {
     "auth_ref": [
      "r52"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying value as of the balance sheet date of notes payable (with maturities initially due after one year or beyond the operating cycle if longer), excluding current portion.",
        "label": "Notes Payable, Noncurrent",
        "terseLabel": "Total long-term portion of notes payable"
       }
      }
     },
     "localname": "LongTermNotesPayable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_LongtermDebtTypeAxis": {
     "auth_ref": [
      "r52"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of long-term debt.",
        "label": "Long-term Debt, Type [Axis]",
        "terseLabel": "Long-term Debt, Type [Axis]"
       }
      }
     },
     "localname": "LongtermDebtTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_LongtermDebtTypeDomain": {
     "auth_ref": [
      "r52",
      "r229"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Type of long-term debt arrangement, such as notes, line of credit, commercial paper, asset-based financing, project financing, letter of credit financing. These are debt arrangements that originally required repayment more than twelve months after issuance or greater than the normal operating cycle of the company, if longer.",
        "label": "Long-term Debt, Type [Domain]",
        "terseLabel": "Long-term Debt, Type [Domain]"
       }
      }
     },
     "localname": "LongtermDebtTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_LongtermNotesPayableCurrentAndNoncurrentTotalAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Notes Payable, Current and Noncurrent [Abstract]",
        "terseLabel": "Notes Payable, Current and Noncurrent"
       }
      }
     },
     "localname": "LongtermNotesPayableCurrentAndNoncurrentTotalAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_MeasurementInputExpectedDividendRateMember": {
     "auth_ref": [
      "r412"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement input using expected dividend rate to be paid to holder of share per year.",
        "label": "Measurement Input, Expected Dividend Rate [Member]",
        "terseLabel": "Dividend yield"
       }
      }
     },
     "localname": "MeasurementInputExpectedDividendRateMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_MeasurementInputPriceVolatilityMember": {
     "auth_ref": [
      "r412"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement input using rate at which price of security will increase (decrease) for given set of returns.",
        "label": "Measurement Input, Price Volatility [Member]",
        "terseLabel": "Volatility"
       }
      }
     },
     "localname": "MeasurementInputPriceVolatilityMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_MeasurementInputRiskFreeInterestRateMember": {
     "auth_ref": [
      "r412"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement input using interest rate on instrument with zero risk of financial loss.",
        "label": "Measurement Input, Risk Free Interest Rate [Member]",
        "terseLabel": "Risk-free interest rate"
       }
      }
     },
     "localname": "MeasurementInputRiskFreeInterestRateMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_MeasurementInputTypeAxis": {
     "auth_ref": [
      "r412"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of measurement input used to determine value of asset and liability.",
        "label": "Measurement Input Type [Axis]",
        "terseLabel": "Measurement Input Type [Axis]"
       }
      }
     },
     "localname": "MeasurementInputTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_MeasurementInputTypeDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Measurement input used to determine value of asset and liability.",
        "label": "Measurement Input Type [Domain]",
        "terseLabel": "Measurement Input Type [Domain]"
       }
      }
     },
     "localname": "MeasurementInputTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_MunicipalBondsMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Long-term debt securities issued by state, city or local governments or the agencies operated by state, city or local governments.",
        "label": "Municipal Bonds [Member]",
        "terseLabel": "Municipal bonds"
       }
      }
     },
     "localname": "MunicipalBondsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_NetCashProvidedByUsedInFinancingActivities": {
     "auth_ref": [
      "r107"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 3.0,
       "parentTag": "us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash inflow (outflow) from financing activities, including discontinued operations. Financing activity cash flows include obtaining resources from owners and providing them with a return on, and a return of, their investment; borrowing money and repaying amounts borrowed, or settling the obligation; and obtaining and paying for other resources obtained from creditors on long-term credit.",
        "label": "Net Cash Provided by (Used in) Financing Activities",
        "terseLabel": "Net cash provided by financing activities",
        "totalLabel": "Net cash (used in) provided by financing activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInFinancingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Net Cash Provided by (Used in) Financing Activities [Abstract]",
        "verboseLabel": "Financing activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInFinancingActivitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_NetCashProvidedByUsedInInvestingActivities": {
     "auth_ref": [
      "r107"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 2.0,
       "parentTag": "us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash inflow (outflow) from investing activities, including discontinued operations. Investing activity cash flows include making and collecting loans and acquiring and disposing of debt or equity instruments and property, plant, and equipment and other productive assets.",
        "label": "Net Cash Provided by (Used in) Investing Activities",
        "terseLabel": "Net cash used in investing activities",
        "totalLabel": "Net cash used in investing activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInInvestingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Net Cash Provided by (Used in) Investing Activities [Abstract]",
        "verboseLabel": "Investing activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInInvestingActivitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_NetCashProvidedByUsedInOperatingActivities": {
     "auth_ref": [
      "r107",
      "r112",
      "r116"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 1.0,
       "parentTag": "us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities.",
        "label": "Net Cash Provided by (Used in) Operating Activities",
        "terseLabel": "Net cash provided by operating activities",
        "totalLabel": "Net cash provided by operating activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInOperatingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Net Cash Provided by (Used in) Operating Activities [Abstract]",
        "verboseLabel": "Operating activities"
       }
      }
     },
     "localname": "NetCashProvidedByUsedInOperatingActivitiesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_NetIncomeLoss": {
     "auth_ref": [
      "r73",
      "r76",
      "r84",
      "r116",
      "r150",
      "r479",
      "r500"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS": {
       "order": 1.0,
       "parentTag": "us-gaap_ComprehensiveIncomeNetOfTax",
       "weight": 1.0
      },
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.",
        "label": "Net Income (Loss) Attributable to Parent",
        "terseLabel": "Net Income (loss)",
        "totalLabel": "Net income (loss)",
        "verboseLabel": "Net income (loss)"
       }
      }
     },
     "localname": "NetIncomeLoss",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy pertaining to new accounting pronouncements that may impact the entity's financial reporting. Includes, but is not limited to, quantification of the expected or actual impact.",
        "label": "New Accounting Pronouncements, Policy [Policy Text Block]",
        "terseLabel": "Accounting Standards Recently Adopted and Accounting Standards Not Yet Adopted"
       }
      }
     },
     "localname": "NewAccountingPronouncementsPolicyPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_NonoperatingIncomeExpense": {
     "auth_ref": [
      "r91"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate amount of income or expense from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business).",
        "label": "Nonoperating Income (Expense)",
        "totalLabel": "Total other income (expense), net"
       }
      }
     },
     "localname": "NonoperatingIncomeExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NotesAndLoansReceivableGrossCurrent": {
     "auth_ref": [
      "r11",
      "r12",
      "r56",
      "r181"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 5.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "An amount representing an agreement for an unconditional promise by the maker to pay the Entity (holder) a definite sum of money at a future date(s) within one year of the balance sheet date or the normal operating cycle, whichever is longer. Such amount may include accrued interest receivable in accordance with the terms of the debt. The debt also may contain provisions including a discount or premium, payable on demand, secured, or unsecured, interest bearing or noninterest bearing, among a myriad of other features and characteristics. This amount does not include amounts related to receivables held-for-sale.",
        "label": "Notes, Loans and Financing Receivable, Gross, Current",
        "terseLabel": "Note receivable from Viking"
       }
      }
     },
     "localname": "NotesAndLoansReceivableGrossCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NotesPayableCurrent": {
     "auth_ref": [
      "r46"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Sum of the carrying values as of the balance sheet date of the portions of long-term notes payable due within one year or the operating cycle if longer.",
        "label": "Notes Payable, Current",
        "terseLabel": "Total current portion of notes payable"
       }
      }
     },
     "localname": "NotesPayableCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesEquityandLiabilityComponentsofFinancingArrangementsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_NotesReceivableMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "An amount representing an agreement for an unconditional promise by the maker to pay the Entity (holder) a definite sum of money at a future date(s) within one year of the balance sheet date. Such amount may include accrued interest receivable in accordance with the terms of the note. The note also may contain provisions including a discount or premium, payable on demand, secured, or unsecured, interest bearing or noninterest bearing, among myriad other features and characteristics.",
        "label": "Notes Receivable [Member]",
        "terseLabel": "Notes receivable Viking"
       }
      }
     },
     "localname": "NotesReceivableMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_OfficeEquipmentMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tangible personal property used in an office setting. Examples include, but are not limited to, computers, copiers and fax machine.",
        "label": "Office Equipment [Member]",
        "verboseLabel": "Lab and office equipment"
       }
      }
     },
     "localname": "OfficeEquipmentMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_OperatingCostsAndExpenses": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_OperatingIncomeLoss",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Generally recurring costs associated with normal operations except for the portion of these expenses which can be clearly related to production and included in cost of sales or services. Excludes Selling, General and Administrative Expense.",
        "label": "Operating Costs and Expenses",
        "terseLabel": "Total operating costs and expenses",
        "totalLabel": "Total operating costs and expenses"
       }
      }
     },
     "localname": "OperatingCostsAndExpenses",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingCostsAndExpensesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Operating Costs and Expenses [Abstract]",
        "verboseLabel": "Operating costs and expenses:"
       }
      }
     },
     "localname": "OperatingCostsAndExpensesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_OperatingIncomeLoss": {
     "auth_ref": [],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesMinorityInterestAndIncomeLossFromEquityMethodInvestments",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The net result for the period of deducting operating expenses from operating revenues.",
        "label": "Operating Income (Loss)",
        "totalLabel": "Income from operations"
       }
      }
     },
     "localname": "OperatingIncomeLoss",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingLeasedAssetsLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Operating Leased Assets [Line Items]",
        "terseLabel": "Operating Leased Assets [Line Items]"
       }
      }
     },
     "localname": "OperatingLeasedAssetsLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_OperatingLeasesFutureMinimumPaymentsDue": {
     "auth_ref": [
      "r435",
      "r436"
     ],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 1.0,
       "parentTag": "lgnd_OperatingLeasesFutureMinimumPaymentsDueNet",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of required minimum rental payments for leases having an initial or remaining non-cancelable letter-terms in excess of one year.",
        "label": "Operating Leases, Future Minimum Payments Due",
        "totalLabel": "Operating lease obligation, Total"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingLeasesFutureMinimumPaymentsDueCurrent": {
     "auth_ref": [
      "r435",
      "r436"
     ],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_OperatingLeasesFutureMinimumPaymentsDue",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of required minimum rental payments for operating leases having an initial or remaining non-cancelable lease term in excess of one year due in the next fiscal year following the latest fiscal year. Excludes interim and annual periods when interim periods are reported on a rolling approach, from latest balance sheet date.",
        "label": "Operating Leases, Future Minimum Payments Due, Next Twelve Months",
        "terseLabel": "Operating lease obligation, Less than 1 year"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals": {
     "auth_ref": [
      "r437"
     ],
     "calculation": {
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails": {
       "order": 2.0,
       "parentTag": "lgnd_OperatingLeasesFutureMinimumPaymentsDueNet",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contractually required future rental payments receivable on noncancelable subleasing arrangements.",
        "label": "Operating Leases, Future Minimum Payments Due, Future Minimum Sublease Rentals",
        "totalLabel": "Sublease payments expected to be received, Total"
       }
      }
     },
     "localname": "OperatingLeasesFutureMinimumPaymentsDueFutureMinimumSubleaseRentals",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingLossCarryforwards": {
     "auth_ref": [
      "r343"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.",
        "label": "Operating Loss Carryforwards",
        "terseLabel": "Operating loss carryforward"
       }
      }
     },
     "localname": "OperatingLossCarryforwards",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OperatingLossCarryforwardsLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Operating Loss Carryforwards [Line Items]",
        "terseLabel": "Operating Loss Carryforwards [Line Items]"
       }
      }
     },
     "localname": "OperatingLossCarryforwardsLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_OperatingLossCarryforwardsTable": {
     "auth_ref": [
      "r344"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule reflecting pertinent information, such as tax authority, amounts, and expiration dates, of net operating loss carryforwards, including an assessment of the likelihood of utilization.",
        "label": "Operating Loss Carryforwards [Table]",
        "terseLabel": "Operating Loss Carryforwards [Table]"
       }
      }
     },
     "localname": "OperatingLossCarryforwardsTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Organization, Consolidation and Presentation of Financial Statements [Abstract]",
        "terseLabel": "Organization, Consolidation and Presentation of Financial Statements [Abstract]"
       }
      }
     },
     "localname": "OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock": {
     "auth_ref": [
      "r8",
      "r136",
      "r170",
      "r393"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for the organization, consolidation and basis of presentation of financial statements disclosure, and significant accounting policies of the reporting entity. May be provided in more than one note to the financial statements, as long as users are provided with an understanding of (1) the significant judgments and assumptions made by an enterprise in determining whether it must consolidate a VIE and/or disclose information about its involvement with a VIE, (2) the nature of restrictions on a consolidated VIE's assets reported by an enterprise in its statement of financial position, including the carrying amounts of such assets, (3) the nature of, and changes in, the risks associated with an enterprise's involvement with the VIE, and (4) how an enterprise's involvement with the VIE affects the enterprise's financial position, financial performance, and cash flows.  Describes procedure if disclosures are provided in more than one note to the financial statements.",
        "label": "Organization, Consolidation and Presentation of Financial Statements Disclosure and Significant Accounting Policies [Text Block]",
        "terseLabel": "Basis of Presentation and Summary of Significant Accounting Policies"
       }
      }
     },
     "localname": "OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureAndSignificantAccountingPoliciesTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_OtherAccruedLiabilitiesCurrent": {
     "auth_ref": [
      "r15",
      "r16",
      "r17",
      "r48"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 7.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of expenses incurred but not yet paid classified as other, due within one year or the normal operating cycle, if longer.",
        "label": "Other Accrued Liabilities, Current",
        "terseLabel": "Other"
       }
      }
     },
     "localname": "OtherAccruedLiabilitiesCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherAssetsCurrent": {
     "auth_ref": [
      "r59"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      },
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 8.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of current assets classified as other.",
        "label": "Other Assets, Current",
        "totalLabel": "Other current assets",
        "verboseLabel": "Other current assets"
       }
      }
     },
     "localname": "OtherAssetsCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherAssetsNoncurrent": {
     "auth_ref": [
      "r44"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 7.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of noncurrent assets classified as other.",
        "label": "Other Assets, Noncurrent",
        "verboseLabel": "Other assets"
       }
      }
     },
     "localname": "OtherAssetsNoncurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax": {
     "auth_ref": [
      "r65"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS": {
       "order": 2.0,
       "parentTag": "us-gaap_ComprehensiveIncomeNetOfTax",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax and reclassification adjustments, of appreciation (loss) in value of unsold available-for-sale securities. Excludes amounts related to other than temporary impairment (OTTI) loss.",
        "label": "Other Comprehensive Income (Loss), Securities, Available-for-sale, Adjustment, after Tax",
        "terseLabel": "Unrealized net gain on available-for-sale securities, net of tax"
       }
      }
     },
     "localname": "OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax": {
     "auth_ref": [
      "r64",
      "r428"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS": {
       "order": 3.0,
       "parentTag": "us-gaap_ComprehensiveIncomeNetOfTax",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax and reclassification adjustments of gain (loss) on foreign currency translation adjustments, foreign currency transactions designated and effective as economic hedges of a net investment in a foreign entity and intra-entity foreign currency transactions that are of a long-term-investment nature.",
        "label": "Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Adjustment, Net of Tax",
        "terseLabel": "Foreign currency translation"
       }
      }
     },
     "localname": "OtherComprehensiveIncomeLossForeignCurrencyTransactionAndTranslationAdjustmentNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherComprehensiveIncomeLossNetOfTax": {
     "auth_ref": [
      "r74",
      "r77",
      "r79",
      "r239"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax and reclassification adjustments of other comprehensive income (loss).",
        "label": "Other Comprehensive Income (Loss), Net of Tax",
        "terseLabel": "Other comprehensive income (loss)"
       }
      }
     },
     "localname": "OtherComprehensiveIncomeLossNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax": {
     "auth_ref": [
      "r67",
      "r70",
      "r71",
      "r189"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS": {
       "order": 4.0,
       "parentTag": "us-gaap_ComprehensiveIncomeNetOfTax",
       "weight": -1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after tax of reclassification adjustment from accumulated other comprehensive income for unrealized gain (loss) realized upon the sale of available-for-sale securities.",
        "label": "Other Comprehensive Income (Loss), Reclassification Adjustment from AOCI for Sale of Securities, Net of Tax",
        "negatedTerseLabel": "Less:Reclassification of net realized gains included in net income (loss), net of tax"
       }
      }
     },
     "localname": "OtherComprehensiveIncomeLossReclassificationAdjustmentFromAOCIForSaleOfSecuritiesNetOfTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMELOSS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherLiabilitiesNoncurrent": {
     "auth_ref": [
      "r53"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_Liabilities",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of liabilities classified as other, due after one year or the normal operating cycle, if longer.",
        "label": "Other Liabilities, Noncurrent",
        "verboseLabel": "Other long-term liabilities"
       }
      }
     },
     "localname": "OtherLiabilitiesNoncurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherNonoperatingIncomeExpense": {
     "auth_ref": [
      "r92"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_NonoperatingIncomeExpense",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of income (expense) related to nonoperating activities, classified as other.",
        "label": "Other Nonoperating Income (Expense)",
        "verboseLabel": "Other income (expense), net"
       }
      }
     },
     "localname": "OtherNonoperatingIncomeExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_OtherNonoperatingIncomeExpenseAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Other Nonoperating Income (Expense) [Abstract]",
        "verboseLabel": "Other income (expense):"
       }
      }
     },
     "localname": "OtherNonoperatingIncomeExpenseAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_OtherSignificantNoncashTransactionValueOfConsiderationReceived1": {
     "auth_ref": [
      "r119",
      "r120",
      "r121"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The value of the noncash (or part noncash) consideration received in a transaction. Noncash is defined as transactions during a period that do not result in cash receipts or cash payments in the period. \"Part noncash\" refers to that portion of a transaction not resulting in cash receipts or cash payments in the period.",
        "label": "Other Significant Noncash Transaction, Value of Consideration Received",
        "terseLabel": "Value of consideration received for repayment of convertible notes"
       }
      }
     },
     "localname": "OtherSignificantNoncashTransactionValueOfConsiderationReceived1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PatentedTechnologyMember": {
     "auth_ref": [
      "r365"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Exclusive legal right granted by the government to the owner of the patented technology to exploit the technology for a period of time specified by law.",
        "label": "Patented Technology [Member]",
        "verboseLabel": "Complete technology"
       }
      }
     },
     "localname": "PatentedTechnologyMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_PaymentsForHedgeFinancingActivities": {
     "auth_ref": [
      "r104",
      "r113"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 7.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow for a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations.",
        "label": "Payments for Hedge, Financing Activities",
        "negatedLabel": "Payments to convert holders for bond conversion"
       }
      }
     },
     "localname": "PaymentsForHedgeFinancingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsForRepurchaseOfCommonStock": {
     "auth_ref": [
      "r101"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 10.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow to reacquire common stock during the period.",
        "label": "Payments for Repurchase of Common Stock",
        "negatedLabel": "Share repurchases"
       }
      }
     },
     "localname": "PaymentsForRepurchaseOfCommonStock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsForRepurchaseOfWarrants": {
     "auth_ref": [
      "r101"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 11.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate amount paid by the entity to reacquire the right to purchase equity shares at a predetermined price, usually issued together with corporate debt.",
        "label": "Payments for Repurchase of Warrants",
        "negatedLabel": "Repurchase of warrants",
        "terseLabel": "Payments for repurchase of warrants"
       }
      }
     },
     "localname": "PaymentsForRepurchaseOfWarrants",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsOfDebtIssuanceCosts": {
     "auth_ref": [
      "r103"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 3.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow paid to third parties in connection with debt origination, which will be amortized over the remaining maturity period of the associated long-term debt.",
        "label": "Payments of Debt Issuance Costs",
        "negatedLabel": "Payment of debt issuance costs"
       }
      }
     },
     "localname": "PaymentsOfDebtIssuanceCosts",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation": {
     "auth_ref": [
      "r101",
      "r267"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 9.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash outflow to satisfy an employee's income tax withholding obligation as part of a net-share settlement of a share-based award.",
        "label": "Payments Related to Tax Withholding for Share-based Compensation",
        "negatedTerseLabel": "Taxes paid related to net share settlement of equity awards"
       }
      }
     },
     "localname": "PaymentsRelatedToTaxWithholdingForShareBasedCompensation",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsToAcquireBusinessesGross": {
     "auth_ref": [
      "r95",
      "r370"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow associated with the acquisition of business during the period. The cash portion only of the acquisition price.",
        "label": "Payments to Acquire Businesses, Gross",
        "terseLabel": "Cash consideration",
        "verboseLabel": "Gross payments to acquire business"
       }
      }
     },
     "localname": "PaymentsToAcquireBusinessesGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired": {
     "auth_ref": [
      "r95"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 2.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow associated with the acquisition of a business, net of the cash acquired from the purchase.",
        "label": "Payments to Acquire Businesses, Net of Cash Acquired",
        "negatedTerseLabel": "Cash paid for acquisition, net of cash acquired"
       }
      }
     },
     "localname": "PaymentsToAcquireBusinessesNetOfCashAcquired",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsToAcquireEquityMethodInvestments": {
     "auth_ref": [
      "r95"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 9.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow associated with the purchase of or advances to an equity method investments, which are investments in joint ventures and entities in which the entity has an equity ownership interest normally of 20 to 50 percent and exercises significant influence.",
        "label": "Payments to Acquire Equity Method Investments",
        "negatedTerseLabel": "Common stock and warrants in equity method investments"
       }
      }
     },
     "localname": "PaymentsToAcquireEquityMethodInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsToAcquirePropertyPlantAndEquipment": {
     "auth_ref": [
      "r96"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 3.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets.",
        "label": "Payments to Acquire Property, Plant, and Equipment",
        "negatedLabel": "Purchases of property and equipment"
       }
      }
     },
     "localname": "PaymentsToAcquirePropertyPlantAndEquipment",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PaymentsToAcquireShortTermInvestments": {
     "auth_ref": [
      "r97"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 4.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow for securities or other assets acquired, which qualify for treatment as an investing activity and are to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.",
        "label": "Payments to Acquire Short-term Investments",
        "negatedTerseLabel": "Purchases of short-term investments"
       }
      }
     },
     "localname": "PaymentsToAcquireShortTermInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PlanNameAxis": {
     "auth_ref": [
      "r272",
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by plan name pertaining to equity-based compensation arrangements.",
        "label": "Plan Name [Axis]",
        "terseLabel": "Plan Name [Axis]"
       }
      }
     },
     "localname": "PlanNameAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_PlanNameDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Name of the equity-based compensation arrangement plan.",
        "label": "Plan Name [Domain]",
        "terseLabel": "Plan Name [Domain]"
       }
      }
     },
     "localname": "PlanNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_PriorPeriodReclassificationAdjustmentDescription": {
     "auth_ref": [
      "r0"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for reclassifications that affects the comparability of the financial statements.",
        "label": "Reclassification, Policy [Policy Text Block]",
        "terseLabel": "Reclassifications"
       }
      }
     },
     "localname": "PriorPeriodReclassificationAdjustmentDescription",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ProceedsFromCollectionOfNotesReceivable": {
     "auth_ref": [
      "r93"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 7.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow associated with principal collections from a borrowing supported by a written promise to pay an obligation.",
        "label": "Proceeds from Collection of Notes Receivable",
        "terseLabel": "Proceeds received from repayment of Viking note receivable"
       }
      }
     },
     "localname": "ProceedsFromCollectionOfNotesReceivable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromDebtNetOfIssuanceCosts": {
     "auth_ref": [
      "r99"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from additional borrowings, net of cash paid to third parties in connection with debt origination.",
        "label": "Proceeds from Debt, Net of Issuance Costs",
        "terseLabel": "Net proceeds from debt issuance"
       }
      }
     },
     "localname": "ProceedsFromDebtNetOfIssuanceCosts",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromDerivativeInstrumentInvestingActivities": {
     "auth_ref": [
      "r94"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow provided by derivative instruments during the period, which are classified as investing activities, excluding those designated as hedging instruments.",
        "label": "Proceeds from Derivative Instrument, Investing Activities",
        "terseLabel": "Proceeds from derivative instrument"
       }
      }
     },
     "localname": "ProceedsFromDerivativeInstrumentInvestingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromHedgeFinancingActivities": {
     "auth_ref": [
      "r100",
      "r113"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 6.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from a financial contract that meets the hedge criteria as either cash flow hedge, fair value hedge or hedge of net investment in foreign operations.",
        "label": "Proceeds from Hedge, Financing Activities",
        "terseLabel": "Proceeds from bond hedge"
       }
      }
     },
     "localname": "ProceedsFromHedgeFinancingActivities",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions": {
     "auth_ref": [
      "r98",
      "r302"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash inflow from issuance of shares under share-based compensation arrangement. Issuance includes, but is not limited to, exercise of stock options and similar instruments.",
        "label": "Proceeds from Issuance of Shares under Incentive and Share-based Compensation Plans, Including Stock Options",
        "verboseLabel": "Cash received from options exercised"
       }
      }
     },
     "localname": "ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromIssuanceOfWarrants": {
     "auth_ref": [
      "r98"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 4.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from issuance of rights to purchase common shares at predetermined price (usually issued together with corporate debt).",
        "label": "Proceeds from Issuance of Warrants",
        "terseLabel": "Proceeds from issuance of warrants"
       }
      }
     },
     "localname": "ProceedsFromIssuanceOfWarrants",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromLicenseFeesReceived": {
     "auth_ref": [
      "r108"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 8.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cash received from licensees for license fees during the current period.",
        "label": "Proceeds from License Fees Received",
        "terseLabel": "Proceeds from commercial license rights"
       }
      }
     },
     "localname": "ProceedsFromLicenseFeesReceived",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments": {
     "auth_ref": [
      "r94",
      "r97"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 6.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from maturities, prepayments, calls and collections of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.",
        "label": "Proceeds from Maturities, Prepayments and Calls of Short-term Investments",
        "terseLabel": "Proceeds from maturity of short-term investments"
       }
      }
     },
     "localname": "ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromNotesPayable": {
     "auth_ref": [
      "r99"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 2.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from a borrowing supported by a written promise to pay an obligation.",
        "label": "Proceeds from Notes Payable",
        "terseLabel": "Gross proceeds from issuance of 2023 Convertible Senior Notes"
       }
      }
     },
     "localname": "ProceedsFromNotesPayable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromRoyaltiesReceived": {
     "auth_ref": [
      "r109"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Cash received for royalties during the current period.",
        "label": "Proceeds from Royalties Received",
        "terseLabel": "Proceeds from royalties received"
       }
      }
     },
     "localname": "ProceedsFromRoyaltiesReceived",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromSaleOfShortTermInvestments": {
     "auth_ref": [
      "r94"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 5.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInInvestingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash inflow from sales of all investments, including securities and other assets, having ready marketability and intended by management to be liquidated, if necessary, within the current operating cycle. Includes cash flows from securities classified as trading securities that were acquired for reasons other than sale in the short-term.",
        "label": "Proceeds from Sale of Short-term Investments",
        "verboseLabel": "Proceeds from sale of short-term investments"
       }
      }
     },
     "localname": "ProceedsFromSaleOfShortTermInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProceedsFromStockOptionsExercised": {
     "auth_ref": [
      "r98",
      "r302"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 8.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement.",
        "label": "Proceeds from Stock Options Exercised",
        "terseLabel": "Net proceeds from stock option exercises and ESPP"
       }
      }
     },
     "localname": "ProceedsFromStockOptionsExercised",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ProfitLoss": {
     "auth_ref": [
      "r73",
      "r76",
      "r106",
      "r175",
      "r177",
      "r375",
      "r377",
      "r378",
      "r388",
      "r389"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest.",
        "label": "Net Income (Loss), Including Portion Attributable to Noncontrolling Interest",
        "totalLabel": "Net income (loss)"
       }
      }
     },
     "localname": "ProfitLoss",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentByTypeAxis": {
     "auth_ref": [
      "r43",
      "r220"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of long-lived, physical assets used to produce goods and services and not intended for resale.",
        "label": "Property, Plant and Equipment, Type [Axis]",
        "terseLabel": "Property, Plant and Equipment, Type [Axis]"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentByTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentGross": {
     "auth_ref": [
      "r42",
      "r218"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_PropertyPlantAndEquipmentNet",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.",
        "label": "Property, Plant and Equipment, Gross",
        "verboseLabel": "Property and equipment , gross"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Property, Plant and Equipment [Line Items]",
        "terseLabel": "Property, Plant and Equipment [Line Items]"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentNet": {
     "auth_ref": [
      "r21",
      "r22",
      "r220",
      "r494"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      },
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 3.0,
       "parentTag": "us-gaap_Assets",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount after accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business to produce goods and services and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.",
        "label": "Property, Plant and Equipment, Net",
        "totalLabel": "Property and equipment, net",
        "verboseLabel": "Property and equipment, net"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentNet",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentPolicyTextBlock": {
     "auth_ref": [
      "r41",
      "r124",
      "r220"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for long-lived, physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, basis of assets, depreciation and depletion methods used, including composite deprecation, estimated useful lives, capitalization policy, accounting treatment for costs incurred for repairs and maintenance, capitalized interest and the method it is calculated, disposals and impairments.",
        "label": "Property, Plant and Equipment, Policy [Policy Text Block]",
        "terseLabel": "Property and Equipment"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentTextBlock": {
     "auth_ref": [
      "r21",
      "r220"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation.",
        "label": "Property, Plant and Equipment [Table Text Block]",
        "terseLabel": "Schedule of Property and Equipment"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentTypeDomain": {
     "auth_ref": [
      "r21",
      "r218"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Listing of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. Examples include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software.",
        "label": "Property, Plant and Equipment, Type [Domain]",
        "terseLabel": "Property, Plant and Equipment, Type [Domain]"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_PropertyPlantAndEquipmentUsefulLife": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Useful life of long lived, physical assets used in the normal conduct of business and not intended for resale, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days. Examples include, but not limited to, land, buildings, machinery and equipment, office equipment, furniture and fixtures, and computer equipment.",
        "label": "Property, Plant and Equipment, Useful Life",
        "terseLabel": "Property and equipment, useful life"
       }
      }
     },
     "localname": "PropertyPlantAndEquipmentUsefulLife",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_QuarterlyFinancialInformationDisclosureAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Quarterly Financial Information Disclosure [Abstract]"
       }
      }
     },
     "localname": "QuarterlyFinancialInformationDisclosureAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_QuarterlyFinancialInformationTextBlock": {
     "auth_ref": [
      "r155"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for quarterly financial data. Includes, but is not limited to, tabular presentation of financial information for fiscal quarters, effect of year-end adjustments, and an explanation of matters or transactions that affect comparability of the information.",
        "label": "Quarterly Financial Information [Text Block]",
        "terseLabel": "Summary of Unaudited Quarterly Financial Information"
       }
      }
     },
     "localname": "QuarterlyFinancialInformationTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformation"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_RealizedInvestmentGainsLosses": {
     "auth_ref": [
      "r502"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 3.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The net realized gains or losses on investments during the period, not including gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity.",
        "label": "Realized Investment Gains (Losses)",
        "negatedTerseLabel": "Realized gain on sale of short-term investment"
       }
      }
     },
     "localname": "RealizedInvestmentGainsLosses",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ReceivablesNetCurrent": {
     "auth_ref": [
      "r32",
      "r38",
      "r493",
      "r507"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The total amount due to the entity within one year of the balance sheet date (or one operating cycle, if longer) from outside sources, including trade accounts receivable, notes and loans receivable, as well as any other types of receivables, net of allowances established for the purpose of reducing such receivables to an amount that approximates their net realizable value.",
        "label": "Receivables, Net, Current",
        "verboseLabel": "Accounts receivable, net"
       }
      }
     },
     "localname": "ReceivablesNetCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]",
        "terseLabel": "Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]"
       }
      }
     },
     "localname": "ReconciliationOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_RelatedPartyDomain": {
     "auth_ref": [
      "r444"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Related parties include affiliates; other entities for which investments are accounted for by the equity method by the entity; trusts for benefit of employees; and principal owners, management, and members of immediate families. It also may include other parties with which the entity may control or can significantly influence the management or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate interests.",
        "label": "Related Party [Domain]",
        "terseLabel": "Related Party [Domain]"
       }
      }
     },
     "localname": "RelatedPartyDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_RelatedPartyTransactionsByRelatedPartyAxis": {
     "auth_ref": [
      "r265",
      "r441",
      "r443",
      "r452",
      "r453",
      "r454",
      "r455",
      "r456",
      "r457",
      "r458",
      "r459",
      "r460",
      "r461",
      "r462",
      "r463"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by type of related party. Related parties include, but not limited to, affiliates; other entities for which investments are accounted for by the equity method by the entity; trusts for benefit of employees; and principal owners, management, and members of immediate families. It also may include other parties with which the entity may control or can significantly influence the management or operating policies of the other to an extent that one of the transacting parties might be prevented from fully pursuing its own separate interests.",
        "label": "Related Party [Axis]",
        "terseLabel": "Related Party [Axis]"
       }
      }
     },
     "localname": "RelatedPartyTransactionsByRelatedPartyAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_RepaymentsOfLongTermDebt": {
     "auth_ref": [
      "r102"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 1.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInFinancingActivities",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer.",
        "label": "Repayments of Long-term Debt",
        "negatedLabel": "Repayments of debt"
       }
      }
     },
     "localname": "RepaymentsOfLongTermDebt",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ResearchAndDevelopmentExpense": {
     "auth_ref": [
      "r316",
      "r518"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 1.0,
       "parentTag": "us-gaap_OperatingCostsAndExpenses",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.",
        "label": "Research and Development Expense",
        "verboseLabel": "Research and development"
       }
      }
     },
     "localname": "ResearchAndDevelopmentExpense",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ResearchAndDevelopmentExpenseMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Primary financial statement caption in which the reported facts about research and development expense have been included.",
        "label": "Research and Development Expense [Member]",
        "terseLabel": "Research and development expenses"
       }
      }
     },
     "localname": "ResearchAndDevelopmentExpenseMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ResearchAndDevelopmentExpensePolicy": {
     "auth_ref": [
      "r124",
      "r316"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for costs it has incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process.",
        "label": "Research and Development Expense, Policy [Policy Text Block]",
        "terseLabel": "Research and Development Expenses"
       }
      }
     },
     "localname": "ResearchAndDevelopmentExpensePolicy",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ResearchMember": {
     "auth_ref": [
      "r344"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Research tax credit carryforwards arising from certain qualifying expenditures incurred to develop new products and processes.",
        "label": "Research Tax Credit Carryforward [Member]",
        "terseLabel": "Research Tax Credit Carryforward"
       }
      }
     },
     "localname": "ResearchMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_RestrictedCashCurrent": {
     "auth_ref": [
      "r9",
      "r19",
      "r122"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails": {
       "order": 1.0,
       "parentTag": "us-gaap_OtherAssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of cash restricted as to withdrawal or usage, classified as current. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits.",
        "label": "Restricted Cash, Current",
        "terseLabel": "Restricted cash"
       }
      }
     },
     "localname": "RestrictedCashCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsOtherCurrentAssetsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_RestrictedStockMember": {
     "auth_ref": [
      "r149"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Stock including a provision that prohibits sale or substantive sale of an equity instrument for a specified period of time or until specified performance conditions are met.",
        "label": "Restricted Stock [Member]",
        "terseLabel": "Restricted Stock"
       }
      }
     },
     "localname": "RestrictedStockMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_RestructuringReserve": {
     "auth_ref": [
      "r223",
      "r224"
     ],
     "calculation": {
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails": {
       "order": 12.0,
       "parentTag": "us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet",
       "weight": -1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying amount (including both current and noncurrent portions of the accrual) as of the balance sheet date pertaining to a specified type of cost associated with exit from or disposal of business activities or restructuring pursuant to a duly authorized plan.",
        "label": "Restructuring Reserve",
        "negatedLabel": "Restructuring and product reserves"
       }
      }
     },
     "localname": "RestructuringReserve",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_RestructuringReserveCurrent": {
     "auth_ref": [
      "r222",
      "r225"
     ],
     "calculation": {
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails": {
       "order": 8.0,
       "parentTag": "us-gaap_AccruedLiabilitiesCurrent",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Carrying amount as of the balance sheet date of known and estimated obligations associated with exit from or disposal of business activities or restructurings pursuant to a duly authorized plan, which are expected to be paid in the next twelve months or in the normal operating cycle if longer. Costs of such activities include those for one-time termination benefits, termination of an operating lease or other contract, consolidating or closing facilities, relocating employees, and costs associated with an ongoing benefit arrangement, but excludes costs associated with the retirement of a long-lived asset.",
        "label": "Restructuring Reserve, Current",
        "terseLabel": "Restructuring"
       }
      }
     },
     "localname": "RestructuringReserveCurrent",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsAccruedLiabilitiesDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_RetainedEarningsAccumulatedDeficit": {
     "auth_ref": [
      "r34",
      "r245",
      "r491"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 1.0,
       "parentTag": "us-gaap_StockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cumulative amount of the reporting entity's undistributed earnings or deficit.",
        "label": "Retained Earnings (Accumulated Deficit)",
        "terseLabel": "Retained earnings (accumulated deficit)",
        "verboseLabel": "Accumulated deficit"
       }
      }
     },
     "localname": "RetainedEarningsAccumulatedDeficit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_RetainedEarningsMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The cumulative amount of the reporting entity's undistributed earnings or deficit.",
        "label": "Retained Earnings [Member]",
        "terseLabel": "Accumulated deficit",
        "verboseLabel": "Retained Earnings"
       }
      }
     },
     "localname": "RetainedEarningsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax": {
     "auth_ref": [
      "r251",
      "r252",
      "r253"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS": {
       "order": 2.0,
       "parentTag": "us-gaap_OperatingIncomeLoss",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.",
        "label": "Revenue from Contract with Customer, Excluding Assessed Tax",
        "terseLabel": "Total revenues"
       }
      }
     },
     "localname": "RevenueFromContractWithCustomerExcludingAssessedTax",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuebySourceDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_RevenueFromContractWithCustomerPolicyTextBlock": {
     "auth_ref": [
      "r125",
      "r262"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for revenue from contract with customer.",
        "label": "Revenue from Contract with Customer [Policy Text Block]",
        "verboseLabel": "Revenue Recognition"
       }
      }
     },
     "localname": "RevenueFromContractWithCustomerPolicyTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_RevenuesAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Revenues [Abstract]",
        "verboseLabel": "Revenues:"
       }
      }
     },
     "localname": "RevenuesAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_RoyaltyAgreementsMember": {
     "auth_ref": [
      "r364"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contractual arrangement, generally for a defined period of time, entitling the entity to use the rights and property of another party. Examples include, but not limited to, licensing the use of copyrighted materials and leasing the extraction of natural resources.",
        "label": "Royalty Agreements [Member]",
        "terseLabel": "Royalty Agreements"
       }
      }
     },
     "localname": "RoyaltyAgreementsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_RoyaltyMember": {
     "auth_ref": [
      "r256"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Money for usage-based right to asset.",
        "label": "Royalty [Member]",
        "terseLabel": "Royalties"
       }
      }
     },
     "localname": "RoyaltyMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_SalesRevenueNetMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Revenue from sale of goods and services rendered, in the normal course of business, after sales returns and allowances, and sales discounts, when it serves as a benchmark in a concentration of risk calculation.",
        "label": "Sales Revenue, Net [Member]",
        "terseLabel": "Revenue"
       }
      }
     },
     "localname": "SalesRevenueNetMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the components of accrued liabilities.",
        "label": "Schedule of Accrued Liabilities [Table Text Block]",
        "terseLabel": "Schedule of Accrued Liabilities"
       }
      }
     },
     "localname": "ScheduleOfAccruedLiabilitiesTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfAvailableForSaleSecuritiesLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Debt Securities, Available-for-sale [Line Items]",
        "terseLabel": "Debt Securities, Available-for-sale [Line Items]"
       }
      }
     },
     "localname": "ScheduleOfAvailableForSaleSecuritiesLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable": {
     "auth_ref": [
      "r357",
      "r358"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule reflecting each material business combination (or series of individually immaterial business combinations) completed during the period, including background, timing, and recognized assets and liabilities.",
        "label": "Schedule of Business Acquisitions, by Acquisition [Table]",
        "terseLabel": "Schedule of Business Acquisitions, by Acquisition [Table]"
       }
      }
     },
     "localname": "ScheduleOfBusinessAcquisitionsByAcquisitionTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsContingentLiabilitiesDetails",
      "http://www.ligand.com/role/BusinessCombinationsAssetsAcquiredandLiabilitiesAssumedDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails",
      "http://www.ligand.com/role/BusinessCombinationsNarrativeDetails",
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock": {
     "auth_ref": [
      "r349"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the components of income tax expense attributable to continuing operations for each year presented including, but not limited to: current tax expense (benefit), deferred tax expense (benefit), investment tax credits, government grants, the benefits of operating loss carryforwards, tax expense that results from allocating certain tax benefits either directly to contributed capital or to reduce goodwill or other noncurrent intangible assets of an acquired entity, adjustments of a deferred tax liability or asset for enacted changes in tax laws or rates or a change in the tax status of the entity, and adjustments of the beginning-of-the-year balances of a valuation allowance because of a change in circumstances that causes a change in judgment about the realizability of the related deferred tax asset in future years.",
        "label": "Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]",
        "terseLabel": "Schedule of Components of Income Tax Benefit"
       }
      }
     },
     "localname": "ScheduleOfComponentsOfIncomeTaxExpenseBenefitTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfDebtTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of information pertaining to short-term and long-debt instruments or arrangements, including but not limited to identification of terms, features, collateral requirements and other information necessary to a fair presentation.",
        "label": "Schedule of Debt [Table Text Block]",
        "terseLabel": "Schedule of Equity and Liability Components of the Convertible Senior Notes"
       }
      }
     },
     "localname": "ScheduleOfDebtTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/ConvertibleSeniorNotesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock": {
     "auth_ref": [
      "r341"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.",
        "label": "Schedule of Deferred Tax Assets and Liabilities [Table Text Block]",
        "terseLabel": "Schedule of Deferred Tax Assets and Liabilities"
       }
      }
     },
     "localname": "ScheduleOfDeferredTaxAssetsAndLiabilitiesTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfDerivativeInstrumentsTextBlock": {
     "auth_ref": [
      "r135",
      "r394",
      "r395",
      "r396",
      "r397",
      "r398",
      "r403",
      "r404",
      "r406",
      "r407"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of pertinent information about a derivative or group of derivatives on a disaggregated basis, such as for individual instruments, or small groups of similar instruments. May include a combination of the type of instrument, risks being hedged, notional amount, hedge designation, related hedged item, inception date, maturity date, or other relevant item.",
        "label": "Schedule of Derivative Instruments [Table Text Block]",
        "terseLabel": "Schedule of Inputs and Assumptions Used to Calculate Fair Value of Derivatives"
       }
      }
     },
     "localname": "ScheduleOfDerivativeInstrumentsTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock": {
     "auth_ref": [
      "r150"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of an entity's basic and diluted earnings per share calculations, including a reconciliation of numerators and denominators of the basic and diluted per-share computations for income from continuing operations.",
        "label": "Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]",
        "verboseLabel": "Schedule of Computation of Basic and Diluted Net Income (Loss) per Share"
       }
      }
     },
     "localname": "ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock": {
     "auth_ref": [
      "r327"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.",
        "label": "Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]",
        "terseLabel": "Schedule of Effective Income Tax Rate Reconciliation"
       }
      }
     },
     "localname": "ScheduleOfEffectiveIncomeTaxRateReconciliationTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable": {
     "auth_ref": [
      "r180"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure about the extent of the entity's reliance on its major customers.",
        "label": "Schedule of Revenue by Major Customers, by Reporting Segments [Table]",
        "terseLabel": "Schedule of Revenue by Major Customers, by Reporting Segments [Table]"
       }
      }
     },
     "localname": "ScheduleOfEntityWideRevenueByMajorCustomersByReportingSegmentsTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesRevenuefromSignificantPartnersDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfFiniteLivedIntangibleAssetsTable": {
     "auth_ref": [
      "r206",
      "r210"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule of assets, excluding financial assets and goodwill, lacking physical substance with a finite life.",
        "label": "Schedule of Finite-Lived Intangible Assets [Table]",
        "terseLabel": "Schedule of Finite-Lived Intangible Assets [Table]"
       }
      }
     },
     "localname": "ScheduleOfFiniteLivedIntangibleAssetsTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails",
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCommercialLicenseRightsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock": {
     "auth_ref": [
      "r203"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of goodwill and intangible assets, which may be broken down by segment or major class.",
        "label": "Schedule of Intangible Assets and Goodwill [Table Text Block]",
        "verboseLabel": "Schedule of Goodwill and Other Identifiable Intangible Assets"
       }
      }
     },
     "localname": "ScheduleOfIntangibleAssetsAndGoodwillTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock": {
     "auth_ref": [
      "r283"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the changes in outstanding nonvested restricted stock units.",
        "label": "Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]",
        "verboseLabel": "Schedule of Restricted Stock Activity"
       }
      }
     },
     "localname": "ScheduleOfNonvestedRestrictedStockUnitsActivityTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfOperatingLeasedAssetsTable": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule of long-lived, depreciable assets that are subject to a operating lease agreements and are used in the normal conduct of business to produce goods and services. Examples may include land, buildings, machinery and equipment, and other types of furniture and equipment including, but not limited to, office equipment, furniture and fixtures, and computer equipment and software.",
        "label": "Schedule of Operating Leased Assets [Table]",
        "terseLabel": "Schedule of Operating Leased Assets [Table]"
       }
      }
     },
     "localname": "ScheduleOfOperatingLeasedAssetsTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsOperatingLeaseObligationsandPaymentsDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfOtherCurrentAssetsTableTextBlock": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the carrying amounts of other current assets.",
        "label": "Schedule of Other Current Assets [Table Text Block]",
        "terseLabel": "Schedule of Other Current Assets"
       }
      }
     },
     "localname": "ScheduleOfOtherCurrentAssetsTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfPropertyPlantAndEquipmentTable": {
     "auth_ref": [
      "r43",
      "r220"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of information about physical assets used in the normal conduct of business and not intended for resale. Includes, but is not limited to, balances by class of assets, depreciation and depletion expense and method used, including composite depreciation, and accumulated deprecation.",
        "label": "Property, Plant and Equipment [Table]",
        "verboseLabel": "Property, Plant and Equipment [Table]"
       }
      }
     },
     "localname": "ScheduleOfPropertyPlantAndEquipmentTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsPropertyandEquipmentDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock": {
     "auth_ref": [
      "r438"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of lessor's property under leasing agreements and property available for lease (not currently under lease) by property class, the gross amount, accumulated depreciation and net amount of  as of the balance sheet date.",
        "label": "Schedule of Property Subject to or Available for Operating Lease [Table Text Block]",
        "terseLabel": "Schedule of Operating Lease Obligations and Payments Expected to be Received from Sublease Agreements"
       }
      }
     },
     "localname": "ScheduleOfPropertySubjectToOrAvailableForOperatingLeaseTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/LeaseObligationsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfQuarterlyFinancialInformationTableTextBlock": {
     "auth_ref": [
      "r154"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of quarterly financial data. Includes, but is not limited to, financial information for fiscal quarters, cumulative effect of a change in accounting principle and earnings per share data.",
        "label": "Quarterly Financial Information [Table Text Block]",
        "terseLabel": "Schedule of Quarterly Financial Information"
       }
      }
     },
     "localname": "ScheduleOfQuarterlyFinancialInformationTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock": {
     "auth_ref": [
      "r361"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the amounts recognized as of the acquisition date for each major class of assets acquired and liabilities assumed. May include but not limited to the following: (a) acquired receivables; (b) contingencies recognized at the acquisition date; and (c) the fair value of noncontrolling interests in the acquiree.",
        "label": "Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]",
        "terseLabel": "Schedule of Recognized Identified Assets Acquired and Liabilities Assumed"
       }
      }
     },
     "localname": "ScheduleOfRecognizedIdentifiedAssetsAcquiredAndLiabilitiesAssumedTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BusinessCombinationsTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable": {
     "auth_ref": [
      "r272",
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Components of an equity-based arrangement under which compensation is awarded to employees, typically comprised of compensation expense; changes in the quantity and fair value of the shares (or other type of equity) granted, exercised, forfeited, and issued and outstanding pertaining to that plan; and cash flow effects resulting from the equity-based payment arrangement. Component disclosures are by type of award and plan name.",
        "label": "Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]",
        "terseLabel": "Schedule of Share-based Compensation Arrangements by Share-based Payment Award [Table]"
       }
      }
     },
     "localname": "ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails",
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails",
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of option exercise prices, by grouped ranges, including the upper and lower limits of the price range, the number of shares under option, weighted average exercise price and remaining contractual option terms.",
        "label": "Schedule of Share-based Compensation, Shares Authorized under Stock Option Plans, by Exercise Price Range [Table Text Block]",
        "terseLabel": "Schedule of Stock Option Plan Activity by Exercise Price Range"
       }
      }
     },
     "localname": "ScheduleOfShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock": {
     "auth_ref": [
      "r277",
      "r289",
      "r292"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.",
        "label": "Share-based Compensation, Stock Options, Activity [Table Text Block]",
        "verboseLabel": "Schedule of Stock Option Plan Activity"
       }
      }
     },
     "localname": "ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock": {
     "auth_ref": [
      "r295"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.",
        "label": "Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]",
        "terseLabel": "Schedule of Stock Option Weighted-Average Assumptions"
       }
      }
     },
     "localname": "ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock": {
     "auth_ref": [
      "r334"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the change in unrecognized tax benefits, excluding amounts pertaining to examined tax returns.",
        "label": "Schedule of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns Roll Forward [Table Text Block]",
        "terseLabel": "Schedule of Unrecognized Tax Benefits"
       }
      }
     },
     "localname": "ScheduleOfUnrecognizedTaxBenefitsExcludingAmountsPertainingToExaminedTaxReturnsRollForwardTableTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ScheduleOfVariableInterestEntitiesTable": {
     "auth_ref": [
      "r381",
      "r382",
      "r384",
      "r385",
      "r386"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of qualitative and quantitative information related to variable interests the entity holds, whether or not such variable interest entity (VIE) is included in the reporting entity's consolidated financial statements. Includes, but is not limited to, description of the significant judgments and assumptions made in determining whether a variable interest (as defined) held by the entity requires the variable interest entity (VIE) (as defined) to be consolidated and (or) disclose information about its involvement with the VIE, individually or in aggregate (as applicable); the nature of restrictions, if any, on the consolidated VIE's assets and on the settlement of its liabilities reported by an entity in its statement of financial position, including the carrying amounts of such assets and liabilities; the nature of, and changes in, the risks associated with involvement in the VIE; how involvement with the VIE affects the entity's financial position, financial performance, and cash flows; the lack of recourse if creditors (or beneficial interest holders) of the consolidated VIE have no recourse to the general credit of the primary beneficiary (if applicable); the terms of arrangements, giving consideration to both explicit arrangements and implicit variable interests, if any, that could require the entity to provide financial support to the VIE, including events or circumstances that could expose the entity to a loss; the methodology used by the entity for determining whether or not it is the primary beneficiary of the variable interest entity; the significant factors considered and judgments made in determining that the power to direct the activities of a VIE that most significantly impact the VIE's economic performance are shared (as defined); the carrying amounts and classification of assets and liabilities of the VIE included in the statement of financial position; the entity's maximum exposure to loss, if any, as a result of its involvement with the VIE, including how the maximum exposure is determined and significant sources of the entity's exposure to the VIE; a tabular comparison of the carrying amounts of the assets and liabilities and the entity's maximum exposure to loss; information about any liquidity arrangements, guarantees, and (or) other commitments by third parties that may affect the fair value or risk of the entity's variable interest in the VIE; whether or not the entity has provided financial support or other support (explicitly or implicitly) to the VIE that it was not previously contractually required to provide or whether the entity intends to provide that support, including the type and amount of the support and the primary reasons for providing the support; and supplemental information the entity determines necessary to provide.",
        "label": "Schedule of Variable Interest Entities [Table]",
        "terseLabel": "Schedule of Variable Interest Entities [Table]"
       }
      }
     },
     "localname": "ScheduleOfVariableInterestEntitiesTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_SchedulesOfConcentrationOfRiskByRiskFactorTextBlock": {
     "auth_ref": [
      "r162",
      "r164",
      "r165",
      "r166",
      "r421",
      "r423"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Tabular disclosure of the nature of a concentration, a benchmark to which it is compared, and the percentage that the risk is to the benchmark.",
        "label": "Schedules of Concentration of Risk, by Risk Factor [Table Text Block]",
        "terseLabel": "Schedule of Major Customers"
       }
      }
     },
     "localname": "SchedulesOfConcentrationOfRiskByRiskFactorTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesTables"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_SeniorNotesMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Bond that takes priority over other debt securities sold by the issuer. In the event the issuer goes bankrupt, senior debt holders receive priority for (must receive) repayment prior to (relative to) junior and unsecured (general) creditors.",
        "label": "Senior Notes [Member]",
        "terseLabel": "Senior Notes"
       }
      }
     },
     "localname": "SeniorNotesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/FairValueMeasurementReconciliationofLevel3FinancialInstrumentsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ShareBasedCompensation": {
     "auth_ref": [
      "r114"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS": {
       "order": 9.0,
       "parentTag": "us-gaap_NetCashProvidedByUsedInOperatingActivities",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.",
        "label": "Share-based Compensation",
        "verboseLabel": "Stock-based compensation"
       }
      }
     },
     "localname": "ShareBasedCompensation",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ShareBasedCompensationAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Share-based Compensation [Abstract]",
        "terseLabel": "Share-based Compensation"
       }
      }
     },
     "localname": "ShareBasedCompensationAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1": {
     "auth_ref": [
      "r273"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period which an employee's right to exercise an award is no longer contingent on satisfaction of either a service condition, market condition or a performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period",
        "terseLabel": "Award vesting period"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod": {
     "auth_ref": [
      "r282"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeited in Period",
        "negatedLabel": "Forfeited (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue": {
     "auth_ref": [
      "r287"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average fair value as of the grant date of equity-based award plans other than stock (unit) option plans that were not exercised or put into effect as a result of the occurrence of a terminating event.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value",
        "verboseLabel": "Forfeited (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod": {
     "auth_ref": [
      "r285"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period",
        "verboseLabel": "Granted (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue": {
     "auth_ref": [
      "r285"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value",
        "terseLabel": "Granted (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber": {
     "auth_ref": [
      "r284"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number",
        "periodEndLabel": "Outstanding at end of period (shares)",
        "periodStartLabel": "Outstanding at beginning of period (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]",
        "verboseLabel": "Shares [Rollforward]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue": {
     "auth_ref": [
      "r284"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted average fair value of nonvested awards on equity-based plans excluding option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, revenue or profit achievement stock award plan) for which the employer is contingently obligated to issue equity instruments or transfer assets to an employee who has not yet satisfied service or performance criteria necessary to gain title to proceeds from the sale of the award or underlying shares or units.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value",
        "periodEndLabel": "Outstanding at end of period (USD per share)",
        "periodStartLabel": "Outstanding at beginning of period (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract]",
        "terseLabel": "Weighted-Average Grant Date Fair Value [Roll Forward]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValueRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod": {
     "auth_ref": [
      "r286"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of equity-based payment instruments, excluding stock (or unit) options, that vested during the reporting period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period",
        "negatedLabel": "Vested (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue": {
     "auth_ref": [
      "r286"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted average fair value as of grant date pertaining to an equity-based award plan other than a stock (or unit) option plan for which the grantee gained the right during the reporting period, by satisfying service and performance requirements, to receive or retain shares or units, other instruments, or cash in accordance with the terms of the arrangement.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value",
        "verboseLabel": "Vested (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate": {
     "auth_ref": [
      "r297"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The estimated measure of the percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate",
        "terseLabel": "Expected volatility (as a percent)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate": {
     "auth_ref": [
      "r298"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The risk-free interest rate assumption that is used in valuing an option on its own shares.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate",
        "verboseLabel": "Risk-free interest rate (as a percent)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award [Line Items]",
        "terseLabel": "Share-based Compensation Arrangement by Share-based Payment Award [Line Items]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails",
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails",
      "http://www.ligand.com/role/StockholdersEquityShareBasedCompensationDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The highest quantity of shares an employee can purchase under the plan per period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee",
        "verboseLabel": "Shares allowed to purchase in employee stock purchase plan per employee (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumNumberOfSharesPerEmployee",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of additional shares authorized for issuance under an established share-based compensation plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized",
        "terseLabel": "Increase the number of shares under the 2002 Stock Incentive Plan (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant",
        "verboseLabel": "Shares available for future option grants (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber": {
     "auth_ref": [
      "r280"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number",
        "verboseLabel": "Exercisable at end of period (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice": {
     "auth_ref": [
      "r280"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price",
        "verboseLabel": "Exercisable at end of period (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue": {
     "auth_ref": [
      "r291"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of accumulated difference between fair value of underlying shares on dates of exercise and exercise price on options exercised (or share units converted) into shares.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value",
        "verboseLabel": "Intrinsic value of options exercised"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisesInPeriodTotalIntrinsicValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod": {
     "auth_ref": [
      "r282"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Forfeitures in Period",
        "negatedLabel": "Forfeited (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Gross number of share options (or share units) granted during the period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross",
        "verboseLabel": "Granted (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue": {
     "auth_ref": [
      "r290"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value",
        "verboseLabel": "Weighted-average grant date fair value per share of stock options (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue": {
     "auth_ref": [
      "r301"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value",
        "verboseLabel": "Aggregate Intrinsic Value"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber": {
     "auth_ref": [
      "r279",
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of options outstanding, including both vested and non-vested options.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number",
        "periodEndLabel": "Balance at end of period (shares)",
        "periodStartLabel": "Balance at beginning of period (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]",
        "verboseLabel": "Shares [Rollforward]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice": {
     "auth_ref": [
      "r278"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price",
        "periodEndLabel": "Balance at end of period (USD per share)",
        "periodStartLabel": "Balance at beginning of period (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract]",
        "terseLabel": "Weighted Average Exercise Price [Roll Forward]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue": {
     "auth_ref": [
      "r292"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount by which current fair value of underlying stock exceeds exercise price of fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value",
        "verboseLabel": "Options vested and expected to vest, Aggregate Intrinsic Value"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber": {
     "auth_ref": [
      "r293"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of fully vested and expected to vest options outstanding that can be converted into shares under option plan. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number",
        "verboseLabel": "Options vested and expected to vest at end of period (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice": {
     "auth_ref": [
      "r293"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted-average exercise price, at which grantee can acquire shares reserved for issuance, for fully vested and expected to vest options outstanding. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price",
        "verboseLabel": "Options vested and expected to vest at end of period (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of share instruments newly issued under a share-based compensation plan.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period",
        "verboseLabel": "Common stock issued under amended ESSP (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementByShareBasedPaymentAwardSharesIssuedInPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain": {
     "auth_ref": [
      "r269",
      "r275"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Equity-based compensation award.",
        "label": "Equity Award [Domain]",
        "terseLabel": "Award Type [Domain]"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails",
      "http://www.ligand.com/role/StockholdersEquityRestrictedStockActivityDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average price at which option holders acquired shares when converting their stock options into shares.",
        "label": "Share-based Compensation Arrangements by Share-based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price",
        "verboseLabel": "Exercised (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.",
        "label": "Share-based Compensation Arrangements by Share-based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price",
        "verboseLabel": "Forfeited (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.",
        "label": "Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price",
        "verboseLabel": "Granted (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy": {
     "auth_ref": [
      "r124",
      "r272",
      "r276"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for stock option and stock incentive plans. This disclosure may include (1) the types of stock option or incentive plans sponsored by the entity (2) the groups that participate in (or are covered by) each plan (3) significant plan provisions and (4) how stock compensation is measured, and the methodologies and significant assumptions used to determine that measurement.",
        "label": "Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]",
        "verboseLabel": "Share-Based Compensation"
       }
      }
     },
     "localname": "ShareBasedCompensationOptionAndIncentivePlansPolicy",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis": {
     "auth_ref": [
      "r294"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by range of option prices pertaining to options granted.",
        "label": "Exercise Price Range [Axis]",
        "terseLabel": "Exercise Price Range [Axis]"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansByExercisePriceRangeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain": {
     "auth_ref": [
      "r299"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Supplementary information on outstanding and exercisable share awards as of the balance sheet date which stratifies outstanding options by ranges of exercise prices.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain]",
        "terseLabel": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Domain]"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit": {
     "auth_ref": [
      "r299"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The floor of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Lower Range Limit",
        "terseLabel": "Lower range of exercise prices (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeLowerRangeLimit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions": {
     "auth_ref": [
      "r288"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of shares reserved for issuance pertaining to the outstanding exercisable stock options as of the balance sheet date in the customized range of exercise prices for which the market and performance vesting condition has been satisfied.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Exercisable Options",
        "terseLabel": "Options exercisable (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfExercisableOptions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions": {
     "auth_ref": [
      "r279"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The number of shares reserved for issuance pertaining to the outstanding stock options as of the balance sheet date for all option plans in the customized range of exercise prices.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Number of Outstanding Options",
        "terseLabel": "Options outstanding (shares)"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeNumberOfOutstandingOptions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit": {
     "auth_ref": [
      "r299"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The ceiling of a customized range of exercise prices for purposes of disclosing shares potentially issuable under outstanding stock option awards on all stock option plans and other required information pertaining to awards in the customized range.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Upper Range Limit",
        "terseLabel": "Upper range of exercise prices (USD per share)"
       }
      }
     },
     "localname": "ShareBasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeUpperRangeLimit",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_SharePrice": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Price of a single share of a number of saleable stocks of a company.",
        "label": "Share Price",
        "terseLabel": "Common stock price (USD per share)",
        "verboseLabel": "Common stock price (USD per share)"
       }
      }
     },
     "localname": "SharePrice",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesDerivativesDetails",
      "http://www.ligand.com/role/BusinessCombinationsConsiderationTransferredDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage": {
     "auth_ref": [
      "r273"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Percentage of vesting of share-based compensation awards.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage",
        "terseLabel": "Award vesting right (as a percent)"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardAwardVestingRightsPercentage",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "percentItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod": {
     "auth_ref": [
      "r274"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period",
        "terseLabel": "Award expiration period"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1": {
     "auth_ref": [
      "r296",
      "r313"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Expected term of share-based compensation awards, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term",
        "terseLabel": "Expected term"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityAssumptionsDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1": {
     "auth_ref": [
      "r301"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value",
        "verboseLabel": "Exercisable, Aggregate Intrinsic Value"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term",
        "verboseLabel": "Exercisable, Weighted Average Remaining Contractual Term in Years"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2": {
     "auth_ref": [
      "r293"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term",
        "verboseLabel": "Weighted Average Remaining Contractual Term in Years"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1": {
     "auth_ref": [
      "r293"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average remaining contractual term for fully vested and expected to vest options outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, unvested options for which requisite service period has not been rendered but that are expected to vest based on achievement of performance condition, if forfeitures are recognized when they occur.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term",
        "verboseLabel": "Options vested and expected to vest, Weighted Average Remaining Contractual Term in Years"
       }
      }
     },
     "localname": "SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1": {
     "auth_ref": [
      "r280"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average exercise price as of the balance sheet date for those equity-based payment arrangements exercisable and outstanding.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Exercisable Options, Weighted Average Exercise Price",
        "terseLabel": "Weighted average exercise price (USD per share)"
       }
      }
     },
     "localname": "SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeExercisableOptionsWeightedAverageExercisePrice1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1": {
     "auth_ref": [
      "r279"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The weighted average price as of the balance sheet date at which grantees could acquire the underlying shares with respect to all outstanding stock options which are in the customized range of exercise prices.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Exercise Price",
        "terseLabel": "Weighted average exercise price (USD per share)"
       }
      }
     },
     "localname": "SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageExercisePriceBeginningBalance1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "perShareItemType"
    },
    "us-gaap_SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2": {
     "auth_ref": [
      "r293"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Weighted average remaining contractual term of outstanding stock options, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Outstanding Options, Weighted Average Remaining Contractual Term",
        "terseLabel": "Weighted average remaining life in years"
       }
      }
     },
     "localname": "SharebasedCompensationSharesAuthorizedUnderStockOptionPlansExercisePriceRangeOutstandingOptionsWeightedAverageRemainingContractualTerm2",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityBreakdownofOptionsOutstandingDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_SharesOutstanding": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares issued which are neither cancelled nor held in the treasury.",
        "label": "Shares, Outstanding",
        "periodEndLabel": "Balance at end of period (shares)",
        "periodStartLabel": "Balance at beginning of period (shares)"
       }
      }
     },
     "localname": "SharesOutstanding",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_ShortTermInvestments": {
     "auth_ref": [
      "r24",
      "r470",
      "r471",
      "r473",
      "r488"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 2.0,
       "parentTag": "us-gaap_AssetsCurrent",
       "weight": 1.0
      }
     },
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of investments including trading securities, available-for-sale securities, held-to-maturity securities, and short-term investments classified as other and current.",
        "label": "Short-term Investments",
        "terseLabel": "Short-term investments"
       }
      }
     },
     "localname": "ShortTermInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_ShortTermInvestmentsMember": {
     "auth_ref": [
      "r470",
      "r471",
      "r488",
      "r504"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Investments which are not otherwise included in another category or item that the entity has the intent to sell or dispose of within one year from the date of the balance sheet.",
        "label": "Short-term Investments [Member]",
        "terseLabel": "Short-term investments",
        "verboseLabel": "Short-term investments"
       }
      }
     },
     "localname": "ShortTermInvestmentsMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails",
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_StateAndLocalJurisdictionMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Designated tax department of a state or local government entitled to levy and collect income taxes from the entity.",
        "label": "State and Local Jurisdiction [Member]",
        "terseLabel": "State and Local Jurisdiction"
       }
      }
     },
     "localname": "StateAndLocalJurisdictionMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_StatementEquityComponentsAxis": {
     "auth_ref": [
      "r55",
      "r239"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by component of equity.",
        "label": "Equity Components [Axis]",
        "terseLabel": "Equity Components [Axis]"
       }
      }
     },
     "localname": "StatementEquityComponentsAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Statement [Line Items]",
        "terseLabel": "Statement [Line Items]"
       }
      }
     },
     "localname": "StatementLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementOfCashFlowsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Statement of Cash Flows [Abstract]"
       }
      }
     },
     "localname": "StatementOfCashFlowsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementOfFinancialPositionAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Statement of Financial Position [Abstract]",
        "terseLabel": "Condensed Balance Sheet:"
       }
      }
     },
     "localname": "StatementOfFinancialPositionAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Statement of Comprehensive Income [Abstract]"
       }
      }
     },
     "localname": "StatementOfIncomeAndComprehensiveIncomeAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementOfStockholdersEquityAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Statement of Stockholders' Equity [Abstract]"
       }
      }
     },
     "localname": "StatementOfStockholdersEquityAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "xbrltype": "stringItemType"
    },
    "us-gaap_StatementTable": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Schedule reflecting a Statement of Income, Statement of Cash Flows, Statement of Financial Position, Statement of Shareholders' Equity and Other Comprehensive Income, or other statement as needed.",
        "label": "Statement [Table]",
        "terseLabel": "Statement [Table]"
       }
      }
     },
     "localname": "StatementTable",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_StockIssuedDuringPeriodSharesAcquisitions": {
     "auth_ref": [
      "r30",
      "r31",
      "r245"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares of stock issued during the period pursuant to acquisitions.",
        "label": "Stock Issued During Period, Shares, Acquisitions",
        "terseLabel": "Shares issued in OMT acquisition (shares)"
       }
      }
     },
     "localname": "StockIssuedDuringPeriodSharesAcquisitions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans": {
     "auth_ref": [
      "r30",
      "r31",
      "r239",
      "r245"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares issued during the period as a result of an employee stock purchase plan.",
        "label": "Stock Issued During Period, Shares, Employee Stock Purchase Plans",
        "terseLabel": "Issuance of common stock under employee stock compensation plans, net (shares)"
       }
      }
     },
     "localname": "StockIssuedDuringPeriodSharesEmployeeStockPurchasePlans",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised": {
     "auth_ref": [
      "r30",
      "r31",
      "r239",
      "r245",
      "r281"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of share options (or share units) exercised during the current period.",
        "label": "Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period",
        "negatedLabel": "Exercised (shares)"
       }
      }
     },
     "localname": "StockIssuedDuringPeriodSharesStockOptionsExercised",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityStockOptionPlanActivityDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_StockIssuedDuringPeriodValueAcquisitions": {
     "auth_ref": [
      "r55",
      "r239",
      "r245"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of stock issued pursuant to acquisitions during the period.",
        "label": "Stock Issued During Period, Value, Acquisitions",
        "negatedLabel": "Stock issued for acquisition, net of issuance cost",
        "terseLabel": "Shares issued in OMT acquisition"
       }
      }
     },
     "localname": "StockIssuedDuringPeriodValueAcquisitions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockIssuedDuringPeriodValueShareBasedCompensation": {
     "auth_ref": [
      "r30",
      "r31",
      "r245",
      "r271",
      "r290"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of stock (or other type of equity) issued during the period as a result of any equity-based compensation plan other than an employee stock ownership plan (ESOP), net of stock value of such awards forfeited. Stock issued could result from the issuance of restricted stock, the exercise of stock options, stock issued under employee stock purchase plans, and/or other employee benefit plans.",
        "label": "Stock Issued During Period, Value, Share-based Compensation, Net of Forfeitures",
        "terseLabel": "Issuance of common stock under employee stock compensation plans, net"
       }
      }
     },
     "localname": "StockIssuedDuringPeriodValueShareBasedCompensation",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockRepurchaseProgramAuthorizedAmount1": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of stock repurchase plan authorized.",
        "label": "Stock Repurchase Program, Authorized Amount",
        "terseLabel": "Stock repurchase program, authorized amount"
       }
      }
     },
     "localname": "StockRepurchaseProgramAuthorizedAmount1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockRepurchaseProgramPeriodInForce1": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Period which shares may be purchased under a stock repurchase plan authorized by an entity's Board of Directors, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.",
        "label": "Stock Repurchase Program, Period in Force",
        "terseLabel": "Stock repurchase program, period in force"
       }
      }
     },
     "localname": "StockRepurchaseProgramPeriodInForce1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "durationItemType"
    },
    "us-gaap_StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1": {
     "auth_ref": [],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount remaining of a stock repurchase plan authorized.",
        "label": "Stock Repurchase Program, Remaining Authorized Repurchase Amount",
        "terseLabel": "Stock repurchase program, remaining authorized repurchase amount"
       }
      }
     },
     "localname": "StockRepurchaseProgramRemainingAuthorizedRepurchaseAmount1",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockRepurchasedDuringPeriodShares": {
     "auth_ref": [
      "r30",
      "r31",
      "r239",
      "r245"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares that have been repurchased during the period and have not been retired and are not held in treasury. Some state laws may govern the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.",
        "label": "Stock Repurchased During Period, Shares",
        "negatedTerseLabel": "Repurchase of common stock (shares)",
        "terseLabel": "Shares repurchased in period (shares)"
       }
      }
     },
     "localname": "StockRepurchasedDuringPeriodShares",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_StockRepurchasedDuringPeriodValue": {
     "auth_ref": [
      "r30",
      "r31",
      "r239",
      "r245"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Equity impact of the value of stock that has been repurchased during the period and has not been retired and is not held in treasury. Some state laws may mandate the circumstances under which an entity may acquire its own stock and prescribe the accounting treatment therefore. This element is used when state law does not recognize treasury stock.",
        "label": "Stock Repurchased During Period, Value",
        "negatedTerseLabel": "Repurchase of common stock",
        "terseLabel": "Shares repurchased in period"
       }
      }
     },
     "localname": "StockRepurchasedDuringPeriodValue",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY",
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockholdersEquity": {
     "auth_ref": [
      "r31",
      "r35",
      "r36",
      "r182"
     ],
     "calculation": {
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS": {
       "order": 4.0,
       "parentTag": "us-gaap_LiabilitiesAndStockholdersEquity",
       "weight": 1.0
      }
     },
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Total of all stockholders' equity (deficit) items, net of receivables from officers, directors, owners, and affiliates of the entity which are attributable to the parent. The amount of the economic entity's stockholders' equity attributable to the parent excludes the amount of stockholders' equity which is allocable to that ownership interest in subsidiary equity which is not attributable to the parent (noncontrolling interest, minority interest). This excludes temporary equity and is sometimes called permanent equity.",
        "label": "Stockholders' Equity Attributable to Parent",
        "totalLabel": "Total stockholders\u2019 equity"
       }
      }
     },
     "localname": "StockholdersEquity",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockholdersEquityAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Stockholders' Equity Attributable to Parent [Abstract]",
        "verboseLabel": "Stockholders\u2019 equity:"
       }
      }
     },
     "localname": "StockholdersEquityAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDBALANCESHEETS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest": {
     "auth_ref": [
      "r373",
      "r374",
      "r387"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of stockholders' equity (deficit), net of receivables from officers, directors, owners, and affiliates of the entity, attributable to both the parent and noncontrolling interests. Amount excludes temporary equity. Alternate caption for the concept is permanent equity.",
        "label": "Stockholders' Equity, Including Portion Attributable to Noncontrolling Interest",
        "periodEndLabel": "Balance at end of period",
        "periodStartLabel": "Balance at beginning of period"
       }
      }
     },
     "localname": "StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_StockholdersEquityNoteDisclosureTextBlock": {
     "auth_ref": [
      "r247"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.",
        "label": "Stockholders' Equity Note Disclosure [Text Block]",
        "verboseLabel": "Stockholders' Equity"
       }
      }
     },
     "localname": "StockholdersEquityNoteDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquity"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_SubsequentEventMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Identifies event that occurred after the balance sheet date but before financial statements are issued or available to be issued.",
        "label": "Subsequent Event [Member]",
        "terseLabel": "Subsequent Event"
       }
      }
     },
     "localname": "SubsequentEventMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_SubsequentEventTypeAxis": {
     "auth_ref": [
      "r445"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by event that occurred after the balance sheet date but before financial statements are issued or available to be issued.",
        "label": "Subsequent Event Type [Axis]",
        "terseLabel": "Subsequent Event Type [Axis]"
       }
      }
     },
     "localname": "SubsequentEventTypeAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_SubsequentEventTypeDomain": {
     "auth_ref": [
      "r445"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Event that occurred after the balance sheet date but before financial statements are issued or available to be issued.",
        "label": "Subsequent Event Type [Domain]",
        "terseLabel": "Subsequent Event Type [Domain]"
       }
      }
     },
     "localname": "SubsequentEventTypeDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/StockholdersEquityNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_SupplementalBalanceSheetDisclosuresTextBlock": {
     "auth_ref": [
      "r63"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for supplemental balance sheet disclosures, including descriptions and amounts for assets, liabilities, and equity.",
        "label": "Supplemental Balance Sheet Disclosures [Text Block]",
        "terseLabel": "Balance Sheet Account Details"
       }
      }
     },
     "localname": "SupplementalBalanceSheetDisclosuresTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetails"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_SupplementalCashFlowInformationAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Supplemental Cash Flow Information [Abstract]",
        "verboseLabel": "Supplemental disclosure of cash flow information"
       }
      }
     },
     "localname": "SupplementalCashFlowInformationAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_TaxCreditCarryforwardAmount": {
     "auth_ref": [
      "r343"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.",
        "label": "Tax Credit Carryforward, Amount",
        "terseLabel": "Tax credit carryforward"
       }
      }
     },
     "localname": "TaxCreditCarryforwardAmount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_TaxCreditCarryforwardAxis": {
     "auth_ref": [
      "r344"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by specific tax credit related to an unused tax credit.",
        "label": "Tax Credit Carryforward [Axis]",
        "terseLabel": "Tax Credit Carryforward [Axis]"
       }
      }
     },
     "localname": "TaxCreditCarryforwardAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_TaxCreditCarryforwardNameDomain": {
     "auth_ref": [
      "r344"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The name of the tax credit carryforward.",
        "label": "Tax Credit Carryforward, Name [Domain]",
        "terseLabel": "Tax Credit Carryforward, Name [Domain]"
       }
      }
     },
     "localname": "TaxCreditCarryforwardNameDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TimingOfTransferOfGoodOrServiceAxis": {
     "auth_ref": [
      "r253",
      "r259"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by timing of transfer of good or service to customer.",
        "label": "Timing of Transfer of Good or Service [Axis]",
        "terseLabel": "Timing of Transfer of Good or Service [Axis]"
       }
      }
     },
     "localname": "TimingOfTransferOfGoodOrServiceAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_TimingOfTransferOfGoodOrServiceDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Timing of transfer of good or service to customer. Includes, but is not limited to, at point in time or over time.",
        "label": "Timing of Transfer of Good or Service [Domain]",
        "terseLabel": "Timing of Transfer of Good or Service [Domain]"
       }
      }
     },
     "localname": "TimingOfTransferOfGoodOrServiceDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TitleOfIndividualAxis": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by title of individual or nature of relationship to individual or group of individuals.",
        "label": "Title of Individual [Axis]",
        "terseLabel": "Title of Individual [Axis]"
       }
      }
     },
     "localname": "TitleOfIndividualAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_TitleOfIndividualWithRelationshipToEntityDomain": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Title of individual, or nature of relationship to individual or group of individuals.",
        "label": "Relationship to Entity [Domain]",
        "terseLabel": "Relationship to Entity [Domain]"
       }
      }
     },
     "localname": "TitleOfIndividualWithRelationshipToEntityDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TradeNamesMember": {
     "auth_ref": [
      "r362"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Rights acquired through registration of a business name to gain or protect exclusive use thereof.",
        "label": "Trade Names [Member]",
        "verboseLabel": "Trade name"
       }
      }
     },
     "localname": "TradeNamesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsGoodwillandOtherIntangibleAssetsDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TransferredOverTimeMember": {
     "auth_ref": [
      "r253",
      "r259"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Contract with customer in which good or service is transferred over time.",
        "label": "Transferred over Time [Member]",
        "terseLabel": "Transferred over Time"
       }
      }
     },
     "localname": "TransferredOverTimeMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain": {
     "auth_ref": [
      "r450"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Instrument or contract that imposes a contractual obligation to deliver cash or another financial instrument or to exchange other financial instruments on potentially unfavorable terms and conveys a contractual right to receive cash or another financial instrument or to exchange other financial instruments on potentially favorable terms.",
        "label": "Financial Instruments [Domain]",
        "terseLabel": "Financial Instruments [Domain]"
       }
      }
     },
     "localname": "TransfersAndServicingOfFinancialInstrumentsTypesOfFinancialInstrumentsDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_TypeOfAdoptionMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Adoption and early adoption of sources of change to generally accepted accounting principles (GAAP) in the United States. The FASB released the FASB Accounting Standards Codification as the authoritative source of literature effective for interim and annual periods ending after September 15, 2009. As part of the Codification process, the FASB issues Accounting Standards Updates to amend the Codification but otherwise the Accounting Standards Updates are not authoritative in their own right. All previous accounting standards (such as FASB Statements of Financial Accounting Standards, FASB Interpretations, FASB Staff Positions, Emerging Issues Task Force Consensuses, other pronouncements of the FASB or other designated bodies, or other forms of GAAP are considered accounting pronouncements) were superseded upon the adoption of the Codification. For an interim period, references to the superseded standards are included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy.",
        "label": "Type of Adoption [Domain]",
        "terseLabel": "Type of Adoption [Domain]"
       }
      }
     },
     "localname": "TypeOfAdoptionMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTOFSTOCKHOLDERSEQUITY"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_USGovernmentAgenciesDebtSecuritiesMember": {
     "auth_ref": [
      "r263",
      "r472"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Debentures, notes, and other debt securities issued by US government agencies, for example, but not limited to, Government National Mortgage Association (GNMA or Ginnie Mae). Excludes US treasury securities and debt issued by government-sponsored Enterprises (GSEs), for example, but is not limited to, Federal Home Loan Mortgage Corporation (FHLMC or Freddie Mac), Federal National Mortgage Association (FNMA or Fannie Mae), and the Federal Home Loan Bank (FHLB).",
        "label": "US Government Agencies Debt Securities [Member]",
        "terseLabel": "Agency bonds"
       }
      }
     },
     "localname": "USGovernmentAgenciesDebtSecuritiesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_USTreasurySecuritiesMember": {
     "auth_ref": [
      "r263",
      "r266",
      "r472"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "This category includes information about debt securities issued by the United States Department of the Treasury and backed by the United States government. Such securities primarily consist of treasury bills (short-term maturities - one year or less), treasury notes (intermediate term maturities - two to ten years), and treasury bonds (long-term maturities - ten to thirty years).",
        "label": "US Treasury Securities [Member]",
        "terseLabel": "U.S. Government bonds"
       }
      }
     },
     "localname": "USTreasurySecuritiesMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BalanceSheetAccountDetailsInvestmentCategoriesDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_UnrealizedGainLossOnInvestments": {
     "auth_ref": [
      "r115"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period.",
        "label": "Unrealized Gain (Loss) on Investments",
        "terseLabel": "Unrealized gain on AFS investments"
       }
      }
     },
     "localname": "UnrealizedGainLossOnInvestments",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWS"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UnrecognizedTaxBenefits": {
     "auth_ref": [
      "r320",
      "r330"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of unrecognized tax benefits.",
        "label": "Unrecognized Tax Benefits",
        "periodEndLabel": "Balance at end of period",
        "periodStartLabel": "Balance at beginning of period"
       }
      }
     },
     "localname": "UnrecognizedTaxBenefits",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions": {
     "auth_ref": [
      "r331"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of decrease in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.",
        "label": "Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions",
        "negatedTerseLabel": "Reductions for tax positions of prior years"
       }
      }
     },
     "localname": "UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions": {
     "auth_ref": [
      "r332"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase in unrecognized tax benefits resulting from tax positions that have been or will be taken in current period tax return.",
        "label": "Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions",
        "terseLabel": "Additions based on tax positions related to the current year"
       }
      }
     },
     "localname": "UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions": {
     "auth_ref": [
      "r331"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.",
        "label": "Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions",
        "terseLabel": "Additions for tax positions of prior years"
       }
      }
     },
     "localname": "UnrecognizedTaxBenefitsIncreasesResultingFromPriorPeriodTaxPositions",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesReconciliationofUnrecognizedTaxBenefitsDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate": {
     "auth_ref": [
      "r333"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The total amount of unrecognized tax benefits that, if recognized, would affect the effective tax rate.",
        "label": "Unrecognized Tax Benefits that Would Impact Effective Tax Rate",
        "terseLabel": "Unrecognized tax benefits that would impact effective tax rate"
       }
      }
     },
     "localname": "UnrecognizedTaxBenefitsThatWouldImpactEffectiveTaxRate",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_UseOfEstimates": {
     "auth_ref": [
      "r157",
      "r158",
      "r160",
      "r161",
      "r167",
      "r168",
      "r169"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Disclosure of accounting policy for the use of estimates in the preparation of financial statements in conformity with generally accepted accounting principles.",
        "label": "Use of Estimates, Policy [Policy Text Block]",
        "verboseLabel": "Use of Estimates"
       }
      }
     },
     "localname": "UseOfEstimates",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesPolicies"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount": {
     "auth_ref": [
      "r322"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Amount of increase (decrease) in the valuation allowance for a specified deferred tax asset.",
        "label": "Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount",
        "terseLabel": "Valuation allowance, change in amount"
       }
      }
     },
     "localname": "ValuationAllowanceDeferredTaxAssetChangeInAmount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/IncomeTaxesNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_VariableInterestEntitiesByClassificationOfEntityAxis": {
     "auth_ref": [
      "r381",
      "r382",
      "r385"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by category of Variable Interest Entity (VIE).",
        "label": "Variable Interest Entities [Axis]",
        "terseLabel": "Variable Interest Entities [Axis]"
       }
      }
     },
     "localname": "VariableInterestEntitiesByClassificationOfEntityAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_VariableInterestEntityDisclosureTextBlock": {
     "auth_ref": [
      "r393"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The entire disclosure for a variable interest entity (VIE), including but not limited to, judgments and assumptions in determining whether to consolidate and in identifying the primary beneficiary, gain (loss) recognized on the initial consolidation of the VIE, terms of arrangements, amounts and classification of the VIE's assets and liabilities, and the entity's maximum exposure to loss.",
        "label": "Variable Interest Entity Disclosure [Text Block]",
        "terseLabel": "Investment in Viking"
       }
      }
     },
     "localname": "VariableInterestEntityDisclosureTextBlock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinViking"
     ],
     "xbrltype": "textBlockItemType"
    },
    "us-gaap_VariableInterestEntityFinancialOrOtherSupportAmount": {
     "auth_ref": [
      "r383"
     ],
     "crdr": "debit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The amount of financial or other support the reporting entity has provided (explicitly or implicitly) to the Variable Interest Entity (VIE) that it was not previously contractually required to provide or that the reporting entity intends to provide, including, for example, situations in which the reporting entity assisted the VIE in obtaining another type of support.",
        "label": "Variable Interest Entity, Financial or Other Support, Amount",
        "terseLabel": "Convertible loan facility extended"
       }
      }
     },
     "localname": "VariableInterestEntityFinancialOrOtherSupportAmount",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_VariableInterestEntityLineItems": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.",
        "label": "Variable Interest Entity [Line Items]",
        "terseLabel": "Variable Interest Entity [Line Items]"
       }
      }
     },
     "localname": "VariableInterestEntityLineItems",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_VariableInterestEntityPrimaryBeneficiaryMember": {
     "auth_ref": [
      "r381"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Variable Interest Entities (VIE) in which the entity has a controlling financial interest (as defined) and of which it is therefore the primary beneficiary. A controlling financial interest is determined based on both: (a) the entity's power to direct activities of the VIE that most significantly impact the VIE's economic performance and (b) the entity's obligation to absorb losses of the VIE that could potentially be significant to the VIE or the right to receive benefits from the VIE that could potentially be significant to the VIE. VIEs of which the entity is the primary beneficiary are included in the consolidated financial statements of the entity.",
        "label": "Variable Interest Entity, Primary Beneficiary [Member]",
        "terseLabel": "Viking"
       }
      }
     },
     "localname": "VariableInterestEntityPrimaryBeneficiaryMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_VestingAxis": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Information by vesting schedule for share-based compensation.",
        "label": "Vesting [Axis]",
        "terseLabel": "Vesting [Axis]"
       }
      }
     },
     "localname": "VestingAxis",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_VestingDomain": {
     "auth_ref": [
      "r301"
     ],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Vesting schedule for share-based compensation.",
        "label": "Vesting [Domain]",
        "terseLabel": "Vesting [Domain]"
       }
      }
     },
     "localname": "VestingDomain",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_WarrantMember": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Security that gives the holder the right to purchase shares of stock in accordance with the terms of the instrument, usually upon payment of a specified amount.",
        "label": "Warrant [Member]",
        "terseLabel": "Investment in warrants",
        "verboseLabel": "Warrants"
       }
      }
     },
     "localname": "WarrantMember",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/FairValueMeasurementAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails",
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "domainItemType"
    },
    "us-gaap_WarrantsAndRightsOutstanding": {
     "auth_ref": [
      "r134"
     ],
     "crdr": "credit",
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Value of outstanding derivative securities that permit the holder the right to purchase securities (usually equity) from the issuer at a specified price.",
        "label": "Warrants and Rights Outstanding",
        "terseLabel": "Warrants"
       }
      }
     },
     "localname": "WarrantsAndRightsOutstanding",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/InvestmentinVikingNarrativeDetails"
     ],
     "xbrltype": "monetaryItemType"
    },
    "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding": {
     "auth_ref": [
      "r141",
      "r148"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": null,
       "parentTag": null,
       "root": true,
       "weight": null
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.",
        "label": "Weighted Average Number of Shares Outstanding, Diluted",
        "netLabel": "Diluted (shares)",
        "totalLabel": "Shares used to compute diluted income per share (shares)",
        "verboseLabel": "Weighted average shares\u2014diluted (shares)"
       }
      }
     },
     "localname": "WeightedAverageNumberOfDilutedSharesOutstanding",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_WeightedAverageNumberOfSharesOutstandingBasic": {
     "auth_ref": [
      "r139",
      "r148"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": 4.0,
       "parentTag": "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.",
        "label": "Weighted Average Number of Shares Outstanding, Basic",
        "netLabel": "Basic (shares)",
        "terseLabel": "Weighted-average common shares outstanding - basic (shares)",
        "verboseLabel": "Weighted average shares\u2014basic (shares)"
       }
      }
     },
     "localname": "WeightedAverageNumberOfSharesOutstandingBasic",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails",
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS",
      "http://www.ligand.com/role/SummaryofUnauditedQuarterlyFinancialInformationSummaryDetails"
     ],
     "xbrltype": "sharesItemType"
    },
    "us-gaap_WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract": {
     "auth_ref": [],
     "lang": {
      "en-US": {
       "role": {
        "label": "Weighted Average Number of Shares Outstanding Reconciliation [Abstract]",
        "terseLabel": "Weighted average common shares outstanding:"
       }
      }
     },
     "localname": "WeightedAverageNumberOfSharesOutstandingDilutedDisclosureItemsAbstract",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONS"
     ],
     "xbrltype": "stringItemType"
    },
    "us-gaap_WeightedAverageNumberOfSharesRestrictedStock": {
     "auth_ref": [
      "r140"
     ],
     "calculation": {
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails": {
       "order": 2.0,
       "parentTag": "us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding",
       "weight": 1.0
      }
     },
     "lang": {
      "en-US": {
       "role": {
        "documentation": "Number of shares of restricted stock determined by relating the portion of time within a reporting period that restricted shares have been outstanding to the total time in that period. Restricted shares are subject to sales, contractual, regulatory or other restrictions that prevent or inhibit the holder from freely disposing of them before the restriction ends.",
        "label": "Weighted Average Number of Shares, Restricted Stock",
        "verboseLabel": "Restricted stock (shares)"
       }
      }
     },
     "localname": "WeightedAverageNumberOfSharesRestrictedStock",
     "nsuri": "http://fasb.org/us-gaap/2018-01-31",
     "presentation": [
      "http://www.ligand.com/role/BasisofPresentationandSummaryofSignificantAccountingPoliciesCalculationofEarningsperShareDetails"
     ],
     "xbrltype": "sharesItemType"
    }
   },
   "unitCount": 8
  }
 },
 "std_ref": {
  "r0": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=6359566&loc=d3e326-107755"
  },
  "r1": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222160&loc=d3e957-107759"
  },
  "r10": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765"
  },
  "r100": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585"
  },
  "r101": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585"
  },
  "r102": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585"
  },
  "r103": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585"
  },
  "r104": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585"
  },
  "r105": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "17",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3367-108585"
  },
  "r106": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3000-108585"
  },
  "r107": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "24",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3521-108585"
  },
  "r108": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585"
  },
  "r109": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a),(c)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585"
  },
  "r11": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765"
  },
  "r110": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585"
  },
  "r111": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(f)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585"
  },
  "r112": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585"
  },
  "r113": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "27",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3581-108585"
  },
  "r114": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585"
  },
  "r115": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585"
  },
  "r116": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585"
  },
  "r117": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3044-108585"
  },
  "r118": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513485&loc=d3e4297-108586"
  },
  "r119": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513485&loc=d3e4304-108586"
  },
  "r12": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765"
  },
  "r120": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513485&loc=d3e4313-108586"
  },
  "r121": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513485&loc=d3e4332-108586"
  },
  "r122": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513485&loc=SL98516268-108586"
  },
  "r123": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=98513396&loc=SL94080479-196980"
  },
  "r124": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=84158767&loc=d3e18780-107790"
  },
  "r125": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=84158767&loc=d3e18823-107790"
  },
  "r126": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08(h)(2))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r127": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08(h))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r128": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08(m)(1)(iii))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r129": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(e),(f))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r13": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765"
  },
  "r130": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(h)(1)(i))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r131": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(h))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r132": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(i)(2))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r133": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(i)(4))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r134": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(i))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r135": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.4-08.(n)(2))",
   "Topic": "235",
   "URI": "http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690"
  },
  "r136": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "235",
   "URI": "http://asc.fasb.org/topic&trid=2122369"
  },
  "r137": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "250",
   "URI": "http://asc.fasb.org/extlink&oid=109234566&loc=d3e22499-107794"
  },
  "r138": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "11",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "250",
   "URI": "http://asc.fasb.org/extlink&oid=109234566&loc=d3e22694-107794"
  },
  "r139": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1448-109256"
  },
  "r14": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6801-107765"
  },
  "r140": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e2646-109256"
  },
  "r141": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "16",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1505-109256"
  },
  "r142": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1252-109256"
  },
  "r143": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1500-109256"
  },
  "r144": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1278-109256"
  },
  "r145": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "40",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1930-109256"
  },
  "r146": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "60B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=SL5780133-109256"
  },
  "r147": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109260490&loc=d3e1337-109256"
  },
  "r148": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257"
  },
  "r149": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257"
  },
  "r15": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6911-107765"
  },
  "r150": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257"
  },
  "r151": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=6371337&loc=d3e3630-109257"
  },
  "r152": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "52",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "260",
   "URI": "http://asc.fasb.org/extlink&oid=109256448&loc=d3e4984-109258"
  },
  "r153": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "270",
   "URI": "http://asc.fasb.org/extlink&oid=109236672&loc=d3e543-108305"
  },
  "r154": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "270",
   "URI": "http://asc.fasb.org/extlink&oid=109225645&loc=d3e1280-108306"
  },
  "r155": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "270",
   "URI": "http://asc.fasb.org/topic&trid=2126967"
  },
  "r156": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "272",
   "URI": "http://asc.fasb.org/extlink&oid=6373374&loc=d3e70478-108055"
  },
  "r157": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e5967-108592"
  },
  "r158": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e5967-108592"
  },
  "r159": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e5967-108592"
  },
  "r16": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6935-107765"
  },
  "r160": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "11",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6161-108592"
  },
  "r161": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6191-108592"
  },
  "r162": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "16",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6327-108592"
  },
  "r163": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "18",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6351-108592"
  },
  "r164": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "18",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6351-108592"
  },
  "r165": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6404-108592"
  },
  "r166": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "21",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6442-108592"
  },
  "r167": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6061-108592"
  },
  "r168": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6132-108592"
  },
  "r169": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "275",
   "URI": "http://asc.fasb.org/extlink&oid=99393423&loc=d3e6143-108592"
  },
  "r17": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e7018-107765"
  },
  "r170": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "275",
   "URI": "http://asc.fasb.org/topic&trid=2134479"
  },
  "r171": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599"
  },
  "r172": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599"
  },
  "r173": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599"
  },
  "r174": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(h)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599"
  },
  "r175": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8736-108599"
  },
  "r176": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8813-108599"
  },
  "r177": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "32",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e8933-108599"
  },
  "r178": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "40",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e9031-108599"
  },
  "r179": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "41",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e9038-108599"
  },
  "r18": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6361739&loc=d3e7789-107766"
  },
  "r180": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "42",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "280",
   "URI": "http://asc.fasb.org/extlink&oid=115929826&loc=d3e9054-108599"
  },
  "r181": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "310",
   "URI": "http://asc.fasb.org/extlink&oid=82891408&loc=d3e4531-111522"
  },
  "r182": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB Topic 4.E)",
   "Topic": "310",
   "URI": "http://asc.fasb.org/extlink&oid=27010918&loc=d3e74512-122707"
  },
  "r183": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=109979856&loc=d3e26610-111562"
  },
  "r184": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=109979856&loc=SL6284422-111562"
  },
  "r185": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=82897076&loc=d3e27161-111563"
  },
  "r186": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(aa)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=82897076&loc=d3e27161-111563"
  },
  "r187": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=82897076&loc=d3e27161-111563"
  },
  "r188": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=82897076&loc=d3e27161-111563"
  },
  "r189": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "320",
   "URI": "http://asc.fasb.org/extlink&oid=82897076&loc=d3e27357-111563"
  },
  "r19": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(1))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r190": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "320",
   "URI": "http://asc.fasb.org/topic&trid=2196928"
  },
  "r191": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "321",
   "URI": "http://asc.fasb.org/extlink&oid=84241550&loc=SL75117546-209714"
  },
  "r192": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "10",
   "Topic": "323",
   "URI": "http://asc.fasb.org/extlink&oid=66022186&loc=d3e32014-111567"
  },
  "r193": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "323",
   "URI": "http://asc.fasb.org/extlink&oid=109237563&loc=d3e33749-111570"
  },
  "r194": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(1)",
   "Topic": "323",
   "URI": "http://asc.fasb.org/extlink&oid=114001798&loc=d3e33918-111571"
  },
  "r195": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "35",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=68049868&loc=SL66093879-108312"
  },
  "r196": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1C",
   "Publisher": "FASB",
   "Section": "35",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=68049868&loc=SL66093883-108312"
  },
  "r197": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "35",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=68049868&loc=d3e3927-108312"
  },
  "r198": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=66092785&loc=d3e4492-108314"
  },
  "r199": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=66092785&loc=d3e4542-108314"
  },
  "r2": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222160&loc=SL51721523-107759"
  },
  "r20": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(12))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r200": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "330",
   "URI": "http://asc.fasb.org/extlink&oid=66092785&loc=d3e4556-108314"
  },
  "r201": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=99380562&loc=d3e13770-109266"
  },
  "r202": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=77989000&loc=SL49117168-202975"
  },
  "r203": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=108376223&loc=d3e13816-109267"
  },
  "r204": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=6388964&loc=d3e16212-109274"
  },
  "r205": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=6388964&loc=d3e16225-109274"
  },
  "r206": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(a)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275"
  },
  "r207": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275"
  },
  "r208": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(d)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16265-109275"
  },
  "r209": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "((a)(1),(b))",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r21": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(13))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r210": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(a)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r211": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(a)(1)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r212": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(a)(2)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r213": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(a)(3)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r214": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r215": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(d)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275"
  },
  "r216": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)",
   "Topic": "350",
   "URI": "http://asc.fasb.org/extlink&oid=66006027&loc=d3e16373-109275"
  },
  "r217": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "360",
   "URI": "http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229"
  },
  "r218": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "360",
   "URI": "http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229"
  },
  "r219": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "360",
   "URI": "http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229"
  },
  "r22": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(14))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r220": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "360",
   "URI": "http://asc.fasb.org/extlink&oid=6391035&loc=d3e2868-110229"
  },
  "r221": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "360",
   "URI": "http://asc.fasb.org/extlink&oid=109226691&loc=d3e2941-110230"
  },
  "r222": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "420",
   "URI": "http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869"
  },
  "r223": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)(2)",
   "Topic": "420",
   "URI": "http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869"
  },
  "r224": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB TOPIC 5.P.4(b))",
   "Topic": "420",
   "URI": "http://asc.fasb.org/extlink&oid=115931487&loc=d3e140904-122747"
  },
  "r225": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB Topic 5.P.4(b)(2))",
   "Topic": "420",
   "URI": "http://asc.fasb.org/extlink&oid=115931487&loc=d3e140904-122747"
  },
  "r226": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "450",
   "URI": "http://asc.fasb.org/extlink&oid=82911808&loc=d3e14326-108349"
  },
  "r227": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "450",
   "URI": "http://asc.fasb.org/topic&trid=2127136"
  },
  "r228": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=99376301&loc=SL5988623-112600"
  },
  "r229": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=6802200&loc=SL6230698-112601"
  },
  "r23": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(19))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r230": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "20",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=109126253&loc=d3e4724-112606"
  },
  "r231": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "22",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "20",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=51819886&loc=SL6014347-161799"
  },
  "r232": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=109500613&loc=SL6031897-161870"
  },
  "r233": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(b)",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=109500613&loc=SL6031898-161870"
  },
  "r234": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(c)",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=109500613&loc=SL6031898-161870"
  },
  "r235": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=109500613&loc=SL6036836-161870"
  },
  "r236": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "40",
   "SubTopic": "50",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=114001942&loc=d3e12317-112629"
  },
  "r237": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "40",
   "SubTopic": "50",
   "Topic": "470",
   "URI": "http://asc.fasb.org/extlink&oid=114001942&loc=d3e12355-112629"
  },
  "r238": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "470",
   "URI": "http://asc.fasb.org/topic&trid=2208564"
  },
  "r239": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21463-112644"
  },
  "r24": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(2))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r240": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21475-112644"
  },
  "r241": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21506-112644"
  },
  "r242": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21506-112644"
  },
  "r243": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21521-112644"
  },
  "r244": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=109259400&loc=d3e21538-112644"
  },
  "r245": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.3-04)",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=27012166&loc=d3e187085-122770"
  },
  "r246": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "30",
   "Topic": "505",
   "URI": "http://asc.fasb.org/extlink&oid=6405686&loc=d3e22802-112653"
  },
  "r247": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "505",
   "URI": "http://asc.fasb.org/topic&trid=2208762"
  },
  "r248": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=82913815&loc=SL49130531-203044"
  },
  "r249": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=82913815&loc=SL49130532-203044"
  },
  "r25": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(20))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r250": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=82913815&loc=SL49130533-203044"
  },
  "r251": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=109196051&loc=SL49130539-203045"
  },
  "r252": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=109196051&loc=SL49130543-203045"
  },
  "r253": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=109196051&loc=SL49130545-203045"
  },
  "r254": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=109196051&loc=SL49130549-203045"
  },
  "r255": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=109196051&loc=SL49130549-203045"
  },
  "r256": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "91",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=108792157&loc=SL49130690-203046-203046"
  },
  "r257": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "91",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=108792157&loc=SL49130690-203046-203046"
  },
  "r258": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "91",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=108792157&loc=SL49130690-203046-203046"
  },
  "r259": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "91",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Subparagraph": "(f)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=108792157&loc=SL49130690-203046-203046"
  },
  "r26": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(22))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r260": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(i)(1)",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=113356391&loc=SL49131195-203048"
  },
  "r261": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Topic": "606",
   "URI": "http://asc.fasb.org/extlink&oid=113356391&loc=SL49131195-203048"
  },
  "r262": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "606",
   "URI": "http://asc.fasb.org/topic&trid=49130388"
  },
  "r263": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(d)(ii)",
   "Topic": "715",
   "URI": "http://asc.fasb.org/extlink&oid=108410482&loc=d3e1928-114920"
  },
  "r264": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(d)(iv)(01)",
   "Topic": "715",
   "URI": "http://asc.fasb.org/extlink&oid=108410482&loc=d3e1928-114920"
  },
  "r265": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(n)",
   "Topic": "715",
   "URI": "http://asc.fasb.org/extlink&oid=108410482&loc=d3e1928-114920"
  },
  "r266": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "17",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Topic": "715",
   "URI": "http://asc.fasb.org/extlink&oid=112275985&loc=d3e4179-114921"
  },
  "r267": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "19A",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "10",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=107668666&loc=SL79513924-113897"
  },
  "r268": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "35",
   "SubTopic": "10",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=79507207&loc=d3e4534-113899"
  },
  "r269": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901"
  },
  "r27": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(24))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r270": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901"
  },
  "r271": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901"
  },
  "r272": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5047-113901"
  },
  "r273": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(1)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r274": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r275": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a),(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r276": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b),(f)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r277": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r278": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)(i)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r279": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)(i)-(ii)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r28": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(26)(a))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r280": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)(iii)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r281": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)(iv)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r282": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)(iv)(3)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r283": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r284": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)(i)-(ii)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r285": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)(iii)(1)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r286": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)(iii)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r287": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)(iii)(3)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r288": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(iii)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r289": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r29": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(26)(b))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r290": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)(1)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r291": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(d)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r292": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r293": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(e)(1)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r294": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(f)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r295": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(f)(2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r296": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(f)(2)(i)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r297": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(f)(2)(ii)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r298": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(f)(2)(iv)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r299": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r3": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222160&loc=SL51721525-107759"
  },
  "r30": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(28))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r300": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(i)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r301": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=d3e5070-113901"
  },
  "r302": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109197908&loc=SL79508275-113901"
  },
  "r303": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79507997-165333"
  },
  "r304": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79507997-165333"
  },
  "r305": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508013-165333"
  },
  "r306": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508013-165333"
  },
  "r307": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508029-165333"
  },
  "r308": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508029-165333"
  },
  "r309": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508043-165333"
  },
  "r31": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(29))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r310": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508043-165333"
  },
  "r311": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508057-165333"
  },
  "r312": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Subparagraph": "(g)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109253770&loc=SL79508057-165333"
  },
  "r313": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB Topic 14.D.2)",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=115993241&loc=d3e301413-122809"
  },
  "r314": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109196918&loc=d3e11149-113907"
  },
  "r315": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Topic": "718",
   "URI": "http://asc.fasb.org/extlink&oid=109196918&loc=d3e11178-113907"
  },
  "r316": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "730",
   "URI": "http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373"
  },
  "r317": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=115928272&loc=d3e28680-109314"
  },
  "r318": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=115928272&loc=d3e28680-109314"
  },
  "r319": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "25",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=115928272&loc=d3e28446-109314"
  },
  "r32": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(3))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r320": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=SL37586934-109318"
  },
  "r321": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=d3e32059-109318"
  },
  "r322": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=d3e32123-109318"
  },
  "r323": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "25",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=d3e32247-109318"
  },
  "r324": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=d3e32280-109318"
  },
  "r325": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84176650&loc=d3e31917-109318"
  },
  "r326": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32672-109319"
  },
  "r327": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319"
  },
  "r328": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32698-109319"
  },
  "r329": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32718-109319"
  },
  "r33": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(30)(a)(1))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r330": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319"
  },
  "r331": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(1)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319"
  },
  "r332": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(2)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319"
  },
  "r333": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319"
  },
  "r334": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=SL6600010-109319"
  },
  "r335": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "17",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32809-109319"
  },
  "r336": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "19",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32840-109319"
  },
  "r337": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319"
  },
  "r338": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319"
  },
  "r339": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b),(c)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319"
  },
  "r34": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(30)(a)(3))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r340": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319"
  },
  "r341": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319"
  },
  "r342": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32847-109319"
  },
  "r343": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319"
  },
  "r344": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32559-109319"
  },
  "r345": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32621-109319"
  },
  "r346": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32632-109319"
  },
  "r347": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319"
  },
  "r348": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319"
  },
  "r349": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=84230637&loc=d3e32639-109319"
  },
  "r35": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(30))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r350": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "51",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=109238393&loc=d3e34017-109320"
  },
  "r351": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB Topic 6.I.7)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=34349781&loc=d3e330036-122817"
  },
  "r352": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=109238882&loc=d3e38679-109324"
  },
  "r353": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "20",
   "Subparagraph": "(b)",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=109238882&loc=d3e38679-109324"
  },
  "r354": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "05",
   "SubTopic": "30",
   "Topic": "740",
   "URI": "http://asc.fasb.org/extlink&oid=65884525&loc=d3e40913-109327"
  },
  "r355": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "740",
   "URI": "http://asc.fasb.org/topic&trid=2144680"
  },
  "r356": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "05",
   "SubTopic": "10",
   "Subparagraph": "(a)-(d)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=6909625&loc=d3e227-128457"
  },
  "r357": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=79982066&loc=d3e1392-128463"
  },
  "r358": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=79982066&loc=d3e1486-128463"
  },
  "r359": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "37",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=108330185&loc=d3e2207-128464"
  },
  "r36": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(31))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r360": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(c)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=84161108&loc=d3e4845-128472"
  },
  "r361": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=84161108&loc=d3e4845-128472"
  },
  "r362": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=77890550&loc=d3e5263-128473"
  },
  "r363": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Subparagraph": "(c)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=77890550&loc=d3e5333-128473"
  },
  "r364": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "31",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=77890550&loc=d3e5419-128473"
  },
  "r365": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "38",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=77890550&loc=d3e5504-128473"
  },
  "r366": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "38",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=77890550&loc=d3e5504-128473"
  },
  "r367": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "30",
   "SubTopic": "30",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=109124213&loc=d3e6578-128477"
  },
  "r368": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "30",
   "SubTopic": "30",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=109124213&loc=d3e6613-128477"
  },
  "r369": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479"
  },
  "r37": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(32))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r370": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)(1)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479"
  },
  "r371": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Subparagraph": "(b)(4)",
   "Topic": "805",
   "URI": "http://asc.fasb.org/extlink&oid=35744584&loc=d3e6927-128479"
  },
  "r372": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "805",
   "URI": "http://asc.fasb.org/topic&trid=2303972"
  },
  "r373": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108774443&loc=SL4568447-111683"
  },
  "r374": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "16",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108774443&loc=SL4568740-111683"
  },
  "r375": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "19",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108774443&loc=SL4569616-111683"
  },
  "r376": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=109239629&loc=d3e5614-111684"
  },
  "r377": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)(1)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684"
  },
  "r378": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684"
  },
  "r379": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c),(3)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=109239629&loc=SL4573702-111684"
  },
  "r38": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02(4))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r380": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=109239629&loc=SL4582445-111684"
  },
  "r381": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=d3e5710-111685"
  },
  "r382": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=d3e5728-111685"
  },
  "r383": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=SL6759159-111685"
  },
  "r384": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=SL6759159-111685"
  },
  "r385": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "6",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=d3e5747-111685"
  },
  "r386": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "9",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=108788376&loc=SL6228884-111685"
  },
  "r387": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4I",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=84234705&loc=SL4590271-111686"
  },
  "r388": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4J",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=84234705&loc=SL4591551-111686"
  },
  "r389": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4K",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=84234705&loc=SL4591552-111686"
  },
  "r39": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.1)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r390": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.3A-02)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=27015204&loc=d3e355033-122828"
  },
  "r391": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.3A-03)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=27015204&loc=d3e355100-122828"
  },
  "r392": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SAB Topic 5.E)",
   "Topic": "810",
   "URI": "http://asc.fasb.org/extlink&oid=27015204&loc=d3e355146-122828"
  },
  "r393": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "810",
   "URI": "http://asc.fasb.org/topic&trid=2197479"
  },
  "r394": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5579240-113959"
  },
  "r395": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5579245-113959"
  },
  "r396": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5580258-113959"
  },
  "r397": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=d3e41620-113959"
  },
  "r398": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=d3e41638-113959"
  },
  "r399": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5618551-113959"
  },
  "r4": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(b)",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222650&loc=d3e1361-107760"
  },
  "r40": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.12)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r400": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)(1)",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5618551-113959"
  },
  "r401": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5624163-113959"
  },
  "r402": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(1)",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5624163-113959"
  },
  "r403": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5624163-113959"
  },
  "r404": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4C",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5624171-113959"
  },
  "r405": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4D",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=SL5624177-113959"
  },
  "r406": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=d3e41641-113959"
  },
  "r407": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "815",
   "URI": "http://asc.fasb.org/extlink&oid=109980867&loc=d3e41678-113959"
  },
  "r408": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19190-110258"
  },
  "r409": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r41": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.13(a))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r410": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r411": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(bb)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r412": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(bbb)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r413": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(bbb)(2)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r414": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r415": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(2)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r416": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(c)(3)",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r417": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19207-110258"
  },
  "r418": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2C",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=SL7498348-110258"
  },
  "r419": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "820",
   "URI": "http://asc.fasb.org/extlink&oid=99377789&loc=d3e19279-110258"
  },
  "r42": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.13)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r420": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=99377092&loc=SL75136599-209740"
  },
  "r421": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=109250915&loc=d3e13531-108611"
  },
  "r422": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "21",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=109250915&loc=d3e13537-108611"
  },
  "r423": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "21",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=109250915&loc=d3e13537-108611"
  },
  "r424": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "30",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=75031198&loc=d3e14172-108612"
  },
  "r425": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "65",
   "SubTopic": "10",
   "Topic": "825",
   "URI": "http://asc.fasb.org/extlink&oid=75032774&loc=SL75039408-165497"
  },
  "r426": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "830",
   "URI": "http://asc.fasb.org/extlink&oid=6450222&loc=d3e30840-110895"
  },
  "r427": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "230",
   "Topic": "830",
   "URI": "http://asc.fasb.org/extlink&oid=98513438&loc=d3e33268-110906"
  },
  "r428": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Subparagraph": "(b,c)",
   "Topic": "830",
   "URI": "http://asc.fasb.org/extlink&oid=109240241&loc=d3e32211-110900"
  },
  "r429": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "30",
   "Topic": "830",
   "URI": "http://asc.fasb.org/extlink&oid=6450520&loc=d3e32583-110901"
  },
  "r43": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.14)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r430": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "835",
   "URI": "http://asc.fasb.org/extlink&oid=6450988&loc=d3e26243-108391"
  },
  "r431": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Topic": "835",
   "URI": "http://asc.fasb.org/extlink&oid=114775744&loc=d3e28541-108399"
  },
  "r432": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Topic": "835",
   "URI": "http://asc.fasb.org/extlink&oid=114775744&loc=d3e28551-108399"
  },
  "r433": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "30",
   "Topic": "835",
   "URI": "http://asc.fasb.org/extlink&oid=114775744&loc=d3e28555-108399"
  },
  "r434": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "30",
   "Topic": "835",
   "URI": "http://asc.fasb.org/extlink&oid=114775985&loc=d3e28878-108400"
  },
  "r435": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "40",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Subparagraph": "(Note 3)",
   "Topic": "840",
   "URI": "http://asc.fasb.org/extlink&oid=82846649&loc=d3e38371-112697"
  },
  "r436": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "840",
   "URI": "http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717"
  },
  "r437": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(b)",
   "Topic": "840",
   "URI": "http://asc.fasb.org/extlink&oid=77902758&loc=d3e41502-112717"
  },
  "r438": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(a)",
   "Topic": "840",
   "URI": "http://asc.fasb.org/extlink&oid=84164653&loc=d3e41551-112718"
  },
  "r439": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "840",
   "URI": "http://asc.fasb.org/topic&trid=2208923"
  },
  "r44": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.17)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r440": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "SubTopic": "20",
   "Topic": "842",
   "URI": "http://asc.fasb.org/subtopic&trid=77888251"
  },
  "r441": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "850",
   "URI": "http://asc.fasb.org/extlink&oid=6457730&loc=d3e39549-107864"
  },
  "r442": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "850",
   "URI": "http://asc.fasb.org/extlink&oid=6457730&loc=d3e39599-107864"
  },
  "r443": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "850",
   "URI": "http://asc.fasb.org/extlink&oid=6457730&loc=d3e39603-107864"
  },
  "r444": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "850",
   "URI": "http://asc.fasb.org/topic&trid=2122745"
  },
  "r445": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "10",
   "Topic": "855",
   "URI": "http://asc.fasb.org/extlink&oid=6842918&loc=SL6314017-165662"
  },
  "r446": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(bb)",
   "Topic": "860",
   "URI": "http://asc.fasb.org/extlink&oid=109247956&loc=d3e107207-111719"
  },
  "r447": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(bb)(1)",
   "Topic": "860",
   "URI": "http://asc.fasb.org/extlink&oid=109247956&loc=d3e107207-111719"
  },
  "r448": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(bb)(2)",
   "Topic": "860",
   "URI": "http://asc.fasb.org/extlink&oid=109247956&loc=d3e107207-111719"
  },
  "r449": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(bb)(3)",
   "Topic": "860",
   "URI": "http://asc.fasb.org/extlink&oid=109247956&loc=d3e107207-111719"
  },
  "r45": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.19(a))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r450": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "50",
   "Topic": "860",
   "URI": "http://asc.fasb.org/extlink&oid=68078379&loc=d3e122625-111746"
  },
  "r451": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "340",
   "Topic": "928",
   "URI": "http://asc.fasb.org/extlink&oid=6473545&loc=d3e61844-108004"
  },
  "r452": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(a)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e61929-109447"
  },
  "r453": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(b)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e61929-109447"
  },
  "r454": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(a)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62059-109447"
  },
  "r455": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "20",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(b)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62059-109447"
  },
  "r456": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(a)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62395-109447"
  },
  "r457": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "28",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(b)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62395-109447"
  },
  "r458": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "33",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(a)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62479-109447"
  },
  "r459": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "33",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(b)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e62479-109447"
  },
  "r46": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.19,20)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r460": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "35A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(a)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=SL6807758-109447"
  },
  "r461": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "35A",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(b)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=SL6807758-109447"
  },
  "r462": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(c)(1)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e61872-109447"
  },
  "r463": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "8",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "235",
   "Subparagraph": "(c)(2)",
   "Topic": "932",
   "URI": "http://asc.fasb.org/extlink&oid=68064819&loc=d3e61872-109447"
  },
  "r464": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(11))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r465": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(13))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r466": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(15)(2))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r467": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(15)(5))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r468": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(16))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r469": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(23))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r47": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.19-26)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r470": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(4))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r471": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(5))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r472": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(6)(a)(1))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r473": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03(6))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r474": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03.15(5))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r475": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.9-03.17)",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=6876686&loc=d3e534808-122878"
  },
  "r476": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(19))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r477": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.9-04(13)(f))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r478": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.9-04(20))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r479": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.9-04(22))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r48": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.20)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r480": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.9-04(23))",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r481": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.9-04.9)",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=114873765&loc=SL114874048-224260"
  },
  "r482": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "470",
   "Subparagraph": "e",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=75038535&loc=d3e64711-112823"
  },
  "r483": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "470",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=75038535&loc=d3e64711-112823"
  },
  "r484": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "825",
   "Topic": "942",
   "URI": "http://asc.fasb.org/extlink&oid=108315417&loc=d3e61044-112788"
  },
  "r485": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(15)(b)(2))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r486": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(16))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r487": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(1)(b))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r488": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(1)(g))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r489": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(12))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r49": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.21)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r490": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(15)(a))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r491": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(23)(a)(4))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r492": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(25))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r493": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(5))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r494": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03(a)(8))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r495": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03.(a),19)",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r496": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.7-03.15(a))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6879938&loc=d3e572229-122910"
  },
  "r497": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(10))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r498": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(11))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r499": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(12))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r5": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222650&loc=d3e1361-107760"
  },
  "r50": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.22(a)(1))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r500": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(18))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r501": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04(19))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r502": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "220",
   "Subparagraph": "(SX 210.7-04.3(a))",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=114873790&loc=SL114874131-224263"
  },
  "r503": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4H",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "40",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=99384497&loc=SL65671331-158438"
  },
  "r504": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "80",
   "Subparagraph": "(e)",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=6484115&loc=d3e19393-158473"
  },
  "r505": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "825",
   "Topic": "944",
   "URI": "http://asc.fasb.org/extlink&oid=99380617&loc=SL75241803-196195"
  },
  "r506": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.6-04(13))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=6488278&loc=d3e603758-122996"
  },
  "r507": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "210",
   "Subparagraph": "(SX 210.6-06(3))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=6488278&loc=d3e604059-122996"
  },
  "r508": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "305",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=6488471&loc=d3e14834-115856"
  },
  "r509": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "320",
   "Subparagraph": "(SX 210.12-12(2)(i))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=50485924&loc=d3e611133-123010"
  },
  "r51": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.22(a)(5))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r510": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "4",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "320",
   "Subparagraph": "(SX 210.12-12C(1)(a))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=50485924&loc=d3e611225-123010"
  },
  "r511": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "320",
   "Subparagraph": "(SX 210.12-13(1))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=50485924&loc=d3e611282-123010"
  },
  "r512": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "320",
   "Subparagraph": "(SX 210.12-15(Column A))",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=50485924&loc=d3e611379-123010"
  },
  "r513": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "7",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "320",
   "Subparagraph": "(SX 210.12-15)",
   "Topic": "946",
   "URI": "http://asc.fasb.org/extlink&oid=50485924&loc=d3e611379-123010"
  },
  "r514": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "310",
   "Subparagraph": "(SX 210.12-29(Footnote 4))",
   "Topic": "948",
   "URI": "http://asc.fasb.org/extlink&oid=6589523&loc=d3e617274-123014"
  },
  "r515": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "740",
   "Topic": "954",
   "URI": "http://asc.fasb.org/extlink&oid=6491622&loc=d3e9504-115650"
  },
  "r516": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "360",
   "Subparagraph": "(SX 210.12-28(Footnote 2))",
   "Topic": "970",
   "URI": "http://asc.fasb.org/extlink&oid=6590653&loc=d3e638233-123024"
  },
  "r517": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "360",
   "Subparagraph": "(SX 210.12-28)",
   "Topic": "970",
   "URI": "http://asc.fasb.org/extlink&oid=6590653&loc=d3e638233-123024"
  },
  "r518": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Topic": "985",
   "URI": "http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756"
  },
  "r519": {
   "Name": "Regulation 12B",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "12",
   "Subsection": "b-2"
  },
  "r52": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.22)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r520": {
   "Article": "12",
   "Name": "Regulation S-X (SX)",
   "Number": "210",
   "Publisher": "SEC",
   "Section": "13",
   "Sentence": "Column A"
  },
  "r53": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.24)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r54": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.25)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r55": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.29-31)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r56": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.3(a),(b))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r57": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.6(a))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r58": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.6(b))",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r59": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.8)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r6": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5C",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(b)(2)",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=109222650&loc=SL51721675-107760"
  },
  "r60": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-02.9)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682"
  },
  "r61": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "50",
   "SubTopic": "20",
   "Subparagraph": "(c)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=51824906&loc=SL20225862-175312"
  },
  "r62": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "16",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "20",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=99393222&loc=SL20226024-175313"
  },
  "r63": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "210",
   "URI": "http://asc.fasb.org/topic&trid=2122208"
  },
  "r64": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669646-108580"
  },
  "r65": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(e)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669646-108580"
  },
  "r66": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "10A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669646-108580"
  },
  "r67": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "11",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=d3e637-108580"
  },
  "r68": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=d3e681-108580"
  },
  "r69": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669686-108580"
  },
  "r7": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "3",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "20",
   "Topic": "205",
   "URI": "http://asc.fasb.org/extlink&oid=26872618&loc=d3e7436-122677"
  },
  "r70": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=d3e689-108580"
  },
  "r71": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "17A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL34724391-108580"
  },
  "r72": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "17B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL34724394-108580"
  },
  "r73": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669619-108580"
  },
  "r74": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669619-108580"
  },
  "r75": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1A",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669619-108580"
  },
  "r76": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669625-108580"
  },
  "r77": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1B",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=SL7669625-108580"
  },
  "r78": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "5",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=114867106&loc=d3e557-108580"
  },
  "r79": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "15",
   "Publisher": "FASB",
   "Section": "55",
   "SubTopic": "10",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=109228884&loc=d3e1436-108581"
  },
  "r8": {
   "Name": "Accounting Standards Codification",
   "Publisher": "FASB",
   "Topic": "205",
   "URI": "http://asc.fasb.org/topic&trid=2122149"
  },
  "r80": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(13))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868656-224227"
  },
  "r81": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(210.5-03(11))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r82": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(12))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r83": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(14))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r84": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(20))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r85": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(21))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r86": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(4))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r87": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03(b)(2))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r88": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03.2(a),(d))",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r89": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03.2)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r9": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "1",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "210",
   "URI": "http://asc.fasb.org/extlink&oid=82887183&loc=d3e6676-107765"
  },
  "r90": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03.4)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r91": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03.7)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r92": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "2",
   "Publisher": "FASB",
   "Section": "S99",
   "SubTopic": "10",
   "Subparagraph": "(SX 210.5-03.9)",
   "Topic": "220",
   "URI": "http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227"
  },
  "r93": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585"
  },
  "r94": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "12",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585"
  },
  "r95": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585"
  },
  "r96": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(c)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585"
  },
  "r97": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "13",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3213-108585"
  },
  "r98": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(a)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585"
  },
  "r99": {
   "Name": "Accounting Standards Codification",
   "Paragraph": "14",
   "Publisher": "FASB",
   "Section": "45",
   "SubTopic": "10",
   "Subparagraph": "(b)",
   "Topic": "230",
   "URI": "http://asc.fasb.org/extlink&oid=109223946&loc=d3e3255-108585"
  }
 },
 "version": "2.0"
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>86
<FILENAME>0000886163-19-000041-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 0000886163-19-000041-xbrl.zip
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MX6QW/!F<4NY \DT@Z5WFCI@K)@JR_Z^#(D&S+A<N-I2M"VB0".*#1U;\B[5
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MF\+JAC%@!ZM6P.I2%"BU"K%@DYTJ=<UNC@*5DTURUFFC1$S2,ZR^85#T-H+
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M]Q4'5L=8-P/6)<;R4*!(2(VJ2SZ#(6J"KA64V4\Y54!:R L$EM(A*Q<U\V,
MI4N0SDLM4S).QTBV8ZP6 ^M*EJAS(1/YV(!VJ8KWU&#14'NTO#491<[IP2-O
M'KIOJ+/16F!UC'4S8%UB+.M+2E!*HZ)T#*R8FN P-<(:)8OTV9&K:3/BH5Z(
M>@_1DV0X%9.!E3P[7,K9YZ)-D3(GTU%6BY'U].CYUL62)'4]$F<EUM6,=*GR
MW<K&BYB;$%G*6Q9<:&2%EGPH%Y+KM^+0ZDCKIM!Z\0%:%+R5F14[:&2?F'5I
MV 6F)D<*R1HA3*Y%%X-Y&!:2E*4-TZ1VL3ABWRN<CT;7L<GHH2[(M.Q>THZU
M;@2MX\NL91)&K8)O:G842_@<&Y3DFJQE"=&QT*K=I(M*?%]Q8'6<=5-@7>(L
MP7ZP>-MDH>L2;L8W=0V<1A)ZXQ5&5PN:_3-G75\AH<X24U91+AQU8D:"K(HR
MEK]1D6=BW8APAB'^H,6WE+^?H^0E'1Q.TBY6<(S?3G#_; G7C=&S\2116V=N
M75W9\_=W.WO/^$\ZVGS]USLV(=_OX]W^Z<;QYM;.L+?^U_[.;Z^.-]>?U@QA
MZ+]]0TH&'PPUAO]A5V3KK'..^TEAR!#(I5JD_)\6-:C?=P<YTYF%)U1H0J-$
MTT>_#@>C=[],TR[M(YOYI^/Y]]G) 5MF.M@_&#*3G/W&IV<4#-^.\@>*>'@\
MS0_X[%?/<7:YR]>8?YV.V;+UVW&<# >_G$/KW*!28W"2PX(@P$D1@Z]KB8+S
M(C-FK\W NC@1C6:#V<G%MT&NW\N )C_-;X@?8W<V._CEYY^/CHX>,@(?OAV_
M__G)QO\\>%27/N6H5EK]Z\^?'OSHXJ>K9S^8H_'BVW2&D]DZSNA1O:F&;T[(
MB^,^;OMPF_GCKE(U6GZ\Q-F6B^\7%_GYRHNZ.$\E^_E+.YR_^[,?]\^6P7XT
MF(Y!2??+JS_7+PZ_V'3QO1Y_K0V,<]X6!%$R"^>8F330"4"V(TIEP_GRS)9;
M]?)?_6#$+W@T.W_QMM'BPXG.MWSCVYS.'==G+_3<F/.-W_Q&G=,J"Z=3 0)O
MM2=&N;6H=;#9NK,5R()0RJS6&PV-4(TRW_=&K[R!;UB#;:7>P"<M] 9OH-3I
M9LG*0,F#@!)MG52?ZXA3BJJX^1MPJ_<&W$W>P&6.^B!(+S;F05V_^_*N<S>%
ML_'D.^GLL^/KC^LT&N\/1M>=]FL;]953_'SU[K_4]H$<<RD3*"H)F.I:=I(Y
M@&4XB_ 2KQT]OF4 G#\VO:TSY<^^9K[8\<%PD :S'M7*:C_E 6^MJR@S)4YF
M=4VB?)AFFY,_:?*>U?K:\8!)\D*RO1R?X'!V<G;HV24_.^.'5_7APJOJ6:\J
M$L,Z5P0;$OO +!4F;A-S)A-)%LK7E<7H['>M_=S7V\\MS'[@BG>ED/626==;
MM")+'U74CFPJ^KK*%)W]KK6?_7K[V879#V4)QB 4 @ MT0<IC)21/:DM-EU;
MCJ\U]JM!U"\]?C.3 0[_Q"%-G^#!C+W=\#Y2J4..+# SA:8$0!18^LF4"RG!
M.BC:5E/ITDRY%%8-OG@198+@:V)ZB6Q2HY/SQ$W3 ;6:59=FRJ40;%WU.$0V
M)V@#9#%X#E832! ^\Y]KIY"TRY3/^>MH2L^(IKT!6W,V'M$41_GBD-DN3>XC
MW]HH1?':DD^976<*'')R$[4Y8X 0=/OY=@4LNQ3Z]<HA:D4V6 MUG$@($ 2U
M.H@.)=T#^ET!RRZ%C;]G(?KE]Q<MOT5\SV+L*_;>EH*W(E6$S*C+BO&64F2_
M %IAL!X,*X)YMZ1910+Y.%S(CUZ/J<MDST[J(#1SQ6@VO1HB\^_[X]%\;''Q
MO'&IO]0LK,<80XHY&]1%2,BQ1(Y](4305B4O0K@WIEG+>5 'G7'X!P[RQHC5
M]F"&MR"V;\5,E*4E,H8(B6WC6#XG&= Z6S(DJ^Z/F5(ZW#\<\KYY[G[K?A/:
MK6=[3QNC--ZGEIB,76L@'9P7V@-)QPW-<-0:V=TJK)6)[HO)7M(,!R/*3W$R
M&HS>3EMB'Y8Z.MF"*3@-7D?D>!306F54"DK=89-:&O<GCL6-\0%%YC>0.?Z6
M2I@<HD-94FB!P%\E_[Q\G26C3]&B,>S5F7XPIN)]3B8900&PW#^#WIE77P'C
MHO+:9EEB%A"E\Y2](_8MUF-0YXG@]\NXR] "RS>TUV39BF!( M1EB(%-'8M!
M0R5:%>^?H6]?02S?JBZC9Q&?= BU'+3T5++VBL-AMG$)<2XW[H,Q[RH&M@O3
M05+*X*7+P3"S)A4]1%N49$$H.11._MZ89ADQ\.+,5#SFZ'2DD"U(QQI50# E
M9*5<!.ONCYF6' ,OSF16ABH_)21AP-LJ3:T' *&-*=+"O3'9G<; B[,/JBS1
M$Y$T%K+P*.J:3,A46$!)T'=GGZ4A5.OD2D",T0"J$#+6"*K8PK12[#*&0MKL
MGY<_1N-=L"4Z \*4NA '0@XY\R?+-O:R#?D_J^K5EV]<Z5DV)W*4,H'6'DMV
MAKP#T,E*</?0N$N/@9=B:,/\ZW5,-B<!RNJ )',)3B)[IJS$V42&:NA5M>]:
MWCN<SNI!TV?C29^.V)+C0S[MZ.T?D_&(/Z:Y^3^W]_E>#)!1QDF>OCK(_!;G
M,7_X@JU;2RU7YH)<P=M->OB#5=:FD'(@4-%Z-)D,\&LLT<B85Q]$MZ,^5QO#
MJX(>K;,J/GAP=<GDP*%F+2!KB\K&A:+BZJ/GAS:?+ &T,UXK8<$ !(>Y=O3$
M@CD[=P^EPAWWHBY%%R0K?(H)9:%2U_GQ!D%F)GETD6V;[VZ"8YNCM$7-O+P:
M>$4="GD2+-M %PAUI0 -V2J9HCJ??7L?3+,<4;0H,RDC-5-@-(%MI')= TX(
M5#XS+;*W*_?'3$ON15V<R:0EYC<H/M=A?;:5M1JSDU RTU\T]\9D=]J+ND#F
MT\)Y4P0B:O H4!2E;12YE+K*T[7K_+;;4'?7A[B4.2WS=;]BK4PJ'!BOHH 2
MV+Y&2T= >/\,NIP^Q*48EU3 ()2-@11DE3P%BI**B9 EN\1[:-RE]R$NQ=!8
MM"]% "5G(3MVGSE#"CXE@YFCPOMGZ#N. )=B519!*B)E#)C 8?"6%)J8+6'*
ML:CSPE$KW"US9ZWVJ^_H5CJ*Y*VJ-[^X?C[CZEPN96SA#]G'E&NU)# @D].>
M[@V@6M5+W!;T>"O J> I0F%E:"(Z00(2>Q@EC</51\\/;;[D2@RZCA,5 ^!R
M%-SP0YT!P1& RG+US7?_&C_<\AC#XM 3M$9'"*6.2J?D6'[8'#21M:5&&*N/
MGA_:?"D)&]%G"G4295+>IMK)!EXAH?"I10'".L79!K^)R6$]\%*)@R?CT7N:
MS 9Q2'_2:, V'L]HRH]S;U,)EA^B4"VRJJ3VVEM(*J"N\Z]*K32L.6"Y=F6L
M'P97K;2H]Q&M322]<N"3\5&E$'7R6% K<:\MJG3'%+?&%"BU0K:SB9G#3<)8
M*]8!V6Q$773MA\95*RWJ35'@2V)>(.;^$F51.3GG<I'$&N/N:E#?<D!Q5PD*
MBRN.S2+=FA)B5MJ!D2I&[[P.RLE@LPYX;TRSC 2%Q9DIUCH9X!V1"R"MB,6H
MFNFCN4TIE]S],=.2$Q069[(,:+S3P23K@'U8+!!J_7T;L^1X,-X;D]UI@L("
MFU21J!"RSE9"YH^!ZM(ZZ.H\<Q';$.C62GY_\A7SX9 VRYF5>C3;K:OUO*>S
M+HS/?R7JX_[EBG]_#=ZQW;:XM>$!'<X&:<H-[>%]%"(:;&&W5E.&$@2IF58=
M6!5J,9!:/* %^:]MMOERRM#;.G_=VQ1UY \Z:G+)@&![&'D13JQVY8@VVWPI
M=26T)^>#PBQ+ DC6.UE=L22G21ILR](?"[#Y'^=KN8W+/4]/XP;-5"YLF$^.
M\Q$IJ%J#67-H \Z&'X?:EV'RY4Q\-2IX':/(Z-F+YYB+BF021&3/+OV/P^S+
M,/E=$?N'E:Q&A_7&_V9]N /^>'&"KUX=#CDH<U&4X#Q':UF';$0$9HZ<:]7G
M-B3#50#U<&\\>7(XG7%P/)E>A@6;9$23M47U53\9CQ+?UF2^SNS+P?3=XY/'
M-$J[^SAY=S4FG*_=\)+>T^B0^C2[Q1O8.CGX9$F>BS?QV<[WT>UIH0(!HTF0
M!>T%"Q^EK=')^V@CII:XO0["*P'AY1205SIC-(6UN0870W0A(6J.S7PT6;=E
MG; .PBL!X>4LE98-)!*%T&M(SF(6RA9=DQV#EKHM?8E?@O#C#L+W5DB 3C5\
M\NB<@5 R*JUK(6R34<BLV](UVD%X)2"\G*7QK(T@HA4FF=K3BPX]F+H6C4@%
M<UO69NH@O!(07DX]\YI@;XE8#VM0*?C">D)'SU+"!U7NBY!XTD'XW@H)%KTL
M):)5I B*T:B250Y<G5P<O<-[(B0Z"-]?(2&-I.20Q;"/@""C I41, 814\3[
M(B0Z"-]?(5$"BL+*048(D+U +Z*1IE@(TL3SA;:<%,*N&G(OS/7X<#H8T72Z
MEO[W<#"=YVY>3J">G$SOH+Z4:(3]\%#?E&OV8=AJ,GB[._MLU&K^$/--WSQJ
MI6Q(Q2AVIL4P+]EHR?,OT>FLI YGE8^$D*M'2E]GVA[-,.)T,+V<J7*KAA:U
MA2XDJ5#8[(C5>J0@@1""<E3GT$J93 G2KV[29W483^K\19H<,$&=?#+"O'8Z
M.!GC*#\93WHXFPR.%T7=SP:,<WH^>$]Y8\2O_6V=$[$VG=)L^OCDS(,-<?I)
MRNGS^1K%@]';M;<3.IN+V9*L4^9<J$O,28$90C;>HE)>.&0Y@>Y\6965%<4=
M0&Z_KEUD+QV*8<K( &B"1(W:HO$Q6"]7>$+&%P#R!P[?TW"(G^0?_E P61R/
M%%T[-[5S3"% $-!"R=HEG9-TN<36\D@'DT6RB<6@LM"J9&6@%GM7BFQ=.4_$
M" R<U663.S;836'[)PV)O[6$/0BMT<HI95F<6F,0G,_)J@2V&)2TNNS1P>(6
MV2('7\LQ $A&0I(V*%*RQIDH2$K5@EF&K:#W!<YA4R)"73.3LH-L-(M%(M#)
M1<]Z,>NN':]8"XML*51)B@0"/#I$$3'%DOF_F"2L;@MKH6Q[.3[!X>RD=:W:
M9Q%,#MR:(T!6Z&V4H2BKO":75[E<0@7)2[;..3+F@Q!LN?W#_5OVLQW\%@>_
MD,E:42*34X+HF:6*SD45)UVA;'.[X(?''?Q:!3]@I6F*=198B.8$GF-8F3T'
M*-(HS*8%*3 7)M@:S.JTKHU1'KP?Y$,<7K70^F!":3:>W!0FF0:_/*>W.'PZ
M?_P;X_*F YY+RE\-H5)64#D EKI\O "=?9#"@:,V+7%Z)\W]II0W[^^_C\D?
MKB2GP8A,)8$T-DAG$KA82A: 6JZN^^OP<TLN21LE5(I:9*SS/'0$K8-%'8HO
M1I0S162%$?J'AL3-S&4;81JA%V"N$-&E(%$Y+( ^AI2" TO>H,J01=>"%]*"
MOW:D=U5:<9W70FBU3?531(_@G>3VG# 3^C:M<?.CXV/Y<C-*B01%."LE0,B8
MB)V#9_?@(#+C=&!JA5Q8/I"*4S'H4M?I.<OF"X@Z*U:?$F.==]>5R[]1W\D&
M@WO D?=!W7&>\OO'W#A/SLI,,NJ?EL)A^-8$1Y=3$3\&Z;QY0OP,CVEV1#0Z
MSU[^[7"0D7_=&)T=_YC*>$)KH[Q6&,);XX.Z+*^]9=>XL*+_X((/T5LT&C)H
M-+$DK5*QBB/EK%O$9C>U]Q,<IK/ZHZ]&F2;_:.VOM/)7<1\WE7R89IN3/VGR
M?I#H6KJ]CP1H1=%1,  U:B@)/?FH2N*PRELC<YL6"KU?V)O[W7/@\1[[F&9X
M'P$HDW-)V%#3+B$F'3C81TD<YEM?R'0 7 4 _L_)P60\O(U,FA4 H$%=4LSD
MDP8K4K3:@%1D#6616A5+W%\ /GT_WJ?AO23 P)&LR\Z!U0H,4$U((<OX2UJ6
MH%R'OQ7 W[P:_GU$G[<^$! E;P3'?2%BU.#)N&(Q>.5;-'!WO]!WM[''4L;Z
M/$KG;,@EN@ *E3<HL@--3ML46U$/_GYB;PFQQU( &#T2ZBKS,$# Y(,3616.
M.[PK)I8.@"L P#N*/98"0.,87G5X-)0"S'FA:*\=I:",#]')#H K ,"[B3V6
M@K]:;C"C+#%[!&F3IU)2'0P)-=^9=(>_%<#?7<0>RRGTXU%)E-;%Y,!X&26P
MWV446F6,T6TH]',_T7>WL<=2*O0X&:B8I*#.\\\Q!TM:)%E0%W;&4G786P'F
MNZ/88SFU)K.P,GN3T"&('-&@5E"8"K,02K1A8:S[#\ [BCV6 D O#:J0O PF
M@#;DLRE4E(@AL_0[KQ39 ?!'B#V6@C]E4X"B@HND(%L,(H*426-0&'VP'?Y6
M ']W$7LL!7W"*>V<%T7F LX21JFR) Z"P?+K%2T8=5LI#;64P2MT0H-R*F:;
M0!<;#0471 HV9PVA+0M-KHP.64X*+F%*(M<J)P5$2"&6&I%Y3S&2NT<M\1[G
M,&AA0I!H64 :L"IYI3B8R;XV2Z?R_6F(]S8/0&:%#BPDPS8368<25":M?-(Y
M2T?MM^#S>=D:>D9T+VE4&0W>*[(A$6BTT4J-,@NO8XDZYA9TY:^, 9>S4GJQ
MHGACDD3)U(F190VXY+PMR1AH0V_XRAAP*2$%69$L1,]O-(,"X8-W7AHM-&KA
M;!M*9WS!@+W!D*:S\8CN(X&B)< "I6@2X*0(+J-F0:HQ)+0JMI] [\I\2Z'/
ME'6)6%*D ,!.SV<A.0X,_&J3+N<365I-GW=EON7TQVBIC=;)B,*MSW,TX?G?
M^?(OZ(*^!U'@9>]W8<GIVBC/0XJ+X^YK>*%#3L%$K67*@+Y@\=K*PKI&1 ^^
M#?6!6F+>Y9"O1S1%)N.A@!*(M7>UEO!)Y)11;1C,;(EYET+.%JU'5D11(H!B
MC>M8)BG(I+)G)]N"HDR]L^5]ZE$;HX/#V>?K4WVZQ]/C THSRNNU>!R_NY?\
M[A9OV]NIX8<BD7>6I$Y@( 9;0M 9F'FSP1)J:Q079"ONA&R_$>;BZUE,+([%
M;#1")%5B-AHL*;392FF3CBJ(W(IUQ#^4=SC"2?X<Y$_W#X;C$Z(_9^/T;O.@
MCD3>=!SQXM1_#''T2=60K:/QUN[X<(JCS!_GU]R8+_XV>$]U]_LH=#R''R*0
M1-(:(' <$ET(:*2VE$&L</7@#^6]QZ.W,YKLKU.\AB;_I-%@/.F/9U_LP_GJ
M"]8+;3#;30[KG5XI831Z3Y-9+8ASZ;)**-T2(@Y.L (BAUX$"-GZ6AD>0U:Q
M.-(0SJO+&*7:"89+!IJ;Y@\\0?Y\?X$A3*/4 H"138@I&9431S].UJF6.AIK
M7' VZGR^4)VP,G3 : <P6&R'!0"#(<'B347(R*%4Y$ *R)J8;?292-ES"<*,
MT734L>H(^52-7":/?U8C5W:]4993$ARD&8T10#K'@"HYNF0UY.!S.8<3\TS3
M$4[;X'29<KX I\N[WF2$2\0<:L$H/<^W*L$ZLE$X79<S4\5T>F;!G1!U?>QG
M$Z*-6IB1IK.OZ(1H%Z9O15V1!5L7+A#&(: "C%E)45+Q@9+!U*FK#J:KH/6,
M\BD%!39E2+$$,@:=\#('*[)H071X)[VJ[6@T*PC3!;&IKM/"#2CM$T(1X&/*
MA$(*A4:B<*O/IAU,5QFF"V)3%J+!9$\9"X'6WJ><!/(OKE9W,6+UV?2> 6,!
MS?,L[>63S4_&AP?CT1T,QRV*0%EW)BN2X\C; H=0K$LI1.^RS@I*;@&!=LA<
M,60NB#.MSS8(4;+ FH2C@[/"EZ"15%$=9]X?9+ZD?1R,!J.W6_RN6D*;$J.V
M*N2:+P9%&2P6+67E2RE"HNUHLP/GTI@S,BI11"6ELR Y'DK$(.78G5P.(=$<
MG"#\Z@[S?S,^Y,(6!;F-=G$S8$ C_&*&_+.S=?D.EV( 9BT_7U4A>F5<09EU
M"SIU.F#<BCMSWN<H:VT?5""E#T)%E!)0)M9>Z%<_,:@#QNTD"4$LR;&TB3H!
MN>(SU<)0# 1/)7G7,<:J2JP[&2A9%?Z" E%EA8:L!A(>@U.6L8M,6JG$TO%7
M!],58-/B%0EK,"4)$ 6PG[7L=ZT'&>JLW-5GT]4:K;AGC695V#06P0[?^Q)8
M AH9HC?6(ND0I XB=3-J.IBN IL*DT(R@02"8/>O/6#M*9:Q$&N XE>?3>\9
M,!;0/._'H%I.1N;,,1,%#5*8VL\B^;LKRM;Y6JM/H!TR5PN9B^),C*"E<(0J
M$TB.Y"G)8*(PPJOL70N29#MDKMZXQ:)Z(4LHP61IM$,(WM7_&^&R3B:JB*ZC
MS0Z<RXO=;?;>D"29 GC/TM/'X$5T"J,Q'\9.I%A9</XY8S]5CWGZOX=\7T_&
M^^R[^.OT*E36QFFP,4K#P\P&^F,\F5>$GLTF@W@XJYC9&O?'H_IJ)N/AD'>Y
MZ(=9%);6\M[A=%;O<_J,VPD=K:4T/N2GY[N9C$?\,<V?XM/;_K 7/^<HXR1/
M7QUD?N*SXAZW38&7)W/?)/2V[)E%+#[&#% <*O+"\4^&P6>P3:L.WH8=I5F\
M'9=?H":ZJ&4HRA @V.(Q*.^#3"K7M:Y:M=A!*XV^E+(UL0@!3GCT$4 IA11+
M%,KXHD&7J%M4S^,O9G\VW26'?_[+V4(#FU\L"O?U\.HJARRI@*^G: 20!= 0
M0T85?2(LK-"#E@[N#UK9I!U:VX[6B,$J)XK3'@R"#W4-\:"LL$4:V89ZX>TI
M>//%$+8M$#H<#<[P,YM@C7W>9#SY (O]LQ#V[%5<VN'B7!?;+[[7DUV+3<\!
MI 1A*24"12F:(K/(*2HI$&T;_'ZM1O@21V_/P5B_]CB<WS^\A5A^^62"5CIK
M\WQ$%%#;D*/)K-&MT4(5""TU&![?5X-Q,\J4B)CH#60*'I,Q0K@0"95+*YQE
M\=T-:T'NY$?,^O^[/?Z8#!+]-:XKI T'M[',[*UTH0L+Y%%+G5,&$QQ_1$U:
MJ2Q*E&&%Q\2_FZ,Z['?8/W/4[()M8LB7J,'8C#DE3$K7<H8&35C=.5D=[_^P
MV%]4N99(2A;M&>P><C(Q1U^4+5G*F$U9X9J-'>]WV+\9]K,N  2RYK  8O)U
M2IO6$8I-1FO5+LVS6-[O$A)6%/N+FOB"H$5(&L$".&.CB((4@@S6DG"Y7=A?
M+.]WV+_?V&=[&8YQE4]U2;N"08*RAEQ*5*?5P.JFBW6\_Z-B?V&KJ"B9;'9&
M9R] 91L1BLF$3IK(%S+MPG['^QWVOV6R+P/>>B6M3)"]X;!6B>P42W^G(K5A
M)9R*^LVC$4VFNX.#RYD(@W<U*W:7)GA A[-!FFZ,TL/[.$B#0:$3P;/92ET&
M"@&EH$"B]ED'. O:5CJ_\25QNZ'\![^MDZT)CJ:8:BK']/')Y2V?I'[,,V][
M--L=YPTF@^F,;G?FB%M8JY,03 2;M1011-$A&C::+Y(C$!.<GAMLI7,36V$P
MN[BI/K9DXRT%%PJH&#QY$<@['[(##@];E$J\NI9;?O*P0LE&!2<KC7) Y$E+
M92F2,J2\LRU*'FZ)F9>2+NR, JTS*QV%$'WV_,DD)16QZ@_BTY0VH3LSWZ4L
M$GI!LJ@4TH$%KN"FG"-'=R3 FP)6^ACTV50 $.;,S/QA=<W\%TX&-;RYF!_T
MM-[>@-C,3X8XG?+9$U:[;Y;YED\,?NW1)QRP[./DY#&-B \?\,?%!8V3P7NL
M2;$?0\=::>;J7=6X[I9A![5_[.M@-]]U,2M@>UTDRS@B9T&9,%\-.R:IDM(8
MPUFM778BJXNVU265*^*.V^U"Q)TID9V\U<8Q/XC Z@Z2-4H:K2 5K\Z]/DC=
M7'SH+'=3KP^-U%_G]:_L>I,%6Y-FQX\Q2XZ2@S+>ZVA5X$A9^UH;^RQ*%DZ:
MSKHWBI+K0LUF >W2N<RTB4Y9T)#J>@^5-1T5(/+<0#\LD:@OEDB\]7;Y';K'
M-.JK@/[)KC< .GL?7W0)446.99Q DQ+9'#U@5!##N0,"+3J@W\P!0:/%(GH7
M'&B*3CDT HH%5!1\L05+]JY8UX).V LK/!N,<,1B<OCIH,'%#J]QP@:];>&W
ME&Y8\ Y=5DFF>:>0"^!5]'6I7S V*&A1)]&*F'$IG4#"9:=T,<E9=CN^>,C%
M%6^M,U TA19U JV(&9?2R5-%G22*+.^87J6*4: %$V1@7:_\^2Q;*2Y(5:RN
M&1\?3@<CFD[7$ONXZ6!>1.3RC-O)"(>#+TU:O#FE2O'UE"H68\04! I=HF>'
M"%1\<,:'1,K4(ELVRQ9YQA4QXC*&)[7/M1X#29D  WJOG'91\^\R<Z1]GE_1
M-<!_4IN?M*F;J$V4-=-+%VY%X#,%7?L]G)*1O1UD;!$QLG\;S.CYX#VQY.?W
M\;:F@ZQ-IS3C4*&'>^/)O'OTTW[']S0<'U#>HK0[&@_';T]>#M[NSA8VZWM%
M6OH2Z#J'K$-.*A (L)9\*B4HR;K)YZSTV<"*8VC9YN+#JD+KGXWX9'+";W1X
MZ_*WVM!^I?R]O.M-!L=\Y !&9)V<8.4;ZQ+%)4>'FB#9'%I@P[-V=C[H40N*
M?BC/=KF6Q^Z$IKOC81Z7E\P(HT.:8AR_)VGV!\,AG^=H,-NM._'1PR%OFLQ'
M6-;>\B_U/NZ(+NXQTHIC#:?1&(T"3,U EA@A>\S*,(/D%B!MD3:\95@_O(SK
M9^/#R??!NBU(^U" 9'18;WQ<TN7'Q0^/>WU1DK.#-LO?O*.+:WYUH1+CDK%1
M*26I%KPTJ(W49*6V,I/)%QEZ'<+;B?"K28*707N3Y=B%LEJ1*<3*'$WQ6H;:
MJY^+4P(05S<M?<F>[7862$"?4&<P1670 H)5TCNP_,=#/!]46>D6W,9@Z2XP
MLK@6"TYG;IH4!6H027@=;"@!G7 N2<KWIK?J;D3I4CJK,DJKJ*0DR$+2-G@2
MVJL4T"N9O6N1*.T:_+)%Z-4BM4%2H>0L&0218\S"40FFU"7VJ@:\+^RPV=NZ
MKS-MG <H%#-(BA Y<'5>94%0($%4J#Z,#?KFXD-GPR\-#/JO&QB\LNM-QI02
MI5A'Z9..H+T,DB6<([)1VYRMO\C/[$SWA>3+C]:XR50HHS0*Q2^<$%@U11\,
M<G.**2F?7 NLT48WVS*,..99J51VVH&R#H$2Z!1M]"4H;5K$NAU85LH7**6U
M\3Z5E#/DNABWM!F+UBH4;6"%I_Y_ !0.)G_A\) >G\QA= U\_MP=3V9U=:"S
MM,B%#EY<NORE"?'/)O2_AS1*GZ1H?MCYTJ[3EY0.)Y/!Z&U+.H*4<C)XK:*P
M3$8Y(<MY:WP&QV *N@4+NOXPD/F>6_KP\;_Y'>,D[9X\K^S[-W<UK_PPG>]Q
MVZLB+0J_SD!"'[$.L_&G%(JT)K@8%&I"TX+EW3O\W@9^54OP&X5&A244D]E!
M@T%'R2!([:348%JPL.$BK+6PPI8_3&-:%?S*('RJJ78J9%!1>0#2,>IBM?7\
M5ZOP^W>0^;J\\@XE?XL2"\6C\4@E29 R82&,5$RRZ*(LN4/)#^.8VR(LJ:[C
M&LBFJ *4S)3F$B,V)I(JFM0NQ]Q!]D?0DMH6E4UV.H&%*'+T.B59DYB=21E#
MJR#;"BW9VO:S*I EEZT.UDEP+!R5]R*62)B2",EY;%?WTP]BLUA+BQ"2$)D@
MJA*B1*7J4I_&:=FR+I?[Y*?:(JV0DBR"A17Y M+*6)PM.><0* JG;0>@3NA\
M:2FSJ&HQ"8D(ND[*,D:1Q5)LU&16N+S[J@N='\2%^9PRE5"4LAJ*$X%EA\DV
ME)39F9EV#90^'V"<%^F^)%#G(]T?-CP;3Y[PX[-]^"+SH\X&W.M\!!R=+&BZ
MPX\+)ZV=T3I:BY1!A!*C,36=7JE0G,FI@U,KX-2)M>O4?@Y6"TI&: =9&=3"
M.!M):W39BW9U*G38[G3DY4 D@;'*>I-L &(QJ9QG+K<Q2IMT:%<?[PICNY.X
M=X_M+$(H)6I6MPF\8^P)H8(PMF@;3*0?#-LGF8X[,'UWO$2(M5J&3\H 1#%?
M3,"35=&'!*E=H_P_*I@Z>7L-LI/4 I.3L4@"E5RLM;PL*.%KF=D?KB>@0_;]
M$;=@@Q)@2] 1K-71D=>DT*-W&DN[D+U2"O)';6:K@NR8BHR^."S) J"+ ;-S
MUCL9M+;H6X7L&X.I1S.,./UB";X.4'^_9(8KTB/6F78*(F8/7G@9(E.H=*J(
M5@%J!7WM2F/\WDO< HZ*TC%K D@0@DZ !5V6D0*T+).Q0W<G<Z^B.U&.3-/)
M.X*<8E"YAG%6U\%<I=K5-7&_9&ZG3&Z,;A&-4(+A'86"8$Q$8RD)9ZV1&K%=
M$R?:RMTO:3J;#-*,\J4I8YM'E+?&O'6?)L\'B:]!=.LUTQ?5G9NTB:2T+X;%
M00@QIEH7G134DDZV70'4#X^J3O1> W&I%5KT05 &<#*BSZE$C8F"@8!=2+>J
MNG+UV]NJ0%P+&\CF)*5*3-P*0RH&HR,RHBZ%T2J(KY3R7<'V]F-"G .[Q/B6
M()T%Z4WP*0010:9@@CI/8ECMI>>Z@@1?6;5X406-"AE?BQ63=Y P^EK5,J;L
ME:-:?KR#S,I YAX)U\7A5T;([,]UI&3 @0I*Q!PPUQ)=CL!W^/TQ\7N[_;&+
MPZ\6X'1PEG3TX"6B]R9&J;7A3R%BJ_"[4JKT?C>F5<&O%5+E'$R$NGI3)B\A
M&Q3 *+-9A-0J_*X@ ?X=BOOC&=4+T^!]72ZG)6B1$3%'Y<E'#<(7U*(4YT@(
M8O\M58>6%95['71E (:2DT*: '4YH%@@HHB&I!+%M"NVOD_0O8T>TOL%72*(
M3F2E0!(8R23,GMF[J"((5X1N%7172F.N8#NZ9]"U4CL1@PWD !BSP/ U=>$5
MK#I3M@JZ75FL6T*)CR5%FRU&ICH95$S(4;5RQF<'-KH.)6UCL7O?;UE(8[!"
MH4@)*+F0-/OCC" 0A=;MDI,=9'^$KDK+O$JUWJ *%F+(J&N>G04+287B0ZL@
MNU(R\MZUGU6!+)%EH@6 H )$9;R7V>=(143%$&Y7[_H/8C.9C$I2:VN*!BLQ
M&B.\2TJK:&11[8I6[Y.?:HNT$L+*I*0BDPB2M8$UE7-"N2"B\] N:76? -06
MH6.<(.M,"K%(2-I%5[PITH=BDO'4KC&ME1(Z/X@+4T@A%T@^I0#9^H E4'2:
M%4<HK*%;!: 5+I3UH\!)R>2455H( J,I9I>3%\7GY&0"V\&I%7#JQ-IUG0K:
M.$,.LS<!E+3(;*FP) SH1=#MR@CHL-WIR,LZ,EGE=8+*V)",0(1"UMB@;;81
M.AFP;"!U$O?[RV4YU%1(9RD59&5K(0$)DHQ4(ICS"8,_#K9_Q I5BP-3B-$F
MS]K66PV>M8#7=?W#8DUBV?O#"=QV@JF3M]?)6S0R&6]R] 9<$9BBM;$ 1:-J
M=V2'[ [9[12W084H?-!$4$"6B I5CB[Y("'#>;W,MB![I13DC]K,5@79 K,I
MNCAK2$(0!851$E,.'@+_+[<*V5U5JN4#RNFD'%JA3780LHFRJ&"+(U8%"=T/
MUL?58D!U$O<:=*<Z)*$A)R('V>2@0<="T5(NTOAVI6AWZ.YD[E69B[I0\J58
M#N TZP#MM0LE*& *E[[+!;A/:+ZSUK\JZ!9" 43O()H"42H$1\[63 72!6.[
MJK^T%5 K4H9JD5T#/LM,SMM$H!W%5!)+!.%5U$7&=B6*__"HZD3O-1"7PFDA
MT7GG"5*!H'T.4LE@0A;0LN&O%83X2LT&_S%97&1#A<AX)1/()- 0ZN!<%L%"
ML>V">*=\.XA_#O&"P*QMM<RQ@$W)ZVQ1*)-]D";;;J; 2M0B^.HK7WJL>0O>
M.CF@JQ?^=(\_&,[TUWB(LSG&6P+;* *!4S+G_\O>ES<U;FQ]?Q45]SYO)568
M:&EMD^>9*@\P$Q*V8":Y,_^D6MTMK!E9\M4">#[]>TY+\@)FL,& Q/1=$JRU
M=9;?6?KT:1$20S=]/]0#K@-*NZ9CB!9W,LZSXLT9A>"Y8@O^/*+7T:@</58&
M\%&G6<I+5IQD Y%= F/G8&P/L3P=XS#/Q$4)#$^S"03M %HLHO%1% .>I8G(
M^PD_AT\3_"R=T+B(-N<>GT<CT+*3\#RC21Z*["3\D*;\QF"G%]<7P4!.+D4&
M]SYMQXX-[A#*3>)QVR.A81$GL /'X=SU=&X('P)#VF[A_(X(G0YI+JS=.$HB
M1N/S+-I<+>./(AI"%R%W0^YSAW#7\ /=,9D=^#PTB.ZT>(_M%\.M*3"=THDT
MUX!/"ID>FI8RX'E8?Z6[Q/(\2BTS]!V=FSPP=,;^V</7Z89N]-HJAPT3WI5Y
M!,8J[[/_EE$>%7!R3FA6J?]X %. \%FQ1PM1L07(I$_9,CLW)1B?7;K P>;,
M@P"$V,QS #D\1GQB!2;WF"^X'WJ$&3Q\71RD"5^M9KZ3O/3UT*,^#TSF.,1Q
M;.J1P SMD/)0MVWJM-L8# KX;+S^@T@O,CH>HD]0&X=BG+W9[3_.))P)&N_G
M^!( _#YCY0A]5L'WQ#@3X+&BO.R)G&71&/\\"<&& /&+R;P0I=DXS>"NWP3E
M_RV!J2++!S39B\1%NMOO"FHSG1J^<$ P0/MUA]J>#3$Y$;8?VL)JN].P 3Z>
MA"$@'Z#!F<@%YJ[>4R;#U4/Z>QK']%Y6/K5$MT54/,\"$T\LFP64N+;N!U[@
M<=WW@U 7!FMYZ+$)47D7I3F+1"+%Y5RP89+&Z<6D,3:[,!J1'=*K#"_Y8_ <
M<O/'H/5R$U+B^XX5<)N8Q,<^,SHG#J5<%Q"EF&&[Y:8+IJB"L/V1R":741R+
MSE@?1]AV:$)TX%/P. /;]UQ*@'VZ0YA/_):GVKH@&C>-6@>%Q+()LRW;TLV
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MJ,JB((RI&-:6>&:!;C*B68UN-X*?QW2S@\A'#P,#8F;L26_[IL-"'KH!M<S
M[$)90=4O]9Q>U_/+Q631)SN K\T2&I_A;'$I!B*[C)@X.!MT)!\<>D8(P:A!
M/<J(Y^L^]TV#$]LV0T(<CW2?0[+7;3_AV.HV_KW,HIQ'K$-SPX$7@@^F!\0*
M!7:Q\3AS'"?PJ.F 1^UX[><0\&8W$SPJ=FF63<(TPWFMY8WA.\(3@YB.ZWI!
M8/N<F+I'.1,V82QP!<0W5MAIGE0[H= X@J-)1$%UCL75[R++Q:1AT]*[.\([
MGQF$AH)!@&,007W/96":**&N;P$6WMR'2+?:E\I=RVG5K0W-7YA^R"W##G6+
M$.X8GO!\QR4&4- GKDYJNI&&;D[[?" @!EF=;LYF?"#?T]W Y'9@6)2$E.(>
M@.!)VH10BKLFU71S&[JUT'<$8KBKTVU#OJ-EXEX9;A#H=DBHL#S=<FP?%XSC
M$F*SWOS&T)\QJEV?;H;^[,&E"'VB<]^V!,55=Y;GVH!R1AC:-K@-!KDQP]]&
M?%MK<GU3^!9:IFZ&MA<(W%Z)6Q3B<A^(XW N'%<T=",-W5J(;][J^.9M#-^(
MY7C4"6P;NRP:W/!P?V>7<A?IR)RFOMAMZ-9"?/-6QS=O8_AF.+@(WK)\VPZ(
MR<W #T)J!SJX(A8J;T6W!M^>Q9E<GVXKX]L#BV"BZS>9B&69=SZ,QAHXGUD:
M+WX@WK*39A>_F+IN_5)?\4M(6=$+T[1(TD)L:6&6CLY$F&.QK?77)-A++P_-
ML\M/UE')O^Q??O[@?SD9_4F.X?^?O@SCHV^?XY/S/^WC\PMR].WLR]'>I\GQ
MM_W)\?D1'/OKZZ%U''_Z-OYZLO?YZ\F' _+Y_,C\?/Y5/SG_2$[VCO1/W_KF
MT1=V??3EXS<X9GQ^[TU.SMGEY^3WX>=OJ7G\Y?>OG[Z=Q4=[<-^' _UH]'YT
M<G[P[6CT^Y?C+P?&\;<C^VBT;Q\/?/W3W[_GG\]3\].W _O3-_;M^$L\.C:/
M]./1YZ^?OKS[\LG\='5T_C["YYSL_7EU'-7W_.?W83#B\<F7SU^.OL1?X)GF
MR=^?K$_?_C0_C\ZBHP_'<*9_??0WC.4+?/M>W_S/MR/]\/RH.!KHUX?G_7\H
M"X@(@75F0(,>"1VWYX>!Z%F"Z"2T2<AMJBF*?I>B?UX=GG^<4C0$\PRZ'O:H
M8X<]PD*@**=&SP8ZLU GCFDJBMXGH\:\C'+;T5T TIY/J-,C$)?WP':3GN%@
MP:D.;A#5%47OH2B9EU&#,<)#<!!H$!H]W*JWY]ENT L"PG1  M^Q/471>RAJ
M+^(H"X/0-'MZ:/D]XH#"!\ST>]1V3 .DU^745A2]AZ+?YF74 Z+I)D"H;3BL
M1P1X&!!;VSWP/AV?!@X#,% 4O1]']Z<4-</ -+C0>]S4;9!1W>SY>L!ZU-,I
MX\SP?$]I_0HR.M-Z2S@>X;K>\RS/!._) (4WX!^N89HNML;Q V695K!,<[9>
MY]2U#=:S;!>TWN-N+X!CO9";/@]LWW.(DM$59'2F]9CD<$S.>D)0WB/@T?<
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M%N-AF@@M*7%J>EL#08]+Y(]&,T%!?KAXH_WDV=[/%:C8MMYS;7T=X]=VN@Q
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M-KTR4H5,6Z.FH"",Q[A=(X:R<  LS%23OF/LI--T6<G!1-JIRJFZ\;X=[6\
MT.Q":!,0/A1(> 7 &7 .J%9*I8UD>_@TN=?";L-;(]#X'%[TM;+K-&_$%'/X
MU=]S+]^_QD)@O"H#0QYE%:C'] H>!1^>Y^#JP:BT-("HJW(_87SEN'K8=_V3
M;:D86A2"<%\M.+"!J(PQO03G5I*U,<82D78TZ6/5+-.BFD\SK<*]+[4AS0*
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M0NZ7.(4_K7;]F&!_#>T/&!1/1ZLY)@J8'@%,K1C;UML$;!43HT6 3)*TE%5
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M&2:$7.#"-#9[:J[_^L/T=!_Q<5'VDC0!L6#I,(TCIH6TP)7L\]7NU=)E+<U
M%F75G\SV8.E@-9BZVK!VLOH#[)%>.PYU[FXDJFI\>-  GO0^P^Q]SM)M;;>O
M4OA/#7/U5C^M&.'6V_LD>(:K"[)KFX:Q(+N9F%;CR?MP"7B8R22.N-/C1T!^
MAQEL--Q'D2QM!W^WKABI"\OF1?9506Y7!+8?<S')Z)PI%@F$,7%C06]G$63N
MX(Y< =Y0S[2GU2*?3(!'>4UC.K[#0L>QR"X #%F:?($!5.4N*W:@5++P-+*
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M)$X-O/%*U"9&"Y0DJL%SP\0D+*5,30Q6>8T'UMF/:J4*2$@+@OSQY^P*8XJ
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M&-I7B?G,AM2"X^]K[?37D7"W-V9Z^_Y='NZ^F&X\>5'VSG0HS $2W5UBYM!
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M/?K,ALN4RQ2E_'(OUUDDI*"/DEK6?ET\4Y<]L^##.6',[K%2FWB/(ZX).B@
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M.Y<VHT>0'>%)J6,'[0\L"XP"YV=S1),\ #V)<QL.@&OZD<<?7-Z)8+,!LE<
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M*\T2U@-K0HG 18E;<))PH9*@$*]S < U'ST(ZC*$@H.@%O[F ,IQ^4 P-8@
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M@(0RV])/)S>+'V)8C_FC \R9)/ -)[+AX3[F8(I0'?54%E<77C:.?Z<2IZV
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MT^F$Q5(('<3XK\C#^035H]F5$[+7+FP\=B<^,MEQ7/P!("4P)C;M!?@HQ_^
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M?5/PIAX%0>V-K"%W(S@!ZBLEANFH:HJ4]'@E.A=5+9/[C<O:JB?"U3&"%?:
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MD1G[G8"V>-H'0B!!WL=-P"?R:>QXV%#,15$0R[9RI::F4\/GITD(P%;\*#N
M1H^I; ].U:1'T0]<="H3B+/#7*5]Q.F][.M-G"$1I6V3T9G)'K9R>=/W8?*R
MZ$UVI9U>U9R6Y<!))60EYOV?LHK*8DW< <!B2DI,(6Y14RC@_E?N/#RR<;Z%
M.^H/>G#&63,NY-'.2KA8:\/O[?/X2E)_UJY6L-'T6:F-=PLCYDN+N:)<.?[#
MZ^)=FR/><P1)'5$R*7+RQ@I&/<)4M4>,8P)"H*[[0;EC8TF1&6*:"]3VF6?9
MD*24GYO+4J/1  'B_G#''*5R2QG,5>?#M-OTI4=43MX3?&G#E9-YR)AI"5"4
MC)O=QWU6T4\$1.,X3]EJU5IB> 5<.SL*SH[CF6DOT$CV*87G_@;#]SOJDTXY
M?H-P+,GVIKB+> $B0CJQI60G+UZ7?N[+K>)5/>B+"Y,0PTB,TA'!4?09"?#9
M)6)TJ\=Q#B"*/^PZ?.(J:\VG#W!T<R(<,T0R/JDWM6A?HO);3)HC#["(!SRZ
M\:=F))]*]Z]8("Y.N<4QY^^9]>5<D;_5:N,"]GBT7#K08^*_;X[_-DS\=[U#
M4"Z\ #.&04EX<BI\M?K)NKVY.CS$ONW4!W1=W)%*<OV+5+^8JDI[Z'P;TCG!
MLWFY9C1-.I&,WP?$!3H$E>3D_>#LQ\VYTJJT$X'*%?.N45?WB"OC '$J-W;T
M$,L>-["6$V7EZ-NDN8=:*[%>#&!ZN:[Q6H3[911@"+K+.J(F)*MVCHFYJG9.
M-Q$G4G_B?^N?#LN)VI0_5DI7^MC&<SV3V=^BF<IH(ODZ"GMP^PM'F<>IF2%(
M2O[//A\WZM:[[T!9/V2%AW[Q/J82/M0V9P;P'']4HB.:JHCB@QY &;<_G:BA
MGH*"*=QN(?:CGT!<,=QR:!^^$?KCD6@ B8!@(YQQ+">$/A$<4!:6K63)4: <
MLFWJTF<,%XRO:(G?%;<@UY%5<./GYS_[1OM[T>(0W6V\P\+*@ HUJJ!!,LIA
M[ 00#!/'AP1W2(Y'$T,\)O@/+N?BZW'$1?X(&8>X(#?.2%TYQE$SM&<3@8O8
M_2P;V'6 PYY2(4$Q(U36Z@6VSSK"L(6C@3"Y28I%'/9K=9)IT,3WB?>@:F<"
M#!J59$S9*:6#1V-6E1 _-21:K,>G PP9(JP/HDX0DCB6CH!=164P6N;R0$@W
MRIV\-I$.]NU"&9NQI.#C8KY9U*V_DMG.+/,H[61K9-WA":R\.9WZ(C;*M9/C
M6J.Y6E_$VE'YI%9K'%=SF0QT7*X<'1U6<QD[5(>'BW_>TA?Q9(6N:K5U=E63
MCU]O"XN,O<_J\,_)2?;R_ROV@+KP2FKMP/H7JNT[Z>9(3-;_S&Z_\+9&)*LT
M3]M8\Q)U@JD64M7YG4NJV^]<LFS+NQMIM#.?JSZ$+P)UE33172#O1#N3.1_6
MB/0Q%+@EX2SRYZ!?,C9#*YI&44 M,^'/(X#?^7+\NBA=!'+*YB+%).>65<:R
MI*Z4#_]NE:S:[";_>6B,KOAG.<(752_<LR&#._"',^YU?/:;Y,O22U&V".3;
MA!YX&]&,M.>@9HLJ[6<7I2O2YZ%HF:43&B@$\7[>/NM,LH))>J-<04D_@O\9
MNYZ'I-_Q ?-)?_9-2QO[I"/M<A?TO3+IS5C0C4G/1]!/(X<&W&..L>C+T:Y-
M':[3);[HDGXL);U:,38])U&_IBY_AHWE&QK8/9.^ 4G?*YN^!4G?)Z-^>=OZ
MUM#9,&E(L[LOHNN&ZK(4Z$R]@@F[ O GQ@.?!W73_?UUME :DB[NAZ\SV8HI
MZ\:PYT/>SZ<WHNEHTHW[W?VW2K-:>Z^SN=*0CG((J,Y$*YC<'\FXF['Q^1@J
M'&'[3DZPS5G4=\[(;T+4]\K$BUFP0M9G3VXS-OZ-%]%;ZY2&!.6]=EPY$<4L
M8.5KU8:Q\OJ)_EY9^;JT\AL,Q>V3E?^!76PN;G[H;*LT))LQ\&O/K!%2?FP"
M[KEDTG]IW96J.ALE#8EF+/G:+;G)GLN178G/>)1S#&GG#/GWR.9^TLE%3[(5
M3,P;<>C->..+*N8[9\O;E+I<:Z(54\A-VEQ.UW+12*;$KFE(.K!T6V?[I"']
MBD&X@LG\?[OAIZ:QZ;E)^Q?J8?]=G:V4AL0K -4*)N?*MC>-:<^#NM=,M).S
MSKAH?WW-;)]C!UAFNS3505%GNZ4A5<\9\7B?Z4RU@FF!FM0"=7.-SZ4)P]VO
M4J56T]EJZ4@UX@ZIZ^;<\6.OC/UA[*T[-L9^_=2]O;\K50\K.<OYSEESO+T/
MB1?J3+:"R?D5?[(<'G62IL.J$7&(C<%5=V!CY]=.=C7]1F>#I2/5Q. :G8E6
M,.F_AK5-M!P'Z<=VY%N0_E7,OWK@%)T+KAHF1MF\DS-L=$JT7TC[(A!83H I
M+$4+IF(08,P?;C!7NWP03>HS]=;/-G# 3!VK'FH[=<P,3,CZ?3,P8:&0[/S
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MJ,VZS%8/]'@(_W>PE#WL44N.1\.WX&>C <[=PPE2S+/="-E!?,K!(6B^1?I
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MSXJD"#=M@)Q6J": B;YEE2C?;<FWMF^L(OJ$ <=>*6(@?\)'020-Q!(V3#_
M3?B1%VZT:J9T%TD;_-XX88$BES(B(0%I<"0J%D*4;Y=!'] [RL<H3((^F1LD
M+WC[GZ!\9D'H:S<OJW8\WJV<";=D=FKH3MH]5EG:"_XL,@X9N)4O*):1L60A
MX''<(R(QA:?7DHL!)F%?OX8="VB#:SQ'86?2>"J6(DW9$417'\L #(:T<]!A
MO"QOTC<I=DV!UBQW*EI3'1'NWX-V]Y@O_Z4 SH9A>A/FL-A_>4@G)0.L?/U
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MA16]R<D3YW8=^FMGFX9)&N8[)\P</_+@!(%+K]YX.U@@=W+OLW#"&![P?!^
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M![6@[X_F[G1X1,6W!=LELH<S=_VV53?I .BNW.'TRIVU.,6R T"\'$9R=C+
MZAD/8A;C\=B=C-O4::H#8'L8>[".GY-695FH/JPJ:SSHN_WI$3$,"V'KL&P3
M8-MJ%'0:J-9AV2)-P1H2+;HZ:TA8AZ5E#VV0 !VXR+;J)AT G7586D9RR3+
MZAG68=DN]M!&QX_\4KZODXZA#CHTSP#J<W?8[[O]V1$<P]Z =8AVR;G45J.C
MTT"U#M$6:2+64&G1U5E#Q3I$+7MH@P3HP$6V53?I .BL0]0RDE/7"W?9GFR/
M'G(7,+L R39Z4[L.TSL8S_/<6T0"_AN$-S__._Q+0S7)PCQ,XA>IB+P\O!$O
M;\,@7[\8]/M_>;F6VQWVIA,X@O'-#\V+> N 6)&C8XE@V#_\S+Z+J@:^(X]=
MA94)U>LT]**7U5N(PE@\D\<:#&E3PX$&%P''_/<Z+;%O)9XM4N%]?N8M8;<O
MO.C6VV7(4]=IY6#W 8U/^?._+]+G/S>]^4X8;;QT%<8*1:\8Z>ANU3/R%X2F
M7I$GZA%&4_I$XCE +O*VF7BA_K!')O3W, [@W2_Z\"XE3L*8X$COE0><CWMC
M^A\=4\HYN24)@AZ#0)%X]4MXO#^[NIK?\9,[G[_SRV%O.!Z,9U<G67S:&\PG
M_?%I%A_WIH/9\.K\%^]20*@#HJ"# 9\.0'7N3B=],(\>,E?$0OCL S8=@6U;
M_2+=#BK8F(WUI5A_>JM])1T EHW96/9PR3[SMNHF'0"=C=E81G+),L#J&1T/
MNW0 ;-U/8N\ D*W/\C2-KMW!8.K.)T>8%A;$UFG9,MBVU3#HME?-.BW;HRU8
M8Z)%5V>-">NTM.RA#1*@ Q?95MVD Z"S3DO+2"Y9!E@]PSHM6\D>K+_G?L"V
M8';IF4 2$RH'[GSRY&,-SQJJP^<#H/W^:-1"M:KKL/WM^?414&V5+ZQ3^[3B
MZ=1Q- O)!XBG\7SD3F8M&:U])E =/A].3RF>+FB*\5=*HPN"D 7/\>"QLO<Q
M9.]S:QX^8NY*?]QW9U,K@+LD@"\V\-]!X[ ]TL<"Z_%$]7</\CSA3^_N;R*[
M7^"5C^">JOTS!GUYK\7V@?A6O<.[;KO$DZO>I(8I4WAVKR-)#75AY[#%?_N7
MV7 X00%8;!^Y3<KA#1-X&CJF5(7Q$VUFUKR77[YLP]3#YC-.X.7"29;.+T6:
M; 5LRHL#AP)M(A/.%KZ-\\SQ4N$ =/TB@@\"Q\N<8=_9"2_-G&6:;)Q\+1SX
M6Q2*+'< T;9I<A-FL+X7.<L0=K#B%^6)<[L._;6S3<,D#?.=$V:.'WEP@,"E
M5P<)/)\[N?=9.&$,O_=\'T"3.\"K1(Q+9O V+Z<M):FS\7;.0CC>C1=&U-$E
MC'$WL/<_BS3,@M#'8V:]:M.8>KL8V:YE.#V,[=\7>SX4BS^%GR, _62SC4(O
M]H5S&^9K@CVH79L,KQ'_DHIL"[\-;P LJU2(#5ZAZR1%ZA!CSG"55/@"?Y$F
M.R^">]AZ._J= Z<2*?TX"D&ARV"C]!K\1'SQHR+#Q_B[!.X_WVV1\*(=WU#@
M+.%6<!M1N!1J2PJ/_ 0(%;$A*P ) G$CHF1+[^TY;^ YSP%NY1<9WK,^3IA]
M!@S,LL0/"?MH.[PBH0P@&Z"3R+UT)P_H.ID0@!91<BO/0ZS@R<F/;I/_BN]Z
M$>; GORF^_TU%QMG<-US?H?3.F\\/P?8]K['=AM9%P!O\/(@"7U_BMF'\;T2
MXX>?WVWB\'I1,Y+N90_?DQ<,)K1OH$2]]^GX)5))ZFU% 1(0""(/%TD ! VL
M&DAQ \00QD"VJ)C18[][.3_GTE_?)D4FY$)(3?C9*^#1GT4,]SZ>#>%W0&%!
M ?PF]O(B)5I/MGFX@4T"UUX6^,&ZV)#PH+>#&$ ^[,7AQHN M/\0SMI#9L-,
M)U#4"^OF@A@TWP(0/1_,7 @WM1'Y.@DR!U<=]1V2"$#RE;,AK_@4A\@A/N2P
M/GRY*:(\W()0T _ K^"R5NNDR*7(<UG:T6O@W+'G_(C,(Q,1[ S6\CUD@5&8
MX5]8N#C<.XSXRT_T()Z.CS"YTJQI"VS:)RF;.5O@C+A)6& X-K9SFZ11<!L&
MHN=\-/@DKEEY/KF-X?6+G5.P,!9?MKP]8.4"I3EN)[\5 M;O#V>T !BK8V:0
M7IK'(N4G:>OP%-PZG>7=VX_RM;B:\-<QH.IJAS]9"7@*Q78,;#LR[L254EP*
M7W@VS"/>#%H .0O^O4L^4@@/]X3P54EW32W@3K901[K(]7NC27\VG7YE%[E)
M[VHTG8R_NFG9/1W-!K/!<'2:Q6>]_M5X.IR<9/%!;]"_FLY/U>CMA& 9]V;#
MV7AZ;%O 1K-X,'N(-TL+5L#4ASL?FOV&Q^0^R"^5 ^(^KZ+\N79/'/C]$>Z+
M4NLP=(P3^"\:=916>!!.Z)>HX^+\*U!Q.&@W*K;/55;1G;X+QIWC/3\>RWFR
M8%R*#H2$]54PRN%M\9.APPFBJ9><>/=QMR4?S/N:H=6E&%9'0/VI]Z'GO&>3
MY[>D9^%\2C@;#NS7 '(+[%-5W!@^= OD$P%9,8UBLQ"IA?*)H+S',B@VV #N
M>QL43;\M;V:Q%.,+RIMYE;Q]0 ^=B87M V [<Z?]D3N>32R$3Y9,]QS^/^R/
M!J=*H]L'Z#DSX4^GS4F\*& .W<%DZ,YF?0O31X/IY/D(R;VQQ4+;T\>>6B/L
MP'6>F-^<.?2&[FATY8Z&<PM$RU%.(R\Z<(&MTEDZ *^A>P5&R6@XLF"S?.)B
MV;YM<_;UE.#.AB/W:GY:N^;<@7AA[.3LY,%)FYV=&["NW.$09TR>N"72N8'M
M:9C$2?W,YU"D.'='LYD['#VYQGR^(+T+L]NA0W0:O!VLV>[4/BWS?=)V&=.A
MV[\ZK9?SHF#Z--SWD2)370#HU[:L>E((M7QGIVC4]%A$W1$T_)2=-M7RTN Y
M<^?]J3LX=2??"X-JAW7_CD 8Q-'1L&T;X+JVU;:++?FE:O[0173&_H.=$FUG
M /.Y.YY.W-FD(U;7F4!]_'PPP6S6<;M-LC.!]C>)R=:!LON;O[OIW3Z/.*Y3
MR#;)J./)BU1$'G;=DFTY!OW^7U25\GC8FV(?.^.;'YH7\19PO"+'S'DZ</_P
M,P<W_$!]IHK=)AU<IZ$7O:S234,CI>&P"ASSW^NTY"<K\6R1"N_S,V\)NWWA
M1;?>+L/+6:>5@]T'M,/7\N V+M2QHBU]7$:]\7#0GXR^NH]+?S*=]T<GZ2DR
MZEV-Y^/)\!2+#_N]J_E@VC]-JQ58?'K5GYQF\5."93#N#:>3\=%-8FP?E]KO
M6]?'!=M_&?W5;$.7,VKTT3[UL]+0Q;9R:1'7^9ZM7&P3EZ[1\7X3%^O2/G7[
M%@OA)VG<8L%\TI8M%KRG;=9BX?M$;5I./G'KDK*S9+BK"R&7#D!SYO9'?;<_
M/Z('BX7J\5F9P^?#T?X<]E9&JCH 3FYU;T'Y*.7-P^G O7KZG*TSABE0^CZM
M6S'_;4 ]X43-2P+CS!T/)NY@:HNS3DON+3>?N@#7MO8<Z#10)^YT-'6G_=/*
M^XL%;^=$?T?@^JK]TK\CD)RYD_G0O1J/NZ$ = 6J7*0QZEL#JN62_[(@">)^
M<N7.^D-KWC\BK0\&^[3>9B'?!:AV0,)W 8QS=]P?NX-A1_SW70 I.N_GIQ3N
M%VLMV;XKE]LCH OXV8&P<A? .'<G8_AG].3]4\X7I,TZJ-7HGU0.V7XT'9$U
M'4%#F\GTV)W0\)])1\1.1\!Z:LESR=FBUAZR,JKE*&IEU"/+J,$4YQ+9:%R7
M9)2UCMII@[1W9U;R/(KD>6NESZ.F@LRN)N[XZLF#PV<-U<GS&<J>H;6/VB*)
MVM#WLD-;;;.LZ@*6ODHV71%470#G'),5P4SJB!NO"R =/)]V8 A\%R!I;2-K
M&[4 #3N0/-<12.+PLKX[[<KXG(Y =<+E[]TRBKH V%\^=0FB'0'JT)T.1O#/
M:?TBEPSA9G[09D6@"U#M@!;0!3#.W5D?C<Z.N$6[ -)3RW\;D&NG:=?>G5E9
M<Q%Y(%T )9B<\[$[FEIY\XAY-<\'5];@;(_L^>ZI?UW99YOE$B%*]^=8=<!,
M.A-(S]WY#&>1=T2RG0G43R[\6C<.K8L2L75 [/[F[QZ()Z>>X2Y&\%!M<%I?
M8E*Q?:!N4,6:N_"KQ,RKWJ2&FSBG:6\470V:L'/88ME"O-@^\GR\PQLF\#2,
MRJOR]2?:S*QY+T:K]<#+:<0(]PF&37EQX%!3(9$)9TL][S/'2X4#T/6+R,/!
M0E[F#/O.3GAIYBS39./D:^' WZ)09+D3)_$V36["#-;W(F<9P@Y6_*(\<6[7
MH;]VMFF8I&&^<\+,\2,/#A"X].H@@>=S)_<^"R>,X?>>[P-H<@?(1\2X9 9O
M\W+:4I(Z&V_G+(3CW7AA1)/\PAAW WO_TQB'D)5C/0[@ND+NX3Z;/#6R\%_Q
M72_"'/#7OQ_=?_CYOT4*P VS@^<RQP\.IT]_JLJ>!Q/<\[LBA>O\9Q'RQ$M$
M.W4,FH_FY\E"I(!:@YE#&!3 "XK,N0WSM>,YVR3-E\#P$GQPD\#] R+$SLQ9
M%E&T>[:$HP!N9NL$$!967R5>Y,*Z?E0@$W1^?_^/R60,6.:\7WN 'T,7,.U&
M1$Z>"B_?X&R')2#4JW?O7[L22V%?6R_-8Y'"PK0+V"\@-:Z0;KR7A+&OWO_Z
M;#PV%AXX'D ]R0  SO7PVDF%+[8Y+.W%N;=*XC#C-Y7OA?,P)\\+.%=V^/6O
MDO0& ,*O]T5!/"_KE6"$#< ^;I,T"FX!?)* JZ"#0Z?.:-)W5BGL");65 ZG
MD5\Z6\&SH[SM%C"2> 7L"Q$HQH_I9U=]AV@S!;+OG82SU<>0$GDV8!8SUYKJ
M?(=4&XP/B[6GIOR[Z?R7S39*=D(\@-"-<TY:<<R&8UUGB(EOQ"(MO'3G#( 8
M@>SG)KTFP"UB<1OMF&<@#2@TYXO.BD46!B$\#P0C /5OY"#WP>"*_X",X5D.
MFW.$ J.+[[U=@\R:34F&A/%-$MW X@&\PL_A=<"*,C\$<(;+T ?JS4"R 362
M=!+ ,)(M$:T'DN4&&)FX7[AT"^5^C6] C .#^C4&-K7Q*O.$6BUF>/]OPMB+
M?6 <S-! &TCA3O51'&^1%#G*%>"7I=Z \@@P[E8 4H&F AK&[>UM#[1)6*3G
M)YN>\X< ;>.S./R,GVP!&XC%PJ?7<5S 'GX7R'SQIV]@!\Z@_^SOKO-_ .O!
MZ@9DXZ\S\_O_XSI^D::(8VGMV]FSO].A/,# 8$-,&U2D?)V V%&_!7T+L!FN
M;UFD(&O6R."+-"N U^.//_ @.4DIHQ^]G_"W@\F/P4^X<]3D?OGB@V!=@?3R
M<]3UL@2AEL$;O RDWP*VO4T1_7V" LUT1@H4$:P-\A&%$OP&-^)D!9 . %X@
M)R<AYAI[<T+<DTMOI2EAL#M0VY"HZ)QZ)Z^2S2;,4/VCQS_\\JH'Z.F@?9/3
MAY(!P,;$39@4F7Q_ )M>@<"5VFZ&$S$WI; CW @2O^#/2,;B7FC]ZWBGO\/U
MZ3Q2WPSC; N'):TU5X^@O3&8O@2I72PB8AU+$-VQ#W>3 ,.!'P[Z?>>-\P$D
MO\B=WWYQG3^\; W,+L<CO'X%/!#;_^ )&U8-T5$3PX-P:N!*F<+13/B]57+3
M<SZ2WJLQF'\E6'M'I1H7(!T)T "T)9^I 92&W19P,8P_9ZR#XXM-@O&!Y#R@
MLP!98X5(XD#JVY6-JJ^!ONJO156=E!K&M3"3YD'/9#8.S5/G!W!M,$SD_4D$
MO1_6\IJ2A=SX8H?V"QDB<@&$WJS??P9_?-8?C?H-3#P,_O</X?_K_[^KR0_&
MQW>.AC]J;GQ5"EQMVS.'?-Z;]J=7_>'7S2&?]V;3J]GH)&/(9U>]P7 TN)I^
MRTCL[Q#(0D_$MWCFGFI,]:\??WDK9<)UJV9@=@6 O__ZX>_.F^M7']_]_F$_
M5>^@JZVB/XWWM??O[HMH4+! SH !&T7)+?)3U*) S&\VJ,B#Q>ZGX58QZRS9
M",6TX6T[)PVSSQD)4S!?E3A9%&@K9V#'_M^D0 .^B #G0&J18>^@1(?]LE>'
M%X 'Q8T7%2 5I*6@UC M"'RK^KS4R[39@)J[^4:PI!.4=? M: 4D>/9T1S[?
M0DBY%V92[0)M0:HBH.7P'E'T;=%ZB-&H^!PGMS$*-- [T?9'%Q: 02IZ$4).
M;)QPHU4EV@V*L7"S]<*T"JB'R9T&M-LF[(-Y0:(VO%$2 !24OZBIW.-A;XHH
M:'SS0_,BWB)+HB(7+R7U]P\_LQ]Y>FP,K_L,YLU6PG!4A9/Y[W5:LKF5>+8
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M*0FMU[LL!"RE]V]A)^S(0_^\%_M:53'NLN1;:WACG2D!-N0H\,4"* -^G@H
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MP+YC#,54$!"6*/DI)!I2= @#Z? ZI%$#]]6.."]EB5O%M#&0MB):@B1<"AE
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M0RYE!&,1-,!-TVO]!+4]JZHTX+X!VL0"@V%@MRHG$YU BA(E&:G (;]')-=
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MY->$76B%O\R#,$PD[BN=H::OC*-]2YG7SQB:W/L3ZYL+SJB)O%O@=NG&S+2
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MPGY1'#2,4%W 'YF]MF8_WLC?!4_P3QON2HODIK(,,#7B;_" _.;$3A-8(/_
MV6DN[XAU[D+).5BW]U5WR0U?XL4O'U(VY0?3YJ^%*@@R*P(^3L#?0YRJ18-O
M8)<?CV$3YY%)A9@DEC^3SCWF*#FP;J'V2.1N(_RF3Q&:_Q-ZS\Z3:BIR*]T?
M*"NMK'3KC4QAI2UEI+>@WQ?>;>:S\[+*Z([G<)($F,U+M!,Z\:=YAB(I5<7D
MZNKP;"U!>'L:+L0;T"B?H\$K<33F&WBUMSZ[DWT>.!&"M]/S#)>$1YTP;R2
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M!I:/O^,<D%].$$MQY@ES^6V140)N]D,X;/-<P6\2L[&JAJB^H93/LEZ#[B&
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M8)@%[J+C*#CIEK'--/3^+EW-JEJW(8S\"*Z@YJ5I[-]FJ7<;,"V-CNWTG7T
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MS1-DSR2NO-AC1%O-EB7F3+WXS@^E#O:X.) ,+'R#!,C+TNB-^ ,7(/J+B#>
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MUQ1V-H@!Y. !BH0+"'J<C31DBV.@,!J +_EX28C(VS[%SOAG8"5WGO'^]Z_
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M>90-"OD)2?[",@=)'5VI*'1"B>(48S]XZ=>":.7DS!_>T:[R4IA@SE>5L^/
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M2+%2E<.(%[T_]:L*:_'_L_>F36TEV;KP7U%P^[S1':'ERGFH.I<("J@Z]+7
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ME\ D<LGTD1R<0%[[0!0UB6?P)I5398$5Q\5&:/02'!=%H^>JT:T)C2;:((/
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M6Y=&/0V5@Z1&_3 87KDUZI%;N@;P5%.3Y*#[*0DSU^V.G*R'O>Y-*G$!I=E
MB4R:)-0;+GCDP#E*A(1: 2J8"($ZA(U6.G',K6U,FUKKDDOV9'1[F;'4HMMS
MU>VQL9&DQ0QQ243:4F!!BV1L8 <(>V40(4AJ6QD;8I[-_XIJUUNUYV!4%/U=
MH/Z.#0;DL3(J2M VEZ;[X,%B2G.:% E!2A:UV-H68JJZ]!+I>* !<14/+2&.
MA;L[EFM0C,1;BFD?A%-TTH9 @GNG$[' "9& <:[ **E :L\XE<X'0;>VF6J2
M[R1O%:_F4U/SY=H61<T?I^83K?RXBCI&!DI& DP+"8HJ#)I8K1&BR9Z0E:N
M?<>>*&K^U-1\F2F81<T?J^9CJT-%KZQ@%B*F.4QA,!B!,4@?J98A.,)1-3-
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M%^WAY7< IHS]6LVXGZ7Y?%[G8,I@V7E,9>Q3W?;!3C6!OM[Y;$OS0:[32]=
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MNF%8Z@V6$N(7E#H9M3'6<F:(UM[D-FM11$](%+A*4I+724IR#HTR[TYL'J4
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M"-HDY$+8@**(@;#>&R4Y"Y9O;1/<Q$PUA>!K$EM:/% ^2,-7K\__N%=2I';
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MIE10PC33DGMJ+!,8U(%<Y\.LT::H /NE LQE9+Q]]>GDJ$.),1$GC((S%O&
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MF1:9/@R9[JI'XE?;[8]#'S-EY21-%9BBM2RGM8AKS@G:,1*3(!Q!7"8/_YB
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M">6<;] YO^ ON#P^ZJ20)4DBPB2'):1(R"1!D,2!&1L$]=(N<]*7U(H?*N$
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MJ&B&M D,4>-]("9*Z_G!(6>F+409V_EPD+Z%B$D!^<I /F^7O/O4229A'UU
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M.X8<#^['46MX:JOY_-1<91?_>]$=7;;L)UN%X2+K?)N2BL]XGX+&K\<[Y>T
M=L_OW=%I3AN %?QE4+W)F^9G"[K;D\'9>>P/;;[^HL=]][RGHXY1AE(%=EI@
MPH.=Q@5R(%=$9="$F81CMM-86\F[QE:6$-+^T\%&_3.%#C8]#NJHDSSG,:F$
M&"4:<8<Q,B!<1#A(V-GHI;0'AP2W<1G\5OA@%?Z< OHMCX,ZZL3 E4U,(I&;
MC'"N+3*!)40"M4D&&;G%!X?&W#7AO@21[X!6O7?!$CJ?5*"6!H;[8K, ,;V^
M$FLN+#X[&_1KKW-AIN^>[W3441P[T"R!E&C@8)U8B9QT\"?A3$:GF;*Y:PBE
M;2WU:O21$D)J.+RW88,4>*]ARM-1!PMFN0L!*9;3V*PSR&KJ$>@<C@0O&,,*
MX-TV4A9P/PAP;S1 7,"]ODE/1QV;O*<\$.0B5OG$M@B4+X*,(QB;Q/,(J.Q9
M-/BNXI02BEE!*&:VQ6_MH%X"*7MOE)36K#_<)N0#??'7NPX),7(6 R(I-S9+
M$2.G?4 )US)-1 0-S(;;V!0GZ7Y"O]%U=P7T*VT; J#_\JKC0 5-."1DJ&"(
M>Z.1YE$BET0>_118=*24W!7H;[?DKD!_I<U$,O1]Q]B(HT@>1<+S&!4-1HP,
ML$]TD(E0GTS@6Z^V<RGRO0F4S'</>?*?UZU_CSN'K"M<<G/M=IRC-FR9S#=7
MG4CN[> )_ BL"OSQ']N[B*_S_4[D>+TF^+)0U/<W V'P&ZR3',/6!9$[ L1<
M;Q.1LY$A&K3FV#O+N#\XI"M*XKHGVVS5C[IWH&Z.S5&0OI7>'X#T]Y\Z@C 5
M#?-@>00P1(RS2#M+4-+1@)X2'6;K&?M4,-_L@WP3L9."_*UT_<C(_])17##F
MB$5"485X4A&9$ W*78N5SY3O:*ZY$W@+F5JKB:@PV4@8YNX?'@[ W +D8S?$
MT'*7K;]?#.%!M_^/5IKN]9:]:G+3Q(Z&DRJ[_'NPJJWAH-<-K;P8NT"%#0VV
MP-9X COCY61C_'SY#G;%\WYI>[2*&=RS3##I@[;2*&2)DH@S*9"5.J*(.75<
M4T<HV#>,ZK;0]ZHX+N[7?2.(#2>1#6'=X%&ABF90Q2RK+&(&5I%7*'"9$(_)
M(T-LGD!E, V> =_S@T/5%O1F:Z$2G2T<L4)[JG!$HSCBW9PZP20!!0*Y:"T"
MQ3 @('Z'"#:,6VH",RJW)S)W9G#L0M%+ ]/1GJ44_;CJ_[,_M?WWL57946R-
M'P]; ,UL<*TU/VW)5-L'0WPK,)^NB&^1W<92/TG/)C)_#2(_Z6?"R___[+\7
MW8] :77]WW!4=?THAOS"43\L/C'WSD*#R[F5OLQGLYT\?=71E@;)E4%1I-Q+
M.GAD,?8H6DQ2\#8Y'0X.Z2U]G$H*_K=Y84>HH3EQI4(33:*)XSF:\!WC%(@9
MS"CE0YW.KY .V"$,LF+66QST6O+?"E_L,%]L* &N\$43^&*6-'?R]H^.D5A;
MDI6)J#SBGA!D+;$H!.J=Y5HKX[>=-+?/ [ARR*K;]U7,%3]_!TS5C_X!SXTC
M6;E/??T@SC9]$V-6.[#4#8U,_1#_O8Q5=Q">3S;0T\GV 8+M7>35GV?:,?L6
MPES.'<7FHUO<"RVYB(@P[A#'3"+#+$7<!::]8I3'D#NPM)DJP:W"))MN@U"8
MI.%,,@M^.4JY 9T*:6D(J%U"(*NX120%FH*Q!)2RW%+AMGXIA4CVAD@:'^<J
ME-)P2IG%R@BW1D0;$;,^@$K" S*6!I0BC\X8*KF)!X=*MZ6ZJTW++@3+MHK;
MO-';-^RRVEBKKM P,>!&+1??=_O]G'<X2*W+:*O23V[UBE8BUE,OB8E><\R3
MD\*&%*SSV#N:5.?Y=O6KPFW+<1M?,+Q2HLR2B)+V$7%.!#*!PY]!FJ2H$CJP
M>@Z9I+@XM1\,YN%X(U;'&(F0/&!ML2#PKPHF<4HXJS'_8]VG"N8WB_F9B128
M38HPCYC$%G$M'+()1Q1<HE9+;**68"+IMA*T8/[!8-YQS[Q,UAO%N&;.!L^Y
ME9(*Z@VEM,:\*)C?(<S/;!B%07=+5B(<)=@PQ!!DB0 ;AF/"HE=:&WUP:%2;
MTWOY14HP:HUF382GOV+0;'I]ORMDO^W5_C]?/9YH ]/&YY>P.3MVB8-#*TYQ
M)(Y(*;BPR1$"IRBHCXY8I[BO#XXMAO+*P?'=_?Z..DQA1U("%5'+7&VO*=(R
M)'@4I; X12K@X"#$M)5>I86X.8]ZH=1"J4VCU.)SVSM*G=G?2E+"<-+(XEQ[
MPXA&FEJ:L\X= _,3#'"W!I];8=3"J ^748M'<^\8=6X8N]"*>"<0YCSWIK4N
M5S,JY&1D!G/BN7?+>#2W%Z9=@V=1K6F6U\7Y^7ATL>VU0G?H>X/A154WUZ_]
M&*DW^-3J]L?H@75>O\MXCKP8D%<87.09[,L5%C38H5U69Q=69U\=HVMBD2=U
M4ZD\'SU<5#F18W0::\?GXV:KN.5JRM4L?34E^^L.-G@."GN.A]2,L,+0QP^>
M1=M>EG69BM\9[F[.?FEHX=%T&[^$7?PBEN3;)4LI+^?C#SH%1CDV*#J6YYXF
M@9P0'DF"I<&84K#I<SZ_(#>;634S5Z7P6.&QW2A[*CSVHSPV<_H+'A.CP:,D
MC4.<BHA 9AQI+!)/R4E'35V7Q%99EU1XK/!8,WELDX-N"X_]*(_-)1)R);CF
MN5; 8,1SD;9)PB*1J$G$ YOIM 2/[:N[;$T >VL_P]>LV#I>J?=CVRO4R+!J
M\S;2-N9CS>C8#\YBO94S(Q<Z_NX&AD<=(B*5S&M$N4^()PUT'(A'-O?0D%9Q
MS/'!(>,W1XR71))":@^7U%9@1A=26T^[1= Q"0->LPHE;P/B*A)DO+<HT>A8
MT%IZ"J1&A"JD5DBMD-HJ;>I":NOI"7G4<3HJ1:1!!@<#FAK0FS-)(@8V= Q*
M14G!<-Z:U;RE0/(FDM.&_C2&BUZ=F@8+B^KTM&[_8QSFV7UU$=YW#C#;\:2G
M\OL[\_N[YR=KX,R--Z.!_]#J#H<7,63O,8#]OQ?=83?3;+O5C_4XCOPR<$&$
M91Z.%L=O7-W2X;]<]<_#VV=S%/6NJ'>-=<3=IYEXC9+G-4B>UCF9XVYS]8#;
MHQE@2L7"DMH@F??;T8!9BB*"(HC!Q-6:(6N(0H92C35-R7NZCFD"Q<PM/+CK
M/+BA(2R%!]?&@S-7GW<:&TT<DL1[Q+F@R&J?XQ>,.859[@I>>+#PX(/AP0TW
M+KYW#DUAP[6QX9R/,"6*G24HJAS-5=X@YZU!G@FBF8F1)7-PJ%2;L9L!W:9T
M&MZ=YGAC?T#V_WVR567[HU85?>Q^G'@'JGAN+[,/,;L%_M/]D-V#_<$(?GG\
M-NMZL12IE*3(G;'P>^_[X7'N.3"Z?#W9Z-W^Z^DN'Z07L+E?7VWMPN3+,3F=
MM^^#3TH'!E8]U19Q[R72BA"$"1%86A:IV[EI@87;"K<UUFHOW+9F;IO9[,PH
M*B112.+<,YYZ#.9Z#$BFW%0G<4,*MQ5N>TC<M@E#O!#<F@EN9H9+FH++!&>5
M$=DIJ9 6BB..:7(N1LE<;B?5IOA>_?F:$KO?'</\R/LJQ^ASD@[L[>JR=7Y1
M^5,[O)F5TY1%W/:2%?=JPXWQKY/Z9+<_GV[VE].]7DA\.1)?&"EKL# T.(RB
M4Q1QC2,RE'/$."=,JN"%3 >'M UO*W&E0GR%^#;:8J(0WXJ);RZD+HE6EEGD
MA%*(>\F18<HC:IR/5'DB?.[8W\:XU,\4XBO$MX;ZF<)N*V:WN?X3>;J,"AKQ
MD*>0R*2!Y[!"-&GBO!!28%#K)+\YB;=1=32[8XN_ZU<1KOD+F./O;;?? @@=
M_?)F4C^374^K-,F++_7!^U)7WFYBMH%_A?W[VV X/.D_G^W>PL;+L?'"^&"B
M.*'$4$2"$T#)EB#-&4>@=$H;\]GI\,$A+RW-"G/M/W.MO*=$8:Y5,]?,2M;6
MAQB\04RYB+A0#CD<<YM9[0V1+D5MP4KFO%!7H:[=I*X-IY(/83'@T1(YY87?
M5LUO,SO9"&L,T0K!=O' ;UXBFZ)'429+0^ZHC>N^V03?#'_<DDG^SU'.*I@K
MA)[NZC-;O>_VIX-3KN_Y3=1\US_UN#N"G>07J[YI7?7]_][$V,K9$:V_DW_4
MB=TACFRWERW9/&VDBA^[0[CM1S>*O:=W,<< /N9>HC]M[:X)ON]MY[L&T0_.
MX,(N9ZGKHT&^Z6$N;^_7X]ULGCP]Z7^1FV6,X(D:?K>L1XW"#NXP+@_NM4X'
M7Z^77_@^86[[OKE5)GRVS%_YMCM>O/'MYX-QR<KC*O;LJ/LQ_O2I&T:GXV8!
MD[7D])$2\,MSKQS<_B76P6I>C.)/DR,%?_TS7UVFE>V?HPI$.;=K#-S"+5M$
M\&LM#.;^/:UF9^?[B!PP]0=@$+C:Q[;WR5X.L\!.JX4;NVO1OM$\85&(VP/2
M-[M(C%?M7;\7A\.:.B9'*%#(?R^Z%?S2 )ZM/G6'L0W/I5C%OH=GNYEHNKEL
MY'Q0C3($<W(DQ3_]UGUO^Z%=_T5^FC[[*5Y_YF)X]4S^V<FS3\;8OGHI%[),
M7AI<5--GZ^O(OSG^L=;+4PO'LX\7M0XS;.4>3Q5<5\T#^0W=T7"1'(87;M@-
M75MUXRVD\&V$?QO)FY SO:7CT"U2)8]:$W7IQ<59K+I^!5ZI16WGI(+U[WZI
MA^$]N5I?^..H'U["YLG-BO*?)^F7*1N_N2+CIU<#]N#=;X ZN@G$UQ\= <-?
M]',?HY?P?1XD]!:N^>?>P'_8LM+TXNV'B=(TH'_ ]Q^__2#^^/)S]\_?W^$7
M?WGVQ]G__/7'V>L/)[^_^PS?^>GX2_APW#7XS_\]Q?[L/WW[N[DX^>O/OUZ<
MP>MO>W\=__H_O3_?OJ(OOH3N'V<ONG_^^DK\^?897/_1EQ?TU>7_?GF5?Q]W
M:+3*84+!GF.YM0+7R'@54!"1&FY)-#&-M=]N_R*&HZRI8L6I9]R"UA0X)P$.
M3FFH4,+9Y)E6!ZT(NNAY)N_J O2FG^T0\#Q(K7G!U>AY<W$&F_TROS8GIM9,
M3JVIH*9JUV2_+7.@P0<GUS_^X5K0=]_#XCU;8W%@4@B7&(</&LHP& %$ANS"
MR]9OTPCY*]#]^6((3PZ'W];?NOT @GI,[ZM(;.J6;[FA"5/##K,MUQV<+S!V
M:Z+2M3YU1Z?Y#9.[;YT-0NRUG!T"9<.>"/%C[ W.\XZ;=CJJ!^S9X3 "PW\Z
M[?K3UOO8CYGY6]7@TO9&E^T67#+87X-^S)^JC[/6.7P$U*.L*$?8/;4*G8^A
MR?G3RA< W]OJ15BUJ\.D[I\$BUA=^!'0UJ/6[_"5Y^-?J\-(<7;IP_@^L]SC
MZ47719=Y"6 'Q'[]]8"GFTLQOI=ESJ3U4OP"K=<XOWS@=$PZV!@<J.4(8RN!
MCGU"SAN'5,0B4&-Y3<>+]+HCQ/,2 .6[Y[U8'P4+PM\;+GI[>LV,O--N!'3[
MWD6(4X5SJE-^.AWT>I=H\*E_7:=LM8YZO=I_-#TNN]DLFA*='9^=P_J;1I7M
M#\=^BF'KU (MN1C[K=CKGL&UC.JD\;EKO&G77S]UMT@7M19QDJ[I<)</G3C>
M7[YX^L>7XR_^RW%]+T<=QZ7P3$6D0\I#X*Q'5F*/>,S59MH))VZH:#O"(;=J
MDLVC@6M!C\9<U\E%=0]&FO'$>6[J4(U9(O-*%>I>C[4N]>[1FT>M7X^.7HXI
M:\)BHPD!U@P$<@+3NI6_ ECJBJ#N9KA,< NDML!C^0N<[=G:6[!V4ML-8*R9
M>^'L'E3C'C:OH^]E%3>?/;4]'OZZ&(<@G@*E5-WS_.2#8^%:?:.=9&PD"E-$
MDR! N%J 72T9HE0YR862C/GKEJ543GF&@V;$<1RLTY'Z2 2G/!.YO4[5UP7P
M(Z;QU^WCNZ]J\2X<]B32 &>+2)Q3T&/A+_BTQMJF9/B&G?ZW0.1)K$8Y):^Z
MOGYS'')F,X?53O],?A^[@XMA[W+:!/>*(VMFJZVS^O/P 5B,',@;4V/M[+RH
M:M8[KT&3O^SJO'K4RM&&25@%+F@JDL8%1>;<,&]&P+JV"L-6KIKMCV!1CL+@
M',CV:D-=VT9;E_?M^_KN?5J?17$< W9@7W^J3?AT4=7F?;<_#MB.3Y7K]]QJ
MC''];AA/TK/AJ O7FI.H'R(?LT[@&HB,&EBF$!'W1B-+A$.@!N-@HDS&N!U5
MA4' F8:N1+Q7-O18\1S#%F[R/E;TE(*[H\OK"NI5P"D3\\5XW>)TW6IU$LZ#
MB[/S"9N?VE$+N  H8*S.GHVUV7$\:JQ=3L)9=UQ4;8%?]PC4@>5LQ/O1!;P=
M+NNB!^\]LY>MT$TY^I2JP1E\;@ 7>G65=VNPWR/NM?OW\E$Q%N/K[O##$S E
MNJ/\Z&'R$>]06*B0R\L$:(.(BRB1R9/:;6($&Z\#2WY'^6A!VK7M-XTTM++$
M]X:>KL*-P /97S^&>DT:YP!M4 8LF+59B?BK9I#!@JO.WU@E7X.B5<$:U932
M'<(758#Z"JZO?D,>P)(9[*/M7='*7$%)'2L8_SWV.\3//J]Z_;GSL=.UOB3@
MK7?];F:K.E(Z;+T??(Q5OU9H0W2C%F@]%U4]S:4]]P.M]U76BF>ABFOOK:_'
MYRR_6J,>NW=#K',]ZFNKU6OX,NMZW>%IKHRYZ(:8ES:3ZCB;)*\32#=6,[V\
M_EX@O^G/U$M\!AI\K<4/;8JCRTG8 Q8'UO#R4>MMG:PS]_VVBA,5/(= 8!&R
M4A\_38+W9_!TZL(?6>6W'X"IPT>0DGU?'Q$C4.!#?;1<=F,O3!=^/!VY5=V/
MEIN]F8^N!)"W[!FL4*M_<>;@$(+[AQ-XU >)3!TZXR$@"]L9EC9OY\F"96?/
M).RU]OR -Y,Q1<.3M, \)RFSS<^7^=]?K!\-JN(:KEW#&!YWP) G6G&%2.0&
M]&%BD-/&Y3(4PZRG&AMRW;)/. 7%0\(BUZD$;W70"IY*Q%AA';GIGY@$/K,:
ML[!9)ONI/0FG=H= $Z X93 .6P3_+0=1SP;5U5X:#4:UAE1_'WP*W@7_EP8]
M,,J&C^]T>UQ+IYFDFLGQ$7.K<7CGK1[^J\[LO/;-=7*WO1@-IIF.XZSF^ADW
MJ$*L,J![]GP8'T\?W,@?GS\',UI#=WC>LY>/N_T:M_7O3I+$C'E$I<%8UF;N
MI")S<DF3-+)'8Q/X6K[[^$5!'S'.)>5??\LW/__M%^DC197@Y#L_CQ]]XY/X
MD6"2*?6='R\7?H\RWND!D7,2M]BWX.K*B%BF+N''KGZ28+KZZF.SF4%^3Z./
M]>G-2/L>)3=3B@$2C7?,;MO@6^_8GTW8DVMN1_?-;3@Y4.KDT'/0P[,+HC7=
M*3NP1[-"M^F6*2M8L[('5KL'5-D##WX/R/UI+S+SFZVW2O'EV(9J'36CC/-'
M-N%8)=WN<GZUYG/L!;E6]FFY2\KA9)0.W 9F@L".VVA"R%7K\HYF&_1.!_G+
M*W<*N2KG1'1'_1:3>L[\WAY\QZ?CWU]_.'X+G_G]&3MY^Z)[_-<Q^?-7^/O+
M\9<79\_PB\OK]9S9Q_&.G+P]^OSGKZ\^OWC[BOSQUHMC^OSR^,M_/OSY]A4[
M_G),_X#__N^7YY-:SF>CXZ..BSRI@#4BU$C$ Y/(8JZ1\MY:Q:12.AT<\GOU
M(UYYM?@/XZE!=/2WIA7V%QI</PTR3$WD$I 2)<^)$U%1)@7S6CL)OWE'YXY"
M@^NEP<LK&K281!<-T*#70(,I.F1Y\(BE:"1/(6CJ@ ;OU?RMT&"AP4*#"TU
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MM[>FRS=.Q.+5%U&6P%-#2,C7HU2&<#RV6.FPB12L V)@([$ 7F16$^"IDP\
MS@&4%WBX8&'ANMC7"7_OZTF#$;Z=]*_Q;-IR+00]-5+#^:4+1+1N!PK$]J,;
M-LNU"A'Q+H @ ^,;7XQZ%P.6H;6('#/@7#08@,(ULFP@@"XPQS'ZIPZ#9/BA
MBB.-< KL,Q6*1.X(4^,^ ;#C-&R\-4S#ZH^Z'Z3ZNFT?U+6BV$>G&'P+$;@[
M-%G^+-A9Q-E?'_R\%&G/P!G!:/L%&-W&C:Y$J-]QPO=@OA],0^5O@%*7^^_W
MC[%4K>/4926W-@._U&;"4Y$)T#O"M5;*ZV<O1N.U*'E/:%.%SVA_6VGL27)'
M@MHV:7.@-R"+(_RL+6<5]2VG.P-<Z)WX)^Z=HH9T?Y6[@\'7\%D6/3&P!<!T
M_F:(G25'%B-;H1?;UL:!C2/'3 OF,'.YT++*.!:<%-SGF9>&&%VPLJS6:D<^
M=AK5RD2 [DX@'IG;LO02KGV)X(DL#"5:DIU^E>-86#?H<7UVKNH)_BANSEAW
M#GI>AY]BR>&@Z&UI<XL5V<'C'PSKC[%V<"B9'GH5[BPU7@SE>Q=N2HQG8>5>
M-XJPL=,SP@UX._A2&;Y@9WY?GHTGT]15%A\U!+_$G8Z'%L<\@;&E^%6S *9N
MP"%H%(E!8 GXT^!"H6W<\#;>M9>V$!A>:G>PCS6,W2CX'#@]6.N^GJ2@4G)
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M2\0F1@D621'!H<"H2<B^Z\A".C8QZ>8K%)J*\[4;(3<$C<+KQW,;ZI,+21&
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MBXR1SV3R.2FDI*H$1Z_@)3."L1PHO4"$J9C=8LH#D10\0%+EQGFO:*;*LLB
MD8+,: \+8XV1A M+<).$WB>3_[(-$)93VP]]$I C/.B\[7N0^AY@^B%EA6<>
M7'Q<<XZ9AT@3,R5@7CTK-55N4Q^#;^Z$'2W5I)N&,@F]/D)V[6C#<HVF@&G_
MZI7CW^D=N%L4$OEK.!DRGC7P$1Z'3_7 4]EM%6H^+KH,M46:\7')/7Q^-]]V
MI3U$.IY=Q@81\267KQ@Z/WVN9M/QC^F#4+(E?J+QF-8$5V2HSAOWO/W'C[TS
MW?C[^'<]PBHWSW&Z8?+.AVK^O!Z%B0_/30>D)7CS@O&B#,>"IQ/X7]L.*1VA
MWHU'AO\VM>M?YG272U*4Y=677/M[LDNO^Y(S(?-KK[CFRVL?3(%YB[SDXLL,
M7!)2,OD(!_YP9OQO01BC0(*DHV+]?\_R9RO'_2F>];\E7*VJR4<WF6*IQ/19
M5,X?S[$^]>@D:B*%N[<?1$VD47?;\3^\D?5Q?-.ALG2$C&^LVK",Z+<<_;,%
M[JW."BVZ:6D'BRURV/FG;O )$_&C/S=SJ9S%_<^=6)FZZ@9C]YF3^ Y+/L5.
MSOTNJI&073G#"[EK41Y8F+M!1+_BI3>H\<-2W8<UFEMHS#UK26(8H8O5^700
M"OT,4) ?@_Z@ZW +-;G7-?ZS$[9=_7M<_6J[^D]X]<NEU;_!['S.]/Z7,<YY
M_Q#(VCW-VK(+?6NB\55FYLL]_PMJ[79FMC-S]<B^ "8]6'?RGA!J@/_3%A/]
M?(#Z>C3^H:SE-U^Y_[YRG=B7E?BP+#=,TP.2\+MLZE,OBT)Q[SCG.55"4E)0
MJDLJ2U^:&ZO1Y%]I RY_I/LP[W[_9_/'T?F'@R,S/SPZR0^.?BO^@&?\<?1J
M?OC[_L7^^S_>'Q[9TWWVRX=W,/X_?DJ_^?<_3_69'<)[T8/+U\7A'O;]&WZ
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MSA8, [X,DP?C@&]P\J]ZS,[@ GM$#><#6$Q<,7AN]!=P=;N) 9G!.\3U0<&
M60/YPAGXSZR>Q*ESS12\"GA] V9(U:-VD;O7C:N&P_'@8H3!CC58*A7%/,[[
MVH+OHBY'&1K.=S9JPGS3+*N( +A4UIV[T,II,#L?QWF%H>);!_W!:<1QPVRA
M6.-T^?"NO:Y7?94!+\F.)W$FXM+@8^%N[J,:SO!.X;73= 1)L0XE&O1]4/N!
MLN_!I8K+'/IF.5PP-9ECP]N^',&"GXWA@OZ::&?&B"KJHZJ'H?L5S!3,^ C'
M;4[5Z"3\HYZ8V1E"B4&U#M,S'MDZ 0J,[F-X?% 8U*C8MRM*?3?RA 0'8U2F
M6.:\/W9XK]NO!,A()P@+6(*?CP%5+J,$67C*2K^\!T _%NYQX]3$G +SV(/I
M&X[/<1I>Q9>*M.-ILHU/QU(86&1N,T^]S3@M:2:5X1D5A<U)P7@E]2-E&^VJ
M!\'NK?L@+?QC8QA+[V-[[Y.T$]6FJ=%T P@&<K#3:?_. .$^7+[34H^Q"9VY
MO3+U$. %1A,-?P+_QM1P-=(&M#K>@_T=!]"[&$\^(%*=SR;-#"D%Z'^D!,-$
M2=#.JI.)2P9Q@<63JUX!D!,--)H,-$[U" -6,+AZ=/5O.E#"0?51/KX&W&,V
M00.'' C'U]T('G8R46=->@R^"S8?#'6& @3C[W>2+6O2"ZS<%.WJ]:^4C/V2
MS6E7"GX9UBO</'"#>7B+]O9P\2E@+%CX,_7!M52I":]RTP.!4X!AF[2LK?M4
M.WRW"9I3>$*B#VB>L2<DC$:=(6,,XPGLHT;:TC@4B%%+^4)P-DB-5D.T4(/F
MU+EI&,K%TNN=K7&>/E^[P53@WV@#ZM$LF,[;MYH\'S?!4CX'9A3D,'5ZI 14
M**D39[L5NNJ];YYMOHG2\,*SJ?LQA;O)U;]9;S3S[)X!(_:H6\"$W(P2)5F9
MV]Y_3R>+N/Z)R_3$J0^9\C#:YVIXH>8-1A-.)TLO=M.D7;TLG67O+V4TL\SE
M904&G2KBN7%.6'!MN6.2$U-87L50.OS&V9?34.VE,);(PEO!N"Z%<*9095XX
MP32O\-S_%V80OYZ"^/Y=-<[^-#Y#(8^=>$.#5& 5KT>XZ"!N;T KFB?**-[1
MPR-S<?#^ S^X?)T?[KT\5L@>%/- *3@V8G9YIJJ<9%03*V5528;D8GFI.2^X
M<EX65G-NA912425*6/A<$^T>:^@C"% 6)&C0%Z%'QD%^3S8*<!_?1X?W,;WW
MZ6Q  .#H'(#% G<B]!9NIF/S86?PZM<W;R(/"1\,8J?A9KWC]A*\IJ:^O%CL
M!#[4>?IEY97#1N'@K[_\^ML/X;534">:T-X%;\(%P4<?1CX7K/7:%,98BU?U
M9(">JT/2MGI-])^3]]JU=3;#<2 Y9VKRP2'Q0H[2!77.SL:C=DVBNVV#5^P'
MP)A&TT!B.L_O9B&(7Z4[]4<[PJC4=*)PSC*</[RT3H$>O#B$)\ ,=P1B$0N*
MP1)UH2866-I4?8@$#@2MG;"N33;,L7?U= 93LSN N>TWU5:#$$6/ FI<X*Q=
M &0T"QU(X1;A'<-3EV9GZ<V4.:V!B 46%BZ<G(]#7**_S"=CC.LE?SX"WL"=
MG0_',0QF9R'<@[?[B&X\$NSPQD")@>O"(WI1CO@-<KCHYX,A#SN[;1A)*XV<
M?MY-UO( 4X3L^E&JT7SA66!TPJV&@4##%D&%-NS5AB!L.W,POSK @0M3%L@Z
MC!>O4+@*9G8VBUQM8##PE\W.VWNEZ-FX'WBY'48PMOL(4 *4:1;I\N#O0WA\
M]JLY'0]=D^V#&*($!UC,4$>#RHZM&R[%ZU;5RB?I!-<,E@Q]HQB:0[Q=A]NH
MT^AM()C$NX,<S<[2U\D+"U(08.7C&!<*!6LGQ'EW!C"+H' CFR)507/KYD/F
MP?E#G70(2@.4,H2.**S#\?@#OL4I^*KC21=JK4$7ZOY#:K?P1<.PEZ)Q0=;6
M!Q;?I?L"KP[R,XJ @9C8J6YO  N@"+^=@.MK'#C-G]S$U.@<8? XO'=P9D>]
M@/AJA"YJ7!QQ!*F5,;5S-IC7;FA74#IJRY5I)A&75O/Q5"D4)5)3Q3DKN:ZX
M]XQ;QZR@LJ3'KS<E*[-5COL*$'<Z_]6!>0^3__/'@WH?E!8F!17O]>A\-NVR
M1C+VY/CM:[:_]^'3L>72"6E]9G3.,@[L-(,/JHQ60%N%X86F^MF+]1)D?QF<
M ,:-0N V*H+[9-QYW*-AA%0[K0V(&QW@3\-B#16:?T!)U9PN)*?SR/OVV@_^
M^[KTI#=N$DCH:M4\10P,OW0TA[&#BU1Z*7/++5>V4%ZB<T3:9$ZRELRY)D4_
MA3']BD/::\&A??1>>I].BLC3$R*X[L/%_OO]2[C_!8S_V.6*4YA6W.KU&?<.
MY(E9GFE'B#&^8D5)G[T >W955;MSE^AXB.F$"#WNHL4(#ACQ#J,WBDUK:E43
MPS@A #6:#N?M;ES$K;!EH.;+<ACV(T*$"I\3XV&V1A:J9PD-1QN?YF<(M6F3
MXNAJH[& Z[#]\]ONKX"EDX!)<R"&+5+%/4B *:!N@40%8&YJ,,NJ"X2MV80
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MBF6\(BK3!EQ@42CNK%#:%>39"[XK;Y]7_;=00.[1E$9]'>H?CUR4YE R$LO
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M:HN?VN^S/O4WK5B\6)A4/7ZI@O&M'GP?Q8OGFTH7MZTV6F/T_.&MW0H/N*7
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M@2?!@9GKE&J!1&I#YT@TB'O& 0<*A:BCUNA@-4_M31AK4:!%@:=PFUJ > J
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M'YD.AO"/],O\KZU9EF":UMFN_:': E[T[EVW#3C;W=S_GJH'P6_WS#.*I'4
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M7,0>&;PV!#M4@)>8,C0HTE(%9'54GD>O ],IPE7P^\">1S&H'CU[K4K-3 ^
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MIO>O#?8I;V+ND3B%U^0BS.XQ&([*/?JA,2X66$EFA& &<P$8*\#(A,W<>"K
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M"T:  Z&R$BSD NPO N:7=P*,@()=P09Y)4_,6K9 3\>)%*TDVJBYP5(KG(7
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MIH@F!5=%"-(RZ;U4^:3S N0U\DVF_<[3S?]."SK%+=SBU@UP:ZY#"PN,*ND
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MW+CB>TI9BIG'>9 9YR&XE'P45 :>C#.*/7!#D2OPZ0H/U28PW Q&FBAQ)3L
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M+NI7B^]2E'3AX,MP:R%G.W\5KDG6\:#O%-EJXRP?MCK;_5*:?AOB-SMO_W6
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MNG?YQS\^?(5UGNT>O/WT\8_77W=W7N>"V:I8%O[=/L12QR D1XD8@;CP&IG
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M0)@UBG#N#.:*8&<T$]QPI7$0FN+#G<Q.F&""9GPU'\S;B6Z\TQWYWF $K'(
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MH$0'?4/'\9Q7J?:++7CD;J!4WJES>*$E^U**F7,93]^<DLES[O3E^=[.[J$
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M\XE#;@Q*_'YZ784.7@Y&K>4W)=:][4.N./%:":1$+O8VN:\,EAPIZKVGP?O
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M>MVT1 MX<FI.X;G)IF'1_Z>L+3@%$]&?-WR]C=ER\+RPPJ/CN?3O60UG+>Y
M8)5#>4#@=?M?!H $H[I-Y;0A3W-VP^4>XC40%!V*RJ$1Y]>,6JA!9_51T=6-
MUOK@'GYRU.K=BMK&1<L:%[$GT+CHZ30B@K5_FO0OF61-$ZQ[J<CS8<=Y/41]
M:-N5]4Z*0?+,;AR#XXF+G$GM$$]:(ATXF']YI!<)'D<;<H/63$R,+M$UOA4V
M_>Z9==4XI&J 1AF5 ;DY;?<,%)Z=@K/^2-/Y Y_CPI2.14_-E1.BIMK, PXH
M:WV*C\0)>V\.@P/4-Y:@)"U%G%&,'!6YIL!BL!D52<58@^4^Q5DY["J#RZ8A
M]$N#RZIA3ZO;< ]1OMI.?%J%L'+/(AVTLXXCHQ- +)'962W@3V(D5R0*9T*.
M6>/K&F5]<_K3=-S=0AKW$B_M^ %GWE7=[1Y]\%V]+VLR_:Y<SIJ,P*L6L\H<
MO)EXO+JP\M9S\!8+LIN4OLY6ZCJ-5Z@U^-OT;VK5^"<C8^CNF\,H6##"6<2H
M 1DC#$6:2(E82#XH[20<VLW4^!O.67A,];8=L? ]U *JKI=1R<@EHC8W?A')
M(R-#1&#O"6$YX2R7SS(BMM@=3%NX[?B A^S%THX/N#4YG0$Y*>*3T8@YJQ#G
M8$-91CC2F'MC-1";X1LOS+4S!!<G"5R:I+'"F([MR5&>Y5EU5V"9.G^/;CC)
M>>!R<YJ_S-=@5L?4XW^G SL.;C=+H:&I/^Y A7(AMY^J\,04Q-^KN$V5L5;0
M\/S0UKG';Q9 -#3'AK)]28N$W9_+^=V<90\W$H6KXR_3A<OB@&EB<)4YV<@-
MOJK!T?RB+ID 4Q]=HV'Y21UP*SMWU2G#Y6*F><,+8VGS-Z;Q[\W:?(#W\_B*
M)=,EFX]R^\3B[\W]N*O$XG(VZ3.60:^_[A]\/MO]M'N^?_!![.]\.+3:8BD,
M1S'YB#BSH--HAQ$( $&)-,RHM/&"F&MR.RH&Z*^FIJP+3;3)YDM&,VP?LDBC
M$H(B&:C,7>HC,IY)) 21T2AI>9YPK*[)-:^ET>K9Y=\8([EB;M *4JU\$C"E
M@3K\'70OGZ?"=Q[ ?=(#*ZNHS,V*Q0%<_[<>2(!G1W"?.=R;[NZ\H7E-NQ?^
MD&$<O,LA-9HTXM@P9(GV2%OK#=CC"8S@C4X$%CW-8?KA)*Y)</E@KN_8N.SG
M.3G)*9L711%CB5.%BN<&DU(/KH:$S,GC63Y:PRLX'465/]HL'RPJ6$&KA]='
M/R]2^=7Y#+ P4/K1>'!:I!Y4?U:9$56A;_44Y26J3_1B&O\"NLR@_DKAB"Q?
M<3FQ;YBWO&=/1_&7^I=?&[?/W_^U656<]S-T1Z<]>_Y+MU_L;''?*C?!F"V%
ME<2TR% 8#^&_4"^IRE[8*K,7_C$.BV\*M644EHI?_9%KOW_]FW(K)_Q2?<OO
MXRUR]9MTBQHJI;GEU^]TX?\H]KW<>SC43&3_WP;(WM78[3(5%"Y<D+75:R7M
M_7J:)YGTCTI"(T <]0LEH9&2-.LU+UE-_?E,VO3TZ_3[%6WGEU9?<,4UW[/D
M)D M2\]J)&-=!T7SH'7#)]EXL5"P,<6*JW?R&9QK<?,?Z%C5W+%^@V]OLZ/_
M)SNA4[K30[_A%O+[V<*_RJR67ISKWSZ5N(U9#9=9YL&VL1*L^0:P99U"1^[D
M!UW<X$??SO^Z$ECH71/>=<S[[2U;(Q)<P6)66@=' L;44DZ(-I@Z2PBWQ&NN
MK5X^&V8E0_F;$R38$S54/OS]S]''@]//'_Y^V]W?\?3CSFLP3L#J_?OUV8>3
MMY]AS7AOYQ7=HV"DG'S\_*'^SK__>>Q.0F__Y.WQ1UCCWL7'S[N?]KI[\%P?
M/OW6_?C'&[C6&[Q[\(%]/-@[^7CR]M._+UZ-=]_AKW\>P+^?BO(PII,7*EI$
M:1*(1RN0=MXAXFETS#H;J-MX0=4FHXMC@ZLX]"V$]GT@=HN +0(^%@)J0937
M#E/.(A<1&VF4#MA;*K5A#A<(J%H$7 L$/*\1<%?L;Q\Z:3&-)"%-<41<!X.,
M(011SXUR@:M 1$X3O6[4ZWTKN/=OXSPNIS4J!V>M-7XJ)^5EU]6D^7[NOS%7
MCOSS#230TS;4[FG;?WH0'>^&):,[U;FW>+82GKV>:73;AY:SE)+BB%@=$%><
M(L>$1R$%@4WD7N.X\0(DT@*.W82'6M?+#\71#ZZSM,Q^!\Q^/F5VX213,4HD
MH_&Y0RP#9C<1*4%HT%9B*G-]"][D:G&"UL_K[).CZ^G7/"BGD)>IW\VF#F5+
MK&IBWOHYY%J+]#86Z=,W2BVCD=K(*7:".ZR=E\0K%2FWV$G)[\ M5[BC_RH)
M_V7)&"VDKP3I;YKZ&X"XLY+1/+83@_Z&\PQ8)Q%.-L5(C=!YSCF5FYPMJG"M
M-ZZ%OQ;^9O GL0\T):IL!/T63%0E?92$8^VI I/U#O3;%O[N /YF&FT@)$@O
M&)*@PN;>!1Y93ARBA#FI0V#488 _RC<%76Q7M[HKKLZ6REU'ULNXO;>5-?B=
M ;^'P22G4UT)DVNS[O5=V9WMZ)H98>OIX%B>&#'-/5R'Q(A6U_C&QJP1.:V@
M3D1!E9(D6>4(#SQJ3S!()^.4-Q(+W"8YK(M.\;Z9Y$!WSPY#;@1F-4?4Y_+8
MX 72<'[(<<><M<DS'C9>*(%O&N)[3G95"V<_))RE1!S'D9'H# <&T=X HCEI
MN!%,F70SZ^@B#@?!CHY;)+LO)*NL([A7'G),.#5<&((2QP&0C"3D'!'(4<6H
M<ISI&#=>%".EZ*]MLD*;K/ \0YL/KJNUH<WOA;H/<TK;WM&A,280YQ3RDH#2
MIEVNNK,1I>"=D!XK@GG196V3L,74U#:?X8=@^C55:%IVOP-VGVHV'W(:)G<6
M;+(0D76!(&X\F&?4&,2ID,Y;;C"UCZW9_+ Y#;U!WHD\O;#-:O@A;-,?.*SW
M %D-?P(['  W-,-[+;ZOA.]^JLYE?,]]R6V2H()'I)RRB$OFD?$F#XHD)DFM
M-?%ZXX7$9E-+WOK@6A!L0?#><QNN4G9;_+L+_&OHMV#. LPI2V)"8)@$Q).C
M"(S;@)Q5TGHCO=>MY^Z>&>SEPO3OJMG-;-S:7#CY#I7>!\PP>/1MOB_X_RYO
MQ\TV<8V(=9W=G<T))!5/E?&=_71P'"\-L&PEQTJ2XZCA"'W_=7?[4)K@G>$$
M"9ZCUT:!Y-#:(8^Q!UW:8!SQQ@M"U:8QBXW ;Z\Y/YPWM,75%E?7$5<?TJ7<
M0NJ]0FI3&<^)QI9Y2RTBVB;$793(*N^1\(((387&Q#^V,O[CY6[^/M>FN3DO
M913[W<&P\C@W<C@[/_T9O\1>ARZ$\]KTI\?VKJPA@:V7%_G2V/9,_?_*Q)\C
MAKU!G@(P:G%\)1S_/*<:[V\?)D!Q*[5"G!+X89E%1B2)<& 4QZ2S<KSQ0A&V
M*=J"N1;9G@6R/4#96XML]X!LTZY4;_C^FT/^_[/WYDV-'<GZ\%=1$'?>F!M!
M,;4O[0DB:-/N'Q,C<-MTM^$?HE80+22N)$S#IW^SC@026S<"21Q!V6$,6LZI
M4Y7YU)-9N21E9, *&<,,XK"82%N5D'0I! E;4PQR99USN<KD+*I2O<'$K3*R
MN8ZL$KA_5673K]NUWVAC<*,8_*W2[[/N;#]][?R-JM+]_9T;JJXXO3CL<-/I
M-L!&&57&#S'9L_:@ <;,WZUNVU[%TN0^2;E[8Z=JFS/L<)2;2Z06O.*SI3-N
MMW2[W=&_;O6W'\Y;!:H'^( +M7)/<?V)^21\\1-Z.W+IG@E6:XUYM[4X.ST=
M]B.R[?>VG4.P_SR*<3"Q3=6ES<7VKK_:I2Z:E__YUOP(.\S'/XZV-_?P]O$6
MV3O>N]S?;;>:7S^+;?KE:/OC'MGY\W:;BZW+YLFG<]AA\/['#_"]3W"?+ZWM
MX^TV[%K?80QL_^L'O'_\6?QUN46VCP\/H@K1>>\0)BQG7$N*7'0",<V9BD$8
M$MV07X#TQ;"1V8&-S'(K)5,J<<V2Q<ISH%=>!9(,%;=;88RFOE'-?6-CV! *
M-&M@6^W^'4SX8;>(47L&FB5Z0L+%6, ?: EV2RU&9+$*RGL)S:CN]2[W(&SY
MQ^C*OV]!P%!8?[X0-Q>.XF1)Q%%(KKE5&HPCSH74W"@38@!+Z<^C;F\P# 3<
M HHW:J!X#P+]9'XG%N7.1TZ[_:H9X[NJE7+K[ZNF&@3#HXX>F],UE;\_\<[*
M_1>QKM]MGPWB+Z,EQ0]_YV[GA%DO_4:O9=L3"V[NWUH4OP7P$S^/>F-#YS B
MUXOV&[()1OO.ML_M13]/Z5'OQH/];-(>UHSKYD)WA>NGPG)+N(010AK*L:"$
M:R4,?#KE>@XD!3! _,J\FQAE2V3<8WCC;T"7S#U^Z_;^!$.D5DV-%H_VXZ9&
M,&ZRL_OM0%<%(85#U%;(KP725:MAR04Q2E-*XGU-C1[6]!<F;#]I=I1[%EUU
M&VU=8UO#VT$\[/9:N8W1X &Z-VIP1-2MUD;OIF]M5,M>1IP(BL73>AEQ>%=K
MRL1<>AF1-:DDX,$\>AGA-<$$-3]HPO2,7D9EX#4?>.D>-;?N47HQF2N_=ON#
M>H>U+$U4YD))\L,[^WV"<V.C'U+:C[UNOU^ULH9Q7L8PQ2Y<NV<YM*U._Q8G
M+[)<9'D99;D-CQ*+,+]=8?[0'[1.<IOD99;B<2_Y>R3Y=85YU;FKYSSSXZ;%
MAH6&?Y3)*9/SVB:GI*I-#:(3)S&MR9.8);-WRVC*:,IHGA5"\VKHYIR0LI'_
M>6\[WQHA5L?"LTS;+1&U):*VE;#AF'@;B)&<"NNDP=)H+H3WVK,P@UR!V\?5
MMPZSKXJ-99_W>]MOU2>\]JE'V:/PVG;SZX?+_>-/\-_>Q<[7#[BYN4%WOGYI
M[6SNG>]__7RQ\_%+:__DCV_[O]X.K_W\?6]W^V1[$_X[WA)[NY_.X7G$_M<M
MOGW\OKV_"^/_^I^3?1C/7Y?-R28[@4<EO&:(>>\1SX%/5C&":$B4TV"]3W)E
MG1&RBF7I>5T@KD#<CR!N*ASS_NSDK)U=A)7C^_.UW_NC;77>1X#+N&N_%W";
M%MS&+72LII'A0)%0+N1B 0ZY@ E(EJ4B:.DU]KF#6,&U@FO+BFO35()^:6#[
M+_Q5@.VIP+8]9FW&AQA8TKG;K4)<6(PTI10EK:.5-))H<K?;NVW!GE0)NF!:
MP;37Q]6>;(Z.D>XF[A5 FQ;0QDS-:>4IE09Q9@'05!!($V*1\1%'')1B_MH,
M?53N>CEE>9KO\-=N[[3;@[V[X;J=\)@SEH4765J&N9PF15U'[[CBDMO$58I.
M&Y8$8QQ'H;%TQ:%6=R2[T;7:D,23D@P1+<#F))(BPZA"GG'%HF-!XKBR+M@J
MI;,LPO'ZXL4*!#P" HK#J0;*/Z8QS)%<,$TCH2EP&6T,*'\R2#ALHV(\$I_;
M]!2]?\5Z/XU#YJ45OSADGJ/X$PX9+(50%A-$F+&(<TY \:-%,3D<I4G,,KJR
MSD5IS?4ZE;[>?+]X+&:E\>.MGG,CHL48,>X%XC)QY+!.* 7MHE(>" "I>#Y1
M=]VPI6CJ3%P4HX8%_6N!GI.[XHD>U3K/Y!2 I17SGMM X0>G'!L +@*(%:.6
M+C$Z(Y)2O!#/0Z?/DUZ(J!T&6R0AG5T17-" K,4!.25@Z1QCGGDP1-A=0E+/
MH^^BR"^JR+/R-!8/Q'P4?X*6"!Z2(0X!%\$(^*5#AGJ#4HQ16"=<=$!+R"HQ
ML_1"%-5_$ZK_4/.&XGYX":V?<#\(:4R4RB!GL_LAR(C Q&0H,>&$4H)JK*9J
MX5#TONA]<3:\L'Z/=W5L*36"!10-5H@G09#%V"!JM30Y2-])FW=U]KA8UA(<
M\53/P\E)[/F6;3=.[6GLE>B(N0-8B-P$IHWQC'"OK&;>2DT5(<09Y4NZ4>V!
M;&_2+\&$3UX&A906%'&M/3)2!I2(QM$9BE,0*^N4BE7%RC%IP8!G8D!Q3M1
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MTQ9T+.CX5M&QN)'F!)G-:\@,D4;,@D<^I82X]@;9X#S2 =2 !2H3K;*&:>F
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M@0B22UKAY2II^XILGX(P"T>8XFB9$^R,'2T,C*#DJ4=&,9ZS61UR%@PA)60
MTXCQF%1.[=>/XDL%=PKNU!-WYNGV+6Z9YZ'1V"U#+0O868XP=6"_2<:0=<D@
M+P2UA#AMJ2]UO LHS $4BO/F991_[+PQBOH8K$$TFH@XT!!D:,#(JB2Y(CA8
MSG/Q-7V/6[8$Q3S+6W-R$GL>J$_CU)[&7CD\F@-*,<)=B#)(K!*/4FC8SXRW
MG-B4'..\1,74'JWHI+\FVF $IA&I1 E0%2^1T5PB$CR.,BJ#4_;7J%7#'E6#
MO!Q0%XRI!\:4J)AZ8<[866-R.R..!<*.&<2]\\CE4VMMM3$.1-?FTF,E*J:
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M#DL4DHK :#5!-F1NFZBB$7.+F<[%$:6I>P^^ KD%<FL)N5-U GLRYA8_81V
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M#[G:Z)[UX#=,&\.'V^KD_)]\7IL?LW&><SE.8B?$T!AT&ZV.[T50R\;@*#9
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M%) @AAMF"%<JEYA=54RN,KS$WJ3B9GXJE7X:)I2<GF4!@S%Q9M)P;8)'D4=
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M*@#ZQ7HSA2/(D:B0\8I1%D!,O%A998*U,'Y>-;]?D#?XM6#7]=F)G8[$$)6
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M3X"46WNQLN<#6XU!$C+MJT9P8'@$0)<Z\,L@'O4!^WN[U1$(9#\,*[!5ZW,
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M'P7<%V^>KH%A]XGESQM;[\B7K7?BR^&_#S9.+NW!WO^(-T[?T0];[[Y]63^
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M_N)8'-K!;J<W=;W(QK-R;3N^2\)7_[<V:2_=N?:+V?&H__/DA\:'4_\R\?O
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MXSA)FV[BI+&[O=LO'9 $+382J9ND[&A__7, DA)ER[9L239IGYV=U))($#P
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M$M-S?=OT!1#_, HMXKH*'M<<ST!X1'A$>-S,,W0-/F[I(6(M!Q$"Y3Z ,EP
MI72=. !2;ZH=S.0>MTS?Y8'I<$E]+[)\IDH>LR%!9]"V*^EM,IZI@M:/X0YZ
MX(H[_?(5H'!0.(\K''1!H0L*67*/67('75 UW4!V?#=V/&\[H1SI131V801"
M+S!Y;!$S$)%G1D$L_"B0-++$B]=TZ*$3"@$2 ;)?3B@$R/L"Y-(-16#;(M2.
M3$HI,WDH "!Y2$TG" CQ79L G5;F Q_MK B0")#]<D,A0-X7()>.J-".(\<6
M%& Q!H DE)N>9W-3"L+".) .[&P*(+U^'N)#@$2 1$<40N7]H7+IBK)\YCL\
M$*85,4O5FPK,(%"9G7WF66$@J"OD+EQ1HVJ:4@OF[6/;GW?8E_T:ZE%H*#04
M6@>$AJZBN]&&WW7K,C($O( XDY7KO?CG/SQ&&313)&$7#XWO8+IT5)^MY/^(
MN:B:&7%838CCV220^>=8\[CB\ZPL2I$J::X&%^%1\XT8'6F[3V+7<GPJ')-Z
M 3 ZUXY-(8EK>B0.@&I3)P@),#HZ8*2?]D%$B@='BH=,9H5(L5^D6/H1:,Q5
M'8S ])@E31Y0U_1CE>#.]PGW9 BZ.:^0@O8K"0XBQ>-QB@?,AH5(L5^D:)WL
MH+X3"I^;TK9\X!1>8/J!"S/'MXGC2<J /VJDH!Q+>R)2;(04#UD%$)%BOTBQ
MM"?S2 2,@/;!I66;,*ZQ&00N,PD1L4]#2J*HTCZ(BZ4!'\#6$E4^DF[4"'QF
M"-<!^TKM(KL"=(AQ=\,XVK:PP);D>7$4FRRT06\BD6,*S[;,, 3UR8F#T-/A
M!7S@D5T&&#R]TD7/# \Z8$5!/-@9'BSM*%YH!U;(J!D&  K<IY$9>)ZC<H,X
M1#([]&2%!]S:I7;4)?\A@L43-*0@6.P,+%JF%"<,:&1[)F-V8*I*ZBH_AFV&
M5#B,!';([5B#!;%W:71%\M!S/.B N03Q8&=XL#28"!;RT!7$#(5-3!Y$H1D0
M9IG4\=TH)AYW>+1#@\F-P36/:F_=6\]:0 %M&U$V"\;R@4*G4*)=ZG=W>X82
M[:Q$GY %VMT/D5%\HP><%)^/SW\>S\=PY;L!V&E6BK&1RW.9SF31D8PV>*+N
M3H6^.C2=[E#62\8^)RKGOA0A)Y;EN;84/HUCVW:<@%8N :]Q$7I;N0B_5O/[
M?9Y-CJ /JG>_)^7H:%: '&7^[GLXGBE1'A:%A/]'I^([:O9WT^QYVTTH;-#M
M*;%A=L6@V=/ -85@L>G+2 C+MX* AT">_ %SW%X&32$P(C#N"QACBQ$6VUX@
MI<7]R!)^Z/N ?DX42<>5#3#R!ABW\94B,#X$,"[]I4Y,:.PXCFG)2)K<LJ7I
M^;YM,L&%YS*F;-H C.X OD1@1&!$8&P!([<<3SB!;7NVQVE$O="7U!61JX R
M=-P:&-T&&+?Q"R,P/@0P+GW#+E,>'QJ:7J#+SPO/]-S8,D,FO9 *&3,;@-&R
M!I:+P(C B,#8!D;JN''L699OVP%G$0O\(!9V0$(!# /TZPH8&P>YMY6#'('Q
M(8"QY22WB0?:0&"2T+5,#EJU"3JU90:6PWP9!%[@.2]>VV3 G8V \0GY=/9J
M$LVF,A<E= VD5)2%(=+(D-^G,BVNFDD?)PJH#[+LJ#WP<S.X1VIL#]/H73VR
M"%5W@RI[)7LULWQ*0LNDP,Y-3E7]*\I=$[ZEH6\[=B""%Z^I/R#V1O$\C^U+
MPI7=/X,6KNS=K>REV2H6Q&?,"4U+JL0J3N"9(F"623S.:,P)%S2&E<T'_D[S
MBN+*[OC*?DB+#*[LW:WLI=W%<1R/A20$?<+C)H\H:!8V(:851M+G4C!/$%C9
MSL#S,";_&:WLAS0IX,K>W<I>&@X<SZ:J9(PI_#A4>[8%?X7,M"W/X@&1D4.4
M#YX-*-VHF@Q&5MUML7VH2H65XGMC-^ABWL<^2/+&3-R/:$6H1OA4?*_QZHU,
M99R4B%IW0JT/%VT;@A79@#PV,YF,74 M2Y@B5-:$D$J/1J'-;1OX"( 6OR4K
M=^<\0+C<=[_<']*T@,M]5\N]E8>16X$4GF?R. "2$CBQ*8@?FI:@P@LC&D7*
ML, &C-^6A!^7^S-8[@]I;\#EOJOEOK0V>)0RYDK+E);-8;F'MBEBUS5E%#N^
ML */2_;BM35P^%5?)B[W9[?<']((@<M]5\N]98( E+8='W9W&OHJ(V)D^M22
M9AP*AP4!"V7@P')W!XY[&YO'L(7;%M:MY<G1+MJS* 48T0J5/L)P(A#=#8B^
MKYQ'@L%R*75,Z061R5WBFX$EB1ERVV921IYG!R]>VP/B[K(N!#HY.KZ8'])Z
M@(MYN\6\M!E8MN0P7IX9<3< 5N%2$Y9O;+I1&/$H)K'GR!>OG0&Q'R_E("[F
M)QV+@(MYN\7\6_M G) NB<R(^L+D4<#,0 4:A82&-(Y<2[#XQ6MOP)F#B[GG
MB_F!5?]%*5U<U@^TK)>:?^2PT+5!\R>$*\+-B>D!O3(Y8V'H^9%G<_O%:W=
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MC2-XI'$BPE%A_%-,IJ] TQTN"OFATP,5X;Z*#Q5A5(0[(T<5X=H/11AY(/+
MO?- I^WT:+- ABRP=RP0_1](^[HC/J1]2/LZ(T>UI2'M0]J'M$_3/M=<E_O!
ML9#T[9WT>;LX^G<(+ZYF#5R-IC_D@)T5'W) Y("=D2/L<)LGQ$4.B!SP:7-
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MMWV]5U$$66Q\6!7T4G%8J ;MQ"U*)9 B'*D[D[(PHB2789GE!7*(>WKS425
ME>"Q\[.H4\H4-8(=: 0.Z;)*L%XZE#R,>%9D@HH)*B:/SR(Q_<NFDD+];3,Y
MV2@GU-_ZH[]E,=PH47U#]0W5MYX*$=4W5-]0?4/UK7LD<GR61I19E'KU+XQ2
MLTXHR>B0(@7<;D6>S((BB1*1)U+G96\3O2[C&/;F"?0&U^.5]?B_N$7B%KGM
M%FDMMT@+M\CMCSNEA;*%*','C,A4PC_P,9=G2:$.K4?&=!:,D] 080C-E=![
M(T[RB?DN3XNRKF+R!_QR9GS\^ 4W5>P-;JH/O*FN672XM>+6>O>MU5IJGQ9J
MG]MOK:KC"[=#,#>^Y$D:)E,Q-MY]E^&L3,ZE\;GR+PR,+[.\F*G*7F5F?)V-
MH0/4$B;E/X@?M5."VE'U::"*C(DHFY9Z<U[>=2*K<F 688VR>R+R0*2R,#]_
M'\NY<1CJC9X1PC8_I]*M#0![TY?>("+@5MV%/?");M6LM55CTH_];=7ODU3
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M4"ZVJEKH?I"XQ*N+9P GTI=S&"P#*9W;T1+#5"W,DR8178HD/?5J1654I4]
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MFVSN)T*\X$5P1X0((3 *?QI8:CYWP%C5@QA1":U0+%T9#9:27)A7XB8%*7U
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M13%V'+L?'IG::(K3ZNON.W=F\1VF0+78^>!VJ.7\O&DUI0K-MS21]*CUCUI
M3_LYH/CW8V?X9GW2GIE>$+V4\9?U5C-Q-+3!^&3%TXGYV<R_QW[Q=?!A.Q:G
M(I$S4F\U4RX>BC$RQ!I:S.-FU.8R^D)M^&9"R5]BW@-YWIJ%!='+F<LS. JO
MTBA%L59#FD?)^=7=;E\H\DP"WNX?'K)=;%O+2.5HP3?"BB*5>A6733U9N!RY
M^VU%0UL1B=6<'N-K8@494.@X<2O44B_F$G99B6WS-AP^1F^G(#^"YL5B<#N1
MD*MPX'WRU&L;UJ_!_LO5^"\7\?==_<^1-V#%%XXQQ3/TZ:?_!U!+ P04
M"  T@UQ.8=>('I@U  #F00( %0   &QG;F0M,C Q.#$R,S%?8V%L+GAM;.U]
M6W-;29+>^_Z*=OO5.5WWR\3..M1J:49A=4N6-#OV$Z(N61(\(* %0'5K?[VS
M )#B!2!!H H\E!VSJR9!\E16YG?R5EF9__K?_SB;_/ %YXOQ;/J7'_F?V(\_
MX#3-\GCZ\2\__OW#2W __O=_^Y=_^=?_ O"_?G[W^H=?9NG\#*?+'Y[/,2PQ
M__#[>/GIAW]D7/SSAS*?G?WPC]G\G^,O >#?5G_T?/;YZWS\\=/R!\&XO?G3
M^9\=&HW61C Z<5#&<(A9(Z0D-(N1>VG4?_OX9R:Y<8)%R%D74*%8B,$[R#)F
MJ55 S^7JH9/Q])]_KO_$L, ?:'/3Q>K;O_SX:;G\_.>??OK]]]__]$><3_XT
MFW_\23 F?[KX[1\WO_['K=__7:Y^FWOO?UK]]/)7%^-MOTB/Y3_]KU]?OT^?
M\"S >+I8AFFJ"RS&?UZL/GP]2V&YXOF]=/VP\S?J=W#Q:U _ BY \C_]L<@_
M_MN__/##FAWSV03?8?FA_O?O[UY=6W(R_ABF^4]I=O93_?%/%_*E#U],E^/E
MUU?3,IN?K6@E^E?/6W[]C'_Y<3$^^SS!B\\^S;'\Y<?)QVDF.KCC8DW%?[WS
M>3]]HS&%23J?K#Y^3=]OGEI):D0N_K'$:<9\==&',.;YF]_>OWG]ZI=G'U[\
M\O.SU\]^>_[B_=]>O/CP_A"N['[8\2S9D]!+?M0%+Y:<S-*U7YI4E,[F%W\Y
M"1$GJT]'YPOX&,+GT>MQB./)>#G&Q;-I?K^<I7]^FDTR*907_W%.\ABA+]K0
MVPPF>P/*TNL;-7TEC*57VM%;+V^P:[.W%=1+6,05WC?K_539^!-.EHN+3U:,
M!<8WL/^O^Q*VYG23C8\P*5=8$*2Z(NU1%]IC8!Z*<9DK5%&9TGF/U[=S!3K/
MYNF'V9SV3=K]QQ]^QZJ+-XI^35"8IUN8NJYF-K_QT^+\;/UFP7B)9Q=_7[5^
M1TPL9VWXOI8K;>58P?^"<?F*-/I\I7B>SZ9D/9?C.,'G83[_2G;SV=GL?+I\
M4SY\PO5^G\_./L^F],NCY&WBQ56[Y30H#!%<1 ]*J2@],4(:W@,H1]"\#[#$
M]P"L4\FU&1!I^;/QLA);N4$$+XE(<M[JFY&$HAW'!)F)"*ID!4X&#L&G0"^%
M$D'&'D"[@Z9]@"2_!R"UDDLSH&S9GXW62:\59.$8[:\8\"ZLON+D7+N<(^N!
MC_OL\'98J.\!%D=*H1D:GBT6N%R,K'61.:5 ^BA!>2(@<.<)CD:HI ,Z##T0
ML%Z^S2:>G\_G5?W&%"@V,PI*2);4KR ^TK: %XHJD_<RL2[:[AH50_+ #I#Q
M3;@>SN&&GE9!6CZ_FE)P@Q_"'VN:?L/EJ"3KK;*1J*"@=Y4V"-K1MP8%6J.*
M+:F/([6+I"'Y20W$WXCWS;#P=C[[3/[8U[>3,%V2<JX:]'.UL94B+8/)A5NP
M.A(ZM0W@?8P0DT04MC"%7=[_NX@:DKO3  _-^-\,$:]JUN=C== OH?GBCS0Y
MKZG+O\YF^??Q9#)26>L0%(-2K (5D@)RU1EH88CF4$I,N0<R]B%N2)Y/ X0T
MET<SI%RN+J*7Q0B*RWBD?V1UWS+YX4X69QR27ZYM#S0\1.+ZZ4C\(+X>+=6:
M35W%6#A/XS!Y/4XX7>"[RK+%*!KFI2-H<1&0*.%DFZ(G@3A3K! IH;HAX=O)
MV;L6V$>"9O@2;,;#9N_HF^4GG&\4QVR:-FYGX(Q\"N'(G)0 M!NDO4D!&H.2
M-B&6/OFRK=3L(WL[?-FWXW@SX:_#X5]Q^6E&#N<77*RS)R,B/Q8E.'!7:'N)
M95@9CYQ#]JJ8))7L(?X=].P# /=T -""ZXVS$M_"3<]0B@(FY$3AIJ3H(@D+
M/ON$QCIC>9?P[HZ _H#\;%A\J@E ^D]E]9<P6:4$EQ?YY'\/DW,<&8Y.<A4A
M%\U "4'<CIQ!<IBYTQF9ZI*)VXNZX>4T#D'(K01M<\&T2]5^FLV7'W!^=O6%
ME-R2/78.R),BI]EX>K\3<U"$MAAHHZ;T2=9N(69X:8X6B#B:[8U-X7LD>[S*
M0[_\\MMXI'B.7C#RJGVDK3&>P!LFP5F-VFB;8G;][.!U8H:7UV@!@*/9W@P
M[S AJ20*HVL$?;$W;9D5KB!DP<@G%^2=!W+&()&I%N@M_:]+'F,K-<-+7+2
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M7J*)]<R4_$]7H@#C!=-:,V%3EX8,.^CI;XEHP<U:JW5'.6F/Y(% 2'E5;^[
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M%N13D,DJ*<")LHH"-;A:7A8,JV,RM,]]RKKV5#V'O$X+)([5V0B_D'@FL]6
MMXOC*Z]+888KL,6+6FR+$"PY5U&A"CJ)P&.7(7MW4C4D][<-4FZ_**V$TFZ>
M&H6L\S ABI[EL_%TO%C.5Y?8+XB2UB@4@F+7R#F]ISF#8UI2*)ND]-XQ'[H<
M;]U#UR#5:5.LM!1,PUO4"W*4ZZRXU5!EG'\9)UR\GTWRL[.:<_G/]3D 2I.X
M1@:LCMQ010?PSCH@;SDQSF-Q2?0 S7[D#:F&O@]V.HCI!! :V1R]1!&!.Q=
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MX9WPO.&B7\[EKZ2O%W]WDU5?1\HYG01%ON1)DD_)K:SC(0M$7XI)AMZ1<@.
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MR4-A-[L-'^=4W21@2%>F>@+I9$(Z,9P^$"@JK2]GY_,UL5Z+++0VD+E0M4*
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M#Q)U.4WB]+#R@Y,-\.H/E".%TP\U5P+0U:89-QG)&$AEB*C@JS%P 5+BSMM
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M6NCDW.TR1>IA)&Q^_9A!'T<M>'*>W[7AJ[S?:.[Z3PP+_+=_^;]02P,$%
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M.I94D;S2'H7,O 1I([/2)^>9U<91D<NX RN3MSH32AWZ,V7"DT?Y$YK!9^;
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MQC3Q*GJ2N=8R6/0^3;LRDJX0'2?-#J>T%=3;^:*AS4*F1Y8]&X,V$<.:X&A
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M1VQ"+3/I50 7K _L$+K]4IR6O6MV_M2#ZG75RI>T*E5DQFA#)8#T5CI#2P]
MS[+4@BO1DP%UF+(GAAL,#<J,9PLJ$F95B@I)0<$<0JL?2N96F9[X"B:^/]B[
M?N\\_Z":OE\:2SIGFB<14-GHO$GA:1#>*$DU%::4G$!/A\2M*(U! 'U[J<J4
M2R4E>CWHW^<<RDW^KSLX\=.5GMQ:Z8V#%@V%58PHIS(&I)(3ZVEQ._"[U,L4
M(V_EQ]_WE)UBD!4?/'W3>LEG@*0%R<KK$AA%4J[BB($01+2<9W#;0O_2<3SJ
M!X.[OF.WVKD54'0BM%5G#[^4):;)7XK["DCO"<8MU]]LAA-D_^O943':!3B]
MV[>SO?K'HTFIHD@7<7(R^@RC;_T(SW_TQSTOA*** XF0(EI),1T6Y0CS3'*F
M6!#0)BD</_]&Q(%_6HXVU@'HD!A?40:C>!& X'=A."[E"JV)LH5*FPY%V^'9
MU T\I9O;'-'XU33X:@6JAVKP%X-)QWJ_BZ;+V'*A<K($_EKUW2CJKM8[DO+>
M*)!,Y$:90)PKH0P%56:@&F*,P<U3)QVH?**JGWWT(36_B7 K7+/.AK]?OI\>
ML?3*PS2W0"#0:4-:21P%( '*C1]+%&*5I)1;*/9W@-2A9I:[]VPMUJXO'>9(
M<)EG/D[\'!$3& X%8"3;',NT]41"QLTK::"":J-];'>$O/+C]W\$N(.\FTZ%
M54E]__OR',71'\\19<? A\ (#Z79KTN(R$9%$LL41(Y4^G;N]\J/?^KJVT%8
M75_BS!&]_M:<P6#!)Z<-[AP>B !JB(Q)$J\QO/ ,-#51*ROH)MJ[]>E/77G;
MBZKKT2)S0--Y$W,X2E(:RL!2$TIJA-&(Q)>9N9D[)Z1PGK:;"'KWLY^ZWK85
M4X?5$ GZO7=PZ@>OAY/^Y'+JL-'@M$QE.G:2E$@O<!-7-&!0[WQ,R8F@5F22
MCA?B'4/\[;3Y]@P_>N;-X!?+3LR*QS[]('57679H2 N4&8JY8]8&Q_J0=&/=
MWGSV?@/0G970="C!#CV;.WBXR[@WQT02M9[(H!2Q+"02:;*.,\><7I'<^0@U
MN2:>K*;(3037M6OZT0^^P6#@OZ#A]^=P,>G'\=MAG.\!-E*:)2[*^HS(K%-E
MYZ:$ZJ UYS89TRZ%Z=['[&_7W$WT316Y53@/^-*?E!$C;X>I_ZV?+OQ@RE7P
M.J'+C#MXX*57"0CDJN6$.^Y VA@A53D76(GFZ6^NW0F[0MK1'5"EF\VTNTU)
MH/S:/__2W'H/VL#=X(!X=X[<CW>_.WB'FGZ(.Q74M _[\@!LRC+G C2^3PRQ
M"XZP4](D66LDSXS'7*42[%&P:HTW\7A(M8EV*I#I57\$$7]EOG7RZ%.P7!,G
M0)65RUG*%?!<YI!FYV@5KMR&L?] OJK6FLY$7H$ [\&71,YRT?UV>'XQ^8)_
M;_H2Z"B-TR:0Z*Q$YQH1!N83,4R[K!.C+%7I'+T.T/'X+)V(O$(+C%6XYGQO
M@ZRFA[(>VF&<D6Y4V((7.\A_3\9B81&-#"QE1B1GN&<"VD9GP!(/ IP)(KA0
M9>?8-S,><"CV38Q-Q+X'0KS^<0ZEZ<&KLHW",)7>)HL[)%PC>.!$T=(N5E%.
MK.*94,X8EU%$(=ND0.Q,D/40]^]V=*78!_C2D5:JE*BCA-'K/C\?].-T>YU5
M';Z\.+L83'-49YUQOHS\<%9_.'V9F 4(- ,15B4BG33$:Z"(.L3$0K3*5.F>
MM!W<X_%<]J"N"FV--D<]?P?;X*[I]6P+_# ^T3[(L3,?=]#LHS!_<_PA6>.M
MYB0&AEN$AM*SWR2B'( 1,:K$JWA;CXN1#_AB3XF0FRBTRC$0PAK!,,(+F'P'
M&'Z";S"\@+]?]%.97?1V.,/] G(S@N?#]#Q/8/2E.>]'3?7B),,YK90V))9.
MVC+BIF)] A(D>"63Q?55J:;M OS^?;_]4.7.V=.>]5R!JR_](%Y,)P7\/L1/
MO'<%2\B5"2@[5FZ(/3K5V3%B2^,[H-QP[2QP7ZFIS;:0?Q)>[DFG%1HM777_
MF;7$*/,IFF$I6Y_N)=FYR)/,Q*M(B4PE 5IB/&>\]BPY+>6JW*DN>MS<@^IX
MXI'NA%^AN>42IOE;T@94S9AB):K#! P=:F^Y/W5GHJ^P?ZT&QRU(Z80GX%0D
MTANTGD(RP@T3.5@-L<ZLCSWRX0%W?=]TV$3B%6CPO(G]M\-Y+^B/S6@JW\ED
MU \7DV(8OS2E&4LSG* 8\3-.%\TE%P=W2J4H01"=F"'2"B#>6EEFD&@=O;%2
MV!I\V0WV_MV9#G3?'$QQ-:K52LW_$-)K/QHBN$6%!Q,, ]V$4:X$BZ@L(\ZK
M3&C65"B;0=4YG5\-YQAHTH&@*[BKS]-_7\S[*KUI1A_@^XWV$*-FB%_&J0V>
M&5U)66("&$FN)&A27'J@*9 L&4W64NZ6BS4Z,C*;H#P>=[:><BH,[RQW52?Y
M>6JF<R'G[&Z#J6HFXPI0AW%N*^IR.>.L*T74R%5<A0V\$]I#)E&+3- 8<F*I
MHT2EX*7V"CVY*J.E]T>.!SS= W-C$_G7<'RO%HL>_S#Y41K_?I[0]T>U:>H6
MQ702T&QF3ZBSI7>ZSL1RS8G3+DGK3<ZQRLE)*W0'2%#<69'+>TWG6M@S5>05
M2)-R$JI4N 9;#A[1K0[HGJ&'51(E6,XV5_%=6Z$[<JILIX4:CNV]?&9SD#[X
MS*PM[8=%\;X%@HS&$D@\&>=<\JE*XD@K=$=.E>VT4*$\YUZ03,U!)J5RUN"(
MMARWW9*KAZ8ODDA5\"*!T:;*O,%6Z(Z=*EMIH4)*]"L(D[?#\61T4?RQ6?\B
M2(8JC-UQZ:7*/V. QV/I=VA4*LY8A#HE$G>@'$_@NZ.8*\Q-NHWH@S];Y&6V
MP54SPET'[#!1[JZ*NY<'.TJ]1IK,.GR:>IZ91%2R3#DP$8@K8\%IC C0:\>6
M^]$\138\$-;NBPR;"+OKBOV7S? ;C"9]M'B?8=C'Z+V9P)A3+A81D_ T,EEF
MPROT;1+UQ);F9R(8'W'92?@EMV%-T?Y#3]J_"]"-0II:TMR7JME5Q.,@@E,4
M][DRL=B@&^M%1 >%.2IP_8#ASTZJ9@>+(?>GZJVD62%^?-<,3R<P.BLKORK:
M"8);IHT@,FM*I!"*!!X0F,+X5C'-3:QBUE>!.1YO;V=1WU7_SE/+EC$M<MI:
MH*KI[:V&=1A?;W>U/<"#'61>P==;@RY&IX3UHK2KP9#7E71#(15)CG&T8)R%
ME)\Z$Q[P\_9%A$U$78$ -[:IA3>2H@LR,@*LG%LEI8LW"R1+X9)GR?LZ7OX=
M)/MW"+I0T7+RYD[R[;AU]\MR%@6C<S^:7!9W9\;I&!5XYTC6)?T##"N387'/
M,TQ'HSTWN4U!0ZNNW:L //TMOQ/1KE UW477G^!\/J#N^>D(IC>MRQ@76U$+
ME%UW[F^-;O^=_'?79+,O+71L'MJ#S9 YL)P)1('[(/>X!4KOB8D6;5AT0D&;
M/>(I4.6>SO\'8LHFPM]O+\?2>C#F8(G6TZQ/$W!KPS]2&WFF(HC,GU0OQXIZ
M:=_H<1.A=JWNY__J7S97!7%(;*H#B<#1"\)]D-@@/-&2<ZM8-G&YRF?=--GK
M#STZ56XKL*[[R;]L1N_]9-3_L<C'AL2%QV4$RM$JZ8Q.I\F>*'#1,Y.#6<X>
M67N*=^N#CTZ!NPBNPBW^FR)/>%?F3[]%/W5X6HX6GX_',!F_N'SO_[L9O1SX
M\2R%C@?N#,,PA='23(4:CL&IT(2YJ''9V0)4*9;8 ./3]_5K*V:%!=\YQK\'
MZS72&R]/&[PUSP,WQ'N8@\)J!&A/M,Z45^%<:5/8P0@K->Z.GLIRT))<:='$
M"6Z5-COC*-3IW_HHN/; 4>1CI=HF.JM1Y#4;*'+E"BP.V"AXDT30)%-6TGDA
M$Q^U)(G&X(4&D5J-H=N\RFLUGOT?8U;5X^H!9CLIH<:]1C^6EVMX>@<8, X1
M$CJ%%A+&YZ4T+7 $9IDP3M/$996ZC+6(CIL?W2BBPE7XBPM$!6@UX_]<]&\T
M1@K,9>[0%:1*<")3RL0YSC"(TUI;ZY-75:H!U^ Y'H^Y"X&OL!15B%"^1+HN
M^-\"84U_^$&$A_& .U%H"Y+LKHP*&\S#0'6VGCF*FY]T:-]L$,3I#,0FIKRP
M7,50I;7X@=CR@ ][&+)LHH/.,^M&E^.)'\QW.Q&2L,EXHJWS)4=4$$N%(\9D
M(S,8G53+C,F;'[M_WZ%CF3>="*QKU;V'B0]E#[QY(K]P;"E7P8,G97@&D;',
M+%0B$6\9]4X[)K5OI<A['G)4:NU*F!WZ@-.S9/1[Y[.Z'8\Y*T:4+^6?WEOB
M1?)$N$@]C32HW-UEYN*I3]^OVUZ(*U[7K0_*KU LJNY:X.@\F>'Z^?M/5]A2
M!<M*W$%\76<AW(##>%8@?2AWGXY(9Q2Q.E.BE3/!*)\MM&EE^3BT>$\F0;=*
MW$1J'2OO/4KJ[.)LT9\C1B:IT20#Q3U<&$,"9XDDQ65(&43T;<Y:6JGOUI/W
M?"VYK>R;+@37M0;]CQM E :*GC@GG)5[5!TM<<%)XB%G],XIIT%WIL&;3WZ"
M&MQ:<#4:!7SWHW0]EB5'YY.BQ =5YFPS@4;%<5(FDX9,C=6RREC.6RB>OL>S
MNW!7O*L[5V]__NI'@.N$5!J[H33\3*JCPNGI@>N+R^O?^>@OIW6+90G7ZQBF
MCP,_O%D!U6)1-8^\:BSJ0"VRMB?+<BKY8U%TC3*$&FL+3E =@1*(J33-#AA=
M9H\+I I "1$R;[-Y'3%Y'VKA];BYNXE^:[0X/CL?-)< GR=-_//D9L<0*Z/*
MG%J20PYE#)HG3F5+;.0Q9LC)B#IMCM<AVO^!TN$5OMP>N1-M5:#1/V%<^L-,
M7S&!WKU@3I/@0TD>CX98IQD),49T)@.+ #6(<P/#\;AIVPIVA8YWGLXUQS+G
M<1LT-;VK6V@.XQ9MK9S52MY!L/5>Z3DHI;-+W& LF024\L%(O+<:[8O4,NB<
M6*P2?>U!RP_X#W64O(D\N[X9FB.9#8LY&2[.#(2P.BI&"?/H%<ED!;$J.>)H
M0N_(. 6YW>W>ZL_?__:]@\2;;L5558-?OE\5:Y2D(Z,#43G@1D.9)[8,/,_9
M2,&]T9[FS35X]?G'H<'MQ%7A>&OA%\Z.S(/W/E$@+E&,2R(ZA,%$CTZBS"[2
M9(UP->SK31#'XS5M+=H5+^K.TX66_/\V<&KZ38_A/&E[_:Q1] ZRK> Z+:'B
MP5/0%DC45F%LQH $Y22AWBL??63<59EE]P@.7VHI>A.1=KWYX@;RY6MS,?;#
MLI=,0_&WPXC&J_\-"LS%+722)<<G$.?1-9#.,N*MMT3I2-&R^22D:[49MWO>
M_C?G7532U)5GA7?Z]^$(_*#_+TA_Q]6^:\;CD^';X3>83P?H,0,B>&-(MB$3
M:5,D0?)(1$Y&%0DD4>6<]@%<^Z/%NMW\77\(;R=P-NXY#< M+D&YTH(&Q4,L
MNE@D2_PN]3+%N+8'<9?B[SS3SD\N1OW)Y3Q"R/_HGWX=7+[K_\]%/WV&6'[6
MA_'\:K7GG)5.<D2J-5I!G@-&DYR2*#&@8!+%$MLYZ1L]]JGSH+*@*[CWA9U#
M_)7+/Q 6&LGOPQX#*DU@G 17ZMI2IB0$ST@V:"U+ TWEJC0JOPOEJ=.A(R%7
M*';_.&HP]$&.XLXU>3Y,95S9>;%1OX\A7PS>]3/T!"269+($G$Q$2NY) &9(
M*AT5G!!.U2G/:8'M6(C1M1HJ=*Q?D:X\FVVW&$/X=CR^@'0R*O\M(?$__>"B
ME+CU3X>0>E%0)J-S)') ?\NQ3"P3$L-E&I2-3E%1I09P-]C'PJ\]*N\N];:^
MR9G*Y,-%$=A)?ME,9SJ@7*;8/N%F.AG/8/<<95IQGHCFBF&HIH!8B9*"H'+,
M:$(9TZV<E!8/>^J4J"+4NTK?_1QJU$2 -'Z#\IA5/*.S] DBE!K:GA316@ZN
M'+>A,308H4\'A$@=O=(&T(UNTT%QFSUI/:JG3HWN17^7%UN/AYRU[1HUZ2).
MYA7PZ%B7P-N?0D_FX#QGFD#4BS0%&C/!.#L(C*:H2:J5!5CWA*>NV^[$U^%0
ME"FHD^]#&(V_]L_?#E^C-9I<OKA\U1]!Q+]R Z&.++EIZI/,HF2,9.)L ,*%
MQQB:!ZNH;:7@5H\["FUW+]@.^Z//6K>E-!6K'RR9F>*"_#[$)WSV QB'DJ_T
MOH]?31KT8GHV!BY *J*D\A@J*PR5(2N42&0V1)>M;L>%[9Y_%.38@^B[;*\[
MQ;S<^.3UC_/^:"J0V1%+CQGIJ.7(98R;2Z_P<LD=RA0Q ]Y*991KUW+OH2<=
M!04Z%6>73=2FZ-XT:*K\> +II1]_?3-HOH]?YXS6"YV01=3RR4]@;LIZS <5
M([HECD$L[0<="59F$GRF7)D0M&K7"'7#!Q\%%6H*NT8#D4\P04E!>NU'0XQ?
M,*Z-%V<7 T287J$&8G_2XPJ]5&D2,9F769#2DZ 8QJSHUV2*&QM-55(4'H;V
MU!E320E=EBC/[!M\@R$&M1";TYF$KS:R]S#YVESO:_-<Z*L01V5(/J'- R<U
MNL-,E*P=Q,ZS9SDGXW6[R]"M(3QUCNQ1 5T6>+6#_>5K?Y0^EO:W'YM1^?E)
M7KL23HV/4B/YRVAUZ9TBH1SRZX0^-]=*J>51#]M2:0-4/P>[:JFI1K)Z.8@;
M^3CYHS_Y^O("(9[!Z%W?A_X X[;;*_U7>3^2R5244)U.@[; \-5 \3E6=F;)
MA(,JI^F;P7SJ--N#<FID\,T1E=.[5<A?_XB#BU1RQ,=CP'_2%_^C!U8X(X)$
MWQ[* 5!Q]4V9O\RL-Z4) DM5[GJWP'HLK*JMIA74VOKP=8'Y TS>#B/"*RDM
M/8Y;,OK[@=AL, K(W)<FE8%0+@"T#%R**E46MU <"QVV%^T*1>\\IGKATV/
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MT&-I1HL%OI]-O^)L\?W]!=#RKF/JK\LR2>$3&ATC,ZYFYU1>@A>..4P^QB
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M)<B<F=6Y=D'6DOG"+3.B>#()DB*"?*KB'#1_[W@L?C1-[BC*/W8FX'RV&'V
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M\_SDI:P_XF)Q/0ND]HS#%%P,3'E.JZI)S"'3(JWA(0$';GR3_;+-<GYD%I\
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M5B9/HUKK2I*E"T:9D%%DK3*G6+9$E^@= RP0\TC1UR8[HK5WBFFDL!=\*A0
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MF(M0M",*6Z/H8"F*3CDPB,XA_=*:=.;3AP;09]?91+LHHSE)[B7S_CJ>IR5
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M.0<O739- L1[XN]U3IP ;EKU,HH=L7F?O;5>3C?U+GX=C^8U-:[A\C-.KN0
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MP]F<*OJ\5C@>$C>C-,3I'_@%+C],Q@FQUF3=*WELE\<?G#>V-R]K*6-)""R
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M5_^EO?S[L^N_^?75;I(D/]5_W5Q:IL<NE(]U?_K?OWSX3._Y X9I5E8XHVJ
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M)_G"W^.R<3%T'L+7><;^)V=W?.GXE/AQ(.3$Q01*!>O#)$8^I"P)<10(&I-
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MPN0_C-*JAJ"8FX+910K:(F4+X#F>8^T$MV=*+C[8M4/T"Y_W[LW!NVX.E!Q
M"C+)4?!Y'B<Z(>X!,I>#X_-<&9PG:SQLF([LZJY\R:_H/]9IP8\GQ);+@(=>
M'*IT@,1U()+:$!(?>Q!Q3FG@LSCFL4&G*]/QM;[3%VAPU0925CG]H\Y+_-85
M/4FEGFQZXS[4LLA?;(0QTYG:4Z2G)JTR/HUFW%2>JG+0@@9MX^$&-KC6(-=8
M$9HR95/W:8\]J;HS9>10PQG?/TRIM3J3E/4V=!E&%'/BQ) F!$F%I>K+8B>
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MBK^5VD[:]'*<+]*B?RVE^6/)4<"=NFRS$_L01=R#F"%IA_A1XE(D'$Q=PU)
MNF//[P!Q%_I_:Z.O#0OX:!.OIXQ&(7-DE72,1:!@@RUN\+M"#FKH%D/6C.FR
M6M=&>_!IZ].8<O*LSHSQ RY06K?\4;Z'][CDGXK\KL /36VUZ^Q]+E]/=\G]
M*/(\N5'B 8VD_>2&D#@D@'(;A0@5A B]\I F@\[-@*HQ@V(#&CPVJ!<JPBVM
MTW" 4,@'Z*YS_!NH+8NL3J&QP!8O^-01^FE#Z/M>0H=I*DV&K"NI<^-.KY\T
MF3BJFG3O-=-*-%]G5?&T_/GU,L:^0UP2RDV:5#<H\@DD,2702V(GC)T@C'PM
MG;-]Y-PTRJ\J*9.!OZ79'<L?]-3&#D']2F&8V"-_\K]^O/[R[BWXV_7'G]_>
M_'+Y=_U<R.=?;>=)::]5'VW4_4-]K]'.][KSO$F^QN?XNV_MR%^&]@RL5#?:
MZXRE7U.VQJNZS7(2L4!^3!0Z5$J/.(\@05)UA4$4>L(C$45&!4V.CC*W[ZT&
MJ0X MC"-FEOW4ZJW1E],U,A?Z ".!O3RZ^' ;N^^8P--W*NO1];GO?GZ+AX0
M-]0E,>7BS:99PH>F5\)MW2JA3J;9;H]1@D,A%U@8)K& * PHQ)%#8!#["8V$
MB C2J@,Y9/"Y:8O=!+"M *"5 #0B& 2CF,Y%OSX9F^&Q;7\=<MOD.J#CM+B<
M;X.(GQ%YGRC,QSK_9H$] PGLC>8Q?>9T(3P#I=V+VQGZC&%&8U>/^!-.F>I_
M$V+7Q80Q&+@H@ @Q 6/*8KDXB)#@Q/&9J[4NG'C^W%3_IF[XH\1G9AL>,J=G
M%5[ Q\B*>D.%@K8 [[[3U;INY_<&/Z857J7_U924JB]:@&WXX!6MI!&C&J3;
M,QQ/T&339#P<8E)C\81\AV;BJ<L&.H#7I.3_6,LUY]U7E5XMG])6H18H2#!Q
M0FD-(N7U12[$+HOD?P+D$!:&%!EUNCPYTMR^_RU04",%"NK 9O&GZ=5TZMH@
M;6QK;AA?YN[;<UQ8]=F>'&Q:1^TYF9]Y9\_>,$Q/O%Z7:<;+4MH?),UJ^_26
MT_PN4TO -9-#I2+%V[IR37XNN\I8=]XNUX*Z]P%G;]9%(6_8_0.M/5[EIZ:P
MP))1YD<H0C")DP0B)R(PP;$#7>2%U'6\T W=KBB<GO:9%+_6Q[E?5&YDG=8!
MW)1N4!'[F-)B+1?PU580,^TV[4NAIS'G-]'3:.%.;K C^ )L10>[LK=Y@5V%
M U:_#CMB@I: !6@IV/WC FS>II8&>SK^16;/YKHQK0"3KD4O,C>'Z]O+@+!1
M?^Q7^?76Q58Y4W$<:IREF^ D% Q#QQ-$[JP]!V*&,0PPBA+*DSCPP@'%3\\.
M/&"!FJ+JZ0Y2P%JHE]0C.T:YWBIBA\&IPE'WJI(MP"Z-;\_1>&&)LAYJQBM8
M=FS0%RQ?UL-!?S&SOANMF>EO\JQ,6>V8R;,O!<[*)C_=7<8^9[$3Q-+*#E7?
M+QQ#XC(71@%#/$GD]I]SDQV^R>!SV_3O 075%NG%%O%I_@<;M%98?1%[=)_F
M+QHTVS AS_(UL@5X>OR7-N#.,J-A?YU_AGGVWCMIQU5/[QYX<9=F=S\7^;?J
M7G5<Q-G34G"/A)[#(>,AA\@/!20A]Z$G(@?A",>4A[H9?#WCS$U#-5!!AQ4T
M8$&+5C^3KX_:?HUDD;"1E<] KHRR^C28N""SK^_IDV7W:8BXF^&G<_DPL^:6
M5UBJ'?8.%YE\=-GVB1=.S.,0>= A<0Q1@A*8!-R%<@LEJ(,]:=LD)@;,\6'F
MI@AV^BL"QD5*4\--T@DVXQC%D6I)+GPN-Z.NI#3Q$PP9B5WJ.JX?!KY96M+E
M?$[45KS%"3J@5OC4,^\NYVAD7?J,'/![@]'BT4X_"3:MLQ,C36J']4M[:'&=
MN7J@:TIM-Z6ZSM:<M:?V>:;*,:AJ#.\E8GG!8U[BU8TX>NEK+O*"7V<T?^!?
M\/<E37PW=AT,XS!,I":.*"2<.M!S0P<AYA,O,@H1L8QO;BJ\+E*B^OO@)@CK
M1@)=Y7=/*@F&K:ERMV<<D%H(D-92J&J'IN<SMF=9TW?V<G,WMJ=M!R[8X%V
MW9HSZG,'G81UO9D3-[6SV\BIBC5:=-&-,P-6'7J6(4[K_AN'WV?.PI&&&;9D
M?.25JG$K-=17N=MGKY]^+54_N::[DER8MB%?2\^+G"",I37NJH:YA$00!Q&#
MPHTQQZ' ON.;U*75']I(T4]0JU8B;RICKR5BE=*8=I@!/A\B=^D\\-@GV/<Y
M=)CG2HM>?HF)AWTHZK;H+D<)-BI\,M(\3+#@ONP\Z*V;X[ [\I*HB*WKEG>P
M 7D"KWYM6/X!;,"/$A%JSIC-)<Q@]$E7)W-6#A>> 4\8&FG>KDU7Z^H^+]+J
MJ4ZF<PEQ8L=W(*=A"%%(?(BQP-!%?AB$+L$A-?+K'!]F;CIJ:PF"#<Y!&8HG
M6-730I=S-;+&&4+3@%CS/A;LAIP?'6GBR/,^:9\'H/=>;=$A(<=X)P2GE<J*
M5(-J&KY+:68BGV$.72=R(!*>!^.$2>Y#S(@C5)6E(4V%K8*<:0S.]<;;T/5C
M5XX*MKN)S3L1;+@C!L^Q\'TFS5H*G3"4FPP<A)#XG@/]R*$.Y32BOG.QRVG4
MR9UP;:F7\E*=N<LM8>-*4M-ZIQP7M<=BAA-\@;=IBFE[(5^36O<:V91S:8#G
M:60WTZ74C^YD&@SPY5U,EW*KY6"Z>)"!?=?6924'*VY5&TFE>N[3Q^XDC;HQ
M9HY 4LM[#** (Q@CBN4_$0D1\^1J'AEV6SL]VOR.)SNPH-A%:]A@K8=>/45K
MB;*1U>:&JSV8(QQ9:M!AM6M:SW#3]DH[+_>S#FD:MUP6[EJ'^9>I>K@Z.;NN
M^$.YI Q[R,<^#$/"(?("U:,Q"6#DX0 )0:,@9D/"6X\--C=[;Q-]N0,6_%Z?
M*M9X#3T*O3SKJ0];[(VL/X83-SA0M8^1,0)3CX[W(H&H?9*?"CSMO>>"(JC7
M92FMF;?K(LWNFF*&=6_9W?'*I>_SB#@TA)1$H50IG@>QK^P2[F"'<<\-/:,F
M-=HCSTV_- A!6D-7YRDWOWP!>.>3>5765VCV_3:?"3VE,PJ_(VN@IC!J QHT
MJ-N2J(NF$76=@+F%;KD^J@E;UHND:@T^?:54$TZ.EDLU>L P)7;5)',W';)3
M7K;)C5<9^R@E;?ZQI$@JJ%#R[W%/A6F%"8QCED#?#PBFC,<A-CI8T1ET;JIK
M Q;DWU03V1Q4]VG!P",NS ^!M5C7TU6VN1Q93;5PP0:O/3UDPH1-%:0U[J3:
MQX2)0\5C=.] G\T*EV4J4EIOZV[$WW%1YUYW)8J:A("NGA#'<C?F!)"A,(+(
M]ZG<CHD0<BY?-=_S_9@;U1,R&7QN.JC#NJF=!1JT"[ OU<"J0T;SHNG]&8GM
MD;64/:+-'40#&+/J,3(9?UH7T@!FGOF4ACQCH)934F55X^6^3<L_7C^]YAF]
M?\#%'W5@1>A&7N"'#/HD"B *G1#BB'$881R[H?!=&@HCS79FP+EILSV\0 $&
M&[R# EC.,JZILRSR.+;;^@(*S363)B]6M=&Y,:?50)H,/-,ZNO<-J-9]Q?YS
M759U"^8O^15C]:X0KU29Q^NLK;?Y/B]X>I<UIAQ]JI.M&Y_Z]NZESWV!N$,@
M<ZD+4>1*0XN[(0Q<X?L1"1P6:[7.L(IJ;CJKQ0QH"[HI^="@!G@#VZ#BM+7Y
MZU=N+S8K8^\GMR*I/?E6J+KVK'(QMG(M0#=WG6A@1S9P]:)S9U!&_"7F<*+Z
MXA/.I5GE<=N<]Y8DMS;8=+7*;?.S5\3<^L,'+++=-N$65UR5)L@SY1)1)B47
MH>".'T+*$[EJAMB#B>NIFL>>S_R$^TBOX53_,'-;!C?[8X44;* :6>UGB-58
MSJS0-94G83RF#!8/*XQ-M!H,9,Y,LY\EI%=5G[Y[.MU[5H(]97K^ZH''2%F5
MLG2U5IV2/W-I'==I/DWA?\Y4&* :;5VU;I>N*,$G7M0G6E</=9%%@0,FL!=
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MP36I>K7)Y*$RMOILRV5HMT5G./*].,8A=#'U(:(QASCV$XB%P!Y# 4LXLE*
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MQMW8]V&4D%@J*!_#! D$8Q00WZ4\#'U7SX/2/G%^/H^_J7J]FC$A'2W]:F2
MJ"/KA;]=??Q\]?GR[_Q LNV'6W9?;LGICW?YUY_4E<U7JWXZ_%J[YTSR^1V
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MC3T_*;A1L-WR,EV?-L:\>6MC.GB];V74D=SDMS"NFX,=P@ G/7*O X[GPH?
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M)L#T=J-:^3MZ<L]#<K2 W901#M7 W-_!N4D_-Z*#/[3LH!,>_-:(#XS\H%;
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MBQ&/D%7&A#^$1_#Y1D78CB\OQBWTD4HK'[@Q:U(CX54#F<<V[J<@\-K!_>!
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M+R!.XDBS$2%QG$LBJ!Q>E7@[T/38IUSP\LDT^:OE \MMROTEE8=[T-I1C _
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M@W(KO_.Y\T7&LSZ3'LLDX<^K>];8ZG(%>MK4I]BU/L9,7[=F^F1AIB&'V3[
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MF#I%:)X<;FJ?_[$P>"^I$!W$=HS@#[C W' T=>"W3EB?D8M6J(P06-^-.(6
M]SWM+0/1]^\:>J9OPM2Y*0BWN-?_D*MOLNM;+))4%H@PF)K:;"B1&:0TE3#'
M3&4RQT)PQ^/XHV--C4AV1'4]YCZ.J.T)M1><@A\N]Z0$K9A!FD*?1</O*>[Q
MX48^@#VK]^NST_.W#.U^J*1^COBHESA:^G?+:EW]?;6LJEG"N<K2G,)8,051
MD>:0%*B N51I%JNH(-SIN.'H2%.CB+JG7ZF7>D9,P(V<KFT/CV%J1Q->D I,
M$DWCPPZD6D23M:^%]-GV\ P.?OL>'AMLY,:'9W1^W?GPW T#=O0_EY25\W+]
M\G&Y>K>LFT)KJJE/#&Y-AI/9%'FBBY=WJY=J3>?=OH3$+"9"0H0XUFY%I$QF
M =*T$4N<BE1&Q*JE_' 1ID8E6\'!O-6GE!6 H)7:8:-WF$DLMN.# QV8B3;R
MFV@UT$.\5@$T.H!6B:L.^2$1'\-,X+"U'MP4(^VDAS*)V[[Y16B>W"8?]N3Q
M=L4OTGQG$_RR)_G<"&N*#%\_KQ^6*Q,R^,M"/[&72V<:A%<?OLL5+RMYLRJY
MO#6'W;\\/<E5_;?/Y6.YGDF:*Q;%>M5;B!0BH2<JFG !8YQ*+'/"LLRI"T1(
M8:<VF]7B@3I-WH0<RU9^\&04J$)4*?%D]$LV]L8WY1MM"V[JJF]U!<]&V=T4
M]UI?$U3>&K]6&=2:7H'F#:G_ 6J]0V\P^K5.^.U)3_).8'/3+_)V6Z.>QQPV
M/1TX%[[=!+)_$GIZ+%5I<KBOJTJNJVO^[^=2K\^N%^+S=@E0GR1KY9H]G-XO
MNN5<VX5MEB9$JAAS6!"NYZLX*R!#B$+.]/_F14$RQF<+>6^.H>_LIZU1E; B
M/]*0WRM50FYA-%*"52.FVX0U[FM@-X--SZIO&8"U51WT=0>-\J#3OBX%W%,3
MM !L=KS[O[P"F[?F]LQ;XSS#O8GU?$YYXRHPZASX)K;9GQ3?1H@!VX?=H^[H
M]]X G_1LK<I%N=;3\#<M\&*MO^%R(^XLI9S%#"4P92*&2)D&?4F2PCR-9"PS
M0H@H'*:ZX9),=+[J+*RYI]PH .9& _V#3@673*YA=K+84PP'^UBG&RW)FY38
M'?K?Z@!K)<!6BW9B"8Z_PX9B<#N,M*$8Q!YNNXD707ER-W'8D\?;3;Q(\YW=
MQ,N>-*29F"G0V#RFG?#JG\Q(*IF*(JXG&(SUJDIA2&E40!IG3"F&21PE]LW"
M#@\RM=V[6BB7#E-'L+.@?P^(!";XI@!N(^+&T;\"OC!RZ;)U.59C==$:@IEC
M>ZS38)QN?W7DWA';6YV6?K=]U9EK!Y!=Z[BW2P+S+OQ4:G]PO5S(G^3Z82DV
M_VS+$>HKI6'<64RY2%.&8(24]KPU-4)&A( "IYSD.(HHM:?#P6),C3 W<H*V
ME2Y8M9(Z,,1PHUCP["A0!V;B5@?04^(*;*%O].C]H"O9>CNF+1SX?!2;C,3X
MP6SC-BM<#.G)>6/XT\>;62Y&8&?NN?QI(W<P::OE]CH,[Y57WSGSF2F5*8E5
M;HK;F@*9+(8410HF1+OW!"G"(S5[JGNR?%W3U?J2DW[OTKO0P+X. 7?8Z;P.
M]*1KP.1]N:AKART5:"1XHP8ECJ]%C#+.HXC (J?*I$U&D.1<_U%0B8@@4N5%
M^UI\6(@_^4O1:3#**R$7XL_V,EP2$O*FYGVCZ!"'?C.;^OD][0]TE-F-()E
M*YEA-IM$KQA'T2<0/A+,'MZZO0P<_L(R8#])6CVO:L'^6:X??EDLF<GV,:=Z
MGQ9/6I;=,HKZ7\\KDQ2DQ2^K>C_A3FM6*;T^_K18+S]K5V^>SC):X#C.%91)
M5D D<0H9S@6,I,RD*24@"CD@BB2LU!,]AJO+?>SO" !: 5.3N:1S_;/NMWI.
M7"S7LKW*H#&P.%F8M\)N#IR D<<O@M;3%?RAE05];4&C+MC5MPXX:30&M<I7
MS5XIV&AMSJ:6H-8;I &*IP4U4)"":V$D?ILB;4'1/UK8+>RHPR:S3PN^?)1W
M]+NL;F@I9K2(*1.80J87X!#A%$,:93F,(I$RJ41!&7*)N=][_M3VC6O!]&Q0
M6NY-'H/-CIXO ",PGS:2@0:.FU-P.%/>$:5]<M3^$*.2RA']]EG@V&4##H\^
M/#[-ER]2UM'4-VW7"1-/O:F.@J6*BB*)H"@B!E&4Q!"G(H=IFN=*16F,D571
M"+OAIO91=P*WR1"=R'4ZA,,1Q'F8+8Y]O((7F 1.X693B&8(A ZG-5ZA'.E4
MYE)(W0Y?K!$Z><AR_BGC':98:[1S:&)_UP6'(^S\/@7;WZ>H__A55B8WL\G)
MO&FJO])[.4-I6O X83 39L^;)P@RA#E,,RYSG*59RMRKAOF6<FI<W[3+^]8(
M"U9&VD%U=<.:UF$'^RT--OW]ZL;<K:IM<OH5V&KK>6LZE#&\;T1[%W3\;>=0
M6!_<9 XVV !W7J\,5E(/]EXV__VTV&;O]T)O9SEG7'OR"42YGAI07C#MU*<4
MXB(3D4G&2!R<>LM!IT;WAXNT.'BDMF!;N/8!( R_RJ\E!3]T,O_5M(SH@?HY
M**@.SGX <$=R^?V [.;X.Z)UTOVW?=9XBP!'[7:6 J[W#EL0M&'!FSV>#]_-
MQ"+;/FDS3DPX4\JAPFD!D4H5)&D10TJH$G',X@RGL_5R3>=VGOWIX9PX>S-H
MP#U6,\8F07>[TPA:>=T<]#-0VWG:_@ ,S-@'4&ME!3^TTGIL[6,'BT_G]<R(
MHWJA=MKONY.6=PWCE9]E^^#/=97/.*8DTC22,(0UC102$DD8C'G!F%*I%#QS
MH9&=IT^--;1P>MJLW_H?YB<[6%D@)W%"4TI2&"FA76>!4JB!Q-IUIG$J%944
MT]DWN6)+V\V5P=CU1_F3H,<R%5')&,QR8B)2>*[1DSG$G$@]<Z&4,^&R,37\
MO1MAA6&0^^0+.;O9:# >@2>?/A1U$SEPO5ZO2O:\KB,KUDMP0_V6F3Z(A,_Y
M9G> 4:>7@[KMSR:'+[KD:-\\Z*,6IG%[G[7G^^5)KNHU4/6C5,N5[)U,_E0N
MEJMR_?+)]*V7U?IZ(7:?\N'?S_K73>;!IX79=C4K*KVR0W%<J#2'DA.BIZ:8
M0DHEAF;KNDBY)E^WJ6E$V:<V\;5?'*OUZTA\K1T_V7@60P(5QGD)[-ANHJ8-
MO_72XU'##F"K.MCJWMF]T:A+V^KI=-5;"YBB"C]K]M$/TCK,S9,ZB'S';XQJ
M+_^Q(>.(_P9Q)Z/:Y7!,R[@B7-8Z0<O0)'(WN?\ICU.B5 *37.40Q1&#C!&E
MW5LAJ8CS@J1.%68/#S,U%]>A<L(9_.P8_W)4 I/S3LF:KFB"IUH)=B"$Z(ZP
M-]*;M$8XK.VQO@A'KA[VR>N'O=//+-?OZ&KUHFFH/L-[-,T>9WG*"TD3#O/,
MM$#@*84L9SGD"G.,2902E+M\]R?&FMK';UYQ7LL*>$]8-SHXA:T=)WA"+# Q
M&+ :,4%?SBO02.J/'2S@\$D1IX8;E2<L]-XG"YM;AC1&-T'V7]2-?GVZ,\([
ML\TQXVE,LS1-(:D[I1C68#EGL&!Y2F*2<I9;=7 ].<K46**6T^1$]24%O]6R
MN@2 'D75XGS=!U:!^2$X3"Z]OCW -5;W[D.P_<U7"^XS.)QNJGWLYA';9)^1
M?[?Q];F+A_E.__U,5YIFYB]-IZJ2SC\M--,^-@/([^L?M;B_SY*T(#RC&)(L
MTFY4&G--DE$*!1=YPI*("$5<W"B[8:?&E5^?'Q_IZL6\S[\LZ+.>F?1*8J,*
MV.@">LJXN5N6YK#SO/R#')ADST"IZ58+#6JI/3;)=8/)IW-F.?*H?IH;&OLN
MF^/=;IPE9#G[L%B7ZY=_ROG\_RZ6?RR^2EHM%U*8GH=R-8MEGF0B8E!&-(<H
MR5*("Y1 'JN$\RRF<6Q%4V='FAHS-<("(RVLQ06=O* 1V(Z&SB-\FGF\XA:8
M;/J0_>X$F37#6,.Q)96J8Y5*\K_=+[_]'_V,AE#T7_9YY/SS1Z$.:S4[MK"_
M86B07K5>/DK3&\U$;3<[U+=E]7O;_,^X+E$F,EBHE$*4,P1)7"B8H)A0EC,6
M,:=.VV?&FQI9=.*"'7F!$=@U0N\TSG9NBD?T E/&"> \MDETQ,5OD-[I(4>.
MTK/2_W68GMUM Q,"^8,4SW/Y15U_H^7<K, ^+E=?Z5Q^-44<ZA#CS^5"?EK+
MQVHF958(E!*--Q(0X4Q!EIF2"U&<XIR)*+-+Y!@T^M1HIVY.O97S"FQT@-I%
MA)76 OQFI >U^):[*L,,8\=,P> .?LKE"6GW7+HAB'G-D7,28-S<MR'8O,II
M&_20 ;OD[Y:KG^AZ57YOY_(<,:%204QCUJS)26/:B8*"LB*G1/(XMSI /_3P
MJ3'51CR'C=U]O"RVO2] (;2CTTDVI"'W/A(..]L7(#+2AK8#,FZ;V4=4/[F'
MO7_/>%O71Z3=V;$^=LT ,M(4)SFMUE*8.G\?Y\L_J@]*2;XNO\DNONB6KF6;
MICMC$L52<Q246:S]KD@*B"GE4(B"\()2+(5] JWCX%,CLXVLIAU9+2S0/G'=
M*UIM- /<U$]41K=!114&6<F"(@-B'YA"MY*#NC9E+?L5V%JC$Q\8^3>5#0+"
M[<## 6$?B:=]P^]&Y@/Q.TGVKL\<;S(8J.W.9#'T&0,+^QYO;';]N%RMR_]7
MOYYMAM^_)%W=:=O(&6>Y$@FC,*4X@4AI_Q>+'$%>D$(4>42U2^RRGA\HQ]2F
MF+ZL7?+"%4BB)':LK#O0+':K^1' #CVGG&RI6,>J;>WPH;.#T034JGBL;GL9
MEE[+U@X49=QZM)?A]:K0[(6/&]*T\:>[3PO^MW9-QV,4F\-6F!*9:2)$##(N
M"2R22"4X(VG"K,)J7S]Z:MRFA7-I/;B#DH6#.UCWP%2CY:KSC_XV9 =@%P67
MMHM#T1BKV:(]*HXM%@\I?KJQXLX=([93/"3I;A/%@U<$:DY5G6D4H?U*)<OU
M\\ITM+VI6^&<[$ CD$@)(BF4VL^#2% &:9(BR&3$4\[S(I>)6_V L55P^6S&
M*5'0*B!#-R'R_2Y8'A)-V+Z!)PF;,H^5;5^B'@RFBE8#Q)0Z% 6RXZBMBGSK
M,*V>18$LY-R\*)0<P^;07C.*NOE$_<Q?EW,M];Q.P*V]M!A+)EA,()&4FIK$
M F*"<YBBE$4BR5,E,Y>M#:M1I^;L;^5SFYKL(+:;3[P#%W@2Z#?EJ06^:I@9
M;&4.$!SEA))/BK4;>%1>=,)BG\S<;AZ:D\_TPZOUZKGI6ROD8TV$#?5],0UN
MZP\D2F0<99A#$M/8Q!APB#/&H"RPHDAA%E&G+!/+<:?&0EM!6R\(:%%=L_CM
M$+>CI  X!B:E.@)J*[+I M8)?=4#-0 Q.6+EMQR W= CUP=PPN-UP0"WV]T(
MJEJM9^],/K%<F3Z!+S_K5^KZ>UG-$!&")\QTU"%(_\$SB%/]MY0EG"E$E'X#
M;9CHV !3HYR^C, ("7XS8EIN^AV%\32]^  G,(\XXV+-%^>4/T$,^M8>*>A_
M[1/"T6>/\N6?TZS[Q,]>-RAJ<;_D\\OM<C[_V-0.F!5*I:DJ$A@AO;Y!18[T
M(H<6D*"$YU0@GDJKQBL68TWO"W]5E5S[Y49@T$KL%N-W$F>+@P]_Z 6G@!&!
M<XJ5] 7@:*&3PX%TC:6T@>9,:.7)1XP9:6FCRU[@I=4M@4YDCNU]]9NJ--Y;
M/(M%'&<9*Z"2*H$HD0*R3&"S_B,RI8K@7#HWPO(DW-0(?+?_U5,MI.<#%!?3
M>3H<"620"1Q\./6WNCEM3O^'&0-P'_6@PD6^:1U"#$#6^8!AR!C#Z/X#72WT
MPTP#K'K(]^7\V1Q3=%T]LUS((LXE5#0A$#%$(<&"PU0QGHM")$AE;N?E9T:<
MWO%V*^#V7!O0ND99]9]N]'P.ZA0)FF0%AY*P&"*4QY!&$D$1*\(0SU"!K,J3
M!0!ZE/31D6"VF]@\@A=XKNHD-7-,,R%=@0Y+GWUI'9'Q.9N<&W+4"<)2_WW.
MM[WMHK957_4:3UXOQ&=MQ?GKEDI94:@XU^XX):DF<\PB2',<PXCR7)&4IB)U
M<L>M1IT:S]32#NI4=09=.V+QCEGH[9&V;U4M,* + 6J11VI@90=3@#Y69P9^
MBW96=E@<Z6IE>?/@_B0'6O,96OMGN7[H"G9L-BMF*$$B*K0_&='"Y)I+S4,J
M26 14T(BIK*"<!<><AQ_:HRT*5J^DM_DXMF]+X@3^'8T%1#2P(1UHFNG$1_\
MH>4'G0)7VZU*KWTVAF#GN5>&DPAC][L8@L^!GA6#'C.,XW[Y^O>E7F\NZK7X
MO5SP4E;F\'I;EJ,KI%'$+,=(0I9B"E%!4LAHHIVL+"<TU6LXEEN=0;D./#56
MJV5] 6RY$)8=B)VAMJ.R$  &YK!?OH*MS* 3&NS5_0D0W>**E4_.LAY[5+)R
M162?I9SOO^#8IDEK8 45&=&KO)@3J;TKD4(B&(&JR(6,>!RGU+%%YO;AT]N=
M>[=\?%PN@"9[_CMXJ@-3+\]":8"DD: B41)RS'.(1))!FG&IW]LTPR1GB&5.
MV>##8!PG>" 8B [G2)-,?PF2AA(V0>2M4C?.)U5<DNY0'WWOY$W<FN.2.[EH
MO0$<YS*)!(-)FA/]N;(8LLB$ <FB4!E.)2;VP3\G!IK:Q_L7G/VM( ""O\11
M]+<4.T2KG(+S](?K$Z30&^0["66@EA-H08=D/I\"S"&VQQ-P(P7V# ?0+:S'
M I63,3VG[A\OH,="BYUH'IOK1P[E:3HW;L.RFRYN=P]TT2:X_;RL^SG*_;2V
MO^M'K]_3M?Q(R]6O=/ZLG2B4%4BD,>2YQ!"AN( T5RFD49H4#$E,539KHEV^
MKNEJ[>!*O;%J+E_JOH+A/M8OS^MJ31?"1)W0-6#ROER8@R=3#ZZ1(G"6]A@O
M581%3'F1PJ) 2B]Q8@(Q*3+(,IHJE2+"4]&^5!\6XG_S*]6I-]H+)1?B?]6K
MY+ ^^1.]'&.LC"Z+CVO;8O>0:?JT@K7&9ELU8 //@4H!-43 8 0,2*!&:0(Q
M=@%L/HG8/)]Z_3EB^@)8TELL8 C9AOF9M\VQ9=<Y?/\$YL-W/G\VTX<I8*;_
MSS0'GF5QQ#G#%.:$:K<PCA-($YG!)(]9%O&BX JY[*T-D&%JZ_B[Y9K.NS-@
MQR.3(2:PF_D" QMXHFJE!X83CAX!;W0 G1(FNL7?1'(!A#YY?X@8H]+T!3CM
ML^HECQI&@I_-$73U1?O"U$1G;\)-DP03@5@.BYAPB!@ED$1Y"E&6T5A2I:AT
M:E!^9)RID5D[4U5UN5ANO+;U4G,;EW5MT_ISK)[9O [4H/<KV=35<2.]8Y#;
M$9L'( .35R.A*:'5RA@DGO<,#CX9Z-A0H[+,&7WWF>3<Y>X%";[\L= ?X$/Y
M]'[Y2,O%#!6<8DT34$:I88A80(:)@@+GN(@S6>2Y=2V"O6=/C14VXH'?&@$=
M"A#LPW;Z*[\0C,!?M@,.3@4'CFA\::V!_<>.5F;@B#[]"@/'+AE:R:@)Q=3^
M0!<X5IHB;F8A5<]0LR(I)$TH-QN.2G^M@D.J,@K31)@ KR@2DLT6\EZOKRPW
M'L^.:?7BDN;%[8\<[OW="F="*W\M?]?,Z%K Z!S0=K.X'_#&*EK4QOF:V/F>
MM*;D\$9>GY6*+*'Q6Z/HW* C5R>RQ.!U72+;&P>'S.N%B'[ZK32JZ.?7^SZ;
M'^_&YU^O/TK];#HW8?S/VNPOV_OUYSZ36<9%BK')S<Q-EB:'+,L15)@P7!2X
MB*A3<4>OTDW-"3%?'UT#U<@,JD[HNFV2<^R]1RO:,=Z;V29TF$:O=8^1L&9)
M(R/85=38KM4);)3:OZ?NE?'LH]]/4-@]A_Q[%'#LA #_V!Y(%P@PR( 8MFLA
M2C,RG;>[5+?+%SI?OZR7U_S?S^5*RGK#_V$YUP^LNNY>F(H$%86 4@D"$6$1
MQ#%64*E$,47S(G+HSSE(A*GQ^%:);M,<K!HUP!-],9U3P1\/<@$>ROOF7%$/
M;C0RQ]?O7H3\#E=R;ISES>V/<@U^&- 8;YA%3]/].'8*S.D]$W4[\:T&9CNP
MTP'TE1C2*6\8_@[Q>L'M,%(D7Q![N 7Y703ER?"_84\>+S#P(LUW0@8O>])E
M.R/MM'ADVIQQ'"54808SJJ0I,Y] I@H)8Q6G#&<BP]BQQ+/-L%.;FEIIAVV)
MG$'8;5_$'VYC;8YTOGW/HP]89\ -IQ [)6=&?I/M$CLTCNV96-[MIV#5S7)>
M\I<[^7W]H];D]UDF\RCABL L23.(A-!^,L,(HCQ-42&2A")^6<&JO1%=OJ%Q
M4N+:+^>'S\NJ^NNV+-!E993V<;:C(8_8A=Y^.%!&J9$6_-;^UX@-:KD#EE,Z
M@E#(<DK[0[YI.:4C^I\KIW3LMJ'.SJK\1LUF5!<]<J<?U!X\*E+@(N.IJ=.&
M-<,0!%DJ398H2T1>8*8P=G-QC@\V-<=F*^LVFLKM*-<*8EL?QP]PP3V; 9@-
M<&3.@^'7?3DQWLA.RWG-7[LJ%O<,C8:M-Y5N3,G[]G46*4NS/*&:+!2#B$H*
M:5I$,"%)'$>4*D6<8L!>#S$UGF@E!+6( QGB )!VO' 9/('9P!&9 <&FQY3W
M&TOZ:I210T6/:?DZ$O3HE9><W!K?VD27OB\K7I=C?Y:B#1(SH?=R_47IE8_V
M3GZD5<EK%V5&9"(P41E,D[R *$9Z:8)P!FF<905C0F74J<#K8$FFQA;M@J6.
M"A4]-<!RH\=EF6;#;>9R)AO8$H&):7?56-NBKPC8:E)7@=2_>UI6=&Y.4XY<
M=P6TSN;W6NMZ&QG4BI]9C0X\F;T ?/^GL$.$>8,3UPLP.WRZ>LD#WZB!>)=^
M;]<R&F<RB9)4P#@5""*24XA3'D,N1$&PE$F.T,CMPYT4F-YF52?>6S</=WL/
M[*:%Z=HV\%SBM7'X!H0_9]OP03:<5--P-PVFE=D;Q#K>&X8/DV)XL]YM\<'K
M;[2<FUB9C\O55SJ7=^;O,RXX12(GD#%SB)+$^F\9%C"5,491(04GPK51[YDQ
MI[8FV:NU>04V4D.U7$'M^4KP6RVY\\;G>?QM]S^]HAI\&_1R0 =UZ[6$R'>G
MWG/#CMZEUQ*'0QUZ;6\=QD@F"7==M87J-UF<+$ZY*#B#!39UE#%)(.5<ORPR
MDHF(8IIQYN9J'QQG>AYQUW&!UN(Z=K\YC*4=GUR,3V &:>2[ AU (;)A3V+@
MDR(.#S0J*9S4=9\&3E]\Z3%KKXS)]4+\0XI[DVMKT@%JUC'["?-E]:S?IF:"
M%)%B4J(8Q@E-M8.2I) IS*'*,"(X19E43J5Y!TLR/;=E<]C8+ZUD=NQ:7<!6
M&=#39J@S,]2"KD>\ >TRWOFO9Y-<<$@\$,XP)\BNPKS1\?) S(Z?/0]]X,"M
M4M,"R SV136[M7I,LUY=R0>]9*W%J7_JYC0X/G5"W^5&\CHAI"]R%WL:PL$8
MB)?7#2%'$<;=T1F&SZLMF8&/&?9IW:R67$I1GWU\-47T]_9UQ S+@N8D0S"/
M3!P(1@IB%&%30$#E-(X5*YQV5,Z..#7'Q!P%/K5"M_5_ZFX#RUIN(#>;O&9>
M_/#UYL;-$3EO 3LZ\XIK8 *[V8&SEK;;-=]LAWOL.6T-C4^N.C_HJ.QDC<$^
M']G?.""C].?E6M[6M;6,F]!D/K]_EK\\+1=WJ_+^7CL<B_L/WTS2&Q%QGH@"
M09++!"*!!:19HM=1+,=)(D41I?9II/;C3HV-&EG-Q#]?TH5)?F,2K.03+05X
MUN(#_3Y4SX^/S:F5ODR5JVH-.'TJ39%&52[H@AO/7<\>BTI/(/HRAX1%!X.=
MIJV 9@A,7D9HL)6Z2]@'6G!@) =;T4$M>QAX'9) P\ \4N:G/[C=TCW=03N9
MX^GPN/$2.]UUW,GF''"[KS:MUYS7+=9OFGQY[2/KGZR>I>C5O)GAB FJBAAF
M&9,FHRJ&#+$(ICF71,\=25XXI70.$V-R,T@K\Z;6@/%;:2,V^/^Y>]OFQG$D
M7?2O(&(G]O1$&'WX I+ [B?7V]R*K2[[5KE[8J(_*/!J<T>6O*+D*N^OOP!?
M)$J6*( ":<X]<;;'99-$Y@/R02(SD3G?R7UI,U>K*;*S;8<'?N UXT1KU^U4
MW+:FHE:D76=KR ZO+D@.V^C52I(W[O?J@M;YMJ].3^M'G7<K*N17\VK6S9XD
MS](080+3.$LA0MJBIA'6I,A9$O*04AH(M^CDX1#3"TR6$@)SA1NIO0+/CJXN
M 61@(JJ0*&4;H GK*<5]\L:K,49EA%,:'G[K)Z_K]Q7_IOEBLRK=@I\73YOU
MM[SXYZ>5U!2B+099K$UEI_H5S5(BDX0J2$-S5B/&*<0R4E#&(5-AQ'G G YY
MV@\]-4/'2 J5*0N3U[+V*)3G@+P=.0R#Y\"TT1(:E%)? 2,W,(*#1O*JYIU_
M5G%'S"??.(P^*A.YHW+(43V><'F0X?UR/I>EU^E&F?UCL=M SA*]'R-2IC!A
M)75% N*T+ ::9C1",4]CV3?4T#'NU'AKZQW?[SI@G'PO3=2OJEP,%L8YLMIJ
MTC_RT#4M[O$'3V"/&H78R6SP+:5NN9V&"498X#142*)KZ#<+3%C@T16>L+F]
M1Y#"]!@WL0XZ_Y)S4P_HFTEQ+V9Q+*.(TP2&VLJ"*,QBR$QX-!8B"G :8A9;
M14:[!ID:-^W$!/-*3K J!75P<I_"TR)@X &E@4FE!5 M(OCF"R 'E[\'H$;R
M[[L#YN;'/X-$I]/^U+WC>>C/2+_GCC]W;0_JJ\LSE@WZZET.3WD6)#&"3#!F
MLD 8)&D<P3!1A+$P"U!B9:2=>/[4"*^6\*KJ\>GP$1^!SH+@+@-D8&[;QZ)/
M%_HCH#B0VF7@C,1GEB^,&XF=UKR3OX[<-AYUG99YC[4Z+NNWVWRW*?*%+ I-
MARQ?5 ?XJR)K,YQIXA)! J4I[XI4IC>8(E(PXB:#A+ L"KC+!O/T4%.CL492
MT!;5;;O8@:O=#M$/6@-SW%&@1JFG>!X>GWO!CM%&W?Z=U_IPQV=Q1S_B>#^G
M17&C_D[-\>?US:HTGUI-Y&<Q3\,H32B,8H[TAJ^LH1%&,&-92%$62A0[G=TY
M-^#42*06M #+G8S@EWQ1U;TH' M?G(7;CE5\@CCTWM"(:KQ+M;#Z[:SV.MI8
MV GLCU%LH?')*V?'')5=;!$XY!CK^WKLJ;8=.:L&G9\VZ\U*_I8O\L?-8]-\
M]L-&[OW^>]UQ]INQ7^?FS_GB9B&U,'<_EO^0=%7,%$LY5DA G@A3OYYED!(N
M81(I'.!,"('L]V7#R#@U/FLD!D_'>OXRN77 7X$01N#%Z."PV1EHHBUVD6\_
M?0,SZ:ZQ<--JN-(%U,J ;1=GK<>K/V[GO=;UJDPFU>N8UK=,P=(:@W],8[8=
MML=O/^LC;;'??/;=-N_#SDNG V"@H<=S(@R+W9XC8N"A>E@*'^K/Z7HA/B[6
M^?KE\T(M5]71#LO#KM;/F1"Y-^)6!^I*@4%+8IO#K3VQ="!;WYB.1)U[V,H*
MVWPG^:^>*,\%G4X"LWK0>'3DHM<>N3C=Z$85II?X;_2GH:/:I:ZH3'# 8YC*
ME$"$ @Y9H/^C) Y9&,122JMS#Z^>/#4#OA;.C@9>X]1-G1=I/S!%UG)Y3+8[
MJ6V'<T#?TW(,Z'\=.@5>/W243_6D+LTG>?J"'JOT7HG#;Z9PXL>Y:6[7Q$L5
M%AG&$M(L2B%2,H,D21A42+$@DB@5TBH?UV*LJ7V>?\&_)AC\^[_A* S_$_PE
M),FO)'18L\\@:V'Y^,-KX ]ZOP@L*$4%E:Q]XJQGD'.P<_PA.)*%<Q&2;E:.
M'3:=]LV91XQGV=CILF?36-[2L^8/?Y!B,Y<WRA0_62[,[JNIB/*J,U]99&C7
MX2V5E#(B4RA#G$#$,(8X0@G,,">!I H'D=,1B MDF1HE-ZHTE8,J9<R_6ETK
M:TT<ZYA?,&%VD9Z1IF%@IK>:@5=]0^N*:L-$GCT Z[7*TP7BC%OQZ7+<7E5_
M\O#(_M6U=V7=WB\7SW*USO4 U6 FK;#Z9:&7[T^2&B_8C =$I2$)(<L2K'>:
M$8<D#!6,F.(B95Q@YI10TT>(J5'L3D#P3.<;_:'K?X+U@P1/JWS!\R<Z![2L
ME>!>?MMY@NR8=6C8AW88F@+=._FO0$N#*[#3 ;2FIM;";\'NOACZKN#M+,?H
M);W[(G6LQG?O9[G[V4HKM]E$)4$6(!' #)EDPE@9%A04)A2E02P0I5%HZV5K
M/7=J=%9MH-P:(1Y"==[1UA. @8G%4G<G)]L132]UL;4?.9J#[8@>;??:L3_W
M3,NCQ8/YOX__L\GU@FHLHF]2?_&Y2=0P?[A>B/U?M*ZLFI(<5M[X^)//-R:/
M1__P8 0U1UT_*B7Y>A;&L5)!(J!,3('N)-$F#44,)DC_F2*:QA&=K9=K.K<S
M:<85WXD]MDH,]P69XIGYMOB-:!>_X5K5,@Q5_B!W2CNF$8[[>M@95-.=]($9
MTZBB[2\SHRV-KL!.V>J/9MX/?[=W0P4".%(XR?35JJ$ #195Z8$*#8_YDV\R
MBUZS,<?58-S<SC>9G5>9HF\CQ:5M*_::8LP(2QA1>KEC(I00981!S B!J0KC
MD)* I':F[)EQIF;:MOH;E"UK^G:0V ?3=LM],42#[ZJWZ)0B;MO7#-'5X2@(
MP_1LV!_JC3HR'-7W=+^%XY=?T@9\6V;^BYDEO3FN&]7'BD3ZL\?F4(LI\IZ%
M$&=*\T&($\93%*/ J=Q[YVA3(X3: [_KK]"(Z[C_M8/:CBB\ 3@P75R 7<_&
MV6<P\=\<^]2 ;]  ^XSNQYM<G[NI'Y_H+9XQ:VY7R^=<2/'NY?=":IOF\^)9
MFSU[;6&V>98JP"(*H@R*.*40T8A!&FO+0\4)803)F)/4K0:ENQ NG\XX52JW
MP@*ZE=:-;WI,A1T)#0OOP,QD?!#E!K,1W_1O_L5H /+%7\$.]E8SJR$:Z/0'
MT2>5]9!B5'[KC](AZ5WP)!\AU-_U.[E<K?/_E>)V)1_SS>,,8\08Y@PB8A)S
ML8HA#:($)@R%89I&&0TO")>^'G!J]E49J,N+8D/UJP#XLEB;(G=S6I^X,S'2
MI@#YB_YS'0 WN1%\%]D!0C_EDM#ID8GI$R:]#.ZQ0Z(M:4$M[E"QS]/ #!?G
M/#+F&\8T3R/0';_LN.^2O=Z795'7QUMHWMMHZJO/.IG*"7+UCA8Y+[N\SS*9
M,I:F(62":X+*,FG*"">0<\U3))%$Q)&;8>8HP12MLG)?\\M<J_#7JE0DWVH!
MEELUM$7Q_0/0_ZRJ(3@60W"=*)>]XR#@C[.;_.7+#O6=^& G?QDH *4*H-3!
M]R;3&3S_VTY[$=Y@(^J,S_&MJ?MC>I8BK@]RWBVO^?]L\I74UJ$>:/URJU^_
M\G26_NV3N62F$B2#A NH M,]AE$.28ICF')3: ''4430;"'OC?5BQX7V@UM]
MB:3Z$MLB#/=!WNH'/9ASL<8:>ZKEKDX1-D([5A^VGPD[LO.,[D@UB)N3ZMK\
MK<4&C=R:VXSD5]4YV+,HNU<B=@;,:S%B^]''K4?LC,JKDL3N3^B9&:,W4#?J
M;\NE,%V8O\O5<\YE\7TY%]>5&5F=[^$TBK/09+2@*("(9@IB&090!)K'8I70
M4%&GLE56PTYM[]F6S7!8OECK/YL-I6O"B1WJEHDBWK$<.L%#"USVX-L*YS'?
MP@D,KWD2=B./F]_@A,:KO 2WNWLZO+9]WJOS"G)1E(_]5OETC Q%:;4Q;3F(
MAA<=?<^7#3*A3V>G2'/VIU$%U+J 4IFK:B<#2WUVM6R&<$G[P=:K6^<RB<9U
M^GA![Y5+R,]3^[JPE5RMI+BC/ZN<@[^M],YL^\5F09!1G"J8"4DAXBJ#-"0"
M(G../48\C(23*=$]W-1,B$;:*ENH^ ]7)W0GM+8N:%^ #>Z KK$RQQDK4:]
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MH3DI(W%&,\<* I9#3V\#V\A[!4J)JX/8C<S@SU)J1W/'>A[LN&H(; <FJ\M
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M3'Z7S"#*]$\,L1#RF"9$H31V]-K:#3LU<FFD!BVQ'<-4EGC;,8U_% <FG&,
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MA5R]J_/5D6 HY#2&E D)49QP2(*00202A6E 0VQW[.K(LZ=&!+5TX)V#E_L
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M"UGH)__/)B_RJ@18LY76/Q6Y*$\\+!>W2W/2,:?SVM5:!LS7'Q?B1E5AH%E
M<4(,!3.5:!ZF*8(TC# 4(N:A(!Q'23Q[*J_]OJ:KM853U*-X+H1P*.2 #OW=
M>?^J$@6@:\#D?;XHL[\U8U2R.'CU?$YIA!B* YS )$!Z?X<E@S104G_&4C$5
MAR%/LGI*]6U3G]!&Q)&G4R[$FT^DA9?\C:9FX,6WT0JTU&K[=/<4 UO-0!-I
MJW+,UD!K!VY4G??P1I/HX(%_H\D<R3^_G53:FM16RRW>5O */&UGE=?Q]7)6
M#S]-7UG: V#?Z=_W.=YXWO\!4-J+#0SQ_!X&UA]TE5=;Z;74GX!^[%H;</_O
MANI=N![]62Y7^A_FE^6_/B_4<O58BO5E69AFF=Q\3O?2[,+UF'I)5HR$IO=M
M$IFF&5$6:'N+(I@()C-!49IA^S(.OJ6;G'M52VF*-)3"@5^H9@SSL1NI70Y\
M>I]$B^7X+:=FX#6Y40TTNH%*N2O04D]_8J"M(&AI> 7*B=TI"1HMWW)2'9;G
MMYS<D=;HMYADMW5ZJ$GH7*R]#SK>BCT47GO+]F"#]/-,OS?NF-4ZUQ)]U69"
M4>>8U4?3$Q4J'B,$(QR2J@\]02R&6- 0I4*Q6%FUT+,:;6IK:TM84$KKYD'N
M1M;.0^P-KX$7O%=0-3F< ]1LL\+$I^^V>\!1?;-6NA_Z7NUNZMG(1^\]UB_?
M38"M#+I]>OZ:SS!!H<AB C,5FJ0))"&F<0A%1E0D(YQFJ54AWJY!ID86K;K\
M^0+\D?]3[\,<&^,<@]*.)BX%:&!VJ,0#._FNP*<_X-?/'GO$= #@M:7+L7'&
M[<#2H>FKABE=U_8,9)\[=GCJU&$ER^=%L5Z5QGEQLWZ0J[L'NJ@;K_Q1!H4^
M+VI7("5",H4YC&-DZCI%$<0\1##E 18DD*EB8K:0]Z:/N67,>R31K3X\4GUX
M;04&W*E4 =E?RNXJMH6@1I]QRYCYE&9QI/"ZQ>GQSL/C5Z!FX);VH%2_*NA9
M W %ZA=%+V!GP@#N ?F1I\UK['XLV<<-\X\\(Z\R L8>_\(4X^NBD&7'^NX4
M,WW!UZ5IE]C*./N2+^3GM7PL9C*1(:(JADCJ335""$/"> :3,)(L9CS@TJD*
MBE?IIF92M[-1*_T 70B+Q%1S55O-*E,5_&DT!:6JCO50_+X$=@O=FTWMP*O9
MF\QJ_VQBG^@/DCGL1<"WR1+VB>W)C&"O@_1M1IZ;Z.OUT],\YU5$MER:WF\>
MRTSC9_E1*<G7=WKMJP*Y'Y:F5N-,X#3 &5%0AK'ID1&EVKQ3*4Q2A0,5Q"(+
MK>K:7BK(U%:&6@_04J2V6,%.%5#I G;*@#\K=1S9O_?TV1']&),R,*</-A\]
M.K1?!J;?;NX]91FY\_MEB+WN$G_A\_K4HA7_O:F<K\7=\EJ(\K%T?DMSO0UX
M3Y_R-9V;Z-G-XKM<K^?E]N)&M?SBW^4B7ZY*[_@,XS1*21! $@D&492&D$94
M0$4PQR(U@2_[H@<^)9L:"Y?1:U.T:BMY=0# .E+F?^XLTD[>:D8&IN"66J:N
MSDXQ8#0S+IU:MSKK0,_;][UY:X?P*A7?=BI=2NN^T92.57MW]*EU+-H[ /S=
M57U]#CABV=\!<-JO"SS$  /%B4Z6IZR=>'\K>V@W3KR_2W/80(IK+2F]E_L=
MWB6/I4*20Q%RT_<K)I P@:!,2$1H)GA,4\?CD>-)[\(WXQRF+&4WX:+?OW\P
MN:2@#!OYCAIYG']/@:.WF=,)Q(ZZ*P]?[<)#%0*[\- 5:%  -0R@P0&40(P8
M/_(_>Z.&D#R*/ZTHDO]Y<0XD#2!"SUQ+6CR8_S,1K&<Z-Z+M#L&:/UPOQ/XO
M6E?.:"1CA#B#DJ (HH2F$$<X@E01&M!8<<&%[5%%+Q*YT-QHYQ.UB%?5*2BY
MD_2J#!ZL=@?2RPMVQZ/L^UGZF4J4!2G-,(54,-.OC">0QG$(4QXI&2).8D+L
M#Q*_T62.<GK8;3KWSA6//:EV9LAHDS2P85'-3'F(]&-[9EI5'\H_FIDZ_%WK
M!H]IP3Z ]9HV?)% XZ85^\#N5=JQEX?VJ:M=U91N>D.FQF4;(L@PXA"Q*($8
M112R6&\7.6>I2*WZ#KQ^]-3\L;5P+B6D]Y"R<)[VUG]H-JK+B/?HT+B/@4LA
M[;Y8C%5*VQ83QW+:Q]3N+JB]=\>();6/2;I?5/OH%2-G1MOL0LH_?J!KN4UK
MF*6*4QXK!)/0Y)-EB3F:%:90\92F@28VH1+/7B^_&DS/\]6(#&GMS;@W0@.A
MI0;*I"T]&[EW/C%C95;-6985 @/[S#R_09[\9F_W5DS =^;1=59> @P88)<C
M-X$,[,OF<1*)V#U5F)8G;9CY\9:6?:$8_1;=._KS_4J*?/V>KE8OJJK5^55_
MTW4&5A HHH3,((FH@BBDVNY'&88JI#&141+%B5/3L3/C36U'H,4%E;R@+? 5
M,"+WS(8[![G=JN(1R(%7@0LQ=.9I2V1\\NJY(4?E04O]#WG+]K9^/'.[6FJK
M;OURJU^-]?6B/(/R9*CORS:K/Z0:W#@E$$L10D2R#+( I3!DBD4AD40QIU()
MYX><&MLT$E^!4N;2];>5^H+3%Q;@VY&.7T@'YAT/:#ISCSU /NG'8M11&<@>
MA4,2<KCS B<#.V^=L1/6V<UF7:SUFY0O[@],LV_2T*3^O:DA9UIS;.C\3JX>
MHQG.1)PFJ9ZV., 0I22%+)4I%&D<13P*".*BAZ-A7"VFZVS8[O^VLH.6\,!(
M;[:-_Y#4MC/B6[XL#CZ%Z;X _T)^A1821UP*IU\ISWZ%MYE+[[Z%D=48W[_P
M-O-TU,?P1J+T[XVV.W'>RIB]T^]@8?K6WJVHD><#?2EF$<6889E $K!,KY@!
MA8R'% 9Q&J0X$C%G3L?VG$:?VJ[@Z\8$5XRK?%T)"826TFTE<X/?;@T:#-2!
M5X^RD=U.\*MV=O\5V H/:NG!ARZT>[6X<T;-=^<[>P%&;XCGC,VQ/GGN#_$9
MLIP%2&GPF81"T@2B3!E/AFF!AX7IE8!%E! ?D<7IV>1E(Y+:XN(M27W$\2X*
MMTV(?TY9KT-'JL8+*$TA[N,6GKF0!UKGACXM5U_ECVO.EYNRE/SM:KG0/_(J
MD?KZ9U[,PB1$*D42IC&-366V&!*1F.JP+&(D"3.>Q2[6C=/H4[-NVF?SE#E7
M)W^ G?Q@7P'PIU'!T?OI-CEV)#,8Y -SCU>TG7FI%VH^Z<I-@%%9K!<VA^36
M[R$C>U(__GS*5ZVZ!K.4!G&H$@E1HK=\B)I^%5P*F BD:(!D&@;$A0^]238Y
MKC1" KF5TJEAE/]Y&]A5><EL3-\!N=-NF%*1/A&?A)OPE7#_&LZ_4YAZ<^F=
M'*!/&1C.5YNZG>0W^:0_EP<]7#%#(9<)%C&4D4A,D[\8TCB((68ICQF*E8R9
M?467XX-,C6QKC L@-M)4C6"KY3_EJK2:JMS5U59VEPH?)Q#NYE)?N UM7582
MUMUJ6S)Z ,BEFLGE0(U5F,09,,?"(MU(=-<(.7'OB.4^NJ7?K]QQYEHW,BQ6
MZ]EW/?DE\?Y-+N]7].DAYW1>;A$3R8,T%@)RD440!:;25293F*91(I5B2 16
M-6@[1YD:';;E<]J&=V/9S7O>$!J8^%S L?Z"K93O,,WT_2VS3/_KT"3K'F"4
M[]Q*Q^9#M[O81WRR:2WU30]6%=O+G^6N<]1,<!%)I9$,D,H@DH&") JEJ7"'
M*4FBC&,G#Y[3Z%-CAJV(8&6.7O1IH=AO%OJ$*3UB.W:8<MLES\A^!7:P[\0?
M*DQIB=IP8<IS KQAF-(2F^XPI>U#^I9/YBNIS:$/LOK?SXO:+UA\DUSFSZ:9
MU2R5,DY1J/1$< 01,SD73&"8:-LFTIL\FH;,K5^,S;!6']RHO5X:&4U3V%K(
M*["0:]>2QQ:0VQ&8-QC'*F5<B0E^:03^JTF_W,*Z$]IGT6)[B/P6*+88=^1B
MQ/9(O"X\['"OYS2PZL?">+%,G:APQK!"$B<$9B*+(2KK3P01@P(CO5/-5"@5
M]Y("=CCRU,RKT@[@6R'!DY&R=83ZHA/3]O/1Q]CRA/+8AM9>/MA.<-\5^9RQ
M&B4+[-7@T\@ .X6)=?;7R0?T)3(E5RO3)(DO'^4=_=EJCC%+1"@8B1-(,)40
MQ=(T*4HPC"3G,4&Q8F'8F%)W2U-3UO+C.CUF#SMJ-_)PW]97N0:B%ANLZ4\P
MWXGLRE0=@-N2TX7XC<5'-5[FX&Q+1%,#85EX344]CX=?SND8;V2:.:_Y:V:Q
MN.<R,M$/K9KMF)/]5?QO/E_^H%JG&<5,$B:$WH\1 5$J4DB)AEEA$2,414$B
MM^T\[US,HK-#]Z&6$>RBK:" -I*6P;D]NJ&E3OV8IFLVW CG4G#?@'<J>:_
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M[=O/'W=1/Z+9J[7[V#4].RS155F"__-"?QAZV:^\T+O8T>ZD8ZP82A#BD)
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M0RE0J$U+GD#*L@Q&F2 I#A@-F;UIZ4FHJ5'&KB/:4C5-T0I0:@;^HG4#M7+
M: >,>F!//[!3L$_;N@MGV,(B?8-Y&YC7/$Y9'S>"K[GKTX%PO#D<O2'A"'/9
MLTNA']#MFA9>.-8;]##T@\[QEH:>GMVWI0M;?UX4Z]6F.AM2Y4B8XR#?U^;H
M0[OP)X[#0,@4<IP$$*DXA2Q(&*0BX8$(4A)3[M:TQ7;HJ2VGV\0@_6D*K87>
MJ#9J]"IFVV,R[ SW82 >>.4S0H.=U%>[/"PC^!6H1/=:@[4_7GY;IEB//G)3
M%%=47K<]<7Y"/SJK.I??T9_?I%$NG^<E:7Y=&O>W\;BRN:S[K!P_S_M^6:QG
M/,"IRJCFMQ0S4VL@,(=",IADDBA.L(JPTVE:+U)-C03+;6!]-I[WKCS@9\+L
MV'#T:1B8*#\J)7E9>*#2K*S&6![,W5?P"NRIN.M9=:J\ 3"*7M5=L_VQJU?\
M?1*O'\%&Y62O6![2M=^'#QQB_":?ZJ.S8I9%022EZ4]5GBM.50AQG"+]3RI$
MDB8J"[<U>3T'&EMB6%'$_@GC@;FZ%A*LMD(.%,EJ3X;G0*(KP-,-)K8T&6$:
M!@HJ]IR."0<6;:9EN.#B$3R]!1C;SYYFD/&(]KT#C<>>Y;-.V;49YK[TP;Q[
MV5U2'UN__D%7HJH*5-3E/,WIDZ^;*E@1QYD, Z97)(8@4A)!F@4F8AE1$0J2
MX3CR4<7L AE=ON:13CSL1 1T#4SY&5,MOJI WJ\_M_^9M=N"O.EL#;P4GMQ-
MM-0S;73:U]4J@E+'_X^]=VUN'+?61O\*JG9JGTZ5,9L7D 223^[;I-_3T^[3
M[4YJ5W]0X6HSD25'E'K:^?4'X$6B+(D"*)#F5+VI2N*V26*M!^2#A85U::JJ
M%:;@T%9/O7LI-1VZ>)J'21B^M-HE0DZ@\)H'C.W*LOD8J-^:<<VYV347>BCS
MS#>;E:D-,0M)P$))4\ACHC3Q\P1B)C#$/$ JQEB$@2/Q'Q]H>NS=R D>*T'=
MB/H$G'9L>SE$0^\>&FQJ":] +:,_LNO&P"=CG1AI5-KIUO8Y=YRYNA\!?%JN
MY?/7-<F"$"4\@#0AJ?[Z50A)%ICF%"%5*$2*HL#%H7QDC*FYAZL<8%X)!QZ7
MJ](4T';;PLC>CPR.06O'!!<"-C -E-(-R $=VOLD@&/#C/KU=^CY_-/ONK2'
MP_)CSHTW]+V4Q6_Y7!;KY4(6="'JOK-EMF73F29,(A$S 466$HBXI@%,3%($
M(V%(5*!W@;%UO)K]N%/CAUIRH+3H5R8 IA:^S*-<EMFIJSHLPL%)YC /%N[)
M8= =F$P:8-^7P.[DOBJ1K46_JA. >T2&.4#LX'H<!NJ1O(U^(7?S,;H#U^E6
M='C<>)Y$=QWWG(<];N_3C:PL?/";7-\OQ:X04[GW++Y(+DV6?25)OKC;1G'-
M A5QL_^#24*87@28A%2O#Q!3GJ6,("2$L&]4UDN&J2T-E;R:_BN!P>-F56S,
M\=5Z"7[[> VHR6:L@JV<G'^73)/%:C$\^$/'$U1E4RH-6D5RZT !<T)2:7$%
MMGKL0E.'GP.7IFJ#S\58_=:&F1/'9FP7H=G=IZW?HT=LX7:1[OO=W2Y[E'MK
MK'IC\SXO.)W_KZ2K=POQEJ[EC.J%A<;<1$?P#*(XP1 CO:%3&1=2AEE,E%4H
M;]<@4UM5:CE!)2@PD@(M*C"RVK?+.@EI]P+A"ZB!5X!>&#FUT#H'P@6-M$X^
M>K1V6N>4:S?5.GOMBQY9R^+#HF[6:_QX'Q;K5:YIB9?]^V8DRA(9R;"J9XA2
MDW(G(@JSC&22"Z6"('B14^Q.L:=W-+*5#_PH^U4N%:BZW!= U@HY=K 99?I'
M/>KV-J5_O--O;=WEB[K3>ID%4;\LI>J3.PZWFJ@)GI!WR_U'/#2WFHF!SM'M
MQKXPN>-ZHTWHE:GB6U4M35!"12PY#&5J2D#$$I*4"\@S$5 L2) 2JQ3P<P--
MS:1MA?UO)>U9#O8DMG9D[P.Q@0FZ'UC]DQQ.(#%(WL+SL5XF%>&$QB>S"TY=
MW]/RY?=2;.;R1KW5_/.#FL287<Y9L:M<GYH@RX0(&-!40*1P $G "20(!8H+
MRC4&+FQA._#4V*.1VYB=95.XZNSMNB@V#[45^LU8*>LE>$/G?#,WF46M[NKZ
MMIW"CI5CK2?+TM8<8 J&MA=;Z.^$;N6]%N#[;1GR.DP#64?$O!INMF./:WPY
M(G)@0+G>WS-A/R^T0NM\L9':]))548!?-7U^7!;%S4+_^7%9T+F6XMB%G^3Z
M1AGJ95HPRM<SCL,T#=+(]"<(((I8!(G "DHLF!2<">%:1M^O@-/;M+?%UMOU
M6N[B+XZI_GZGT8XF7VYJ!B;3O3G9"GP%C&[@E='NSZ960Z-@R;DG;M%:FC\;
M,_%[HZE'WAUF"KQ6(? KX;B5"@9!]Z":P3"C^"C@\F:YT"Q8)NANZ\OHWQ62
M;\QZ=+NB(E_<O:5/13@+6<H#S"A$H7'EDE!3?YJ&IB9O0,.$,T[3_O5<'"29
MFF%<Y0$8%N [@<&ZDA@(+?(E95U<ILB2UL< ?F@&?U[TI:7&%=@5T&II FI5
MP-NN&;FP!DP/-(<K">,BS M6B.F!67?!F#X/'/GXK#K;;]G[9539[3U=U/[1
M7\O<U,8Y^@^9W]VOI;C6>M$[6?[1G/Z9[75UR()#3(E2&51)J-DY$Q2R*-1D
M+8,X3# )6.34.&PRFDV-[4L)M0WXZMO7MR:I%)0Q96/EDWI_;P8^G'O)MV'Z
M)WAUM%;;B5,%_:XU0+OSO0JC]N%>@Q.H@:HN*>,N6BZW"9SY#37_DS@8]*[<
M'^/T<*@Y]7;$.)B ?<*\ZW/.SZN<RR]&<E.BLTEXR%@:2T4A)PI#%"D)21:;
MB.Y(9#P5<1HX!'-WC#2U1?1/8?I+B  $?PJS7S!VB07NPK-[,?.*TL"+2R,F
M*.4$I:!5I=\>*3C=[Z!#E+0G[,:*A>Z/H6.\LP4NW5'-70\8,7;90H_]"&6;
M&WJ0YENIY&HEQ2W]^3&G+)_GZUP6[_-%OI9E^\GG??5F*DE"@H,$2AQ'$"51
M#&F2"9CA! LI8QG'45/)[=:24)VEL/H&]@NYW8X1]B'TMY:K7)I"5HW$+EF2
M[M-A0<3#H#N6]ZF2O73[MZ2_ I7\=8_4@_:>@V+N0.2#8C\2NWN? S?.[PUA
MYT+@_M3Q5H?>&N\M&?V?TC<(\(=^%Y>KIZKEZBY21"B.:484C#$R83T!@TS(
M$(I,1%02(@41;B?9IX::WIGT5E+7H+\36-HYD7S@,S"Q;T4<I_WR.43\!O^=
M&&ODX+]NC0^#_\Y<WY,5'A[UYMZL4C=JEUJGUU#*B4Q3!I,D"B"B-(:,9S&4
M*8E$DB@NB-,9YXEQIK8=;SD=U_+A<;FBJR>0;V4W1YOY5GKCA_Q[_J]\<>?(
M'B<PMR2/RY$<F#M:(-YN0=R)#<QIOS%/6M)[9))N>+P2R8FAQN61;GT/:.3,
MY2^3/+?OAOQUI5^0&2.)"!4.M3$B%$0L2R$AL;9-)%,\2%'$63QNKMP1*:=G
MT6Q/Y5ZDO.NQB1SX8,W/Y$S_B*SC$*S4=@)G7.>G8A*G51UB_C'.G<[C[#M)
MK6NH'F[--\N5,0O6\F^2BG]OZ,K8=E_IXFTN[Y9OKFN'/ LY#U5,89AQ!%$4
M4*AMT@3&"9(T-74AA7W!-ZLAIV:.;H4&]RVIH18;E')?@3?7#JXT.]@M7);>
MP1R8?G<XM@4&$.PAV>=$R0Y2!X^D=VA'\D+Z@MC-^>B$5J?#T>Y)XSD9G33;
M<RRZW7EISN"VE]:N]Y$>>K__49F.M7.2A3Q+.8TP3$+3>#ICB;;LA82)\3F0
MB*9*J'YYA.["3(WQV]EMMFW*^F80]I@Z2UM^I D9VFCO,1<CY1[VQW68?,0>
M\KQ0CF)_Y$[G+5[PS'[T>_J4Z%LAU6;^,5=RAH*499F,8<)-YX1(I9 EDD 5
MI")%,DBI(&X.%)MAI^<1J4]!Y^4IZ.[<'U C^!78E**#N9;=C4BM)L&.,'T#
M.S Q=IXK7X%*9O"Q"U%G[G.!R"?'68T[*I>Y(/&<LYSN[9M75YUKOU^N9'ZW
MV%)BW??RM5Q(E:]G.)8AERR&/$LH1(BD$-,@@%PDDB5I3-/4R0BT&W9JYEXM
MK6M:G!7"=M3C'[>!R6<;[E)+W#;(:J'!JUKLT][O'MEM+CCY366S&GGDO#47
M- Z3U)SN[N%@W$:L_R9IL5F5+L[?\_7]M\62%7+UPQAC5>F6?2M-_VNS6N6+
MN]>TR(LF+N=I^[BE>E/F)=]5R75%+NKDY%D2()FB)(1AENE-+68"LE $,!4B
M8RJC*N#8SMIZ&04F:+>9])UM?4>^%;M,+M[*[>"K&_^EL'"E3GJBA[8CMPE:
M5Z"E/C#Z@S8 39FEY^W9MR" $H6K;?CCT]6S@DL[,,";/\SKX^ VGO1K-)(+
M>LJODYM;^\5FL]-%/KY4X[G;7PSQ/=?]RTEQV5[/5&4I8Y3KCM(FPNL-7:V>
MU')E3I&+&0K"2(I$011'"422!% _,8&I3$0:8L1)2OIL]\Z./+4=7RUG&00'
MVI+VVP.>1]YM&^@5S[%V@F5ITE+J*W 27Z^53AS!&F([>'[P%]D16F-R:E-H
M_X >^\(;I7(NZ4)\D874M]Z_I[RDRH_T_RSG<[H]L4<\"X(@HU 08IH-QASB
MK&PVE68)BR/.260=>V([ZM2XJI*[+&ZZJB4'JA8=?J2@%-XQ!L5Z!BSV3D/@
M.C!GM2!MA :-U ""-JA]PE&LT7786@R!\D@[ J]HNYGPKJAU6M[6#QO/8';5
M;\_.=;YY:D6IWB]72N9K<XI2A43.%&$)2B,"21(SB!*<029I!#$/94RP#&.%
MFKQKR["6\:2W^G3W\[6'/QBI1!P[D+W'U%L&Q4QL.O\P@>^6M:%V;\PV,GX"
M(?'])V\2H?(]Q/]CA-#WGY?QBC.=%J'?<OA)KM_0XO[S:ODC%U*\?C)="CXL
MWN<+NN"F<Z*)82JST&=9EF(5*P)E) 5$(LD@-1NA-!188<&9Y'RV-HUJ[-8R
M^Z&=]D!; 88C,%/6FFO1P:M-47++G\%CK87A+=5H .A6!;>5RF%6A)969AC!
M*(XQ1 RGD$5$3TT4)"25&8VQ4VG+@69EC$K#S:R\V%S8+?K#(#SPFFW -5*#
MSRUP7WUK7O^M\.#Z/,S.*ZT[8CX72H?11UWGW%%YODSU>$*_5>9Z7DZR%,<7
MQCK&HRGF/HO32*H,&4=;F$*$> #U#PE,4D9P(L(@8,R%T]R&GQJOM<U@WC:7
M926W&YTY3H4=I0T'\,"TMA4<G-R4U,*WFUGX8[9^P/ED-T<)1F6X?N@\9[F>
M3^F3PGIO[/L/BUW/HO+4XGHA#H]?9S*+91(1!!')3%&^)( X50*&* F1- &O
M=FW#G4>>&K]5LIL=NMBU[BH#\4LG[;Q1 *AM\)=+,J;+G%B<+PR%],!$MP.Y
MU1_M>@OR5G:; MD7@NR2^#H0V&/EOWH$W3$'M@=PW:FP+@\<,2.VAY[[B;%]
M'M S0>M(($^QC=)ISN!P0D08(H@Y#K7IJS?VS+2$C\,H4G&"519FC@E:%L-.
M+]!W*Z!C_I4-QG8VK6_<!B;X$X&.13N"T=]Q9A^0O&9@V8P[;@:6 Q('&5@N
M]_8CG\JQ_)M<WR_%KL;7S>\+;>#=YX^?I7X-]7IX)V<A09F2(H2<QYE)$4T@
MC5@ &4,\Y!E.6>RT^;8>>6IVZ?7=W:H\UP3+1ECPBA: FL8V1F;'XT?[*; C
MJ$& '9BEZG.[2NA6L;\KL)4;[ 3WQU/.6/DD*_O!1V4L9TR>TY;[ _IQUT?-
MBM*T*?OP8%S[%3W6:[FDJ4PQ22"6F$ 4*&TO"8I@3)62610C2;B;O=0QVO3,
MI*VPIB#I5EHW7NJ"UXZ)/$$V,/?LL&J+.8!19 &'3WKI&FY40K'0^SF%V-SB
MKT5&8V9=BW]N*K*:I7&*N#*[K A'$*F(0QI@@W$<Z]=(A3(0GEIC'([>(\1J
MC)887^1ZM7R\SQ<MCQN@6ZDO[]-P9!XL/&]^87WQ7AB[W+'K8:&]O/7%91"_
M?,L+)ZB]=+HXC5B?#A='GO;BG2U.:VC3T:+C[J$Z=^_,T1OU=;WD_RK[,MVN
M\KL[;>C0+&$99WH=X'$ 42B8MB@EAY*JE"&",Y5:Y79XDF=J>^%20/!8M@I;
M5R*"]1+P.2V*7#V9]/M&02!,]VF]3S;N"Q.R><F>^=)IM;-?1YRLP=<;N\[?
M.WW,D78UNU4CN%JG,5N 6X$[;B/P;I$FU@[<"C_WIN!VC^U'UV^6#P]YU6;@
M>B&VB<A<KPUO\X+/E\8->LVT>)3;5BUR>N:$OMF6W.6QX)[D8"<Z^-X([W&O
MV@LTG]^BFP"C?GF]L'G^G?5[2$\G_\/C?/DDY5>Y^J$_U>/Q+I^6I:M.BC+@
MO+@U\=+MO[]9%NM/R_7_RK6I)W"WR/\C115J_GZYJG]EK@MG(@Q0B#F!A! &
M48PQI$HIF&B;+\VX$(PA-]_;N I,SYW7-%N&M.Y<_EC*;2((?K_/^;VVLXHU
MR(LR](^;L#5MA#$)5EM%'8\DQGUA+,\U)OL2#'TX4BL.:LU/QB1>@:WZ54*4
MJ7'0CEDTVNMKUN!)KL$.@*LZ!PJHY0JT0/!XSO(B<^?UL&9<#<8]\7F1V3DX
M-GH9*?IVR.0KXZ-^*ZO__[!HFNZ9A _"(TEXF$$:HP B',>0932"(>-$\90A
MRKE;@F_G>#W\Q0,O6+U[97:A:K=,7([46%TS*_G JT;2/YOUO"6LSY:9%ICX
M[9O9->#(S3,M=#_LH&ESTZ7],%YOBGPAB^*:_WN3%R4O%:^?6O\J"\'/XD2)
M,$,$IHGF$,0#"K'D H:<I2C *>7$*?+&58#).1U;O18:#4!;A2N3A-;Z1=UH
MP;(X2N]YLN.G(=$?F++\ W]!6PLW](9I96$IPPNUKW!#Z'3+"L?G]#B7?TZW
M^6*_'&'C@S3.26W$R;RL;D@7XA_4Y,ZO9ZF@.,5! $F0<=.77$**I(1$<$D(
MB1%1V/6X_E*A)GJ*OTL^:)WBZP]Z?2\/CVM66[V >=/J%L:E._+W2DO+H"(_
MTVP1#3#*K+VHA7A0778[9>4ISTZI<IIJM<:<)8? @C%G:Z1X@U%FS2T8P1?*
MG3$*%P\R7NB"+SSV(AJ\/=1'H,-'O6!_6,N'8A8%. NY2F$0<*I71F+62!9#
M05F6<8$3'#GV3CDZSM3V",\.O,%W(RDH177<!IP"MD\(02^XQ@T-L$/JPM/^
M QR&.\7?#?6"I_,'^G:?NA]>WM/3L&&%_/=&/_&=<5XTH?%12A*AR8 %QCF9
M101B%J4P#8C() NS.,R<W G'1ID:'^R$!*64CJZ HT!:[O<OA6?H3?TS9 8(
M?.^$P.O._.A XVZ_NW0]V&-W7MSOHZ_-B?H=C0C7*SV.8"B$A(@$$61)FD(D
M),WBE#*2";>S^+WG3_"HW&E;>ART+$B25 D"J8P81#11D BF_QES1'B4)2+&
M+@S9&[(QF'&7H56&$WB SXX7>X,R,!_6<@U @T<U]DE_^P.,2GM'=7M.=\<O
MNJ!>,SM?2I,]+Z59%\S\>W6*O!#OZI"9VZ7YU<UF7:SUIBQ?W#5!-]=5S,T7
M^4#SA?Z]B=4R05D;.K^5JX=P)E0D8AD@F-%,&U0BI1!SE< D,H49 IE)8=G.
M;7K*38_@:Q5!'>=BO"7MJ"?SZRO0J =J_<!60=#2$!@5#>O]KZ0K1\J;SA2Y
MU)2>A, 3(GL/):>W1:7_OGLAW[5>R+^7+V0+)J>WTW-9ZDG-O_>JU=/0;ORB
MUM/0^]0>9WH27A9%_47.RPBJ7=K:FRJC:29E@!.J4ABB6$%DWE2:1AGD,B0Q
MXU&2Q$XUE\^..+6]1'N&^T4<GP;7;I7S"MG BT\C*UQ5PNYGI];R^H_!/0O-
M$&&SIP=]D4C7LQB<"DX]?V./\(??Z'JSRM=/5:#JC?J;YK/YT\?\WYM<?#7E
MGLJ!?J,_\X?-PXS35,J8,QC)(-;;C9A!C ()92@3R7%(48:L"X0Z#3TUNFF$
M;](A3.MG4XO<F&#E#U*K\8/.95GO[*%2PN$DW&U>+((3!D-[8*;: EWG"=PH
M4(D.*MG!3GCPV\ P.T07# ;W2*$$1][O^PKV>05[L8.]?KM_\10RT NZSO@
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M[S(2K&"<1CA#:1#P)'7991P?9FJ["/U>D;U4XT(N\N4*+)9K<_"]D([9&2?
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M'):/<6=MI!5FM-ES6X_\8=VY9'D89KQ5S1\F>PN?Q\?V6!N_RKG\F3<]]+)
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M9''^AAX^D!.-W^IFB;O^;U]D(?63[V<Q0UR$(H%2I 0BSA6D!&G>$"RC3-&
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MRL_65X3IN=UV@N^=_T'PYNFM/!WCZ&="NNEG#)!'.@A\ N_-OG:'=:D J#0
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M09I$##(5QEF:))'^M:LK[N6G?GA/GN/$[WG[7GC*[9P$+SF) YNW[3ZY+>W
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M<H- $A21%":AJ24JM<W!(J2@"&5($LZ9B!RS[9Z-,+W]S+9P95U_V/4P;!]
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M<7:?B@W?"'7Q2M3%0U'O5SCA>4@B#E&:"AB%C*K-1(0A3K)<)HQD+.H*$?2
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MY<[+=T(*?ZY(.432 T/E4CJ?\;,C*YC2BB:2J3-$6D1W0(P3SS6%S**"J'I
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MYWKMP7@QO_S)W47X%.+V-3:7[W@QG\-B?L6J]LE9IQ'?7"HB*3#B0A(D1A;
M<TANVY'DX:S>)F.8"KIJF+BT,SW(?&_K\A5F87K@!G6;_HVMO&*#@\Q9!4\L
M6DEDPZ)_KVG)2%K&E/,L.5</.G>H&19!ARAX*U8.D743D'GIYZ>X;Y>_7O_W
MLOOJQ\C._,7BI9_-+G"C_9L?+V$DE7#)<T&HEZ$4]SCB)$]$:9-<MLHX6@5"
M.U'7 J0.PL&TMDJ:0-JG4W3=/L/L[.WD*\P7Q8[/1\E&;DM&*@##%:B9(<Z
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M!)GCECLRAV/H23BIG+#I!2=[2710+*PJETJU-,Q*'<&[+L)D#A]+*['Y2,K
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ML? K"%?E_LA$8B6Q(D)IY*L-VF(M&;%<9YZ59II7275O)V?8,[9Z]NE0R3>
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M-]^7/A/T]*> )N*U'^=ED-$5C^M^JJX<2Y<6<N YFG-:+E@+L$1KYX(/FLG
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ML--(*ZR!E\&1X-#XHO@(<>SG\RYW\0ZW)9?\XN3EVXV5P'CBRDY<"\*#<2"
M )>:X+Z(@K!*$>&"LBI:JO/1-X2#.&JDH=? 2^-XH&BGT'V+**XX AT@"8D<
M20<H9VN)=V"(RYQ'YBPSNE)O\@=I:N16_Q& VI=B>CMUJ)](.'GSZ?/)R__\
MZ\F[5Z\_?GK]__WQ]O/_[2V%L/7AM9('/^:D_[3!:N#RZ72,2V"^[NUPW:A5
MB=)G/)&<62QG]($$)3U).AH6A-9&5QD0N!-U/4_=!? I,5H&:3F):Z.TIP55
M/)40.4L8P]8Q6BU-W>T?%3^8P?L4H3?@&5Y1OY9(,;7326E^LIHNFHUBE.9
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M?AE7CN;:LW0)4HC,$V]*MP>7)/$0+(DQ>!]R,@RJN%%/HK*1<]G#8[IZNFD
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M+A642,<-/.%W=[%T**&-H&X/<$P'T-3 B'R(CTT[)Z.M]6!+KB8)(IU CU6
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M/0^MGHH:,%[EQ. DOTC352?^S2H"[X3VD$G4(A-<3YQ8ZBA1*7BI,217AM>
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M=6N)=1U%E<N=OZOU9K6_R4^U*/=R>7_YR^D7\EY>BJ>')^J_;KFUR\<M;0^
M.C+G\,\5S@B._^=QZN?=@E8Q_=\UN37J(8+R9L/.\MVEO"M;O(?+]='EN@'R
MS7TY=\8%AQ*X*:JV-'*$>\WJH&^KE!:!_($A-%,OU!^=U)$^8[ZJ=ZX_K[OW
M_).TQ%:@K[__%OXU7UQ7$BU??_^ 7VOIY>SB(UZLJ=AT/D_6^9!* JX3@M(A
M0C0"P7FK;&;$7#N(:N^!]G&SFD^/WP?Y'B<6?P,^"S&Z7EML[EX_3)?_?OW]
M9ERF#%;4^7_ 74U:22% D"Z"CC%XA4H(/<B-^S,TC9QW?VI\/*RW[458+>*N
M+F0[7D2&)$(NN3IWIH:<&J*V F0*'IWV*,L@&O09FL;%76]R?PE/!PJA!3QM
M-]Z#)5U/G;>TU;+V$'U- ZPST7Q6"&BE\<9S1H9BF$/09^EJ#%>'RO_!46=_
MPF@!6P^WWVN<I<\4#?Q[,RE+<-IXT8-ELC953Q22EAC)\3 4C)I"- V2ZO,2
M82/7#;5G+0\76Y,PO%[-]5@NVJ]<.P.LT$95R;&ZK31P&W7V0EN[.Y)L*!C>
M)ZPQ)7<4#%[$V!$R:0!CZQZBVTWZ.ZZN]75 Z9DUM/=<J*W4,P1'*V'2)H6)
M)^2#&,]'J6D-3<<(?#?^/)K[(T)HN5A-[FOU]>[2I**CSPZ*K8.UA#;@2U7C
MS LN:FF;[-*YGIY^!S?TTRYF'G_]R+6'(UG 'D0Q,I#JL,EWY=X:MOL+160F
M10=)*]H-R"($'P@):)+!*+0N72I0.N'I22K&T4%]B'7>-X_'S@C<GJR_VBI+
M8TNRA17@2EM0.6@(H1B0)H;D4<A27KRC>.2YXPF\)RG-^V%9(])^?3.-7B&/
M.H#(!'AE>8' 0@:L@\A#Y#RYN(^T7X\YPGU8:1_"LD:D_69+>BE:1*5HX=PR
M4+X"U3I96W+Y8A47HO!]I/UF#VGW[B,,*^U#6-9 ^/' 3;K'F]L<@)!J29@F
MKUI$<HK0D\FK5>/(N7'%&/*7PQ !24?Z1J[\'_G<90@A-H#-!Y'?;<4/GQ0T
M.23F0/I23S1E =IK-4O.R6A=SEB&:D+[)%'C!LJ#H."ETY=#1?+#)O#$[Q_G
M5\23<3-V=JEH(T7G6=XTE9.CLG=*"P4<"WGH%<4N>@E&LU!('R<9!NFSV$1.
MSD_39;BX6.#%]E5;Z6WL5(G>9VX]N3:VMI0V'IR1M5C<I5P3!-$,,A?Q.:)^
MA"R:?1#W2#N ?@0V\AG4=NK?N\5'7'R;ILUUNW5:,",C>&EKL*P8..4=<!83
MXTC1D^CM^.DQ L8%5W^BG??(YS9PLJ0-MEW!<AO%T2)TD#X">J18V[L$KG:V
MR()YH12GYW1)9-D'+ ^I&._HZGC!/D3)D5P>^T3C-]*TBZIRZTW/F_!U14[,
MY396=P6U+\I!")XVD7268GY=0+A45"UY4+O-[YXXWGCF):.#X5CYS0=@YMB@
M>$O,F"WQ%\3E[>3&4,WU9O^L/N/B^JP6362IEE?[E"JO:!]I(R$P9S,ZKB/O
M-GZG^SO'.PP= #(#L;HE!&TOC:/ES#@&(A%?5#W*\<IGB"%E%"%%-&QOH(RH
M0@:5WE,(V9^58P/ASI2H#>TI&RD8UKY'NC;5Y.!SB<"BR44$)DT2W6S*_0>/
MHQ1.!H)CV#@V!![E#ZG0-6,>85*()3CN.:0<&"A$LI0R,8A6<^%0( 9[N$EY
M^L7C7+N,HD?Z%D,#I^%/1(*WY[J.V1BLJ+W7?&WG*Q1$HRRX4C09:*],&"2)
M_R7"QLV)[3V 'D0>#>#KD$%>-H?,C<N PJ?J\SLRU)8VK%!DP976#@=)4QQL
M^-J)47@@6'H8P;:/Y'Z\NYHZ!0,7]21V:S0VO=%'NK-Y@9J1[V[VX553=SB:
M8E,I>+U,UW5BL!% NPPA:.V%T4RF'(=03DW<X=RF)-!+IBO2--]JWX55F%W4
M9EU5%5QG'H18FRNP LPS4CU,DQ\4L4!$;ZSASFDV</GT2R3^"/<[^Z#QZ2KI
M7H79@-/QS'JN,V<NPW*3=<L"U@&0#'2L0Y5C(1/I X6$* Q:&X4S@_1)V(/&
M5HJE^X7)_#0R:QN.MPNK.83;4U%>'!*W#"2M!2B5%?A$/^JL@C9>,I$':::V
M)YWCPG(PO'3'Y='":P";&^^KNO$41VR,R_8@0U.TZH/C0/^IC9-R N\*K8M;
MRVFG1ST,"I^DJ%F\'8^#^1!"&?DZ_4WU^'%!W%U]KWQ9[T0N*.CDD2R$Y&0A
M8DP079W6+:-"RPI3L4N%=:>;],<(:*62>A!3V@O71T;-!_QZM4B?PQ)OL+^[
MI.T&2PP9!EI*XI$VF$<% =?[ 3$JEBVQJ"\H=:9JO'OYXP4_'UH*8]^HO/K?
MZ?=YF.4W\\5O8;68_GE]-Q"56 M=\L)!F90@>,>@..:M8$713NQT<_+$"\8#
MQ4!RG/?,U+&!\3Y<?L/+R_#I,R["5[Q:3=/RUUG:KH1IXV2@R%HS0UN'##MX
M#,2I@BX%SE&K;KD:S[YFO/2,$X"D/P:/#96/>(FD6:^SD[@3.:1<F\\K4+E(
M\/0+,+*$4G(4&+I!X]YCQRMD.P$4#F=@ ]'2,V[;[:4+J3=CM5) 2_#DH[L
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MB(9;T+0N-"HX-HR9[DYB-\R=U67(P')J (&_?OE*:UA?$I;;2&LYR0&#T4*
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M$;D$R:++Z+S5;I#LW!<I:T.5'27_#I@Z7!ACWUC^ Q>S<#E=;HN&3'3&H!=
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MXQ'Q@VV1]XOY5URLOK^_#,2.S7G%UW5%/7<)M8H1M*VY=A73P7$+%I.+T?.
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MCQ%5HXBKWR[PNOF:UR8[7A!8EKI64 CP/B-@$@*MD3*$DV'O'F7CHK 7^7?
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M.H#SWH*6FB59@LVER9WZKH2.?)O5#C-W-UZV5.#^ *T=P,< :$IGIV<G=:[
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MM!? 79:V$*O%'/MFYS%ZM[N(9O\DK.ZLQF>)UK?SL\4DR(1"E$SR3"19BH>
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M_-0X:^1'!FP#+3SG=YX_PM_3T[/3VQ?Y=/9=2FAB467*T"PDKNL:6<W I6+
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MTU[OCEY^.A\,0W_P=?[F[W ZG9T/V<#5V6*V_#P_.7E[7FTR24SH>G<)//)
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M)UL;%2=YQ4F&"9Q$/,"&^7=%>0 1S&"7SZJ961P05+@$?*G=(*&W"<$-'\L
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M<RK@&L[## VKOL7>ADYI_3_O0ZG5#IYWT*2@ROLT65ZDW3+D=)"F31'Z>$P
MR9/@PD2^/I05V@K$TL/UK!K)R;'X:04#">9@Z]3ZB_&7,3*86MJR%?<?D%3;
M&]C)4*JT>U+F_;L^S9.K4:BE+:BC'S6DRW3+BW8[9&KL/981NAKP V0UQH;D
MV/LB7@O@SZEKN=!]Y$U/=M.#\&&*XH>?H%HW9\9'D%,SRB<J!GE0UL,0%O,O
MF-Y1"SXJ0$@#VQ+>-C!$'Z\H*:S.F1.4@A]<F_+SI]$(J:?GY63 DN^<C#-=
M;?HT60X:9IH=U<@)N5F)[:BS6GK9-JIA4&23\D'DLA:T8:QI+*FFR;3ZZ6[=
M(XI"+'3(GMJKT+]G<YR@6A^@8&].Y+%"MRZA\,^#*N0^QJ8T$AX[A<)P\9<B
MN</@TG2&'V:QQ(=]A'5)9'PG^9\X+T<O7TVQ_5"C95'Q$>-F5%"&O6P5$>^N
M+MK!1*5[1]>4*#2-9MU79?9)>7\ZTDR:#5TLQ)R3.,X#&*'.WM8&:?!\,[]G
MGI[M^F=>!R8TF[&IJL'_F05HLF32\S"&9GX><^,;O[>KI;HL6F/NR=8_Z,DX
MIKV9D5Z)<=@U/1E)KZ:E=L[W!P]SB];74*NSD]87:?D^S58-F2^X'XTU1] =
M^\O7+T>OOOGF&_COR:M0(\V\7O=QA?&H?U<**;/'E<70X5W)344HELH->W^B
MD7;H39:+.3U"X\#V4&#,)4D-CHC!=6#DH#'HZN7U&+OSP#":W#3,2=&&3"C3
M5]!CV$Y#HP$D6,6V(%8>.O 8XE*#7^ 61:S(W]YW>#F$ZU74#1B-O+E*-9,V
MYAP+F>B.P)\-S]$!S?PR;OVGWVDK)X[!O/^B_]OZ\?<'T_%_NS[+-8D57,@<
M#V:]=Z1NWH6X:7?"LQG&J+A(<:)  ()@F@OL<6EPIBA6$-G)SL5A$-0Z"[NZ
M)GM+#4/M2 Y0?S']0.KY#<[*9Q = [A^%;C^K#[A/0'7#W;S9[2;AR:D.V<W
MZUJ,/LW5@/';9*J\AO:V3^7R!!97I!3MRIP]T7-24U,LU)-I-]6]KON:UP!<
M>AA%;C=*_5]=;9_NA49U,%[=S&L%3[IK?FK*C.KL9VC;Z!J@@AFNMK9P]*SO
M%.(UHZZY,CU=PV":/<@>=7_47K(I1/,*CCC8+XEC;MW9<H5LVC\M C#89,*N
MM%U_6[(FO>HM]O3AGA&A3"9Y-O,+0)E8;N/#K0D^VK6B^M0O:\6K*0+T[U:T
MS<7BL7W[=IGQU[TN7GNJ=H'+1'AOS2^F\$J;R,&+-1&>Z0&<VWG$! O5M<E/
ML"P%&-3!6!3*5H!D>:Q2+%ES<0B_?P4\S96*J5]M8T.W#'OR\.XPM*DI6VOG
MIATS668!*>'C?4$-SL"U(/3TG??5DXC>]E1?')X,G"J[:H7V3,FOQAQS'\")
M2I61*_HMAL._/0]T(/[8O;.?(4:A3U,U5!O4HDU_>E1GPY$-M><[=]9_5(DL
M2J2O>2\6/>QIO-&Q/ST\?@K'OJ=;Z&2H*]^Y8_^VIT2J@G[+G*D,5* #SOE)
MFY1\?7EN"8PTWB(F%AMA>( FAL?'H1T:U$(-K@J$:Y2%*5(.\*9P'XQ9M$B"
M!DFS-4DSE"_OGJ0!A8V<4'WS)Y8Q!V)NP"<,A.$5R->.7 LH;2*I[N56X+)K
M)YO$32RCC&FFO^,Z(KRL;UNV1J[8B)!C#-=Q)Y)4;W/;:2ZV1['&M3-M%,2F
M0@)BY:![PDI3_ZX5H\.+S0CW0R:33*-:AY5.6K001E^P.3O)DB1[H#H!B4,G
M\+X+UG,#FY+5#W7HXVHS_%$'NH8F@8;/(?#.&]%%WM-$S@C "/8+4]W1;9&,
MBN^B<RJY9)+ ))<B7L!C)YB10. 0JFM[0\Z8X/-4>I_![,1($!7)OWQ]]N)5
M0.F;6!41'Z.]^M#P_O-<WJNL*AQ5E'VSYN'#.9^"'I4'N'6#.3LN^MUS.<:%
MXD0<YFPBF#S%"3Z:/WQ5WE>QF(D[>,Y=1J4JN?R%_0GZ=P07%\RM5U9YVMIL
M^@'1/KPX[6TJO:ERO'T8S+.B%%C@0LLQ5?,YKC6/6C]<)O N^:)YW["Y; Z4
M-58)FD&Z\Y">9CV.>#\HQ2=BW0)+(YNQ21-75#J8P-32#V$\XR++QY@!](MW
M;)<F?6\B:&P-#!<\1D-&6UMZJO6T3[A4J&-EA;)P5O_XX<^RM'N?+G\7LQ]A
MTF=CS#'%YO>P#ZA*!F_.V%SO?!/?-M:(\JU=)Z(]N:^AMPQ+,\7I(DTQZS9!
M(82@7Z[)M/V(CHY>=';,Q'PR%;+#K)7Z8GP,B! \9FB(7N KZ Y1QT>CHV#O
M?34^#-X<!F^SPV T&AV<OMBW@H9SUS0,KY46?E.G@3P,@FL_D:9(GL3!*E$+
ML^HDK2F&Q:0C(I"5R'&^^0061!=4&E*WNU3RSZ/L "SN&;QJ7F"Y;!!GO.8F
MCTKU2^(C3+LJF3+4;J>;;"$26E-B1QHSN)IV!!;(DC2FI<4B7+=QZ ?P)$9&
MP\7KGV7?C5ZF_H(P;]9$<0.1> GBFY>)R#5>0,^,_@X5_'-3AQB-ZFTA(\AA
M#G0#X-";+,[1MV9+7WD8//()PFM%2WL>3N7&SQU3Q1S(T]+@X?7-2&246I<9
MT<929(;5/; 9,O<0N#+GDS%!X3%%@MKF9L!,>BISC]V0=T6K,KWM@IK#9B_1
M99+,P"J2J-*HDO8@M#4#6I+4@1947<_D [OBH4:RJ52D3(&-DHM4Z!>[V\^=
M*-" @IP51UVN*"I\2+7<IM?? J,OV#=FM(68S<FL0]-!4=7M0"2^"=;Y67V:
M>H)U[O]!06V*5D9!5(.@V)FQVWW:R2(=-OBC+55VI1%X(J5V)W>Z(@E_Y)-,
M]Q8P-X;W";#FH9<.?\^\>H_1G57:IJ"XFAV*/T2/+)@(%(WCJH G%4:.6B^P
ML#SDK U5ZFP-[*)E*NI48;QND6IJ=_C)'=*8%V2"D_?'<08G=GV^<XU ).UO
MK9 A"KR]*/! :K=[46 PG*ZP)(W"9.3_]VG>-DTT/SL\?AH(DYYNH].!:6[G
MCGZSTJ)/DS84-FU>V&0+,#3=T5P7SN#?FFM N)1]P=;7!?(6>(:53K-[Q0BA
M[C!#^1')C>69.R'+R[7\?7+M,&IR'/QL"6[(I^![CLR;F@[>FL$-5U:,A1<*
M7W?_6!91KL9L'A;5N-"J J9KH#K?IJH8"/MV4%5XQ[!/,V;Q22@$UTB$T*9N
M#)B(DIXRQ\1489S3D&4/R%'3+8%X^)#V3:65N5/M3Q 7!W@/KTB,4\FYO,M
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MSAD-_X.]6R?(M/&::ZM!K5S=]X]3T80%@^OW[TB_IT1#/\M M6..$13,Q+Q
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MM"A@+A3@$Q+#+:QC!+H;'@5.I;^:GLS$B^*,D@7@F55)::F]; L0^D3$[ :
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M2=UKP@); ES88NAN"@83J%IC^=5*B@FSH?LC6%:$956[Q[IJ]T0WIM;&3-,
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MI$CP1^$33B ''J/CR90)@U*52%IDV'!SA*FKU #4<O_L>*UHTQ09<]_*,OA
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MW9_?@8:E&[1,(LI+::4,G_!;^NN'8AL44:$^@>Q^9M7 ''Z1FRAVK,U2:];
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M%I+.Y8PK6DSIM+&?3="V'H_FGN*$NW8/5+FQRZA;M(<@LDWZ='#<W%3WX6;
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MJ>^KUG%39<!0C<<,PRUAZ!=SZ1!S!1Y'A$7,,;622E6)A1V.0Z*I4JC-T'[
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M.TB(2./GFI%4$)>@";@D!S"43$J3<5I7<%35"*DAOZY*E5JQ1.H3'.=IH')
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MUYDJY0%BIR&T4*S]ULIRPFN2<H$;7F?NM=+@O/HS"V(F2<B%9"FYT,[C\)I
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ME"0_*)V1H/.YZ>.%,33W5*]_$Y60=WQ,94S>IU1G-&*%6WB&W,M(:9A>='^
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M!FA?)_IK=JC9X54T"FMVV"M[K++#UL[U!DEL[Y9OS17 +Q,>(P50HZ0#0VJ
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M.O T-ZQ6%:GL[G'NL;?4]J^]<R_@N_XO4$L#!!0    ( #2#7$X0)6,7N@@
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ME"6@# PI7* #8V"#F&L(;*"9A.Z@": @F68\SH@I\6/9?\HTJX3@!')N!$1
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M%]6XX#2!CH8M// :F*]R_= 8$!OPK^E3/\8TB2ES, "LA9M&%?/47DT-?GD
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MZD*BER<,=MBOZOAWO[FWT%W\#U!+ P04    "  T@UQ.S4]"$\H'   F10
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M36*/<>BCC/)0COQPX%B6,1BQ*,'Q2GTS!T<(B)\Q'B'3:/V"YHRK658$<T1
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M2P$"% ,4    "  T@UQ.^K_&54!N! !L0#P $0              @ $
M;&=N9"TR,#$X,3(S,2YH=&U02P$"% ,4    "  T@UQ.B\09M=P9  "J'0$
M$0              @ %O;@0 ;&=N9"TR,#$X,3(S,2YX<V102P$"% ,4
M"  T@UQ.8=>('I@U  #F00( %0              @ %ZB 0 ;&=N9"TR,#$X
M,3(S,5]C86PN>&UL4$L! A0#%     @ -(-<3C#F0KI-M   ^X8' !4
M         ( !1;X$ &QG;F0M,C Q.#$R,S%?9&5F+GAM;%!+ 0(4 Q0    (
M #2#7$Z\,5WK*'P! ,_-#P 5              "  <5R!0!L9VYD+3(P,3@Q
M,C,Q7VQA8BYX;6Q02P$"% ,4    "  T@UQ.Z"XH[:C?  #7+0H %0
M        @ $@[P8 ;&=N9"TR,#$X,3(S,5]P<F4N>&UL4$L! A0#%     @
M-(-<3OQF=O>ID   DDL% !H              ( !^\X' &QG;F0Q,C,Q,3AE
M>&AI8FET,3 T."TN:'1M4$L! A0#%     @ -(-<3LQ8 AGZ!   ?EP  !H
M             ( !W%\( &QG;F0Q,C,Q,3AE>&AI8FET,C$Q+6XN:'1M4$L!
M A0#%     @ -(-<3F,2-XS$ P  ^A8  !H              ( !#F4( &QG
M;F0Q,C,Q,3AE>&AI8FET,C,Q+6XN:'1M4$L! A0#%     @ -(-<3OT5@V?%
M"   VT\  !H              ( !"FD( &QG;F0Q,C,Q,3AE>&AI8FET,S$Q
M+6XN:'1M4$L! A0#%     @ -(-<3A E8Q>Z"   X$X  !H
M ( !!W(( &QG;F0Q,C,Q,3AE>&AI8FET,S$R+6XN:'1M4$L! A0#%     @
M-(-<3LU/0A/*!P  )D4  !H              ( !^7H( &QG;F0Q,C,Q,3AE
E>&AI8FET,S(Q+6XN:'1M4$L%!@     ,  P .@,  /N""     $!

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
